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Aliases for MEX3D Gene

Aliases for MEX3D Gene

  • Mex-3 RNA Binding Family Member D 2 3 5
  • RING Finger And KH Domain-Containing Protein 1 3 4
  • Ring Finger And KH Domain Containing 1 2 3
  • Bcl-2 ARE RNA Binding Protein 2 3
  • RING Finger Protein 193 3 4
  • RNF193 3 4
  • RKHD1 3 4
  • TINO 3 4
  • Ring Finger (C3HC4 Type) And KH Domain Containing 1 3
  • Mex-3 Homolog D (C. Elegans) 2
  • RNA-Binding Protein MEX3D 3
  • OK/SW-Cl.4 3
  • KIAA2031 4
  • MEX-3D 3
  • MEX3 3

External Ids for MEX3D Gene

Previous HGNC Symbols for MEX3D Gene

  • RKHD1

Previous GeneCards Identifiers for MEX3D Gene

  • GC19M001508
  • GC19M001328

Summaries for MEX3D Gene

GeneCards Summary for MEX3D Gene

MEX3D (Mex-3 RNA Binding Family Member D) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is MEX3B.

UniProtKB/Swiss-Prot for MEX3D Gene

  • RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.

Gene Wiki entry for MEX3D Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEX3D Gene

Genomics for MEX3D Gene

Regulatory Elements for MEX3D Gene

Enhancers for MEX3D Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F001568 0.8 ENCODE 0.8 -0.4 -389 0.2 ELF3 HDAC1 CBX3 CREB3L1 ARID4B ZNF48 ZEB1 ZNF335 CREM SP3 CIRBP ENSG00000261526 GC19M001562 MEX3D
GH19F001565 0.2 ENCODE 0.8 +1.1 1090 2.7 ELF3 CREB3L1 SREBF2 ARID4B SIN3A ZNF48 CREM HMG20B MXD4 REST GC19P001563 MEX3D
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MEX3D on UCSC Golden Path with GeneCards custom track

Promoters for MEX3D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001417294 558 2601 CREB3L1 ARID4B SIN3A ZNF48 GLIS2 SP3 MXD4 REST PPARG ZNF592

Genomic Location for MEX3D Gene

Chromosome:
19
Start:
1,554,669 bp from pter
End:
1,568,058 bp from pter
Size:
13,390 bases
Orientation:
Minus strand

Genomic View for MEX3D Gene

Genes around MEX3D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEX3D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEX3D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEX3D Gene

Proteins for MEX3D Gene

  • Protein details for MEX3D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XN8-MEX3D_HUMAN
    Recommended name:
    RNA-binding protein MEX3D
    Protein Accession:
    Q86XN8
    Secondary Accessions:
    • A0PJL8
    • A1L023
    • E9PAL6
    • Q71M49

    Protein attributes for MEX3D Gene

    Size:
    651 amino acids
    Molecular mass:
    64883 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ04763.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MEX3D Gene

    Alternative splice isoforms for MEX3D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEX3D Gene

Post-translational modifications for MEX3D Gene

Other Protein References for MEX3D Gene

Antibody Products

No data available for DME Specific Peptides for MEX3D Gene

Domains & Families for MEX3D Gene

Gene Families for MEX3D Gene

Protein Domains for MEX3D Gene

Graphical View of Domain Structure for InterPro Entry

Q86XN8

UniProtKB/Swiss-Prot:

MEX3D_HUMAN :
  • Binds RNA through its KH domains.
  • Contains 1 RING-type zinc finger.
Domain:
  • Binds RNA through its KH domains.
  • Contains 2 KH domains.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with MEX3D: view

Function for MEX3D Gene

Molecular function for MEX3D Gene

UniProtKB/Swiss-Prot Function:
RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.

Gene Ontology (GO) - Molecular Function for MEX3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0017091 AU-rich element binding IDA 14769789
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MEX3D: view
genes like me logo Genes that share phenotypes with MEX3D: view

Animal Model Products

miRNA for MEX3D Gene

miRTarBase miRNAs that target MEX3D

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MEX3D Gene

Localization for MEX3D Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEX3D Gene

Cytoplasm. Nucleus. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MEX3D Gene COMPARTMENTS Subcellular localization image for MEX3D gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MEX3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 14769789
GO:0005737 cytoplasm IEA --
GO:0048471 perinuclear region of cytoplasm IDA 14769789
genes like me logo Genes that share ontologies with MEX3D: view

Pathways & Interactions for MEX3D Gene

SuperPathways for MEX3D Gene

No Data Available

Interacting Proteins for MEX3D Gene

Gene Ontology (GO) - Biological Process for MEX3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010609 mRNA localization resulting in posttranscriptional regulation of gene expression NAS 14769789
GO:0061157 mRNA destabilization NAS 14769789
genes like me logo Genes that share ontologies with MEX3D: view

No data available for Pathways by source and SIGNOR curated interactions for MEX3D Gene

Transcripts for MEX3D Gene

Unigene Clusters for MEX3D Gene

Mex-3 homolog D (C. elegans):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEX3D Gene

No ASD Table

Relevant External Links for MEX3D Gene

GeneLoc Exon Structure for
MEX3D
ECgene alternative splicing isoforms for
MEX3D

Expression for MEX3D Gene

mRNA expression in normal human tissues for MEX3D Gene

mRNA differential expression in normal tissues according to GTEx for MEX3D Gene

This gene is overexpressed in Testis (x9.7).

Protein differential expression in normal tissues from HIPED for MEX3D Gene

This gene is overexpressed in Fetal Brain (30.8), Testis (18.8), Placenta (11.6), and Fetal ovary (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MEX3D Gene



Protein tissue co-expression partners for MEX3D Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MEX3D Gene:

MEX3D

SOURCE GeneReport for Unigene cluster for MEX3D Gene:

Hs.436495

mRNA Expression by UniProt/SwissProt for MEX3D Gene:

Q86XN8-MEX3D_HUMAN
Tissue specificity: Ubiquitously expressed in all the cell lines and tissues tested.
genes like me logo Genes that share expression patterns with MEX3D: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MEX3D Gene

Orthologs for MEX3D Gene

This gene was present in the common ancestor of animals.

Orthologs for MEX3D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEX3D 34 35
  • 98.78 (n)
dog
(Canis familiaris)
Mammalia MEX3D 34 35
  • 85.87 (n)
cow
(Bos Taurus)
Mammalia ADAMTSL5 34
  • 82.32 (n)
mouse
(Mus musculus)
Mammalia Mex3d 34 16 35
  • 80.25 (n)
rat
(Rattus norvegicus)
Mammalia Mex3d 34
  • 80.25 (n)
oppossum
(Monodelphis domestica)
Mammalia MEX3D 35
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MEX3D 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves MEX3D 34 35
  • 74.94 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia mex3d 34
  • 60.28 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100534722 34
  • 61.88 (n)
MEX3D 35
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11360 35
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mex-3 35
  • 33 (a)
OneToMany
Species where no ortholog for MEX3D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MEX3D Gene

ENSEMBL:
Gene Tree for MEX3D (if available)
TreeFam:
Gene Tree for MEX3D (if available)

Paralogs for MEX3D Gene

Paralogs for MEX3D Gene

(4) SIMAP similar genes for MEX3D Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MEX3D: view

Variants for MEX3D Gene

Sequence variations from dbSNP and Humsavar for MEX3D Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10407104 -- 1,562,644(+) agtga(A/G)ctaca intron-variant, upstream-variant-2KB
rs10420421 -- 1,560,833(+) GCTGG(C/T)CCCCA intron-variant
rs1054734 -- 1,555,535(+) GCAGA(A/T)GGCCC intron-variant, utr-variant-3-prime
rs111354402 -- 1,563,574(+) GTGCC(C/T)GGCAA intron-variant, upstream-variant-2KB
rs111425713 -- 1,564,029(+) GTCTC(A/G)ATTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MEX3D Gene

Variant ID Type Subtype PubMed ID
dgv6202n54 CNV gain+loss 21841781
dgv6203n54 CNV gain 21841781
dgv6204n54 CNV gain 21841781
esv23826 CNV loss 19812545
esv32942 CNV gain+loss 17666407
nsv1072837 CNV deletion 25765185
nsv1121962 CNV deletion 24896259
nsv1133435 CNV deletion 24896259
nsv1144853 CNV deletion 24896259
nsv517758 CNV loss 19592680
nsv578298 CNV loss 21841781
nsv578299 CNV gain 21841781
nsv578300 CNV loss 21841781
nsv578306 CNV loss 21841781
nsv578311 CNV gain 21841781
nsv578312 CNV loss 21841781
nsv953942 CNV deletion 24416366

Variation tolerance for MEX3D Gene

Gene Damage Index Score: 2.08; 38.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MEX3D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEX3D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEX3D Gene

Disorders for MEX3D Gene

Relevant External Links for MEX3D

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MEX3D

No disorders were found for MEX3D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEX3D Gene

Publications for MEX3D Gene

  1. Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. (PMID: 17267406) Buchet-Poyau K. … Billaud M. (Nucleic Acids Res. 2007) 2 3 4 64
  2. Identification of TINO: a new evolutionarily conserved BCL-2 AU-rich element RNA-binding protein. (PMID: 14769789) Donnini M. … Schiavone N. (J. Biol. Chem. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3 64
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64

Products for MEX3D Gene

Sources for MEX3D Gene

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