MEX3D Gene
protein-coding GIFtS: 47
GCID: GC19M001554
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mex-3 homolog D (C. elegans)(Previous name: ring finger and KH domain containing 1 )
(Previous symbol: RKHD1)
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Aliases
for MEX3D gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mex-3 Homolog D (C. Elegans)1 2 | | RING Finger Protein 1932 3 | | RKHD11 2 3 5 | | Tino1 | | RNF1931 2 3 | | MEX-3D2 | | KIAA20311 3 5 | | MEX32 | | TINO2 3 5 | | Bcl-2 ARE RNA Binding Protein2 | | OK/SW-Cl.41 | | Ring Finger (C3HC4 Type) And KH Domain Containing 12 | | Ring Finger And KH Domain Containing 11 2 | | RNA-Binding Protein MEX3D2 | | RING Finger And KH Domain-Containing Protein 12 3 | | |
Export aliases for MEX3D gene to outside databasesPrevious GC identifers: GC19M001508 GC19M001328 |
Summaries
for MEX3D gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MEX3D_HUMAN, Q86XN8Function: RNA binding protein, may be involved in post-transcriptional regulatory mechanisms (By similarity)
Gene Wiki entry for MEX3D
|
Genomic Views
for MEX3D gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MEX3D gene promoter:
c-Fos RP58 AP-1 p53 MyoD c-Jun NRSF form 2 ATF6 En-1 Egr-4
Other transcription factors
Search SABiosciences Chromatin IP Primers for MEX3D
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEX3D |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3MEX3D Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M001554: view genomic region
(about GC identifiers)
Start:
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1,554,668 bp from pter |
End:
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1,568,057 bp from pter |
Size:
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13,390 bases |
Orientation:
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minus strand |
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Proteins
for MEX3D gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MEX3D_HUMAN, Q86XN8 (See
protein sequence)Recommended Name: RNA-binding protein MEX3D Size: 651 amino acids; 64883 Da
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Note=Predominantly expressed in the cytoplasmand shuttles between the cytoplasm and the nucleus through the CRM1 export pathway (By similarity)
Sequence caution: Sequence=AAQ04763.1; Type=Erroneous initiation;
1 PDB 3D structure from  and Proteopedia  for MEX3D:2DGR (3D)
Secondary accessions: A0PJL8 A1L023 Q71M49Alternative splicing: 2 isoforms: Q86XN8-1 Q86XN8-2 Explore the universe of human proteins at neXtProt for MEX3D: NX_Q86XN8
Post-translational modifications:
Phosphorylated (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86XN8
MEX3D Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001167589.1 NP_976049.3
ENSEMBL proteins: ENSP00000384398 ENSP00000373476
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
MEX3D for ontologies About GeneDecksing
MEX3D Antibody Products:
Assay Products for MEX3D: |
Protein
Domains /
Families
for MEX3D gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MEX3D for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86XN8ProtoNet protein and cluster: Q86XN8 1 Blocks protein family: IPB001841 Zn-finger
UniProtKB/Swiss-Prot: MEX3D_HUMAN, Q86XN8Domain: Binds RNA through its KH domains (By similarity)Similarity: Contains 2 KH domainsSimilarity: Contains 1 RING-type zinc finger |
Function
for MEX3D gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MEX3D_HUMAN, Q86XN8Function: RNA binding protein, may be involved in post-transcriptional regulatory mechanisms (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEX3D (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEX3D (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): MEX3D (NM_203304) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MEX3D | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MEX3D |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEX3D |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
MEX3D for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for MEX3D:
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Pathways & Interactions
for MEX3D gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MEX3D
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5 Interacting proteins for MEX3D (Q86XN83 ENSP000003843984) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
MEX3D for ontologies About GeneDecksing
|
Drugs & Compounds
for MEX3D gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MEX3D
Search CenterWatch for drugs/clinical trials and news about MEX3D
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Transcripts
for MEX3D gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MEX3D gene (2 alternative transcripts): NM_001174118.1 NM_203304.3 Unigene Cluster for MEX3D: Mex-3 homolog D (C. elegans) Hs.436495 [show with all ESTs]Unigene Representative Sequence: NM_2033042 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000402693(uc010dsn.3) ENST00000388824(uc021uml.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEX3D (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEX3D (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): MEX3D (NM_203304) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MEX3D | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MEX3D |
Additional cDNA sequence: AB062435.1 AB107353.1 AF458084.1 AY950680.1 BC113384.1 BC113741.1 DQ225272.1 DQ225273.1 3 DOTS entries: DT.448151 DT.99955540 DT.75103215 24/84 AceView cDNA sequences (see all 84): BM741563 AI220266 BF057375 AW449796 CK904458 AI360101 AW663970 AW452132 AW293848 AB107353 BF057619 AF458084 AI650529 BQ102327 BF058170 AI245905 CK822929 BF059255 AI831413 NM_203304 AI676049 CF529505 AI479950 BM023498
GeneLoc Exon Structure
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Expression
for MEX3D gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MEX3D expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACTGCGCCG
About this image
See MEX3D Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MEX3D
SOURCE GeneReport for Unigene cluster: Hs.436495
UniProtKB/Swiss-Prot: MEX3D_HUMAN, Q86XN8Tissue specificity: Ubiquitously expressed in all the cell lines and tissues tested
SABiosciences Expression via Pathway-Focused PCR Array including MEX3D:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MEX3D
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MEX3D | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEX3D | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEX3D | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEX3D |
Orthologs
for MEX3D gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for MEX3D gene from 5/16 species (see all 16) About this table
ENSEMBL Gene Tree for MEX3D (if available)
TreeFam Gene Tree for MEX3D (if available) |
Paralogs
for MEX3D gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MEX3D gene
- MEX3B2 MEX3A2 MEX3C2
4 SIMAP similar genes for MEX3D using alignment to 2 protein entries: MEX3D_HUMAN (see all proteins):RKHD1 MEX3B MEX3A MEX3C
MEX3D for paralogs About GeneDecksing
|
Genomic Variants
for MEX3D gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MEX3D (1554668 - 1568057 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for MEX3D
3 CNVs: 73275 50078 7191 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MEX3D |
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Disorders
/ Diseases
for MEX3D gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 MEX3D for disorders About MalaCards
MEX3D for disorders About GeneDecksing
OMIM gene information: 611009
OMIM disorders: --
Export disorders for MEX3D gene to outside databases
|
Publications
for MEX3D gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MEX3D gene integrated from 9 sources:
(articles sorted by number of sources associating them with MEX3D) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. (PubMed id 17267406)1, 2, 3 Buchet-Poyau K.... Billaud M. (2007)
- Identification of TINO: a new evolutionarily conserved BCL-2 AU-rich element RNA-binding protein. (PubMed id 14769789)1, 2 Donnini M.... Schiavone N. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Interaction with 14-3-3 adaptors regulates the sorting of hMex-3B RNA-binding protein to distinct classes of RNA granules. (PubMed id 18779327)1 Courchet J....Billaud M. (2008)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for MEX3D gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing MEX3D gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MEX3D gene
(According to HUGE)
About This Section
| |
Specialized Databases showing MEX3D gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MEX3D | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for MEX3D gene:
Search GeneIP for patents involving MEX3D
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MEX3D gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for MEX3D | | OriGene shRNA RFP for MEX3D | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MEX3D | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MEX3D | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MEX3D | | OriGene 3'-UTR Clone for MEX3D | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEX3D | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEX3D | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MEX3D | | OriGene Custom Protein Services for MEX3D | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MEX3D | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MEX3D | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEX3D | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEX3D | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEX3D | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEX3D |
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| | | | Search Tocris compounds for MEX3D |
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 | | | MEX3D Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEX3D |
|  |  |  | | | | ThermoFisher Antibodies for MEX3D |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MEX3D |
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