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Aliases for MEX3D Gene

Aliases for MEX3D Gene

  • Mex-3 RNA Binding Family Member D 2 3
  • RKHD1 3 4 6
  • TINO 3 4 6
  • RING Finger And KH Domain-Containing Protein 1 3 4
  • Ring Finger And KH Domain Containing 1 2 3
  • Bcl-2 ARE RNA Binding Protein 2 3
  • RING Finger Protein 193 3 4
  • KIAA2031 4 6
  • RNF193 3 4
  • Ring Finger (C3HC4 Type) And KH Domain Containing 1 3
  • Mex-3 Homolog D (C. Elegans) 2
  • RNA-Binding Protein MEX3D 3
  • OK/SW-Cl.4 3
  • MEX-3D 3
  • MEX3 3

External Ids for MEX3D Gene

Previous HGNC Symbols for MEX3D Gene

  • RKHD1

Previous GeneCards Identifiers for MEX3D Gene

  • GC19M001508
  • GC19M001328

Summaries for MEX3D Gene

GeneCards Summary for MEX3D Gene

MEX3D (Mex-3 RNA Binding Family Member D) is a Protein Coding gene. GO annotations related to this gene include AU-rich element binding. An important paralog of this gene is MEX3A.

UniProtKB/Swiss-Prot for MEX3D Gene

  • RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.

Gene Wiki entry for MEX3D Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEX3D Gene

Genomics for MEX3D Gene

Regulatory Elements for MEX3D Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MEX3D Gene

Start:
1,554,669 bp from pter
End:
1,568,058 bp from pter
Size:
13,390 bases
Orientation:
Minus strand

Genomic View for MEX3D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MEX3D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEX3D Gene

Proteins for MEX3D Gene

  • Protein details for MEX3D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XN8-MEX3D_HUMAN
    Recommended name:
    RNA-binding protein MEX3D
    Protein Accession:
    Q86XN8
    Secondary Accessions:
    • A0PJL8
    • A1L023
    • E9PAL6
    • Q71M49

    Protein attributes for MEX3D Gene

    Size:
    651 amino acids
    Molecular mass:
    64883 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ04763.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MEX3D Gene

    Alternative splice isoforms for MEX3D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEX3D Gene

Proteomics data for MEX3D Gene at MOPED

Post-translational modifications for MEX3D Gene

Other Protein References for MEX3D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MEX3D Gene

Domains for MEX3D Gene

Gene Families for MEX3D Gene

HGNC:
  • MEX3 :Mex-3 homologs
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for MEX3D Gene

Suggested Antigen Peptide Sequences for MEX3D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86XN8

UniProtKB/Swiss-Prot:

MEX3D_HUMAN :
  • Q86XN8
Domain:
  • Binds RNA through its KH domains.
  • Contains 2 KH domains.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with MEX3D: view

Function for MEX3D Gene

Molecular function for MEX3D Gene

UniProtKB/Swiss-Prot Function:
RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.

Gene Ontology (GO) - Molecular Function for MEX3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0017091 AU-rich element binding IDA 14769789
genes like me logo Genes that share ontologies with MEX3D: view

Phenotypes for MEX3D Gene

GenomeRNAi human phenotypes for MEX3D:
genes like me logo Genes that share phenotypes with MEX3D: view

Animal Model Products

miRNA for MEX3D Gene

miRTarBase miRNAs that target MEX3D

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MEX3D

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MEX3D Gene

Localization for MEX3D Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEX3D Gene

Cytoplasm. Nucleus. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MEX3D Gene COMPARTMENTS Subcellular localization image for MEX3D gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MEX3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 14769789
GO:0048471 perinuclear region of cytoplasm IDA 14769789
genes like me logo Genes that share ontologies with MEX3D: view

Pathways for MEX3D Gene

SuperPathways for MEX3D Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for MEX3D Gene

Selected Interacting proteins: Q86XN8-MEX3D_HUMAN for MEX3D Gene via I2D

Symbol External ID(s) Details
BCL2L11

Gene Ontology (GO) - Biological Process for MEX3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010609 mRNA localization resulting in posttranscriptional regulation of gene expression NAS 14769789
GO:0061157 mRNA destabilization NAS 14769789
genes like me logo Genes that share ontologies with MEX3D: view

No data available for Pathways by source for MEX3D Gene

Transcripts for MEX3D Gene

Unigene Clusters for MEX3D Gene

Mex-3 homolog D (C. elegans):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MEX3D

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEX3D Gene

No ASD Table

Relevant External Links for MEX3D Gene

GeneLoc Exon Structure for
MEX3D
ECgene alternative splicing isoforms for
MEX3D

Expression for MEX3D Gene

mRNA expression in normal human tissues for MEX3D Gene

mRNA differential expression in normal tissues according to GTEx for MEX3D Gene

This gene is overexpressed in Testis (9.7).

Protein differential expression in normal tissues for MEX3D Gene

This gene is overexpressed in Fetal Brain (30.8), Testis (18.8), Placenta (11.6), and Fetal ovary (7.8).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for MEX3D Gene

SOURCE GeneReport for Unigene cluster for MEX3D Gene Hs.436495

mRNA Expression by UniProt/SwissProt for MEX3D Gene

Q86XN8-MEX3D_HUMAN
Tissue specificity: Ubiquitously expressed in all the cell lines and tissues tested.
genes like me logo Genes that share expressions with MEX3D: view

Expression partners for MEX3D Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MEX3D Gene

Orthologs for MEX3D Gene

This gene was present in the common ancestor of animals.

Orthologs for MEX3D Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADAMTSL5 35
  • 82.32 (n)
  • 82.68 (a)
dog
(Canis familiaris)
Mammalia MEX3D 35
  • 85.87 (n)
  • 85.94 (a)
MEX3D 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mex3d 35
  • 80.25 (n)
  • 83.05 (a)
Mex3d 16
Mex3d 36
  • 55 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MEX3D 35
  • 98.78 (n)
  • 98.35 (a)
MEX3D 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mex3d 35
  • 80.25 (n)
  • 82.04 (a)
oppossum
(Monodelphis domestica)
Mammalia MEX3D 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MEX3D 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves MEX3D 35
  • 74.94 (n)
  • 72.26 (a)
MEX3D 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mex3d 35
  • 60.28 (n)
  • 67.44 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100534722 35
  • 61.88 (n)
  • 62.13 (a)
MEX3D 36
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11360 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mex-3 36
  • 33 (a)
OneToMany
Species with no ortholog for MEX3D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MEX3D Gene

ENSEMBL:
Gene Tree for MEX3D (if available)
TreeFam:
Gene Tree for MEX3D (if available)

Paralogs for MEX3D Gene

Paralogs for MEX3D Gene

Selected SIMAP similar genes for MEX3D Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MEX3D: view

Variants for MEX3D Gene

Sequence variations from dbSNP and Humsavar for MEX3D Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1054734 -- 1,555,535(+) GCAGA(A/T)GGCCC intron-variant, utr-variant-3-prime
rs2277752 -- 1,555,552(+) CGTGG(C/T)GGTCC intron-variant, utr-variant-3-prime
rs2277753 -- 1,555,743(+) GGGGC(C/T)GAGGA synonymous-codon, reference
rs3209155 -- 1,555,390(+) CACGC(C/G)TGAGG splice-acceptor-variant, utr-variant-3-prime
rs3209156 -- 1,555,392(+) CGCCT(A/G)AGGCG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MEX3D Gene

Variant ID Type Subtype PubMed ID
nsv910292 CNV Loss 21882294
dgv3583n71 CNV Loss 21882294
dgv3589n71 CNV Loss 21882294
esv32942 CNV Gain+Loss 17666407
nsv910499 CNV Loss 21882294
dgv3601n71 CNV Loss 21882294
dgv3602n71 CNV Loss 21882294
dgv3603n71 CNV Loss 21882294
dgv3607n71 CNV Loss 21882294
dgv3608n71 CNV Loss 21882294
dgv3609n71 CNV Loss 21882294
nsv910532 CNV Loss 21882294
nsv517758 CNV Loss 19592680
dgv3610n71 CNV Loss 21882294
nsv910540 CNV Loss 21882294
esv23826 CNV Loss 19812545

Relevant External Links for MEX3D Gene

HapMap Linkage Disequilibrium report
MEX3D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEX3D Gene

Disorders for MEX3D Gene

No disorders were found for MEX3D Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MEX3D Gene

Publications for MEX3D Gene

  1. Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. (PMID: 17267406) Buchet-Poyau K. … Billaud M. (Nucleic Acids Res. 2007) 2 3 4
  2. Identification of TINO: a new evolutionarily conserved BCL-2 AU-rich element RNA-binding protein. (PMID: 14769789) Donnini M. … Schiavone N. (J. Biol. Chem. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Interaction with 14-3-3 adaptors regulates the sorting of hMex-3B RNA-binding protein to distinct classes of RNA granules. (PMID: 18779327) Courchet J. … Billaud M. (J. Biol. Chem. 2008) 3

Products for MEX3D Gene

Sources for MEX3D Gene

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