Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MEX3C Gene

protein-coding   GIFtS: 45
GCID: GC18M048700

mex-3 homolog C (C. elegans)

(Previous name: ring finger and KH domain containing 2 )
(Previous symbol: RKHD2)
 Explore 1 disease affiliated with
MEX3C via our new
 Human Malady Compendium 
Biological research products
for MEX3C
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Mex-3 Homolog C (C. Elegans)1 2     FLJ388711
RKHD21 2 3 5     MEX-3C2
RNF1941 2 3     RNA-Binding E3 Ubiquitin-Protein Ligase MEX3C2
Ring Finger And KH Domain Containing 21 2     RNA-Binding Protein MEX3C2
RING Finger And KH Domain-Containing Protein 22 3     EC 6.3.2.-3
RING Finger Protein 1942 3     

External Ids:    HGNC: 280401   Entrez Gene: 513202   Ensembl: ENSG000001766247   OMIM: 6110055   UniProtKB: Q5U5Q33   

Export aliases for MEX3C gene to outside databases

Previous GC identifers: GC18M046955 GC18M045556


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MEX3C:
This gene encodes a member of a family of proteins with two K homology (KH) RNA-binding domains and a C-terminal
RING-finger domain. The protein interacts with mRNA via the KH domains, and the protein shuttles between the nucleus
and cytoplasm. Polymorphisms in this gene may contribute to hypertension. (provided by RefSeq, Oct 2009)

UniProtKB/Swiss-Prot: MEX3C_HUMAN, Q5U5Q3
Function: E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to
the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent
translation, but ubiquitin ligase activity is required for mRNA degradation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_010966.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MEX3C gene promoter:
         HFH-3   C/EBPbeta   AML1a   AP-4   Arnt   GATA-1   MEF-2A   FOXI1   ZIC2/Zic2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMEX3C promoter sequence
   Search SABiosciences Chromatin IP Primers for MEX3C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEX3C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.2   Ensembl cytogenetic band:  18q21.2   HGNC cytogenetic band: 18q21.1

MEX3C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEX3C gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M048700:  view genomic region     (about GC identifiers)

Start:
48,700,920 bp from pter      End:
48,744,674 bp from pter
Size:
43,755 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MEX3C_HUMAN, Q5U5Q3 (See protein sequence)
Recommended Name: RNA-binding E3 ubiquitin-protein ligase MEX3C  
Size: 659 amino acids; 69366 Da
Subunit: Interacts with USP7, which antagonizes the ability to degrade mRNA
Subcellular location: Cytoplasm. Nucleus. Note=Predominantly expressed in the cytoplasm and shuttles between the
cytoplasm and the nucleus through the CRM1 export pathway
Sequence caution: Sequence=AAF64269.1; Type=Erroneous termination; Positions=514; Note=Translated as Glu;
Sequence=AAF64269.1; Type=Frameshift; Positions=520, 525;
Secondary accessions: A1L022 Q9NZE3

Explore the universe of human proteins at neXtProt for MEX3C: NX_Q5U5Q3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5U5Q3

  • MEX3C Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_057710.3  
    ENSEMBL proteins: 
     ENSP00000385610   ENSP00000468078  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for MEX3C 
    GenScript Custom Purified and Recombinant Proteins Services for MEX3C
    Novus Biologicals MEX3C Proteins
    Novus Biologicals MEX3C Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MEX3C

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0043231intracellular membrane-bounded organelle IDA--


    MEX3C for ontologies           About GeneDecksing



    MEX3C Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: MEX3C
    OriGene Custom Antibody Services for MEX3C 
    GenScript Custom Superior Antibodies Services for MEX3C
    Novus Biologicals MEX3C Antibodies
    Search for Antibodies for MEX3C at Abcam  
    Uscn Antibodies for MEX3C
    ThermoFisher Antibodies for MEX3C

    Assay Products for MEX3C: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MEX3C
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MEX3C


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MEX3C for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001841 Znf_RING
     IPR004087 KH_dom
     IPR013083 Znf_RING/FYVE/PHD
     IPR004088 KH_dom_type_1

    Graphical View of Domain Structure for InterPro Entry Q5U5Q3

    ProtoNet protein and cluster: Q5U5Q3

    UniProtKB/Swiss-Prot: MEX3C_HUMAN, Q5U5Q3
    Domain: Binds RNA through its KH domains
    Similarity: Contains 2 KH domains
    Similarity: Contains 1 RING-type zinc finger


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: MEX3C_HUMAN, Q5U5Q3
    Function: E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to
    the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent
    translation, but ubiquitin ligase activity is required for mRNA degradation

    Enzyme Number (IUBMB): EC 6.3.2.-1

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: MEX3C
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MEX3C
    8/100 QIAGEN miScript miRNA Assays for microRNAs that regulate MEX3C (see all 100):
    hsa-miR-411* hsa-miR-361-5p hsa-miR-520f hsa-miR-374a hsa-miR-3074-3p hsa-miR-30d hsa-miR-30a hsa-miR-3122
    SwitchGear 3'UTR luciferase reporter plasmidMEX3C 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MEX3C (see all 7)
    OriGene shRNA RFP: MEX3C
    OriGene siRNA: MEX3C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEX3C

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MEX3C

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEX3C (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEX3C
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MEX3C (NM_016626)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEX3C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEX3C 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MEX3C
    Search LifeMap BioReagents cell lines for MEX3C

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEX3C

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--


    MEX3C for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for MEX3C:
     G0/1 arrest  Increased G1 DNA content  Increased cell number in S 

    Animal Models:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mex3c):
     growth/size  homeostasis/metabolism  limbs/digits/tail  mortality/aging  respiratory system 
     skeleton 

    MEX3C for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MEX3C

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/98 Interacting proteins for MEX3C (Q5U5Q32 ENSP000003856104) via UniProtKB, MINT, STRING, and/or I2D (see all 98)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP7Q930092MINT-8394717 MINT-8394378 MINT-8394813
    CADP277082MINT-8395092
    CC2D1AQ6P1N02MINT-8395092
    DDX17Q928412MINT-8395092
    DDX21Q9NR302MINT-8395092
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MEX3C
    Search CenterWatch for drugs/clinical trials and news about MEX3C 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MEX3C gene: 
    NM_016626.4  

    Unigene Cluster for MEX3C:

    Mex-3 homolog C (C. elegans)
    Hs.465144  [show with all ESTs]
    Unigene Representative Sequence: NM_016626
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000406189(uc002lfc.4) ENST00000591040 ENST00000592416

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: MEX3C
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MEX3C
    8/100 QIAGEN miScript miRNA Assays for microRNAs that regulate MEX3C (see all 100):
    hsa-miR-411* hsa-miR-361-5p hsa-miR-520f hsa-miR-374a hsa-miR-3074-3p hsa-miR-30d hsa-miR-30a hsa-miR-3122
    SwitchGear 3'UTR luciferase reporter plasmidMEX3C 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MEX3C (see all 7)
    OriGene shRNA RFP: MEX3C
    OriGene siRNA: MEX3C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEX3C
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEX3C (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEX3C
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MEX3C (NM_016626)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEX3C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEX3C 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MEX3C
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MEX3C
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEX3C
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEX3C

    Additional cDNA sequence: 

    AF208855.1 AK096190.1 AK312049.1 AL833519.1 AY950679.1 BC041122.1 BC063244.1 BC153820.1 

    7 DOTS entries:

    DT.413433  DT.95151340  DT.100775242  DT.40132580  DT.86852245  DT.95335602  DT.95151342 

    24/159 AceView cDNA sequences (see all 159):

    AA766791 BE886786 AI273165 AW770234 AI431793 AK096190 NM_016626 BX494147 
    BC063244 AA480855 AI370197 BU181911 BI520251 BF224335 AA629749 AA455774 
    BC032952 AI282549 H27359 BF056919 BU903030 AI400580 AA889208 BX279940 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MEX3C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See MEX3C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MEX3C

    SOURCE GeneReport for Unigene cluster: Hs.465144

    UniProtKB/Swiss-Prot: MEX3C_HUMAN, Q5U5Q3
    Tissue specificity: Highest levels found in fetal brain and testis. Also expressed in thymus, salivary gland and
    uterus. Highly expressed in cells of the innate immune system, in particular activated NK cells. Week expression in
    the intestine

        SABiosciences Expression via Pathway-Focused PCR Array including MEX3C: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MEX3C
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MEX3C
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEX3C
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEX3C
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEX3C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MEX3C gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia MEX3C6
    --
    94(a)
    1 ↔ 1
    GL343471.1(532613-533845)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU152769.12   -- 93.56(n)    BU152769.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01041961.16
    --
    60(a)
    1 ↔ 1
    5(7176108-7180791)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG113606
    --
    31(a)
    possible ortholog
    4(691768-711276)
    worm
    (Caenorhabditis elegans)
    Secernentea mex-36
    Muscle EXcess family member (mex-3)
    36(a)
    possible ortholog
    I(127297-134065)


    ENSEMBL Gene Tree for MEX3C (if available)
    TreeFam Gene Tree for MEX3C (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MEX3C gene
    MEX3B2  MEX3A2  MEX3D2  
    4 SIMAP similar genes for MEX3C using alignment to 2 protein entries:     MEX3C_HUMAN (see all proteins):
    RKHD1    MEX3B    MEX3A    MEX3D

    MEX3C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/415 NCBI SNPs in MEX3C are shown (see all 415    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1161712441,2
    F,--48700451(+) TTTTCA/GGAAGG 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs10801691,2
    C,H--48700452(-) ACCTTC/TTGAAA 1 -- ds50018Minor allele frequency- T:0.00NA EA NS 586
    rs2014251211,2
    --48700777(+) AAGAG-/CACACAC 1 -- ds50010--------
    rs1812669251,2
    --48700782(+) GCACAC/TACACA 1 -- ds50010--------
    rs1502449501,2
    --48700849(+) AAGAAA/CATTTT 1 -- ds50010--------
    rs1389142231,2
    --48700856(+) TTTTCA/GATTCT 1 -- ds50010--------
    rs115393021,2
    C,H--48701125(+) CAAAAG/TAGTGT 1 -- ut312Minor allele frequency- T:0.00NS NA 282
    rs1850217261,2
    --48701192(+) TTTTAG/TAAACA 1 -- ut310--------
    rs772371231,2
    F,--48701225(+) GATTCC/GTTGGC 1 -- ut311Minor allele frequency- G:0.06WA 118
    rs1894856991,2
    --48701495(+) TACTAC/TTGAAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MEX3C (48700920 - 48744674 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MEX3C: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MEX3C
    DNA2.0 Custom Variant and Variant Library Synthesis for MEX3C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MEX3C for disorders           About GeneDecksing

    OMIM gene information: 611005    OMIM disorders: --

    UniProtKB/Swiss-Prot: MEX3C_HUMAN, Q5U5Q3
  • Note=Genetic variations in MEX3C may be associated with susceptibility to essential hypertension

  • 1 disease for MEX3C:    About MalaCards
    hypertension

    Human Genome Epidemiology (HuGE) Navigator: MEX3C (1 document)

    Export disorders for MEX3C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MEX3C gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with MEX3C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. (PubMed id 17267406)1, 2, 3 Buchet-Poyau K.... Billaud M. (2007)
    2. The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation. (PubMed id 22863774)1, 2 Cano F....Lehner P.J. (2012)
    3. Implication of chromosome 18 in hypertension by sibling pair and association analyses: putative involvement of the RKHD2 gene. (PubMed id 17015768)1, 2 Guzman B....Poch E. (2006)
    4. DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)1, 2 Nusbaum C.... Lander E.S. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. A genome-wide association study of host genetic determ inants of the antibody response to Anthrax Vaccine Adsorbed. (PubMed id 22658931)1 Pajewski N.M....Kaslow R.A. (2012)
    7. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PubMed id 22610502)1 Kennedy R.B....Poland G.A. (2012)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51320 HGNC: 28040 AceView: RKHD2 Ensembl:ENSG00000176624 euGenes: HUgn51320
    ECgene: MEX3C H-InvDB: MEX3C

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MEX3C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MEX3C gene:
    Search GeneIP for patents involving MEX3C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for MEX3C   OriGene shRNA RFP for MEX3C  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MEX3C   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MEX3C  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for MEX3C   OriGene 3'-UTR Clone for MEX3C  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEX3C   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEX3C  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MEX3C   OriGene Custom Protein Services for MEX3C  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MEX3C
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MEX3C
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEX3C
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEX3C
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEX3C
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEX3C
     GenScript Custom Purified and Recombinant Proteins Services for MEX3C GenScript cDNA clones with any tag delivered in your preferred vector for MEX3C
     GenScript Custom Assay Services for MEX3C GenScript Custom Superior Antibodies Services for MEX3C
     GenScript Custom overexpressing Cell Line Services for MEX3C CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MEX3C promoter
     Search Chromatin IP Primers for MEX3C
     RT2 qPCR Primer Assay in human, mouse, rat MEX3C
     Search GNC Networks for MEX3C
     SABiosciences PCR Arrays including human, mouse, rat MEX3C
     Search Tocris compounds for MEX3C
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MEX3C antibodies
     MEX3C proteins
     MEX3C lysates
     Search for Antibodies for MEX3C at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for MEX3C
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     MEX3C Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for MEX3C
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEX3C
     SwitchGear 3'UTR luciferase reporter plasmids for MEX3C
     SwitchGear Promoter luciferase reporter plasmids for MEX3C
     ThermoFisher Antibodies for MEX3C
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEX3C
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MEX3C gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4