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MEX3C Gene

protein-coding   GIFtS: 49
GCID: GC18M048700

Mex-3 RNA Binding Family Member C

(Previous names: ring finger and KH domain containing 2, mex-3 homolog C...)
(Previous symbol: RKHD2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mex-3 RNA Binding Family Member C1 2     Mex-3 Homolog C (C. Elegans)1
RKHD21 2 3 5     MEX-3C2
Ring Finger And KH Domain Containing 21 2     RNA-Binding E3 Ubiquitin-Protein Ligase MEX3C2
RNF1942 3     RNA-Binding Protein MEX3C2
RING Finger And KH Domain-Containing Protein 22 3     EC 6.3.2.-3
RING Finger Protein 1942 3     

External Ids:    HGNC: 280401   Entrez Gene: 513202   Ensembl: ENSG000001766247   OMIM: 6110055   UniProtKB: Q5U5Q33   

Export aliases for MEX3C gene to outside databases

Previous GC identifers: GC18M046955 GC18M045556


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MEX3C Gene:
This gene encodes a member of a family of proteins with two K homology (KH) RNA-binding domains and a C-terminal
RING-finger domain. The protein interacts with mRNA via the KH domains, and the protein shuttles between the
nucleus and cytoplasm. Polymorphisms in this gene may contribute to hypertension. (provided by RefSeq, Oct 2009)

GeneCards Summary for MEX3C Gene:
MEX3C (mex-3 RNA binding family member C) is a protein-coding gene. Diseases associated with MEX3C include hypertension, and smallpox. GO annotations related to this gene include RNA binding and ligase activity. An important paralog of this gene is MEX3B.

UniProtKB/Swiss-Prot: MEX3C_HUMAN, Q5U5Q3
Function: E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds
to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to
prevent translation, but ubiquitin ligase activity is required for mRNA degradation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000018.10  NC_018929.2  NT_010966.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the MEX3C gene promoter:
         HFH-3   C/EBPbeta   AML1a   AP-4   Arnt   GATA-1   MEF-2A   FOXI1   ZIC2/Zic2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMEX3C promoter sequence
   Search Chromatin IP Primers for MEX3C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MEX3C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.2   Ensembl cytogenetic band:  18q21.2   HGNC cytogenetic band: 18q21.1

MEX3C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEX3C gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M048700:  view genomic region     (about GC identifiers)

Start:
48,700,920 bp from pter      End:
48,744,674 bp from pter
Size:
43,755 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MEX3C_HUMAN, Q5U5Q3 (See protein sequence)
Recommended Name: RNA-binding E3 ubiquitin-protein ligase MEX3C  
Size: 659 amino acids; 69366 Da
Subunit: Interacts with USP7, which antagonizes the ability to degrade mRNA
Sequence caution: Sequence=AAF64269.1; Type=Erroneous termination; Positions=514; Note=Translated as Glu;
Sequence=AAF64269.1; Type=Frameshift; Positions=520, 525;
Secondary accessions: A1L022 Q9NZE3

Explore the universe of human proteins at neXtProt for MEX3C: NX_Q5U5Q3

Explore proteomics data for MEX3C at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys309
  • Modification sites at PhosphoSitePlus

  • See MEX3C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057710.3  
    ENSEMBL proteins: 
     ENSP00000385610   ENSP00000468078  

    MEX3C Human Recombinant Protein Products:

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    Novus Biologicals MEX3C Proteins
    Novus Biologicals MEX3C Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    MEX3C Antibody Products:

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    MEX3C Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MEX3: Mex-3 homologs
    RNF: RING-type (C3HC4) zinc fingers

    4 InterPro protein domains:
     IPR001841 Znf_RING
     IPR004087 KH_dom
     IPR013083 Znf_RING/FYVE/PHD
     IPR004088 KH_dom_type_1

    Graphical View of Domain Structure for InterPro Entry Q5U5Q3

    ProtoNet protein and cluster: Q5U5Q3

    UniProtKB/Swiss-Prot: MEX3C_HUMAN, Q5U5Q3
    Domain: Binds RNA through its KH domains
    Similarity: Contains 2 KH domains
    Similarity: Contains 1 RING-type zinc finger


    MEX3C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MEX3C_HUMAN, Q5U5Q3
    Function: E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds
    to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to
    prevent translation, but ubiquitin ligase activity is required for mRNA degradation

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    MEX3C for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for MEX3C:
     G0/1 arrest  Increased G1 DNA content  Increased cell number in S 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mex3c):
     growth/size/body  homeostasis/metabolism  limbs/digits/tail  mortality/aging  respiratory system 
     skeleton 

    MEX3C for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MEX3C
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MEX3C

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MEX3C
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MEX3C

    miRNA
    Products:
        
    miRTarBase miRNAs that target MEX3C:
    hsa-mir-744-5p (MIRT037656), hsa-mir-103a-3p (MIRT026985), hsa-mir-374b-5p (MIRT016060)

    Block miRNA regulation of human, mouse, rat MEX3C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MEX3C (see all 100):
    hsa-miR-411* hsa-miR-361-5p hsa-miR-520f hsa-miR-374a hsa-miR-3074-3p hsa-miR-30d hsa-miR-30a hsa-miR-3122
    SwitchGear 3'UTR luciferase reporter plasmidMEX3C 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MEX3C
    Predesigned siRNA for gene silencing in human, mouse, rat MEX3C

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for MEX3C

    Clone
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    OriGene clones in human, mouse for MEX3C (see all 7)
    OriGene ORF clones in mouse, rat for MEX3C
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MEX3C (NM_016626)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEX3C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEX3C

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MEX3C 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEX3C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MEX3C_HUMAN, Q5U5Q3: Cytoplasm. Nucleus. Note=Predominantly expressed in the cytoplasm and shuttles between the
    cytoplasm and the nucleus through the CRM1 export pathway. May act as suppressor of replication stress and
    chromosome missegregation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    plasma membrane2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0043231intracellular membrane-bounded organelle ----

    MEX3C for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including MEX3C: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MEX3C

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for MEX3C (Q5U5Q31, 2 ENSP000003856104) via UniProtKB, MINT, STRING, and/or I2D (see all 103)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP7Q930091, 2EBI-2864451,EBI-302474 MINT-8394717 MINT-8394378 MINT-8394813
    CADP277082MINT-8395092
    CC2D1AQ6P1N02MINT-8395092
    DDX17Q928412MINT-8395092
    DDX21Q9NR302MINT-8395092
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003415chondrocyte hypertrophy IEA--
    GO:0045598regulation of fat cell differentiation IEA--
    GO:0097009energy homeostasis IEA--

    MEX3C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MEX3C



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MEX3C gene: 
    NM_016626.4  

    Unigene Cluster for MEX3C:

    Mex-3 homolog C (C. elegans)
    Hs.465144  [show with all ESTs]
    Unigene Representative Sequence: NM_016626
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000406189(uc002lfc.4) ENST00000591040 ENST00000592416
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MEX3C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MEX3C (see all 100):
    hsa-miR-411* hsa-miR-361-5p hsa-miR-520f hsa-miR-374a hsa-miR-3074-3p hsa-miR-30d hsa-miR-30a hsa-miR-3122
    SwitchGear 3'UTR luciferase reporter plasmidMEX3C 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MEX3C
    Predesigned siRNA for gene silencing in human, mouse, rat MEX3C
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MEX3C (NM_016626)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEX3C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEX3C
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MEX3C
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MEX3C
      QuantiTect SYBR Green Assays in human, mouse, rat MEX3C
      QuantiFast Probe-based Assays in human, mouse, rat MEX3C

    Additional mRNA sequence: 

    AF208855.1 AK096190.1 AK312049.1 AL833519.1 AY950679.1 BC041122.1 BC063244.1 BC153820.1 

    7 DOTS entries:

    DT.413433  DT.95151340  DT.100775242  DT.40132580  DT.86852245  DT.95335602  DT.95151342 

    Selected AceView cDNA sequences (see all 159):

    BC063244 AI282549 AA766791 AA889208 AI370197 BM800874 CA310954 BF224335 
    BC032952 T16760 AI885521 BF056919 AA582259 AA491040 BX279940 AI273165 
    AW770234 AI147995 BC041122 BM667586 AA455774 BE886786 BX494147 BM710775 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MEX3C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MEX3C Expression
    About this image

    MEX3C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MEX3C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.465144

    UniProtKB/Swiss-Prot: MEX3C_HUMAN, Q5U5Q3
    Tissue specificity: Highest levels found in fetal brain and testis. Also expressed in thymus, salivary gland and
    uterus. Highly expressed in cells of the innate immune system, in particular activated NK cells. Week expression
    in the intestine

        Pathway & Disease-focused RT2 Profiler PCR Array including MEX3C: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MEX3C
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MEX3C
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEX3C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MEX3C gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mex3c1 , 5 mex3 homolog C (C. elegans)1, 5 92.22(n)1
    95.79(a)1
      18 (49.29 cM)5
    2403961  NM_001039214.41  NP_001034303.31 
     735730445 
    lizard
    (Anolis carolinensis)
    Reptilia MEX3C6
    mex-3 RNA binding family member C
    92(a)
    1 ↔ 1
    GL343471.1(530251-539270)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU152769.12   -- 93.56(n)    BU152769.1 
    zebrafish
    (Danio rerio)
    Actinopterygii MEX3C6
    mex-3 RNA binding family member C
    60(a)
    1 ↔ 1
    5(7176108-7180791) ENSDARG00000068971
    fruit fly
    (Drosophila melanogaster)
    Insecta CG113606
    --
    32(a)
    1 → many
    4(691768-711276)
    worm
    (Caenorhabditis elegans)
    Secernentea mex-36
    Protein MEX-3, isoform b
    37(a)
    1 → many
    I(127297-134065) WBGene00003229


    ENSEMBL Gene Tree for MEX3C (if available)
    TreeFam Gene Tree for MEX3C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MEX3C gene
    MEX3B2  MEX3A2  MEX3D2  
    4 SIMAP similar genes for MEX3C using alignment to 2 protein entries:     MEX3C_HUMAN (see all proteins):
    RKHD1    MEX3B    MEX3A    MEX3D

    MEX3C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MEX3C (see all 514)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1161712441,2
    F--48700558(+) TTTTCA/GGAAGG 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs10801691,2
    C,H--48700559(-) ACCTTC/TTGAAA 1 -- ds50018Minor allele frequency- T:0.00NA EA NS 586
    rs2014251211,2
    C--48700884(+) AAGAG-/CACACAC 1 -- ds50010--------
    rs1812669251,2
    --48700889(+) GCACAC/TACACA 1 -- ds50010--------
    rs1502449501,2
    C--48700956(+) AAGAAA/CATTTT 1 -- ds50010--------
    rs1389142231,2
    --48700963(+) TTTTCA/GATTCT 1 -- ds50010--------
    rs115393021,2
    C,H--48701232(+) CAAAAG/TAGTGT 1 -- ut312Minor allele frequency- T:0.00NS NA 282
    rs1850217261,2
    --48701299(+) TTTTAG/TAAACA 1 -- ut310--------
    rs772371231,2
    C,F--48701332(+) GATTCC/GTTGGC 1 -- ut311Minor allele frequency- G:0.06WA 118
    rs1894856991,2
    --48701602(+) TACTAC/TTGAAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MEX3C (48700920 - 48744674 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MEX3C:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833652CNV Loss17160897
    nsv909645CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MEX3C
    DNA2.0 Custom Variant and Variant Library Synthesis for MEX3C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611005    OMIM disorders: --

    UniProtKB/Swiss-Prot: MEX3C_HUMAN, Q5U5Q3
  • Note=Genetic variations in MEX3C may be associated with susceptibility to essential hypertension

  • 5 diseases for MEX3C:    
    About MalaCards
    hypertension    smallpox    essential hypertension    multiple myeloma
    myeloma


    MEX3C for disorders           About GeneDecksing

    Genetic Association Database (GAD): MEX3C
    Human Genome Epidemiology (HuGE) Navigator: MEX3C (1 document)

    Export disorders for MEX3C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MEX3C gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with MEX3C)
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    1. Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. (PubMed id 17267406)1, 2, 3 Buchet-Poyau K.... Billaud M. (Nucleic Acids Res. 2007)
    2. The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation. (PubMed id 22863774)1, 2 Cano F....Lehner P.J. (EMBO J. 2012)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Implication of chromosome 18 in hypertension by sibling pair and association analyses: putative involvement of the RKHD2 gene. (PubMed id 17015768)1, 2 Guzman B....Poch E. (Hypertension 2006)
    5. DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)1, 2 Nusbaum C.... Lander E.S. (Nature 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Replication stress links structural and numerical cancer chromosomal instability. (PubMed id 23446422)2 Burrell R.A.... Swanton C. (Nature 2013)
    8. A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed. (PubMed id 22658931)1 Pajewski N.M....Kaslow R.A. (Vaccine 2012)
    9. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PubMed id 22610502)1 Kennedy R.B....Poland G.A. (Hum. Genet. 2012)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51320 HGNC: 28040 AceView: RKHD2 Ensembl:ENSG00000176624 euGenes: HUgn51320
    ECgene: MEX3C H-InvDB: MEX3C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MEX3C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MEX3C gene:
    Search GeneIP for patents involving MEX3C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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