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Aliases for MEX3C Gene

Aliases for MEX3C Gene

  • Mex-3 RNA Binding Family Member C 2 3
  • RKHD2 3 4 6
  • RING Finger And KH Domain-Containing Protein 2 3 4
  • Ring Finger And KH Domain Containing 2 2 3
  • RING Finger Protein 194 3 4
  • RNF194 3 4
  • RNA-Binding E3 Ubiquitin-Protein Ligase MEX3C 3
  • Mex-3 Homolog C (C. Elegans) 2
  • RNA-Binding Protein MEX3C 3
  • EC 6.3.2.- 4
  • BM-013 3
  • MEX-3C 3

External Ids for MEX3C Gene

Previous HGNC Symbols for MEX3C Gene

  • RKHD2

Previous GeneCards Identifiers for MEX3C Gene

  • GC18M046955
  • GC18M048700
  • GC18M045556

Summaries for MEX3C Gene

Entrez Gene Summary for MEX3C Gene

  • This gene encodes a member of a family of proteins with two K homology (KH) RNA-binding domains and a C-terminal RING-finger domain. The protein interacts with mRNA via the KH domains, and the protein shuttles between the nucleus and cytoplasm. Polymorphisms in this gene may contribute to hypertension. [provided by RefSeq, Oct 2009]

GeneCards Summary for MEX3C Gene

MEX3C (Mex-3 RNA Binding Family Member C) is a Protein Coding gene. GO annotations related to this gene include RNA binding and ligase activity. An important paralog of this gene is MEX3D.

UniProtKB/Swiss-Prot for MEX3C Gene

  • E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3 UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEX3C Gene

Genomics for MEX3C Gene

Regulatory Elements for MEX3C Gene

Genomic Location for MEX3C Gene

51,174,550 bp from pter
51,218,304 bp from pter
43,755 bases
Minus strand

Genomic View for MEX3C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MEX3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEX3C Gene

Proteins for MEX3C Gene

  • Protein details for MEX3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA-binding E3 ubiquitin-protein ligase MEX3C
    Protein Accession:
    Secondary Accessions:
    • A1L022
    • Q9NZE3

    Protein attributes for MEX3C Gene

    659 amino acids
    Molecular mass:
    69366 Da
    Quaternary structure:
    • Interacts with USP7, which antagonizes the ability to degrade mRNA.
    • Sequence=AAF64269.1; Type=Erroneous termination; Positions=514; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=AAF64269.1; Type=Frameshift; Positions=520, 525; Evidence={ECO:0000305};

neXtProt entry for MEX3C Gene

Proteomics data for MEX3C Gene at MOPED

Post-translational modifications for MEX3C Gene

  • Ubiquitination at Lys309
  • Modification sites at PhosphoSitePlus

Other Protein References for MEX3C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MEX3C Gene

Domains for MEX3C Gene

Gene Families for MEX3C Gene

  • MEX3 :Mex-3 homologs
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for MEX3C Gene

Suggested Antigen Peptide Sequences for MEX3C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q5U5Q3
  • Binds RNA through its KH domains
  • Contains 2 KH domains.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with MEX3C: view

Function for MEX3C Gene

Molecular function for MEX3C Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3 UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation.

Enzyme Numbers (IUBMB) for MEX3C Gene

Gene Ontology (GO) - Molecular Function for MEX3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding --
GO:0005515 protein binding IPI 22863774
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with MEX3C: view
genes like me logo Genes that share phenotypes with MEX3C: view

miRNA for MEX3C Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MEX3C Gene

Localization for MEX3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEX3C Gene

Cytoplasm. Nucleus. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. May act as suppressor of replication stress and chromosome missegregation.

Subcellular locations from

Jensen Localization Image for MEX3C Gene COMPARTMENTS Subcellular localization image for MEX3C gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for MEX3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MEX3C: view

Pathways for MEX3C Gene

SuperPathways for MEX3C Gene

No Data Available

Gene Ontology (GO) - Biological Process for MEX3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003415 chondrocyte hypertrophy IEA --
GO:0008152 metabolic process IEA --
GO:0045598 regulation of fat cell differentiation IEA --
GO:0097009 energy homeostasis IEA --
GO:0098779 activation of mitophagy in response to mitochondrial depolarization IMP 22020285
genes like me logo Genes that share ontologies with MEX3C: view

No data available for Pathways by source for MEX3C Gene

Compounds for MEX3C Gene

(1) PharmGKB related drug/compound annotations for MEX3C Gene

Drug/compound Annotation
Bisphosphonates CA
genes like me logo Genes that share compounds with MEX3C: view

Transcripts for MEX3C Gene

mRNA/cDNA for MEX3C Gene

Unigene Clusters for MEX3C Gene

Mex-3 homolog C (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MEX3C Gene

No ASD Table

Relevant External Links for MEX3C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MEX3C Gene

mRNA expression in normal human tissues for MEX3C Gene

mRNA differential expression in normal tissues according to GTEx for MEX3C Gene

This gene is overexpressed in Testis (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MEX3C Gene

SOURCE GeneReport for Unigene cluster for MEX3C Gene Hs.465144

mRNA Expression by UniProt/SwissProt for MEX3C Gene

Tissue specificity: Highest levels found in fetal brain and testis. Also expressed in thymus, salivary gland and uterus. Highly expressed in cells of the innate immune system, in particular activated NK cells. Week expression in the intestine.
genes like me logo Genes that share expressions with MEX3C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MEX3C Gene

Orthologs for MEX3C Gene

This gene was present in the common ancestor of animals.

Orthologs for MEX3C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MEX3C 35
  • 99.78 (n)
  • 100 (a)
MEX3C 36
  • 98 (a)
(Bos Taurus)
Mammalia MEX3C 35
  • 94.1 (n)
  • 99.22 (a)
MEX3C 36
  • 99 (a)
(Canis familiaris)
Mammalia MEX3C 35
  • 93.04 (n)
  • 95.44 (a)
MEX3C 36
  • 75 (a)
(Mus musculus)
Mammalia Mex3c 35
  • 92.22 (n)
  • 95.79 (a)
Mex3c 16
Mex3c 36
  • 78 (a)
(Monodelphis domestica)
Mammalia MEX3C 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia MEX3C 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Mex3c 35
  • 94.04 (n)
  • 99.57 (a)
(Anolis carolinensis)
Reptilia MEX3C 36
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mex3c 35
  • 74.69 (n)
  • 82.01 (a)
Str.993 35
(Danio rerio)
Actinopterygii MEX3C 36
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11360 36
  • 32 (a)
(Caenorhabditis elegans)
Secernentea mex-3 36
  • 37 (a)
Species with no ortholog for MEX3C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MEX3C Gene

Gene Tree for MEX3C (if available)
Gene Tree for MEX3C (if available)

Paralogs for MEX3C Gene

Paralogs for MEX3C Gene

Selected SIMAP similar genes for MEX3C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MEX3C: view

Variants for MEX3C Gene

Sequence variations from dbSNP and Humsavar for MEX3C Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs12454 -- 51,176,554(+) GGAAC(A/C)ACCAT reference, missense
rs1080169 -- 51,174,082(-) ACCTT(C/T)TGAAA downstream-variant-500B
rs1893378 -- 51,192,490(-) GTGTC(C/T)AGCTA intron-variant
rs1893379 -- 51,192,166(-) TGATC(C/T)AGGGA intron-variant
rs2027696 -- 51,193,541(-) GAACG(C/T)CTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MEX3C Gene

Variant ID Type Subtype PubMed ID
nsv909645 CNV Gain 21882294
nsv833652 CNV Loss 17160897

Relevant External Links for MEX3C Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEX3C Gene

Disorders for MEX3C Gene


  • Note=Genetic variations in MEX3C may be associated with susceptibility to essential hypertension.

Relevant External Links for MEX3C

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MEX3C: view

Publications for MEX3C Gene

  1. Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. (PMID: 17267406) Buchet-Poyau K. … Billaud M. (Nucleic Acids Res. 2007) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C. … Lander E.S. (Nature 2005) 3 4
  4. Implication of chromosome 18 in hypertension by sibling pair and association analyses: putative involvement of the RKHD2 gene. (PMID: 17015768) Guzman B. … Poch E. (Hypertension 2006) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for MEX3C Gene

Sources for MEX3C Gene

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