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Aliases for MEX3B Gene

Aliases for MEX3B Gene

  • Mex-3 RNA Binding Family Member B 2 3
  • RKHD3 3 4 6
  • Ring Finger And KH Domain Containing 3 2 3
  • RING Finger Protein 195 3 4
  • RNF195 3 4
  • RING Finger And KH Domain-Containing Protein 3 4
  • Mex-3 Homolog B (C. Elegans) 2
  • RNA-Binding Protein MEX3B 3
  • KIAA2009 4
  • MEX-3B 3

External Ids for MEX3B Gene

Previous HGNC Symbols for MEX3B Gene

  • RKHD3

Previous GeneCards Identifiers for MEX3B Gene

  • GC15M080122
  • GC15M082334
  • GC15M059092

Summaries for MEX3B Gene

Entrez Gene Summary for MEX3B Gene

  • This gene encodes an RNA-binding phosphoprotein that is part of the MEX3 (muscle excess 3) family of translational regulators. The encoded protein contains N-terminal nuclear export and nuclear localization signals and is exported from the cytoplasm to the nucleus. The protein binds to RNA via two KH domains and also colocalizes with MEX3A, Dcp1A decapping factor and Argonaute proteins within P (processing) bodies. [provided by RefSeq, Oct 2012]

GeneCards Summary for MEX3B Gene

MEX3B (Mex-3 RNA Binding Family Member B) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and RNA binding. An important paralog of this gene is MEX3D.

UniProtKB/Swiss-Prot for MEX3B Gene

  • RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms

Gene Wiki entry for MEX3B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEX3B Gene

Genomics for MEX3B Gene

Regulatory Elements for MEX3B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MEX3B Gene

Start:
82,041,778 bp from pter
End:
82,046,143 bp from pter
Size:
4,366 bases
Orientation:
Minus strand

Genomic View for MEX3B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MEX3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEX3B Gene

Proteins for MEX3B Gene

  • Protein details for MEX3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZN04-MEX3B_HUMAN
    Recommended name:
    RNA-binding protein MEX3B
    Protein Accession:
    Q6ZN04
    Secondary Accessions:
    • Q4G0W1
    • Q8IVG2
    • Q9H0J0

    Protein attributes for MEX3B Gene

    Size:
    569 amino acids
    Molecular mass:
    58832 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC23105.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for MEX3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEX3B Gene

Proteomics data for MEX3B Gene at MOPED

Post-translational modifications for MEX3B Gene

  • Phosphorylation at Ser-462 creates a docking site for 14-3-3, which stabilizes the protein and modulates its ability to bind RNA.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MEX3B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MEX3B Gene

Domains for MEX3B Gene

Gene Families for MEX3B Gene

HGNC:
  • MEX3 :Mex-3 homologs
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for MEX3B Gene

Suggested Antigen Peptide Sequences for MEX3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZN04

UniProtKB/Swiss-Prot:

MEX3B_HUMAN :
  • Q6ZN04
Domain:
  • Binds RNA through its KH domains
  • Contains 2 KH domains.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with MEX3B: view

Function for MEX3B Gene

Molecular function for MEX3B Gene

UniProtKB/Swiss-Prot Function: RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms

Gene Ontology (GO) - Molecular Function for MEX3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding --
GO:0005509 calcium ion binding ISS --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MEX3B: view

Animal Model Products

CRISPR Products

miRNA for MEX3B Gene

miRTarBase miRNAs that target MEX3B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MEX3B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MEX3B Gene

Localization for MEX3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEX3B Gene

Nucleus. Cytoplasm. Cytoplasm, P-body. Cytoplasmic granule. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. Localization to P-bodies is dependent on 14-3-3.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MEX3B Gene COMPARTMENTS Subcellular localization image for MEX3B gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for MEX3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IEA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with MEX3B: view

Pathways for MEX3B Gene

SuperPathways for MEX3B Gene

No Data Available

Gene Ontology (GO) - Biological Process for MEX3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation ISS --
GO:0046777 protein autophosphorylation ISS --
genes like me logo Genes that share ontologies with MEX3B: view

No data available for Pathways by source for MEX3B Gene

Transcripts for MEX3B Gene

mRNA/cDNA for MEX3B Gene

Unigene Clusters for MEX3B Gene

Mex-3 homolog B (C. elegans):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MEX3B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MEX3B
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEX3B Gene

No ASD Table

Relevant External Links for MEX3B Gene

GeneLoc Exon Structure for
MEX3B
ECgene alternative splicing isoforms for
MEX3B

Expression for MEX3B Gene

mRNA expression in normal human tissues for MEX3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEX3B Gene

This gene is overexpressed in Testis (17.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MEX3B Gene

SOURCE GeneReport for Unigene cluster for MEX3B Gene Hs.104744

mRNA Expression by UniProt/SwissProt for MEX3B Gene

Q6ZN04-MEX3B_HUMAN
Tissue specificity: Highest levels found in fetal brain and testis. Detected in the adult intestinal epithelium, specifically in goblet cell at protein level.
genes like me logo Genes that share expressions with MEX3B: view

In Situ Assay Products

Orthologs for MEX3B Gene

This gene was present in the common ancestor of animals.

Orthologs for MEX3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEX3B 35
  • 99.06 (n)
  • 98.77 (a)
MEX3B 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MEX3B 35
  • 89.05 (n)
  • 95.28 (a)
MEX3B 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MEX3B 35
  • 91.14 (n)
  • 97.71 (a)
MEX3B 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mex3b 35
  • 88.85 (n)
  • 97.89 (a)
Mex3b 16
Mex3b 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MEX3B 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mex3b 35
  • 88.67 (n)
  • 97.36 (a)
lizard
(Anolis carolinensis)
Reptilia MEX3B 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mex3b 35
  • 74.84 (n)
  • 82.35 (a)
zebrafish
(Danio rerio)
Actinopterygii mex3b 35
  • 73.06 (n)
  • 79.46 (a)
mex3b 36
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11360 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mex-3 36
  • 35 (a)
OneToMany
Species with no ortholog for MEX3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MEX3B Gene

ENSEMBL:
Gene Tree for MEX3B (if available)
TreeFam:
Gene Tree for MEX3B (if available)

Paralogs for MEX3B Gene

Paralogs for MEX3B Gene

Selected SIMAP similar genes for MEX3B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MEX3B: view

Variants for MEX3B Gene

Sequence variations from dbSNP and Humsavar for MEX3B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs957942 -- 82,041,707(-) ACAAG(C/T)TGAAA downstream-variant-500B
rs2457498 -- 82,045,968(+) GGCCG(C/G)GCGTG utr-variant-5-prime
rs7171792 -- 82,047,854(+) ACGCG(A/G)TGGTG upstream-variant-2KB
rs12914890 -- 82,047,414(+) CGCCC(C/T)TTCGG upstream-variant-2KB
rs12915030 -- 82,047,485(+) TCCCG(A/C)TGCGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MEX3B Gene

Variant ID Type Subtype PubMed ID
nsv833067 CNV Gain+Loss 17160897
esv2422504 CNV Duplication 17116639
nsv827415 CNV Gain 20364138

Relevant External Links for MEX3B Gene

HapMap Linkage Disequilibrium report
MEX3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEX3B Gene

Disorders for MEX3B Gene

Relevant External Links for MEX3B

Genetic Association Database (GAD)
MEX3B
genes like me logo Genes that share disorders with MEX3B: view

No data available for UniProtKB/Swiss-Prot for MEX3B Gene

Publications for MEX3B Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  2. Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. (PMID: 17267406) Buchet-Poyau K. … Billaud M. (Nucleic Acids Res. 2007) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Interaction with 14-3-3 adaptors regulates the sorting of hMex-3B RNA-binding protein to distinct classes of RNA granules. (PMID: 18779327) Courchet J. … Billaud M. (J. Biol. Chem. 2008) 3 4

Products for MEX3B Gene

  • Addgene plasmids for MEX3B

Sources for MEX3B Gene

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