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Aliases for MEX3B Gene

Aliases for MEX3B Gene

  • Mex-3 RNA Binding Family Member B 2 3 5
  • Ring Finger And KH Domain Containing 3 2 3
  • RING Finger Protein 195 3 4
  • RNF195 3 4
  • RKHD3 3 4
  • RING Finger And KH Domain-Containing Protein 3 4
  • Mex-3 Homolog B (C. Elegans) 2
  • RNA-Binding Protein MEX3B 3
  • KIAA2009 4
  • MEX-3B 3

External Ids for MEX3B Gene

Previous HGNC Symbols for MEX3B Gene

  • RKHD3

Previous GeneCards Identifiers for MEX3B Gene

  • GC15M080122
  • GC15M082334
  • GC15M059092

Summaries for MEX3B Gene

Entrez Gene Summary for MEX3B Gene

  • This gene encodes an RNA-binding phosphoprotein that is part of the MEX3 (muscle excess 3) family of translational regulators. The encoded protein contains N-terminal nuclear export and nuclear localization signals and is exported from the cytoplasm to the nucleus. The protein binds to RNA via two KH domains and also colocalizes with MEX3A, Dcp1A decapping factor and Argonaute proteins within P (processing) bodies. [provided by RefSeq, Oct 2012]

GeneCards Summary for MEX3B Gene

MEX3B (Mex-3 RNA Binding Family Member B) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and calcium ion binding. An important paralog of this gene is MEX3C.

UniProtKB/Swiss-Prot for MEX3B Gene

  • RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms.

Gene Wiki entry for MEX3B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEX3B Gene

Genomics for MEX3B Gene

Regulatory Elements for MEX3B Gene

Enhancers for MEX3B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F081951 1.2 Ensembl ENCODE 11.4 +94.9 94943 0.4 PKNOX1 ZNF133 FEZF1 ZNF2 ZNF302 GATA2 KLF7 SP3 NCOA1 TSHZ1 MEX3B GC15P081965 GC15P081908
GH15F082043 1.4 FANTOM5 ENCODE 9.4 +0.1 72 5.7 PKNOX1 CREB3L1 SIN3A ZNF2 ZNF143 KLF13 ZNF263 SP3 NFYC REST SNHG21 MEX3B ENSG00000259445 LOC105370923
GH15F081942 0.9 ENCODE 11.7 +103.8 103769 0.2 HDAC1 PKNOX1 CBX3 ATF1 TBL1XR1 CHAMP1 GATA2 SIRT6 ETV6 NCOA1 MEX3B GC15P081965 GC15P081908
GH15F081944 0.9 ENCODE 11.7 +101.0 101027 0.9 HDAC1 CBX3 ATF1 TBL1XR1 CHAMP1 GATA2 CREM ZBTB2 NCOA1 ZEB2 MEX3B GC15P081965 GC15P081908
GH15F081947 0.9 Ensembl ENCODE 11.4 +98.1 98059 1.0 RNF2 MTA2 TAL1 CEBPB ZEB2 ARID1B GATA2 NCOR1 SMARCA4 IKZF1 MEX3B GC15P081965 GC15P081908
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MEX3B on UCSC Golden Path with GeneCards custom track

Promoters for MEX3B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000651175 343 4801 PKNOX1 CREB3L1 SIN3A ZNF2 ZNF143 KLF13 ZNF263 SP3 NFYC REST

Genomic Location for MEX3B Gene

Chromosome:
15
Start:
82,041,778 bp from pter
End:
82,046,143 bp from pter
Size:
4,366 bases
Orientation:
Minus strand

Genomic View for MEX3B Gene

Genes around MEX3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEX3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEX3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEX3B Gene

Proteins for MEX3B Gene

  • Protein details for MEX3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZN04-MEX3B_HUMAN
    Recommended name:
    RNA-binding protein MEX3B
    Protein Accession:
    Q6ZN04
    Secondary Accessions:
    • Q4G0W1
    • Q8IVG2
    • Q9H0J0

    Protein attributes for MEX3B Gene

    Size:
    569 amino acids
    Molecular mass:
    58832 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC23105.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for MEX3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEX3B Gene

Post-translational modifications for MEX3B Gene

  • Phosphorylation at Ser-462 creates a docking site for 14-3-3, which stabilizes the protein and modulates its ability to bind RNA.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MEX3B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for MEX3B
  • Santa Cruz Biotechnology (SCBT) Antibodies for MEX3B

No data available for DME Specific Peptides for MEX3B Gene

Domains & Families for MEX3B Gene

Gene Families for MEX3B Gene

Protein Domains for MEX3B Gene

Suggested Antigen Peptide Sequences for MEX3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZN04

UniProtKB/Swiss-Prot:

MEX3B_HUMAN :
  • Binds RNA through its KH domains.
  • Contains 1 RING-type zinc finger.
Domain:
  • Binds RNA through its KH domains.
  • Contains 2 KH domains.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with MEX3B: view

Function for MEX3B Gene

Molecular function for MEX3B Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms.

Gene Ontology (GO) - Molecular Function for MEX3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0005509 calcium ion binding ISS --
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with MEX3B: view
genes like me logo Genes that share phenotypes with MEX3B: view

Animal Models for MEX3B Gene

MGI Knock Outs for MEX3B:

Animal Model Products

miRNA for MEX3B Gene

miRTarBase miRNAs that target MEX3B

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MEX3B

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MEX3B Gene

Localization for MEX3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEX3B Gene

Nucleus. Cytoplasm. Cytoplasm, P-body. Cytoplasmic granule. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. Localization to P-bodies is dependent on 14-3-3.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEX3B gene
Compartment Confidence
nucleus 5
cytosol 5
endosome 1

Gene Ontology (GO) - Cellular Components for MEX3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MEX3B: view

Pathways & Interactions for MEX3B Gene

SuperPathways for MEX3B Gene

No Data Available

Gene Ontology (GO) - Biological Process for MEX3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation ISS --
GO:0046777 protein autophosphorylation ISS --
genes like me logo Genes that share ontologies with MEX3B: view

No data available for Pathways by source and SIGNOR curated interactions for MEX3B Gene

Transcripts for MEX3B Gene

mRNA/cDNA for MEX3B Gene

Unigene Clusters for MEX3B Gene

Mex-3 homolog B (C. elegans):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MEX3B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEX3B Gene

No ASD Table

Relevant External Links for MEX3B Gene

GeneLoc Exon Structure for
MEX3B
ECgene alternative splicing isoforms for
MEX3B

Expression for MEX3B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MEX3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEX3B Gene

This gene is overexpressed in Testis (x17.0).

Protein differential expression in normal tissues from HIPED for MEX3B Gene

This gene is overexpressed in Platelet (44.1) and Saliva (24.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MEX3B Gene



Protein tissue co-expression partners for MEX3B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MEX3B Gene:

MEX3B

SOURCE GeneReport for Unigene cluster for MEX3B Gene:

Hs.104744

mRNA Expression by UniProt/SwissProt for MEX3B Gene:

Q6ZN04-MEX3B_HUMAN
Tissue specificity: Highest levels found in fetal brain and testis. Detected in the adult intestinal epithelium, specifically in goblet cell at protein level.
genes like me logo Genes that share expression patterns with MEX3B: view

Primer Products

Orthologs for MEX3B Gene

This gene was present in the common ancestor of animals.

Orthologs for MEX3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEX3B 34 35
  • 99.06 (n)
dog
(Canis familiaris)
Mammalia MEX3B 34 35
  • 91.14 (n)
cow
(Bos Taurus)
Mammalia MEX3B 34 35
  • 89.05 (n)
mouse
(Mus musculus)
Mammalia Mex3b 34 16 35
  • 88.85 (n)
rat
(Rattus norvegicus)
Mammalia Mex3b 34
  • 88.67 (n)
oppossum
(Monodelphis domestica)
Mammalia MEX3B 35
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MEX3B 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mex3b 34
  • 74.84 (n)
zebrafish
(Danio rerio)
Actinopterygii mex3b 34 35
  • 73.06 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11360 35
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mex-3 35
  • 35 (a)
OneToMany
Species where no ortholog for MEX3B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MEX3B Gene

ENSEMBL:
Gene Tree for MEX3B (if available)
TreeFam:
Gene Tree for MEX3B (if available)

Paralogs for MEX3B Gene

Paralogs for MEX3B Gene

(3) SIMAP similar genes for MEX3B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MEX3B: view

Variants for MEX3B Gene

Sequence variations from dbSNP and Humsavar for MEX3B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs11073028 -- 82,043,103(+) AGAGG(A/G)TGGGG utr-variant-3-prime
rs111472942 -- 82,047,840(+) CTTTA(C/T)TTTTG upstream-variant-2KB
rs111875167 -- 82,047,424(+) GGCCC(-/CG)CGCGC upstream-variant-2KB
rs111907746 -- 82,043,670(+) GAAGA(C/T)GCAGA reference, synonymous-codon
rs112549201 -- 82,041,591(+) CAATT(C/T)TTAGA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MEX3B Gene

Variant ID Type Subtype PubMed ID
nsv833067 CNV gain+loss 17160897
nsv827415 CNV gain 20364138
nsv1070287 CNV deletion 25765185
esv2422504 CNV duplication 17116639

Variation tolerance for MEX3B Gene

Residual Variation Intolerance Score: 5.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MEX3B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEX3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEX3B Gene

Disorders for MEX3B Gene

Relevant External Links for MEX3B

Genetic Association Database (GAD)
MEX3B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MEX3B

No disorders were found for MEX3B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEX3B Gene

Publications for MEX3B Gene

  1. Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. (PMID: 17267406) Buchet-Poyau K. … Billaud M. (Nucleic Acids Res. 2007) 2 3 4 64
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
  3. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. (PMID: 19079261) Willer C.J. … Hirschhorn J.N. (Nat. Genet. 2009) 3 46 64
  4. Interaction with 14-3-3 adaptors regulates the sorting of hMex-3B RNA-binding protein to distinct classes of RNA granules. (PMID: 18779327) Courchet J. … Billaud M. (J. Biol. Chem. 2008) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for MEX3B Gene

Sources for MEX3B Gene

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