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Aliases for MEX3B Gene

Aliases for MEX3B Gene

  • Mex-3 RNA Binding Family Member B 2 3 5
  • Ring Finger And KH Domain Containing 3 2 3
  • RING Finger Protein 195 3 4
  • RNF195 3 4
  • RKHD3 3 4
  • RING Finger And KH Domain-Containing Protein 3 4
  • Mex-3 Homolog B (C. Elegans) 2
  • KIAA2009 4
  • MEX-3B 3

External Ids for MEX3B Gene

Previous HGNC Symbols for MEX3B Gene

  • RKHD3

Previous GeneCards Identifiers for MEX3B Gene

  • GC15M080122
  • GC15M082334
  • GC15M059092

Summaries for MEX3B Gene

Entrez Gene Summary for MEX3B Gene

  • This gene encodes an RNA-binding phosphoprotein that is part of the MEX3 (muscle excess 3) family of translational regulators. The encoded protein contains N-terminal nuclear export and nuclear localization signals and is exported from the cytoplasm to the nucleus. The protein binds to RNA via two KH domains and also colocalizes with MEX3A, Dcp1A decapping factor and Argonaute proteins within P (processing) bodies. [provided by RefSeq, Oct 2012]

GeneCards Summary for MEX3B Gene

MEX3B (Mex-3 RNA Binding Family Member B) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and calcium ion binding. An important paralog of this gene is MEX3D.

UniProtKB/Swiss-Prot for MEX3B Gene

  • RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms.

Gene Wiki entry for MEX3B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEX3B Gene

Genomics for MEX3B Gene

Regulatory Elements for MEX3B Gene

Enhancers for MEX3B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MEX3B on UCSC Golden Path with GeneCards custom track

Promoters for MEX3B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MEX3B on UCSC Golden Path with GeneCards custom track

Genomic Location for MEX3B Gene

82,041,778 bp from pter
82,046,143 bp from pter
4,366 bases
Minus strand

Genomic View for MEX3B Gene

Genes around MEX3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEX3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEX3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEX3B Gene

Proteins for MEX3B Gene

  • Protein details for MEX3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA-binding protein MEX3B
    Protein Accession:
    Secondary Accessions:
    • Q4G0W1
    • Q8IVG2
    • Q9H0J0

    Protein attributes for MEX3B Gene

    569 amino acids
    Molecular mass:
    58832 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC23105.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for MEX3B Gene


neXtProt entry for MEX3B Gene

Proteomics data for MEX3B Gene at MOPED

Post-translational modifications for MEX3B Gene

  • Phosphorylation at Ser-462 creates a docking site for 14-3-3, which stabilizes the protein and modulates its ability to bind RNA.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MEX3B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MEX3B Gene

Domains & Families for MEX3B Gene

Gene Families for MEX3B Gene

Protein Domains for MEX3B Gene

Suggested Antigen Peptide Sequences for MEX3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Binds RNA through its KH domains.
  • Contains 1 RING-type zinc finger.
  • Binds RNA through its KH domains.
  • Contains 2 KH domains.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with MEX3B: view

Function for MEX3B Gene

Molecular function for MEX3B Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms.

Gene Ontology (GO) - Molecular Function for MEX3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding ISS --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with MEX3B: view
genes like me logo Genes that share phenotypes with MEX3B: view

Animal Model Products

miRNA for MEX3B Gene

miRTarBase miRNAs that target MEX3B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MEX3B Gene

Localization for MEX3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEX3B Gene

Nucleus. Cytoplasm. Cytoplasm, P-body. Cytoplasmic granule. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. Localization to P-bodies is dependent on 14-3-3.

Subcellular locations from

Jensen Localization Image for MEX3B Gene COMPARTMENTS Subcellular localization image for MEX3B gene
Compartment Confidence
nucleus 5
cytosol 3
endosome 1

No data available for Gene Ontology (GO) - Cellular Components for MEX3B Gene

Pathways & Interactions for MEX3B Gene

SuperPathways for MEX3B Gene

No Data Available

Gene Ontology (GO) - Biological Process for MEX3B Gene


No data available for Pathways by source and SIGNOR curated interactions for MEX3B Gene

Drugs & Compounds for MEX3B Gene

No Compound Related Data Available

Transcripts for MEX3B Gene

mRNA/cDNA for MEX3B Gene

Unigene Clusters for MEX3B Gene

Mex-3 homolog B (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MEX3B Gene

No ASD Table

Relevant External Links for MEX3B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MEX3B Gene

mRNA expression in normal human tissues for MEX3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEX3B Gene

This gene is overexpressed in Testis (x17.0).

Protein differential expression in normal tissues from HIPED for MEX3B Gene

This gene is overexpressed in Platelet (44.1) and Saliva (24.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MEX3B Gene

SOURCE GeneReport for Unigene cluster for MEX3B Gene Hs.104744

mRNA Expression by UniProt/SwissProt for MEX3B Gene

Tissue specificity: Highest levels found in fetal brain and testis. Detected in the adult intestinal epithelium, specifically in goblet cell at protein level.
genes like me logo Genes that share expression patterns with MEX3B: view

Protein tissue co-expression partners for MEX3B Gene

- Elite partner

Primer Products

Orthologs for MEX3B Gene

This gene was present in the common ancestor of animals.

Orthologs for MEX3B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MEX3B 35
  • 89.05 (n)
  • 95.28 (a)
MEX3B 36
  • 90 (a)
(Canis familiaris)
Mammalia MEX3B 35
  • 91.14 (n)
  • 97.71 (a)
MEX3B 36
  • 91 (a)
(Mus musculus)
Mammalia Mex3b 35
  • 88.85 (n)
  • 97.89 (a)
Mex3b 16
Mex3b 36
  • 93 (a)
(Pan troglodytes)
Mammalia MEX3B 35
  • 99.06 (n)
  • 98.77 (a)
MEX3B 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Mex3b 35
  • 88.67 (n)
  • 97.36 (a)
(Monodelphis domestica)
Mammalia MEX3B 36
  • 85 (a)
(Anolis carolinensis)
Reptilia MEX3B 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mex3b 35
  • 74.84 (n)
  • 82.35 (a)
(Danio rerio)
Actinopterygii mex3b 35
  • 73.06 (n)
  • 79.46 (a)
mex3b 36
  • 70 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11360 36
  • 32 (a)
(Caenorhabditis elegans)
Secernentea mex-3 36
  • 35 (a)
Species with no ortholog for MEX3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MEX3B Gene

Gene Tree for MEX3B (if available)
Gene Tree for MEX3B (if available)

Paralogs for MEX3B Gene

Paralogs for MEX3B Gene

(3) SIMAP similar genes for MEX3B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MEX3B: view

Variants for MEX3B Gene

Sequence variations from dbSNP and Humsavar for MEX3B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs957942 -- 82,041,707(-) ACAAG(C/T)TGAAA downstream-variant-500B
rs7171792 -- 82,047,854(+) ACGCG(A/G)TGGTG upstream-variant-2KB
rs58518330 -- 82,041,463(+) TATGT(C/T)AATTT downstream-variant-500B
rs12914890 -- 82,047,414(+) CGCCC(C/T)TTCGG upstream-variant-2KB
rs12915030 -- 82,047,485(+) TCCCG(A/C)TGCGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MEX3B Gene

Variant ID Type Subtype PubMed ID
nsv833067 CNV Gain+Loss 17160897
esv2422504 CNV Duplication 17116639
nsv827415 CNV Gain 20364138

Variation tolerance for MEX3B Gene

Residual Variation Intolerance Score: 5.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.21% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MEX3B Gene

Disorders for MEX3B Gene

Relevant External Links for MEX3B

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MEX3B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEX3B Gene

Publications for MEX3B Gene

  1. Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. (PMID: 17267406) Buchet-Poyau K. … Billaud M. (Nucleic Acids Res. 2007) 2 3 4 67
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A genome-wide association study of clinical symptoms of dissociation in a trauma-exposed sample. (PMID: 24677629) Wolf E.J. … Miller M.W. (Depress Anxiety 2014) 3
  5. Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination. (PMID: 24326307) Yoon J.H. … Gorospe M. (Nat Commun 2013) 3

Products for MEX3B Gene

Sources for MEX3B Gene