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MEX3B Gene

protein-coding   GIFtS: 50
GCID: GC15M082334

Mex-3 RNA Binding Family Member B

(Previous names: ring finger and KH domain containing 3, mex-3 homolog B...)
(Previous symbol: RKHD3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mex-3 RNA Binding Family Member B1 2     Mex-3 Homolog B (C. Elegans)1
RKHD31 2 3 5     MEX-3B2
Ring Finger And KH Domain Containing 31 2     RNA-Binding Protein MEX3B2
RNF1952 3     KIAA20093
RING Finger Protein 1952 3     RING Finger And KH Domain-Containing Protein 33

External Ids:    HGNC: 252971   Entrez Gene: 842062   Ensembl: ENSG000001834967   OMIM: 6110085   UniProtKB: Q6ZN043   

Export aliases for MEX3B gene to outside databases

Previous GC identifers: GC15M080122 GC15M059092


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MEX3B Gene:
This gene encodes an RNA-binding phosphoprotein that is part of the MEX3 (muscle excess 3) family of translational
regulators. The encoded protein contains N-terminal nuclear export and nuclear localization signals and is
exported from the cytoplasm to the nucleus. The protein binds to RNA via two KH domains and also colocalizes with
MEX3A, Dcp1A decapping factor and Argonaute proteins within P (processing) bodies. (provided by RefSeq, Oct 2012)

GeneCards Summary for MEX3B Gene:
MEX3B (mex-3 RNA binding family member B) is a protein-coding gene. Diseases associated with MEX3B include cerebellar ataxia, and ataxia. GO annotations related to this gene include RNA binding and calcium ion binding. An important paralog of this gene is MEX3A.

UniProtKB/Swiss-Prot: MEX3B_HUMAN, Q6ZN04
Function: RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms

Gene Wiki entry for MEX3B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the MEX3B gene promoter:
         HOXA9B   HOXA9   Max1   AhR   Pax-5   p300   Pax-2   Pax-2a   Arnt   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMEX3B promoter sequence
   Search Chromatin IP Primers for MEX3B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MEX3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25.2   Ensembl cytogenetic band:  15q25.2   HGNC cytogenetic band: 15q25.1

MEX3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEX3B gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M082334:  view genomic region     (about GC identifiers)

Start:
82,334,119 bp from pter      End:
82,338,482 bp from pter
Size:
4,364 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MEX3B_HUMAN, Q6ZN04 (See protein sequence)
Recommended Name: RNA-binding protein MEX3B  
Size: 569 amino acids; 58832 Da
Sequence caution: Sequence=BAC23105.1; Type=Erroneous translation; Note=Wrong choice of CDS;
Secondary accessions: Q4G0W1 Q8IVG2 Q9H0J0
Alternative splicing: 2 isoforms:  Q6ZN04-1   Q6ZN04-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MEX3B: NX_Q6ZN04

Explore proteomics data for MEX3B at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-462 creates a docking site for 14-3-3, which stabilizes the protein and modulates its
    ability to bind RNA1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MEX3B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115622.2  
    ENSEMBL proteins: 
     ENSP00000329918   ENSP00000456938  

    MEX3B Human Recombinant Protein Products:

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    Novus Biologicals MEX3B Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    MEX3B Antibody Products:

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    MEX3B Assay Products:

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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MEX3: Mex-3 homologs
    RNF: RING-type (C3HC4) zinc fingers

    4 InterPro protein domains:
     IPR001841 Znf_RING
     IPR004087 KH_dom
     IPR013083 Znf_RING/FYVE/PHD
     IPR004088 KH_dom_type_1

    Graphical View of Domain Structure for InterPro Entry Q6ZN04

    ProtoNet protein and cluster: Q6ZN04

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: MEX3B_HUMAN, Q6ZN04
    Domain: Binds RNA through its KH domains
    Similarity: Contains 2 KH domains
    Similarity: Contains 1 RING-type zinc finger


    MEX3B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MEX3B_HUMAN, Q6ZN04
    Function: RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0005509calcium ion binding ISS--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    MEX3B for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MEX3B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MEX3B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MEX3B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MEX3B

    miRNA
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    miRTarBase miRNAs that target MEX3B:
    hsa-mir-92b-3p (MIRT040581), hsa-mir-215-5p (MIRT024256), hsa-mir-192-5p (MIRT026856)

    Block miRNA regulation of human, mouse, rat MEX3B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MEX3B (see all 76):
    hsa-miR-607 hsa-miR-300 hsa-miR-374a hsa-miR-30d hsa-miR-1273d hsa-miR-30a hsa-miR-3613-3p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidMEX3B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MEX3B

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: MEX3B (NM_032246)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEX3B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEX3B

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MEX3B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEX3B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MEX3B_HUMAN, Q6ZN04: Nucleus. Cytoplasm. Cytoplasm, P-body. Cytoplasmic granule. Note=Predominantly expressed in
    the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. Localization to
    P-bodies is dependent on 14-3-3
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    MEX3B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MEX3B
    Interactions:

        Search GeneGlobe Interaction Network for MEX3B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for MEX3B (Q6ZN042, 3 ENSP000003299184) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2D3P610772, 3, ENSP000003497224MINT-64939 MINT-8276108 I2D: score=5 STRING: ENSP00000349722
    SNUPNO951492, 3, ENSP000003098314MINT-8271883 I2D: score=2 STRING: ENSP00000309831
    NUDT3O959892, 3MINT-8264852 I2D: score=2 
    RAP1GAPP477363, ENSP000003638974I2D: score=4 STRING: ENSP00000363897
    SMAD4Q134853, ENSP000003415514I2D: score=3 STRING: ENSP00000341551
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ISS--
    GO:0046777protein autophosphorylation ISS--

    MEX3B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MEX3B



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MEX3B gene: 
    NM_032246.4  

    Unigene Cluster for MEX3B:

    Mex-3 homolog B (C. elegans)
    Hs.104744  [show with all ESTs]
    Unigene Representative Sequence: NM_032246
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000329713(uc002bgq.1) ENST00000558133
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MEX3B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MEX3B (see all 76):
    hsa-miR-607 hsa-miR-300 hsa-miR-374a hsa-miR-30d hsa-miR-1273d hsa-miR-30a hsa-miR-3613-3p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidMEX3B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MEX3B
    Predesigned siRNA for gene silencing in human, mouse, rat MEX3B
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MEX3B (NM_032246)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEX3B
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MEX3B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MEX3B
      QuantiTect SYBR Green Assays in human, mouse, rat MEX3B
      QuantiFast Probe-based Assays in human, mouse, rat MEX3B

    Additional mRNA sequence: 

    AK094145.1 AK094633.1 AK131424.1 AL136778.1 AY950678.1 BC036211.1 BC111545.1 

    3 DOTS entries:

    DT.97773326  DT.97769376  DT.100656810 

    Selected AceView cDNA sequences (see all 50):

    BM698334 AB095929 AK131424 CR605617 AA813239 AI039472 CA449423 NM_032246 
    AK094633 BM667045 AA405662 BU501483 AI218507 AA598858 AA405110 AI208848 
    BF979865 AK094145 AL136778 BX107789 AI218506 AI885956 BG503360 AA770412 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MEX3B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCAAATACT
    MEX3B Expression
    About this image


    MEX3B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Testis (Reproductive System)
    MEX3B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MEX3B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.104744

    UniProtKB/Swiss-Prot: MEX3B_HUMAN, Q6ZN04
    Tissue specificity: Highest levels found in fetal brain and testis. Detected in the adult intestinal epithelium,
    specifically in goblet cell at protein level

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEX3B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MEX3B gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mex3b1 , 5 mex3 homolog B (C. elegans)1, 5 88.85(n)1
    97.89(a)1
      7 (47.35 cM)5
    1087971  NM_175366.31  NP_780575.21 
     828673335 
    lizard
    (Anolis carolinensis)
    Reptilia MEX3B6
    mex-3 RNA binding family member B
    69(a)
    1 ↔ 1
    GL343894.1(4724-6148)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX844837.12   -- 82.48(n)    BX844837.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mex3b1 mex-3 homolog B (C. elegans) 73.06(n)
    79.46(a)
      569582  NM_001080993.1  NP_001074462.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG113606
    --
    32(a)
    1 → many
    4(691768-711276)
    worm
    (Caenorhabditis elegans)
    Secernentea mex-36
    Protein MEX-3, isoform b
    35(a)
    1 → many
    I(127297-134065) WBGene00003229


    ENSEMBL Gene Tree for MEX3B (if available)
    TreeFam Gene Tree for MEX3B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MEX3B gene
    MEX3A2  MEX3C2  MEX3D2  
    3 SIMAP similar genes for MEX3B using alignment to 1 protein entry:     MEX3B_HUMAN:
    RKHD1    MEX3D    MEX3C

    MEX3B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MEX3B (see all 151)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs585183301,2
    C,F--59092216(+) TATGTT/CAATTT 1 -- ds50012Minor allele frequency- C:0.10WA 120
    rs1125492011,2
    F--59092344(+) CAATTC/TTTAGA 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs1161234881,2
    F--59092399(+) CTGGCC/TTGTTT 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1422045731,2
    --59092452(+) ATTCCA/GTATTT 1 -- ds50010--------
    rs9579421,2
    C,F,A,H--59092460(-) ACAAGC/TTGAAA 1 -- ds500133Minor allele frequency- N:0.00EA NA NS WA CSA 3346
    rs1913171711,2
    --59092642(+) TAAAAC/TTCTTG 1 -- ut310--------
    rs1828647611,2
    --59092847(+) TAGAGG/TGGTGC 1 -- ut310--------
    rs1463650501,2
    --59092987(+) GAATAC/GAAAAT 1 -- ut310--------
    rs1396632411,2
    C--59093241(+) ATTTTA/TCAAGT 1 -- ut310--------
    rs1424715811,2
    C--59093421(+) ACTGTA/GTTCTA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MEX3B (82334119 - 82338482 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MEX3B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422504CNV Duplication17116639
    nsv827415CNV Gain20364138
    nsv833067CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MEX3B
    DNA2.0 Custom Variant and Variant Library Synthesis for MEX3B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611008    OMIM disorders: --

    3 diseases for MEX3B:    
    About MalaCards
    cerebellar ataxia    ataxia    neuronitis


    MEX3B for disorders           About GeneDecksing

    Genetic Association Database (GAD): MEX3B

    Export disorders for MEX3B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MEX3B gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with MEX3B)
        Utopia: connect your pdf to the dynamic
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    1. Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. (PubMed id 17267406)1, 2, 3 Buchet-Poyau K.... Billaud M. (Nucleic Acids Res. 2007)
    2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    3. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. (PubMed id 19079261)1, 4 Willer C.J....Hirschhorn J.N. (Nat. Genet. 2009)
    4. Interaction with 14-3-3 adaptors regulates the sorting of hMex-3B RNA-binding protein to distinct classes of RNA granules. (PubMed id 18779327)1, 2 Courchet J.... Billaud M. (J. Biol. Chem. 2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Identification of novel ATP13A2 interactors and their role in I+-synuclein misfolding and toxicity. (PubMed id 22645275)1 Usenovic M....Krainc D. (Hum. Mol. Genet. 2012)
    9. A whole genome screen for HIV restriction factors. (PubMed id 22082156)1 Liu L....McKnight A. (Retrovirology 2011)
    10. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84206 HGNC: 25297 AceView: RKHD3 Ensembl:ENSG00000183496 euGenes: HUgn84206
    ECgene: MEX3B H-InvDB: MEX3B

    (According to HUGE)
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    HUGE: KIAA2009

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MEX3B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MEX3B gene:
    Search GeneIP for patents involving MEX3B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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