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Aliases for MEX3A Gene

Aliases for MEX3A Gene

  • Mex-3 RNA Binding Family Member A 2 3
  • RING Finger And KH Domain-Containing Protein 4 3 4
  • Ring Finger And KH Domain Containing 4 2 3
  • RKHD4 3 4
  • Ring Finger And KH Domain Containing Protein 3
  • Mex-3 Homolog A (C. Elegans) 2
  • MEX-3A 3

External Ids for MEX3A Gene

Previous HGNC Symbols for MEX3A Gene

  • RKHD4

Previous GeneCards Identifiers for MEX3A Gene

  • GC01M154310
  • GC01M127404

Summaries for MEX3A Gene

GeneCards Summary for MEX3A Gene

MEX3A (Mex-3 RNA Binding Family Member A) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is MEX3D.

UniProtKB/Swiss-Prot for MEX3A Gene

  • RNA binding protein, may be involved in post-transcriptional regulatory mechanisms

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEX3A Gene

Genomics for MEX3A Gene

Regulatory Elements for MEX3A Gene

Genomic Location for MEX3A Gene

Chromosome:
1
Start:
156,072,013 bp from pter
End:
156,081,998 bp from pter
Size:
9,986 bases
Orientation:
Minus strand

Genomic View for MEX3A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MEX3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEX3A Gene

Proteins for MEX3A Gene

  • Protein details for MEX3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1L020-MEX3A_HUMAN
    Recommended name:
    RNA-binding protein MEX3A
    Protein Accession:
    A1L020

    Protein attributes for MEX3A Gene

    Size:
    520 amino acids
    Molecular mass:
    54173 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MEX3A Gene

Proteomics data for MEX3A Gene at MOPED

Post-translational modifications for MEX3A Gene

Other Protein References for MEX3A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MEX3A Gene

Domains & Families for MEX3A Gene

Gene Families for MEX3A Gene

Protein Domains for MEX3A Gene

Suggested Antigen Peptide Sequences for MEX3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A1L020

UniProtKB/Swiss-Prot:

MEX3A_HUMAN :
  • Binds RNA through its KH domains.
  • Contains 1 RING-type zinc finger.
Domain:
  • Binds RNA through its KH domains.
  • Contains 2 KH domains.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with MEX3A: view

Function for MEX3A Gene

Molecular function for MEX3A Gene

UniProtKB/Swiss-Prot Function:
RNA binding protein, may be involved in post-transcriptional regulatory mechanisms

Gene Ontology (GO) - Molecular Function for MEX3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with MEX3A: view

Phenotypes for MEX3A Gene

GenomeRNAi human phenotypes for MEX3A:
genes like me logo Genes that share phenotypes with MEX3A: view

Animal Model Products

miRNA for MEX3A Gene

miRTarBase miRNAs that target MEX3A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MEX3A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MEX3A Gene

Localization for MEX3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEX3A Gene

Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MEX3A Gene COMPARTMENTS Subcellular localization image for MEX3A gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for MEX3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with MEX3A: view

Pathways & Interactions for MEX3A Gene

SuperPathways for MEX3A Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for MEX3A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000432845%0d%0a9606.ENSP00000313007%0d%0a
Selected Interacting proteins: ENSP00000432845 for MEX3A Gene via STRING

Symbol External ID(s) Details
PABPC1

Gene Ontology (GO) - Biological Process for MEX3A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MEX3A Gene

Drugs & Compounds for MEX3A Gene

No Compound Related Data Available

Transcripts for MEX3A Gene

mRNA/cDNA for MEX3A Gene

Unigene Clusters for MEX3A Gene

Mex-3 homolog A (C. elegans):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MEX3A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEX3A Gene

No ASD Table

Relevant External Links for MEX3A Gene

GeneLoc Exon Structure for
MEX3A
ECgene alternative splicing isoforms for
MEX3A

Expression for MEX3A Gene

mRNA expression in normal human tissues for MEX3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEX3A Gene

This gene is overexpressed in Ovary (x5.8).

Protein differential expression in normal tissues from HIPED for MEX3A Gene

This gene is overexpressed in Colon (18.0), Testis (14.3), and Gallbladder (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for MEX3A Gene



SOURCE GeneReport for Unigene cluster for MEX3A Gene Hs.591496

mRNA Expression by UniProt/SwissProt for MEX3A Gene

A1L020-MEX3A_HUMAN
Tissue specificity: Highest levels found in fetal brain and testis. Detected also in thymus, salivary gland and uterus.
genes like me logo Genes that share expression patterns with MEX3A: view

Protein tissue co-expression partners for MEX3A Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for MEX3A Gene

This gene was present in the common ancestor of animals.

Orthologs for MEX3A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MEX3A 35
  • 94.29 (n)
  • 98.65 (a)
MEX3A 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mex3a 35
  • 90.56 (n)
  • 97.11 (a)
Mex3a 16
Mex3a 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MEX3A 35
  • 99.87 (n)
  • 100 (a)
MEX3A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mex3a 35
  • 88.35 (n)
  • 97.55 (a)
dog
(Canis familiaris)
Mammalia MEX3A 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MEX3A 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves MEX3A 35
  • 74.64 (n)
  • 77.89 (a)
MEX3A 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MEX3A 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mex3a 35
  • 70.66 (n)
  • 76.57 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100332760 35
  • 60.16 (n)
  • 59.24 (a)
CABZ01027547.1 36
  • 46 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11360 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mex-3 36
  • 34 (a)
OneToMany
Species with no ortholog for MEX3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MEX3A Gene

ENSEMBL:
Gene Tree for MEX3A (if available)
TreeFam:
Gene Tree for MEX3A (if available)

Paralogs for MEX3A Gene

Paralogs for MEX3A Gene

(3) SIMAP similar genes for MEX3A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MEX3A: view

Variants for MEX3A Gene

Sequence variations from dbSNP and Humsavar for MEX3A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1055801 -- 156,073,731(-) AAAAA(A/C)AAGAG utr-variant-3-prime
rs1055803 -- 156,073,728(-) AACAA(A/G)AGAGA utr-variant-3-prime
rs1055804 -- 156,073,726(-) caaga(A/G)agaaa utr-variant-3-prime
rs1055805 -- 156,073,724(-) agaga(A/G)aaaga utr-variant-3-prime
rs1138046 -- 156,079,419(-) ggcca(A/G)catag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MEX3A Gene

Variant ID Type Subtype PubMed ID
nsv509513 CNV Insertion 20534489
dgv79n67 CNV Gain 20364138
nsv824831 CNV Gain 20364138

Variation tolerance for MEX3A Gene

Residual Variation Intolerance Score: 17.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MEX3A Gene

HapMap Linkage Disequilibrium report
MEX3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEX3A Gene

Disorders for MEX3A Gene

Relevant External Links for MEX3A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MEX3A
genes like me logo Genes that share disorders with MEX3A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEX3A Gene

Publications for MEX3A Gene

  1. Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. (PMID: 17267406) Buchet-Poyau K. … Billaud M. (Nucleic Acids Res. 2007) 2 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. (PMID: 22681889) Baltz A.G. … Landthaler M. (Mol. Cell 2012) 67
  4. Interaction with 14-3-3 adaptors regulates the sorting of hMex-3B RNA-binding protein to distinct classes of RNA granules. (PMID: 18779327) Courchet J. … Billaud M. (J. Biol. Chem. 2008) 67
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for MEX3A Gene

Sources for MEX3A Gene

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