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Aliases for MEX3A Gene

Aliases for MEX3A Gene

  • Mex-3 RNA Binding Family Member A 2 3 5
  • RING Finger And KH Domain-Containing Protein 4 3 4
  • Ring Finger And KH Domain Containing 4 2 3
  • RKHD4 3 4
  • Ring Finger And KH Domain Containing Protein 3
  • Mex-3 Homolog A (C. Elegans) 2
  • RNA-Binding Protein MEX3A 3
  • MEX-3A 3

External Ids for MEX3A Gene

Previous HGNC Symbols for MEX3A Gene

  • RKHD4

Previous GeneCards Identifiers for MEX3A Gene

  • GC01M154310
  • GC01M127404

Summaries for MEX3A Gene

GeneCards Summary for MEX3A Gene

MEX3A (Mex-3 RNA Binding Family Member A) is a Protein Coding gene. Diseases associated with MEX3A include Wilson-Turner Syndrome. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is MEX3B.

UniProtKB/Swiss-Prot for MEX3A Gene

  • RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.

Additional gene information for MEX3A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEX3A Gene

Genomics for MEX3A Gene

Regulatory Elements for MEX3A Gene

Enhancers for MEX3A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H156099 2.5 VISTA FANTOM5 Ensembl ENCODE dbSUPER 22.9 -22.2 -22168 8 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 FOS SP3 LMNA KIAA0907 MEX3A ENSG00000271267 LAMTOR2 UBQLN4 BGLAP RXFP4 MSTO1 MSTO2P
GH01H156111 1.8 FANTOM5 ENCODE dbSUPER 13.1 -39.4 -39392 19 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 GON4L CLK2 RRNAD1 KIAA0907 LOC246784 LMNA MSTO1 MSTO2P PRCC ISG20L2
GH01H156145 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.8 -67.4 -67356 7 HDGF PKNOX1 ARNT SIN3A ARID4B FEZF1 DMAP1 ZNF2 YY1 SLC30A9 SLC25A44 ENSG00000252236 LMNA MEX3A BGLAP PAQR6 TSACC CCT3 SMG5 ARHGEF2
GH01H155937 2 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +138.8 138779 10 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B FEZF1 DMAP1 SLC30A9 ZNF143 GON4L CLK2 RIT1 KIAA0907 RRNAD1 ENSG00000271267 YY1AP1 ARHGEF2 RUSC1-AS1 FLAD1
GH01H156000 1.4 Ensembl ENCODE dbSUPER 11.3 +79.5 79520 3 ELF3 TBP FOXA2 ZSCAN4 ARID4B ZSCAN9 RAD21 RFX5 ZNF121 ZNF366 RIT1 RXFP4 KIAA0907 LAMTOR2 UBQLN4 SCARNA4 MEX3A LMNA SNORA80E GLMP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MEX3A on UCSC Golden Path with GeneCards custom track

Promoters for MEX3A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000014141 -2 3601 PKNOX1 ATF1 ZNF133 ARID4B SIN3A ETS1 ZNF121 GLIS2 ZNF143 ATF7

Genomic Location for MEX3A Gene

Chromosome:
1
Start:
156,072,013 bp from pter
End:
156,081,998 bp from pter
Size:
9,986 bases
Orientation:
Minus strand

Genomic View for MEX3A Gene

Genes around MEX3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEX3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEX3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEX3A Gene

Proteins for MEX3A Gene

  • Protein details for MEX3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1L020-MEX3A_HUMAN
    Recommended name:
    RNA-binding protein MEX3A
    Protein Accession:
    A1L020

    Protein attributes for MEX3A Gene

    Size:
    520 amino acids
    Molecular mass:
    54173 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MEX3A Gene

Post-translational modifications for MEX3A Gene

Other Protein References for MEX3A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MEX3A Gene

Domains & Families for MEX3A Gene

Gene Families for MEX3A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MEX3A Gene

Suggested Antigen Peptide Sequences for MEX3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A1L020

UniProtKB/Swiss-Prot:

MEX3A_HUMAN :
  • Binds RNA through its KH domains.
Domain:
  • Binds RNA through its KH domains.
genes like me logo Genes that share domains with MEX3A: view

Function for MEX3A Gene

Molecular function for MEX3A Gene

UniProtKB/Swiss-Prot Function:
RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.

Phenotypes From GWAS Catalog for MEX3A Gene

Gene Ontology (GO) - Molecular Function for MEX3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA 22681889
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MEX3A: view

Phenotypes for MEX3A Gene

genes like me logo Genes that share phenotypes with MEX3A: view

Animal Model Products

CRISPR Products

miRNA for MEX3A Gene

miRTarBase miRNAs that target MEX3A

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MEX3A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MEX3A Gene

Localization for MEX3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEX3A Gene

Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEX3A gene
Compartment Confidence
cytosol 4
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MEX3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with MEX3A: view

Pathways & Interactions for MEX3A Gene

SuperPathways for MEX3A Gene

No Data Available

Interacting Proteins for MEX3A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000432845%0d%0a9606.ENSP00000313007%0d%0a
Selected Interacting proteins: ENSP00000432845 A1L020-MEX3A_HUMAN for MEX3A Gene via STRING IID

Gene Ontology (GO) - Biological Process for MEX3A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MEX3A Gene

Drugs & Compounds for MEX3A Gene

No Compound Related Data Available

Transcripts for MEX3A Gene

mRNA/cDNA for MEX3A Gene

Unigene Clusters for MEX3A Gene

Mex-3 homolog A (C. elegans):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MEX3A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MEX3A Gene

No ASD Table

Relevant External Links for MEX3A Gene

GeneLoc Exon Structure for
MEX3A
ECgene alternative splicing isoforms for
MEX3A

Expression for MEX3A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MEX3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEX3A Gene

This gene is overexpressed in Ovary (x5.8).

Protein differential expression in normal tissues from HIPED for MEX3A Gene

This gene is overexpressed in Colon (18.0), Testis (14.3), and Gallbladder (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MEX3A Gene



Protein tissue co-expression partners for MEX3A Gene

NURSA nuclear receptor signaling pathways regulating expression of MEX3A Gene:

MEX3A

SOURCE GeneReport for Unigene cluster for MEX3A Gene:

Hs.591496

mRNA Expression by UniProt/SwissProt for MEX3A Gene:

A1L020-MEX3A_HUMAN
Tissue specificity: Highest levels found in fetal brain and testis. Detected also in thymus, salivary gland and uterus.
genes like me logo Genes that share expression patterns with MEX3A: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MEX3A Gene

Orthologs for MEX3A Gene

This gene was present in the common ancestor of animals.

Orthologs for MEX3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEX3A 33 34
  • 99.87 (n)
cow
(Bos Taurus)
Mammalia MEX3A 33 34
  • 94.29 (n)
dog
(Canis familiaris)
Mammalia MEX3A 34
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mex3a 33 16 34
  • 90.56 (n)
oppossum
(Monodelphis domestica)
Mammalia MEX3A 34
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mex3a 33
  • 88.35 (n)
chicken
(Gallus gallus)
Aves MEX3A 33 34
  • 74.64 (n)
lizard
(Anolis carolinensis)
Reptilia MEX3A 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mex3a 33
  • 70.66 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100332760 33
  • 60.16 (n)
CABZ01027547.1 34
  • 46 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11360 34
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mex-3 34
  • 34 (a)
OneToMany
Species where no ortholog for MEX3A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MEX3A Gene

ENSEMBL:
Gene Tree for MEX3A (if available)
TreeFam:
Gene Tree for MEX3A (if available)

Paralogs for MEX3A Gene

Paralogs for MEX3A Gene

(3) SIMAP similar genes for MEX3A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MEX3A: view

Variants for MEX3A Gene

Sequence variations from dbSNP and Humsavar for MEX3A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000052361 -- 156,073,741(+) TGGTT(-/A)AAAAA utr-variant-3-prime
rs1000109884 -- 156,081,652(+) GAGCG(C/T)AGAGC upstream-variant-2KB, reference, missense
rs1000134001 -- 156,078,422(+) CAACC(C/G)CGTGT intron-variant
rs1000222586 -- 156,074,026(+) GACCG(A/G)GTTCC utr-variant-3-prime
rs1000296361 -- 156,073,772(+) TCACA(C/T)ATCTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MEX3A Gene

Variant ID Type Subtype PubMed ID
dgv79n67 CNV gain 20364138
nsv1078975 CNV deletion 25765185
nsv1130977 CNV deletion 24896259
nsv509513 CNV insertion 20534489
nsv824831 CNV gain 20364138

Variation tolerance for MEX3A Gene

Residual Variation Intolerance Score: 17.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MEX3A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEX3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEX3A Gene

Disorders for MEX3A Gene

MalaCards: The human disease database

(1) MalaCards diseases for MEX3A Gene - From: DISEASES

Disorder Aliases PubMed IDs
wilson-turner syndrome
  • mental retardation, x-linked, syndromic 6
- elite association - COSMIC cancer census association via MalaCards
Search MEX3A in MalaCards View complete list of genes associated with diseases

Relevant External Links for MEX3A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MEX3A
genes like me logo Genes that share disorders with MEX3A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MEX3A Gene

Publications for MEX3A Gene

  1. Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. (PMID: 17267406) Buchet-Poyau K … Billaud M (Nucleic acids research 2007) 2 3 4 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal KB … Olsen JV (Science signaling 2015) 3 60
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 60
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. (PMID: 22681889) Baltz AG … Landthaler M (Molecular cell 2012) 3 60

Products for MEX3A Gene

Sources for MEX3A Gene

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