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Aliases for MEX3A Gene

Aliases for MEX3A Gene

  • Mex-3 RNA Binding Family Member A 2 3 5
  • RING Finger And KH Domain-Containing Protein 4 3 4
  • Ring Finger And KH Domain Containing 4 2 3
  • RKHD4 3 4
  • Ring Finger And KH Domain Containing Protein 3
  • Mex-3 Homolog A (C. Elegans) 2
  • RNA-Binding Protein MEX3A 3
  • MEX-3A 3

External Ids for MEX3A Gene

Previous HGNC Symbols for MEX3A Gene

  • RKHD4

Previous GeneCards Identifiers for MEX3A Gene

  • GC01M154310
  • GC01M127404

Summaries for MEX3A Gene

GeneCards Summary for MEX3A Gene

MEX3A (Mex-3 RNA Binding Family Member A) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is MEX3B.

UniProtKB/Swiss-Prot for MEX3A Gene

  • RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEX3A Gene

Genomics for MEX3A Gene

Regulatory Elements for MEX3A Gene

Enhancers for MEX3A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F156099 2 VISTA FANTOM5 ENCODE 22.9 -22.2 -22168 8.4 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 FOS LMNA MEX3A LAMTOR2 UBQLN4 KIAA0907 RXFP4 FAM189B RIT1 YY1AP1 MEF2D
GH01F156111 1.6 FANTOM5 ENCODE 13.1 -39.4 -39392 19.4 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 KIAA0907 MSTO2P ENSG00000271267 RRNAD1 LMNA ASH1L LOC246784 PEAR1 MEX3A DPM3
GH01F155937 1.8 FANTOM5 Ensembl ENCODE 10.4 +138.8 138779 10.9 HDGF PKNOX1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 LOC101928120 RIT1 KIAA0907 ASH1L ARHGEF2 LOC107985210 SNORA80E UBQLN4 LAMTOR2 MSTO2P
GH01F156145 1.5 FANTOM5 ENCODE 11.8 -67.4 -67356 7.7 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC25A44 ENSG00000252236 LMNA MEX3A BGLAP PAQR6 TSACC CCT3 SMG5 ARHGEF2
GH01F156000 1.3 Ensembl ENCODE 11.3 +79.5 79520 3.6 HDGF CREB3L1 ARID4B SIN3A ZNF121 ZNF207 FOS KDM4B ZNF263 JUNB RIT1 RXFP4 KIAA0907 UBQLN4 LAMTOR2 SCARNA4 MEX3A LMNA SNORA80E GLMP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MEX3A on UCSC Golden Path with GeneCards custom track

Promoters for MEX3A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000545676 -2 4001 PKNOX1 ARNT CREB3L1 ARID4B SIN3A ZNF143 KLF13 ZNF263 SP3 SP5

Genomic Location for MEX3A Gene

Chromosome:
1
Start:
156,072,013 bp from pter
End:
156,081,998 bp from pter
Size:
9,986 bases
Orientation:
Minus strand

Genomic View for MEX3A Gene

Genes around MEX3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEX3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEX3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEX3A Gene

Proteins for MEX3A Gene

  • Protein details for MEX3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1L020-MEX3A_HUMAN
    Recommended name:
    RNA-binding protein MEX3A
    Protein Accession:
    A1L020

    Protein attributes for MEX3A Gene

    Size:
    520 amino acids
    Molecular mass:
    54173 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MEX3A Gene

Post-translational modifications for MEX3A Gene

Other Protein References for MEX3A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MEX3A Gene

Domains & Families for MEX3A Gene

Gene Families for MEX3A Gene

Protein Domains for MEX3A Gene

Suggested Antigen Peptide Sequences for MEX3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A1L020

UniProtKB/Swiss-Prot:

MEX3A_HUMAN :
  • Binds RNA through its KH domains.
  • Contains 1 RING-type zinc finger.
Domain:
  • Binds RNA through its KH domains.
  • Contains 2 KH domains.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with MEX3A: view

Function for MEX3A Gene

Molecular function for MEX3A Gene

UniProtKB/Swiss-Prot Function:
RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.

Gene Ontology (GO) - Molecular Function for MEX3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MEX3A: view

Phenotypes for MEX3A Gene

genes like me logo Genes that share phenotypes with MEX3A: view

Animal Model Products

miRNA for MEX3A Gene

miRTarBase miRNAs that target MEX3A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MEX3A Gene

Localization for MEX3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEX3A Gene

Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEX3A gene
Compartment Confidence
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for MEX3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MEX3A: view

Pathways & Interactions for MEX3A Gene

SuperPathways for MEX3A Gene

No Data Available

Interacting Proteins for MEX3A Gene

Gene Ontology (GO) - Biological Process for MEX3A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MEX3A Gene

Transcripts for MEX3A Gene

mRNA/cDNA for MEX3A Gene

Unigene Clusters for MEX3A Gene

Mex-3 homolog A (C. elegans):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEX3A Gene

No ASD Table

Relevant External Links for MEX3A Gene

GeneLoc Exon Structure for
MEX3A
ECgene alternative splicing isoforms for
MEX3A

Expression for MEX3A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MEX3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEX3A Gene

This gene is overexpressed in Ovary (x5.8).

Protein differential expression in normal tissues from HIPED for MEX3A Gene

This gene is overexpressed in Colon (18.0), Testis (14.3), and Gallbladder (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MEX3A Gene



Protein tissue co-expression partners for MEX3A Gene

NURSA nuclear receptor signaling pathways regulating expression of MEX3A Gene:

MEX3A

SOURCE GeneReport for Unigene cluster for MEX3A Gene:

Hs.591496

mRNA Expression by UniProt/SwissProt for MEX3A Gene:

A1L020-MEX3A_HUMAN
Tissue specificity: Highest levels found in fetal brain and testis. Detected also in thymus, salivary gland and uterus.
genes like me logo Genes that share expression patterns with MEX3A: view

Primer Products

Orthologs for MEX3A Gene

This gene was present in the common ancestor of animals.

Orthologs for MEX3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEX3A 34 35
  • 99.87 (n)
cow
(Bos Taurus)
Mammalia MEX3A 34 35
  • 94.29 (n)
dog
(Canis familiaris)
Mammalia MEX3A 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mex3a 34 16 35
  • 90.56 (n)
oppossum
(Monodelphis domestica)
Mammalia MEX3A 35
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mex3a 34
  • 88.35 (n)
chicken
(Gallus gallus)
Aves MEX3A 34 35
  • 74.64 (n)
lizard
(Anolis carolinensis)
Reptilia MEX3A 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mex3a 34
  • 70.66 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100332760 34
  • 60.16 (n)
CABZ01027547.1 35
  • 46 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11360 35
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mex-3 35
  • 34 (a)
OneToMany
Species where no ortholog for MEX3A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MEX3A Gene

ENSEMBL:
Gene Tree for MEX3A (if available)
TreeFam:
Gene Tree for MEX3A (if available)

Paralogs for MEX3A Gene

Paralogs for MEX3A Gene

(3) SIMAP similar genes for MEX3A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MEX3A: view

Variants for MEX3A Gene

Sequence variations from dbSNP and Humsavar for MEX3A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10047112 -- 156,075,871(+) ACTGC(A/G)GGGGA utr-variant-3-prime
rs1055801 -- 156,073,731(-) AAAAA(A/C)AAGAG utr-variant-3-prime
rs1055803 -- 156,073,728(-) AACAA(A/G)AGAGA utr-variant-3-prime
rs1055804 -- 156,073,726(-) caaga(A/G)agaaa utr-variant-3-prime
rs1055805 -- 156,073,724(-) agaga(A/G)aaaga utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MEX3A Gene

Variant ID Type Subtype PubMed ID
nsv824831 CNV gain 20364138
nsv509513 CNV insertion 20534489
nsv1130977 CNV deletion 24896259
nsv1078975 CNV deletion 25765185
dgv79n67 CNV gain 20364138

Variation tolerance for MEX3A Gene

Residual Variation Intolerance Score: 17.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MEX3A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEX3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEX3A Gene

Disorders for MEX3A Gene

Relevant External Links for MEX3A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MEX3A

No disorders were found for MEX3A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEX3A Gene

Publications for MEX3A Gene

  1. Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. (PMID: 17267406) Buchet-Poyau K. … Billaud M. (Nucleic Acids Res. 2007) 2 3 4 64
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64
  3. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. (PMID: 22681889) Baltz A.G. … Landthaler M. (Mol. Cell 2012) 3 64
  5. Interaction with 14-3-3 adaptors regulates the sorting of hMex-3B RNA-binding protein to distinct classes of RNA granules. (PMID: 18779327) Courchet J. … Billaud M. (J. Biol. Chem. 2008) 3 64

Products for MEX3A Gene

Sources for MEX3A Gene

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