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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MEX3A Gene

protein-coding GIFtS: 38
GCID: GC01M156041

mex-3 homolog A (C. elegans)

(Previous name: ring finger and KH domain containing 4 )
(Previous symbol: RKHD4)

Search for MEX3A
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Mex-3 Homolog A (C. Elegans)¹ ²		MEX-3A²
RKHD4¹ ² ³		Ring Finger And KH Domain Containing Protein²
Ring Finger And KH Domain Containing 4¹ ²		RNA-Binding Protein MEX3A²
RING Finger And KH Domain-Containing Protein 4² ³

External Ids:	HGNC: 33482¹	Entrez Gene: 92312²	Ensembl: ENSG00000254726⁷	OMIM: 611007⁵	UniProtKB: A1L020³

Export aliases for MEX3A gene to outside databases

Previous GC identifers: GC01M154310 GC01M127404

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MEX3A_HUMAN, A1L020

Function: RNA binding protein, may be involved in post-transcriptional regulatory mechanisms

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MEX3A gene promoter:
p53 Nkx2-5 E4BP4 CREB Pax-3 SRY Sox9 SEF-1 (1) Pax-4a MRF-2
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for MEX3A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEX3A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22 Ensembl cytogenetic band: 1q22 HGNC cytogenetic band: 1q22

MEX3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEX3A gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M156041: view genomic region (about GC identifiers)

Start:	156,041,804 bp from pter	End:	156,051,789 bp from pter
Size:	9,986 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MEX3A_HUMAN, A1L020 (See protein sequence)

Recommended Name: RNA-binding protein MEX3A

Size: 520 amino acids; 54173 Da

Subcellular location: Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Predominantly expressed in the cytoplasm and shuttles

between the cytoplasm and the nucleus through the CRM1 export pathway

Explore the universe of human proteins at neXtProt for MEX3A: NX_A1L020

Post-translational modifications:

Phosphorylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_A1L020

MEX3A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001087194.1

ENSEMBL proteins:

ENSP00000432845

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	Uscn Proteins for MEX3A

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000932	cytoplasmic mRNA processing body	IEA	--
GO:0005634	nucleus	IEA	--

MEX3A for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MEX3A for domains About GeneDecksing

4 InterPro domains/families:

IPR001841 Znf_RING

IPR004087 KH_dom

IPR013083 Znf_RING/FYVE/PHD

IPR004088 KH_dom_type_1

Graphical View of Domain Structure for InterPro Entry A1L020

ProtoNet protein and cluster: A1L020

UniProtKB/Swiss-Prot: MEX3A_HUMAN, A1L020

Domain: Binds RNA through its KH domains (By similarity)

Similarity: Contains 2 KH domains

Similarity: Contains 1 RING-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MEX3A_HUMAN, A1L020

Function: RNA binding protein, may be involved in post-transcriptional regulatory mechanisms

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In Situ Assay
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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

MEX3A for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for MEX3A:

Decreased influenza A/WSN/33 r

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MEX3A

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MEX3A
Search CenterWatch for drugs/clinical trials and news about MEX3A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for MEX3A gene:

NM_001093725.1

Unigene Cluster for MEX3A:

Mex-3 homolog A (C. elegans)

Hs.591496 [show with all ESTs]

Unigene Representative Sequence: NM_001093725

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000532414(uc001fnd.4) ENST00000442784

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Additional cDNA sequence:

AK024097.1 AK095491.1 AK125482.1 AY950677.1 BC033283.2

4 DOTS entries:

DT.100747821 DT.108210 DT.100747820 DT.100800740

24/66 AceView cDNA sequences (see all 66):

BU739319 AK125482 AI870677 AI246430 BM725664 BM714959 BM676663 BM676798

BM970210 AA970152 BM719943 BU683403 BC033283 BU736024 AI191039 AI971894

T06772 BG329073 BG394689 AA780175 AI369343 BM678273 BM451586 AA084598

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MEX3A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAGGGAGCG

About this image

MEX3A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Endothelial Cells

Blood Brain Barrier, Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MEX3A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MEX3A

SOURCE GeneReport for Unigene cluster: Hs.591496

UniProtKB/Swiss-Prot: MEX3A_HUMAN, A1L020

Tissue specificity: Highest levels found in fetal brain and testis. Detected also in thymus, salivary gland and uterus

SABiosciences Expression via Pathway-Focused PCR Array including MEX3A:

Ubiquitin Ligases in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MEX3A gene from 5/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MEX3A¹	mex-3 homolog A (C. elegans)	76.99(n) 81.37(a)		426350 XM_424007.3 XP_424007.2
lizard (Anolis carolinensis)	Reptilia	MEX3A⁶	--	76(a)	1 ↔ 1	AAWZ02037012(2118-3260)
zebrafish (Danio rerio)	Actinopterygii	LOC100332760¹	RNA-binding protein MEX3B-like	60.04(n) 59.83(a)		100332760 XM_002665034.2 XP_002665080.1
fruit fly (Drosophila melanogaster)	Insecta	CG11360¹	CG11360	52.21(n) 54.74(a)		43810 NM_143677.3 NP_651934.2
worm (Caenorhabditis elegans)	Secernentea	mex-3⁶	Muscle EXcess family member (mex-3)	35(a)	possible ortholog	I(127297-134065)

ENSEMBL Gene Tree for MEX3A (if available)
TreeFam Gene Tree for MEX3A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MEX3A gene

MEX3B² MEX3C² MEX3D²

4 SIMAP similar genes for MEX3A using alignment to 1 protein entry: MEX3A_HUMAN:

RKHD1 MEX3C MEX3D MEX3B

MEX3A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs140231527^1,2		--	156041330(+)	`CTCCCA/GAGTAG`	1	--	ds500¹		0	--	--	--	--
rs181814775^1,2		--	156041349(+)	`ATAGGC/TATGTG`	1	--	ds500¹		0	--	--	--	--
rs145190305^1,2		--	156041445(+)	`AAGCGA/GTCCAT`	1	--	ds500¹		0	--	--	--	--
rs73004953^1,2	C,F,	--	156041533(+)	`AGGGTG/AGAACA`	1	--	ds500¹		2		WA CSA	4
rs79284691^1,2	F,	--	156041549(+)	`TGACTG/ACACCT`	1	--	ds500¹		4		CSA WA NA	242
rs149052281^1,2		--	156041564(+)	`AGAAGA/GGAAGG`	1	--	ds500¹		0	--	--	--	--
rs186220779^1,2		--	156041738(+)	`AATCCC/TCACCC`	1	--	ds500¹		0	--	--	--	--
rs114339050^1,2	C,F,	--	156041768(+)	`AAGATG/AGCACA`	1	--	ds500¹		1		WA	118
rs190538673^1,2		--	156041791(+)	`GAGAAC/TGAAGA`	1	--	ds500¹		0	--	--	--	--
rs182829057^1,2		--	156041939(+)	`TTCCCA/GCTTTT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MEX3A (156041804 - 156051789 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MEX3A: --

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MEX3A

DNA2.0 Custom Variant and Variant Library Synthesis for MEX3A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MEX3A for disorders About MalaCards

MEX3A for disorders About GeneDecksing

OMIM gene information: 611007 OMIM disorders: --

Export disorders for MEX3A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MEX3A gene integrated from 9 sources:
(articles sorted by number of sources associating them with MEX3A)

Utopia: connect your pdf to the dynamic
world of online information

Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. (PubMed id 17267406)^{1, 2, 3} Buchet-Poyau K.... Billaud M. (2007)
Interaction with 14-3-3 adaptors regulates the sorting of hMex-3B RNA-binding protein to distinct classes of RNA granules. (PubMed id 18779327)¹ Courchet J....Billaud M. (2008)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 92312	HGNC: 33482	AceView: LOC92312	Ensembl:ENSG00000254726	euGenes: HUgn92312
ECgene: MEX3A	H-InvDB: MEX3A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MEX3A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MEX3A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MEX3A gene:
Search GeneIP for patents involving MEX3A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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MEX3A Gene

mex-3 homolog A (C. elegans)

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MEX3A Gene

mex-3 homolog A (C. elegans)

Aliasesfor MEX3A gene

Summariesfor MEX3A gene

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Proteinsfor MEX3A gene

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Specialized Databases showing MEX3A gene

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for MEX3A gene

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for MEX3A gene

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for MEX3A gene

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for MEX3A gene

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