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Aliases for METTL9 Gene

Aliases for METTL9 Gene

  • Methyltransferase Like 9 2 3 5
  • DORA Reverse Strand Protein 1 2 3
  • DREV1 3 4
  • DREV 3 4
  • Methyltransferase-Like Protein 9 3
  • DORA Reverse Strand Protein 4
  • P53 Activated Protein 1 3
  • CTB-31N19.3 3
  • CGI-81 3
  • PAP1 3

External Ids for METTL9 Gene

Previous GeneCards Identifiers for METTL9 Gene

  • GC16P021519
  • GC16P019992

Summaries for METTL9 Gene

GeneCards Summary for METTL9 Gene

METTL9 (Methyltransferase Like 9) is a Protein Coding gene. Diseases associated with METTL9 include Inflammatory Bowel Disease 1. GO annotations related to this gene include methyltransferase activity.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL9 Gene

Genomics for METTL9 Gene

Regulatory Elements for METTL9 Gene

Enhancers for METTL9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G021624 1.8 FANTOM5 Ensembl ENCODE dbSUPER 27.8 +30.3 30304 6.3 HNRNPUL1 PKNOX1 FOXA2 SIN3A ARID4B DMAP1 ZNF48 SLC30A9 FOS SP5 METTL9 IGSF6 ENSG00000260905 ENSG00000260973 CRYM ENSG00000261596 GC16P021642
GH16G021597 1.8 FANTOM5 ENCODE dbSUPER 24.9 +2.3 2349 4.6 MLX CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D METTL9 IGSF6 NPIPB5 THUMPD1 CRYM LOC101927814 PIR54824
GH16G021644 1.8 FANTOM5 Ensembl ENCODE dbSUPER 22.6 +50.6 50592 7.6 HDGF FOXA2 PKNOX1 WRNIP1 YY1 TCF12 ZNF207 DEK JUNB REST METTL9 IGSF6 ENSG00000260905 CRYM GC16P021651 RNU6-196P
GH16G021607 1.8 FANTOM5 Ensembl ENCODE dbSUPER 18.2 +13.5 13483 5.8 ATF1 PKNOX1 ARNT TCF12 GATA2 NCOA1 MEF2D CREB3 MAFF SMARCA4 IGSF6 METTL9 ENSG00000261596 RNU6-1005P RNU6-196P CRYM ERI2 PIR54824
GH16G021631 0.8 ENCODE 24.2 +34.6 34609 1.6 TAL1 THRB RARA TCF12 ZNF776 FOXK2 NCOR1 IKZF2 GATAD2A HLF METTL9 NPIPB5 ENSG00000260306 MFSD13B ENSG00000260905 IGSF6 ERI2 ENSG00000261596 GC16P021642
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around METTL9 on UCSC Golden Path with GeneCards custom track

Genomic Location for METTL9 Gene

21,597,218 bp from pter
21,657,473 bp from pter
60,256 bases
Plus strand

Genomic View for METTL9 Gene

Genes around METTL9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL9 Gene

Proteins for METTL9 Gene

  • Protein details for METTL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Methyltransferase-like protein 9
    Protein Accession:
    Secondary Accessions:
    • Q8NBT8
    • Q9BWJ7
    • Q9H1A2
    • Q9Y390

    Protein attributes for METTL9 Gene

    318 amino acids
    Molecular mass:
    36536 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD34076.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for METTL9 Gene


neXtProt entry for METTL9 Gene

Post-translational modifications for METTL9 Gene

  • Ubiquitination at posLast=5151
  • Glycosylation at Asn35
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for METTL9 Gene

Domains & Families for METTL9 Gene

Gene Families for METTL9 Gene

Protein Domains for METTL9 Gene

Suggested Antigen Peptide Sequences for METTL9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DREV family.
  • Belongs to the DREV family.
genes like me logo Genes that share domains with METTL9: view

Function for METTL9 Gene

Gene Ontology (GO) - Molecular Function for METTL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21784977
genes like me logo Genes that share ontologies with METTL9: view
genes like me logo Genes that share phenotypes with METTL9: view

Animal Model Products

CRISPR Products

miRNA for METTL9 Gene

miRTarBase miRNAs that target METTL9

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL9 Gene

Localization for METTL9 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL9 gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2
extracellular 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for METTL9 Gene

Pathways & Interactions for METTL9 Gene

SuperPathways for METTL9 Gene

No Data Available

Interacting Proteins for METTL9 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: Q9H1A3-METL9_HUMAN ENSP00000350874 for METTL9 Gene via IID STRING

Gene Ontology (GO) - Biological Process for METTL9 Gene


No data available for Pathways by source and SIGNOR curated interactions for METTL9 Gene

Drugs & Compounds for METTL9 Gene

No Compound Related Data Available

Transcripts for METTL9 Gene

Unigene Clusters for METTL9 Gene

Methyltransferase like 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL9 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d
SP1: - - - - -
SP2: - - - - -
SP4: -
SP5: - - -
SP6: -
SP7: - -

Relevant External Links for METTL9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for METTL9 Gene

mRNA differential expression in normal tissues according to GTEx for METTL9 Gene

This gene is overexpressed in Whole Blood (x7.6).

Protein differential expression in normal tissues from HIPED for METTL9 Gene

This gene is overexpressed in Bone (33.0), Monocytes (17.5), and Platelet (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for METTL9 Gene

NURSA nuclear receptor signaling pathways regulating expression of METTL9 Gene:


SOURCE GeneReport for Unigene cluster for METTL9 Gene:


Evidence on tissue expression from TISSUES for METTL9 Gene

  • Nervous system(3.9)
  • Skin(3.6)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with METTL9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL9 Gene

Orthologs for METTL9 Gene

This gene was present in the common ancestor of animals.

Orthologs for METTL9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia METTL9 34 35
  • 99.68 (n)
(Bos Taurus)
Mammalia METTL9 34 35
  • 96.33 (n)
(Canis familiaris)
Mammalia METTL9 34 35
  • 96.23 (n)
(Mus musculus)
Mammalia Mettl9 34 16 35
  • 92.87 (n)
(Rattus norvegicus)
Mammalia Mettl9 34
  • 92.77 (n)
(Monodelphis domestica)
Mammalia METTL9 35
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia METTL9 35
  • 92 (a)
(Gallus gallus)
Aves METTL9 35 34
  • 83.07 (n)
(Anolis carolinensis)
Reptilia METTL9 35
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl9 34
  • 72.76 (n)
Str.3222 34
African clawed frog
(Xenopus laevis)
Amphibia MGC53836 34
(Danio rerio)
Actinopterygii mettl9 34 35
  • 58.2 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003602 34
  • 46.96 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5339 34 35
  • 46.35 (n)
(Caenorhabditis elegans)
Secernentea T03G11.6 34 35
  • 49.43 (n)
Species where no ortholog for METTL9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL9 Gene

Gene Tree for METTL9 (if available)
Gene Tree for METTL9 (if available)

Paralogs for METTL9 Gene

(1) SIMAP similar genes for METTL9 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with METTL9: view

No data available for Paralogs for METTL9 Gene

Variants for METTL9 Gene

Sequence variations from dbSNP and Humsavar for METTL9 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000065174 -- 21,631,613(+) CTATC(C/G)TCCTG intron-variant
rs1000074434 -- 21,651,162(+) AGCTT(G/T)CAGTG intron-variant
rs1000197427 -- 21,619,379(+) TGTTA(A/G)TCTTG intron-variant
rs1000246842 -- 21,606,118(+) GATCA(C/T)GAGGT intron-variant
rs1000298197 -- 21,637,866(+) AGGCC(A/G)AGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for METTL9 Gene

Variant ID Type Subtype PubMed ID
dgv116e55 CNV loss 17911159
dgv2800n100 CNV gain 25217958
dgv2803n100 CNV loss 25217958
dgv2804n100 CNV gain 25217958
dgv2805n100 CNV gain+loss 25217958
dgv2806n100 CNV gain 25217958
dgv2807n100 CNV loss 25217958
dgv2808n100 CNV gain+loss 25217958
dgv2809n100 CNV loss 25217958
dgv2810n100 CNV loss 25217958
dgv347n27 CNV gain 19166990
dgv348n27 CNV loss 19166990
dgv3n1 OTHER inversion 15895083
dgv3n29 CNV loss 16826518
dgv47n16 OTHER inversion 17901297
dgv4944n54 CNV loss 21841781
dgv4946n54 CNV gain+loss 21841781
dgv4947n54 CNV loss 21841781
dgv806e212 CNV loss 25503493
esv25717 CNV gain+loss 19812545
esv2751551 CNV gain 17911159
esv2751552 CNV loss 17911159
esv2758636 CNV gain+loss 17122850
esv2762010 CNV gain+loss 21179565
esv2763135 CNV gain 21179565
esv3368991 OTHER inversion 20981092
esv34235 CNV gain 17911159
esv3427100 CNV insertion 20981092
esv34544 CNV gain 17911159
esv3570431 CNV gain 25503493
esv3582094 CNV loss 25503493
esv3638186 CNV loss 21293372
esv3638187 CNV gain 21293372
esv3638188 CNV loss 21293372
esv3892812 CNV gain+loss 25118596
esv998989 OTHER inversion 20482838
nsv1077770 OTHER inversion 25765185
nsv1131233 CNV deletion 24896259
nsv1140248 OTHER inversion 24896259
nsv428322 CNV gain 18775914
nsv433438 CNV gain 18776910
nsv457460 CNV loss 19166990
nsv471086 CNV loss 18288195
nsv499139 OTHER inversion 21111241
nsv517713 CNV gain+loss 19592680
nsv571631 CNV loss 21841781
nsv571634 CNV gain 21841781
nsv571635 CNV gain 21841781
nsv571639 CNV loss 21841781
nsv571640 CNV loss 21841781
nsv7280 OTHER inversion 18451855
nsv817726 CNV gain 17921354
nsv9397 CNV gain+loss 18304495

Variation tolerance for METTL9 Gene

Residual Variation Intolerance Score: 35.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for METTL9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL9 Gene

Disorders for METTL9 Gene

MalaCards: The human disease database

(1) MalaCards diseases for METTL9 Gene - From: GeneCards

Disorder Aliases PubMed IDs
inflammatory bowel disease 1
  • crohn disease-associated growth failure
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for METTL9

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with METTL9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for METTL9 Gene

Publications for METTL9 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 64
  2. The mouse and human IGSF6 (DORA) genes map to the inflammatory bowel disease 1 locus and are embedded in an intron of a gene of unknown function. (PMID: 11132146) Bates E.E.M. … Lebecque S. (Immunogenetics 2000) 2 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Zinc finger protein tristetraprolin interacts with CCL3 mRNA and regulates tissue inflammation. (PMID: 21784977) Kang J.G. … Hwang P.M. (J. Immunol. 2011) 3 64
  5. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3 64

Products for METTL9 Gene

Sources for METTL9 Gene

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