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Aliases for METTL9 Gene

Aliases for METTL9 Gene

  • Methyltransferase Like 9 2 3
  • DORA Reverse Strand Protein 1 2 3
  • DREV1 3 4
  • DREV 3 4
  • Methyltransferase-Like Protein 9 3
  • DORA Reverse Strand Protein 4
  • P53 Activated Protein 1 3
  • CGI-81 3
  • PAP1 3

External Ids for METTL9 Gene

Summaries for METTL9 Gene

GeneCards Summary for METTL9 Gene

METTL9 (Methyltransferase Like 9) is a Protein Coding gene. Diseases associated with METTL9 include inflammatory bowel disease 1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL9 Gene

Genomics for METTL9 Gene

Genomic Location for METTL9 Gene

21,597,218 bp from pter
21,657,473 bp from pter
60,256 bases
Plus strand

Genomic View for METTL9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for METTL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL9 Gene

Regulatory Elements for METTL9 Gene

Proteins for METTL9 Gene

  • Protein details for METTL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Methyltransferase-like protein 9
    Protein Accession:
    Secondary Accessions:
    • Q8NBT8
    • Q9BWJ7
    • Q9H1A2
    • Q9Y390

    Protein attributes for METTL9 Gene

    318 amino acids
    Molecular mass:
    36536 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD34076.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for METTL9 Gene


neXtProt entry for METTL9 Gene

Proteomics data for METTL9 Gene at MOPED

Post-translational modifications for METTL9 Gene

No data available for DME Specific Peptides for METTL9 Gene

Domains for METTL9 Gene

Protein Domains for METTL9 Gene

Suggested Antigen Peptide Sequences for METTL9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DREV family.:
    • Q9H1A3
genes like me logo Genes that share domains with METTL9: view

No data available for Gene Families for METTL9 Gene

Function for METTL9 Gene

Gene Ontology (GO) - Molecular Function for METTL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21784977
GO:0008168 methyltransferase activity --
genes like me logo Genes that share ontologies with METTL9: view

Phenotypes for METTL9 Gene

GenomeRNAi human phenotypes for METTL9:
genes like me logo Genes that share phenotypes with METTL9: view

miRNA for METTL9 Gene

miRTarBase miRNAs that target METTL9

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for METTL9 Gene

Localization for METTL9 Gene

Subcellular locations from

Jensen Localization Image for METTL9 Gene COMPARTMENTS Subcellular localization image for METTL9 gene
Compartment Confidence
cytosol 2
mitochondrion 2
extracellular 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for METTL9 Gene

Pathways for METTL9 Gene

SuperPathways for METTL9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for METTL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with METTL9: view

No data available for Pathways by source for METTL9 Gene

Transcripts for METTL9 Gene

Unigene Clusters for METTL9 Gene

Methyltransferase like 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for METTL9 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d
SP1: - - - - -
SP2: - - - - -
SP4: -
SP5: - - -
SP6: -
SP7: - -

Relevant External Links for METTL9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL9 Gene

mRNA expression in normal human tissues for METTL9 Gene

mRNA differential expression in normal tissues according to GTEx for METTL9 Gene

This gene is overexpressed in Whole Blood (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for METTL9 Gene

SOURCE GeneReport for Unigene cluster for METTL9 Gene Hs.279583

genes like me logo Genes that share expressions with METTL9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for METTL9 Gene

Orthologs for METTL9 Gene

This gene was present in the common ancestor of animals.

Orthologs for METTL9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia METTL9 35
  • 99.68 (n)
  • 100 (a)
  • 100 (a)
(Bos Taurus)
Mammalia METTL9 35
  • 96.33 (n)
  • 99.37 (a)
  • 99 (a)
(Canis familiaris)
Mammalia METTL9 35
  • 96.23 (n)
  • 98.87 (a)
  • 96 (a)
(Mus musculus)
Mammalia Mettl9 35
  • 92.87 (n)
  • 97.17 (a)
Mettl9 16
Mettl9 36
  • 97 (a)
(Monodelphis domestica)
Mammalia METTL9 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia METTL9 36
  • 92 (a)
(Rattus norvegicus)
Mammalia Mettl9 35
  • 92.77 (n)
  • 97.48 (a)
(Gallus gallus)
Aves METTL9 35
  • 83.07 (n)
  • 87.94 (a)
  • 87 (a)
(Anolis carolinensis)
Reptilia METTL9 36
  • 85 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC53836 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl9 35
  • 72.76 (n)
  • 76.28 (a)
Str.3222 35
(Danio rerio)
Actinopterygii mettl9 35
  • 58.2 (n)
  • 56.76 (a)
mettl9 36
  • 58 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003602 35
  • 46.96 (n)
  • 41.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5339 35
  • 46.35 (n)
  • 39.45 (a)
CG5339 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea T03G11.6 35
  • 49.43 (n)
  • 41.44 (a)
T03G11.6 36
  • 35 (a)
Species with no ortholog for METTL9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL9 Gene

Gene Tree for METTL9 (if available)
Gene Tree for METTL9 (if available)

Paralogs for METTL9 Gene

Selected SIMAP similar genes for METTL9 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with METTL9: view

No data available for Paralogs for METTL9 Gene

Variants for METTL9 Gene

Sequence variations from dbSNP and Humsavar for METTL9 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs42747 -- 21,624,742(+) AAATT(A/T)AAAAA intron-variant
rs42748 -- 21,621,062(+) acttc(C/T)gggct intron-variant
rs42749 -- 21,619,611(-) aaaat(A/C)caaaa intron-variant
rs42750 -- 21,619,377(+) AGTGT(G/T)AATCT intron-variant
rs42751 -- 21,616,108(-) CACGG(A/T)GCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for METTL9 Gene

Variant ID Type Subtype PubMed ID
nsv905576 CNV Gain 21882294
esv34235 CNV Gain 17911159
dgv830e1 CNV Complex 17122850
esv25717 CNV Gain+Loss 19812545
nsv433438 CNV Gain 18776910
nsv905579 CNV Gain 21882294
nsv9397 CNV Gain+Loss 18304495
dgv2642n71 CNV Loss 21882294
essv17266 CNV CNV 17122850
dgv831e1 CNV Complex 17122850
dgv832e1 CNV Complex 17122850
nsv428322 CNV Gain 18775914
dgv2643n71 CNV Gain 21882294
esv2751551 CNV Gain 17911159
esv34544 CNV Gain 17911159
esv2751552 CNV Loss 17911159
dgv116e55 CNV Loss 17911159
nsv7280 OTHER Inversion 18451855
dgv347n27 CNV Gain 19166990
dgv348n27 CNV Loss 19166990
nsv471086 CNV Loss 18288195
nsv517713 CNV Gain+Loss 19592680
nsv817726 CNV Gain 17921354
dgv2644n71 CNV Loss 21882294
dgv3n1 OTHER Inversion 15895083
nsv511047 OTHER Inversion 20534489
dgv2645n71 CNV Gain+Loss 21882294
dgv2646n71 CNV Gain 21882294
nsv905590 CNV Gain 21882294
dgv47n16 OTHER Inversion 17901297
nsv499139 OTHER Inversion 21111241
esv998989 OTHER Inversion 20482838
dgv2n29 CNV Loss 16826518
dgv833e1 CNV Complex 17122850
essv3313 CNV CNV 17122850
nsv457460 CNV Loss 19166990

Relevant External Links for METTL9 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL9 Gene

Disorders for METTL9 Gene

Relevant External Links for METTL9

Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with METTL9: view

No data available for UniProtKB/Swiss-Prot for METTL9 Gene

Publications for METTL9 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  2. The mouse and human IGSF6 (DORA) genes map to the inflammatory bowel disease 1 locus and are embedded in an intron of a gene of unknown function. (PMID: 11132146) Bates E.E.M. … Lebecque S. (Immunogenetics 2000) 2 3 4
  3. Creation of genome-wide protein expression libraries using random activation of gene expression. (PMID: 11329013) Harrington J.J. … Ducar M. (Nat. Biotechnol. 2001) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3

Products for METTL9 Gene

Sources for METTL9 Gene

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