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Aliases for METTL9 Gene

Aliases for METTL9 Gene

  • Methyltransferase Like 9 2 3 5
  • DORA Reverse Strand Protein 1 2 3
  • DREV1 3 4
  • DREV 3 4
  • DORA Reverse Strand Protein 4
  • P53 Activated Protein 1 3
  • CTB-31N19.3 3
  • CGI-81 3
  • PAP1 3

External Ids for METTL9 Gene

Previous GeneCards Identifiers for METTL9 Gene

  • GC16P021519
  • GC16P019992

Summaries for METTL9 Gene

GeneCards Summary for METTL9 Gene

METTL9 (Methyltransferase Like 9) is a Protein Coding gene. Diseases associated with METTL9 include Inflammatory Bowel Disease 1. GO annotations related to this gene include methyltransferase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL9 Gene

Genomics for METTL9 Gene

Regulatory Elements for METTL9 Gene

Enhancers for METTL9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around METTL9 on UCSC Golden Path with GeneCards custom track

Genomic Location for METTL9 Gene

21,597,218 bp from pter
21,657,473 bp from pter
60,256 bases
Plus strand

Genomic View for METTL9 Gene

Genes around METTL9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL9 Gene

Proteins for METTL9 Gene

  • Protein details for METTL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Methyltransferase-like protein 9
    Protein Accession:
    Secondary Accessions:
    • Q8NBT8
    • Q9BWJ7
    • Q9H1A2
    • Q9Y390

    Protein attributes for METTL9 Gene

    318 amino acids
    Molecular mass:
    36536 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD34076.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for METTL9 Gene


neXtProt entry for METTL9 Gene

Proteomics data for METTL9 Gene at MOPED

Post-translational modifications for METTL9 Gene

No data available for DME Specific Peptides for METTL9 Gene

Domains & Families for METTL9 Gene

Gene Families for METTL9 Gene

Protein Domains for METTL9 Gene

Suggested Antigen Peptide Sequences for METTL9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DREV family.
  • Belongs to the DREV family.
genes like me logo Genes that share domains with METTL9: view

Function for METTL9 Gene

genes like me logo Genes that share phenotypes with METTL9: view

Animal Model Products

miRNA for METTL9 Gene

miRTarBase miRNAs that target METTL9

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL9 Gene

Localization for METTL9 Gene

Subcellular locations from

Jensen Localization Image for METTL9 Gene COMPARTMENTS Subcellular localization image for METTL9 gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2
extracellular 1
lysosome 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for METTL9 Gene

Pathways & Interactions for METTL9 Gene

SuperPathways for METTL9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for METTL9 Gene


No data available for Pathways by source and SIGNOR curated interactions for METTL9 Gene

Drugs & Compounds for METTL9 Gene

No Compound Related Data Available

Transcripts for METTL9 Gene

Unigene Clusters for METTL9 Gene

Methyltransferase like 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for METTL9 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d
SP1: - - - - -
SP2: - - - - -
SP4: -
SP5: - - -
SP6: -
SP7: - -

Relevant External Links for METTL9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL9 Gene

mRNA expression in normal human tissues for METTL9 Gene

mRNA differential expression in normal tissues according to GTEx for METTL9 Gene

This gene is overexpressed in Whole Blood (x7.6).

Protein differential expression in normal tissues from HIPED for METTL9 Gene

This gene is overexpressed in Bone (33.0), Monocytes (17.5), and Platelet (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for METTL9 Gene

SOURCE GeneReport for Unigene cluster for METTL9 Gene Hs.279583

genes like me logo Genes that share expression patterns with METTL9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for METTL9 Gene

Orthologs for METTL9 Gene

This gene was present in the common ancestor of animals.

Orthologs for METTL9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia METTL9 35
  • 96.33 (n)
  • 99.37 (a)
  • 99 (a)
(Canis familiaris)
Mammalia METTL9 35
  • 96.23 (n)
  • 98.87 (a)
  • 96 (a)
(Mus musculus)
Mammalia Mettl9 35
  • 92.87 (n)
  • 97.17 (a)
Mettl9 16
Mettl9 36
  • 97 (a)
(Pan troglodytes)
Mammalia METTL9 35
  • 99.68 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Mettl9 35
  • 92.77 (n)
  • 97.48 (a)
(Monodelphis domestica)
Mammalia METTL9 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia METTL9 36
  • 92 (a)
(Gallus gallus)
Aves METTL9 35
  • 83.07 (n)
  • 87.94 (a)
  • 87 (a)
(Anolis carolinensis)
Reptilia METTL9 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl9 35
  • 72.76 (n)
  • 76.28 (a)
Str.3222 35
African clawed frog
(Xenopus laevis)
Amphibia MGC53836 35
(Danio rerio)
Actinopterygii mettl9 35
  • 58.2 (n)
  • 56.76 (a)
mettl9 36
  • 58 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003602 35
  • 46.96 (n)
  • 41.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5339 35
  • 46.35 (n)
  • 39.45 (a)
CG5339 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea T03G11.6 35
  • 49.43 (n)
  • 41.44 (a)
T03G11.6 36
  • 35 (a)
Species with no ortholog for METTL9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL9 Gene

Gene Tree for METTL9 (if available)
Gene Tree for METTL9 (if available)

Paralogs for METTL9 Gene

(1) SIMAP similar genes for METTL9 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with METTL9: view

No data available for Paralogs for METTL9 Gene

Variants for METTL9 Gene

Sequence variations from dbSNP and Humsavar for METTL9 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs4088447 -- 21,631,735(+) gttgt(C/T)agtgg intron-variant
rs4102117 -- 21,631,825(+) cttca(A/G)ttatc intron-variant
rs4102118 -- 21,631,846(+) tttaa(A/C)tttac intron-variant
rs42747 -- 21,624,742(+) AAATT(A/T)AAAAA intron-variant
rs42748 -- 21,621,062(+) acttc(C/T)gggct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for METTL9 Gene

Variant ID Type Subtype PubMed ID
nsv905576 CNV Gain 21882294
esv34235 CNV Gain 17911159
dgv830e1 CNV Complex 17122850
esv25717 CNV Gain+Loss 19812545
nsv433438 CNV Gain 18776910
nsv905579 CNV Gain 21882294
nsv9397 CNV Gain+Loss 18304495
dgv2642n71 CNV Loss 21882294
essv17266 CNV CNV 17122850
dgv831e1 CNV Complex 17122850
dgv832e1 CNV Complex 17122850
nsv428322 CNV Gain 18775914
dgv2643n71 CNV Gain 21882294
esv2751551 CNV Gain 17911159
esv34544 CNV Gain 17911159
esv2751552 CNV Loss 17911159
dgv116e55 CNV Loss 17911159
nsv7280 OTHER Inversion 18451855
dgv347n27 CNV Gain 19166990
dgv348n27 CNV Loss 19166990
nsv471086 CNV Loss 18288195
nsv517713 CNV Gain+Loss 19592680
nsv817726 CNV Gain 17921354
dgv2644n71 CNV Loss 21882294
dgv3n1 OTHER Inversion 15895083
nsv511047 OTHER Inversion 20534489
dgv2645n71 CNV Gain+Loss 21882294
dgv2646n71 CNV Gain 21882294
nsv905590 CNV Gain 21882294
dgv47n16 OTHER Inversion 17901297
nsv499139 OTHER Inversion 21111241
esv998989 OTHER Inversion 20482838
dgv2n29 CNV Loss 16826518
dgv833e1 CNV Complex 17122850
essv3313 CNV CNV 17122850
nsv457460 CNV Loss 19166990

Variation tolerance for METTL9 Gene

Residual Variation Intolerance Score: 35.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.83% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for METTL9 Gene

Disorders for METTL9 Gene

MalaCards: The human disease database

(1) MalaCards diseases for METTL9 Gene - From: GeneCards

Disorder Aliases PubMed IDs
inflammatory bowel disease 1
  • crohn disease-associated growth failure
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for METTL9

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with METTL9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for METTL9 Gene

Publications for METTL9 Gene

  1. The mouse and human IGSF6 (DORA) genes map to the inflammatory bowel disease 1 locus and are embedded in an intron of a gene of unknown function. (PMID: 11132146) Bates E.E.M. … Lebecque S. (Immunogenetics 2000) 2 3 4 67
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Zinc finger protein tristetraprolin interacts with CCL3 mRNA and regulates tissue inflammation. (PMID: 21784977) Kang J.G. … Hwang P.M. (J. Immunol. 2011) 3
  5. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3

Products for METTL9 Gene

Sources for METTL9 Gene