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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

METTL9 Gene

protein-coding   GIFtS: 47
GCID: GC16P021610

Methyltransferase Like 9

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Methyltransferase Like 91 2     PAP12
DORA Reverse Strand Protein 11 2     Methyltransferase-Like Protein 92
DREV2 3     P53 Activated Protein 12
DREV12 3     DORA Reverse Strand Protein3

External Ids:    HGNC: 245861   Entrez Gene: 511082   Ensembl: ENSG000001970067   OMIM: 6093885   UniProtKB: Q9H1A33   

Export aliases for METTL9 gene to outside databases

Previous GC identifers: GC16P021519 GC16P019992


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for METTL9 Gene: 
METTL9 (methyltransferase like 9) is a protein-coding gene. Diseases associated with METTL9 include inflammatory bowel disease 1, and brain glioma. GO annotations related to this gene include protein binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the METTL9 gene promoter:
         HOXA9B   HOXA9   RP58   AML1a   HEN1   Egr-2   SRY   Meis-1a   Meis-1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMETTL9 promoter sequence
   Search SABiosciences Chromatin IP Primers for METTL9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.2   Ensembl cytogenetic band:  16p12.2   HGNC cytogenetic band: 16p12.2

METTL9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
METTL9 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P021610:  view genomic region     (about GC identifiers)

Start:
21,608,539 bp from pter      End:
21,668,794 bp from pter
Size:
60,256 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: METL9_HUMAN, Q9H1A3 (See protein sequence)
Recommended Name: Methyltransferase-like protein 9 precursor  
Size: 318 amino acids; 36536 Da
Sequence caution: Sequence=AAD34076.1; Type=Erroneous initiation;
Secondary accessions: Q8NBT8 Q9BWJ7 Q9H1A2 Q9Y390
Alternative splicing: 2 isoforms:  Q9H1A3-1   Q9H1A3-2   

Explore the universe of human proteins at neXtProt for METTL9: NX_Q9H1A3

Explore proteomics data for METTL9 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H1A3

  • METTL9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    METTL9 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001070648.1  NP_057109.3  

    ENSEMBL proteins: 
     ENSP00000454733   ENSP00000350874   ENSP00000379335   ENSP00000457311   ENSP00000456345  
     ENSP00000454239   ENSP00000455285   ENSP00000455720  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR007884 DREV_MeTrfase

    Graphical View of Domain Structure for InterPro Entry Q9H1A3

    ProtoNet protein and cluster: Q9H1A3

    UniProtKB/Swiss-Prot: METL9_HUMAN, Q9H1A3
    Similarity: Belongs to the DREV family


    METTL9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008168methyltransferase activity ----
         
    METTL9 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for METTL9:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for METTL9 
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    SwitchGear 3'UTR luciferase reporter plasmidMETTL9 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for METTL9

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for METTL9 (Q9H1A33 ENSP000003508744) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHMP6Q96FZ73, ENSP000003174684I2D: score=1 STRING: ENSP00000317468
    UBCENSP000003448184STRING: ENSP00000344818
    CACFD1ENSP000003171214STRING: ENSP00000317121
    MCTP2ENSP000003503774STRING: ENSP00000350377
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process ----

    METTL9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for METTL9 (METL9)

    Search CenterWatch for drugs/clinical trials and news about METTL9 / METL9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for METTL9 gene (2 alternative transcripts): 
    NM_001077180.1  NM_016025.3  

    Unigene Cluster for METTL9:

    Methyltransferase like 9
    Hs.279583  [show with all ESTs]
    Unigene Representative Sequence: NM_016025
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000563026 ENST00000567404 ENST00000358154(uc002dje.3 uc002djf.3)
    ENST00000396014 ENST00000562379 ENST00000570074 ENST00000562961 ENST00000568826
    ENST00000569290 ENST00000564733
    miRNA
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    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate METTL9 (see all 31):
    hsa-miR-3685 hsa-miR-137 hsa-miR-520d-5p hsa-miR-340 hsa-miR-507 hsa-miR-650 hsa-miR-141* hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidMETTL9 3' UTR sequence
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL9

    Additional mRNA sequence: 

    AF151839.1 AF497245.1 AJ278577.1 AJ278578.1 AK025565.1 AK074529.1 AK075022.1 AK075237.1 
    AK313077.1 AY093608.1 BC000195.1 

    23 DOTS entries:

    DT.87017121  DT.100770714  DT.100812844  DT.92045174  DT.456420  DT.95308339  DT.120658264  DT.100812841 
    DT.95111096  DT.100812843  DT.95158150  DT.92441608  DT.120658529  DT.100008218  DT.65285197  DT.97763971 
    DT.101962552  DT.120658330  DT.120658472  DT.120658672  DT.120658963  DT.92441604  DT.95158149 

    24/525 AceView cDNA sequences (see all 525):

    AI879728 AA157874 BF057346 AA397817 AI824115 Z39930 AI363318 BU621488 
    BM013572 AA904173 CB132414 AI879349 AI309548 CB160496 BU069216 N23189 
    AA713660 AI419900 BU625501 CB216760 BQ007760 AI088472 AK025565 AI459252 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for METTL9 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d
    SP1:        -     -     -     -     -                                                               
    SP2:        -     -     -     -     -                                                               
    SP3:                                                                                                
    SP4:                                -                                                               
    SP5:                                -     -     -                                                   


    ECgene alternative splicing isoforms for METTL9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    METTL9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAATAAACT
    METTL9 Expression
    About this image


    See METTL9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for METTL9

    SOURCE GeneReport for Unigene cluster: Hs.279583
        SABiosciences Custom PCR Arrays for METTL9
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for METTL9 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mettl91 , 5 methyltransferase like 91, 5 92.85(n)1
    97.16(a)1
      7 (65.07 cM)5
    590521  NM_021554.21  NP_067529.21 
     1210344455 
    chicken
    (Gallus gallus)
    Aves METTL91 methyltransferase like 9 83.12(n)
    88.22(a)
      416623  NM_001006172.1  NP_001006172.1 
    lizard
    (Anolis carolinensis)
    Reptilia METTL96
    Uncharacterized protein
    85(a)
    1 ↔ 1
    GL343507.1(4786-30440)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC538362 hypothetical protein MGC53836 75.39(n)    BC045080.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1530601 zgc:153060 58.56(n)
    58.38(a)
      768200  NM_001077342.1  NP_001070810.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG53391 CG5339 45.91(n)
    38.52(a)
      37794  NM_138002.3  NP_611846.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T03G11.61 Protein T03G11.6 49.06(n)
    41.2(a)
      188034  NM_076479.4  NP_508880.2 


    ENSEMBL Gene Tree for METTL9 (if available)
    TreeFam Gene Tree for METTL9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for METTL9 gene
    1 SIMAP similar gene for METTL9 using alignment to 7 protein entries:     METL9_HUMAN (see all proteins):
    PAP1

    METTL9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/782 SNPs in METTL9 are shown (see all 782)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs735458671,2
    C,F--21608939(+) CACTCT/CATAGC 2 -- us2k12Minor allele frequency- C:0.09WA 120
    rs1915752711,2
    --21609055(+) TGACAC/GAGTTG 2 -- us2k10--------
    rs1407064551,2
    --21609060(+) GAGTTG/TCTTTG 2 -- us2k10--------
    rs1829788001,2
    --21609125(+) GTTATC/TGGACT 2 -- us2k10--------
    rs1459146231,2
    --21609160(+) ACTTGA/GGCCAG 2 -- us2k10--------
    rs1945491,2
    C,H--21609377(+) CTAATA/GAAAGA 2 -- us2k115Minor allele frequency- G:0.00NS NA WA CSA EA 553
    rs559389931,2
    --21609631(+) AGCCAC/TTGCAC 2 -- us2k10--------
    rs1945501,2
    C--21609793(+) CAAAAG/TGCTTA 2 -- us2k12Minor allele frequency- T:0.07NA EA 122
    rs1945511,2
    C--21609840(+) TTCTGG/ATGCAG 2 -- us2k14Minor allele frequency- A:0.05MN NA EA 1802
    rs1929197091,2
    --21609904(+) TCCCAC/TGAAAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for METTL9 (21608539 - 21668794 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/36 variations for METTL9 (see all 36):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv348n27CNV Loss19166990
    dgv2n29CNV Loss16826518
    nsv471086CNV Loss18288195
    dgv2644n71CNV Loss21882294
    dgv116e55CNV Loss17911159
    dgv2642n71CNV Loss21882294
    esv2751552CNV Loss17911159
    nsv457460CNV Loss19166990
    esv34544CNV Gain17911159
    dgv2643n71CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing METTL9
    DNA2.0 Custom Variant and Variant Library Synthesis for METTL9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609388    OMIM disorders: --

    5 diseases for METTL9:    About MalaCards
    inflammatory bowel disease 1    brain glioma    inflammatory bowel disease    hepatitis b
    hepatitis


    METTL9 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: METTL9 (2 documents)

    Export disorders for METTL9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for METTL9 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with METTL9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The mouse and human IGSF6 (DORA) genes map to the inflammatory bowel disease 1 locus and are embedded in an intron of a gene of unknown function. (PubMed id 11132146)1, 2, 3 Bates E.E.M.... Lebecque S. (2000)
    2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
    3. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    4. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    5. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
    6. Effects of exogenous p53 transfection on the gene exp ression in the human brain glioma cell line U251. (PubMed id 16413759)1 Shu K.X....Wei J.M. (2006)
    7. A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. (PubMed id 16730941)1 Tsang H.T.H....Sanderson C.M. (2006)
    8. Characterization of the human PAP1 gene and its homologue possible involvement in mouse embryonic development. (PubMed id 16837177)1 Shu K.X....Li B. (2006)
    9. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51108 HGNC: 24586 AceView: DREV1 Ensembl:ENSG00000197006 euGenes: HUgn51108
    ECgene: METTL9 H-InvDB: METTL9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for METTL9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for METTL9 gene:
    Search GeneIP for patents involving METTL9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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