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Aliases for METTL8 Gene

Aliases for METTL8 Gene

  • Methyltransferase Like 8 2 3 5
  • Tension-Induced/Inhibited Protein 2 3
  • Methyltransferase-Like Protein 8 3
  • EC 2.1.1.- 4
  • TIP 3

External Ids for METTL8 Gene

Previous GeneCards Identifiers for METTL8 Gene

  • GC02M171888
  • GC02M172173
  • GC02M164059

Summaries for METTL8 Gene

GeneCards Summary for METTL8 Gene

METTL8 (Methyltransferase Like 8) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity and histone acetyltransferase activity. An important paralog of this gene is METTL2A.

UniProtKB/Swiss-Prot for METTL8 Gene

  • Probable methyltransferase.

Additional gene information for METTL8 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL8 Gene

Genomics for METTL8 Gene

Regulatory Elements for METTL8 Gene

Enhancers for METTL8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H171314 1.4 Ensembl ENCODE dbSUPER 11.5 +113.4 113352 14.2 HDGF PKNOX1 FOXA2 SIN3A ETS1 ZNF207 ATF7 RUNX3 JUNB REST METTL8 CYBRD1 GC02M171318 GC02M171323 GC02M171324
GH02H171403 1.1 Ensembl ENCODE 12.1 +29.3 29336 4.8 HDGF PKNOX1 FOXA2 TBL1XR1 BATF ZNF143 ATF7 ETV6 RUNX3 CREM METTL8 CYBRD1 GC02M171404 GC02P171375
GH02H171244 1.6 FANTOM5 Ensembl ENCODE 5.2 +189.7 189663 2.1 PKNOX1 ATF1 FOXA2 ARNT ZNF766 CBX5 ELK1 ATF7 CAVIN1 NCOA1 DCAF17 GORASP2 METAP1D DAP3P2 METTL8 TLK1 GC02M171274
GH02H171271 1.1 Ensembl ENCODE 6.9 +162.7 162689 1.2 TBP PKNOX1 FOXA2 BMI1 RAD21 RFX5 SCRT2 RCOR1 FOS CEBPB TLK1 METTL8 METAP1D GC02M171274
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around METTL8 on UCSC Golden Path with GeneCards custom track

Promoters for METTL8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for METTL8 Gene

Genomic Locations for METTL8 Gene
117,401 bases
Minus strand

Genomic View for METTL8 Gene

Genes around METTL8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL8 Gene

Proteins for METTL8 Gene

  • Protein details for METTL8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Methyltransferase-like protein 8
    Protein Accession:
    Secondary Accessions:
    • Q53TM9
    • Q53TQ0

    Protein attributes for METTL8 Gene

    291 amino acids
    Molecular mass:
    33387 Da
    Quaternary structure:
    • Interacts with EP300.
    • Sequence=AAH25250.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAX93077.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for METTL8 Gene


neXtProt entry for METTL8 Gene

Post-translational modifications for METTL8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for METTL8 Gene

Domains & Families for METTL8 Gene

Gene Families for METTL8 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for METTL8 Gene

Suggested Antigen Peptide Sequences for METTL8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the methyltransferase superfamily. METL family.
  • Belongs to the methyltransferase superfamily. METL family.
genes like me logo Genes that share domains with METTL8: view

Function for METTL8 Gene

Molecular function for METTL8 Gene

UniProtKB/Swiss-Prot Function:
Probable methyltransferase.

Enzyme Numbers (IUBMB) for METTL8 Gene

Phenotypes From GWAS Catalog for METTL8 Gene

Gene Ontology (GO) - Molecular Function for METTL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with METTL8: view

Phenotypes for METTL8 Gene

MGI mutant phenotypes for METTL8:
inferred from 1 alleles
GenomeRNAi human phenotypes for METTL8:
genes like me logo Genes that share phenotypes with METTL8: view

miRNA for METTL8 Gene

miRTarBase miRNAs that target METTL8

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL8 Gene

Localization for METTL8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL8 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL8 gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for METTL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with METTL8: view

Pathways & Interactions for METTL8 Gene

SuperPathways for METTL8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for METTL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007519 skeletal muscle tissue development IEA --
GO:0016573 histone acetylation IEA --
GO:0032259 methylation IEA --
GO:0045444 fat cell differentiation IEA --
genes like me logo Genes that share ontologies with METTL8: view

No data available for Pathways by source and SIGNOR curated interactions for METTL8 Gene

Drugs & Compounds for METTL8 Gene

No Compound Related Data Available

Transcripts for METTL8 Gene

Unigene Clusters for METTL8 Gene

Methyltransferase like 8:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c
SP1: - -
SP2: - - -
SP3: -
SP5: - - -

Relevant External Links for METTL8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for METTL8 Gene

Protein differential expression in normal tissues from HIPED for METTL8 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for METTL8 Gene

Protein tissue co-expression partners for METTL8 Gene

NURSA nuclear receptor signaling pathways regulating expression of METTL8 Gene:


SOURCE GeneReport for Unigene cluster for METTL8 Gene:


Evidence on tissue expression from TISSUES for METTL8 Gene

  • Liver(4.2)
genes like me logo Genes that share expression patterns with METTL8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL8 Gene

Orthologs for METTL8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for METTL8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia METTL8 33 34
  • 99.59 (n)
(Canis familiaris)
Mammalia METTL8 33 34
  • 90.2 (n)
(Bos Taurus)
Mammalia METTL8 33 34
  • 89.03 (n)
(Mus musculus)
Mammalia Mettl8 33 16 34
  • 79.5 (n)
(Rattus norvegicus)
Mammalia Mettl8 33
  • 76.92 (n)
(Ornithorhynchus anatinus)
Mammalia METTL8 34
  • 69 (a)
(Monodelphis domestica)
Mammalia METTL8 34
  • 66 (a)
(Gallus gallus)
Aves METTL8 33 34
  • 72.35 (n)
(Anolis carolinensis)
Reptilia METTL8 34
  • 56 (a)
(Danio rerio)
Actinopterygii mettl8 33 34
  • 60.12 (n)
fruit fly
(Drosophila melanogaster)
Insecta metl 34
  • 40 (a)
(Caenorhabditis elegans)
Secernentea Y53F4B.42 34
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ABP140 34
  • 18 (a)
Species where no ortholog for METTL8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for METTL8 Gene

Gene Tree for METTL8 (if available)
Gene Tree for METTL8 (if available)

Paralogs for METTL8 Gene

Paralogs for METTL8 Gene

(4) SIMAP similar genes for METTL8 Gene using alignment to 7 proteins: Pseudogenes for METTL8 Gene

genes like me logo Genes that share paralogs with METTL8: view

Variants for METTL8 Gene

Sequence variations from dbSNP and Humsavar for METTL8 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs6751956 Likely benign 171,435,106(+) AATGT(C/T)TGGAC nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime
rs146556466 Uncertain significance 171,435,068(+) AAATT(A/C)TTTAT intron-variant, upstream-variant-2KB
rs147113116 Uncertain significance 171,434,374(+) TCTCT(C/T)CGCGC intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs201346228 Uncertain significance 171,435,140(+) CCTAT(A/G)AGAGA nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs375426959 Uncertain significance 171,435,093(+) TACTA(A/T)ATTTA nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for METTL8 Gene

Variant ID Type Subtype PubMed ID
nsv979147 CNV duplication 23825009
nsv1003130 CNV loss 25217958

Variation tolerance for METTL8 Gene

Gene Damage Index Score: 3.34; 53.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for METTL8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL8 Gene

Disorders for METTL8 Gene

Relevant External Links for METTL8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for METTL8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL8 Gene

Publications for METTL8 Gene

  1. TIPs are tension-responsive proteins involved in myogenic versus adipogenic differentiation. (PMID: 15992539) Jakkaraju S … Schuger L (Developmental cell 2005) 2 3 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60
  5. Multiple loci influencing hippocampal degeneration identified by genome scan. (PMID: 22745009) Melville SA … Alzheimer's Disease Neuroimaging Initiative (Annals of neurology 2012) 3 60

Products for METTL8 Gene

Sources for METTL8 Gene

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