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Aliases for METTL8 Gene

Aliases for METTL8 Gene

  • Methyltransferase Like 8 2 3
  • Tension-Induced/Inhibited Protein 2 3
  • Methyltransferase-Like Protein 8 3
  • EC 2.1.1.- 4
  • TIP 3

External Ids for METTL8 Gene

Previous GeneCards Identifiers for METTL8 Gene

  • GC02M171888
  • GC02M172173
  • GC02M164059

Summaries for METTL8 Gene

GeneCards Summary for METTL8 Gene

METTL8 (Methyltransferase Like 8) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is METTL2A.

UniProtKB/Swiss-Prot for METTL8 Gene

  • Probable methyltransferase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL8 Gene

Genomics for METTL8 Gene

Regulatory Elements for METTL8 Gene

Genomic Location for METTL8 Gene

Start:
171,317,402 bp from pter
End:
171,434,802 bp from pter
Size:
117,401 bases
Orientation:
Minus strand

Genomic View for METTL8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for METTL8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL8 Gene

Proteins for METTL8 Gene

  • Protein details for METTL8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H825-METL8_HUMAN
    Recommended name:
    Methyltransferase-like protein 8
    Protein Accession:
    Q9H825
    Secondary Accessions:
    • Q53TM9
    • Q53TQ0

    Protein attributes for METTL8 Gene

    Size:
    291 amino acids
    Molecular mass:
    33387 Da
    Quaternary structure:
    • Interacts with EP300.
    SequenceCaution:
    • Sequence=AAH25250.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAX93077.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for METTL8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for METTL8 Gene

Proteomics data for METTL8 Gene at MOPED

Post-translational modifications for METTL8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for METTL8 Gene

Domains for METTL8 Gene

Protein Domains for METTL8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for METTL8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H825

UniProtKB/Swiss-Prot:

METL8_HUMAN :
  • Q9H825
Family:
  • Belongs to the methyltransferase superfamily. METL family.
genes like me logo Genes that share domains with METTL8: view

No data available for Gene Families for METTL8 Gene

Function for METTL8 Gene

Molecular function for METTL8 Gene

UniProtKB/Swiss-Prot Function: Probable methyltransferase.

Enzyme Numbers (IUBMB) for METTL8 Gene

Gene Ontology (GO) - Molecular Function for METTL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004402 histone acetyltransferase activity --
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with METTL8: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for METTL8 Gene

Localization for METTL8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL8 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for METTL8 Gene COMPARTMENTS Subcellular localization image for METTL8 gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for METTL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with METTL8: view

Pathways for METTL8 Gene

SuperPathways for METTL8 Gene

No Data Available

Interacting Proteins for METTL8 Gene

Gene Ontology (GO) - Biological Process for METTL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007519 skeletal muscle tissue development --
GO:0008152 metabolic process --
GO:0016573 histone acetylation --
GO:0032259 methylation IEA --
GO:0045444 fat cell differentiation --
genes like me logo Genes that share ontologies with METTL8: view

No data available for Pathways by source for METTL8 Gene

Transcripts for METTL8 Gene

Unigene Clusters for METTL8 Gene

Methyltransferase like 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for METTL8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c
SP1: - -
SP2: - - -
SP3: -
SP4:
SP5: - - -

Relevant External Links for METTL8 Gene

GeneLoc Exon Structure for
METTL8
ECgene alternative splicing isoforms for
METTL8

Expression for METTL8 Gene

mRNA expression in normal human tissues for METTL8 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for METTL8 Gene

SOURCE GeneReport for Unigene cluster for METTL8 Gene Hs.135146

genes like me logo Genes that share expressions with METTL8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for METTL8 Gene

Orthologs for METTL8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for METTL8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL8 35
  • 99.59 (n)
  • 99.02 (a)
METTL8 36
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia METTL8 35
  • 89.03 (n)
  • 85.26 (a)
METTL8 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia METTL8 35
  • 90.2 (n)
  • 85.93 (a)
METTL8 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mettl8 35
  • 79.5 (n)
  • 75.19 (a)
Mettl8 16
Mettl8 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia METTL8 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia METTL8 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mettl8 35
  • 76.92 (n)
  • 68.21 (a)
chicken
(Gallus gallus)
Aves METTL8 35
  • 72.35 (n)
  • 67.94 (a)
METTL8 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia METTL8 36
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mettl8 35
  • 60.12 (n)
  • 59.51 (a)
mettl8 36
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta metl 36
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y53F4B.42 36
  • 40 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ABP140 36
  • 18 (a)
OneToMany
Species with no ortholog for METTL8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for METTL8 Gene

ENSEMBL:
Gene Tree for METTL8 (if available)
TreeFam:
Gene Tree for METTL8 (if available)

Paralogs for METTL8 Gene

Paralogs for METTL8 Gene

Selected SIMAP similar genes for METTL8 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for METTL8 Gene

genes like me logo Genes that share paralogs with METTL8: view

Variants for METTL8 Gene

Sequence variations from dbSNP and Humsavar for METTL8 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs727231 -- 171,422,184(-) TATCT(A/G)GTCAA intron-variant
rs728651 -- 171,398,961(-) TGAAA(C/G)ACCTT intron-variant
rs888521 -- 171,362,114(-) TGACC(A/G)TTACC intron-variant
rs1125991 -- 171,406,938(-) ttggt(A/T)gcaga intron-variant
rs1178005 -- 171,374,028(-) aagct(A/G)ccaat intron-variant

Relevant External Links for METTL8 Gene

HapMap Linkage Disequilibrium report
METTL8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for METTL8 Gene

Disorders for METTL8 Gene

No disorders were found for METTL8 Gene.

No data available for UniProtKB/Swiss-Prot for METTL8 Gene

Publications for METTL8 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. TIPs are tension-responsive proteins involved in myogenic versus adipogenic differentiation. (PMID: 15992539) Jakkaraju S. … Schuger L. (Dev. Cell 2005) 2 3
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Multiple loci influencing hippocampal degeneration identified by genome scan. (PMID: 22745009) Melville S.A. … Farrer L.A. (Ann. Neurol. 2012) 3

Products for METTL8 Gene

Sources for METTL8 Gene

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