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Aliases for METTL7B Gene

Aliases for METTL7B Gene

  • Methyltransferase Like 7B 2 3 5
  • Associated With Lipid Droplets 1 2 3
  • Methyltransferase-Like Protein 7B 3
  • EC 2.1.1.- 4
  • EC 2.1.1 58
  • ALDI 3

External Ids for METTL7B Gene

Previous GeneCards Identifiers for METTL7B Gene

  • GC12P054362
  • GC12P056075
  • GC12P053114

Summaries for METTL7B Gene

GeneCards Summary for METTL7B Gene

METTL7B (Methyltransferase Like 7B) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity and S-adenosylmethionine-dependent methyltransferase activity. An important paralog of this gene is METTL7A.

UniProtKB/Swiss-Prot for METTL7B Gene

  • Probable methyltransferase.

Additional gene information for METTL7B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL7B Gene

Genomics for METTL7B Gene

Regulatory Elements for METTL7B Gene

Enhancers for METTL7B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H055680 1.3 Ensembl ENCODE 43.6 +0.5 474 2.4 ARID4B SIN3A DMAP1 YY1 GLIS2 ZNF143 ATF7 SP3 YY2 REST METTL7B PAN2 PHC1P1 ENSG00000257509 DNAJC14 TMEM198B SMARCC2 CNPY2 ANKRD52 OR10P1
GH12H055676 0.5 FANTOM5 43.2 -4.7 -4715 0.2 CEBPB CEBPG METTL7B MMP19 BLOC1S1 ITGA7 ZC3H10 ENSG00000270458
GH12H055673 0.9 Ensembl ENCODE 16.2 -7.7 -7681 1.3 ZNF687 POLR2A NR2F1 IKZF1 NBN ELF1 MLLT1 SPI1 METTL7B BLOC1S1 ITGA7 RDH5 ENSG00000270458
GH12H055702 1.2 ENCODE dbSUPER 11.4 +25.1 25104 8.1 FOXA2 GLIS2 ATF7 SP3 SP5 GLIS1 WT1 SP7 FOXP1 CTCF ITGA7 RN7SL809P OR10A7 OR6C74 RPL41 RBMS2 METTL7B BAZ2A CD63 GDF11
GH12H056078 1.7 FANTOM5 ENCODE dbSUPER 3.1 +399.8 399750 6.1 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B SUOX BAZ2A RAB5B ENSG00000258317 ZC3H10 ANKRD52 PAN2 SMARCC2 ENSG00000257303 RPS26
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around METTL7B on UCSC Golden Path with GeneCards custom track

Genomic Locations for METTL7B Gene

Genomic Locations for METTL7B Gene
3,066 bases
Plus strand

Genomic View for METTL7B Gene

Genes around METTL7B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL7B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL7B Gene

Proteins for METTL7B Gene

  • Protein details for METTL7B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Methyltransferase-like protein 7B
    Protein Accession:
    Secondary Accessions:
    • A8K247
    • Q8WUI1

    Protein attributes for METTL7B Gene

    244 amino acids
    Molecular mass:
    27775 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ88872.1; Type=Erroneous termination; Positions=245; Note=Translated as stop.; Evidence={ECO:0000305}; Sequence=BAF82801.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for METTL7B Gene

Selected DME Specific Peptides for METTL7B Gene


Post-translational modifications for METTL7B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for METTL7B Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for METTL7B Gene

Gene Families for METTL7B Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for METTL7B Gene

Suggested Antigen Peptide Sequences for METTL7B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the methyltransferase superfamily.
  • Belongs to the methyltransferase superfamily.
genes like me logo Genes that share domains with METTL7B: view

Function for METTL7B Gene

Molecular function for METTL7B Gene

UniProtKB/Swiss-Prot Function:
Probable methyltransferase.

Enzyme Numbers (IUBMB) for METTL7B Gene

Phenotypes From GWAS Catalog for METTL7B Gene

Gene Ontology (GO) - Molecular Function for METTL7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with METTL7B: view
genes like me logo Genes that share phenotypes with METTL7B: view

Animal Models for METTL7B Gene

MGI Knock Outs for METTL7B:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for METTL7B Gene

Localization for METTL7B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL7B gene
Compartment Confidence
extracellular 3
plasma membrane 2
cytoskeleton 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (3)
  • Vesicles (3)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for METTL7B Gene

Pathways & Interactions for METTL7B Gene

SuperPathways for METTL7B Gene

No Data Available

Interacting Proteins for METTL7B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000377796 Q6UX53-MET7B_HUMAN for METTL7B Gene via STRING IID

Gene Ontology (GO) - Biological Process for METTL7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL7B: view

No data available for Pathways by source and SIGNOR curated interactions for METTL7B Gene

Drugs & Compounds for METTL7B Gene

No Compound Related Data Available

Transcripts for METTL7B Gene

mRNA/cDNA for METTL7B Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(85) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for METTL7B Gene

Methyltransferase like 7B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL7B Gene

No ASD Table

Relevant External Links for METTL7B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL7B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for METTL7B Gene

mRNA differential expression in normal tissues according to GTEx for METTL7B Gene

This gene is overexpressed in Heart - Atrial Appendage (x18.0) and Liver (x13.5).

Protein differential expression in normal tissues from HIPED for METTL7B Gene

This gene is overexpressed in Liver (27.8), Fetal gut (15.0), and Kidney (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for METTL7B Gene

Protein tissue co-expression partners for METTL7B Gene

NURSA nuclear receptor signaling pathways regulating expression of METTL7B Gene:


SOURCE GeneReport for Unigene cluster for METTL7B Gene:


Evidence on tissue expression from TISSUES for METTL7B Gene

  • Liver(4.5)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with METTL7B: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL7B Gene

Orthologs for METTL7B Gene

This gene was present in the common ancestor of chordates.

Orthologs for METTL7B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia METTL7B 33 34
  • 100 (n)
(Canis familiaris)
Mammalia METTL7B 33 34
  • 89.09 (n)
(Bos Taurus)
Mammalia METTL7B 33 34
  • 86.07 (n)
(Mus musculus)
Mammalia Mettl7b 33 16 34
  • 84.3 (n)
(Rattus norvegicus)
Mammalia Mettl7b 33
  • 83.11 (n)
(Monodelphis domestica)
Mammalia METTL7B 34
  • 77 (a)
(Gallus gallus)
Aves -- 34
  • 54 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 59 (a)
-- 34
  • 48 (a)
(Danio rerio)
Actinopterygii si:ch211-173n18.3 34
  • 47 (a)
mettl7a 34
  • 45 (a)
si:ch211-173n18.4 34
  • 45 (a)
Species where no ortholog for METTL7B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for METTL7B Gene

Gene Tree for METTL7B (if available)
Gene Tree for METTL7B (if available)

Paralogs for METTL7B Gene

Paralogs for METTL7B Gene

(1) SIMAP similar genes for METTL7B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with METTL7B: view

Variants for METTL7B Gene

Sequence variations from dbSNP and Humsavar for METTL7B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs139711828 Uncertain significance 55,684,669(+) AGGAG(C/G)AGCCT intron-variant, utr-variant-3-prime
rs144436282 Uncertain significance 55,684,963(+) TGATG(C/T)GACAC intron-variant, utr-variant-3-prime
rs146354904 Uncertain significance 55,684,640(+) TAAGG(C/T)CAGAT intron-variant, utr-variant-3-prime
rs886049661 Uncertain significance 55,684,700(-) AGGGT(C/T)GGGGA downstream-variant-500B, utr-variant-3-prime
rs886049662 Uncertain significance 55,684,749(-) GTGTA(A/G)CAGGA downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for METTL7B Gene

Variant ID Type Subtype PubMed ID
nsv525231 CNV loss 19592680

Variation tolerance for METTL7B Gene

Residual Variation Intolerance Score: 81.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.63; 56.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for METTL7B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL7B Gene

Disorders for METTL7B Gene

Relevant External Links for METTL7B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for METTL7B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL7B Gene

Publications for METTL7B Gene

  1. Identification and characterization of associated with lipid droplet protein 1: A novel membrane-associated protein that resides on hepatic lipid droplets. (PMID: 17004324) Turró S … Pol A (Traffic (Copenhagen, Denmark) 2006) 2 3 60
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 60

Products for METTL7B Gene

Sources for METTL7B Gene

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