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Aliases for METTL7B Gene

Aliases for METTL7B Gene

  • Methyltransferase Like 7B 2 3 5
  • Associated With Lipid Droplets 1 2 3
  • Methyltransferase-Like Protein 7B 3
  • EC 2.1.1.- 4
  • EC 2.1.1 61
  • ALDI 3

External Ids for METTL7B Gene

Previous GeneCards Identifiers for METTL7B Gene

  • GC12P054362
  • GC12P056075
  • GC12P053114

Summaries for METTL7B Gene

GeneCards Summary for METTL7B Gene

METTL7B (Methyltransferase Like 7B) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity and S-adenosylmethionine-dependent methyltransferase activity. An important paralog of this gene is METTL7A.

UniProtKB/Swiss-Prot for METTL7B Gene

  • Probable methyltransferase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL7B Gene

Genomics for METTL7B Gene

Regulatory Elements for METTL7B Gene

Enhancers for METTL7B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F055680 0.4 ENCODE 43.6 +0.5 474 2.4 ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 ZNF143 SP3 YY2 KAT8 METTL7B PHC1P1 ENSG00000257509 TMEM198B SMARCC2 CNPY2 ANKRD52 OR10P1 BLOC1S1 BLOC1S1-RDH5
GH12F055676 0.7 FANTOM5 43.2 -4.7 -4715 0.2 CEBPB METTL7B MMP19 BLOC1S1 ITGA7 ZC3H10 ENSG00000270458
GH12F055673 0.7 Ensembl ENCODE 16.2 -7.7 -7692 1.3 MTA2 POLR2A IKZF1 NBN MLLT1 SPI1 METTL7B BLOC1S1 ITGA7 RDH5 ENSG00000270458
GH12F055702 0.4 ENCODE 11.4 +25.1 25104 8.1 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 RPL41 RBMS2 RNU6-343P CDK2 ESYT1 ITGA7 LOC100131294 OR10A7 OR6C74 RN7SL809P
GH12F054997 0.5 ENCODE 6 -683.3 -683315 1.3 ZNF680 POU5F1 KDM1A NEUROD4 METTL7B TESPA1 GC12M054982
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around METTL7B on UCSC Golden Path with GeneCards custom track

Promoters for METTL7B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001777551 1054 2001 ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 ZNF143 SP3 YY2 KAT8

Genomic Location for METTL7B Gene

55,681,546 bp from pter
55,684,611 bp from pter
3,066 bases
Plus strand

Genomic View for METTL7B Gene

Genes around METTL7B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL7B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL7B Gene

Proteins for METTL7B Gene

  • Protein details for METTL7B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Methyltransferase-like protein 7B
    Protein Accession:
    Secondary Accessions:
    • A8K247
    • Q8WUI1

    Protein attributes for METTL7B Gene

    244 amino acids
    Molecular mass:
    27775 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ88872.1; Type=Erroneous termination; Positions=245; Note=Translated as stop.; Evidence={ECO:0000305}; Sequence=BAF82801.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for METTL7B Gene

Selected DME Specific Peptides for METTL7B Gene


Post-translational modifications for METTL7B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for METTL7B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for METTL7B
  • Santa Cruz Biotechnology (SCBT) Antibodies for METTL7B

Domains & Families for METTL7B Gene

Gene Families for METTL7B Gene

Protein Domains for METTL7B Gene

Suggested Antigen Peptide Sequences for METTL7B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the methyltransferase superfamily.
  • Belongs to the methyltransferase superfamily.
genes like me logo Genes that share domains with METTL7B: view

Function for METTL7B Gene

Molecular function for METTL7B Gene

UniProtKB/Swiss-Prot Function:
Probable methyltransferase.

Enzyme Numbers (IUBMB) for METTL7B Gene

Gene Ontology (GO) - Molecular Function for METTL7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity IBA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with METTL7B: view
genes like me logo Genes that share phenotypes with METTL7B: view

Animal Models for METTL7B Gene

MGI Knock Outs for METTL7B:

Animal Model Products

  • Taconic Biosciences Mouse Models for METTL7B

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for METTL7B Gene

Localization for METTL7B Gene

Subcellular locations from

Jensen Localization Image for METTL7B Gene COMPARTMENTS Subcellular localization image for METTL7B gene
Compartment Confidence
extracellular 3
cytoskeleton 2
plasma membrane 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for METTL7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with METTL7B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for METTL7B Gene

Pathways & Interactions for METTL7B Gene

SuperPathways for METTL7B Gene

No Data Available

Interacting Proteins for METTL7B Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000377796 Q6UX53-MET7B_HUMAN for METTL7B Gene via STRING IID

Gene Ontology (GO) - Biological Process for METTL7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0032259 methylation IEA,IBA --
genes like me logo Genes that share ontologies with METTL7B: view

No data available for Pathways by source and SIGNOR curated interactions for METTL7B Gene

Transcripts for METTL7B Gene

mRNA/cDNA for METTL7B Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(85) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for METTL7B Gene

Methyltransferase like 7B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL7B Gene

No ASD Table

Relevant External Links for METTL7B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL7B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for METTL7B Gene

mRNA differential expression in normal tissues according to GTEx for METTL7B Gene

This gene is overexpressed in Heart - Atrial Appendage (x18.0) and Liver (x13.5).

Protein differential expression in normal tissues from HIPED for METTL7B Gene

This gene is overexpressed in Liver (27.8), Fetal gut (15.0), and Kidney (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for METTL7B Gene

Protein tissue co-expression partners for METTL7B Gene

NURSA nuclear receptor signaling pathways regulating expression of METTL7B Gene:


SOURCE GeneReport for Unigene cluster for METTL7B Gene:

genes like me logo Genes that share expression patterns with METTL7B: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for METTL7B Gene

Orthologs for METTL7B Gene

This gene was present in the common ancestor of chordates.

Orthologs for METTL7B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia METTL7B 34 35
  • 100 (n)
(Canis familiaris)
Mammalia METTL7B 34 35
  • 89.09 (n)
(Bos Taurus)
Mammalia METTL7B 34 35
  • 86.07 (n)
(Mus musculus)
Mammalia Mettl7b 34 16 35
  • 84.3 (n)
(Rattus norvegicus)
Mammalia Mettl7b 34
  • 83.11 (n)
(Monodelphis domestica)
Mammalia METTL7B 35
  • 77 (a)
(Gallus gallus)
Aves -- 35
  • 54 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 59 (a)
-- 35
  • 48 (a)
(Danio rerio)
Actinopterygii si:ch211-173n18.3 35
  • 47 (a)
mettl7a 35
  • 45 (a)
si:ch211-173n18.4 35
  • 45 (a)
Species where no ortholog for METTL7B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for METTL7B Gene

Gene Tree for METTL7B (if available)
Gene Tree for METTL7B (if available)

Paralogs for METTL7B Gene

Paralogs for METTL7B Gene

(1) SIMAP similar genes for METTL7B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with METTL7B: view

Variants for METTL7B Gene

Sequence variations from dbSNP and Humsavar for METTL7B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs148170949 other 55,685,088(+) CCATC(A/G)GGGCC intron-variant, reference, synonymous-codon, utr-variant-3-prime
rs1048103 -- 55,684,405(+) GGCTA(C/T)ACCCA downstream-variant-500B, utr-variant-3-prime
rs10600907 -- 55,682,810(+) AAAAG(-/AG/GA)AGAGA intron-variant
rs10747759 -- 55,683,634(+) CTTCA(C/T)ATGCA intron-variant
rs111293312 -- 55,682,281(+) GGTGT(C/G)GGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for METTL7B Gene

Variant ID Type Subtype PubMed ID
nsv525231 CNV loss 19592680

Variation tolerance for METTL7B Gene

Residual Variation Intolerance Score: 81.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.63; 56.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for METTL7B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL7B Gene

Disorders for METTL7B Gene

Relevant External Links for METTL7B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for METTL7B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL7B Gene

Publications for METTL7B Gene

  1. Identification and characterization of associated with lipid droplet protein 1: A novel membrane-associated protein that resides on hepatic lipid droplets. (PMID: 17004324) TurrA^ S. … Pol A. (Traffic 2006) 2 3 64
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  5. Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation. (PMID: 21103663) Schaafhausen A. … MA1ller C.R. (Thromb. Haemost. 2011) 3 64

Products for METTL7B Gene

Sources for METTL7B Gene

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