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Aliases for METTL7B Gene

Aliases for METTL7B Gene

  • Methyltransferase Like 7B 2 3
  • Associated With Lipid Droplets 1 2 3
  • Methyltransferase-Like Protein 7B 3
  • EC 2.1.1.- 4
  • EC 2.1.1 64
  • ALDI 3

External Ids for METTL7B Gene

Summaries for METTL7B Gene

GeneCards Summary for METTL7B Gene

METTL7B (Methyltransferase Like 7B) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is METTL7A.

UniProtKB/Swiss-Prot for METTL7B Gene

  • Probable methyltransferase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL7B Gene

Genomics for METTL7B Gene

Genomic Location for METTL7B Gene

Start:
55,681,546 bp from pter
End:
55,684,611 bp from pter
Size:
3,066 bases
Orientation:
Plus strand

Genomic View for METTL7B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for METTL7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL7B Gene

Regulatory Elements for METTL7B Gene

Proteins for METTL7B Gene

  • Protein details for METTL7B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UX53-MET7B_HUMAN
    Recommended name:
    Methyltransferase-like protein 7B
    Protein Accession:
    Q6UX53
    Secondary Accessions:
    • A8K247
    • Q8WUI1

    Protein attributes for METTL7B Gene

    Size:
    244 amino acids
    Molecular mass:
    27775 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ88872.1; Type=Erroneous termination; Positions=245; Note=Translated as stop.; Evidence={ECO:0000305}; Sequence=BAF82801.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for METTL7B Gene

Proteomics data for METTL7B Gene at MOPED

Selected DME Specific Peptides for METTL7B Gene

Post-translational modifications for METTL7B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for METTL7B Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for METTL7B Gene

Protein Domains for METTL7B Gene

UniProtKB/Swiss-Prot:

MET7B_HUMAN
Family:
  • Belongs to the methyltransferase superfamily.:
    • Q6UX53
genes like me logo Genes that share domains with METTL7B: view

No data available for Gene Families for METTL7B Gene

Function for METTL7B Gene

Molecular function for METTL7B Gene

UniProtKB/Swiss-Prot Function: Probable methyltransferase.

Enzyme Numbers (IUBMB) for METTL7B Gene

Gene Ontology (GO) - Molecular Function for METTL7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity --
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity IBA --
genes like me logo Genes that share ontologies with METTL7B: view

Phenotypes for METTL7B Gene

GenomeRNAi human phenotypes for METTL7B:
genes like me logo Genes that share phenotypes with METTL7B: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for METTL7B Gene

Localization for METTL7B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for METTL7B Gene COMPARTMENTS Subcellular localization image for METTL7B gene
Compartment Confidence
extracellular 3
plasma membrane 2
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for METTL7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with METTL7B: view

Pathways for METTL7B Gene

SuperPathways for METTL7B Gene

No Data Available

Interacting Proteins for METTL7B Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000377796%0d%0a9606.ENSP00000378426%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000377796 for METTL7B Gene via STRING

Gene Ontology (GO) - Biological Process for METTL7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0032259 methylation IBA --
genes like me logo Genes that share ontologies with METTL7B: view

No data available for Pathways by source for METTL7B Gene

Transcripts for METTL7B Gene

mRNA/cDNA for METTL7B Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(85) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for METTL7B Gene

Methyltransferase like 7B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for METTL7B Gene

No ASD Table

Relevant External Links for METTL7B Gene

GeneLoc Exon Structure for
METTL7B
ECgene alternative splicing isoforms for
METTL7B

Expression for METTL7B Gene

mRNA expression in normal human tissues for METTL7B Gene

mRNA differential expression in normal tissues according to GTEx for METTL7B Gene

This gene is overexpressed in Heart - Atrial Appendage (18.0) and Liver (13.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for METTL7B Gene

SOURCE GeneReport for Unigene cluster for METTL7B Gene Hs.51483

genes like me logo Genes that share expressions with METTL7B: view

Orthologs for METTL7B Gene

This gene was present in the common ancestor of chordates.

Orthologs for METTL7B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL7B 36
  • 100 (n)
  • 100 (a)
METTL7B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia METTL7B 36
  • 86.07 (n)
  • 85.78 (a)
METTL7B 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia METTL7B 36
  • 89.09 (n)
  • 87.44 (a)
METTL7B 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mettl7b 36
  • 84.3 (n)
  • 83.41 (a)
Mettl7b 16
Mettl7b 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia METTL7B 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mettl7b 36
  • 83.11 (n)
  • 82.51 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 54 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 59 (a)
ManyToMany
-- 37
  • 48 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii mettl7a 37
  • 45 (a)
ManyToMany
si:ch211-173n18.3 37
  • 47 (a)
ManyToMany
si:ch211-173n18.4 37
  • 45 (a)
ManyToMany
Species with no ortholog for METTL7B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for METTL7B Gene

ENSEMBL:
Gene Tree for METTL7B (if available)
TreeFam:
Gene Tree for METTL7B (if available)

Paralogs for METTL7B Gene

Paralogs for METTL7B Gene

Selected SIMAP similar genes for METTL7B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with METTL7B: view

Variants for METTL7B Gene

Sequence variations from dbSNP and Humsavar for METTL7B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs3847674 -- 55,682,482(+) GGGAG(C/T)GGGGA intron-variant
rs3858537 -- 55,682,628(+) AAAAA(-/A)TACAA intron-variant
rs3892229 -- 55,682,425(+) CACAA(C/T)TGGGT intron-variant
rs4081809 -- 55,681,238(+) TACAC(A/C)TACTT upstream-variant-2KB
rs4759187 -- 55,681,479(+) CTGCC(C/T)CCCTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for METTL7B Gene

Variant ID Type Subtype PubMed ID
nsv525231 CNV Loss 19592680

Relevant External Links for METTL7B Gene

HapMap Linkage Disequilibrium report
METTL7B

Disorders for METTL7B Gene

No disorders were found for METTL7B Gene.

No data available for UniProtKB/Swiss-Prot for METTL7B Gene

Publications for METTL7B Gene

  1. Identification and characterization of associated with lipid droplet protein 1: A novel membrane-associated protein that resides on hepatic lipid droplets. (PMID: 17004324) TurrA^ S. … Pol A. (Traffic 2006) 2 3
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation. (PMID: 21103663) Schaafhausen A. … MA1ller C.R. (Thromb. Haemost. 2011) 3

Products for METTL7B Gene

Sources for METTL7B Gene

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