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Aliases for METTL7A Gene

Aliases for METTL7A Gene

  • Methyltransferase Like 7A 2 3 5
  • Protein AAM-B 3 4
  • Methyltransferase-Like Protein 7A 3
  • EC 2.1.1.- 4
  • EC 2.1.1 61
  • AAM-B 3

External Ids for METTL7A Gene

Previous GeneCards Identifiers for METTL7A Gene

  • GC12P049604
  • GC12P051318
  • GC12P048351

Summaries for METTL7A Gene

GeneCards Summary for METTL7A Gene

METTL7A (Methyltransferase Like 7A) is a Protein Coding gene. Among its related pathways are Innate Immune System. GO annotations related to this gene include methyltransferase activity and S-adenosylmethionine-dependent methyltransferase activity. An important paralog of this gene is METTL7B.

UniProtKB/Swiss-Prot for METTL7A Gene

  • Probable methyltransferase.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL7A Gene

Genomics for METTL7A Gene

Regulatory Elements for METTL7A Gene

Enhancers for METTL7A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G050930 1.9 FANTOM5 Ensembl ENCODE dbSUPER 4.8 +10.1 10089 5.1 HDGF FOXA2 PKNOX1 ARNT ARID4B DMAP1 YY1 ZNF766 FOS KLF13 SLC11A2 RNU6-1273P CSRNP2 METTL7A ENSG00000274156
GH12G051004 1 ENCODE dbSUPER 4.9 +82.2 82170 2.7 CTCF ESRRA SIN3A RBBP5 RAD21 ZKSCAN1 ZNF121 CTBP1 GATA3 ZFHX2 SLC11A2 CSRNP2 METTL7A RNU7-39P ENSG00000274797
GH12G051398 1.2 FANTOM5 Ensembl ENCODE 3.6 +476.8 476791 4.5 CTCF HLF CEBPB ZNF121 TCF12 JUND GLIS1 PRDM10 FOS EGR2 GALNT6 HIGD1C SCN8A SLC4A8 METTL7A ENSG00000271065
GH12G050921 1.6 FANTOM5 ENCODE dbSUPER 0.7 +2.0 2021 7.0 PKNOX1 MLX CREB3L1 ARNT SIN3A ARID4B FEZF1 DMAP1 ZNF2 YY1 SLC11A2 LETMD1 TFCP2 ENSG00000257298 LIMA1 HNRNPA3P10 RNU6-1273P CERS5 ATF1 LARP4
GH12G050929 0.7 ENCODE 0.4 +6.9 6926 1.0 CTCF HCFC1 CBFB NR2F1 BHLHE40 BACH1 GATAD2B DPF2 POLR2A EED SLC11A2 RNU6-1273P LETMD1 ENSG00000274156 METTL7A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around METTL7A on UCSC Golden Path with GeneCards custom track

Genomic Location for METTL7A Gene

Chromosome:
12
Start:
50,923,472 bp from pter
End:
50,932,517 bp from pter
Size:
9,046 bases
Orientation:
Plus strand

Genomic View for METTL7A Gene

Genes around METTL7A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL7A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL7A Gene

Proteins for METTL7A Gene

  • Protein details for METTL7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8H3-MET7A_HUMAN
    Recommended name:
    Methyltransferase-like protein 7A
    Protein Accession:
    Q9H8H3
    Secondary Accessions:
    • Q9H7R3
    • Q9UHZ7
    • Q9Y422

    Protein attributes for METTL7A Gene

    Size:
    244 amino acids
    Molecular mass:
    28319 Da
    Quaternary structure:
    • Self-associates.
    SequenceCaution:
    • Sequence=AAF20268.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for METTL7A Gene

Selected DME Specific Peptides for METTL7A Gene

Q9H8H3:
  • RVLRPGG
  • DVVVCTLVLCSV

Post-translational modifications for METTL7A Gene

  • Ubiquitination at posLast=3434
  • Modification sites at PhosphoSitePlus

Other Protein References for METTL7A Gene

Domains & Families for METTL7A Gene

Gene Families for METTL7A Gene

Protein Domains for METTL7A Gene

Suggested Antigen Peptide Sequences for METTL7A Gene

Graphical View of Domain Structure for InterPro Entry

Q9H8H3

UniProtKB/Swiss-Prot:

MET7A_HUMAN :
  • Belongs to the methyltransferase superfamily.
Family:
  • Belongs to the methyltransferase superfamily.
genes like me logo Genes that share domains with METTL7A: view

Function for METTL7A Gene

Molecular function for METTL7A Gene

UniProtKB/Swiss-Prot Function:
Probable methyltransferase.

Enzyme Numbers (IUBMB) for METTL7A Gene

Gene Ontology (GO) - Molecular Function for METTL7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with METTL7A: view
genes like me logo Genes that share phenotypes with METTL7A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for METTL7A

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL7A Gene

Localization for METTL7A Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL7A Gene

Lipid droplet. Endoplasmic reticulum. Membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL7A gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
plasma membrane 3
mitochondrion 1
peroxisome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for METTL7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005783 endoplasmic reticulum IEA --
GO:0005811 lipid particle IEA,IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with METTL7A: view

Pathways & Interactions for METTL7A Gene

genes like me logo Genes that share pathways with METTL7A: view

Pathways by source for METTL7A Gene

3 Reactome pathways for METTL7A Gene

Interacting Proteins for METTL7A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000331787%0d%0a9606.ENSP00000309036%0d%0a
Selected Interacting proteins: Q9H8H3-MET7A_HUMAN ENSP00000331787 for METTL7A Gene via IID STRING

Gene Ontology (GO) - Biological Process for METTL7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0032259 methylation IEA --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with METTL7A: view

No data available for SIGNOR curated interactions for METTL7A Gene

Drugs & Compounds for METTL7A Gene

No Compound Related Data Available

Transcripts for METTL7A Gene

Unigene Clusters for METTL7A Gene

Methyltransferase like 7A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL7A Gene

No ASD Table

Relevant External Links for METTL7A Gene

GeneLoc Exon Structure for
METTL7A
ECgene alternative splicing isoforms for
METTL7A

Expression for METTL7A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for METTL7A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for METTL7A Gene

This gene is overexpressed in Nasal epithelium (12.2) and Liver (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for METTL7A Gene



Protein tissue co-expression partners for METTL7A Gene

NURSA nuclear receptor signaling pathways regulating expression of METTL7A Gene:

METTL7A

SOURCE GeneReport for Unigene cluster for METTL7A Gene:

Hs.744021

Evidence on tissue expression from TISSUES for METTL7A Gene

  • Liver(4.6)
  • Thyroid gland(4.4)
  • Pancreas(4.3)
  • Nervous system(3.8)
  • Kidney(2.8)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with METTL7A: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL7A Gene

Orthologs for METTL7A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METTL7A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL7A 34 35
  • 99.04 (n)
cow
(Bos Taurus)
Mammalia METTL7A 34 35
  • 87.7 (n)
-- 35
  • 80 (a)
OneToMany
dog
(Canis familiaris)
Mammalia METTL7A 35 34
  • 84.58 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Mettl7a1 34 16 35
  • 83.61 (n)
Mettl7a2 35
  • 79 (a)
OneToMany
Mettl7a3 35
  • 78 (a)
OneToMany
AB099516 35
  • 53 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mettl7a 34
  • 83.61 (n)
chicken
(Gallus gallus)
Aves METTL7A 34
  • 65.15 (n)
-- 35
  • 60 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 63 (a)
ManyToMany
-- 35
  • 59 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl7a 34
  • 63.25 (n)
Str.4191 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.20056 34
zebrafish
(Danio rerio)
Actinopterygii si:ch211-173n18.3 34 35
  • 58.94 (n)
si:ch211-173n18.4 35
  • 52 (a)
ManyToMany
mettl7a 35
  • 51 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G69523 34
  • 51.32 (n)
rice
(Oryza sativa)
Liliopsida Os02g0744100 34
  • 49.35 (n)
Species where no ortholog for METTL7A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for METTL7A Gene

ENSEMBL:
Gene Tree for METTL7A (if available)
TreeFam:
Gene Tree for METTL7A (if available)

Paralogs for METTL7A Gene

Paralogs for METTL7A Gene

(1) SIMAP similar genes for METTL7A Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for METTL7A Gene

genes like me logo Genes that share paralogs with METTL7A: view

Variants for METTL7A Gene

Sequence variations from dbSNP and Humsavar for METTL7A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1001066648 -- 50,928,516(+) CCAGC(A/G)TGCAT intron-variant
rs1001274023 -- 50,930,434(+) ACCAC(C/G)ATGCC utr-variant-3-prime
rs1001405059 -- 50,930,217(+) AAATG(C/T)TAAGT utr-variant-3-prime
rs1001457539 -- 50,929,817(+) CAGGT(C/T)TGCAA intron-variant
rs1001503330 -- 50,923,837(+) CAACA(A/G)AAAGA upstream-variant-2KB, utr-variant-5-prime

Variation tolerance for METTL7A Gene

Residual Variation Intolerance Score: 34.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.45; 54.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for METTL7A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
METTL7A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for METTL7A Gene

Disorders for METTL7A Gene

Relevant External Links for METTL7A

Genetic Association Database (GAD)
METTL7A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
METTL7A

No disorders were found for METTL7A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL7A Gene

Publications for METTL7A Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. AAM-B Interacts with Nonstructural 4B and Regulates Hepatitis C Virus Propagation. (PMID: 26185986) Park E.M. … Hwang S.B. (PLoS ONE 2015) 3 64

Products for METTL7A Gene

Sources for METTL7A Gene

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