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Aliases for METTL7A Gene

Aliases for METTL7A Gene

  • Methyltransferase Like 7A 2 3 5
  • Protein AAM-B 3 4
  • EC 2.1.1.- 4
  • EC 2.1.1 63
  • AAM-B 3

External Ids for METTL7A Gene

Previous GeneCards Identifiers for METTL7A Gene

  • GC12P049604
  • GC12P051318
  • GC12P048351

Summaries for METTL7A Gene

GeneCards Summary for METTL7A Gene

METTL7A (Methyltransferase Like 7A) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity and S-adenosylmethionine-dependent methyltransferase activity. An important paralog of this gene is METTL7B.

UniProtKB/Swiss-Prot for METTL7A Gene

  • Probable methyltransferase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL7A Gene

Genomics for METTL7A Gene

Regulatory Elements for METTL7A Gene

Genomic Location for METTL7A Gene

Chromosome:
12
Start:
50,923,472 bp from pter
End:
50,932,517 bp from pter
Size:
9,046 bases
Orientation:
Plus strand

Genomic View for METTL7A Gene

Genes around METTL7A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL7A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL7A Gene

Proteins for METTL7A Gene

  • Protein details for METTL7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8H3-MET7A_HUMAN
    Recommended name:
    Methyltransferase-like protein 7A
    Protein Accession:
    Q9H8H3
    Secondary Accessions:
    • Q9H7R3
    • Q9UHZ7
    • Q9Y422

    Protein attributes for METTL7A Gene

    Size:
    244 amino acids
    Molecular mass:
    28319 Da
    Quaternary structure:
    • Self-associates.
    SequenceCaution:
    • Sequence=AAF20268.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for METTL7A Gene

Proteomics data for METTL7A Gene at MOPED

Selected DME Specific Peptides for METTL7A Gene

Post-translational modifications for METTL7A Gene

  • Ubiquitination at Lys 34
  • Modification sites at PhosphoSitePlus

Other Protein References for METTL7A Gene

Antibody Products

Domains & Families for METTL7A Gene

Gene Families for METTL7A Gene

Protein Domains for METTL7A Gene

Suggested Antigen Peptide Sequences for METTL7A Gene

Graphical View of Domain Structure for InterPro Entry

Q9H8H3

UniProtKB/Swiss-Prot:

MET7A_HUMAN :
  • Belongs to the methyltransferase superfamily.
Family:
  • Belongs to the methyltransferase superfamily.
genes like me logo Genes that share domains with METTL7A: view

Function for METTL7A Gene

Molecular function for METTL7A Gene

UniProtKB/Swiss-Prot Function:
Probable methyltransferase.

Enzyme Numbers (IUBMB) for METTL7A Gene

genes like me logo Genes that share phenotypes with METTL7A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for METTL7A

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL7A Gene

Localization for METTL7A Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL7A Gene

Lipid droplet. Endoplasmic reticulum. Membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for METTL7A Gene COMPARTMENTS Subcellular localization image for METTL7A gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
plasma membrane 3
cytosol 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for METTL7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with METTL7A: view

Pathways & Interactions for METTL7A Gene

SuperPathways for METTL7A Gene

No Data Available

Interacting Proteins for METTL7A Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000331787%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: Q9H8H3-MET7A_HUMAN ENSP00000331787 for METTL7A Gene via I2D STRING

Gene Ontology (GO) - Biological Process for METTL7A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for METTL7A Gene

Drugs & Compounds for METTL7A Gene

No Compound Related Data Available

Transcripts for METTL7A Gene

Unigene Clusters for METTL7A Gene

Methyltransferase like 7A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL7A Gene

No ASD Table

Relevant External Links for METTL7A Gene

GeneLoc Exon Structure for
METTL7A
ECgene alternative splicing isoforms for
METTL7A

Expression for METTL7A Gene

mRNA expression in normal human tissues for METTL7A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for METTL7A Gene

This gene is overexpressed in Nasal epithelium (12.2) and Liver (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for METTL7A Gene



SOURCE GeneReport for Unigene cluster for METTL7A Gene Hs.744021

genes like me logo Genes that share expression patterns with METTL7A: view

Protein tissue co-expression partners for METTL7A Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for METTL7A Gene

Orthologs for METTL7A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METTL7A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia METTL7A 35
  • 87.7 (n)
  • 86.48 (a)
-- 36
  • 80 (a)
OneToMany
METTL7A 36
  • 86 (a)
OneToMany
dog
(Canis familiaris)
Mammalia METTL7A 35
  • 84.58 (n)
  • 83.7 (a)
METTL7A 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mettl7a1 35
  • 83.61 (n)
  • 84.84 (a)
Mettl7a1 16
AB099516 36
  • 53 (a)
OneToMany
Mettl7a1 36
  • 83 (a)
OneToMany
Mettl7a2 36
  • 79 (a)
OneToMany
Mettl7a3 36
  • 78 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia METTL7A 35
  • 99.04 (n)
  • 98.77 (a)
METTL7A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mettl7a 35
  • 83.61 (n)
  • 85.66 (a)
chicken
(Gallus gallus)
Aves METTL7A 35
  • 65.15 (n)
  • 61.16 (a)
-- 36
  • 60 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 63 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl7a 35
  • 63.25 (n)
  • 60.66 (a)
Str.4191 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.20056 35
zebrafish
(Danio rerio)
Actinopterygii si:ch211-173n18.3 35
  • 58.94 (n)
  • 54.94 (a)
mettl7a 36
  • 51 (a)
ManyToMany
si:ch211-173n18.3 36
  • 53 (a)
ManyToMany
si:ch211-173n18.4 36
  • 52 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G69523 35
  • 51.32 (n)
  • 42.86 (a)
rice
(Oryza sativa)
Liliopsida Os02g0744100 35
  • 49.35 (n)
  • 38.73 (a)
Species with no ortholog for METTL7A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for METTL7A Gene

ENSEMBL:
Gene Tree for METTL7A (if available)
TreeFam:
Gene Tree for METTL7A (if available)

Paralogs for METTL7A Gene

Paralogs for METTL7A Gene

(1) SIMAP similar genes for METTL7A Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for METTL7A Gene

genes like me logo Genes that share paralogs with METTL7A: view

Variants for METTL7A Gene

Sequence variations from dbSNP and Humsavar for METTL7A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs28372674 - 50,925,438(-) ATCAG(C/T)CACCT reference, missense
rs319940 -- 50,931,515(-) tggcc(A/T)ggctg utr-variant-3-prime
rs319941 -- 50,931,646(-) gcaac(A/C)ttcgc utr-variant-3-prime
rs319942 -- 50,932,222(-) TTGCT(C/T)GATGT utr-variant-3-prime
rs1053450 -- 50,932,375(+) GGTTA(A/G)AGGGT utr-variant-3-prime

Variation tolerance for METTL7A Gene

Residual Variation Intolerance Score: 34.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.45; 54.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for METTL7A Gene

HapMap Linkage Disequilibrium report
METTL7A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for METTL7A Gene

Disorders for METTL7A Gene

Relevant External Links for METTL7A

Genetic Association Database (GAD)
METTL7A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
METTL7A

No disorders were found for METTL7A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL7A Gene

Publications for METTL7A Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for METTL7A Gene

Sources for METTL7A Gene

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