METTL7A Gene
protein-coding GIFtS : 48
GCID: GC12 P051318
methyltransferase like 7A
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Aliasesfor METTL7A gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Methyltransferase Like 7A 1 2 Methyltransferase-Like Protein 7A2 Protein AAM-B2 3 EC 2.1.1.-3 DKFZP586A05221 EC 2.1.18 AAM-B2
Export aliases for METTL7A gene to outside databases Previous GC identifers: GC12P049604 GC12P048351
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Summariesfor METTL7A gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: MET7A_HUMAN, Q9H8H3 Function : Probable methyltransferase (By similarity)
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Genomic Viewsfor METTL7A gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000012.11 NC_018923.1 NT_029419.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the METTL7A gene promoter: Pbx1a Lmo2 E47 CREB deltaCREB SEF-1 (1) Hand1 ZIC2/Zic2 MRF-2 c-Myc Other transcription factors Search SABiosciences Chromatin IP Primers for METTL7A Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL7A
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 12q13.12 Ensembl cytogenetic band: 12q13.12 HGNC cytogenetic band: 12q13.12 METTL7A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12P051318: view genomic region
(about GC identifiers )
Start:
51,317,255 bp from pter
End:
51,326,300 bp from pter
Size:
9,046 bases
Orientation:
plus strand
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Proteinsfor METTL7A gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: MET7A_HUMAN, Q9H8H3 (See
protein sequence )Recommended Name: Methyltransferase-like protein 7A precursor Size : 244 amino acids; 28319 Da
Subunit : Self-associates
Subcellular location : Lipid droplet. Endoplasmic reticulum. Membrane
Sequence caution : Sequence=AAF20268.1; Type=Erroneous initiation;
Secondary accessions : Q9H7R3 Q9UHZ7 Q9Y422Explore the universe of human proteins at neXtProt for METTL7A: NX_Q9H8H3 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9H8H3 2 DME Specific Peptides for METTL7A (Q9H8H3 ) METTL7A Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_054752.3 ENSEMBL proteins: ENSP00000448785 ENSP00000450239 ENSP00000447542 ENSP00000447184 ENSP00000448286 ENSP00000331787 Human Recombinant Protein Products: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
METTL7A for ontologies About GeneDecksing METTL7A Antibody Products: Assay Products for METTL7A:
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Protein
Domains / Familiesfor METTL7A gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
METTL7A for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q9H8H3 ProtoNet protein and cluster: Q9H8H3
1 Blocks protein family : IPB013216 Methyltransferase type 11 UniProtKB/Swiss-Prot: MET7A_HUMAN, Q9H8H3 Similarity : Belongs to the methyltransferase superfamily
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Functionfor METTL7A gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: MET7A_HUMAN, Q9H8H3 Function : Probable methyltransferase (By similarity)Enzyme Numbers (IUBMB): EC 2.1.1.- 1 EC 2.1.1 2
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for METTL7A (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for METTL7AOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: METTL7A (NM_014033 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for METTL7A Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat METTL7A
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL7A
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0008168 methyltransferase activity
IEA --
METTL7A for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for METTL7A :Animal Models: Mouse knock-out Mettl7a1 tm1Lex for METTL7A 1 MGI phenotypic allele for Mettl7a1 (no phenotypes)
METTL7A for phenotypes About GeneDecksing
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Pathways & Interactionsfor METTL7A gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for METTL7A STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)3 Interacting proteins for METTL7A (Q9H8H3 3 ENSP00000331787 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor METTL7A gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for METTL7A Search CenterWatch for drugs/clinical trials and news about METTL7A / MET7A
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Transcriptsfor METTL7A gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for METTL7A gene: NM_014033.3 Unigene Cluster for METTL7A:
Methyltransferase like 7A Hs.744021 [show with all ESTs ] Unigene Representative Sequence: NM_014033 6 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000548553 ENST00000550502 ENST00000547104 ENST00000546513 (uc010smv.1 )ENST00000550097 ENST00000332160 (uc001rxb.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for METTL7A (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for METTL7AOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: METTL7A (NM_014033 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for METTL7A Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat METTL7A
Additional cDNA sequence: AF113007.1 AJ536233.1 AK023693.1 AK024409.1 AK024905.1 AK130665.1 AK225595.1 AK225689.1 AK293356.1 AK307071.1 AL050159.1 AY358797.1 BC004492.2 BC008180.2
12 DOTS entries : DT.86993756 DT.95310103
DT.92324829 DT.452960 DT.121126720 DT.121126718 DT.101986390 DT.100820837 DT.100685758 DT.95310101 DT.100645716 DT.100814012 24/186 AceView cDNA sequences (see all 186 ):
H57685 BM808678 AI248588 BP376025 N76125 BQ185697 CA313463 Z42168 CA434650 H81430 AK023693 BP334592 BQ437637 CR612149 AI097392 AW328039 AU139674 R83371 AI589115 AI278631 AA237076 BP358296 BQ188253 CB118170 GeneLoc Exon Structure
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Expression for METTL7A gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section METTL7A expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image METTL7A expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category CyT49 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See METTL7A Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for METTL7A SOURCE GeneReport for Unigene cluster: Hs.744021 SABiosciences Custom PCR Arrays for METTL7A Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for METTL7ABrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat METTL7A QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat METTL7A QIAGEN QuantiFast Probe-based Assays in human , mouse , rat METTL7A In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL7A
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Orthologsfor METTL7A gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for METTL7A gene from 6/17 species (see all 17 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
METTL7A1
methyltransferase like 7A
65.15(n) 61.16(a)
 
426871 XM_424479.3 XP_424479.2
lizard (Anolis carolinensis)
Reptilia
--
--
59(a)
1 ↔ 1
2(90974318-90981416)
African clawed frog (Xenopus laevis)
Amphibia
Xl.200562
Xenopus laevis transcribed sequence with weak similarity more
71.19(n)
 
BJ097144.1
zebrafish (Danio rerio)
Actinopterygii
LOC5690891
methyltransferase-like protein 7A-like
58.94(n) 54.94(a)
 
569089 XM_692453.2 XP_697545.2
thale cress (Arabidopsis thaliana)
eudicotyledons
AT1G695231
S-adenosylmethionine-dependent methyltransferase domain-containing more
52.54(n) 44.57(a)
 
843286 NM_105620.3 NP_564969.1
rice (Oryza sativa)
Liliopsida
Os02g07441001
hypothetical protein
48.46(n) 38.54(a)
 
4330705 NM_001054635.1 NP_001048100.1
ENSEMBL Gene Tree for METTL7A (if available)TreeFam Gene Tree for METTL7A (if available)
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Paralogsfor METTL7A gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for METTL7A gene METTL7B 2 1 SIMAP similar gene for METTL7A using alignment to 3 protein entries: MET7A_HUMAN (see all proteins ):METTL7B
METTL7A for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for METTL7A PGOHUM00000261131
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Genomic Variantsfor METTL7A gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 12 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for METTL7A (51317255 - 51326300 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for METTL7A: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing METTL7A
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Disorders
/ Diseasesfor METTL7A gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
METTL7A for disorders About GeneDecksing 2 diseases for METTL7A : About MalaCards tuberculosis mycobacterium tuberculosis Export disorders for METTL7A gene to outside databases
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Publicationsfor METTL7A gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for METTL7A gene, integrated from 9 sources (see all 17 ): (articles sorted by number of sources associating them with METTL7A) Utopia : connect your pdf to the dynamic world of online information
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309) 1 , 2 , 3 Clark H.F.... Gray A.M. (2003) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473) 1 Wagner S.A....Choudhary C. (2011) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011) Targeting sequences of UBXD8 and AAM-B reveal that the ER has a direct role in the emergence and regression of lipid droplets. (PubMed id 19773358) 2 Zehmer J.K.... Anderson R.G.W. (2009) Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201) 1 Abdelmohsen K....Gorospe M. (2009) Identification of a novel N-terminal hydrophobic sequence that targets proteins to lipid droplets. (PubMed id 18477614) 2 Zehmer J.K.... Anderson R.G.W. (2008)
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External Searches for METTL7A gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing METTL7A gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing METTL7A gene
(According to HUGE )
About This Section --
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Specialized Databases showing METTL7A gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for METTL7A Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for METTL7A gene: Search GeneIP for patents involving METTL7A GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor METTL7A gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for METTL7A OriGene shRNA RFP for METTL7A OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for METTL7A OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for METTL7A OriGene Protein Over-expression Lysate for METTL7A Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for METTL7A OriGene 3'-UTR Clone for METTL7A OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for METTL7A OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for METTL7A Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for METTL7A OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for METTL7A OriGene Custom Protein Services for METTL7A OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat METTL7A QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing METTL7A QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL7A QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat METTL7A QIAGEN QuantiFast Probe-based Assays in human , mouse , rat METTL7A QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat METTL7A
Search Tocris compounds for METTL7A
METTL7A Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL7A
ThermoFisher Antibodies for METTL7A
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat METTL7A
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