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Aliases for METTL6 Gene

Aliases for METTL6 Gene

  • Methyltransferase Like 6 2 3
  • EC 2.1.1.41 64
  • EC 2.1.1.- 4
  • EC 2.1.1 64

External Ids for METTL6 Gene

Summaries for METTL6 Gene

GeneCards Summary for METTL6 Gene

METTL6 (Methyltransferase Like 6) is a Protein Coding gene. Among its related pathways are Phenylalanine metabolism and Histidine metabolism. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is METTL8.

UniProtKB/Swiss-Prot for METTL6 Gene

  • Probable methyltransferase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL6 Gene

Genomics for METTL6 Gene

Genomic Location for METTL6 Gene

Start:
15,381,275 bp from pter
End:
15,440,566 bp from pter
Size:
59,292 bases
Orientation:
Minus strand

Genomic View for METTL6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for METTL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL6 Gene

Regulatory Elements for METTL6 Gene

Proteins for METTL6 Gene

  • Protein details for METTL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCB7-METL6_HUMAN
    Recommended name:
    Methyltransferase-like protein 6
    Protein Accession:
    Q8TCB7
    Secondary Accessions:
    • Q96LU4

    Protein attributes for METTL6 Gene

    Size:
    284 amino acids
    Molecular mass:
    33251 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH22400.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for METTL6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for METTL6 Gene

Proteomics data for METTL6 Gene at MOPED

Selected DME Specific Peptides for METTL6 Gene

Post-translational modifications for METTL6 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys120

Domains for METTL6 Gene

Protein Domains for METTL6 Gene

UniProtKB/Swiss-Prot:

METL6_HUMAN
Family:
  • Belongs to the methyltransferase superfamily. METL family.:
    • Q8TCB7
genes like me logo Genes that share domains with METTL6: view

No data available for Gene Families for METTL6 Gene

Function for METTL6 Gene

Molecular function for METTL6 Gene

UniProtKB/Swiss-Prot Function: Probable methyltransferase.

Enzyme Numbers (IUBMB) for METTL6 Gene

Gene Ontology (GO) - Molecular Function for METTL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with METTL6: view

Phenotypes for METTL6 Gene

GenomeRNAi human phenotypes for METTL6:
genes like me logo Genes that share phenotypes with METTL6: view

miRNA for METTL6 Gene

miRTarBase miRNAs that target METTL6

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for METTL6 Gene

Localization for METTL6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for METTL6 Gene COMPARTMENTS Subcellular localization image for METTL6 gene
Compartment Confidence
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for METTL6 Gene

Pathways for METTL6 Gene

genes like me logo Genes that share pathways with METTL6: view

Pathways by source for METTL6 Gene

2 KEGG pathways for METTL6 Gene

Interacting Proteins for METTL6 Gene

Gene Ontology (GO) - Biological Process for METTL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL6: view

Transcripts for METTL6 Gene

Unigene Clusters for METTL6 Gene

Methyltransferase like 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for METTL6 Gene

No ASD Table

Relevant External Links for METTL6 Gene

GeneLoc Exon Structure for
METTL6
ECgene alternative splicing isoforms for
METTL6

Expression for METTL6 Gene

mRNA expression in normal human tissues for METTL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for METTL6 Gene

SOURCE GeneReport for Unigene cluster for METTL6 Gene Hs.149487

genes like me logo Genes that share expressions with METTL6: view

Orthologs for METTL6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METTL6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL6 36
  • 99.53 (n)
  • 99.3 (a)
METTL6 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia METTL6 36
  • 90.14 (n)
  • 90.49 (a)
METTL6 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 93 (a)
OneToMany
-- 37
  • 84 (a)
OneToMany
METTL6 36
  • 91 (n)
  • 93.43 (a)
mouse
(Mus musculus)
Mammalia Mettl6 36
  • 86.59 (n)
  • 88.04 (a)
Mettl6 16
Mettl6 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia METTL6 37
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia METTL6 37
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mettl6 36
  • 85.44 (n)
  • 86.64 (a)
chicken
(Gallus gallus)
Aves METTL6 36
  • 80.22 (n)
  • 81.72 (a)
METTL6 37
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia METTL6 37
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl6 36
  • 72.51 (n)
  • 77.99 (a)
Str.6152 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1367 36
zebrafish
(Danio rerio)
Actinopterygii mettl6 36
  • 71.07 (n)
  • 73.21 (a)
mettl6 37
  • 68 (a)
OneToOne
zgc56175 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009818 36
  • 56.11 (n)
  • 55.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34195 36
  • 58.07 (n)
  • 58.59 (a)
CG34195 37
  • 51 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK1058.5 36
  • 53.6 (n)
  • 46 (a)
ZK1058.5 37
  • 41 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ABP140 37
  • 15 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G26200 36
  • 53.22 (n)
  • 46.91 (a)
rice
(Oryza sativa)
Liliopsida Os03g0143000 36
  • 55.49 (n)
  • 51.5 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC3H7.11 36
  • 50 (n)
  • 43.7 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3599 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 55 (a)
OneToOne
Species with no ortholog for METTL6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL6 Gene

ENSEMBL:
Gene Tree for METTL6 (if available)
TreeFam:
Gene Tree for METTL6 (if available)

Paralogs for METTL6 Gene

Paralogs for METTL6 Gene

Selected SIMAP similar genes for METTL6 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with METTL6: view

Variants for METTL6 Gene

Sequence variations from dbSNP and Humsavar for METTL6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs749845 -- 15,422,811(+) cttaa(C/T)cctgt intron-variant
rs905641 -- 15,401,557(-) CTTTC(C/T)TTTTT intron-variant
rs1051610 -- 15,410,182(-) CTACT(A/G/T)TGTAC utr-variant-3-prime, intron-variant
rs1131813 -- 15,410,395(-) gcagt(A/G)ggtcg utr-variant-3-prime, intron-variant
rs1869851 -- 15,415,442(-) tggtg(G/T)ttcat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for METTL6 Gene

Variant ID Type Subtype PubMed ID
nsv834621 CNV Gain 17160897
nsv834622 CNV Gain 17160897

Relevant External Links for METTL6 Gene

HapMap Linkage Disequilibrium report
METTL6

Disorders for METTL6 Gene

No disorders were found for METTL6 Gene.

No data available for UniProtKB/Swiss-Prot for METTL6 Gene

Publications for METTL6 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order amish. (PMID: 18759275) McArdle P.F. … Shuldiner A.R. (Arthritis Rheum. 2008) 3
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for METTL6 Gene

Sources for METTL6 Gene

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