METTL6 Gene
protein-coding GIFtS: 45
GCID: GC03M015422
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|
methyltransferase like 6
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Aliases
for METTL6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Methyltransferase Like 61 2 | | MGC241321 | | Methyltransferase-Like Protein 62 | | EC 2.1.1.-3 | | EC 2.1.18 | | EC 2.1.1.418 |
Export aliases for METTL6 gene to outside databasesPrevious GC identifers: GC03M015428 GC03M015386 |
Summaries
for METTL6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: METL6_HUMAN, Q8TCB7Function: Probable methyltransferase (By similarity)
|
Genomic Views
for METTL6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the METTL6 gene promoter:
TBP SREBP-1c SREBP-1b C/EBPalpha AREB6 SREBP-1a POU2F1 POU2F1a FOXO4 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for METTL6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p25.1 Ensembl cytogenetic band: 3p25.1 HGNC cytogenetic band: 3p25.1METTL6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M015422: view genomic region
(about GC identifiers)
Start:
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15,422,782 bp from pter |
End:
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15,469,047 bp from pter |
Size:
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46,266 bases |
Orientation:
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minus strand |
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Proteins
for METTL6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: METL6_HUMAN, Q8TCB7 (See
protein sequence)Recommended Name: Methyltransferase-like protein 6 Size: 284 amino acids; 33251 Da
Sequence caution: Sequence=AAH22400.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence;
Secondary accessions: Q96LU4Alternative splicing: 2 isoforms: Q8TCB7-1 Q8TCB7-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for METTL6: NX_Q8TCB7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TCB7
4/5 DME Specific Peptides for METTL6 (Q8TCB7) (see all 5)
METTL6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689609.2
ENSEMBL proteins: ENSP00000407613 ENSP00000400885 ENSP00000373300 ENSP00000410726 ENSP00000412006 ENSP00000373299
Human Recombinant Protein Products:
METTL6 Antibody Products:
Assay Products for METTL6: |
Protein
Domains /
Families
for METTL6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
METTL6 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8TCB7ProtoNet protein and cluster: Q8TCB7 UniProtKB/Swiss-Prot: METL6_HUMAN, Q8TCB7Similarity: Belongs to the methyltransferase superfamily. METL family |
Function
for METTL6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: METL6_HUMAN, Q8TCB7Function: Probable methyltransferase (By similarity)Enzyme Numbers (IUBMB): EC 2.1.1.-1 EC 2.1.12 EC 2.1.1.412
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: METTL6 (NM_152396) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for METTL6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL6 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008168 | methyltransferase activity |
IEA | -- |
METTL6 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for METTL6:
Animal Models:
1 MGI phenotypic allele  for Mettl6 (no phenotypes)
METTL6 for phenotypes About GeneDecksing
|
Pathways & Interactions
for METTL6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Tyrosine metabolism | | | 2 | Histidine metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Kegg Pathways (Kegg details for METTL6):
METTL6 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for METTL6
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/6 Interacting proteins for METTL6 (ENSP000003733004) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
|
Drugs & Compounds
for METTL6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for METTL6
Search CenterWatch for drugs/clinical trials and news about METTL6 / METL6
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Transcripts
for METTL6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for METTL6 gene: NM_152396.2 Unigene Cluster for METTL6: Methyltransferase like 6 Hs.149487 [show with all ESTs]Unigene Representative Sequence: BC0366879 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000443029 ENST00000584799 ENST00000458728 ENST00000383790(uc003bzs.1)
ENST00000450816(uc011avp.1) ENST00000489881 ENST00000485131 ENST00000453819
ENST00000383789(uc003bzt.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: METTL6 (NM_152396) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for METTL6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL6 |
Additional cDNA sequence: AK027185.1 AK057791.1 AK293370.1 BC022400.1 BC036687.1 7 DOTS entries: DT.97843612 DT.40230392 DT.97815259 DT.117685 DT.100793977 DT.97792161 DT.91749184 24/96 AceView cDNA sequences (see all 96): BU183521 AA890099 CR612029 BM983888 AI806529 CA430635 BU690093 Z44406 BQ023020 AA411950 AA411949 AI805298 BX114702 T89288 BE731411 BE889042 AI280022 BF345171 BG700872 CA414178 BM926809 BE733338 AA399581 BQ358414
GeneLoc Exon Structure
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Expression
for METTL6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| METTL6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See METTL6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for METTL6
SOURCE GeneReport for Unigene cluster: Hs.149487
SABiosciences Custom PCR Arrays for METTL6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for METTL6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat METTL6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL6 |
Orthologs
for METTL6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for METTL6 gene from 9/30 species (see all 30) About this table
ENSEMBL Gene Tree for METTL6 (if available)
TreeFam Gene Tree for METTL6 (if available) |
Paralogs
for METTL6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for METTL6 gene
- METTL2B2 METTL2A2 METTL82
2 SIMAP similar genes for METTL6 using alignment to 5 protein entries: METL6_HUMAN (see all proteins):METTL2B METTL8
METTL6 for paralogs About GeneDecksing
|
Genomic Variants
for METTL6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for METTL6 (15422782 - 15469047 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for METTL6: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for METTL6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
METTL6 for disorders About GeneDecksing
1  disease for METTL6: About MalaCardsmalaria
Export disorders for METTL6 gene to outside databases
|
Publications
for METTL6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for METTL6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with METTL6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
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External Searches for METTL6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing METTL6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing METTL6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing METTL6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for METTL6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for METTL6 gene:
Search GeneIP for patents involving METTL6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for METTL6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for METTL6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for METTL6 | | | OriGene Protein Over-expression Lysate for METTL6 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for METTL6 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for METTL6 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for METTL6 | | OriGene Custom Protein Services for METTL6 | | | OriGene Custom Immunoassay Development | | |
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 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat METTL6 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing METTL6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat METTL6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL6 |
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 |  |  |  | |
| | | | Search Tocris compounds for METTL6 |
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 | | | METTL6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL6 |
|  |  |  | | | | Search ThermoFisher Antibodies for METTL6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL6 |
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