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Aliases for METTL6 Gene

Aliases for METTL6 Gene

  • Methyltransferase Like 6 2 3 5
  • EC 2.1.1.41 61
  • EC 2.1.1.- 4
  • EC 2.1.1 61

External Ids for METTL6 Gene

Previous GeneCards Identifiers for METTL6 Gene

  • GC03M015428
  • GC03M015386

Summaries for METTL6 Gene

GeneCards Summary for METTL6 Gene

METTL6 (Methyltransferase Like 6) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is METTL2B.

UniProtKB/Swiss-Prot for METTL6 Gene

  • Probable methyltransferase.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL6 Gene

Genomics for METTL6 Gene

Regulatory Elements for METTL6 Gene

Enhancers for METTL6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G015426 1.3 ENCODE dbSUPER 13.4 +12.4 12395 2.8 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 METTL6 EAF1 RNU6-1024P GC03M015433
GH03G015499 1.1 FANTOM5 ENCODE dbSUPER 13.8 -59.2 -59216 1.2 CEBPB KDM1A ZIC2 TBX21 EAF1 COLQ METTL6 RNU6-1024P CAPN7 EAF1-AS1 COL6A4P1 HACL1 ANKRD28 SH3BP5
GH03G014946 1.4 Ensembl ENCODE 10.7 +492.0 491990 4.7 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF766 CAPN7 FGD5-AS1 SH3BP5-AS1 METTL6 MRPS25 RBSN RPS3AP53 PIR42856
GH03G014809 1.3 Ensembl ENCODE dbSUPER 10.7 +629.2 629238 2.8 BCOR ZNF146 ZBTB21 SUZ12 ZSCAN4 ZNF140 ZMYM3 ZNF266 ZNF384 RBBP5 METTL6 LINC02011 FGD5
GH03G015262 1 dbSUPER 12 +175.5 175519 4.4 HDGF ATF1 PKNOX1 ARNT SIN3A YY1 TCF12 ZNF766 GATA2 ELK1 SH3BP5-AS1 RNU6-454P SH3BP5 EAF1 METTL6 COL6A4P1 CAPN7 EAF1-AS1 RNU6-1024P RPS24P10
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around METTL6 on UCSC Golden Path with GeneCards custom track

Genomic Location for METTL6 Gene

Chromosome:
3
Start:
15,381,063 bp from pter
End:
15,440,566 bp from pter
Size:
59,504 bases
Orientation:
Minus strand

Genomic View for METTL6 Gene

Genes around METTL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL6 Gene

Proteins for METTL6 Gene

  • Protein details for METTL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCB7-METL6_HUMAN
    Recommended name:
    Methyltransferase-like protein 6
    Protein Accession:
    Q8TCB7
    Secondary Accessions:
    • Q96LU4

    Protein attributes for METTL6 Gene

    Size:
    284 amino acids
    Molecular mass:
    33251 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH22400.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for METTL6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for METTL6 Gene

Selected DME Specific Peptides for METTL6 Gene

Q8TCB7:
  • SKLGENFYVRQDGTRSYFFTD
  • FFKDRHW
  • CDFSPRA
  • YKVLKPG
  • LIFVLSA

Post-translational modifications for METTL6 Gene

  • Ubiquitination at posLast=120120
  • Modification sites at PhosphoSitePlus

Domains & Families for METTL6 Gene

Gene Families for METTL6 Gene

Protein Domains for METTL6 Gene

Suggested Antigen Peptide Sequences for METTL6 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TCB7

UniProtKB/Swiss-Prot:

METL6_HUMAN :
  • Belongs to the methyltransferase superfamily. METL family.
Family:
  • Belongs to the methyltransferase superfamily. METL family.
genes like me logo Genes that share domains with METTL6: view

Function for METTL6 Gene

Molecular function for METTL6 Gene

UniProtKB/Swiss-Prot Function:
Probable methyltransferase.

Enzyme Numbers (IUBMB) for METTL6 Gene

Gene Ontology (GO) - Molecular Function for METTL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with METTL6: view

Phenotypes for METTL6 Gene

GenomeRNAi human phenotypes for METTL6:
genes like me logo Genes that share phenotypes with METTL6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for METTL6

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL6 Gene

Localization for METTL6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL6 gene
Compartment Confidence
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for METTL6 Gene

Pathways & Interactions for METTL6 Gene

SuperPathways for METTL6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for METTL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL6: view

No data available for Pathways by source and SIGNOR curated interactions for METTL6 Gene

Drugs & Compounds for METTL6 Gene

(8) Drugs for METTL6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Histidine Approved Nutra 0
S-Adenosylmethionine Approved Nutra 0
Tetrahydrofolic acid Approved Nutra 0
3-hydroxyanthranilic acid Experimental Pharma 0
s-adenosylhomocysteine Experimental Pharma 0

(14) Additional Compounds for METTL6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1,6-Dimethoxypyrene
1-Hydroxy-6-methoxypyrene
1-Hydroxyphenanthrene
  • 1-phenanthrenol
  • phenanthren-1-ol
1-Hydroxypyrene
  • 1-Hydroxy pyrene
  • 1-HYDROXYPYRENE
  • 1-Pyrenol
  • Pyren-1-ol
5315-79-7
1-Methoxyphenanthrene
genes like me logo Genes that share compounds with METTL6: view

Transcripts for METTL6 Gene

Unigene Clusters for METTL6 Gene

Methyltransferase like 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL6 Gene

No ASD Table

Relevant External Links for METTL6 Gene

GeneLoc Exon Structure for
METTL6
ECgene alternative splicing isoforms for
METTL6

Expression for METTL6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for METTL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for METTL6 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for METTL6 Gene



Protein tissue co-expression partners for METTL6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of METTL6 Gene:

METTL6

SOURCE GeneReport for Unigene cluster for METTL6 Gene:

Hs.149487

Evidence on tissue expression from TISSUES for METTL6 Gene

  • Nervous system(4.5)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with METTL6: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL6 Gene

Orthologs for METTL6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METTL6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL6 34 35
  • 99.53 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 93 (a)
OneToMany
METTL6 34
  • 91 (n)
-- 35
  • 84 (a)
OneToMany
cow
(Bos Taurus)
Mammalia METTL6 34 35
  • 90.14 (n)
mouse
(Mus musculus)
Mammalia Mettl6 34 16 35
  • 86.59 (n)
rat
(Rattus norvegicus)
Mammalia Mettl6 34
  • 85.44 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia METTL6 35
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia METTL6 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves METTL6 34 35
  • 80.22 (n)
lizard
(Anolis carolinensis)
Reptilia METTL6 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl6 34
  • 72.51 (n)
Str.6152 34
zebrafish
(Danio rerio)
Actinopterygii mettl6 34 35
  • 71.07 (n)
zgc56175 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1367 34
fruit fly
(Drosophila melanogaster)
Insecta CG34195 34 35
  • 58.07 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009818 34
  • 56.11 (n)
worm
(Caenorhabditis elegans)
Secernentea ZK1058.5 34 35
  • 53.6 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ABP140 35
  • 15 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G26200 34
  • 53.22 (n)
rice
(Oryza sativa)
Liliopsida Os03g0143000 34
  • 55.49 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 55 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC3H7.11 34
  • 50 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3599 34
Species where no ortholog for METTL6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL6 Gene

ENSEMBL:
Gene Tree for METTL6 (if available)
TreeFam:
Gene Tree for METTL6 (if available)

Paralogs for METTL6 Gene

Paralogs for METTL6 Gene

(2) SIMAP similar genes for METTL6 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with METTL6: view

Variants for METTL6 Gene

Sequence variations from dbSNP and Humsavar for METTL6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000000393 -- 15,384,792(+) ATCAC(G/T)GTTAT intron-variant
rs1000028728 -- 15,426,696(+) TTCAA(C/T)TCACC intron-variant, upstream-variant-2KB
rs1000062227 -- 15,427,819(+) AGGAA(C/T)ATTGC upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs1000121476 -- 15,427,090(+) GCCTG(A/G)GTGGG intron-variant, upstream-variant-2KB
rs1000143824 -- 15,419,211(+) AAAGC(A/G)ATGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for METTL6 Gene

Variant ID Type Subtype PubMed ID
nsv834621 CNV gain 17160897
nsv834622 CNV gain 17160897

Variation tolerance for METTL6 Gene

Residual Variation Intolerance Score: 29.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.66; 14.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for METTL6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
METTL6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL6 Gene

Disorders for METTL6 Gene

Relevant External Links for METTL6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
METTL6

No disorders were found for METTL6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL6 Gene

Publications for METTL6 Gene

  1. A tRNA methyltransferase paralog is important for ribosome stability and cell division in Trypanosoma brucei. (PMID: 26888608) Fleming I.M. … Alfonzo J.D. (Sci Rep 2016) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order amish. (PMID: 18759275) McArdle P.F. … Shuldiner A.R. (Arthritis Rheum. 2008) 3 64

Products for METTL6 Gene

Sources for METTL6 Gene

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