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Aliases for METTL6 Gene

Aliases for METTL6 Gene

  • Methyltransferase Like 6 2 3
  • EC 63
  • EC 2.1.1.- 4
  • EC 2.1.1 63

External Ids for METTL6 Gene

Previous GeneCards Identifiers for METTL6 Gene

  • GC03M015428
  • GC03M015386

Summaries for METTL6 Gene

GeneCards Summary for METTL6 Gene

METTL6 (Methyltransferase Like 6) is a Protein Coding gene. Among its related pathways are Phenylalanine metabolism and Histidine metabolism. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is METTL8.

UniProtKB/Swiss-Prot for METTL6 Gene

  • Probable methyltransferase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL6 Gene

Genomics for METTL6 Gene

Regulatory Elements for METTL6 Gene

Genomic Location for METTL6 Gene

15,381,275 bp from pter
15,440,566 bp from pter
59,292 bases
Minus strand

Genomic View for METTL6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for METTL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL6 Gene

Proteins for METTL6 Gene

  • Protein details for METTL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Methyltransferase-like protein 6
    Protein Accession:
    Secondary Accessions:
    • Q96LU4

    Protein attributes for METTL6 Gene

    284 amino acids
    Molecular mass:
    33251 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH22400.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for METTL6 Gene


neXtProt entry for METTL6 Gene

Proteomics data for METTL6 Gene at MOPED

Selected DME Specific Peptides for METTL6 Gene

Post-translational modifications for METTL6 Gene

  • Ubiquitination at Lys120
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains for METTL6 Gene

Gene Families for METTL6 Gene

Protein Domains for METTL6 Gene

Suggested Antigen Peptide Sequences for METTL6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the methyltransferase superfamily. METL family.
  • Belongs to the methyltransferase superfamily. METL family.
genes like me logo Genes that share domains with METTL6: view

Function for METTL6 Gene

Molecular function for METTL6 Gene

UniProtKB/Swiss-Prot Function:
Probable methyltransferase.

Enzyme Numbers (IUBMB) for METTL6 Gene

Gene Ontology (GO) - Molecular Function for METTL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with METTL6: view

Phenotypes for METTL6 Gene

GenomeRNAi human phenotypes for METTL6:
genes like me logo Genes that share phenotypes with METTL6: view

Animal Model Products

miRNA for METTL6 Gene

miRTarBase miRNAs that target METTL6

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for METTL6 Gene

Localization for METTL6 Gene

Subcellular locations from

Jensen Localization Image for METTL6 Gene COMPARTMENTS Subcellular localization image for METTL6 gene
Compartment Confidence
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for METTL6 Gene

Pathways for METTL6 Gene

genes like me logo Genes that share pathways with METTL6: view

Pathways by source for METTL6 Gene

2 KEGG pathways for METTL6 Gene

Interacting Proteins for METTL6 Gene

Gene Ontology (GO) - Biological Process for METTL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL6: view

Drugs for METTL6 Gene

(22) HMDB Compounds for METTL6 Gene

Compound Synonyms Cas Number PubMed IDs
  • 1-phenanthrenol
  • 1-Hydroxy pyrene
genes like me logo Genes that share compounds with METTL6: view

Transcripts for METTL6 Gene

Unigene Clusters for METTL6 Gene

Methyltransferase like 6:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for METTL6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL6 Gene

No ASD Table

Relevant External Links for METTL6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL6 Gene

mRNA expression in normal human tissues for METTL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for METTL6 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for METTL6 Gene

SOURCE GeneReport for Unigene cluster for METTL6 Gene Hs.149487

genes like me logo Genes that share expressions with METTL6: view

Expression partners for METTL6 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for METTL6 Gene

Orthologs for METTL6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METTL6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia METTL6 35
  • 90.14 (n)
  • 90.49 (a)
  • 90 (a)
(Canis familiaris)
Mammalia METTL6 35
  • 91 (n)
  • 93.43 (a)
-- 36
  • 93 (a)
-- 36
  • 84 (a)
(Mus musculus)
Mammalia Mettl6 35
  • 86.59 (n)
  • 88.04 (a)
Mettl6 16
Mettl6 36
  • 86 (a)
(Pan troglodytes)
Mammalia METTL6 35
  • 99.53 (n)
  • 99.3 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Mettl6 35
  • 85.44 (n)
  • 86.64 (a)
(Monodelphis domestica)
Mammalia METTL6 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia METTL6 36
  • 81 (a)
(Gallus gallus)
Aves METTL6 35
  • 80.22 (n)
  • 81.72 (a)
  • 74 (a)
(Anolis carolinensis)
Reptilia METTL6 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl6 35
  • 72.51 (n)
  • 77.99 (a)
Str.6152 35
(Danio rerio)
Actinopterygii mettl6 35
  • 71.07 (n)
  • 73.21 (a)
zgc56175 35
mettl6 36
  • 68 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1367 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009818 35
  • 56.11 (n)
  • 55.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34195 35
  • 58.07 (n)
  • 58.59 (a)
CG34195 36
  • 51 (a)
(Caenorhabditis elegans)
Secernentea ZK1058.5 35
  • 53.6 (n)
  • 46 (a)
ZK1058.5 36
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ABP140 36
  • 15 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G26200 35
  • 53.22 (n)
  • 46.91 (a)
(Oryza sativa)
Liliopsida Os03g0143000 35
  • 55.49 (n)
  • 51.5 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3599 35
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC3H7.11 35
  • 50 (n)
  • 43.7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
Species with no ortholog for METTL6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL6 Gene

Gene Tree for METTL6 (if available)
Gene Tree for METTL6 (if available)

Paralogs for METTL6 Gene

Paralogs for METTL6 Gene

(2) SIMAP similar genes for METTL6 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with METTL6: view

Variants for METTL6 Gene

Sequence variations from dbSNP and Humsavar for METTL6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs749845 -- 15,422,811(+) cttaa(C/T)cctgt intron-variant
rs905641 -- 15,401,557(-) CTTTC(C/T)TTTTT intron-variant
rs1051610 -- 15,410,182(-) CTACT(A/G/T)TGTAC utr-variant-3-prime, intron-variant
rs1131813 -- 15,410,395(-) gcagt(A/G)ggtcg utr-variant-3-prime, intron-variant
rs1869851 -- 15,415,442(-) tggtg(G/T)ttcat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for METTL6 Gene

Variant ID Type Subtype PubMed ID
nsv834621 CNV Gain 17160897
nsv834622 CNV Gain 17160897

Relevant External Links for METTL6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL6 Gene

Disorders for METTL6 Gene

No disorders were found for METTL6 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for METTL6 Gene

Publications for METTL6 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order amish. (PMID: 18759275) McArdle P.F. … Shuldiner A.R. (Arthritis Rheum. 2008) 3
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for METTL6 Gene

Sources for METTL6 Gene

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