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Aliases for METTL6 Gene

Aliases for METTL6 Gene

  • Methyltransferase Like 6 2 3 5
  • EC 63
  • EC 2.1.1.- 4
  • EC 2.1.1 63

External Ids for METTL6 Gene

Previous GeneCards Identifiers for METTL6 Gene

  • GC03M015428
  • GC03M015386

Summaries for METTL6 Gene

GeneCards Summary for METTL6 Gene

METTL6 (Methyltransferase Like 6) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is METTL2A.

UniProtKB/Swiss-Prot for METTL6 Gene

  • Probable methyltransferase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL6 Gene

Genomics for METTL6 Gene

Regulatory Elements for METTL6 Gene

Enhancers for METTL6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around METTL6 on UCSC Golden Path with GeneCards custom track

Genomic Location for METTL6 Gene

15,381,063 bp from pter
15,440,566 bp from pter
59,504 bases
Minus strand

Genomic View for METTL6 Gene

Genes around METTL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL6 Gene

Proteins for METTL6 Gene

  • Protein details for METTL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Methyltransferase-like protein 6
    Protein Accession:
    Secondary Accessions:
    • Q96LU4

    Protein attributes for METTL6 Gene

    284 amino acids
    Molecular mass:
    33251 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH22400.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for METTL6 Gene


neXtProt entry for METTL6 Gene

Proteomics data for METTL6 Gene at MOPED

Selected DME Specific Peptides for METTL6 Gene

Post-translational modifications for METTL6 Gene

  • Ubiquitination at Lys 120
  • Modification sites at PhosphoSitePlus

Domains & Families for METTL6 Gene

Gene Families for METTL6 Gene

Protein Domains for METTL6 Gene

Suggested Antigen Peptide Sequences for METTL6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the methyltransferase superfamily. METL family.
  • Belongs to the methyltransferase superfamily. METL family.
genes like me logo Genes that share domains with METTL6: view

Function for METTL6 Gene

Molecular function for METTL6 Gene

UniProtKB/Swiss-Prot Function:
Probable methyltransferase.

Enzyme Numbers (IUBMB) for METTL6 Gene

Phenotypes for METTL6 Gene

GenomeRNAi human phenotypes for METTL6:
genes like me logo Genes that share phenotypes with METTL6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for METTL6

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL6 Gene

Localization for METTL6 Gene

Subcellular locations from

Jensen Localization Image for METTL6 Gene COMPARTMENTS Subcellular localization image for METTL6 gene
Compartment Confidence
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for METTL6 Gene

Pathways & Interactions for METTL6 Gene

SuperPathways for METTL6 Gene

No Data Available

Interacting Proteins for METTL6 Gene

Gene Ontology (GO) - Biological Process for METTL6 Gene


No data available for Pathways by source and SIGNOR curated interactions for METTL6 Gene

Drugs & Compounds for METTL6 Gene

(7) Drugs for METTL6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Histidine Approved Nutra 0
S-Adenosylmethionine Approved Nutra 0
Tetrahydrofolic acid Approved Nutra 0
3-hydroxyanthranilic acid Experimental Pharma 0
5-methyltetrahydrofolate Experimental Pharma 0

(15) Additional Compounds for METTL6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1-phenanthrenol
  • phenanthren-1-ol
  • 1-Hydroxy pyrene
  • 1-Pyrenol
  • Pyren-1-ol
genes like me logo Genes that share compounds with METTL6: view

Transcripts for METTL6 Gene

Unigene Clusters for METTL6 Gene

Methyltransferase like 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for METTL6 Gene

No ASD Table

Relevant External Links for METTL6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL6 Gene

mRNA expression in normal human tissues for METTL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for METTL6 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for METTL6 Gene

SOURCE GeneReport for Unigene cluster for METTL6 Gene Hs.149487

genes like me logo Genes that share expression patterns with METTL6: view

Protein tissue co-expression partners for METTL6 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for METTL6 Gene

Orthologs for METTL6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METTL6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia METTL6 35
  • 90.14 (n)
  • 90.49 (a)
  • 90 (a)
(Canis familiaris)
Mammalia METTL6 35
  • 91 (n)
  • 93.43 (a)
-- 36
  • 93 (a)
-- 36
  • 84 (a)
(Mus musculus)
Mammalia Mettl6 35
  • 86.59 (n)
  • 88.04 (a)
Mettl6 16
Mettl6 36
  • 86 (a)
(Pan troglodytes)
Mammalia METTL6 35
  • 99.53 (n)
  • 99.3 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Mettl6 35
  • 85.44 (n)
  • 86.64 (a)
(Monodelphis domestica)
Mammalia METTL6 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia METTL6 36
  • 81 (a)
(Gallus gallus)
Aves METTL6 35
  • 80.22 (n)
  • 81.72 (a)
  • 74 (a)
(Anolis carolinensis)
Reptilia METTL6 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl6 35
  • 72.51 (n)
  • 77.99 (a)
Str.6152 35
(Danio rerio)
Actinopterygii mettl6 35
  • 71.07 (n)
  • 73.21 (a)
zgc56175 35
mettl6 36
  • 68 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1367 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009818 35
  • 56.11 (n)
  • 55.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34195 35
  • 58.07 (n)
  • 58.59 (a)
CG34195 36
  • 51 (a)
(Caenorhabditis elegans)
Secernentea ZK1058.5 35
  • 53.6 (n)
  • 46 (a)
ZK1058.5 36
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ABP140 36
  • 15 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G26200 35
  • 53.22 (n)
  • 46.91 (a)
(Oryza sativa)
Liliopsida Os03g0143000 35
  • 55.49 (n)
  • 51.5 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3599 35
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC3H7.11 35
  • 50 (n)
  • 43.7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
Species with no ortholog for METTL6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL6 Gene

Gene Tree for METTL6 (if available)
Gene Tree for METTL6 (if available)

Paralogs for METTL6 Gene

Paralogs for METTL6 Gene

(2) SIMAP similar genes for METTL6 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with METTL6: view

Variants for METTL6 Gene

Sequence variations from dbSNP and Humsavar for METTL6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs749845 -- 15,422,811(+) cttaa(C/T)cctgt intron-variant
rs1051610 -- 15,410,182(-) CTACT(A/G/T)TGTAC intron-variant, utr-variant-3-prime
rs1869851 -- 15,415,442(-) tggtg(G/T)ttcat intron-variant
rs1869852 -- 15,415,441(-) ggtgt(C/T)tcatg intron-variant
rs1869853 -- 15,415,329(-) GCTAA(C/T)GTATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for METTL6 Gene

Variant ID Type Subtype PubMed ID
nsv834621 CNV Gain 17160897
nsv834622 CNV Gain 17160897

Variation tolerance for METTL6 Gene

Residual Variation Intolerance Score: 29.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.66; 14.10% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for METTL6 Gene

Disorders for METTL6 Gene

Relevant External Links for METTL6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for METTL6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL6 Gene

Publications for METTL6 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order amish. (PMID: 18759275) McArdle P.F. … Shuldiner A.R. (Arthritis Rheum. 2008) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for METTL6 Gene

Sources for METTL6 Gene