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METTL6 Gene

protein-coding   GIFtS: 50
GCID: GC03M015422

Methyltransferase Like 6

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Methyltransferase Like 61 2
Methyltransferase-Like Protein 62
EC 2.1.1.-3
EC 2.1.18
EC 2.1.1.418

External Ids:    HGNC: 283431   Entrez Gene: 1319652   Ensembl: ENSG000002065627   UniProtKB: Q8TCB73   

Export aliases for METTL6 gene to outside databases

Previous GC identifers: GC03M015428 GC03M015386


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for METTL6 Gene:
METTL6 (methyltransferase like 6) is a protein-coding gene. Diseases associated with METTL6 include malaria. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is METTL2B.

UniProtKB/Swiss-Prot: METL6_HUMAN, Q8TCB7
Function: Probable methyltransferase (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the METTL6 gene promoter:
         TBP   SREBP-1c   SREBP-1b   C/EBPalpha   AREB6   SREBP-1a   POU2F1   POU2F1a   FOXO4   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMETTL6 promoter sequence
   Search Chromatin IP Primers for METTL6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat METTL6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.1   Ensembl cytogenetic band:  3p25.1   HGNC cytogenetic band: 3p25.1

METTL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
METTL6 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M015422:  view genomic region     (about GC identifiers)

Start:
15,422,782 bp from pter      End:
15,482,073 bp from pter
Size:
59,292 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: METL6_HUMAN, Q8TCB7 (See protein sequence)
Recommended Name: Methyltransferase-like protein 6  
Size: 284 amino acids; 33251 Da
Sequence caution: Sequence=AAH22400.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Secondary accessions: Q96LU4
Alternative splicing: 2 isoforms:  Q8TCB7-1   Q8TCB7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for METTL6: NX_Q8TCB7

Explore proteomics data for METTL6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys120
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for METTL6 (Q8TCB7) (see all 5)
     YKVLKPG  FFKDRHW  LIFVLSA  CDFSPRA 


    See METTL6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689609.2  
    ENSEMBL proteins: 
     ENSP00000407613   ENSP00000400885   ENSP00000373300   ENSP00000410726   ENSP00000412006  
     ENSP00000373299   ENSP00000471485  

    METTL6 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for METTL6
    OriGene Protein Over-expression Lysate for METTL6
    OriGene MassSpec for METTL6
    OriGene Custom Protein Services for METTL6
    GenScript Custom Purified and Recombinant Proteins Services for METTL6
    Novus Biologicals METTL6 Protein
    Novus Biologicals METTL6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for METTL6

    METTL6 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals METTL6 Antibodies
    Abcam antibodies for METTL6
    Cloud-Clone Corp. Antibodies for METTL6
    ThermoFisher Antibodies for METTL6
    LSBio Antibodies in human, mouse, rat for METTL6

    METTL6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for METTL6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for METTL6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for METTL6
    Cloud-Clone Corp. CLIAs for METTL6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR026113 MeTrfase
     IPR013217 Methyltransf_12

    Graphical View of Domain Structure for InterPro Entry Q8TCB7

    ProtoNet protein and cluster: Q8TCB7

    UniProtKB/Swiss-Prot: METL6_HUMAN, Q8TCB7
    Similarity: Belongs to the methyltransferase superfamily. METL family


    METTL6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: METL6_HUMAN, Q8TCB7
    Function: Probable methyltransferase (By similarity)

         Enzyme Numbers (IUBMB): EC 2.1.1.-1 EC 2.1.12 EC 2.1.1.412

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008168methyltransferase activity IEA--
         
    METTL6 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for METTL6:
     Increased Salmonella enterica  

         1 MGI phenotypic allele for Mettl6 (no phenotypes)

    METTL6 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for METTL6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for METTL6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for METTL6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for METTL6

    miRNA
    Products:
        
    miRTarBase miRNAs that target METTL6:
    hsa-let-7a-5p (MIRT052628)

    Block miRNA regulation of human, mouse, rat METTL6 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate METTL6:
    hsa-miR-877* hsa-miR-1231 hsa-miR-4288 hsa-miR-632
    SwitchGear 3'UTR luciferase reporter plasmidMETTL6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for METTL6
    Predesigned siRNA for gene silencing in human, mouse, rat METTL6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for METTL6

    Clone
    Products:
         
    OriGene clones in human, mouse for METTL6 (see all 7)
    OriGene ORF clones in mouse, rat for METTL6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: METTL6 (NM_152396)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for METTL6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL6

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for METTL6
    Browse ESI BIO Cell Lines and PureStem Progenitors for METTL6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    extracellular1
    mitochondrion1
    nucleus1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for METTL6 About    
    See pathways by source

    SuperPathContained pathways About
    1Phenylalanine metabolism
    Tyrosine metabolism0.36
    2Histidine metabolism
    Histidine metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Kegg Pathways  (Kegg details for METTL6):
        Histidine metabolism
    Tyrosine metabolism


    METTL6 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for METTL6
    Interactions:

        Search GeneGlobe Interaction Network for METTL6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for METTL6 (ENSP000003733004) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CARNS1ENSP000003082684STRING: ENSP00000308268
    CNDP1ENSP000003516824STRING: ENSP00000351682
    DDCENSP000003506164STRING: ENSP00000350616
    HALENSP000002612084STRING: ENSP00000261208
    HDCENSP000002678454STRING: ENSP00000267845
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process ----

    METTL6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for METTL6 (METL6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for METTL6 gene: 
    NM_152396.2  

    Unigene Cluster for METTL6:

    Methyltransferase like 6
    Hs.149487  [show with all ESTs]
    Unigene Representative Sequence: BC036687
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000443029 ENST00000584799 ENST00000458728 ENST00000383790(uc003bzs.1)
    ENST00000450816(uc011avp.1) ENST00000489881 ENST00000485131 ENST00000453819
    ENST00000383789(uc003bzt.1) ENST00000598878
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat METTL6 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate METTL6:
    hsa-miR-877* hsa-miR-1231 hsa-miR-4288 hsa-miR-632
    SwitchGear 3'UTR luciferase reporter plasmidMETTL6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for METTL6
    Predesigned siRNA for gene silencing in human, mouse, rat METTL6
    Clone
    Products:
         
    OriGene clones in human, mouse for METTL6 (see all 7)
    OriGene ORF clones in mouse, rat for METTL6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: METTL6 (NM_152396)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for METTL6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL6
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for METTL6
    OriGene qSTAR qPCR primer pairs in human, mouse for METTL6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat METTL6
      QuantiTect SYBR Green Assays in human, mouse, rat METTL6
      QuantiFast Probe-based Assays in human, mouse, rat METTL6

    Additional mRNA sequence: 

    AK027185.1 AK057791.1 AK293370.1 BC022400.1 BC036687.1 

    7 DOTS entries:

    DT.97843612  DT.40230392  DT.97815259  DT.117685  DT.100793977  DT.97792161  DT.91749184 

    Selected AceView cDNA sequences (see all 96):

    AA411950 AA890099 BM983888 CA430635 BQ023020 AA411949 Z44406 BU690093 
    CR612029 BU183521 AI805298 AI806529 BG109646 BU941156 AK057791 AA398979 
    BE710761 BU177389 BG700872 BE733338 AI918879 BF345171 NM_152396 CB117757 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    METTL6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    METTL6 Expression
    About this image


    METTL6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Testis (Reproductive System)
    METTL6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    METTL6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.149487
        Custom PCR Arrays for METTL6
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for METTL6
    OriGene qSTAR qPCR primer pairs in human, mouse for METTL6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat METTL6
    QuantiTect SYBR Green Assays in human, mouse, rat METTL6
    QuantiFast Probe-based Assays in human, mouse, rat METTL6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for METTL6 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mettl61 , 5 methyltransferase like 61, 5 86.59(n)1
    88.04(a)1
      14 (19.12 cM)5
    670111  NM_025907.31  NP_080183.11 
     314787985 
    chicken
    (Gallus gallus)
    Aves METTL61 methyltransferase like 6 80.22(n)
    81.72(a)
      420681  XM_004939436.1  XP_004939493.1 
    lizard
    (Anolis carolinensis)
    Reptilia METTL66
    methyltransferase like 6
    74(a)
    1 ↔ 1
    6(36445540-36454930)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.61522 Transcribed sequence with weak similarity to protein more 76.31(n)    BX727765.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc561752 hypothetical protein MGC56175 77.87(n)   393172  BC045969.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG341951 CG34195 58.07(n)
    58.59(a)
      37018  NM_001103890.2  NP_001097360.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ZK1058.51 ZK1058.5 53.6(n)
    46(a)
      175507  NM_065389.4  NP_497790.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ABP1406
    AdoMet-dependent tRNA methyltransferase and actin ...
    15(a)
    1 → many
    XV(784857-786744) YOR239W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G262001 AT2G26200 53.22(n)
    46.91(a)
      817160  NM_179744.2  NP_850075.2 
    rice
    (Oryza sativa)
    Liliopsida Os03g01430001 Os03g0143000 55.49(n)
    51.5(a)
      4331587  NM_001055471.1  NP_001048936.1 


    ENSEMBL Gene Tree for METTL6 (if available)
    TreeFam Gene Tree for METTL6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for METTL6 gene
    METTL2B2  METTL2A2  METTL82  
    2 SIMAP similar genes for METTL6 using alignment to 5 protein entries:     METL6_HUMAN (see all proteins):
    METTL2B    METTL8

    METTL6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for METTL6 (see all 375)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1155627321,2
    F--15450877(+) AACTCG/ATGAGC 1 -- ds50011Minor allele frequency- A:0.02NA 120
    rs1464505191,2
    --15450939(+) AATGAC/TTGGGA 1 -- ds50010--------
    rs731422931,2
    C,F--15450992(+) AACACT/CAGCTA 1 -- ds50012Minor allele frequency- C:0.04WA 120
    rs1903269651,2
    --15450999(+) GCTACA/GTGATT 1 -- ds50010--------
    rs130811191,2
    C,F,H--15451021(+) ATTTAC/ACCCTT 1 -- ds500124Minor allele frequency- A:0.37NS EA NA WA 2766
    rs113833541,2
    C--15451097(+) ATTCT-/TAACTC 1 -- ds50010--------
    rs1811509191,2
    --15451178(+) ATGGCC/GATTCC 1 -- ds50010--------
    rs1490683741,2
    --15451194(+) TCCCCA/CCCAGG 1 -- ds50010--------
    rs1867056111,2
    --15451195(+) CCCCCA/CCAGGG 1 -- ds50010--------
    rs1160742141,2
    C,F--15451339(+) TGAACT/CAAAGG 1 -- ds50012Minor allele frequency- C:0.02WA NA 238

    HapMap Linkage Disequilibrium report for METTL6 (15422782 - 15482073 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for METTL6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834622CNV Gain17160897
    nsv834621CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing METTL6
    DNA2.0 Custom Variant and Variant Library Synthesis for METTL6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for METTL6:    
    About MalaCards
    malaria


    METTL6 for disorders           About GeneDecksing


    Export disorders for METTL6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for METTL6 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with METTL6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (amp 2011)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 131965 HGNC: 28343 AceView: MGC24132 Ensembl:ENSG00000206562 euGenes: HUgn131965
    ECgene: METTL6 Kegg: 131965 H-InvDB: METTL6

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for METTL6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for METTL6 gene:
    Search GeneIP for patents involving METTL6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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