METTL5 Gene
protein-coding GIFtS: 44
GCID: GC02M170666
|
|
methyltransferase like 5
| |
Aliases
for METTL5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Methyltransferase Like 51 2 | | HSPC1331 2 | | Methyltransferase-Like Protein 52 | | EC 2.1.1.-3 |
Export aliases for METTL5 gene to outside databasesPrevious GC identifers: GC02M170493 GC02M170376 GC02M162556 |
Summaries
for METTL5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: METL5_HUMAN, Q9NRN9Function: Probable methyltransferase (By similarity)
|
Genomic Views
for METTL5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the METTL5 gene promoter:
Nkx3-1 AML1a NRSF form 1 Nkx3-1 v1 MIF-1 NRSF form 2 c-Ets-1 GATA-2 FOXL1 Nkx3-1 v2
Other transcription factors
Search SABiosciences Chromatin IP Primers for METTL5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q31.1 Ensembl cytogenetic band: 2q31.1 HGNC cytogenetic band: 2q31.1METTL5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M170666: view genomic region
(about GC identifiers)
Start:
|
170,666,591 bp from pter |
End:
|
170,681,441 bp from pter |
Size:
|
14,851 bases |
Orientation:
|
minus strand |
|
Proteins
for METTL5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: METL5_HUMAN, Q9NRN9 (See
protein sequence)Recommended Name: Methyltransferase-like protein 5 Size: 209 amino acids; 23719 Da
Secondary accessions: D3DPC9 Q9NVX1Explore the universe of human proteins at neXtProt for METTL5: NX_Q9NRN9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NRN9
METTL5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_054887.2
ENSEMBL proteins: ENSP00000386703 ENSP00000395792 ENSP00000387106 ENSP00000260953 ENSP00000386582 ENSP00000376415 ENSP00000307903 ENSP00000440589 ENSP00000387056 ENSP00000444989
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
-- | -- |
METTL5 for ontologies About GeneDecksing
METTL5 Antibody Products:
Assay Products for METTL5: |
Protein
Domains /
Families
for METTL5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
METTL5 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NRN9ProtoNet protein and cluster: Q9NRN9 1 Blocks protein family: IPB002052 N-6 Adenine-specific DNA methylase
UniProtKB/Swiss-Prot: METL5_HUMAN, Q9NRN9Similarity: Belongs to the methyltransferase superfamily. PrmA family |
Function
for METTL5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: METL5_HUMAN, Q9NRN9Function: Probable methyltransferase (By similarity)Enzyme Number (IUBMB): EC 2.1.1.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL5 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: METTL5 (NM_014168) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for METTL5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL5 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
IEA | -- | | GO:0008168 | methyltransferase activity |
IEA | -- | | GO:0008276 | protein methyltransferase activity |
-- | -- |
METTL5 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for METTL5:
Animal Models:
1 MGI phenotypic allele  for Mettl5 (no phenotypes)
METTL5 for phenotypes About GeneDecksing
|
Pathways & Interactions
for METTL5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for METTL5
|
Drugs & Compounds
for METTL5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for METTL5
Search CenterWatch for drugs/clinical trials and news about METTL5 / METL5
|
Transcripts
for METTL5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for METTL5 gene: NM_014168.2 Unigene Cluster for METTL5: Methyltransferase like 5 Hs.743397 [show with all ESTs]Unigene Representative Sequence: BM46575112 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000409837 ENST00000442181 ENST00000409340 ENST00000260953(uc002ufn.3)
ENST00000409965(uc002ufo.3) ENST00000392640(uc002ufp.3) ENST00000484351
ENST00000308099 ENST00000537825 ENST00000410097 ENST00000538491 ENST00000471560
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL5 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: METTL5 (NM_014168) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for METTL5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL5 |
Additional cDNA sequence: AF201938.1 AK001321.1 BC000921.2 BC093014.1 14 DOTS entries: DT.453203 DT.92380116 DT.92458152 DT.100818754 DT.450195 DT.100818751 DT.40249260 DT.121009174 DT.100827681 DT.92324971 DT.92458168 DT.99966013 DT.99995085 DT.121009179 24/150 AceView cDNA sequences (see all 150): BM465735 BU680392 CR616340 AA708611 BM968160 BC000921 BX427680 AA804396 AI363370 AA471208 BI850558 BG152787 BQ681627 BU737397 BU620985 AA902548 CR609377 BQ212086 BG031905 BI438516 AI192155 BG031831 AA256891 BQ777786
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for METTL5 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c |
|---|
|
| SP1: | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for METTL5
|
Expression
for METTL5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| METTL5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCAAAAGAA
About this image
See METTL5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for METTL5
SOURCE GeneReport for Unigene cluster: Hs.743397
SABiosciences Custom PCR Arrays for METTL5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for METTL5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat METTL5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL5 |
Orthologs
for METTL5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for METTL5 gene from 8/25 species (see all 25) About this table
ENSEMBL Gene Tree for METTL5 (if available)
TreeFam Gene Tree for METTL5 (if available) |
Paralogs
for METTL5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for METTL5 gene
METTL5 for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for METTL5
PGOHUM00000242467 PGOHUM00000248232 PGOHUM00000238172 PGOHUM00000245913
|
Genomic Variants
for METTL5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for METTL5 (170666591 - 170681441 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for METTL5
3 CNVs: 90126 32382 90125 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing METTL5 |
|
Disorders
/ Diseases
for METTL5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for METTL5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for METTL5 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with METTL5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 3 Zhang Q.-H.... Chen Z. (2000)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for METTL5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing METTL5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing METTL5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing METTL5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for METTL5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for METTL5 gene:
Search GeneIP for patents involving METTL5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for METTL5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for METTL5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for METTL5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for METTL5 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for METTL5 | | OriGene 3'-UTR Clone for METTL5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for METTL5 | | OriGene Custom Protein Services for METTL5 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat METTL5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing METTL5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat METTL5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL5 |
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 |  |  |  | |
| | | | Search Tocris compounds for METTL5 |
| |  |  |  |  | | | | |
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 |
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 | | | METTL5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL5 |
|  |  |  | | | | ThermoFisher Antibodies for METTL5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL5 |
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