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METTL5 Gene

protein-coding   GIFtS: 46
GCID: GC02M170666

Methyltransferase Like 5

  Search for METTL5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Methyltransferase Like 51 2
HSPC1332
Methyltransferase-Like Protein 52
EC 2.1.1.-3

External Ids:    HGNC: 250061   Entrez Gene: 290812   Ensembl: ENSG000001383827   UniProtKB: Q9NRN93   

Export aliases for METTL5 gene to outside databases

Previous GC identifers: GC02M170493 GC02M170376 GC02M162556


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for METTL5 Gene:
METTL5 (methyltransferase like 5) is a protein-coding gene. GO annotations related to this gene include methyltransferase activity and nucleic acid binding.

UniProtKB/Swiss-Prot: METL5_HUMAN, Q9NRN9
Function: Probable methyltransferase (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the METTL5 gene promoter:
         Nkx3-1   AML1a   NRSF form 1   Nkx3-1 v1   MIF-1   NRSF form 2   c-Ets-1   GATA-2   FOXL1   Nkx3-1 v2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMETTL5 promoter sequence
   Search Chromatin IP Primers for METTL5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat METTL5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

METTL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
METTL5 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M170666:  view genomic region     (about GC identifiers)

Start:
170,666,591 bp from pter      End:
170,681,441 bp from pter
Size:
14,851 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: METL5_HUMAN, Q9NRN9 (See protein sequence)
Recommended Name: Methyltransferase-like protein 5  
Size: 209 amino acids; 23719 Da
Secondary accessions: D3DPC9 Q9NVX1

Explore the universe of human proteins at neXtProt for METTL5: NX_Q9NRN9

Explore proteomics data for METTL5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See METTL5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_054887.2  
    ENSEMBL proteins: 
     ENSP00000386703   ENSP00000395792   ENSP00000387106   ENSP00000260953   ENSP00000386582  
     ENSP00000376415   ENSP00000307903   ENSP00000440589   ENSP00000387056   ENSP00000444989  

    METTL5 Human Recombinant Protein Products:

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    Browse OriGene Protein Over-expression Lysates
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    OriGene Custom Protein Services for METTL5
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    Novus Biologicals METTL5 Protein
    Novus Biologicals METTL5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for METTL5

     
    Search eBioscience for Proteins for METTL5 

    METTL5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for METTL5
    Cloud-Clone Corp. Antibodies for METTL5
    ThermoFisher Antibodies for METTL5
    LSBio Antibodies in human, mouse, rat for METTL5

    METTL5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for METTL5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for METTL5
    Cloud-Clone Corp. CLIAs for METTL5
    Search eBioscience for ELISAs for METTL5 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR007848 Small_mtfrase_dom
     IPR002052 DNA_methylase_N6_adenine_CS

    Graphical View of Domain Structure for InterPro Entry Q9NRN9

    ProtoNet protein and cluster: Q9NRN9

    1 Blocks protein domain: IPB002052 N-6 Adenine-specific DNA methylase

    UniProtKB/Swiss-Prot: METL5_HUMAN, Q9NRN9
    Similarity: Belongs to the methyltransferase superfamily. PrmA family


    Find genes that share domains with METTL5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: METL5_HUMAN, Q9NRN9
    Function: Probable methyltransferase (By similarity)

         Enzyme Number (IUBMB): EC 2.1.1.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0008168methyltransferase activity IEA--
    GO:0008276protein methyltransferase activity ----
         
    Find genes that share ontologies with METTL5           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for METTL5:
     Decreased cell number 

         1 MGI phenotypic allele for Mettl5 (no phenotypes)

    Find genes that share phenotypes with METTL5           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for METTL5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for METTL5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for METTL5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for METTL5

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat METTL5 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate METTL5:
    hsa-miR-579 hsa-miR-664
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for METTL5
    Predesigned siRNA for gene silencing in human, mouse, rat METTL5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for METTL5

    Clone
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    OriGene clones in human, mouse for METTL5 (see all 7)
    OriGene ORF clones in mouse, rat for METTL5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: METTL5 (NM_014168)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for METTL5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL5

    Cell Line
    Products:
         
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    Browse ESI BIO Cell Lines and PureStem Progenitors for METTL5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    mitochondrion2
    nucleus2
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----

    Find genes that share ontologies with METTL5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for METTL5
    Interactions:

        Search GeneGlobe Interaction Network for METTL5

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for METTL5 (ENSP000002609534) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NME1ENSP000000130344STRING: ENSP00000013034
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001510RNA methylation ----
    GO:0006479protein methylation ----
    GO:0008152metabolic process ----
    GO:00094527-methylguanosine RNA capping ----
    GO:0031167rRNA methylation ----

    Find genes that share ontologies with METTL5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for METTL5 (METL5)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for METTL5 gene: 
    NM_014168.2  

    Unigene Cluster for METTL5:

    Methyltransferase like 5
    Hs.470553  [show with all ESTs]
    Unigene Representative Sequence: BM465751
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409837 ENST00000442181 ENST00000409340 ENST00000260953(uc002ufn.3)
    ENST00000409965(uc002ufo.3) ENST00000392640(uc002ufp.3) ENST00000484351
    ENST00000308099 ENST00000537825 ENST00000410097 ENST00000538491 ENST00000471560

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat METTL5 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate METTL5:
    hsa-miR-579 hsa-miR-664
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for METTL5
    Predesigned siRNA for gene silencing in human, mouse, rat METTL5
    Clone
    Products:
         
    OriGene clones in human, mouse for METTL5 (see all 7)
    OriGene ORF clones in mouse, rat for METTL5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: METTL5 (NM_014168)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for METTL5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL5
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for METTL5
    OriGene qSTAR qPCR primer pairs in human, mouse for METTL5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat METTL5
      QuantiTect SYBR Green Assays in human, mouse, rat METTL5
      QuantiFast Probe-based Assays in human, mouse, rat METTL5

    Additional mRNA sequence: 

    AF201938.1 AK001321.1 BC000921.2 BC093014.1 

    16 DOTS entries:

    DT.453203  DT.92380116  DT.92458152  DT.100818754  DT.450195  DT.100818751  DT.92324971  DT.40249260 
    DT.100827681  DT.121009174  DT.121009195  DT.121009128  DT.121009179  DT.92458168  DT.99966013  DT.99995085 

    Selected AceView cDNA sequences (see all 150):

    BQ681627 CR616340 BM755167 BC000921 BM465735 AA902548 BI850558 AI192155 
    BI438516 AA471208 BM854152 CD677352 BU680392 AA708611 BQ777786 AA257137 
    AA256891 AI363370 AA654177 BQ212086 BQ778099 BM968160 BG031831 CD679586 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for METTL5 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
    SP1:                          -     -                 -                                   -                     
    SP2:                                -                 -                                   -                     
    SP3:                                -                 -                                                         
    SP4:                                                  -                                                         
    SP5:                                                  -                                   -                     


    ECgene alternative splicing isoforms for METTL5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    METTL5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCAAAAGAA
    METTL5 Expression
    About this image

    METTL5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    METTL5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.470553
        Custom PCR Arrays for METTL5
    Primer
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    OriGene qPCR primer pairs and template standards for METTL5
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    QuantiFast Probe-based Assays in human, mouse, rat METTL5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for METTL5 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mettl51 , 5 methyltransferase like 51, 5 91.55(n)1
    91.39(a)1
      2 (40.95 cM)5
    754221  NM_029280.31  NP_083556.21 
     698711985 
    chicken
    (Gallus gallus)
    Aves METTL51 methyltransferase like 5 78.53(n)
    82.21(a)
      771367  XM_001233694.3  XP_001233695.1 
    lizard
    (Anolis carolinensis)
    Reptilia METTL56
    methyltransferase like 5
    78(a)
    1 ↔ 1
    GL343362.1(571013-581798)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mettl51 methyltransferase like 5 74.43(n)
    78.64(a)
      595055  NM_001030492.1  NP_001025663.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BQ479876.12   -- 74.34(n)    BQ479876.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG96661 CG9666 57.97(n)
    59.42(a)
      40096  NM_140841.3  NP_649098.2 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_C38D4.91 CELE_C38D4.9 56.19(n)
    45.88(a)
      175637  NM_065589.4  NP_497990.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G288301 AT4G28830 57.38(n)
    55.72(a)
      829004  NM_119027.3  NP_194612.2 
    rice
    (Oryza sativa)
    Liliopsida Os06g01626001 Os06g0162600 56.55(n)
    52.74(a)
      4340217  NM_001063425.1  NP_001056890.1 


    ENSEMBL Gene Tree for METTL5 (if available)
    TreeFam Gene Tree for METTL5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for METTL5 gene

    Find genes that share paralogs with METTL5           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for METTL5
    PGOHUM00000242467 PGOHUM00000248232 PGOHUM00000238172 PGOHUM00000245913


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for METTL5 (see all 340)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1912990781,2
    --170669162(+) GTAGTA/GACTTC 1 -- int10--------
    rs67496571,2
    C,F,H--170669274(+) TGGACG/AAAAAA 1 -- int118Minor allele frequency- A:0.09NS EA WA NA CSA 2223
    rs730164651,2
    C,F--170669388(+) GAGTTT/AAATAA 1 -- int12Minor allele frequency- A:0.04WA 120
    rs728781871,2
    C,F--170669593(+) TGTTGA/TAATGC 1 -- int12Minor allele frequency- T:0.16NA 122
    rs1833569181,2
    --170669605(+) GATTCC/TAGTTC 1 -- int10--------
    rs1862268751,2
    --170669621(+) GTCTGA/GGTGGA 1 -- int10--------
    rs1897604911,2
    --170669622(+) TCTGGA/GTGGAG 1 -- int10--------
    rs1474541531,2
    C--170669637(+) AAATT-/CTTTTT 1 -- int10--------
    rs349156891,2
    C,F--170669638(+) AATTCT/-TTTTT 1 -- int12Minor allele frequency- -:0.50NA 4
    rs1820605131,2
    --170669701(+) GGCGCG/TATCTG 1 -- int10--------

    HapMap Linkage Disequilibrium report for METTL5 (170666591 - 170681441 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for METTL5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3026CNV Loss18451855
    nsv10201CNV Loss18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing METTL5
    DNA2.0 Custom Variant and Variant Library Synthesis for METTL5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for METTL5 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with METTL5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 3 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29081 HGNC: 25006 AceView: HSPC133 Ensembl:ENSG00000138382 euGenes: HUgn29081
    ECgene: METTL5 H-InvDB: METTL5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for METTL5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for METTL5 gene:
    Search GeneIP for patents involving METTL5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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