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Aliases for METTL5 Gene

Aliases for METTL5 Gene

  • Methyltransferase Like 5 2 3 5
  • EC 2.1.1.- 4
  • HSPC133 3

External Ids for METTL5 Gene

Previous GeneCards Identifiers for METTL5 Gene

  • GC02M170493
  • GC02M170376
  • GC02M170666
  • GC02M162556

Summaries for METTL5 Gene

GeneCards Summary for METTL5 Gene

METTL5 (Methyltransferase Like 5) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and protein methyltransferase activity.

UniProtKB/Swiss-Prot for METTL5 Gene

  • Probable methyltransferase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL5 Gene

Genomics for METTL5 Gene

Regulatory Elements for METTL5 Gene

Enhancers for METTL5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around METTL5 on UCSC Golden Path with GeneCards custom track

Promoters for METTL5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around METTL5 on UCSC Golden Path with GeneCards custom track

Genomic Location for METTL5 Gene

169,810,081 bp from pter
169,824,931 bp from pter
14,851 bases
Minus strand

Genomic View for METTL5 Gene

Genes around METTL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL5 Gene

Proteins for METTL5 Gene

  • Protein details for METTL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Methyltransferase-like protein 5
    Protein Accession:
    Secondary Accessions:
    • D3DPC9
    • Q9NVX1

    Protein attributes for METTL5 Gene

    209 amino acids
    Molecular mass:
    23719 Da
    Quaternary structure:
    No Data Available

neXtProt entry for METTL5 Gene

Proteomics data for METTL5 Gene at MOPED

Post-translational modifications for METTL5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for METTL5 Gene

Domains & Families for METTL5 Gene

Gene Families for METTL5 Gene

Suggested Antigen Peptide Sequences for METTL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the methyltransferase superfamily. PrmA family.
  • Belongs to the methyltransferase superfamily. PrmA family.
genes like me logo Genes that share domains with METTL5: view

Function for METTL5 Gene

Molecular function for METTL5 Gene

UniProtKB/Swiss-Prot Function:
Probable methyltransferase.

Enzyme Numbers (IUBMB) for METTL5 Gene

Gene Ontology (GO) - Molecular Function for METTL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with METTL5: view

Phenotypes for METTL5 Gene

GenomeRNAi human phenotypes for METTL5:
genes like me logo Genes that share phenotypes with METTL5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for METTL5

miRNA for METTL5 Gene

miRTarBase miRNAs that target METTL5

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL5 Gene

Localization for METTL5 Gene

Subcellular locations from

Jensen Localization Image for METTL5 Gene COMPARTMENTS Subcellular localization image for METTL5 gene
Compartment Confidence
cytosol 4
nucleus 3
mitochondrion 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for METTL5 Gene

Pathways & Interactions for METTL5 Gene

SuperPathways for METTL5 Gene

No Data Available

Interacting Proteins for METTL5 Gene

Gene Ontology (GO) - Biological Process for METTL5 Gene


No data available for Pathways by source and SIGNOR curated interactions for METTL5 Gene

Drugs & Compounds for METTL5 Gene

No Compound Related Data Available

Transcripts for METTL5 Gene

Unigene Clusters for METTL5 Gene

Methyltransferase like 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for METTL5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP5: - -
SP6: - - - - - -
SP7: - - -
SP8: -

Relevant External Links for METTL5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL5 Gene

mRNA expression in normal human tissues for METTL5 Gene

Protein differential expression in normal tissues from HIPED for METTL5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.3), Skin (13.1), Blymphocyte (6.3), and Lymph node (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for METTL5 Gene

SOURCE GeneReport for Unigene cluster for METTL5 Gene Hs.470553

genes like me logo Genes that share expression patterns with METTL5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for METTL5 Gene

Orthologs for METTL5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METTL5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia METTL5 35
  • 93.46 (n)
  • 95.22 (a)
  • 95 (a)
(Canis familiaris)
Mammalia METTL5 35
  • 93.78 (n)
  • 95.22 (a)
  • 95 (a)
(Mus musculus)
Mammalia Mettl5 35
  • 91.55 (n)
  • 91.39 (a)
Mettl5 16
Mettl5 36
  • 91 (a)
(Pan troglodytes)
Mammalia METTL5 35
  • 99.84 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Mettl5 35
  • 89.79 (n)
  • 89.95 (a)
(Monodelphis domestica)
Mammalia METTL5 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia METTL5 36
  • 89 (a)
(Gallus gallus)
Aves METTL5 35
  • 78.53 (n)
  • 82.21 (a)
  • 81 (a)
(Anolis carolinensis)
Reptilia METTL5 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl5 35
  • 74.43 (n)
  • 78.64 (a)
(Danio rerio)
Actinopterygii mettl5 35
  • 71.71 (n)
  • 77.07 (a)
mettl5 36
  • 76 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000172 35
  • 54.75 (n)
  • 58.45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9666 35
  • 57.97 (n)
  • 59.42 (a)
CG9666 36
  • 58 (a)
(Caenorhabditis elegans)
Secernentea CELE_C38D4.9 35
  • 56.19 (n)
  • 45.88 (a)
C38D4.9 36
  • 43 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G28830 35
  • 57.38 (n)
  • 55.72 (a)
(Glycine max)
eudicotyledons Gma.6728 35
(Oryza sativa)
Liliopsida Os06g0162600 35
  • 56.55 (n)
  • 52.74 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1427 36
  • 57 (a)
Species with no ortholog for METTL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL5 Gene

Gene Tree for METTL5 (if available)
Gene Tree for METTL5 (if available)

Paralogs for METTL5 Gene Pseudogenes for METTL5 Gene

genes like me logo Genes that share paralogs with METTL5: view

No data available for Paralogs for METTL5 Gene

Variants for METTL5 Gene

Sequence variations from dbSNP and Humsavar for METTL5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_051507 -
rs1896289 -- 169,817,903(-) tatac(C/T)ttaag intron-variant
rs3049450 -- 169,820,909(+) GTGTG(-/TG/TGTG)GGTAG intron-variant
rs3217297 -- 169,822,317(-) TCAGA(-/GA)CTGGG intron-variant
rs2081728 -- 169,818,680(-) AGTAC(A/G)TAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for METTL5 Gene

Variant ID Type Subtype PubMed ID
nsv10201 CNV Loss 18304495
nsv3026 CNV Loss 18451855

Variation tolerance for METTL5 Gene

Residual Variation Intolerance Score: 51.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.26; 40.62% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for METTL5 Gene

Disorders for METTL5 Gene

Relevant External Links for METTL5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for METTL5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL5 Gene

Publications for METTL5 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 67
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Use of non-radioactive detection method for north- and southwestern blot. (PMID: 19378081) Franke C. … Bachmann M. (Methods Mol. Biol. 2009) 23

Products for METTL5 Gene

Sources for METTL5 Gene