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Aliases for METTL5 Gene

Aliases for METTL5 Gene

  • Methyltransferase Like 5 2 3
  • Methyltransferase-Like Protein 5 3
  • EC 2.1.1.- 4
  • HSPC133 3

External Ids for METTL5 Gene

Summaries for METTL5 Gene

GeneCards Summary for METTL5 Gene

METTL5 (Methyltransferase Like 5) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and methyltransferase activity.

UniProtKB/Swiss-Prot for METTL5 Gene

  • Probable methyltransferase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL5 Gene

Genomics for METTL5 Gene

Genomic Location for METTL5 Gene

169,810,081 bp from pter
169,824,931 bp from pter
14,851 bases
Minus strand

Genomic View for METTL5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for METTL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL5 Gene

Regulatory Elements for METTL5 Gene

Proteins for METTL5 Gene

  • Protein details for METTL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Methyltransferase-like protein 5
    Protein Accession:
    Secondary Accessions:
    • D3DPC9
    • Q9NVX1

    Protein attributes for METTL5 Gene

    209 amino acids
    Molecular mass:
    23719 Da
    Quaternary structure:
    No Data Available

neXtProt entry for METTL5 Gene

Proteomics data for METTL5 Gene at MOPED

Post-translational modifications for METTL5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for METTL5 Gene

Domains for METTL5 Gene


  • Belongs to the methyltransferase superfamily. PrmA family.:
    • Q9NRN9
genes like me logo Genes that share domains with METTL5: view

No data available for Gene Families for METTL5 Gene

Function for METTL5 Gene

Molecular function for METTL5 Gene

UniProtKB/Swiss-Prot Function: Probable methyltransferase.

Enzyme Numbers (IUBMB) for METTL5 Gene

Gene Ontology (GO) - Molecular Function for METTL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0008168 methyltransferase activity IEA --
GO:0008276 protein methyltransferase activity --
genes like me logo Genes that share ontologies with METTL5: view

Phenotypes for METTL5 Gene

GenomeRNAi human phenotypes for METTL5:
genes like me logo Genes that share phenotypes with METTL5: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for METTL5 Gene

Localization for METTL5 Gene

Subcellular locations from

Jensen Localization Image for METTL5 Gene COMPARTMENTS Subcellular localization image for METTL5 gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for METTL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
genes like me logo Genes that share ontologies with METTL5: view

Pathways for METTL5 Gene

SuperPathways for METTL5 Gene

No Data Available

Interacting Proteins for METTL5 Gene

Gene Ontology (GO) - Biological Process for METTL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001510 RNA methylation --
GO:0006479 protein methylation --
GO:0008152 metabolic process --
GO:0009452 7-methylguanosine RNA capping --
GO:0031167 rRNA methylation --
genes like me logo Genes that share ontologies with METTL5: view

No data available for Pathways by source for METTL5 Gene

Transcripts for METTL5 Gene

Unigene Clusters for METTL5 Gene

Methyltransferase like 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for METTL5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP5: - -
SP6: - - - - - -
SP7: - - -
SP8: -

Relevant External Links for METTL5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL5 Gene

mRNA expression in normal human tissues for METTL5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for METTL5 Gene

SOURCE GeneReport for Unigene cluster for METTL5 Gene Hs.470553

genes like me logo Genes that share expressions with METTL5: view

Orthologs for METTL5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METTL5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia METTL5 36
  • 99.84 (n)
  • 100 (a)
  • 100 (a)
(Bos Taurus)
Mammalia METTL5 36
  • 93.46 (n)
  • 95.22 (a)
  • 95 (a)
(Canis familiaris)
Mammalia METTL5 36
  • 93.78 (n)
  • 95.22 (a)
  • 95 (a)
(Mus musculus)
Mammalia Mettl5 36
  • 91.55 (n)
  • 91.39 (a)
Mettl5 16
Mettl5 37
  • 91 (a)
(Monodelphis domestica)
Mammalia METTL5 37
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia METTL5 37
  • 89 (a)
(Rattus norvegicus)
Mammalia Mettl5 36
  • 89.79 (n)
  • 89.95 (a)
(Gallus gallus)
Aves METTL5 36
  • 78.53 (n)
  • 82.21 (a)
  • 81 (a)
(Anolis carolinensis)
Reptilia METTL5 37
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl5 36
  • 74.43 (n)
  • 78.64 (a)
(Danio rerio)
Actinopterygii mettl5 36
  • 71.71 (n)
  • 77.07 (a)
mettl5 37
  • 76 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000172 36
  • 54.75 (n)
  • 58.45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9666 36
  • 57.97 (n)
  • 59.42 (a)
CG9666 37
  • 58 (a)
(Caenorhabditis elegans)
Secernentea C38D4.9 37
  • 43 (a)
CELE_C38D4.9 36
  • 56.19 (n)
  • 45.88 (a)
(Glycine max)
eudicotyledons Gma.6728 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G28830 36
  • 57.38 (n)
  • 55.72 (a)
(Oryza sativa)
Liliopsida Os06g0162600 36
  • 56.55 (n)
  • 52.74 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1427 37
  • 57 (a)
Species with no ortholog for METTL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL5 Gene

Gene Tree for METTL5 (if available)
Gene Tree for METTL5 (if available)

Paralogs for METTL5 Gene Pseudogenes for METTL5 Gene

genes like me logo Genes that share paralogs with METTL5: view

No data available for Paralogs for METTL5 Gene

Variants for METTL5 Gene

Sequence variations from dbSNP and Humsavar for METTL5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1541776 -- 169,819,717(-) AAAAT(A/G)TTTCT intron-variant
rs1896289 -- 169,817,903(-) tatac(C/T)ttaag intron-variant
rs2081728 -- 169,818,680(-) AGTAC(A/G)TAAGA intron-variant
rs2098982 -- 169,818,410(-) TCAGC(A/G)TCTAG intron-variant
rs2162516 -- 169,820,982(-) GAGGC(C/T)GATAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for METTL5 Gene

Variant ID Type Subtype PubMed ID
nsv10201 CNV Loss 18304495
nsv3026 CNV Loss 18451855

Relevant External Links for METTL5 Gene

HapMap Linkage Disequilibrium report

Disorders for METTL5 Gene

No disorders were found for METTL5 Gene.

No data available for UniProtKB/Swiss-Prot for METTL5 Gene

Publications for METTL5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for METTL5 Gene

Sources for METTL5 Gene

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