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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

METTL4 Gene

protein-coding   GIFtS: 44
GCID: GC18M002527

Methyltransferase Like 4

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Methyltransferase Like 41 2
HsT6612
Methyltransferase-Like Protein 42
EC 2.1.1.-3

External Ids:    HGNC: 247261   Entrez Gene: 648632   Ensembl: ENSG000001015747   UniProtKB: Q8N3J23   

Export aliases for METTL4 gene to outside databases

Previous GC identifer: GC18M002528


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for METTL4 Gene: 
METTL4 (methyltransferase like 4) is a protein-coding gene. Diseases associated with METTL4 include gastric cancer. GO annotations related to this gene include methyltransferase activity and nucleic acid binding.

UniProtKB/Swiss-Prot: METL4_HUMAN, Q8N3J2
Function: Probable methyltransferase (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NT_010859.14  NC_018929.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the METTL4 gene promoter:
         Bach1   STAT5B   GR   ISGF-3   AML1a   Pax-5   IRF-1   CREB   deltaCREB   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMETTL4 promoter sequence
   Search SABiosciences Chromatin IP Primers for METTL4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.32   Ensembl cytogenetic band:  18p11.32   HGNC cytogenetic band: 18p11.31

METTL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
METTL4 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M002527:  view genomic region     (about GC identifiers)

Start:
2,537,524 bp from pter      End:
2,571,508 bp from pter
Size:
33,985 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: METL4_HUMAN, Q8N3J2 (See protein sequence)
Recommended Name: Methyltransferase-like protein 4  
Size: 472 amino acids; 54041 Da
Sequence caution: Sequence=BAB15520.1; Type=Frameshift; Positions=343;
Secondary accessions: B2RNA1 Q2TAA7 Q9H5U9

Explore the universe of human proteins at neXtProt for METTL4: NX_Q8N3J2

Explore proteomics data for METTL4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N3J2

  • METTL4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    METTL4 Protein Expression
    REFSEQ proteins: NP_073751.3  
    ENSEMBL proteins: 
     ENSP00000320349   ENSP00000460774   ENSP00000458290   ENSP00000458415   ENSP00000461097  

    Human Recombinant Protein Products for METTL4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for METTL4
    OriGene Protein Over-expression Lysate for METTL4
    OriGene MassSpec for METTL4 
    OriGene Custom Protein Services for METTL4
    GenScript Custom Purified and Recombinant Proteins Services for METTL4
    Novus Biologicals METTL4 Protein
    Novus Biologicals METTL4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for METTL4 


    METTL4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    OriGene Custom Antibody Services for METTL4
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    Novus Biologicals METTL4 Antibodies
    Abcam antibodies for METTL4
    Cloud-Clone Corp. Antibodies for METTL4 
    ThermoFisher Antibody for METTL4
    LSBio Antibodies in human, mouse, rat for METTL4 

    Assay Products for METTL4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for METTL4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for METTL4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for METTL4 
    Cloud-Clone Corp. CLIAs for METTL4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR007757 MT-A70-like
     IPR002052 DNA_methylase_N6_adenine_CS

    Graphical View of Domain Structure for InterPro Entry Q8N3J2

    ProtoNet protein and cluster: Q8N3J2

    2 Blocks protein domains:
    IPB002052 N-6 Adenine-specific DNA methylase
    IPB007757 MT-A70


    UniProtKB/Swiss-Prot: METL4_HUMAN, Q8N3J2
    Similarity: Belongs to the MT-A70-like family


    METTL4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: METL4_HUMAN, Q8N3J2
    Function: Probable methyltransferase (By similarity)

         Enzyme Number (IUBMB): EC 2.1.1.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0008168methyltransferase activity IEA--
         
    METTL4 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for METTL4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for METTL4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for METTL4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for METTL4 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat METTL4
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate METTL4 (see all 12):
    hsa-miR-3607-3p hsa-miR-607 hsa-miR-378b hsa-miR-422a hsa-miR-513b hsa-miR-186 hsa-miR-15b* hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidMETTL4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for METTL4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat METTL4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for METTL4
    Sirion Biotech Customized adenovirus for overexpression of METTL4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for METTL4 (see all 8)
    OriGene ORF clones in mouse, rat for METTL4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: METTL4 (NM_022840)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for METTL4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL4
    Sirion Biotech Customized lentivirus for stable overexpression of METTL4 
                         Customized lentivirus expression plasmids for stable overexpression of METTL4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for METTL4
    Search LifeMap BioReagents cell lines for METTL4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for METTL4

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006139nucleobase-containing compound metabolic process IEA--

    METTL4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for METTL4 (METL4)

    Search CenterWatch for drugs/clinical trials and news about METTL4 / METL4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for METTL4 gene: 
    NM_022840.3  

    Unigene Cluster for METTL4:

    Methyltransferase like 4
    Hs.126888  [show with all ESTs]
    Unigene Representative Sequence: NM_022840
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000319888(uc010dkj.3 uc002klh.4) ENST00000573134 ENST00000576251
    ENST00000574538 ENST00000577166 ENST00000574676
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat METTL4
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate METTL4 (see all 12):
    hsa-miR-3607-3p hsa-miR-607 hsa-miR-378b hsa-miR-422a hsa-miR-513b hsa-miR-186 hsa-miR-15b* hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidMETTL4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for METTL4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat METTL4
    Clone
    Products:
         
    OriGene clones in human, mouse for METTL4 (see all 8)
    OriGene ORF clones in mouse, rat for METTL4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: METTL4 (NM_022840)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for METTL4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL4
    Sirion Biotech Customized lentivirus for stable overexpression of METTL4 
                         Customized lentivirus expression plasmids for stable overexpression of METTL4 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for METTL4
    OriGene qSTAR qPCR primer pairs in human, mouse for METTL4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat METTL4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL4

    Additional mRNA sequence: 

    AK022584.1 AK026670.1 AK290001.1 AL834296.1 BC056270.1 BC111020.1 BC136766.1 BC136767.1 

    6 DOTS entries:

    DT.455885  DT.75152893  DT.97818852  DT.99985096  DT.95255295  DT.75141757 

    24/57 AceView cDNA sequences (see all 57):

    BQ023905 AA779592 BQ023738 BM723600 BI771801 BU741018 AI336127 AA234433 
    BE856984 AA234346 AA354604 AI370598 AK022584 BX647373 CA423733 AW193476 
    BU624118 BM998566 AI887931 BX103507 AW593636 BQ009802 BX327596 AL834296 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for METTL4    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:                                                                                                
    SP2:                          -     -     -                                                         
    SP3:                                                                          -     -               
    SP4:                          -                                                                     
    SP5:                                                                                                


    ECgene alternative splicing isoforms for METTL4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    METTL4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGCAAGTA
    METTL4 Expression
    About this image


    See METTL4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for METTL4

    SOURCE GeneReport for Unigene cluster: Hs.126888
        SABiosciences Custom PCR Arrays for METTL4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for METTL4
    OriGene qSTAR qPCR primer pairs in human, mouse for METTL4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat METTL4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for METTL4 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mettl41 , 5 methyltransferase like 41, 5 80.78(n)1
    75.53(a)1
      17 (61.17 cM)5
    767811  NM_176917.41  NP_795891.21 
     947270805 
    chicken
    (Gallus gallus)
    Aves METTL41 methyltransferase like 4 67.1(n)
    58.64(a)
      421056  XM_419143.2  XP_419143.3 
    lizard
    (Anolis carolinensis)
    Reptilia METTL46
    methyltransferase like 4
    54(a)
    1 ↔ 1
    4(40247977-40272573)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.194542 Xenopus laevis transcribed sequence with weak similarity more 73.87(n)    BQ385861.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5606861 methyltransferase-like protein 4-like 55.62(n)
    51.18(a)
      560686  XM_684086.4  XP_689178.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG149061 CG14906 47.72(n)
    39.09(a)
      42030  NM_001104346.2  NP_001097816.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C18A3.16
    Protein C18A3.1
    28(a)
    1 ↔ 1
    II(5720163-5721790)


    ENSEMBL Gene Tree for METTL4 (if available)
    TreeFam Gene Tree for METTL4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/742 SNPs in METTL4 are shown (see all 742)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0647314
    ----see VAR_0647312 S F mis40--------
    rs1429012241,2
    --2537030(+) CTAAGC/TATTAT 1 -- ds50010--------
    rs26779031,2
    C,F,A,H--2537065(-) TTTTAC/TAGGCT 1 -- ds500112Minor allele frequency- T:0.44NA WA CSA EA 379
    rs3694423731,2
    C--2537090(+) AAAAAA/CCCCAC 1 -- ds50010--------
    rs1868561981,2
    --2537102(+) AAATTA/CTTACA 1 -- ds50010--------
    rs1902708391,2
    --2537185(+) TAAACC/TAACTG 1 -- ds50010--------
    rs80923651,2
    C,F,A,H--2537186(+) AAACCA/GACTGT 1 -- ds500123Minor allele frequency- G:0.47NS EA NA CSA WA 2766
    rs1506673211,2
    C--2537335(+) ACTTCC/GGAGTA 1 -- ds50010--------
    rs1397455261,2
    --2537351(+) AAAACC/TAGTAC 1 -- ds50010--------
    rs26779021,2
    C,F,H--2537417(-) AACACT/GGGTAC 1 -- ds500118Minor allele frequency- G:0.05NA NS EA WA CSA 817

    HapMap Linkage Disequilibrium report for METTL4 (2537524 - 2571508 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for METTL4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv132209CNV Loss16902084
    nsv909314CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing METTL4
    DNA2.0 Custom Variant and Variant Library Synthesis for METTL4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for METTL4:    About MalaCards
    gastric cancer    


    METTL4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): METTL4

    Export disorders for METTL4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for METTL4 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with METTL4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)2 Varela I....Futreal P.A. (2011)
    5. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    7. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
    8. DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)2 Nusbaum C.... Lander E.S. (2005)
    9. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64863 HGNC: 24726 AceView: METTL4 Ensembl:ENSG00000101574 euGenes: HUgn64863
    ECgene: METTL4 H-InvDB: METTL4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for METTL4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for METTL4 gene:
    Search GeneIP for patents involving METTL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
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     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for METTL4  
     OriGene qPCR primer pairs and template standards for METTL4   OriGene Protein Over-expression Lysate for METTL4  
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     OriGene ORF clones in mouse, rat for METTL4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for METTL4   OriGene Custom Protein Services for METTL4  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat METTL4
     QIAGEN SeqTarget long-range PCR primers for resequencing METTL4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat METTL4
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     GenScript Custom Purified and Recombinant Proteins Services for METTL4 GenScript cDNA clones with any tag delivered in your preferred vector for METTL4
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     Regulatory tfbs in METTL4 promoter
     Search Chromatin IP Primers for METTL4
     RT2 qPCR Primer Assay in human, mouse, rat METTL4
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     SABiosciences Custom PCR Arrays for METTL4
     Search Tocris compounds for METTL4 (METL4)
     Browse Sino Biological Proteins and Antibodies
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
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     Browse ProSpec Recombinant Proteins




     Proteins for METTL4
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     Search LifeMap BioReagents cell lines for METTL4
     Gene Synthesis
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL4
     SwitchGear 3'UTR luciferase reporter plasmids for METTL4
     SwitchGear Promoter luciferase reporter plasmids for METTL4
     ThermoFisher Antibody for METTL4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for METTL4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for METTL4
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     LSBio Antibodies in human, mouse, rat for METTL4
    Customized transgenic rodents for:
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     Biomarker expression
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     Translational medicine
     Tissue-specific gene expresssion
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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