METTL4 Gene
protein-coding GIFtS: 41
GCID: GC18M002527
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methyltransferase like 4
| |
Aliases for METTL4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Methyltransferase Like 41 2 | | HsT6611 2 | | FLJ230171 | | Methyltransferase-Like Protein 42 | | EC 2.1.1.-3 |
Export aliases for METTL4 gene to outside databasesPrevious GC identifer: GC18M002528 |
Summaries for METTL4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: METL4_HUMAN, Q8N3J2Function: Probable methyltransferase (By similarity)
|
Genomic Views for METTL4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010859.14
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the METTL4 gene promoter: Bach1 STAT5B GR ISGF-3 AML1a Pax-5 IRF-1 CREB deltaCREB GR-alpha Other transcription factors
Search SABiosciences Chromatin IP Primers for METTL4
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL4 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18p11.32 Ensembl cytogenetic band: 18p11.32 HGNC cytogenetic band: 18p11.31METTL4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18M002527: view genomic region
(about GC identifiers)
Start:
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2,537,524 bp from pter |
End:
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2,571,508 bp from pter |
Size:
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33,985 bases |
Orientation:
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minus strand |
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Proteins for METTL4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: METL4_HUMAN, Q8N3J2 (See
protein sequence)Recommended Name: Methyltransferase-like protein 4 Size: 472 amino acids; 54041 Da
Sequence caution: Sequence=BAB15520.1; Type=Frameshift; Positions=343;
Secondary accessions: B2RNA1 Q2TAA7 Q9H5U9Explore the universe of human proteins at neXtProt for METTL4: NX_Q8N3J2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N3J2 METTL4 Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins: NP_073751.3 ENSEMBL proteins: ENSP00000320349 ENSP00000460774 ENSP00000458290 ENSP00000458415 ENSP00000461097 Human Recombinant Protein Products for METTL4:
METTL4 Antibody Products: Assay Products for METTL4: |
Protein
Domains / Families for METTL4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
METTL4 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N3J2ProtoNet protein and cluster: Q8N3J2 2 Blocks protein families: IPB002052 N-6 Adenine-specific DNA methylase IPB007757 MT-A70
UniProtKB/Swiss-Prot: METL4_HUMAN, Q8N3J2Similarity: Belongs to the MT-A70-like family |
Function for METTL4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Molecular Function: UniProtKB/Swiss-Prot Summary: METL4_HUMAN, Q8N3J2Function: Probable methyltransferase (By similarity) Enzyme Number (IUBMB): EC 2.1.1.-1
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
IEA | -- | | GO:0008168 | methyltransferase activity |
IEA | -- |
METTL4 for ontologies About GeneDecksing
Animal Models:
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL4 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL4 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: METTL4 (NM_022840) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for METTL4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL4  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL4 |
|
Pathways & Interactions for METTL4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for METTL4
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006139 | nucleobase-containing compound metabolic process |
IEA | -- |
METTL4 for ontologies About GeneDecksing
|
Drugs & Compounds for METTL4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for METTL4 Search CenterWatch for drugs/clinical trials and news about METTL4 / METL4 
|
Transcripts for METTL4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for METTL4 gene: NM_022840.3 Unigene Cluster for METTL4: Methyltransferase like 4 Hs.126888 [show with all ESTs]Unigene Representative Sequence: NM_0228406 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000319888(uc010dkj.3 uc002klh.4) ENST00000573134 ENST00000576251 ENST00000574538 ENST00000577166 ENST00000574676
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL4 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL4 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: METTL4 (NM_022840) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for METTL4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL4  |
Additional cDNA sequence: AK022584.1 AK026670.1 AK290001.1 AL834296.1 BC056270.1 BC111020.1 BC136766.1 BC136767.1 6 DOTS entries: DT.455885 DT.75152893 DT.97818852 DT.99985096 DT.95255295 DT.75141757 24/57 AceView cDNA sequences (see all 57): AA354604 AI336127 AA779592 BU741018 AA234346 BM723600 AA234433 BQ023738 BE856984 BQ023905 BI771801 AK026670 BU624118 BX647373 BE536584 BE501258 NM_022840 W17061 BM828675 BC056270 AI887931 AI038292 BU686877 CA423733 GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for METTL4 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |
| SP4: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for METTL4
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Expression for METTL4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| METTL4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GCAGCAAGTA
 About this image See METTL4 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for METTL4
SOURCE GeneReport for Unigene cluster: Hs.126888 SABiosciences Custom PCR Arrays for METTL4
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for METTL4 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat METTL4 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL4 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL4 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL4 |
Orthologs for METTL4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for METTL4 gene from 9/22 species (see all 22) About this table
ENSEMBL Gene Tree for METTL4 (if available) TreeFam Gene Tree for METTL4 (if available)  |
Paralogs for METTL4 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for METTL4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 18 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for METTL4 (2537524 - 2571508 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for METTL4 1 Indel: 11912  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing METTL4 |
|
Disorders
/ Diseases for METTL4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications for METTL4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for METTL4 gene integrated from 9 sources: (articles sorted by number of sources associating them with METTL4) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)2 Varela I....Futreal P.A. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
- DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)2 Nusbaum C.... Lander E.S. (2005)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
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External Searches for METTL4 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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Genome Databases showing METTL4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing METTL4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing METTL4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for METTL4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for METTL4 gene: Search GeneIP for patents involving METTL4
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for METTL4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
|
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 | |
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for METTL4 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for METTL4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for METTL4 | | OriGene Protein Over-expression Lysate for METTL4 | | Browse OriGene Fluorogenic Cell Assay Kits | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for METTL4 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL4 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | OriGene Purified Protein for METTL4 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for METTL4 | | OriGene Custom Protein Services for METTL4 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat METTL4 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing METTL4 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL4 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat METTL4 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL4 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL4 |
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| | | Search Tocris compounds for METTL4 |
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 | | METTL4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL4 |
|  |  |  |  | | | ThermoFisher Antibody for METTL4 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL4 |
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