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METTL4 Gene

protein-coding   GIFtS: 46
GCID: GC18M002527

Methyltransferase Like 4

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disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Methyltransferase Like 41 2
HsT6612
Methyltransferase-Like Protein 42
EC 2.1.1.-3

External Ids:    HGNC: 247261   Entrez Gene: 648632   Ensembl: ENSG000001015747   UniProtKB: Q8N3J23   

Export aliases for METTL4 gene to outside databases

Previous GC identifer: GC18M002528


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for METTL4 Gene:
METTL4 (methyltransferase like 4) is a protein-coding gene. GO annotations related to this gene include methyltransferase activity and nucleic acid binding.

UniProtKB/Swiss-Prot: METL4_HUMAN, Q8N3J2
Function: Probable methyltransferase (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NT_010859.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the METTL4 gene promoter:
         Bach1   STAT5B   GR   ISGF-3   AML1a   Pax-5   IRF-1   CREB   deltaCREB   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMETTL4 promoter sequence
   Search Chromatin IP Primers for METTL4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat METTL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.32   Ensembl cytogenetic band:  18p11.32   HGNC cytogenetic band: 18p11.31

METTL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
METTL4 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M002527:  view genomic region     (about GC identifiers)

Start:
2,537,524 bp from pter      End:
2,571,508 bp from pter
Size:
33,985 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: METL4_HUMAN, Q8N3J2 (See protein sequence)
Recommended Name: Methyltransferase-like protein 4  
Size: 472 amino acids; 54041 Da
Sequence caution: Sequence=BAB15520.1; Type=Frameshift; Positions=343;
Secondary accessions: B2RNA1 Q2TAA7 Q9H5U9

Explore the universe of human proteins at neXtProt for METTL4: NX_Q8N3J2

Explore proteomics data for METTL4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See METTL4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_073751.3  
    ENSEMBL proteins: 
     ENSP00000320349   ENSP00000460774   ENSP00000458290   ENSP00000458415   ENSP00000477089  
     ENSP00000461097  

    METTL4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for METTL4
    OriGene Protein Over-expression Lysate for METTL4
    OriGene MassSpec for METTL4
    OriGene Custom Protein Services for METTL4
    GenScript Custom Purified and Recombinant Proteins Services for METTL4
    Novus Biologicals METTL4 Protein
    Novus Biologicals METTL4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for METTL4

     
    Search eBioscience for Proteins for METTL4 

     
    antibodies-online proteins for METTL4 (2 products) 

     
    antibodies-online peptides for METTL4

    METTL4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for METTL4
    Cloud-Clone Corp. Antibodies for METTL4
    ThermoFisher Antibody for METTL4
    LSBio Antibodies in human, mouse, rat for METTL4
    antibodies-online antibodies for METTL4 (16 products) 

    METTL4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for METTL4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for METTL4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for METTL4
    Cloud-Clone Corp. CLIAs for METTL4
    Search eBioscience for ELISAs for METTL4 
    antibodies-online kits for METTL4 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR007757 MT-A70-like
     IPR002052 DNA_methylase_N6_adenine_CS

    Graphical View of Domain Structure for InterPro Entry Q8N3J2

    ProtoNet protein and cluster: Q8N3J2

    2 Blocks protein domains:
    IPB002052 N-6 Adenine-specific DNA methylase
    IPB007757 MT-A70


    UniProtKB/Swiss-Prot: METL4_HUMAN, Q8N3J2
    Similarity: Belongs to the MT-A70-like family


    Find genes that share domains with METTL4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: METL4_HUMAN, Q8N3J2
    Function: Probable methyltransferase (By similarity)

         Enzyme Number (IUBMB): EC 2.1.1.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0008168methyltransferase activity IEA--
         
    Find genes that share ontologies with METTL4           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for METTL4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for METTL4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for METTL4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for METTL4

    miRNA
    Products:
        
    miRTarBase miRNAs that target METTL4:
    hsa-mir-197-3p (MIRT048094)

    Block miRNA regulation of human, mouse, rat METTL4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate METTL4 (see all 12):
    hsa-miR-3607-3p hsa-miR-607 hsa-miR-378b hsa-miR-422a hsa-miR-513b hsa-miR-186 hsa-miR-15b* hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidMETTL4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for METTL4
    Predesigned siRNA for gene silencing in human, mouse, rat METTL4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for METTL4

    Clone
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    OriGene clones in human, mouse for METTL4 (see all 7)
    OriGene ORF clones in mouse, rat for METTL4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: METTL4 (NM_022840)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for METTL4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL4

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for METTL4
    Browse ESI BIO Cell Lines and PureStem Progenitors for METTL4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for METTL4
    Interactions:

        Search GeneGlobe Interaction Network for METTL4

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for METTL4 (ENSP000003203494) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COQ7ENSP000003223164STRING: ENSP00000322316
    WTAPENSP000003511414STRING: ENSP00000351141
    FBXO18ENSP000003693354STRING: ENSP00000369335
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006139nucleobase-containing compound metabolic process IEA--

    Find genes that share ontologies with METTL4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for METTL4 (METL4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for METTL4 gene: 
    NM_022840.3  

    Unigene Cluster for METTL4:

    Methyltransferase like 4
    Hs.126888  [show with all ESTs]
    Unigene Representative Sequence: NM_022840
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000319888(uc010dkj.3 uc002klh.4) ENST00000573134 ENST00000576251
    ENST00000574538 ENST00000577166 ENST00000609769 ENST00000574676
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat METTL4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate METTL4 (see all 12):
    hsa-miR-3607-3p hsa-miR-607 hsa-miR-378b hsa-miR-422a hsa-miR-513b hsa-miR-186 hsa-miR-15b* hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidMETTL4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for METTL4
    Predesigned siRNA for gene silencing in human, mouse, rat METTL4
    Clone
    Products:
         
    OriGene clones in human, mouse for METTL4 (see all 7)
    OriGene ORF clones in mouse, rat for METTL4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: METTL4 (NM_022840)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for METTL4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for METTL4
    OriGene qSTAR qPCR primer pairs in human, mouse for METTL4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat METTL4
      QuantiTect SYBR Green Assays in human, mouse, rat METTL4
      QuantiFast Probe-based Assays in human, mouse, rat METTL4

    Additional mRNA sequence: 

    AK022584.1 AK026670.1 AK290001.1 AL834296.1 BC056270.1 BC111020.1 BC136766.1 BC136767.1 

    6 DOTS entries:

    DT.455885  DT.75152893  DT.97818852  DT.99985096  DT.95255295  DT.75141757 

    Selected AceView cDNA sequences (see all 57):

    AA234433 BE856984 BQ023738 BM723600 BU741018 BI771801 AI336127 AA779592 
    AA354604 BQ023905 AA234346 CA423733 AW593636 BU624118 BX103507 BQ009802 
    BU686909 BQ049172 W17061 NM_022840 AK026670 AA243453 BF111896 AI038292 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for METTL4    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:                                                                                                
    SP2:                          -     -     -                                                         
    SP3:                                                                          -     -               
    SP4:                          -                                                                     
    SP5:                                                                                                


    ECgene alternative splicing isoforms for METTL4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    METTL4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGCAAGTA
    METTL4 Expression
    About this image

    METTL4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    METTL4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.126888
        Custom PCR Arrays for METTL4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for METTL4
    OriGene qSTAR qPCR primer pairs in human, mouse for METTL4
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    QuantiTect SYBR Green Assays in human, mouse, rat METTL4
    QuantiFast Probe-based Assays in human, mouse, rat METTL4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for METTL4 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mettl41 , 5 methyltransferase like 41, 5 80.78(n)1
    75.53(a)1
      17 (61.17 cM)5
    767811  NM_176917.41  NP_795891.21 
     947270805 
    chicken
    (Gallus gallus)
    Aves METTL41 methyltransferase like 4 67.62(n)
    58.99(a)
      421056  XM_419143.3  XP_419143.3 
    lizard
    (Anolis carolinensis)
    Reptilia METTL46
    methyltransferase like 4
    52(a)
    1 ↔ 1
    4(40247977-40272573)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.194542 Xenopus laevis transcribed sequence with weak similarity more 73.87(n)    BQ385861.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5606861 methyltransferase-like protein 4-like 55.62(n)
    51.18(a)
      560686  XM_684086.5  XP_689178.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG149061 CG14906 47.81(n)
    38.89(a)
      42030  NM_142316.2  NP_650573.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C18A3.16
    Protein C18A3.1 (C18A3.1) mRNA, complete cds
    28(a)
    1 ↔ 1
    II(5720163-5721790) WBGene00015939


    ENSEMBL Gene Tree for METTL4 (if available)
    TreeFam Gene Tree for METTL4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for METTL4 (see all 742)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1429012241,2
    --2537030(+) CTAAGC/TATTAT 1 -- ds50010--------
    rs26779031,2
    C,F,A,H--2537065(-) TTTTAC/TAGGCT 1 -- ds500112Minor allele frequency- T:0.44NA WA CSA EA 379
    rs3694423731,2
    C--2537090(+) AAAAAA/CCCCAC 1 -- ds50010--------
    rs1868561981,2
    --2537102(+) AAATTA/CTTACA 1 -- ds50010--------
    rs1902708391,2
    --2537185(+) TAAACC/TAACTG 1 -- ds50010--------
    rs80923651,2
    C,F,A,H--2537186(+) AAACCA/GACTGT 1 -- ds500123Minor allele frequency- G:0.47NS EA NA CSA WA 2766
    rs1506673211,2
    C--2537335(+) ACTTCC/GGAGTA 1 -- ds50010--------
    rs1397455261,2
    --2537351(+) AAAACC/TAGTAC 1 -- ds50010--------
    rs26779021,2
    C,F,H--2537417(-) AACACT/GGGTAC 1 -- ds500118Minor allele frequency- G:0.05NA NS EA WA CSA 817
    rs10473631,2
    C,F,A,H--2537589(-) ATGGAG/ACTATT 1 -- ut3116Minor allele frequency- A:0.14NS EA NA CSA WA 2078

    HapMap Linkage Disequilibrium report for METTL4 (2537524 - 2571508 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for METTL4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv132209CNV Loss16902084
    nsv909314CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing METTL4
    DNA2.0 Custom Variant and Variant Library Synthesis for METTL4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with METTL4           About GenesLikeMe

    Genetic Association Database (GAD): METTL4

    Export disorders for METTL4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for METTL4 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with METTL4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Genome-wide association study of sensory disturbances in the inferior alveolar nerve after bilateral sagittal split ramus osteotomy. (PubMed id 23834954)1 Kobayashi D....Fukuda K. (Mol Pain 2013)
    5. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)2 Varela I....Futreal P.A. (Nature 2011)
    6. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    8. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H.... Kim N.S. (Mamm. Genome 2005)
    9. DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)2 Nusbaum C.... Lander E.S. (Nature 2005)
    10. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64863 HGNC: 24726 AceView: METTL4 Ensembl:ENSG00000101574 euGenes: HUgn64863
    ECgene: METTL4 H-InvDB: METTL4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for METTL4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for METTL4 gene:
    Search GeneIP for patents involving METTL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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