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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

METTL3 Gene

protein-coding   GIFtS: 55
GCID: GC14M021966

Methyltransferase Like 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Methyltransferase Like 31 2     M6A2
N6-Adenosine-Methyltransferase 70 KDa Subunit1 2     Spo82
Methyltransferase-Like Protein 32 3     AdoMet-Binding Subunit Of The Human MRNA (N6-Adenosine)-Methyltransferase2
MT-A702 3     MRNA M(6)A Methyltransferase2
EC 2.1.1.623 8     MTA703
IME42 5     

External Ids:    HGNC: 175631   Entrez Gene: 563392   Ensembl: ENSG000001658197   OMIM: 6124725   UniProtKB: Q86U443   

Export aliases for METTL3 gene to outside databases

Previous GC identifers: GC14M015753 GC14M019956 GC14M021036 GC14U900552 GC14M002084


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for METTL3 Gene:
This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is
involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming
N6-methyladenosine. (provided by RefSeq, Jul 2008)

GeneCards Summary for METTL3 Gene: 
METTL3 (methyltransferase like 3) is a protein-coding gene. Diseases associated with METTL3 include aicardi syndrome, and prostatitis, and among its related super-pathways are mRNA Processing and Generic Transcription Pathway. GO annotations related to this gene include mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity and RNA binding.

UniProtKB/Swiss-Prot: MTA70_HUMAN, Q86U44
Function: N6-methyltransferase that methylates adenosine residues of some mRNAs. N6-methyladenosine (m6A), which
is present at internal sites of some mRNAs, may play a role in the efficiency of mRNA splicing, transport or
translation

Gene Wiki entry for METTL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the METTL3 gene promoter:
         GR   RP58   SREBP-1c   MyoD   c-Ets-1   SREBP-1b   CREB   SREBP-1a   deltaCREB   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMETTL3 promoter sequence
   Search SABiosciences Chromatin IP Primers for METTL3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.1   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.1

METTL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
METTL3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M021966:  view genomic region     (about GC identifiers)

Start:
21,966,277 bp from pter      End:
21,979,517 bp from pter
Size:
13,241 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MTA70_HUMAN, Q86U44 (See protein sequence)
Recommended Name: N6-adenosine-methyltransferase 70 kDa subunit  
Size: 580 amino acids; 64474 Da
Subcellular location: Nucleus speckle. Note=Colocalizes with speckles in interphase nuclei. Suggesting that it may
be associated with nuclear pre-mRNA splicing components
Secondary accessions: O14736 Q86V05 Q9HB32
Alternative splicing: 2 isoforms:  Q86U44-1   Q86U44-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for METTL3: NX_Q86U44

Explore proteomics data for METTL3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86U44

  • 2 DME Specific Peptides for METTL3 (Q86U44)
     TCKYVHYE  FLWVTGRAMELGRECL 

    METTL3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    METTL3 Protein Expression
    REFSEQ proteins: NP_062826.2  
    ENSEMBL proteins: 
     ENSP00000440598   ENSP00000298717   ENSP00000442407   ENSP00000445523   ENSP00000437692  
     ENSP00000366766   ENSP00000442316  
    Reactome Protein details: Q86U44
    Human Recombinant Protein Products for METTL3: 
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    Novus Biologicals METTL3 Protein
    Novus Biologicals METTL3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for METTL3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9409616
    GO:0005654nucleoplasm TAS--
    GO:0016607nuclear speck IEA--

    METTL3 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for METTL3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR007757 MT-A70-like
     IPR025848 MT-A70

    Graphical View of Domain Structure for InterPro Entry Q86U44

    ProtoNet protein and cluster: Q86U44

    1 Blocks protein domain: IPB007757 MT-A70

    UniProtKB/Swiss-Prot: MTA70_HUMAN, Q86U44
    Similarity: Belongs to the MT-A70-like family


    METTL3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTA70_HUMAN, Q86U44
    Function: N6-methyltransferase that methylates adenosine residues of some mRNAs. N6-methyladenosine (m6A), which
    is present at internal sites of some mRNAs, may play a role in the efficiency of mRNA splicing, transport or
    translation
    Catalytic activity: S-adenosyl-L-methionine + m(7)G(5')pppAm = S-adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am

         Enzyme Number (IUBMB): EC 2.1.1.621 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0008168methyltransferase activity ----
    GO:0016422mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity IMP9409616
         
    METTL3 for ontologies           About GeneDecksing


    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for METTL3 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for METTL3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA0.85
    mRNA processing0.46
    mRNA Processing0.85
    2Generic Transcription Pathway
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for METTL3
        mRNA processing

    3        Reactome Pathways for METTL3
        Gene Expression
    mRNA Processing
    Processing of Capped Intron-Containing Pre-mRNA



    METTL3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for METTL3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for METTL3 (Q86U443 ENSP000003667664) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    METTL14Q9HCE53I2D: score=5 
    AGAP3Q96P473I2D: score=3 
    --ensp: ENSP000002987174STRING: ensp: ENSP00000298717
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001510RNA methylation IMP9409616
    GO:0006139nucleobase-containing compound metabolic process ----
    GO:0010467gene expression TAS--

    METTL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for METTL3 (MTA70)

    3 HMDB Compounds for METTL3    About this table
    CompoundSynonyms CAS #PubMed Ids
    N6-MethyladenosineN-methyladenosine (see all 9)1867-73-8--
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--

    Search CenterWatch for drugs/clinical trials and news about METTL3 / MTA70

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for METTL3 gene: 
    NM_019852.3  

    Unigene Cluster for METTL3:

    Methyltransferase like 3
    Hs.168799  [show with all ESTs]
    Unigene Representative Sequence: AK097873
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000539760 ENST00000298717(uc001wbc.3) ENST00000544500(uc001wbb.3)
    ENST00000396522 ENST00000537163(uc010tlw.1) ENST00000543235 ENST00000544248
    ENST00000536201(uc010tlx.2) ENST00000542054(uc021rox.1) ENST00000539910
    ENST00000377543 ENST00000367606 ENST00000545319 ENST00000545788 ENST00000538267

    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL3

    Additional mRNA sequence: 

    AK000222.1 AK093509.1 AK097873.1 AK098655.1 AK124183.1 AK300289.1 AK304251.1 AK304570.1 
    BC001650.2 BC003031.1 BC014427.1 BC052244.1 BX247964.1 

    24/30 DOTS entries (see all 30):

    DT.100879717  DT.40282672  DT.91974604  DT.100702386  DT.120763185  DT.100806117  DT.97859872  DT.100879718 
    DT.100879708  DT.100879710  DT.120763138  DT.40109746  DT.40132729  DT.100879707  DT.120763112  DT.120763170 
    DT.95165100  DT.100879701  DT.100879715  DT.95132862  DT.100037293  DT.120763103  DT.120763183  DT.120763142 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for METTL3 (see all 16)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                  -     -     -                 -                           
    SP3:                                                                                                                                -                           
    SP4:                                -     -     -     -     -     -                                   -     -     -                 -     -                     
    SP5:                                -     -     -     -     -     -                                   -     -     -                 -                           

    ExUns: 11b · 11c · 11d ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for METTL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    METTL3 expression in normal human tissues (normalized intensities)      METTL3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTCTGTAAG
    METTL3 Expression
    About this image


    METTL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             b cells   
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Ovary (Reproductive System)
             oocyte   
     
     Breast (Uncategorized)
             breast epithelium   
     
     Epithelium
             breast epithelium   

    See METTL3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for METTL3

    SOURCE GeneReport for Unigene cluster: Hs.168799

    UniProtKB/Swiss-Prot: MTA70_HUMAN, Q86U44
    Tissue specificity: Widely expressed at low level. Expressed in spleen, thymus, prostate, testis, ovary, small
    intestine, colon and peripheral blood leukocytes

        SABiosciences Custom PCR Arrays for METTL3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for METTL3 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mettl31 , 5 methyltransferase like 31, 5 90.06(n)1
    97.07(a)1
      14 (26.88 cM)5
    563351  NM_019721.21  NP_062695.21 
     522946685 
    lizard
    (Anolis carolinensis)
    Reptilia METTL36
    Uncharacterized protein
    86(a)
    1 ↔ 1
    GL343466.1(480366-493852)
    zebrafish
    (Danio rerio)
    Actinopterygii mettl31 methyltransferase like 3 65.79(n)
    71.35(a)
      100004398  NM_212780.1  NP_997945.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mta701 Mta70 homologue 55.06(n)
    52.25(a)
      42844  NM_142947.3  NP_651204.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes IME4(YGL192W)4 Probable mRNA N6-adenosine methyltransferase required more   --   7(142246-144048) 852683  NP_011323.1 


    ENSEMBL Gene Tree for METTL3 (if available)
    TreeFam Gene Tree for METTL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/291 SNPs in METTL3 are shown (see all 291)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1869112681,2
    C--21967884(+) CAAAAA/GAAAGC 1 -- int10--------
    rs11391301,2
    C,F,H--21967916(+) CAGAGA/GTTTAG 2 N syn136Minor allele frequency- G:0.49MN EA NA NS WA CSA EU 10531
    rs2012645951,2
    C--21967946(+) ATGGCC/TCTAGA 2 R syn10--------
    rs1907542321,2
    --21968059(+) TGAACA/GTTTAC 1 -- int10--------
    rs1826733251,2
    --21968072(+) GCACAC/TCACCA 1 -- int10--------
    rs1858607551,2
    --21968175(+) GGGTAA/GAATTT 1 -- int10--------
    rs1430740131,2
    --21968203(+) TAGGAA/CTCAGT 1 -- int10--------
    rs1511813981,2
    C--21968246(+) CGCCTA/GTAATC 1 -- int10--------
    rs1896896251,2
    --21968319(+) TAACAC/TGGTGA 1 -- int10--------
    rs799631341,2
    C--21968390(+) GTAATA/CCCAGC 1 -- int10--------

    HapMap Linkage Disequilibrium report for METTL3 (21966277 - 21979517 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for METTL3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422459CNV Duplication17116639
    nsv85879CNV Loss16902084

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612472    OMIM disorders: --

    2 diseases for METTL3:    About MalaCards
    aicardi syndrome    prostatitis


    METTL3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): METTL3

    Export disorders for METTL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for METTL3 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with METTL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
    4. Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase. (PubMed id 9409616)1, 2 Bokar J.A.... Rottman F.M. (1997)
    5. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56339 HGNC: 17563 Ensembl:ENSG00000165819 euGenes: HUgn56339 ECgene: METTL3
    H-InvDB: METTL3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for METTL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for METTL3 gene:
    Search GeneIP for patents involving METTL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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