METTL3 Gene
protein-coding GIFtS: 52
GCID: GC14M021966
|
|
methyltransferase like 3
| |
Aliases
for METTL3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Methyltransferase Like 31 2 | | IME42 5 | | MT-A701 2 3 | | AdoMet-Binding Subunit Of The Human MRNA (N6-Adenosine)-Methyltransferase2 | | M6A1 2 | | MRNA M(6)A Methyltransferase2 | | Spo81 2 | | N6-Adenosine-Methyltransferase 70 KDa Subunit2 | | Methyltransferase-Like Protein 32 3 | | MTA703 | | EC 2.1.1.623 8 | | |
Export aliases for METTL3 gene to outside databasesPrevious GC identifers: GC14M015753 GC14M019956 GC14M021036 GC14U900552 GC14M002084 |
Summaries
for METTL3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for METTL3:
This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involvedin the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: MTA70_HUMAN, Q86U44Function: N6-methyltransferase that methylates adenosine residues of some mRNAs. N6-methyladenosine (m6A), which ispresent at internal sites of some mRNAs, may play a role in the efficiency of mRNA splicing, transport or translation
Gene Wiki entry for METTL3
|
Genomic Views
for METTL3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the METTL3 gene promoter:
GR RP58 SREBP-1c MyoD c-Ets-1 SREBP-1b CREB SREBP-1a deltaCREB GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for METTL3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q11.1 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11.1METTL3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M021966: view genomic region
(about GC identifiers)
Start:
|
21,966,191 bp from pter |
End:
|
21,979,517 bp from pter |
Size:
|
13,327 bases |
Orientation:
|
minus strand |
|
Proteins
for METTL3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MTA70_HUMAN, Q86U44 (See
protein sequence)Recommended Name: N6-adenosine-methyltransferase 70 kDa subunit Size: 580 amino acids; 64474 Da
Subcellular location: Nucleus speckle. Note=Colocalizes with speckles in interphase nuclei. Suggesting that it may beassociated with nuclear pre-mRNA splicing components
Secondary accessions: O14736 Q86V05 Q9HB32Alternative splicing: 2 isoforms: Q86U44-1 Q86U44-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for METTL3: NX_Q86U44
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86U44
2 DME Specific Peptides for METTL3 (Q86U44)
METTL3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_062826.2
ENSEMBL proteins: ENSP00000441019 ENSP00000440598 ENSP00000298717 ENSP00000442407 ENSP00000445523 ENSP00000437692 ENSP00000366766 ENSP00000398280 ENSP00000442316 Reactome Protein details: Q86U44
Human Recombinant Protein Products for METTL3:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
METTL3 for ontologies About GeneDecksing
METTL3 Antibody Products:
Assay Products for METTL3: |
Protein
Domains /
Families
for METTL3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
METTL3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86U44ProtoNet protein and cluster: Q86U44 1 Blocks protein family: IPB007757 MT-A70
UniProtKB/Swiss-Prot: MTA70_HUMAN, Q86U44Similarity: Belongs to the MT-A70-like family |
Function
for METTL3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: MTA70_HUMAN, Q86U44Function: N6-methyltransferase that methylates adenosine residues of some mRNAs. N6-methyladenosine (m6A), which ispresent at internal sites of some mRNAs, may play a role in the efficiency of mRNA splicing, transport or translationCatalytic activity: S-adenosyl-L-methionine + m(7)G(5')pppAm = S-adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am Enzyme Number (IUBMB): EC 2.1.1.621 2
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003723 | RNA binding |
IEA | -- | | GO:0008168 | methyltransferase activity |
-- | -- | | GO:0016422 | mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity |
IMP | 9409616 |
METTL3 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: METTL3 (NM_019852) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for METTL3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL3 |
|
Pathways & Interactions
for METTL3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | mRNA Splicing - Major Pathway | | | 2 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for METTL3
3 
Reactome Pathways for METTL3
METTL3 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for METTL3
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
3 Interacting proteins for METTL3 (Q86U443 ENSP000003667664) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
METTL3 for ontologies About GeneDecksing
|
Drugs & Compounds
for METTL3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for METTL3
3 HMDB Compounds for METTL3 About this table
Search CenterWatch for drugs/clinical trials and news about METTL3 / MTA70
|
Transcripts
for METTL3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for METTL3 gene: NM_019852.3 Unigene Cluster for METTL3: Methyltransferase like 3 Hs.168799 [show with all ESTs]Unigene Representative Sequence: AK09787317 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000544919 ENST00000539760 ENST00000298717(uc001wbc.3) ENST00000544500(uc001wbb.3)
ENST00000396522 ENST00000537163(uc010tlw.1) ENST00000543235 ENST00000544248
ENST00000536201(uc010tlx.2) ENST00000542054(uc021rox.1) ENST00000539910
ENST00000377543 ENST00000440691 ENST00000367606 ENST00000545319 ENST00000545788
ENST00000538267
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: METTL3 (NM_019852) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for METTL3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL3 |
Additional cDNA sequence: AK000222.1 AK093509.1 AK097873.1 AK098655.1 AK124183.1 AK300289.1 AK304251.1 AK304570.1 BC001650.2 BC003031.1 BC014427.1 BC052244.1 BX247964.1 24/30 DOTS entries (see all 30): DT.100879717 DT.40282672 DT.91974604 DT.100702386 DT.120763185 DT.100806117 DT.97859872 DT.100879718 DT.100879708 DT.100879710 DT.120763138 DT.40109746 DT.40132729 DT.100879707 DT.120763112 DT.120763170 DT.95165100 DT.100879701 DT.100879715 DT.95132862 DT.100037293 DT.120763103 DT.120763183 DT.120763142
GeneLoc Exon Structure
5/16 Alternative Splicing Database (ASD) splice patterns (SP) for METTL3 (see all 16) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | - | | - | | - | | | | | | - | | - | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | - | | - | | - | | | | | | - | | | | | | | | | |
| ExUns: | 11b | · | 11c | · | 11d | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for METTL3
|
Expression
for METTL3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| METTL3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTCTGTAAG
About this image
See METTL3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for METTL3
SOURCE GeneReport for Unigene cluster: Hs.168799
UniProtKB/Swiss-Prot: MTA70_HUMAN, Q86U44Tissue specificity: Widely expressed at low level. Expressed in spleen, thymus, prostate, testis, ovary, smallintestine, colon and peripheral blood leukocytes
SABiosciences Custom PCR Arrays for METTL3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for METTL3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat METTL3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL3 |
Orthologs
for METTL3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for METTL3 gene from 5/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
METTL36 |
-- |
88(a) |
1 ↔ 1 |
GL343466.1(485360-493681) |
zebrafish
(Danio rerio) |
Actinopterygii |
mettl31 |
methyltransferase like 3 |
65.79(n)
71.35(a) |
|
100004398 NM_212780.1 NP_997945.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Mta701 |
Mta70 homologue |
55.06(n)
52.25(a) |
|
42844 NM_142947.3 NP_651204.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
EMB17066 |
mRNA adenosine methylase |
33(a) |
1 ↔ 1 |
4(6619817-6623351) |
rice
(Oryza sativa) |
Liliopsida |
-- |
MT-A70 domain containing protein, expressed |
34(a) |
1 ↔ 1 |
2(27354548-27359931) |
ENSEMBL Gene Tree for METTL3 (if available)
TreeFam Gene Tree for METTL3 (if available) |
Paralogs
for METTL3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for METTL3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for METTL3 (21966191 - 21979517 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for METTL3
2 CNVs: 5727 5318 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing METTL3 |
|
Disorders
/ Diseases
for METTL3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
METTL3 for disorders About GeneDecksing
OMIM gene information: 612472
OMIM disorders: --
4  diseases for METTL3: About MalaCardsaicardi syndrome homocysteine malaria prostatitis
Export disorders for METTL3 gene to outside databases
|
Publications
for METTL3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for METTL3 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with METTL3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
- Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase. (PubMed id 9409616)1, 2 Bokar J.A.... Rottman F.M. (1997)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
|
External Searches for METTL3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing METTL3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing METTL3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing METTL3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for METTL3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for METTL3 gene:
Search GeneIP for patents involving METTL3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for METTL3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for METTL3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for METTL3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for METTL3 | | | OriGene Protein Over-expression Lysate for METTL3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for METTL3 | | OriGene 3'-UTR Clone for METTL3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for METTL3 | | OriGene Custom Protein Services for METTL3 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat METTL3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing METTL3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat METTL3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL3 |
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| | | | Search Tocris compounds for METTL3 |
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 | | | METTL3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL3 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for METTL3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL3 |
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