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METTL3 Gene

protein-coding   GIFtS: 55
GCID: GC14M021966

Methyltransferase Like 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Methyltransferase Like 31 2     M6A2
N6-Adenosine-Methyltransferase 70 KDa Subunit1 2     Spo82
Methyltransferase-Like Protein 32 3     AdoMet-Binding Subunit Of The Human MRNA (N6-Adenosine)-Methyltransferase2
MT-A702 3     MRNA M(6)A Methyltransferase2
EC 2.1.1.623 8     MTA703
IME42 5     

External Ids:    HGNC: 175631   Entrez Gene: 563392   Ensembl: ENSG000001658197   OMIM: 6124725   UniProtKB: Q86U443   

Export aliases for METTL3 gene to outside databases

Previous GC identifers: GC14M015753 GC14M019956 GC14M021036 GC14U900552 GC14M002084


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for METTL3 Gene:
This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is
involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming
N6-methyladenosine. (provided by RefSeq, Jul 2008)

GeneCards Summary for METTL3 Gene:
METTL3 (methyltransferase like 3) is a protein-coding gene. GO annotations related to this gene include mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity and RNA binding.

UniProtKB/Swiss-Prot: MTA70_HUMAN, Q86U44
Function: N6-methyltransferase that methylates adenosine residues of some mRNAs and acts as a regulator of the
circadian clock. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs,
plays a role in the efficiency of mRNA splicing and processing. M6A regulates the length of the ciracadian clock:
acts as a early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating
nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop

Gene Wiki entry for METTL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the METTL3 gene promoter:
         GR   RP58   SREBP-1c   MyoD   c-Ets-1   SREBP-1b   CREB   SREBP-1a   deltaCREB   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMETTL3 promoter sequence
   Search Chromatin IP Primers for METTL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat METTL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.1   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.1

METTL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
METTL3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M021966:  view genomic region     (about GC identifiers)

Start:
21,966,277 bp from pter      End:
21,979,517 bp from pter
Size:
13,241 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MTA70_HUMAN, Q86U44 (See protein sequence)
Recommended Name: N6-adenosine-methyltransferase 70 kDa subunit  
Size: 580 amino acids; 64474 Da
Secondary accessions: O14736 Q86V05 Q9HB32
Alternative splicing: 2 isoforms:  Q86U44-1   Q86U44-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for METTL3: NX_Q86U44

Explore proteomics data for METTL3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys459, Lys488
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for METTL3 (Q86U44)
     TCKYVHYE  FLWVTGRAMELGRECL 


    See METTL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_062826.2  
    ENSEMBL proteins: 
     ENSP00000440598   ENSP00000298717   ENSP00000442407   ENSP00000445523   ENSP00000437692  
     ENSP00000366766   ENSP00000442316  
    Reactome Protein details: Q86U44

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    Cloud-Clone Corp. Proteins for METTL3

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR007757 MT-A70-like
     IPR025848 MT-A70

    Graphical View of Domain Structure for InterPro Entry Q86U44

    ProtoNet protein and cluster: Q86U44

    1 Blocks protein domain: IPB007757 MT-A70

    UniProtKB/Swiss-Prot: MTA70_HUMAN, Q86U44
    Similarity: Belongs to the MT-A70-like family


    Find genes that share domains with METTL3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTA70_HUMAN, Q86U44
    Function: N6-methyltransferase that methylates adenosine residues of some mRNAs and acts as a regulator of the
    circadian clock. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs,
    plays a role in the efficiency of mRNA splicing and processing. M6A regulates the length of the ciracadian clock:
    acts as a early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating
    nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop
    Catalytic activity: S-adenosyl-L-methionine + m(7)G(5')pppAm = S-adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am

         Enzyme Number (IUBMB): EC 2.1.1.621 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0008168methyltransferase activity ----
    GO:0016422mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity IMP--
         
    Find genes that share ontologies with METTL3           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MTA70_HUMAN, Q86U44: Nucleus speckle. Note=Colocalizes with speckles in interphase nuclei. Suggesting that it may
    be associated with nuclear pre-mRNA splicing components
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9409616
    GO:0005654nucleoplasm TAS--
    GO:0016607nuclear speck IEA--

    Find genes that share ontologies with METTL3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for METTL3 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA processing0.44
    2Gene Expression
    Gene Expression0.40


    Find genes that share SuperPaths with METTL3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for METTL3
        mRNA processing

    1 Reactome Pathway for METTL3
        Processing of Capped Intron-Containing Pre-mRNA


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for METTL3
    Interactions:

        Search GeneGlobe Interaction Network for METTL3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for METTL3 (Q86U443 ENSP000003667664) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    METTL14Q9HCE53I2D: score=5 
    AGAP3Q96P473I2D: score=3 
    --ensp: ENSP000002987174STRING: ensp: ENSP00000298717
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001510RNA methylation IMP9409616
    GO:0006139nucleobase-containing compound metabolic process ----
    GO:0006397mRNA processing ISS--
    GO:0007623circadian rhythm ISS--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with METTL3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for METTL3 (MTA70)

    3 HMDB Compounds for METTL3    About this table
    CompoundSynonyms CAS #PubMed Ids
    N6-MethyladenosineN-methyladenosine (see all 9)1867-73-8--
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for METTL3 gene: 
    NM_019852.3  

    Unigene Cluster for METTL3:

    Methyltransferase like 3
    Hs.168799  [show with all ESTs]
    Unigene Representative Sequence: AK097873
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000539760 ENST00000298717(uc001wbc.3) ENST00000544500(uc001wbb.3)
    ENST00000396522 ENST00000537163(uc010tlw.1) ENST00000543235 ENST00000544248
    ENST00000536201(uc010tlx.2) ENST00000542054(uc021rox.1) ENST00000539910
    ENST00000377543 ENST00000367606 ENST00000545319 ENST00000545788 ENST00000538267

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      QuantiTect SYBR Green Assays in human, mouse, rat METTL3
      QuantiFast Probe-based Assays in human, mouse, rat METTL3

    Additional mRNA sequence: 

    AK000222.1 AK093509.1 AK097873.1 AK098655.1 AK124183.1 AK300289.1 AK304251.1 AK304570.1 
    BC001650.2 BC003031.1 BC014427.1 BC052244.1 BX247964.1 

    Selected DOTS entries (see all 30):

    DT.100879717  DT.40282672  DT.91974604  DT.100702386  DT.120763185  DT.100806117  DT.97859872  DT.100879718 
    DT.100879708  DT.100879710  DT.120763138  DT.40109746  DT.40132729  DT.100879707  DT.120763112  DT.120763170 
    DT.95165100  DT.100879701  DT.100879715  DT.95132862  DT.100037293  DT.120763103  DT.120763183  DT.120763142 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for METTL3 (see all 16)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                  -     -     -                 -                           
    SP3:                                                                                                                                -                           
    SP4:                                -     -     -     -     -     -                                   -     -     -                 -     -                     
    SP5:                                -     -     -     -     -     -                                   -     -     -                 -                           

    ExUns: 11b · 11c · 11d ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for METTL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    METTL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTCTGTAAG
    METTL3 Expression
    About this image


    METTL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
    METTL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    METTL3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.168799

    UniProtKB/Swiss-Prot: MTA70_HUMAN, Q86U44
    Tissue specificity: Widely expressed at low level. Expressed in spleen, thymus, prostate, testis, ovary, small
    intestine, colon and peripheral blood leukocytes

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for METTL3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mettl31 , 5 methyltransferase like 31, 5 90.06(n)1
    97.07(a)1
      14 (26.88 cM)5
    563351  NM_019721.21  NP_062695.21 
     522946685 
    lizard
    (Anolis carolinensis)
    Reptilia METTL36
    methyltransferase like 3
    88(a)
    1 ↔ 1
    GL343466.1(480366-493852)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mettl31 methyltransferase like 3 71.96(n)
    80.25(a)
      549173  NM_001016419.2  NP_001016419.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mettl31 methyltransferase like 3 65.96(n)
    71.88(a)
      100004398  NM_212780.1  NP_997945.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ime41 Inducer of meiosis 4 56.1(n)
    53.21(a)
      42844  NM_142947.3  NP_651204.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes IME4(YGL192W)4 Probable mRNA N6-adenosine methyltransferase required more   --   7(142246-144048) 852683  NP_011323.1 


    ENSEMBL Gene Tree for METTL3 (if available)
    TreeFam Gene Tree for METTL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for METTL3 (see all 291)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
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    ----------
    rs1869112681,2
    C--21967884(+) CAAAAA/GAAAGC 1 -- int10--------
    rs11391301,2
    C,F,H--21967916(+) CAGAGA/GTTTAG 2 N syn136Minor allele frequency- G:0.49MN EA NA NS WA CSA EU 10531
    rs2012645951,2
    C--21967946(+) ATGGCC/TCTAGA 2 R syn10--------
    rs1907542321,2
    --21968059(+) TGAACA/GTTTAC 1 -- int10--------
    rs1826733251,2
    --21968072(+) GCACAC/TCACCA 1 -- int10--------
    rs1858607551,2
    --21968175(+) GGGTAA/GAATTT 1 -- int10--------
    rs1430740131,2
    --21968203(+) TAGGAA/CTCAGT 1 -- int10--------
    rs1511813981,2
    C--21968246(+) CGCCTA/GTAATC 1 -- int10--------
    rs1896896251,2
    --21968319(+) TAACAC/TGGTGA 1 -- int10--------
    rs799631341,2
    C--21968390(+) GTAATA/CCCAGC 1 -- int10--------

    HapMap Linkage Disequilibrium report for METTL3 (21966277 - 21979517 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for METTL3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422459CNV Duplication17116639
    nsv85879CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing METTL3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612472    OMIM disorders: --


    Find genes that share disorders with METTL3           About GenesLikeMe

    Genetic Association Database (GAD): METTL3

    Export disorders for METTL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for METTL3 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with METTL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (Nature 2003)
    4. Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase. (PubMed id 9409616)1, 2 Bokar J.A.... Rottman F.M. (RNA 1997)
    5. N-methyladenosine-dependent regulation of messenger RNA stability. (PubMed id 24284625)2 Wang X.... He C. (Nature 2014)
    6. RNA-methylation-dependent RNA processing controls the speed of the circadian clock. (PubMed id 24209618)1 Fustin J.M....Okamura H. (Cell 2013)
    7. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Topology of the human and mouse m6A RNA methylomes revealed by m6A- seq. (PubMed id 22575960)2 Dominissini D.... Rechavi G. (Nature 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 56339 HGNC: 17563 Ensembl:ENSG00000165819 euGenes: HUgn56339 ECgene: METTL3
    H-InvDB: METTL3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for METTL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for METTL3 gene:
    Search GeneIP for patents involving METTL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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