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Aliases for METTL3 Gene

Aliases for METTL3 Gene

  • Methyltransferase Like 3 2 3 5
  • MRNA (2-O-Methyladenosine-N(6)-)-Methyltransferase 2 3
  • N6-Adenosine-Methyltransferase 70 KDa Subunit 2 3
  • Methyltransferase-Like Protein 3 3 4
  • EC 2.1.1.62 4 58
  • HMETTL3 3 4
  • MT-A70 3 4
  • AdoMet-Binding Subunit Of The Human MRNA (N6-Adenosine)-Methyltransferase 3
  • MRNA M(6)A Methyltransferase 3
  • MTA70 4
  • IME4 3
  • Spo8 3
  • M6A 3

External Ids for METTL3 Gene

Previous GeneCards Identifiers for METTL3 Gene

  • GC14M015753
  • GC14M019956
  • GC14M021036
  • GC14U900552
  • GC14M021966
  • GC14M002084

Summaries for METTL3 Gene

Entrez Gene Summary for METTL3 Gene

  • This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine. [provided by RefSeq, Jul 2008]

GeneCards Summary for METTL3 Gene

METTL3 (Methyltransferase Like 3) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Circadian rythm related genes. GO annotations related to this gene include RNA binding and mRNA (2-O-methyladenosine-N6-)-methyltransferase activity.

UniProtKB/Swiss-Prot for METTL3 Gene

  • The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues of some RNAs and regulates the circadian clock, differentiation of embryonic stem cells and primary miRNA processing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:27373337, PubMed:27281194, PubMed:9409616). In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core (PubMed:27373337, PubMed:27281194). N6-methyladenosine (m6A), which takes place at the 5-[AG]GAC-3 consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing, processing, translation efficiency, editing and mRNA stability (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:9409616). M6A regulates the length of the circadian clock: acts as an early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A also acts as a regulator of mRNA stability: in embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). METTL3 also mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998). Acts as a positive regulator of mRNA translation independently of the methyltransferase activity: promotes translation by interacting with the translation initiation machinery in the cytoplasm (PubMed:27117702). Its overexpression in a number of cancer cells suggests that it may participate to cancer cell proliferation by promoting mRNA translation (PubMed:27117702).

Gene Wiki entry for METTL3 Gene

Additional gene information for METTL3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL3 Gene

Genomics for METTL3 Gene

Regulatory Elements for METTL3 Gene

Enhancers for METTL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H020657 1.3 Ensembl ENCODE 93.4 +853.6 853648 1 HDGF PKNOX1 SIN3A GLI4 ZNF2 GTF3C2 GLIS2 FOS KLF7 ZNF548 METTL3 SUPT16H METTL17 ENSG00000258515 CHD8 TEP1 ENSG00000258768 TTC5 PARP2 PIP4P1
GH14H021092 2 FANTOM5 Ensembl ENCODE dbSUPER 58.8 +409.9 409949 18 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A SSRP1 METTL3 SUPT16H CHD8 METTL17 APEX1 PNP TEP1 ARHGEF40 TOX4 SNORA79B
GH14H020679 1.9 FANTOM5 ENCODE dbSUPER 48.6 +826.8 826843 9 MLX ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC PPARGC1A SSRP1 ZNF610 METTL3 ENSG00000258515 SUPT16H CHD8 PARP2 TTC5 PIP4P1 METTL17 RNASE4 ENSG00000258768
GH14H020622 1.3 Ensembl ENCODE 64.6 +886.6 886627 3 HNRNPUL1 SIN3A FEZF1 ZNF2 ZNF143 FOS ZC3H11A ZNF592 SSRP1 ZNF610 METTL3 SUPT16H CHD8 PARP2 METTL17 ENSG00000258515 TEP1 ENSG00000258768 OSGEP TOX4
GH14H021263 1.6 Ensembl ENCODE dbSUPER 52.1 +244.3 244321 7 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SUPT16H METTL3 CHD8 METTL17 HNRNPC ENSG00000258515 PIP4P1 RAB2B APEX1 TRAV8-5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around METTL3 on UCSC Golden Path with GeneCards custom track

Promoters for METTL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000066491 175 2000 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for METTL3 Gene

Chromosome:
14
Start:
21,498,131 bp from pter
End:
21,511,375 bp from pter
Size:
13,245 bases
Orientation:
Minus strand

Genomic View for METTL3 Gene

Genes around METTL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL3 Gene

Proteins for METTL3 Gene

  • Protein details for METTL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86U44-MTA70_HUMAN
    Recommended name:
    N6-adenosine-methyltransferase 70 kDa subunit
    Protein Accession:
    Q86U44
    Secondary Accessions:
    • O14736
    • Q86V05
    • Q9HB32

    Protein attributes for METTL3 Gene

    Size:
    580 amino acids
    Molecular mass:
    64474 Da
    Quaternary structure:
    • Heterodimer; heterodimerizes with METTL14 to form an antiparallel heterodimer that constitutes an active methyltransferase (PubMed:27373337, PubMed:27281194). Component of the WMM complex, a N6-methyltransferase complex composed of WTAP, METTL3 and METTL14 (PubMed:24407421, PubMed:24981863). Interacts with NCBP1/CBP80 (PubMed:27117702). Interacts with EIF4E (PubMed:27117702). Interacts with EIF3B (PubMed:27117702).

    Three dimensional structures from OCA and Proteopedia for METTL3 Gene

    Alternative splice isoforms for METTL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for METTL3 Gene

Selected DME Specific Peptides for METTL3 Gene

Q86U44:
  • FLWVTGRAMELGRECL
  • TCKYVHYE

Post-translational modifications for METTL3 Gene

  • Ubiquitination at Lys459 and posLast=488488
  • Modification sites at PhosphoSitePlus

Other Protein References for METTL3 Gene

Domains & Families for METTL3 Gene

Gene Families for METTL3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for METTL3 Gene

Graphical View of Domain Structure for InterPro Entry

Q86U44

UniProtKB/Swiss-Prot:

MTA70_HUMAN :
  • Gate loop 1 and gate loop 2 regions are adjacent to the S-adenosyl-L-homocysteine-binding site and display large conformational changes upon ligand-binding. They may play an important role in adenosine recognition. The interface loop contributes to the heterodimer interaction.
  • Belongs to the MT-A70-like family.
Domain:
  • Gate loop 1 and gate loop 2 regions are adjacent to the S-adenosyl-L-homocysteine-binding site and display large conformational changes upon ligand-binding. They may play an important role in adenosine recognition. The interface loop contributes to the heterodimer interaction.
Family:
  • Belongs to the MT-A70-like family.
genes like me logo Genes that share domains with METTL3: view

Function for METTL3 Gene

Molecular function for METTL3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + m(7)G(5)pppAm = S-adenosyl-L-homocysteine + m(7)G(5)pppm(6)Am.
UniProtKB/Swiss-Prot EnzymeRegulation:
Methyltransferase activity is regulated by miRNAs via a sequence pairing mechanism.
UniProtKB/Swiss-Prot Function:
The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues of some RNAs and regulates the circadian clock, differentiation of embryonic stem cells and primary miRNA processing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:27373337, PubMed:27281194, PubMed:9409616). In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core (PubMed:27373337, PubMed:27281194). N6-methyladenosine (m6A), which takes place at the 5-[AG]GAC-3 consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing, processing, translation efficiency, editing and mRNA stability (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:9409616). M6A regulates the length of the circadian clock: acts as an early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A also acts as a regulator of mRNA stability: in embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). METTL3 also mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998). Acts as a positive regulator of mRNA translation independently of the methyltransferase activity: promotes translation by interacting with the translation initiation machinery in the cytoplasm (PubMed:27117702). Its overexpression in a number of cancer cells suggests that it may participate to cancer cell proliferation by promoting mRNA translation (PubMed:27117702).
UniProtKB/Swiss-Prot Induction:
Overexpressed in a number of cancer tissues, such as lung adenocarcinoma and colon adenocarcinoma (PubMed:27117702).

Enzyme Numbers (IUBMB) for METTL3 Gene

Phenotypes From GWAS Catalog for METTL3 Gene

Gene Ontology (GO) - Molecular Function for METTL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0003729 mRNA binding IDA 27281194
GO:0008168 methyltransferase activity IEA --
GO:0008173 RNA methyltransferase activity IDA 25799998
GO:0016422 mRNA (2-O-methyladenosine-N6-)-methyltransferase activity IEA,IMP 9409616
genes like me logo Genes that share ontologies with METTL3: view
genes like me logo Genes that share phenotypes with METTL3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for METTL3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for METTL3 Gene

Localization for METTL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL3 Gene

Nucleus. Nucleus speckle. Cytoplasm. Note=Colocalizes with speckles in interphase nuclei. Suggesting that it may be associated with nuclear pre-mRNA splicing components. {ECO:0000269 PubMed:9409616}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL3 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for METTL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 9409616
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0016607 nuclear speck IDA,IEA 24407421
GO:0036396 MIS complex IDA 24316715
genes like me logo Genes that share ontologies with METTL3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for METTL3 Gene

Pathways & Interactions for METTL3 Gene

genes like me logo Genes that share pathways with METTL3: view

Pathways by source for METTL3 Gene

1 Cell Signaling Technology pathway for METTL3 Gene
2 BioSystems pathways for METTL3 Gene

Gene Ontology (GO) - Biological Process for METTL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IMP 25719671
GO:0001510 RNA methylation IMP,IEA 9409616
GO:0006139 nucleobase-containing compound metabolic process IEA --
GO:0006382 adenosine to inosine editing ISS --
GO:0006397 mRNA processing ISS --
genes like me logo Genes that share ontologies with METTL3: view

No data available for SIGNOR curated interactions for METTL3 Gene

Drugs & Compounds for METTL3 Gene

(1) Drugs for METTL3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
s-adenosylhomocysteine Experimental Pharma 0

(2) Additional Compounds for METTL3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N6-Methyladenosine
  • 6-Methyladenosine
  • 6-Methylamino-9-beta-D-ribofuranosyl-Purine
  • 6-Methylamino-9-beta-delta-ribofuranosyl-Purine
  • 6-Methylaminopurine D-riboside
  • 6-Methylaminopurine ribonucleoside
1867-73-8
s-adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
  • 2-S-Adenosyl-L-methionine
  • 5'-Deoxyadenosine-5'-L-methionine disulfate ditosylate
  • 5'-Deoxyadenosine-5'-L-methionine disulphate ditosylate
  • Active methionine
29908-03-0
genes like me logo Genes that share compounds with METTL3: view

Transcripts for METTL3 Gene

mRNA/cDNA for METTL3 Gene

(3) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for METTL3 Gene

Methyltransferase like 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for METTL3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for METTL3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a ·
SP1:
SP2: - - - -
SP3: -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6:
SP7: - - - - - - -
SP8: - - - - - - -
SP9: -
SP10: - - - - - -
SP11: - - - - - -
SP12: - - - - - -
SP13:
SP14: - - - - - -
SP15: -
SP16: - - - -

ExUns: 11b · 11c · 11d ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for METTL3 Gene

GeneLoc Exon Structure for
METTL3
ECgene alternative splicing isoforms for
METTL3

Expression for METTL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for METTL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for METTL3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.6) and CD8 Tcells (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for METTL3 Gene



Protein tissue co-expression partners for METTL3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of METTL3 Gene:

METTL3

SOURCE GeneReport for Unigene cluster for METTL3 Gene:

Hs.168799

mRNA Expression by UniProt/SwissProt for METTL3 Gene:

Q86U44-MTA70_HUMAN
Tissue specificity: Widely expressed at low level. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for METTL3 Gene

  • Nervous system(4.6)
  • Lung(4.5)
  • Liver(4.2)
  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with METTL3: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL3 Gene

Orthologs for METTL3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for METTL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL3 33 34
  • 99.66 (n)
cow
(Bos Taurus)
Mammalia METTL3 33 34
  • 94.25 (n)
dog
(Canis familiaris)
Mammalia METTL3 33 34
  • 94.2 (n)
rat
(Rattus norvegicus)
Mammalia Mettl3 33
  • 90.4 (n)
mouse
(Mus musculus)
Mammalia Mettl3 33 16 34
  • 90.06 (n)
oppossum
(Monodelphis domestica)
Mammalia METTL3 34
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia METTL3 34
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl3 33
  • 71.96 (n)
zebrafish
(Danio rerio)
Actinopterygii mettl3 33 34
  • 65.96 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ime4 33 34
  • 56.1 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002895 33
  • 54.53 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IME4 34 36
  • 30 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1577 34
  • 50 (a)
OneToOne
Species where no ortholog for METTL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for METTL3 Gene

ENSEMBL:
Gene Tree for METTL3 (if available)
TreeFam:
Gene Tree for METTL3 (if available)

Paralogs for METTL3 Gene

No data available for Paralogs for METTL3 Gene

Variants for METTL3 Gene

Sequence variations from dbSNP and Humsavar for METTL3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000165463 -- 21,505,465(+) TATTA(A/G)TAACA intron-variant
rs1000174585 -- 21,510,483(+) AGTGA(A/T)TTTAA intron-variant
rs1000219668 -- 21,505,790(+) GCCTC(C/T)GCTCT intron-variant
rs1000373945 -- 21,498,838(+) TAGAA(C/T)CTGTT intron-variant, utr-variant-3-prime
rs1000723956 -- 21,498,492(+) AAAAA(A/G)AGCTT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for METTL3 Gene

Variant ID Type Subtype PubMed ID
esv2422459 CNV duplication 17116639
esv3633716 CNV gain 21293372
esv3633718 CNV gain 21293372
nsv85879 CNV deletion 16902084

Variation tolerance for METTL3 Gene

Residual Variation Intolerance Score: 47.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.84; 34.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for METTL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
METTL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL3 Gene

Disorders for METTL3 Gene

Relevant External Links for METTL3

Genetic Association Database (GAD)
METTL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
METTL3

No disorders were found for METTL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL3 Gene

Publications for METTL3 Gene

  1. Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex. (PMID: 27281194) Wang X … Yin P (Nature 2016) 3 4 60
  2. Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases. (PMID: 27373337) Wang P … Nam Y (Molecular cell 2016) 3 4 60
  3. The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells. (PMID: 27117702) Lin S … Gregory RI (Molecular cell 2016) 3 4 60
  4. N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions. (PMID: 25719671) Liu N … Pan T (Nature 2015) 3 4 60
  5. Dynamic m(6)A mRNA methylation directs translational control of heat shock response. (PMID: 26458103) Zhou J … Qian SB (Nature 2015) 3 4 60

Products for METTL3 Gene

Sources for METTL3 Gene

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