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Aliases for METTL3 Gene

Aliases for METTL3 Gene

  • Methyltransferase Like 3 2 3
  • MRNA (2-O-Methyladenosine-N(6)-)-Methyltransferase 2 3
  • N6-Adenosine-Methyltransferase 70 KDa Subunit 2 3
  • Methyltransferase-Like Protein 3 3 4
  • EC 2.1.1.62 4 63
  • MT-A70 3 4
  • IME4 3 6
  • AdoMet-Binding Subunit Of The Human MRNA (N6-Adenosine)-Methyltransferase 3
  • MRNA M(6)A Methyltransferase 3
  • MTA70 4
  • Spo8 3
  • M6A 3

External Ids for METTL3 Gene

Previous GeneCards Identifiers for METTL3 Gene

  • GC14M015753
  • GC14M019956
  • GC14M021036
  • GC14U900552
  • GC14M021966
  • GC14M002084

Summaries for METTL3 Gene

Entrez Gene Summary for METTL3 Gene

  • This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine. [provided by RefSeq, Jul 2008]

GeneCards Summary for METTL3 Gene

METTL3 (Methyltransferase Like 3) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include RNA binding and mRNA (2-O-methyladenosine-N6-)-methyltransferase activity.

UniProtKB/Swiss-Prot for METTL3 Gene

  • N6-methyltransferase that methylates adenosine residues of some mRNAs and acts as a regulator of the circadian clock and differentiation of embryonic stem cells. N6-methyladenosine (m6A), which takes place at the 5-[AG]GAC-3 consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing, processing, editing and mRNA stability (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:9409616). M6A regulates the length of the circadian clock: acts as a early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A also acts as a regulator of mRNA stability: in embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity).

Gene Wiki entry for METTL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL3 Gene

Genomics for METTL3 Gene

Regulatory Elements for METTL3 Gene

Genomic Location for METTL3 Gene

Start:
21,498,133 bp from pter
End:
21,511,375 bp from pter
Size:
13,243 bases
Orientation:
Minus strand

Genomic View for METTL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for METTL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL3 Gene

Proteins for METTL3 Gene

  • Protein details for METTL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86U44-MTA70_HUMAN
    Recommended name:
    N6-adenosine-methyltransferase 70 kDa subunit
    Protein Accession:
    Q86U44
    Secondary Accessions:
    • O14736
    • Q86V05
    • Q9HB32

    Protein attributes for METTL3 Gene

    Size:
    580 amino acids
    Molecular mass:
    64474 Da
    Quaternary structure:
    • Component of the WMM complex, a N6-methyltransferase complex composed of WTAP, METTL3 and METTL14.

    Alternative splice isoforms for METTL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for METTL3 Gene

Proteomics data for METTL3 Gene at MOPED

Selected DME Specific Peptides for METTL3 Gene

Post-translational modifications for METTL3 Gene

  • Ubiquitination at Lys459 and Lys488
  • Modification sites at PhosphoSitePlus

Other Protein References for METTL3 Gene

Domains for METTL3 Gene

Protein Domains for METTL3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q86U44

UniProtKB/Swiss-Prot:

MTA70_HUMAN :
  • Q86U44
Family:
  • Belongs to the MT-A70-like family.
genes like me logo Genes that share domains with METTL3: view

No data available for Gene Families for METTL3 Gene

Function for METTL3 Gene

Molecular function for METTL3 Gene

UniProtKB/Swiss-Prot CatalyticActivity: S-adenosyl-L-methionine + m(7)G(5)pppAm = S-adenosyl-L-homocysteine + m(7)G(5)pppm(6)Am.
UniProtKB/Swiss-Prot EnzymeRegulation: Methyltransferase activity is regulated by miRNAs via a sequence pairing mechanism.
UniProtKB/Swiss-Prot Function: N6-methyltransferase that methylates adenosine residues of some mRNAs and acts as a regulator of the circadian clock and differentiation of embryonic stem cells. N6-methyladenosine (m6A), which takes place at the 5-[AG]GAC-3 consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing, processing, editing and mRNA stability (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:9409616). M6A regulates the length of the circadian clock: acts as a early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A also acts as a regulator of mRNA stability: in embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity).

Enzyme Numbers (IUBMB) for METTL3 Gene

Gene Ontology (GO) - Molecular Function for METTL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding --
GO:0008168 methyltransferase activity --
GO:0016422 mRNA (2-O-methyladenosine-N6-)-methyltransferase activity IMP 22575960
genes like me logo Genes that share ontologies with METTL3: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for METTL3 Gene

Localization for METTL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL3 Gene

Nucleus speckle. Note=Colocalizes with speckles in interphase nuclei. Suggesting that it may be associated with nuclear pre-mRNA splicing components. {ECO:0000269 PubMed:9409616}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for METTL3 Gene COMPARTMENTS Subcellular localization image for METTL3 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for METTL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 24316715
GO:0005654 nucleoplasm TAS --
GO:0016607 nuclear speck IDA 24407421
GO:0036396 MIS complex IDA 24316715
genes like me logo Genes that share ontologies with METTL3: view

Pathways for METTL3 Gene

genes like me logo Genes that share pathways with METTL3: view

Pathways by source for METTL3 Gene

1 BioSystems pathway for METTL3 Gene

Interacting Proteins for METTL3 Gene

Gene Ontology (GO) - Biological Process for METTL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome ISS --
GO:0001510 RNA methylation IMP 9409616
GO:0006139 nucleobase-containing compound metabolic process --
GO:0006382 adenosine to inosine editing ISS --
GO:0006397 mRNA processing ISS --
genes like me logo Genes that share ontologies with METTL3: view

Compounds for METTL3 Gene

(3) HMDB Compounds for METTL3 Gene

Compound Synonyms Cas Number PubMed IDs
N6-Methyladenosine
  • N-methyladenosine
1867-73-8
S-Adenosylhomocysteine
  • (S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine
979-92-0
S-Adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
29908-03-0
genes like me logo Genes that share compounds with METTL3: view

Transcripts for METTL3 Gene

mRNA/cDNA for METTL3 Gene

(13) Additional mRNA sequences :
(4) REFSEQ mRNAs :
(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for METTL3 Gene

Methyltransferase like 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for METTL3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a ·
SP1:
SP2: - - - -
SP3: -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6:
SP7: - - - - - - -
SP8: - - - - - - -
SP9: -
SP10: - - - - - -
SP11: - - - - - -
SP12: - - - - - -
SP13:
SP14: - - - - - -
SP15: -
SP16: - - - -

ExUns: 11b · 11c · 11d ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for METTL3 Gene

GeneLoc Exon Structure for
METTL3
ECgene alternative splicing isoforms for
METTL3

Expression for METTL3 Gene

mRNA expression in normal human tissues for METTL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for METTL3 Gene

SOURCE GeneReport for Unigene cluster for METTL3 Gene Hs.168799

mRNA Expression by UniProt/SwissProt for METTL3 Gene

Q86U44-MTA70_HUMAN
Tissue specificity: Widely expressed at low level. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes.
genes like me logo Genes that share expressions with METTL3: view

No data available for mRNA differential expression in normal tissues for METTL3 Gene

Orthologs for METTL3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for METTL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL3 35
  • 99.66 (n)
  • 100 (a)
METTL3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia METTL3 35
  • 94.25 (n)
  • 97.76 (a)
METTL3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia METTL3 35
  • 94.2 (n)
  • 98.45 (a)
METTL3 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mettl3 35
  • 90.06 (n)
  • 97.07 (a)
Mettl3 16
Mettl3 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia METTL3 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mettl3 35
  • 90.4 (n)
  • 96.72 (a)
lizard
(Anolis carolinensis)
Reptilia METTL3 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl3 35
  • 71.96 (n)
  • 80.25 (a)
zebrafish
(Danio rerio)
Actinopterygii mettl3 35
  • 65.96 (n)
  • 71.88 (a)
mettl3 36
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002895 35
  • 54.53 (n)
  • 52.75 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ime4 35
  • 56.1 (n)
  • 53.21 (a)
Ime4 36
  • 47 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IME4 36
  • 30 (a)
OneToOne
IME4 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1577 36
  • 50 (a)
OneToOne
Species with no ortholog for METTL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for METTL3 Gene

ENSEMBL:
Gene Tree for METTL3 (if available)
TreeFam:
Gene Tree for METTL3 (if available)

Paralogs for METTL3 Gene

No data available for Paralogs for METTL3 Gene

Variants for METTL3 Gene

Sequence variations from dbSNP and Humsavar for METTL3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs719785 -- 21,510,151(+) CTTGA(A/G)TCCTA intron-variant
rs966602 -- 21,502,269(+) TCCTC(A/G)CGCCT intron-variant
rs1139130 -- 21,499,772(+) CAGAG(A/G)TTTAG reference, synonymous-codon
rs1263790 -- 21,500,477(+) CCTAC(A/G)TAACT intron-variant
rs1263791 -- 21,501,530(+) AAAAA(A/T)CTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for METTL3 Gene

Variant ID Type Subtype PubMed ID
esv2422459 CNV Duplication 17116639
nsv85879 CNV Loss 16902084

Relevant External Links for METTL3 Gene

HapMap Linkage Disequilibrium report
METTL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL3 Gene

Disorders for METTL3 Gene

Relevant External Links for METTL3

Genetic Association Database (GAD)
METTL3
genes like me logo Genes that share disorders with METTL3: view

No data available for UniProtKB/Swiss-Prot for METTL3 Gene

Publications for METTL3 Gene

  1. Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase. (PMID: 9409616) Bokar J.A. … Rottman F.M. (RNA 1997) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4
  4. A METTL3-METTL14 complex mediates mammalian nuclear RNA N-adenosine methylation. (PMID: 24316715) Liu J. … He C. (Nat. Chem. Biol. 2014) 2 3
  5. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. (PMID: 24407421) Ping X.L. … Yang Y.G. (Cell Res. 2014) 3 4

Products for METTL3 Gene

Sources for METTL3 Gene

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