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Aliases for METTL3 Gene

Aliases for METTL3 Gene

  • Methyltransferase Like 3 2 3
  • MRNA (2-O-Methyladenosine-N(6)-)-Methyltransferase 2 3
  • Methyltransferase-Like Protein 3 3 4
  • EC 2.1.1.62 4 63
  • MT-A70 3 4
  • AdoMet-Binding Subunit Of The Human MRNA (N6-Adenosine)-Methyltransferase 3
  • N6-Adenosine-Methyltransferase 70 KDa Subunit 2
  • MRNA M(6)A Methyltransferase 3
  • MTA70 4
  • IME4 3
  • Spo8 3
  • M6A 3

External Ids for METTL3 Gene

Previous GeneCards Identifiers for METTL3 Gene

  • GC14M015753
  • GC14M019956
  • GC14M021036
  • GC14U900552
  • GC14M021966
  • GC14M002084

Summaries for METTL3 Gene

Entrez Gene Summary for METTL3 Gene

  • This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine. [provided by RefSeq, Jul 2008]

GeneCards Summary for METTL3 Gene

METTL3 (Methyltransferase Like 3) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include RNA binding and mRNA (2-O-methyladenosine-N6-)-methyltransferase activity.

UniProtKB/Swiss-Prot for METTL3 Gene

  • N6-methyltransferase that methylates adenosine residues of some RNAs and acts as a regulator of the circadian clock, differentiation of embryonic stem cells and primary miRNA processing. N6-methyladenosine (m6A), which takes place at the 5-[AG]GAC-3 consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing, processing, editing and mRNA stability (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:9409616). M6A regulates the length of the circadian clock: acts as a early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A also acts as a regulator of mRNA stability: in embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). Mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998).

Gene Wiki entry for METTL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL3 Gene

Genomics for METTL3 Gene

Regulatory Elements for METTL3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for METTL3 Gene

Chromosome:
14
Start:
21,498,131 bp from pter
End:
21,511,375 bp from pter
Size:
13,245 bases
Orientation:
Minus strand

Genomic View for METTL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for METTL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL3 Gene

Proteins for METTL3 Gene

  • Protein details for METTL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86U44-MTA70_HUMAN
    Recommended name:
    N6-adenosine-methyltransferase 70 kDa subunit
    Protein Accession:
    Q86U44
    Secondary Accessions:
    • O14736
    • Q86V05
    • Q9HB32

    Protein attributes for METTL3 Gene

    Size:
    580 amino acids
    Molecular mass:
    64474 Da
    Quaternary structure:
    • Component of the WMM complex, a N6-methyltransferase complex composed of WTAP, METTL3 and METTL14.

    Alternative splice isoforms for METTL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for METTL3 Gene

Proteomics data for METTL3 Gene at MOPED

Selected DME Specific Peptides for METTL3 Gene

Post-translational modifications for METTL3 Gene

  • Ubiquitination at Lys 459 and Lys 488
  • Modification sites at PhosphoSitePlus

Other Protein References for METTL3 Gene

Antibody Products

Domains & Families for METTL3 Gene

Gene Families for METTL3 Gene

Protein Domains for METTL3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q86U44

UniProtKB/Swiss-Prot:

MTA70_HUMAN :
  • Belongs to the MT-A70-like family.
Family:
  • Belongs to the MT-A70-like family.
genes like me logo Genes that share domains with METTL3: view

Function for METTL3 Gene

Molecular function for METTL3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + m(7)G(5)pppAm = S-adenosyl-L-homocysteine + m(7)G(5)pppm(6)Am.
UniProtKB/Swiss-Prot EnzymeRegulation:
Methyltransferase activity is regulated by miRNAs via a sequence pairing mechanism.
UniProtKB/Swiss-Prot Function:
N6-methyltransferase that methylates adenosine residues of some RNAs and acts as a regulator of the circadian clock, differentiation of embryonic stem cells and primary miRNA processing. N6-methyladenosine (m6A), which takes place at the 5-[AG]GAC-3 consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing, processing, editing and mRNA stability (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:9409616). M6A regulates the length of the circadian clock: acts as a early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A also acts as a regulator of mRNA stability: in embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). Mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998).

Enzyme Numbers (IUBMB) for METTL3 Gene

Gene Ontology (GO) - Molecular Function for METTL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0008168 methyltransferase activity --
GO:0008173 RNA methyltransferase activity IDA 25799998
GO:0016422 mRNA (2-O-methyladenosine-N6-)-methyltransferase activity IMP 9409616
genes like me logo Genes that share ontologies with METTL3: view

Phenotypes for METTL3 Gene

GenomeRNAi human phenotypes for METTL3:
genes like me logo Genes that share phenotypes with METTL3: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for METTL3

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for METTL3 Gene

Localization for METTL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL3 Gene

Nucleus speckle. Note=Colocalizes with speckles in interphase nuclei. Suggesting that it may be associated with nuclear pre-mRNA splicing components. {ECO:0000269 PubMed:9409616}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for METTL3 Gene COMPARTMENTS Subcellular localization image for METTL3 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for METTL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9409616
GO:0005654 nucleoplasm TAS --
GO:0016607 nuclear speck IDA 24407421
GO:0036396 MIS complex IDA 24316715
genes like me logo Genes that share ontologies with METTL3: view

Pathways & Interactions for METTL3 Gene

genes like me logo Genes that share pathways with METTL3: view

Pathways by source for METTL3 Gene

1 BioSystems pathway for METTL3 Gene

Interacting Proteins for METTL3 Gene

Gene Ontology (GO) - Biological Process for METTL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome ISS --
GO:0001510 RNA methylation IMP 9409616
GO:0006139 nucleobase-containing compound metabolic process --
GO:0006382 adenosine to inosine editing ISS --
GO:0006397 mRNA processing ISS --
genes like me logo Genes that share ontologies with METTL3: view

No data available for SIGNOR curated interactions for METTL3 Gene

Drugs & Compounds for METTL3 Gene

(2) Drugs for METTL3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma 0

(1) Additional Compounds for METTL3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N6-Methyladenosine
  • 6-Methyladenosine
  • 6-Methylamino-9-beta-D-ribofuranosyl-Purine
  • 6-Methylamino-9-beta-delta-ribofuranosyl-Purine
  • 6-Methylaminopurine D-riboside
  • 6-Methylaminopurine ribonucleoside
1867-73-8
genes like me logo Genes that share compounds with METTL3: view

Transcripts for METTL3 Gene

mRNA/cDNA for METTL3 Gene

(4) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for METTL3 Gene

Methyltransferase like 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for METTL3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a ·
SP1:
SP2: - - - -
SP3: -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6:
SP7: - - - - - - -
SP8: - - - - - - -
SP9: -
SP10: - - - - - -
SP11: - - - - - -
SP12: - - - - - -
SP13:
SP14: - - - - - -
SP15: -
SP16: - - - -

ExUns: 11b · 11c · 11d ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for METTL3 Gene

GeneLoc Exon Structure for
METTL3
ECgene alternative splicing isoforms for
METTL3

Expression for METTL3 Gene

mRNA expression in normal human tissues for METTL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for METTL3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.6) and CD8 Tcells (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for METTL3 Gene



SOURCE GeneReport for Unigene cluster for METTL3 Gene Hs.168799

mRNA Expression by UniProt/SwissProt for METTL3 Gene

Q86U44-MTA70_HUMAN
Tissue specificity: Widely expressed at low level. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with METTL3: view

Protein tissue co-expression partners for METTL3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for METTL3 Gene

Orthologs for METTL3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for METTL3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia METTL3 35
  • 94.25 (n)
  • 97.76 (a)
METTL3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia METTL3 35
  • 94.2 (n)
  • 98.45 (a)
METTL3 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mettl3 35
  • 90.06 (n)
  • 97.07 (a)
Mettl3 16
Mettl3 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia METTL3 35
  • 99.66 (n)
  • 100 (a)
METTL3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mettl3 35
  • 90.4 (n)
  • 96.72 (a)
oppossum
(Monodelphis domestica)
Mammalia METTL3 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia METTL3 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl3 35
  • 71.96 (n)
  • 80.25 (a)
zebrafish
(Danio rerio)
Actinopterygii mettl3 35
  • 65.96 (n)
  • 71.88 (a)
mettl3 36
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002895 35
  • 54.53 (n)
  • 52.75 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ime4 35
  • 56.1 (n)
  • 53.21 (a)
Ime4 36
  • 47 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IME4 36
  • 30 (a)
OneToOne
IME4 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1577 36
  • 50 (a)
OneToOne
Species with no ortholog for METTL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for METTL3 Gene

ENSEMBL:
Gene Tree for METTL3 (if available)
TreeFam:
Gene Tree for METTL3 (if available)

Paralogs for METTL3 Gene

No data available for Paralogs for METTL3 Gene

Variants for METTL3 Gene

Sequence variations from dbSNP and Humsavar for METTL3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs719785 -- 21,510,151(+) CTTGA(A/G)TCCTA intron-variant
rs966602 -- 21,502,269(+) TCCTC(A/G)CGCCT intron-variant
rs1139130 -- 21,499,772(+) CAGAG(A/G)TTTAG reference, synonymous-codon
rs1263790 -- 21,500,477(+) CCTAC(A/G)TAACT intron-variant
rs1263791 -- 21,501,530(+) AAAAA(A/T)CTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for METTL3 Gene

Variant ID Type Subtype PubMed ID
esv2422459 CNV Duplication 17116639
nsv85879 CNV Loss 16902084

Variation tolerance for METTL3 Gene

Residual Variation Intolerance Score: 47.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.84; 34.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for METTL3 Gene

HapMap Linkage Disequilibrium report
METTL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL3 Gene

Disorders for METTL3 Gene

Relevant External Links for METTL3

Genetic Association Database (GAD)
METTL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
METTL3
genes like me logo Genes that share disorders with METTL3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL3 Gene

Publications for METTL3 Gene

  1. A METTL3-METTL14 complex mediates mammalian nuclear RNA N-adenosine methylation. (PMID: 24316715) Liu J. … He C. (Nat. Chem. Biol. 2014) 2 67
  2. N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions. (PMID: 25719671) Liu N. … Pan T. (Nature 2015) 67
  3. N6-methyladenosine marks primary microRNAs for processing. (PMID: 25799998) Alarcon C.R. … Tavazoie S.F. (Nature 2015) 67
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  5. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. (PMID: 24407421) Ping X.L. … Yang Y.G. (Cell Res. 2014) 67

Products for METTL3 Gene

Sources for METTL3 Gene

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