METTL2B Gene
protein-coding GIFtS: 48
GCID: GC07P128108
|
|
methyltransferase like 2B(Previous name: methyltransferase like 2 )
(Previous symbol: METTL2)
| |
Aliases
for METTL2B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Methyltransferase Like 2B1 2 | | METTL2A2 | | METL1 2 | | PSENIP12 | | METTL21 2 | | Methyltransferase-Like Protein 2B2 | | FLJ113501 | | EC 2.1.1.-3 | | Methyltransferase Like 21 | | |
Export aliases for METTL2B gene to outside databasesPrevious GC identifers: GC07P127904 GC07P128098 GC07P128103 GC07P122477 GC07P128105 |
Summaries
for METTL2B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for METTL2B:
This gene is a member of a family of methyltransferases that share homology with, but are distinct from, the UbiEfamily of methyltransferases. Alternatively spliced variants which encode different protein isoforms have beendescribed; however, not all variants have been fully characterized. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: MET2B_HUMAN, Q6P1Q9Function: Probable methyltransferase (By similarity)
Gene Wiki entry for METTL2B
|
Genomic Views
for METTL2B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the METTL2B gene promoter:
NF-AT4 NF-AT2 AML1a FOXO4 NF-AT3 LyF-1 NF-AT1 NF-AT C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for METTL2B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL2B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q32.1 Ensembl cytogenetic band: 7q32.1 HGNC cytogenetic band: 7q32.2METTL2B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P128108: view genomic region
(about GC identifiers)
Start:
|
128,095,894 bp from pter |
End:
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128,146,656 bp from pter |
Size:
|
50,763 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 127,499,894-127,526,089 |
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Proteins
for METTL2B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MET2B_HUMAN, Q6P1Q9 (See
protein sequence)Recommended Name: Methyltransferase-like protein 2B Size: 378 amino acids; 43426 Da
Secondary accessions: B4DZ68 Q0IJ54 Q3B7J1Alternative splicing: 2 isoforms: Q6P1Q9-1 Q6P1Q9-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for METTL2B: NX_Q6P1Q9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6P1Q9
METTL2B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060866.2
ENSEMBL proteins: ENSP00000418634 ENSP00000262432 ENSP00000417616 ENSP00000418402 ENSP00000405144 ENSP00000418989
Human Recombinant Protein Products:
METTL2B Antibody Products:
Assay Products for METTL2B: |
Protein
Domains /
Families
for METTL2B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
METTL2B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6P1Q9ProtoNet protein and cluster: Q6P1Q9 UniProtKB/Swiss-Prot: MET2B_HUMAN, Q6P1Q9Similarity: Belongs to the methyltransferase superfamily. METL family |
Function
for METTL2B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MET2B_HUMAN, Q6P1Q9Function: Probable methyltransferase (By similarity)Enzyme Number (IUBMB): EC 2.1.1.-1
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL2B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL2B |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008168 | methyltransferase activity |
IEA | -- |
METTL2B for ontologies About GeneDecksing
|
Pathways & Interactions
for METTL2B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Tyrosine metabolism | | | 2 | Histidine metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Kegg Pathways (Kegg details for METTL2B):
METTL2B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for METTL2B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/11 Interacting proteins for METTL2B (Q6P1Q93 ENSP000002624324) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
|
Drugs & Compounds
for METTL2B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for METTL2B
Search CenterWatch for drugs/clinical trials and news about METTL2B / MET2B
|
Transcripts
for METTL2B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for METTL2B gene: NM_018396.2 Unigene Cluster for METTL2B: Methyltransferase like 2B Hs.433213 [show with all ESTs]Unigene Representative Sequence: NM_0183968 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000462662 ENST00000482555 ENST00000262432(uc003vnf.3 uc003vng.3 uc011kop.2)
ENST00000497665 ENST00000480046 ENST00000473488 ENST00000419443 ENST00000481392
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL2B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL2B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: METTL2B (NM_018396) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for METTL2B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL2B |
Additional cDNA sequence: AF086194.1 AK002212.1 AK299960.1 AK302775.1 AY358237.1 BC064929.1 BC121115.1 BC121116.1 15 DOTS entries: DT.100818209 DT.95225364 DT.95327348 DT.121120029 DT.92440296 DT.100818216 DT.430610 DT.86856005 DT.95225403 DT.120934872 DT.120934877 DT.40130383 DT.75181766 DT.92440304 DT.95225353 24/340 AceView cDNA sequences (see all 340): BU689113 BU156725 CA841985 BM763955 AI591134 CR598155 AA347128 AL538414 BG682088 CR617951 BQ011771 BC001863 CA841693 BM764811 CR613444 BX093239 BQ420817 BQ185473 BX094542 AL567296 BG110390 BF477370 BF338594 BQ436909
GeneLoc Exon Structure
|
Expression
for METTL2B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| METTL2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See METTL2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for METTL2B
SOURCE GeneReport for Unigene cluster: Hs.433213
SABiosciences Custom PCR Arrays for METTL2B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for METTL2B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat METTL2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL2B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL2B |
Orthologs
for METTL2B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for METTL2B gene from 7/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
METTL2A6 |
methyltransferase like 2B |
63(a) |
1 → many |
27(2238733-2251624) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
61(a) |
1 → many |
6(66014924-66024617) |
zebrafish
(Danio rerio) |
Actinopterygii |
mettl2a6 |
methyltransferase like 2A |
65(a) |
1 → many |
3(19552544-19570044) |
fruit fly
(Drosophila melanogaster) |
Insecta |
metl6 |
methyltransferase-like |
48(a) |
1 → many |
3L(1637942-1639235) |
worm
(Caenorhabditis elegans) |
Secernentea |
Y53F4B.426 |
-- |
47(a) |
1 → many |
II(14969826-14970843) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G546506 |
Methyltransferase family protein |
31(a) |
possible ortholog |
1(20405598-20407753) |
rice
(Oryza sativa) |
Liliopsida |
-- |
methyltransferase, putative, expressed |
30(a) |
possible ortholog |
7(13056799-13067292) |
ENSEMBL Gene Tree for METTL2B (if available)
TreeFam Gene Tree for METTL2B (if available) |
Paralogs
for METTL2B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for METTL2B gene
- METTL62 METTL2A2 METTL82
8 SIMAP similar genes for METTL2B using alignment to 5 protein entries: MET2B_HUMAN (see all proteins):METTL2A C8orf44 CIR1 C8orf17 METTL8 FLJ13984
LZLP METTL6
METTL2B for paralogs About GeneDecksing
|
Genomic Variants
for METTL2B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for METTL2B (128095894 - 128146656 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for METTL2B
1 CNV: 4558
1 Indel: 41025 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing METTL2B |
|
Disorders
/ Diseases
for METTL2B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
METTL2B for disorders About GeneDecksing
OMIM gene information: 607846
OMIM disorders: --
1  disease for METTL2B: About MalaCardsmalaria
Export disorders for METTL2B gene to outside databases
|
Publications
for METTL2B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for METTL2B gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with METTL2B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a novel family of putative methyltransferases that interact with human and Drosophila presenilins. (PubMed id 11738826)1, 3, 9 Zhang S.X....Boulianne G.L. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
|
External Searches for METTL2B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing METTL2B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing METTL2B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing METTL2B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for METTL2B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for METTL2B gene:
Search GeneIP for patents involving METTL2B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for METTL2B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat METTL2B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing METTL2B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL2B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat METTL2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL2B |
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 | | | METTL2B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL2B |
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