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Aliases for METTL2B Gene

Aliases for METTL2B Gene

  • Methyltransferase Like 2B 2 3 5
  • Methyltransferase Like 2 2
  • EC 2.1.1.- 4
  • METTL2A 3
  • PSENIP1 3
  • METTL2 3
  • METL 3

External Ids for METTL2B Gene

Previous HGNC Symbols for METTL2B Gene

  • METTL2

Previous GeneCards Identifiers for METTL2B Gene

  • GC07P127904
  • GC07P128098
  • GC07P128103
  • GC07P122477
  • GC07P128105
  • GC07P128108
  • GC07P128120
  • GC07P128510
  • GC07P128530

Summaries for METTL2B Gene

Entrez Gene Summary for METTL2B Gene

  • This gene is a member of a family of methyltransferases that share homology with, but are distinct from, the UbiE family of methyltransferases. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for METTL2B Gene

METTL2B (Methyltransferase Like 2B) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity and tRNA (cytosine) methyltransferase activity. An important paralog of this gene is METTL2A.

UniProtKB/Swiss-Prot for METTL2B Gene

  • Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs.

Gene Wiki entry for METTL2B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL2B Gene

Genomics for METTL2B Gene

Regulatory Elements for METTL2B Gene

Genomic Location for METTL2B Gene

Chromosome:
7
Start:
128,476,729 bp from pter
End:
128,506,602 bp from pter
Size:
29,874 bases
Orientation:
Plus strand

Genomic View for METTL2B Gene

Genes around METTL2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL2B Gene

Proteins for METTL2B Gene

  • Protein details for METTL2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P1Q9-MET2B_HUMAN
    Recommended name:
    Methyltransferase-like protein 2B
    Protein Accession:
    Q6P1Q9
    Secondary Accessions:
    • B4DZ68
    • Q0IJ54
    • Q3B7J1

    Protein attributes for METTL2B Gene

    Size:
    378 amino acids
    Molecular mass:
    43426 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for METTL2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for METTL2B Gene

Proteomics data for METTL2B Gene at MOPED

Post-translational modifications for METTL2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for METTL2B Gene

Antibody Products

No data available for DME Specific Peptides for METTL2B Gene

Domains & Families for METTL2B Gene

Gene Families for METTL2B Gene

Protein Domains for METTL2B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for METTL2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P1Q9

UniProtKB/Swiss-Prot:

MET2B_HUMAN :
  • Belongs to the methyltransferase superfamily. METL family.
Family:
  • Belongs to the methyltransferase superfamily. METL family.
genes like me logo Genes that share domains with METTL2B: view

Function for METTL2B Gene

Molecular function for METTL2B Gene

UniProtKB/Swiss-Prot Function:
Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs.

Enzyme Numbers (IUBMB) for METTL2B Gene

genes like me logo Genes that share phenotypes with METTL2B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL2B Gene

Localization for METTL2B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for METTL2B Gene COMPARTMENTS Subcellular localization image for METTL2B gene
Compartment Confidence
cytosol 3
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for METTL2B Gene

Pathways & Interactions for METTL2B Gene

SuperPathways for METTL2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for METTL2B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for METTL2B Gene

Drugs & Compounds for METTL2B Gene

(7) Drugs for METTL2B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Histidine Approved Nutra 0
S-Adenosylmethionine Approved Nutra 0
Tetrahydrofolic acid Approved Nutra 0
3-hydroxyanthranilic acid Experimental Pharma 0
5-methyltetrahydrofolate Experimental Pharma 0

(15) Additional Compounds for METTL2B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1,6-Dimethoxypyrene
1-Hydroxy-6-methoxypyrene
1-Hydroxyphenanthrene
  • 1-phenanthrenol
  • phenanthren-1-ol
1-Hydroxypyrene
  • 1-Hydroxy pyrene
  • 1-HYDROXYPYRENE
  • 1-Pyrenol
  • Pyren-1-ol
5315-79-7
1-Methoxyphenanthrene
genes like me logo Genes that share compounds with METTL2B: view

Transcripts for METTL2B Gene

Unigene Clusters for METTL2B Gene

Methyltransferase like 2B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL2B Gene

No ASD Table

Relevant External Links for METTL2B Gene

GeneLoc Exon Structure for
METTL2B
ECgene alternative splicing isoforms for
METTL2B

Expression for METTL2B Gene

mRNA expression in normal human tissues for METTL2B Gene

Protein differential expression in normal tissues from HIPED for METTL2B Gene

This gene is overexpressed in Adrenal (55.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for METTL2B Gene



SOURCE GeneReport for Unigene cluster for METTL2B Gene Hs.433213

genes like me logo Genes that share expression patterns with METTL2B: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for METTL2B Gene

Orthologs for METTL2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for METTL2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL2B 36
  • 99 (a)
OneToOne
METTL2B 35
  • 99.21 (n)
  • 98.68 (a)
cow
(Bos Taurus)
Mammalia METTL2 36
  • 84 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 64 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mettl2 36
  • 76 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 73 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
OneToMany
chicken
(Gallus gallus)
Aves METTL2 36
  • 65 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 60 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii mettl2a 36
  • 66 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta metl 36
  • 48 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y53F4B.42 36
  • 48 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ABP140 36
  • 21 (a)
OneToMany
Species with no ortholog for METTL2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for METTL2B Gene

ENSEMBL:
Gene Tree for METTL2B (if available)
TreeFam:
Gene Tree for METTL2B (if available)

Paralogs for METTL2B Gene

Paralogs for METTL2B Gene

(8) SIMAP similar genes for METTL2B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with METTL2B: view

Variants for METTL2B Gene

Sequence variations from dbSNP and Humsavar for METTL2B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs2896399 - 128,479,325(+) AAGTA(C/T)GTGAA reference, missense
rs2023329 - 128,479,340(-) CTCAT(G/T)GTTTC reference, missense
rs1065267 - 128,479,460(+) ACCTG(A/G)AAATT reference, missense
rs2562741 - 128,493,930(+) CAGCA(A/G)TTGTT reference, missense
rs2288557 - 128,477,173(+) AACAA(A/C/G)GTGCG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for METTL2B Gene

Variant ID Type Subtype PubMed ID
nsv831124 CNV Gain+Loss 17160897
esv2735137 CNV Deletion 23290073
esv2670312 CNV Deletion 23128226

Variation tolerance for METTL2B Gene

Residual Variation Intolerance Score: 88.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.19; 80.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for METTL2B Gene

HapMap Linkage Disequilibrium report
METTL2B
Human Gene Mutation Database (HGMD)
METTL2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL2B Gene

Disorders for METTL2B Gene

Relevant External Links for METTL2B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
METTL2B

No disorders were found for METTL2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL2B Gene

Publications for METTL2B Gene

  1. Identification of a novel family of putative methyltransferases that interact with human and Drosophila presenilins. (PMID: 11738826) Zhang S.X. … Boulianne G.L. (Gene 2001) 2 3 23 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  4. Actin-binding protein ABP140 is a methyltransferase for 3- methylcytidine at position 32 of tRNAs in Saccharomyces cerevisiae. (PMID: 21518805) Noma A. … Suzuki T. (RNA 2011) 3
  5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 3

Products for METTL2B Gene

Sources for METTL2B Gene

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