Free for academic non-profit institutions. Other users need a Commercial license

Aliases for METTL2B Gene

Aliases for METTL2B Gene

  • Methyltransferase Like 2B 2 3
  • Methyltransferase-Like Protein 2B 3
  • Methyltransferase Like 2 2
  • EC 2.1.1.- 4
  • METTL2A 3
  • PSENIP1 3
  • METTL2 3
  • METL 3

External Ids for METTL2B Gene

Previous HGNC Symbols for METTL2B Gene

  • METTL2

Previous GeneCards Identifiers for METTL2B Gene

  • GC07P127904
  • GC07P128098
  • GC07P128103
  • GC07P122477
  • GC07P128105
  • GC07P128108
  • GC07P128120

Summaries for METTL2B Gene

Entrez Gene Summary for METTL2B Gene

  • This gene is a member of a family of methyltransferases that share homology with, but are distinct from, the UbiE family of methyltransferases. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for METTL2B Gene

METTL2B (Methyltransferase Like 2B) is a Protein Coding gene. Among its related pathways are Phenylalanine metabolism and Histidine metabolism. GO annotations related to this gene include tRNA (cytosine) methyltransferase activity. An important paralog of this gene is METTL8.

UniProtKB/Swiss-Prot for METTL2B Gene

  • Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs.

Gene Wiki entry for METTL2B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL2B Gene

Genomics for METTL2B Gene

Regulatory Elements for METTL2B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for METTL2B Gene

128,476,729 bp from pter
128,506,602 bp from pter
29,874 bases
Plus strand

Genomic View for METTL2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for METTL2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL2B Gene

Proteins for METTL2B Gene

  • Protein details for METTL2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Methyltransferase-like protein 2B
    Protein Accession:
    Secondary Accessions:
    • B4DZ68
    • Q0IJ54
    • Q3B7J1

    Protein attributes for METTL2B Gene

    378 amino acids
    Molecular mass:
    43426 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for METTL2B Gene


neXtProt entry for METTL2B Gene

Proteomics data for METTL2B Gene at MOPED

Post-translational modifications for METTL2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for METTL2B Gene

Antibody Products

No data available for DME Specific Peptides for METTL2B Gene

Domains for METTL2B Gene

Protein Domains for METTL2B Gene


Suggested Antigen Peptide Sequences for METTL2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q6P1Q9
  • Belongs to the methyltransferase superfamily. METL family.
genes like me logo Genes that share domains with METTL2B: view

No data available for Gene Families for METTL2B Gene

Function for METTL2B Gene

Molecular function for METTL2B Gene

UniProtKB/Swiss-Prot Function:
Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs.

Enzyme Numbers (IUBMB) for METTL2B Gene

Gene Ontology (GO) - Molecular Function for METTL2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity --
GO:0016427 tRNA (cytosine) methyltransferase activity IMP 21518805
genes like me logo Genes that share ontologies with METTL2B: view

Animal Model Products

CRISPR Products

miRNA for METTL2B Gene

miRTarBase miRNAs that target METTL2B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for METTL2B

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for METTL2B Gene

Localization for METTL2B Gene

Subcellular locations from

Jensen Localization Image for METTL2B Gene COMPARTMENTS Subcellular localization image for METTL2B gene
Compartment Confidence
cytosol 3
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for METTL2B Gene

Pathways for METTL2B Gene

genes like me logo Genes that share pathways with METTL2B: view

Pathways by source for METTL2B Gene

2 KEGG pathways for METTL2B Gene

Gene Ontology (GO) - Biological Process for METTL2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0030488 tRNA methylation IMP 21518805
genes like me logo Genes that share ontologies with METTL2B: view

Transcripts for METTL2B Gene

Unigene Clusters for METTL2B Gene

Methyltransferase like 2B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for METTL2B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL2B Gene

No ASD Table

Relevant External Links for METTL2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL2B Gene

mRNA expression in normal human tissues for METTL2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for METTL2B Gene

This gene is overexpressed in Adrenal (55.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for METTL2B Gene

SOURCE GeneReport for Unigene cluster for METTL2B Gene Hs.433213

genes like me logo Genes that share expressions with METTL2B: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for METTL2B Gene

Orthologs for METTL2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for METTL2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia METTL2B 35
  • 99.21 (n)
  • 98.68 (a)
  • 99 (a)
(Mus musculus)
Mammalia Mettl2 16
Mettl2 36
  • 76 (a)
(Bos Taurus)
Mammalia METTL2 36
  • 84 (a)
(Canis familiaris)
Mammalia -- 36
  • 64 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
(Gallus gallus)
Aves METTL2 36
  • 65 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 60 (a)
(Danio rerio)
Actinopterygii mettl2a 36
  • 66 (a)
fruit fly
(Drosophila melanogaster)
Insecta metl 36
  • 48 (a)
(Caenorhabditis elegans)
Secernentea Y53F4B.42 36
  • 48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ABP140 36
  • 21 (a)
Species with no ortholog for METTL2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for METTL2B Gene

Gene Tree for METTL2B (if available)
Gene Tree for METTL2B (if available)

Paralogs for METTL2B Gene

Paralogs for METTL2B Gene

Selected SIMAP similar genes for METTL2B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with METTL2B: view

Variants for METTL2B Gene

Sequence variations from dbSNP and Humsavar for METTL2B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs891212 -- 128,480,067(+) CTGGT(C/T)AGCCT intron-variant
rs1053124 -- 128,501,811(+) CAGAA(C/T)CTGGT synonymous-codon, reference
rs1053141 -- 128,502,105(+) Gtaat(A/G)ataaa utr-variant-3-prime
rs1061927 -- 128,502,420(+) TGAGA(A/G)TGTAA utr-variant-3-prime
rs1061928 -- 128,502,461(+) TACAG(A/G)GGTTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for METTL2B Gene

Variant ID Type Subtype PubMed ID
nsv831124 CNV Gain+Loss 17160897
esv2735137 CNV Deletion 23290073
esv2670312 CNV Deletion 23128226

Relevant External Links for METTL2B Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL2B Gene

Disorders for METTL2B Gene

No disorders were found for METTL2B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for METTL2B Gene

Publications for METTL2B Gene

  1. Identification of a novel family of putative methyltransferases that interact with human and Drosophila presenilins. (PMID: 11738826) Zhang S.X. … Boulianne G.L. (Gene 2001) 2 3 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Actin-binding protein ABP140 is a methyltransferase for 3- methylcytidine at position 32 of tRNAs in Saccharomyces cerevisiae. (PMID: 21518805) Noma A. … Suzuki T. (RNA 2011) 3 4
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for METTL2B Gene

Sources for METTL2B Gene

Back to Top