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METTL2B Gene

protein-coding   GIFtS: 50
GCID: GC07P128120

Methyltransferase Like 2B

(Previous name: methyltransferase like 2)
(Previous symbol: METTL2)
  Search for METTL2B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Methyltransferase Like 2B1 2     METTL2A2
METTL21 2     PSENIP12
Methyltransferase Like 21     Methyltransferase-Like Protein 2B2
METL2     EC 2.1.1.-3

External Ids:    HGNC: 182721   Entrez Gene: 557982   Ensembl: ENSG000001650557   OMIM: 6078465   UniProtKB: Q6P1Q93   

Export aliases for METTL2B gene to outside databases

Previous GC identifers: GC07P127904 GC07P128098 GC07P128103 GC07P122477 GC07P128105 GC07P128108


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for METTL2B Gene:
This gene is a member of a family of methyltransferases that share homology with, but are distinct from, the UbiE
family of methyltransferases. Alternatively spliced variants which encode different protein isoforms have been
described; however, not all variants have been fully characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for METTL2B Gene:
METTL2B (methyltransferase like 2B) is a protein-coding gene. GO annotations related to this gene include tRNA (cytosine) methyltransferase activity. An important paralog of this gene is METTL6.

UniProtKB/Swiss-Prot: MET2B_HUMAN, Q6P1Q9
Function: Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification
of some tRNAs

Gene Wiki entry for METTL2B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the METTL2B gene promoter:
         NF-AT4   NF-AT2   AML1a   FOXO4   NF-AT3   LyF-1   NF-AT1   NF-AT   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMETTL2B promoter sequence
   Search Chromatin IP Primers for METTL2B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat METTL2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32.1   Ensembl cytogenetic band:  7q32.1   HGNC cytogenetic band: 7q32.2

METTL2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
METTL2B gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P128120:  view genomic region     (about GC identifiers)

Start:
128,116,783 bp from pter      End:
128,146,656 bp from pter
Size:
29,874 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 127,499,894-127,526,089     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MET2B_HUMAN, Q6P1Q9 (See protein sequence)
Recommended Name: Methyltransferase-like protein 2B  
Size: 378 amino acids; 43426 Da
Secondary accessions: B4DZ68 Q0IJ54 Q3B7J1
Alternative splicing: 2 isoforms:  Q6P1Q9-1   Q6P1Q9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for METTL2B: NX_Q6P1Q9

Explore proteomics data for METTL2B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See METTL2B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060866.2  
    ENSEMBL proteins: 
     ENSP00000262432   ENSP00000417616   ENSP00000418402   ENSP00000405144   ENSP00000418989  

    METTL2B Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for METTL2B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026113 MeTrfase

    Graphical View of Domain Structure for InterPro Entry Q6P1Q9

    ProtoNet protein and cluster: Q6P1Q9

    UniProtKB/Swiss-Prot: MET2B_HUMAN, Q6P1Q9
    Similarity: Belongs to the methyltransferase superfamily. METL family


    METTL2B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MET2B_HUMAN, Q6P1Q9
    Function: Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification
    of some tRNAs

         Enzyme Number (IUBMB): EC 2.1.1.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008168methyltransferase activity ----
    GO:0016427tRNA (cytosine) methyltransferase activity IMP--
         
    METTL2B for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for METTL2B
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    miRTarBase miRNAs that target METTL2B:
    hsa-mir-92a-3p (MIRT049548), hsa-mir-484 (MIRT041715), hsa-mir-375 (MIRT019741)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for METTL2B About    
    See pathways by source

    SuperPathContained pathways About
    1Phenylalanine metabolism
    Tyrosine metabolism0.36
    2Histidine metabolism
    Histidine metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    2 Kegg Pathways  (Kegg details for METTL2B):
        Histidine metabolism
    Tyrosine metabolism


    METTL2B for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for METTL2B
    Interactions:

        Search GeneGlobe Interaction Network for METTL2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for METTL2B (Q6P1Q93 ENSP000002624324) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSEN1P497683, ENSP000003263664I2D: score=1 STRING: ENSP00000326366
    PSEN2P498103, ENSP000003557474I2D: score=5 STRING: ENSP00000355747
    DYNLL2Q96FJ23I2D: score=4 
    DYNLT1P631723I2D: score=3 
    RALAP112333I2D: score=3 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process ----
    GO:0030488tRNA methylation IMP--

    METTL2B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for METTL2B (MET2B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for METTL2B gene: 
    NM_018396.2  

    Unigene Cluster for METTL2B:

    Methyltransferase like 2B
    Hs.433213  [show with all ESTs]
    Unigene Representative Sequence: NM_018396
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000482555 ENST00000262432(uc003vnf.3 uc003vng.3 uc011kop.2)
    ENST00000497665 ENST00000480046 ENST00000473488 ENST00000419443 ENST00000481392

    miRNA
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    Additional mRNA sequence: 

    AF086194.1 AK002212.1 AK299960.1 AK302775.1 AY358237.1 BC064929.1 BC121115.1 BC121116.1 

    15 DOTS entries:

    DT.100818209  DT.95225364  DT.95327348  DT.121120029  DT.92440296  DT.100818216  DT.430610  DT.86856005 
    DT.95225403  DT.120934872  DT.120934877  DT.40130383  DT.75181766  DT.92440304  DT.95225353 

    Selected AceView cDNA sequences (see all 340):

    CR623904 BU553682 BF338594 CD514136 CR624882 AL547979 BQ420817 AI591134 
    BQ187823 AW079667 BX281217 BM546738 BX093239 BQ012410 BI825349 AI343669 
    AI368420 AI308120 CA426397 BU689113 BM849757 CR613444 BF726610 CR617951 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    METTL2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    METTL2B Expression
    About this image


    METTL2B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Eye (Sensory Organs)
             Lens
     
     Neural Tube (Nervous System)
             Metencephalon
    METTL2B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    METTL2B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.433213
        Custom PCR Arrays for METTL2B
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for METTL2B gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mettl25 methyltransferase like 2   --   11 (68.61 cM) 105126425 
    chicken
    (Gallus gallus)
    Aves METTL26
    Gallus gallus methyltransferase like 2A (METTL2A),...
    65(a)
    1 → many
    27(2332100-2344617) ENSGALG00000000396
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    60(a)
    1 → many
    6(66014724-66028623)
    zebrafish
    (Danio rerio)
    Actinopterygii mettl2a6
    methyltransferase like 2A
    66(a)
    1 → many
    3(19552544-19570044) ENSDARG00000008105
    fruit fly
    (Drosophila melanogaster)
    Insecta metl6
    methyltransferase-like
    48(a)
    1 → many
    3L(1637942-1639235)
    worm
    (Caenorhabditis elegans)
    Secernentea Y53F4B.426
    Protein Y53F4B.42 (Y53F4B.42) mRNA, complete cds
    48(a)
    1 → many
    II(14969902-14971652) WBGene00044720
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ABP1406
    AdoMet-dependent tRNA methyltransferase and actin ...
    21(a)
    1 → many
    XV(784857-786744) YOR239W


    ENSEMBL Gene Tree for METTL2B (if available)
    TreeFam Gene Tree for METTL2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for METTL2B gene
    METTL62  METTL2A2  METTL82  
    8 SIMAP similar genes for METTL2B using alignment to 4 protein entries:     MET2B_HUMAN (see all proteins):
    METTL2A    C8orf44    CIR1    C8orf17    METTL8    FLJ13984
    LZLP    METTL6

    METTL2B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for METTL2B (see all 614)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1511603951,2
    C--128114901(+) GATCAC/TGCCAC 1 -- us2k10--------
    rs1810970631,2
    --128114931(+) CAGTGC/GGAGAC 1 -- us2k10--------
    rs117679931,2
    C,F,H--128114939(+) GACTCT/CGTCTC 1 -- us2k14Minor allele frequency- C:0.43NA CSA 7
    rs1483824091,2
    C--128114946(+) CTCAA-/AAAT/ 
    AAATAAAT
    AAATA
    1 -- us2k10--------
    rs1860215631,2
    C--128115178(+) CACAGA/GTGAGA 1 -- us2k10--------
    rs1437523681,2
    C--128115377(+) ATTAAC/TTTGTG 1 -- us2k10--------
    rs1468502491,2
    C--128115424(+) TCCCAC/TTTCTT 1 -- us2k10--------
    rs1500606171,2
    C--128115660(+) GGTAGC/TGCGCA 1 -- us2k10--------
    rs1454211871,2
    C--128115661(+) GTAGCA/GCGCAC 1 -- us2k10--------
    rs1909280031,2
    --128115693(+) AGGCTA/GAGGCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for METTL2B (128116783 - 128146656 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for METTL2B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2735137CNV Deletion23290073
    esv2670312CNV Deletion23128226
    nsv831124CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607846    OMIM disorders: --


    METTL2B for disorders           About GeneDecksing


    Export disorders for METTL2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for METTL2B gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with METTL2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel family of putative methyltransferases that interact with human and Drosophila presenilins. (PubMed id 11738826)1, 3, 9 Zhang S.X....Boulianne G.L. (Gene 2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    6. Actin-binding protein ABP140 is a methyltransferase for 3- methylcytidine at position 32 of tRNAs in Saccharomyces cerevisiae. (PubMed id 21518805)2 Noma A.... Suzuki T. (RNA 2011)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55798 HGNC: 18272 AceView: HIG2andMETTL2andLOC441279 Ensembl:ENSG00000165055 euGenes: HUgn55798
    ECgene: METTL2B Kegg: 55798 H-InvDB: METTL2B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for METTL2B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for METTL2B gene:
    Search GeneIP for patents involving METTL2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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