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METTL2A Gene

protein-coding   GIFtS: 45
GCID: GC17P060501

Methyltransferase Like 2A

  Search for METTL2A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Methyltransferase Like 2A1 2
METTL22 3
Methyltransferase-Like Protein 2A2
EC 2.1.1.-3

External Ids:    HGNC: 257551   Entrez Gene: 3391752   Ensembl: ENSG000000879957   UniProtKB: Q96IZ63   

Export aliases for METTL2A gene to outside databases

Previous GC identifers: GC17P057855 GC17P055867


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for METTL2A Gene:
METTL2A (methyltransferase like 2A) is a protein-coding gene. GO annotations related to this gene include tRNA (cytosine) methyltransferase activity. An important paralog of this gene is METTL2B.

UniProtKB/Swiss-Prot: MET2A_HUMAN, Q96IZ6
Function: Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification
of some tRNAs (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the METTL2A gene promoter:
         TBP   RP58   AML1a   HSF1 (long)   E47   FOXO4   TFIID   HSF1short   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMETTL2A promoter sequence
   Search Chromatin IP Primers for METTL2A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat METTL2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.2   Ensembl cytogenetic band:  17q23.2   HGNC cytogenetic band: 17q23.3

METTL2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
METTL2A gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P060501:  view genomic region     (about GC identifiers)

Start:
60,501,228 bp from pter      End:
60,527,454 bp from pter
Size:
26,227 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MET2A_HUMAN, Q96IZ6 (See protein sequence)
Recommended Name: Methyltransferase-like protein 2A  
Size: 378 amino acids; 43537 Da
Sequence caution: Sequence=BAB14260.1; Type=Erroneous initiation;
Secondary accessions: A6NNC4 Q9H9G9 Q9NUI8 Q9P0B5
Alternative splicing: 2 isoforms:  Q96IZ6-1   Q96IZ6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for METTL2A: NX_Q96IZ6

Explore proteomics data for METTL2A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See METTL2A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_859076.3  
    ENSEMBL proteins: 
     ENSP00000309610  

    METTL2A Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for METTL2A

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026113 MeTrfase

    Graphical View of Domain Structure for InterPro Entry Q96IZ6

    ProtoNet protein and cluster: Q96IZ6

    UniProtKB/Swiss-Prot: MET2A_HUMAN, Q96IZ6
    Similarity: Belongs to the methyltransferase superfamily. METL family


    Find genes that share domains with METTL2A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MET2A_HUMAN, Q96IZ6
    Function: Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification
    of some tRNAs (By similarity)

         Enzyme Number (IUBMB): EC 2.1.1.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008168methyltransferase activity ----
    GO:0016427tRNA (cytosine) methyltransferase activity ISS--
         
    Find genes that share ontologies with METTL2A           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for METTL2A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for METTL2A

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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for METTL2A

    miRNA
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    miRTarBase miRNAs that target METTL2A:
    hsa-mir-375 (MIRT020020), hsa-mir-342-3p (MIRT043691), hsa-mir-454-3p (MIRT039224), hsa-mir-484 (MIRT041654), hsa-mir-92a-3p (MIRT049543)

    Block miRNA regulation of human, mouse, rat METTL2A using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate METTL2A:
    hsa-miR-513b
    SwitchGear 3'UTR luciferase reporter plasmidMETTL2A 3' UTR sequence
    Inhib. RNA
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    Sino Biological Human cDNA Clone for METTL2A
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL2A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    mitochondrion1
    nucleus1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for METTL2A
    Interactions:

        Search GeneGlobe Interaction Network for METTL2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for METTL2A (Q96IZ62, 3 ENSP000003096104) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK6Q166592, 3MINT-8261450 I2D: score=2 
    TRIP12ENSP000002839434STRING: ENSP00000283943
    HECTD1ENSP000003822694STRING: ENSP00000382269
    HSPD1ENSP000003400194STRING: ENSP00000340019
    TRMT1ENSP000003503524STRING: ENSP00000350352
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process ----
    GO:0030488tRNA methylation ISS--

    Find genes that share ontologies with METTL2A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for METTL2A (MET2A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for METTL2A gene (2 alternative transcripts): 
    NM_001005372.1  NM_181725.3  

    Unigene Cluster for METTL2A:

    Methyltransferase like 2A
    Hs.381204  [show with all ESTs]
    Unigene Representative Sequence: NM_181725
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311506(uc002izv.2 uc002izw.3) ENST00000333483 ENST00000582027

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat METTL2A using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate METTL2A:
    hsa-miR-513b
    SwitchGear 3'UTR luciferase reporter plasmidMETTL2A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for METTL2A
    Predesigned siRNA for gene silencing in human, mouse, rat METTL2A
    Clone
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    OriGene clones in human, mouse for METTL2A (see all 10)
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    GenScript: all cDNA clones in your preferred vector: METTL2A (NM_181725)
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat METTL2A
      QuantiTect SYBR Green Assays in human, mouse, rat METTL2A
      QuantiFast Probe-based Assays in human, mouse, rat METTL2A

    Additional mRNA sequence: 

    AF161384.1 AF161385.1 AK000991.1 AK022822.1 BC006985.1 

    14 DOTS entries:

    DT.95225403  DT.95225363  DT.100030093  DT.95225366  DT.120934902  DT.120934877  DT.92440304  DT.100818209 
    DT.65288274  DT.95225364  DT.120934872  DT.92440296  DT.95225353  DT.95338521 

    Selected AceView cDNA sequences (see all 139):

    BQ000496 BG403117 BE856364 CR595349 AI621120 BE792117 BU182023 AA632217 
    CA441076 N35537 BG574337 AI632244 BM756383 AA339213 BV204792 AW139836 
    BG289534 BI335415 BQ931354 BM971010 BF795187 BQ066662 BV204793 BU856779 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for METTL2A    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
    SP1:                                          
    SP2:                                          


    ECgene alternative splicing isoforms for METTL2A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    METTL2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    METTL2A Expression
    About this image

    METTL2A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    METTL2A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.381204
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL2A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for METTL2A gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mettl21 methyltransferase like 2 83.06(n)
    81.35(a)
      52686  NM_172567.3  NP_766155.3 
    chicken
    (Gallus gallus)
    Aves METTL2A1 methyltransferase like 2A 70.31(n)
    69.19(a)
      419948  NM_001006329.1  NP_001006329.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    60(a)
    1 → many
    6(66014724-66028623)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.52702 Xenopus laevis transcribed sequence with weak similarity to protein refNP_060866.1 (H.sapiens) hypothetical protein FLJ11350 [Homo sapiens] less 73.44(n)    BU908164.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.254612 Transcribed sequence with weak similarity to protein refNP_060866.1 (H.sapiens) hypothetical protein FLJ11350 [Homo sapiens] less 74.33(n)    CD759897.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta metl1 methyltransferase-like 57.45(n)
    56.36(a)
      38197  NM_139379.4  NP_647636.3 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_Y53F4B.421 CELE_Y53F4B.42 54.9(n)
    51.4(a)
      4363033  NM_001047362.2  NP_001040827.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ABP1406
    AdoMet-dependent tRNA methyltransferase and actin ...
    21(a)
    1 → many
    XV(784857-786744) YOR239W


    ENSEMBL Gene Tree for METTL2A (if available)
    TreeFam Gene Tree for METTL2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for METTL2A gene
    METTL2B2  METTL62  METTL82  
    3 SIMAP similar genes for METTL2A using alignment to 1 protein entry:     MET2A_HUMAN:
    METTL2B    FLJ13984    METTL8

    Find genes that share paralogs with METTL2A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for METTL2A (see all 625)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1434923851,2
    --60499293(+) CTACTC/TGGGAG 1 -- us2k10--------
    rs1480162321,2
    C--60499360(+) ATCACA/GCCACT 1 -- us2k10--------
    rs1419326671,2
    C--60499389(+) CAGTGC/TGAGAC 1 -- us2k10--------
    rs1472907471,2
    --60499393(+) GCGAGA/GCTCCG 1 -- us2k10--------
    rs1922292621,2
    --60499570(+) TGGGAC/TTGTTG 1 -- us2k10--------
    rs1409330711,2
    C--60499621(+) GCCCAC/TAGATG 1 -- us2k10--------
    rs1432699221,2
    C--60499629(+) ATGAGA/TAAACA 1 -- us2k10--------
    rs3740984181,2
    C--60499638(+) CAAGAC/TCCAGA 1 -- us2k10--------
    rs3754878811,2
    C--60499683(+) AGCTG-/CCTTGA 1 -- us2k10--------
    rs1475488961,2
    --60499685(+) CTGGCC/TTTGAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for METTL2A (60501228 - 60527454 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for METTL2A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908677CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing METTL2A
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for METTL2A gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with METTL2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)1, 2 Zody M.C.... Nusbaum C. (Nature 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    6. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    10. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 339175 HGNC: 25755 AceView: FLJ12760 Ensembl:ENSG00000087995 euGenes: HUgn339175
    ECgene: METTL2A H-InvDB: METTL2A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for METTL2A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for METTL2A gene:
    Search GeneIP for patents involving METTL2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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