METTL2A Gene
protein-coding GIFtS: 43
GCID: GC17P060501
|
|
methyltransferase like 2A
| |
Aliases
for METTL2A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Methyltransferase Like 2A1 2 | | METTL21 2 3 | | FLJ127601 | | Methyltransferase-Like Protein 2A2 | | EC 2.1.1.-3 |
Export aliases for METTL2A gene to outside databasesPrevious GC identifers: GC17P057855 GC17P055867 |
Summaries
for METTL2A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MET2A_HUMAN, Q96IZ6Function: Probable methyltransferase (By similarity)
|
Genomic Views
for METTL2A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the METTL2A gene promoter:
TBP RP58 AML1a HSF1 (long) E47 FOXO4 TFIID HSF1short RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for METTL2A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL2A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q23.2 Ensembl cytogenetic band: 17q23.2 HGNC cytogenetic band: 17q23.3METTL2A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P060501: view genomic region
(about GC identifiers)
Start:
|
60,501,228 bp from pter |
End:
|
60,527,454 bp from pter |
Size:
|
26,227 bases |
Orientation:
|
plus strand |
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Proteins
for METTL2A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MET2A_HUMAN, Q96IZ6 (See
protein sequence)Recommended Name: Methyltransferase-like protein 2A Size: 378 amino acids; 43537 Da
Sequence caution: Sequence=BAB14260.1; Type=Erroneous initiation;
Secondary accessions: A6NNC4 Q9H9G9 Q9NUI8 Q9P0B5Alternative splicing: 2 isoforms: Q96IZ6-1 Q96IZ6-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for METTL2A: NX_Q96IZ6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96IZ6
METTL2A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_859076.3
ENSEMBL proteins: ENSP00000309610
Human Recombinant Protein Products:
METTL2A Antibody Products:
Assay Products for METTL2A: |
Protein
Domains /
Families
for METTL2A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
METTL2A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96IZ6ProtoNet protein and cluster: Q96IZ6 UniProtKB/Swiss-Prot: MET2A_HUMAN, Q96IZ6Similarity: Belongs to the methyltransferase superfamily. METL family |
Function
for METTL2A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MET2A_HUMAN, Q96IZ6Function: Probable methyltransferase (By similarity)Enzyme Number (IUBMB): EC 2.1.1.-1
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL2A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: METTL2A (NM_181725) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for METTL2A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL2A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL2A |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008168 | methyltransferase activity |
IEA | -- |
METTL2A for ontologies About GeneDecksing
|
Pathways & Interactions
for METTL2A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for METTL2A
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for METTL2A (Q96IZ62, 3 ENSP000003096104) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for METTL2A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for METTL2A
Search CenterWatch for drugs/clinical trials and news about METTL2A / MET2A
|
Transcripts
for METTL2A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for METTL2A gene (2 alternative transcripts): NM_001005372.1 NM_181725.3 Unigene Cluster for METTL2A: Methyltransferase like 2A Hs.381204 [show with all ESTs]Unigene Representative Sequence: NM_1817253 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000311506(uc002izv.2 uc002izw.3) ENST00000333483 ENST00000582027
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL2A (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL2A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: METTL2A (NM_181725) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for METTL2A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL2A |
Additional cDNA sequence: AF161384.1 AF161385.1 AK000991.1 AK022822.1 BC006985.1 14 DOTS entries: DT.95225403 DT.95225363 DT.100030093 DT.95225366 DT.120934902 DT.120934877 DT.92440304 DT.100818209 DT.65288274 DT.95225364 DT.120934872 DT.92440296 DT.95225353 DT.95338521 24/139 AceView cDNA sequences (see all 139): AA632217 BQ000496 BG574337 N35537 BU182023 BM756383 BG403117 AA339213 BE856364 AI632244 CA441076 BE792117 AI621120 CR595349 F04616 AI970604 AU118175 BG476559 BU633327 BF027000 AI566084 BM837921 AW139836 CA440410
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for METTL2A About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b |
|---|
|
| SP1: | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for METTL2A
|
Expression
for METTL2A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| METTL2A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See METTL2A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for METTL2A
SOURCE GeneReport for Unigene cluster: Hs.381204
SABiosciences Custom PCR Arrays for METTL2A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for METTL2A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat METTL2A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL2A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL2A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL2A |
Orthologs
for METTL2A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for METTL2A gene from 9/33 species (see all 33) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
METTL2A1 |
methyltransferase like 2A |
70.22(n)
69.1(a) |
|
419948 NM_001006329.1 NP_001006329.1 |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
61(a) |
1 → many |
6(66014924-66024617) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.52702 |
Xenopus laevis transcribed sequence with weak similarity to protein refNP_060866.1 (H.sapiens) hypothetical protein FLJ11350 [Homo sapiens] less |
73.44(n) |
|
BU908164.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.254612 |
Transcribed sequence with weak similarity to protein refNP_060866.1 (H.sapiens) hypothetical protein FLJ11350 [Homo sapiens] less |
74.33(n) |
|
CD759897.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
metl1 |
methyltransferase-like |
58.16(n)
56.29(a) |
|
38197 NM_167907.2 NP_728647.2 |
worm
(Caenorhabditis elegans) |
Secernentea |
CELE_Y53F4B.421 |
Protein Y53F4B.42 |
54.83(n)
51.03(a) |
|
4363033 NM_001047362.1 NP_001040827.1 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
ABP1401 |
Abp140p |
51.48(n)
45.91(a) |
|
854414 NP_014882.4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G546506 |
Methyltransferase family protein |
30(a) |
possible ortholog |
1(20405598-20407753) |
rice
(Oryza sativa) |
Liliopsida |
-- |
methyltransferase, putative, expressed |
30(a) |
possible ortholog |
7(13056799-13067292) |
ENSEMBL Gene Tree for METTL2A (if available)
TreeFam Gene Tree for METTL2A (if available) |
Paralogs
for METTL2A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for METTL2A gene
- METTL62 METTL2B2 METTL82
3 SIMAP similar genes for METTL2A using alignment to 1 protein entry: MET2A_HUMAN:METTL2B FLJ13984 METTL8
METTL2A for paralogs About GeneDecksing
|
Genomic Variants
for METTL2A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for METTL2A (60501228 - 60527454 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for METTL2A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing METTL2A |
|
Disorders
/ Diseases
for METTL2A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
METTL2A for disorders About GeneDecksing
1  disease for METTL2A: About MalaCardsmalaria
Export disorders for METTL2A gene to outside databases
|
Publications
for METTL2A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for METTL2A gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with METTL2A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)1, 2 Zody M.C.... Nusbaum C. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
|
External Searches for METTL2A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing METTL2A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing METTL2A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing METTL2A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for METTL2A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for METTL2A gene:
Search GeneIP for patents involving METTL2A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for METTL2A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for METTL2A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for METTL2A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for METTL2A | | | OriGene Protein Over-expression Lysate for METTL2A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for METTL2A | | OriGene 3'-UTR Clone for METTL2A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL2A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL2A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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 | | | METTL2A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL2A |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL2A |
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