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Aliases for METTL2A Gene

Aliases for METTL2A Gene

  • Methyltransferase Like 2A 2 3 5
  • METTL2 3 4
  • Methyltransferase-Like Protein 2A 3
  • EC 2.1.1.- 4

External Ids for METTL2A Gene

Previous GeneCards Identifiers for METTL2A Gene

  • GC17P057855
  • GC17P060501
  • GC17P055867

Summaries for METTL2A Gene

GeneCards Summary for METTL2A Gene

METTL2A (Methyltransferase Like 2A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and tRNA (cytosine) methyltransferase activity. An important paralog of this gene is METTL2B.

UniProtKB/Swiss-Prot for METTL2A Gene

  • Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs.

Additional gene information for METTL2A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL2A Gene

Genomics for METTL2A Gene

GeneHancer (GH) Regulatory Elements for METTL2A Gene

Promoters and enhancers for METTL2A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I062423 Promoter/Enhancer 1.6 EPDnew ENCODE 550.8 +0.3 264 1.6 HDGF PKNOX1 ARNT ARID4B NEUROD1 SIN3A DMAP1 YY1 POLR2B E2F8 METTL2A MED13 PIR60058
GH17I062470 Enhancer 1.4 Ensembl ENCODE dbSUPER 18.5 +47.2 47234 1 PKNOX1 SMAD1 SIN3A FEZF1 ZNF207 FOS ZNF662 ZNF592 MEF2D ZNF610 INTS2 METTL2A MED13 NACA2 TLK2 RPS10P26
GH17I062789 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.1 +368.3 368290 5.9 PKNOX1 FOXA2 NEUROD1 SIN3A YBX1 FEZF1 ZBTB7B E2F8 ZNF207 FOS DDX42 MED13 INTS2 RPS10P26 MIR633 METTL2A TLK2 DCAF7 MARCH10 GC17M062789
GH17I062651 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.1 +229.6 229564 3.3 HDGF FOXA2 PKNOX1 NEUROD1 SIN3A FEZF1 ZBTB7B IRF4 YY1 E2F8 INTS2 MED13 RPS10P26 METTL2A ENSG00000207382 GC17M062662 GC17P062639 MRC2
GH17I062477 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 4.7 +55.3 55301 3.7 SIN3A ZBTB7B ZNF48 GLIS2 ELK1 SP3 NFYC MXD4 REST GLIS1 TLK2 MED13 RPS10P26 MRC2 METTL2A INTS2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around METTL2A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the METTL2A gene promoter:

Genomic Locations for METTL2A Gene

Genomic Locations for METTL2A Gene
26,956 bases
Plus strand

Genomic View for METTL2A Gene

Genes around METTL2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL2A Gene

Proteins for METTL2A Gene

  • Protein details for METTL2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Methyltransferase-like protein 2A
    Protein Accession:
    Secondary Accessions:
    • A6NNC4
    • Q9H9G9
    • Q9NUI8
    • Q9P0B5

    Protein attributes for METTL2A Gene

    378 amino acids
    Molecular mass:
    43537 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB14260.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for METTL2A Gene


neXtProt entry for METTL2A Gene

Post-translational modifications for METTL2A Gene

No Post-translational modifications

Other Protein References for METTL2A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for METTL2A Gene

Domains & Families for METTL2A Gene

Gene Families for METTL2A Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for METTL2A Gene

Suggested Antigen Peptide Sequences for METTL2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the methyltransferase superfamily. METL family.
  • Belongs to the methyltransferase superfamily. METL family.
genes like me logo Genes that share domains with METTL2A: view

Function for METTL2A Gene

Molecular function for METTL2A Gene

UniProtKB/Swiss-Prot Function:
Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs.

Enzyme Numbers (IUBMB) for METTL2A Gene

Gene Ontology (GO) - Molecular Function for METTL2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016427 tRNA (cytosine) methyltransferase activity ISS --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with METTL2A: view

Phenotypes for METTL2A Gene

genes like me logo Genes that share phenotypes with METTL2A: view

Animal Model Products

CRISPR Products

miRNA for METTL2A Gene

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL2A Gene

Localization for METTL2A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL2A gene
Compartment Confidence
cytosol 3
mitochondrion 1
peroxisome 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for METTL2A Gene

Pathways & Interactions for METTL2A Gene

SuperPathways for METTL2A Gene

No Data Available

Gene Ontology (GO) - Biological Process for METTL2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030488 tRNA methylation ISS --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL2A: view

No data available for Pathways by source and SIGNOR curated interactions for METTL2A Gene

Drugs & Compounds for METTL2A Gene

No Compound Related Data Available

Transcripts for METTL2A Gene

Unigene Clusters for METTL2A Gene

Methyltransferase like 2A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL2A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b

Relevant External Links for METTL2A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for METTL2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for METTL2A Gene

This gene is overexpressed in Fetal Liver (28.3), Fetal ovary (24.4), and Fetal heart (15.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for METTL2A Gene

Protein tissue co-expression partners for METTL2A Gene

NURSA nuclear receptor signaling pathways regulating expression of METTL2A Gene:


SOURCE GeneReport for Unigene cluster for METTL2A Gene:


Evidence on tissue expression from TISSUES for METTL2A Gene

  • Nervous system(4.4)
  • Blood(4)
genes like me logo Genes that share expression patterns with METTL2A: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL2A Gene

Orthologs for METTL2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for METTL2A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia METTL2A 33 34
  • 98.94 (n)
(Canis familiaris)
Mammalia METTL2A 33
  • 88.89 (n)
-- 34
  • 63 (a)
(Bos Taurus)
Mammalia METTL2B 33
  • 87.02 (n)
  • 84 (a)
(Rattus norvegicus)
Mammalia Mettl2b 33
  • 83.11 (n)
(Mus musculus)
Mammalia Mettl2 33 16 34
  • 83.06 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 66 (a)
(Gallus gallus)
Aves METTL2A 33
  • 70.31 (n)
  • 65 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl2b 33
  • 68.11 (n)
Str.3463 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.5270 33
(Danio rerio)
Actinopterygii mettl2a 33 34
  • 70.72 (n)
Dr.25461 33
fruit fly
(Drosophila melanogaster)
Insecta metl 33 34
  • 57.45 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005973 33
  • 56.37 (n)
(Caenorhabditis elegans)
Secernentea CELE_Y53F4B.42 33
  • 54.9 (n)
Y53F4B.42 34
  • 48 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F11385g 33
  • 50.96 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ABP140 34
  • 21 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC21C3.07c 33
  • 52.89 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04647 33
  • 51.27 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4466 33
Species where no ortholog for METTL2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL2A Gene

Gene Tree for METTL2A (if available)
Gene Tree for METTL2A (if available)

Paralogs for METTL2A Gene

Paralogs for METTL2A Gene

(3) SIMAP similar genes for METTL2A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with METTL2A: view

Variants for METTL2A Gene

Sequence variations from dbSNP and Humsavar for METTL2A Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000205750 -- 62,422,156(+) T/C upstream_transcript_variant
rs1000377396 -- 62,439,507(+) T/C intron_variant
rs1000431522 -- 62,427,286(+) C/T intron_variant
rs1000553319 -- 62,444,322(+) C/T intron_variant
rs1000605822 -- 62,444,710(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for METTL2A Gene

Variant ID Type Subtype PubMed ID
esv3640974 CNV gain 21293372
esv3640975 CNV loss 21293372
nsv962358 CNV duplication 23825009

Variation tolerance for METTL2A Gene

Residual Variation Intolerance Score: 71.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.14; 38.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for METTL2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL2A Gene

Disorders for METTL2A Gene

Additional Disease Information for METTL2A

No disorders were found for METTL2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL2A Gene

Publications for METTL2A Gene

  1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 3 4 58

Products for METTL2A Gene

Sources for METTL2A Gene

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