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Aliases for METTL2A Gene

Aliases for METTL2A Gene

  • Methyltransferase Like 2A 2 3 5
  • METTL2 3 4
  • Methyltransferase-Like Protein 2A 3
  • EC 2.1.1.- 4

External Ids for METTL2A Gene

Previous GeneCards Identifiers for METTL2A Gene

  • GC17P057855
  • GC17P060501
  • GC17P055867

Summaries for METTL2A Gene

GeneCards Summary for METTL2A Gene

METTL2A (Methyltransferase Like 2A) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity and tRNA (cytosine) methyltransferase activity. An important paralog of this gene is METTL2B.

UniProtKB/Swiss-Prot for METTL2A Gene

  • Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL2A Gene

Genomics for METTL2A Gene

Regulatory Elements for METTL2A Gene

Enhancers for METTL2A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G062477 1.3 ENCODE dbSUPER 4.7 +55.3 55302 3.7 SIN3A ZNF48 ZBTB7B YY1 GLIS2 ELK1 CBX5 SP3 CEBPZ MXD4 MED13 MRC2 METTL2A INTS2 TLK2 RPS10P26
GH17G062616 1.2 Ensembl ENCODE 4.3 +194.8 194753 3.4 FOXA2 MLX ARID4B NFXL1 DMAP1 ZBTB7B RARA GATA2 SCRT2 ETV6 MRC2 METTL2A ENSG00000277463 GC17P062611
GH17G062489 0.5 dbSUPER 4.8 +67.0 66986 2.3 ZNF316 MAFG NR2F6 NFXL1 EMSY MRC2 METTL2A INTS2 RPS10P26 TLK2
GH17G062423 1.1 ENCODE 0.7 +0.3 264 1.6 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 METTL2A PIR60058
GH17G062421 0.8 Ensembl 0.7 -2.2 -2167 0.2 CTCF CREB3L1 NFIB SUZ12 ZIC2 ZNF2 ZBTB7B RAD21 CTBP1 SMC3 MRC2 METTL2A PIR38858
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around METTL2A on UCSC Golden Path with GeneCards custom track

Genomic Location for METTL2A Gene

62,423,867 bp from pter
62,450,822 bp from pter
26,956 bases
Plus strand

Genomic View for METTL2A Gene

Genes around METTL2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL2A Gene

Proteins for METTL2A Gene

  • Protein details for METTL2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Methyltransferase-like protein 2A
    Protein Accession:
    Secondary Accessions:
    • A6NNC4
    • Q9H9G9
    • Q9NUI8
    • Q9P0B5

    Protein attributes for METTL2A Gene

    378 amino acids
    Molecular mass:
    43537 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB14260.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for METTL2A Gene


neXtProt entry for METTL2A Gene

Post-translational modifications for METTL2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for METTL2A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for METTL2A Gene

Domains & Families for METTL2A Gene

Gene Families for METTL2A Gene

Protein Domains for METTL2A Gene

Suggested Antigen Peptide Sequences for METTL2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the methyltransferase superfamily. METL family.
  • Belongs to the methyltransferase superfamily. METL family.
genes like me logo Genes that share domains with METTL2A: view

Function for METTL2A Gene

Molecular function for METTL2A Gene

UniProtKB/Swiss-Prot Function:
Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs.

Enzyme Numbers (IUBMB) for METTL2A Gene

Gene Ontology (GO) - Molecular Function for METTL2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016427 tRNA (cytosine) methyltransferase activity ISS --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with METTL2A: view

Phenotypes for METTL2A Gene

genes like me logo Genes that share phenotypes with METTL2A: view

Animal Model Products

CRISPR Products

miRNA for METTL2A Gene

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL2A Gene

Localization for METTL2A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL2A gene
Compartment Confidence
cytosol 3
mitochondrion 1
peroxisome 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for METTL2A Gene

Pathways & Interactions for METTL2A Gene

SuperPathways for METTL2A Gene

No Data Available

Gene Ontology (GO) - Biological Process for METTL2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030488 tRNA methylation ISS --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL2A: view

No data available for Pathways by source and SIGNOR curated interactions for METTL2A Gene

Drugs & Compounds for METTL2A Gene

No Compound Related Data Available

Transcripts for METTL2A Gene

Unigene Clusters for METTL2A Gene

Methyltransferase like 2A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL2A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b

Relevant External Links for METTL2A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for METTL2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for METTL2A Gene

This gene is overexpressed in Fetal Liver (28.3), Fetal ovary (24.4), and Fetal heart (15.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for METTL2A Gene

Protein tissue co-expression partners for METTL2A Gene

NURSA nuclear receptor signaling pathways regulating expression of METTL2A Gene:


SOURCE GeneReport for Unigene cluster for METTL2A Gene:


Evidence on tissue expression from TISSUES for METTL2A Gene

  • Nervous system(4.4)
  • Blood(4)
genes like me logo Genes that share expression patterns with METTL2A: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL2A Gene

Orthologs for METTL2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for METTL2A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia METTL2A 34 35
  • 98.94 (n)
(Canis familiaris)
Mammalia METTL2A 34
  • 88.89 (n)
-- 35
  • 63 (a)
(Bos Taurus)
Mammalia METTL2B 34
  • 87.02 (n)
  • 84 (a)
(Rattus norvegicus)
Mammalia Mettl2b 34
  • 83.11 (n)
(Mus musculus)
Mammalia Mettl2 34 16 35
  • 83.06 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 66 (a)
(Gallus gallus)
Aves METTL2A 34
  • 70.31 (n)
  • 65 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl2b 34
  • 68.11 (n)
Str.3463 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.5270 34
(Danio rerio)
Actinopterygii mettl2a 34 35
  • 70.72 (n)
Dr.25461 34
fruit fly
(Drosophila melanogaster)
Insecta metl 34 35
  • 57.45 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005973 34
  • 56.37 (n)
(Caenorhabditis elegans)
Secernentea CELE_Y53F4B.42 34
  • 54.9 (n)
Y53F4B.42 35
  • 48 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F11385g 34
  • 50.96 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ABP140 35
  • 21 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC21C3.07c 34
  • 52.89 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04647 34
  • 51.27 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4466 34
Species where no ortholog for METTL2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL2A Gene

Gene Tree for METTL2A (if available)
Gene Tree for METTL2A (if available)

Paralogs for METTL2A Gene

Paralogs for METTL2A Gene

(3) SIMAP similar genes for METTL2A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with METTL2A: view

Variants for METTL2A Gene

Sequence variations from dbSNP and Humsavar for METTL2A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000205750 -- 62,422,156(+) TAATA(C/T)AGTAA upstream-variant-2KB
rs1000377396 -- 62,439,507(+) CAGCT(C/T)ACTGA intron-variant
rs1000431522 -- 62,427,286(+) CTCTG(C/T)ACTTT intron-variant
rs1000553319 -- 62,444,322(+) CGGCC(C/T)AGGCC intron-variant
rs1000605822 -- 62,444,710(+) GTAGA(A/G)GAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for METTL2A Gene

Variant ID Type Subtype PubMed ID
esv3640974 CNV gain 21293372
esv3640975 CNV loss 21293372
nsv962358 CNV duplication 23825009

Variation tolerance for METTL2A Gene

Residual Variation Intolerance Score: 71.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.14; 38.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for METTL2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL2A Gene

Disorders for METTL2A Gene

Relevant External Links for METTL2A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for METTL2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL2A Gene

Publications for METTL2A Gene

  1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4 64

Products for METTL2A Gene

Sources for METTL2A Gene

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