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METTL2A Gene

protein-coding GIFtS: 45
GCID: GC17P060501

Methyltransferase Like 2A

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disease database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Methyltransferase Like 2A¹ ²
METTL2² ³
Methyltransferase-Like Protein 2A²
EC 2.1.1.-³

External Ids:	HGNC: 25755¹	Entrez Gene: 339175²	Ensembl: ENSG00000087995⁷	UniProtKB: Q96IZ6³

Export aliases for METTL2A gene to outside databases

Previous GC identifers: GC17P057855 GC17P055867

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for METTL2A Gene:

METTL2A (methyltransferase like 2A) is a protein-coding gene. GO annotations related to this gene include tRNA (cytosine) methyltransferase activity. An important paralog of this gene is METTL2B.

UniProtKB/Swiss-Prot: MET2A_HUMAN, Q96IZ6

Function: Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification

of some tRNAs (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000017.10 NC_018928.2 NT_010783.16

Regulatory elements:

Regulatory transcription factor binding sites in the METTL2A gene promoter:
TBP RP58 AML1a HSF1 (long) E47 FOXO4 TFIID HSF1short RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: METTL2A promoter sequence

Search Chromatin IP Primers for METTL2A

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat METTL2A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.2 Ensembl cytogenetic band: 17q23.2 HGNC cytogenetic band: 17q23.3

METTL2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
METTL2A gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P060501: view genomic region (about GC identifiers)

Start:	60,501,228 bp from pter	End:	60,527,454 bp from pter
Size:	26,227 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MET2A_HUMAN, Q96IZ6 (See protein sequence)

Recommended Name: Methyltransferase-like protein 2A

Size: 378 amino acids; 43537 Da

Sequence caution: Sequence=BAB14260.1; Type=Erroneous initiation;

Secondary accessions: A6NNC4 Q9H9G9 Q9NUI8 Q9P0B5

Alternative splicing: 2 isoforms: Q96IZ6-1 Q96IZ6-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for METTL2A: NX_Q96IZ6

Explore proteomics data for METTL2A at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See METTL2A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_859076.3

ENSEMBL proteins:

ENSP00000309610

METTL2A Human Recombinant Protein Products:

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	antibodies-online proteins for METTL2A (2 products)
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	antibodies-online antibodies for METTL2A (7 products)

METTL2A Assay Products:

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	antibodies-online kits for METTL2A (2 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:

IPR026113 MeTrfase

Graphical View of Domain Structure for InterPro Entry Q96IZ6

ProtoNet protein and cluster: Q96IZ6

UniProtKB/Swiss-Prot: MET2A_HUMAN, Q96IZ6

Similarity: Belongs to the methyltransferase superfamily. METL family

Find genes that share domains with METTL2A About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: MET2A_HUMAN, Q96IZ6

Function: Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification

of some tRNAs (By similarity)

Enzyme Number (IUBMB): EC 2.1.1.-¹

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008168	methyltransferase activity	--	--
GO:0016427	tRNA (cytosine) methyltransferase activity	ISS	--

Find genes that share ontologies with METTL2A About GenesLikeMe

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for METTL2A

miRNA Products:		miRTarBase miRNAs that target METTL2A: hsa-mir-375 (MIRT020020), hsa-mir-342-3p (MIRT043691), hsa-mir-454-3p (MIRT039224), hsa-mir-484 (MIRT041654), hsa-mir-92a-3p (MIRT049543)

		Block miRNA regulation of human, mouse, rat METTL2A using miScript Target Protectors
		1 qRT-PCR Assays for microRNA that regulate METTL2A:
		hsa-miR-513b
		SwitchGear 3'UTR luciferase reporter plasmid: METTL2A 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for METTL2A
		Predesigned siRNA for gene silencing in human, mouse, rat METTL2A

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for METTL2A

Clone Products:		OriGene clones in human, mouse for METTL2A (see all 10) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL2A

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	3
mitochondrion	1
nucleus	1
peroxisome	1

About this image

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for METTL2A
Interactions:

Search GeneGlobe Interaction Network for METTL2A

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

Selected Interacting proteins for METTL2A (Q96IZ6^{2, 3} ENSP00000309610⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 18)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAPK6	Q16659²^,³	MINT-8261450 I2D: score=2
TRIP12	ENSP00000283943⁴	STRING: ENSP00000283943
HECTD1	ENSP00000382269⁴	STRING: ENSP00000382269
HSPD1	ENSP00000340019⁴	STRING: ENSP00000340019
TRMT1	ENSP00000350352⁴	STRING: ENSP00000350352

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Gene Ontology (GO): 2 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008152	metabolic process	--	--
GO:0030488	tRNA methylation	ISS	--

Find genes that share ontologies with METTL2A About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for METTL2A (MET2A)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for METTL2A gene (2 alternative transcripts):

NM_001005372.1 NM_181725.3

Unigene Cluster for METTL2A:

Methyltransferase like 2A

Hs.381204 [show with all ESTs]

Unigene Representative Sequence: NM_181725

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000311506(uc002izv.2 uc002izw.3) ENST00000333483 ENST00000582027

miRNA Products:		Block miRNA regulation of human, mouse, rat METTL2A using miScript Target Protectors
		1 qRT-PCR Assays for microRNA that regulate METTL2A:
		hsa-miR-513b
		SwitchGear 3'UTR luciferase reporter plasmid: METTL2A 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for METTL2A
		Predesigned siRNA for gene silencing in human, mouse, rat METTL2A

Clone Products:		OriGene clones in human, mouse for METTL2A (see all 10) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: METTL2A (NM_181725)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for METTL2A
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Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for METTL2A
		Pre-validated RT² qPCR Primer Assay in human, mouse / rat METTL2A
		QuantiTect SYBR Green Assays in human, mouse, rat METTL2A
		QuantiFast Probe-based Assays in human, mouse, rat METTL2A

Additional mRNA sequence:

AF161384.1 AF161385.1 AK000991.1 AK022822.1 BC006985.1

14 DOTS entries:

DT.95225403 DT.95225363 DT.100030093 DT.95225366 DT.120934902 DT.120934877 DT.92440304 DT.100818209

DT.65288274 DT.95225364 DT.120934872 DT.92440296 DT.95225353 DT.95338521

Selected AceView cDNA sequences (see all 139):

BQ000496 BG403117 BE856364 CR595349 AI621120 BE792117 BU182023 AA632217

CA441076 N35537 BG574337 AI632244 BM756383 AA339213 BV204792 AW139836

BG289534 BI335415 BQ931354 BM971010 BF795187 BQ066662 BV204793 BU856779

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for METTL2A About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b
SP1:
SP2:

ECgene alternative splicing isoforms for METTL2A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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METTL2A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

METTL2A Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

METTL2A Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.381204

Custom PCR Arrays for METTL2A

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for METTL2A
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		QuantiFast Probe-based Assays in human, mouse, rat METTL2A

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL2A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for METTL2A gene from Selected species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mettl2¹	methyltransferase like 2	83.06(n) 81.35(a)		52686 NM_172567.3 NP_766155.3
chicken (Gallus gallus)	Aves	METTL2A¹	methyltransferase like 2A	70.31(n) 69.19(a)		419948 NM_001006329.1 NP_001006329.1
lizard (Anolis carolinensis)	Reptilia	--	Uncharacterized protein	60(a)	1 → many	6(66014724-66028623)
African clawed frog (Xenopus laevis)	Amphibia	Xl.5270²	Xenopus laevis transcribed sequence with weak similarity more	73.44(n)		BU908164.1
zebrafish (Danio rerio)	Actinopterygii	Dr.25461²	Transcribed sequence with weak similarity to protein more	74.33(n)		CD759897.1
fruit fly (Drosophila melanogaster)	Insecta	metl¹	methyltransferase-like	57.45(n) 56.36(a)		38197 NM_139379.4 NP_647636.3
worm (Caenorhabditis elegans)	Secernentea	CELE_Y53F4B.42¹	CELE_Y53F4B.42	54.9(n) 51.4(a)		4363033 NM_001047362.2 NP_001040827.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	ABP140⁶	AdoMet-dependent tRNA methyltransferase and actin ...	21(a)	1 → many	XV(784857-786744) YOR239W

ENSEMBL Gene Tree for METTL2A (if available)
TreeFam Gene Tree for METTL2A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for METTL2A gene

METTL2B² METTL6² METTL8²

3 SIMAP similar genes for METTL2A using alignment to 1 protein entry: MET2A_HUMAN:

METTL2B FLJ13984 METTL8

Find genes that share paralogs with METTL2A About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs143492385^1,2		--	60499293(+)	`CTACTC/TGGGAG`	1	--	us2k¹		0	--	--	--	--
rs148016232^1,2	C	--	60499360(+)	`ATCACA/GCCACT`	1	--	us2k¹		0	--	--	--	--
rs141932667^1,2	C	--	60499389(+)	`CAGTGC/TGAGAC`	1	--	us2k¹		0	--	--	--	--
rs147290747^1,2		--	60499393(+)	`GCGAGA/GCTCCG`	1	--	us2k¹		0	--	--	--	--
rs192229262^1,2		--	60499570(+)	`TGGGAC/TTGTTG`	1	--	us2k¹		0	--	--	--	--
rs140933071^1,2	C	--	60499621(+)	`GCCCAC/TAGATG`	1	--	us2k¹		0	--	--	--	--
rs143269922^1,2	C	--	60499629(+)	`ATGAGA/TAAACA`	1	--	us2k¹		0	--	--	--	--
rs374098418^1,2	C	--	60499638(+)	`CAAGAC/TCCAGA`	1	--	us2k¹		0	--	--	--	--
rs375487881^1,2	C	--	60499683(+)	`AGCTG-/CCTTGA`	1	--	us2k¹		0	--	--	--	--
rs147548896^1,2		--	60499685(+)	`CTGGCC/TTTGAG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for METTL2A (60501228 - 60527454 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for METTL2A: About this table

Variant ID	Type	Subtype	PubMed ID
nsv908677	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing METTL2A

DNA2.0 Custom Variant and Variant Library Synthesis for METTL2A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for METTL2A gene, integrated from 10 sources (see all 14):
(articles sorted by number of sources associating them with METTL2A)

Utopia: connect your pdf to the dynamic
world of online information

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)^{1, 2} Zody M.C.... Nusbaum C. (Nature 2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)^{1, 2} Zhang Q.-H.... Chen Z. (Genome Res. 2000)
N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)² Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (Mol. Cell 2011)
Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (amp 2011)
A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (Sci Signal 2011)
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)² Gauci S....Mohammed S. (Anal. Chem. 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 339175	HGNC: 25755	AceView: FLJ12760	Ensembl:ENSG00000087995	euGenes: HUgn339175
ECgene: METTL2A	H-InvDB: METTL2A

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for METTL2A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for METTL2A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for METTL2A gene:
Search GeneIP for patents involving METTL2A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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	OriGene Antibodies for METTL2A		OriGene RNAi products in human, mouse, rat for METTL2A
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	Block miRNA regulation of human, mouse, rat METTL2A using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing METTL2A
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat METTL2A		Predesigned siRNA for gene silencing in human, mouse, rat METTL2A
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	Pre-validated RT² qPCR Primer Assay in human, mouse / rat METTL2A		Search GeneGlobe Interaction Network for METTL2A
	Regulatory tfbs in METTL2A promoter

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL2A

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL2A

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genOway: Develop your customized and physiologically relevant rodent model for METTL2A

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METTL2A Gene

Methyltransferase Like 2A

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METTL2A Gene

Methyltransferase Like 2A

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