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METTL2A Gene(Protein Coding)

Methyltransferase Like 2A

GCID:
GC17P062423
GIFtS:
45
Genes Participants
UDN Logo

Aliases for METTL2A Gene

Aliases for METTL2A Gene

  • Methyltransferase Like 2A 2 3 5
  • METTL2 3 4
  • EC 2.1.1.- 4

External Ids for METTL2A Gene

Previous GeneCards Identifiers for METTL2A Gene

  • GC17P057855
  • GC17P060501
  • GC17P055867

Summaries for METTL2A Gene

GeneCards Summary for METTL2A Gene

METTL2A (Methyltransferase Like 2A) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity and tRNA (cytosine) methyltransferase activity. An important paralog of this gene is METTL6.

UniProtKB/Swiss-Prot for METTL2A Gene

  • Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL2A Gene

Genomics for METTL2A Gene

Products:

  1. Regulatory Element

Regulatory Elements for METTL2A Gene

Enhancers for METTL2A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around METTL2A on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the METTL2A gene promoter:

Genomic Location for METTL2A Gene

Chromosome:
17
Start:
62,423,867 bp from pter
End:
62,450,822 bp from pter
Size:
26,956 bases
Orientation:
Plus strand

Genomic View for METTL2A Gene

Genes around METTL2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL2A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for METTL2A Gene

Proteins for METTL2A Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for METTL2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IZ6-MET2A_HUMAN
    Recommended name:
    Methyltransferase-like protein 2A
    Protein Accession:
    Q96IZ6
    Secondary Accessions:
    • A6NNC4
    • Q9H9G9
    • Q9NUI8
    • Q9P0B5

    Protein attributes for METTL2A Gene

    Size:
    378 amino acids
    Molecular mass:
    43537 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14260.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for METTL2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for METTL2A Gene

Proteomics data for METTL2A Gene at MOPED

Protein Expression for METTL2A Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for METTL2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for METTL2A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for METTL2A Gene

Domains & Families for METTL2A Gene

Gene Families for METTL2A Gene

HGNC:

Protein Domains for METTL2A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for METTL2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96IZ6

UniProtKB/Swiss-Prot:

MET2A_HUMAN :
  • Belongs to the methyltransferase superfamily. METL family.
Family:
  • Belongs to the methyltransferase superfamily. METL family.
genes like me logo Genes that share domains with METTL2A: view

Function for METTL2A Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for METTL2A Gene

UniProtKB/Swiss-Prot Function:
Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs.

Enzyme Numbers (IUBMB) for METTL2A Gene

Phenotypes for METTL2A Gene

GenomeRNAi human phenotypes for METTL2A:
genes like me logo Genes that share phenotypes with METTL2A: view

Animal Model Products

CRISPR Products

miRNA for METTL2A Gene

miRTarBase miRNAs that target METTL2A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL2A Gene

Localization for METTL2A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for METTL2A Gene COMPARTMENTS Subcellular localization image for METTL2A gene
Compartment Confidence
cytosol 3
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for METTL2A Gene

Pathways & Interactions for METTL2A Gene

SuperPathways for METTL2A Gene

PathCards logoMore details on SuperPathways for METTL2A
No Data Available

Interacting Proteins for METTL2A Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000309610%0d%0a9606.ENSP00000283943%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000430236%0d%0a9606.ENSP00000382269%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: Q96IZ6-MET2A_HUMAN ENSP00000309610 for METTL2A Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for METTL2A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for METTL2A Gene

Drugs & Compounds for METTL2A Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for METTL2A Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for METTL2A Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(139) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for METTL2A Gene

Methyltransferase like 2A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL2A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1:
SP2:

Relevant External Links for METTL2A Gene

GeneLoc Exon Structure for
METTL2A
ECgene alternative splicing isoforms for
METTL2A

Expression for METTL2A Gene

Products:

  1. Primer

mRNA expression in normal human tissues for METTL2A Gene

mRNA expression in normal human tissues for METTL2A Gene
mRNA expression by BioGPS for METTL2A GenemRNA expression by GTEx for METTL2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for METTL2A Gene

This gene is overexpressed in Fetal Liver (28.3), Fetal ovary (24.4), and Fetal heart (15.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for METTL2A Gene



SOURCE GeneReport for Unigene cluster for METTL2A Gene Hs.381204

genes like me logo Genes that share expression patterns with METTL2A: view

Protein tissue co-expression partners for METTL2A Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for METTL2A Gene

Orthologs for METTL2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for METTL2A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia METTL2B 35
  • 87.02 (n)
  • 86.13 (a)
METTL2 36
  • 84 (a)
 OneToMany
dog
(Canis familiaris)
 Mammalia METTL2A 35
  • 88.89 (n)
  • 88.62 (a)
-- 36
  • 63 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Mettl2 35
  • 83.06 (n)
  • 81.35 (a)
Mettl2 16
Mettl2 36
  • 76 (a)
 OneToMany
chimpanzee
(Pan troglodytes)
 Mammalia METTL2A 35
  • 98.94 (n)
  • 98.14 (a)
METTL2A 36
  • 98 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Mettl2b 35
  • 83.11 (n)
  • 82.04 (a)
oppossum
(Monodelphis domestica)
 Mammalia -- 36
  • 74 (a)
 OneToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 36
  • 66 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves METTL2A 35
  • 70.31 (n)
  • 69.19 (a)
METTL2 36
  • 65 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 36
  • 60 (a)
 OneToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia mettl2b 35
  • 68.11 (n)
  • 70.68 (a)
Str.3463 35
African clawed frog
(Xenopus laevis)
 Amphibia Xl.5270 35
zebrafish
(Danio rerio)
 Actinopterygii Dr.25461 35
mettl2a 35
  • 70.72 (n)
  • 74.14 (a)
mettl2a 36
  • 66 (a)
 OneToMany
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP005973 35
  • 56.37 (n)
  • 56.37 (a)
fruit fly
(Drosophila melanogaster)
 Insecta metl 35
  • 57.45 (n)
  • 56.36 (a)
metl 36
  • 49 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea CELE_Y53F4B.42 35
  • 54.9 (n)
  • 51.4 (a)
Y53F4B.42 36
  • 48 (a)
 OneToMany
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0F11385g 35
  • 50.96 (n)
  • 49.64 (a)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes ABP140 36
  • 21 (a)
 OneToMany
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.4466 35
bread mold
(Neurospora crassa)
 Ascomycetes NCU04647 35
  • 51.27 (n)
  • 44.36 (a)
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes SPBC21C3.07c 35
  • 52.89 (n)
  • 47.23 (a)
Species with no ortholog for METTL2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL2A Gene

ENSEMBL:
Gene Tree for METTL2A (if available)
TreeFam:
Gene Tree for METTL2A (if available)

Paralogs for METTL2A Gene

Paralogs for METTL2A Gene

(3) SIMAP similar genes for METTL2A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with METTL2A: view

Variants for METTL2A Gene

Sequence variations from dbSNP and Humsavar for METTL2A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1053119 -- 62,426,438(+) AAGGA(C/T)TGGTT reference, synonymous-codon
rs1053125 -- 62,448,633(+) GTGGA(C/T)CGCCG reference, synonymous-codon
rs1053126 -- 62,448,657(+) CGAGG(A/G)AAGCA reference, synonymous-codon
rs1053127 -- 62,448,728(+) CAGCT(A/G)AGAGG reference, synonymous-codon
rs1053128 -- 62,448,761(+) AGCCC(A/G)TTGTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for METTL2A Gene

Variant ID Type Subtype PubMed ID
nsv908677 CNV Gain 21882294

Variation tolerance for METTL2A Gene

Residual Variation Intolerance Score: 71.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.14; 38.95% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for METTL2A Gene

Disorders for METTL2A Gene

Relevant External Links for METTL2A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
METTL2A

No disorders were found for METTL2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL2A Gene

Publications for METTL2A Gene

  1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  4. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for METTL2A Gene

Sources for METTL2A Gene

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