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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

METTL2A Gene

protein-coding GIFtS: 42
GCID: GC17P060501

Methyltransferase Like 2A

Search for METTL2A
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Methyltransferase Like 2A¹ ²
METTL2² ³
Methyltransferase-Like Protein 2A²
EC 2.1.1.-³

External Ids:	HGNC: 25755¹	Entrez Gene: 339175²	Ensembl: ENSG00000087995⁷	UniProtKB: Q96IZ6³

Export aliases for METTL2A gene to outside databases

Previous GC identifers: GC17P057855 GC17P055867

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for METTL2A Gene:

METTL2A (methyltransferase like 2A) is a protein-coding gene. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is METTL2B.

UniProtKB/Swiss-Prot: MET2A_HUMAN, Q96IZ6

Function: Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of

some tRNAs (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NT_010783.15 NC_018928.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the METTL2A gene promoter:
TBP RP58 AML1a HSF1 (long) E47 FOXO4 TFIID HSF1short RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: METTL2A promoter sequence

Search SABiosciences Chromatin IP Primers for METTL2A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL2A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.2 Ensembl cytogenetic band: 17q23.2 HGNC cytogenetic band: 17q23.3

METTL2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
METTL2A gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P060501: view genomic region (about GC identifiers)

Start:	60,501,228 bp from pter	End:	60,527,454 bp from pter
Size:	26,227 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MET2A_HUMAN, Q96IZ6 (See protein sequence)

Recommended Name: Methyltransferase-like protein 2A

Size: 378 amino acids; 43537 Da

Sequence caution: Sequence=BAB14260.1; Type=Erroneous initiation;

Secondary accessions: A6NNC4 Q9H9G9 Q9NUI8 Q9P0B5

Alternative splicing: 2 isoforms: Q96IZ6-1 Q96IZ6-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for METTL2A: NX_Q96IZ6

Explore proteomics data for METTL2A at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q96IZ6

METTL2A Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_859076.3

ENSEMBL proteins:

ENSP00000309610

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

1 InterPro protein domain:

IPR026113 MeTrfase

Graphical View of Domain Structure for InterPro Entry Q96IZ6

ProtoNet protein and cluster: Q96IZ6

UniProtKB/Swiss-Prot: MET2A_HUMAN, Q96IZ6

Similarity: Belongs to the methyltransferase superfamily. METL family

METTL2A for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MET2A_HUMAN, Q96IZ6

Function: Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of

some tRNAs (By similarity)

Enzyme Number (IUBMB): EC 2.1.1.-¹

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008168	methyltransferase activity	--	--
GO:0016427	tRNA (cytosine) methyltransferase activity	ISS	--

METTL2A for ontologies About GeneDecksing

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL2A

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for METTL2A

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

3 Interacting proteins for METTL2A (Q96IZ6^{2, 3} ENSP00000309610⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAPK6	Q16659²^,³	MINT-8261450 I2D: score=2
UBC	ENSP00000344818⁴	STRING: ENSP00000344818
ELAVL1	ENSP00000385269⁴	STRING: ENSP00000385269

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008152	metabolic process	--	--
GO:0030488	tRNA methylation	ISS	--

METTL2A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for METTL2A gene (2 alternative transcripts):

NM_001005372.1 NM_181725.3

Unigene Cluster for METTL2A:

Methyltransferase like 2A

Hs.381204 [show with all ESTs]

Unigene Representative Sequence: NM_181725

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000311506(uc002izv.2 uc002izw.3) ENST00000333483 ENST00000582027

miRNA Products:
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Additional mRNA sequence:

AF161384.1 AF161385.1 AK000991.1 AK022822.1 BC006985.1

14 DOTS entries:

DT.95225403 DT.95225363 DT.100030093 DT.95225366 DT.120934902 DT.120934877 DT.92440304 DT.100818209

DT.65288274 DT.95225364 DT.120934872 DT.92440296 DT.95225353 DT.95338521

24/139 AceView cDNA sequences (see all 139):

AA339213 BU182023 AI621120 BE792117 BE856364 CR595349 AA632217 AI632244

CA441076 N35537 BG574337 BQ000496 BM756383 BG403117 BV204792 BV204789

BM450914 BG504411 BI489386 BM764785 BG476411 CA310480 BU506863 BM451521

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for METTL2A About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b
SP1:
SP2:

ECgene alternative splicing isoforms for METTL2A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

METTL2A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

See METTL2A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for METTL2A

SOURCE GeneReport for Unigene cluster: Hs.381204

SABiosciences Custom PCR Arrays for METTL2A

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for METTL2A gene from 8/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mettl2¹	methyltransferase like 2	82.21(n) 80.86(a)		52686 NM_172567.3 NP_766155.3
chicken (Gallus gallus)	Aves	METTL2A¹	methyltransferase like 2A	70.22(n) 69.1(a)		419948 NM_001006329.1 NP_001006329.1
lizard (Anolis carolinensis)	Reptilia	--	Uncharacterized protein	59(a)	1 → many	6(66014724-66028623)
African clawed frog (Xenopus laevis)	Amphibia	Xl.5270²	Xenopus laevis transcribed sequence with weak similarity more	73.44(n)		BU908164.1
zebrafish (Danio rerio)	Actinopterygii	Dr.25461²	Transcribed sequence with weak similarity to protein more	74.33(n)		CD759897.1
fruit fly (Drosophila melanogaster)	Insecta	metl¹	methyltransferase-like	58.16(n) 56.29(a)		38197 NM_167907.2 NP_728647.2
worm (Caenorhabditis elegans)	Secernentea	CELE_Y53F4B.42¹	Protein Y53F4B.42	54.83(n) 51.03(a)		4363033 NM_001047362.1 NP_001040827.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	ABP140¹	Abp140p	51.48(n) 45.91(a)		854414 NP_014882.4

ENSEMBL Gene Tree for METTL2A (if available)
TreeFam Gene Tree for METTL2A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for METTL2A gene

METTL2B² METTL6² METTL8²

3 SIMAP similar genes for METTL2A using alignment to 1 protein entry: MET2A_HUMAN:

METTL2B FLJ13984 METTL8

METTL2A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs143492385^1,2		--	60499293(+)	`CTACTC/TGGGAG`	1	--	us2k¹		0	--	--	--	--
rs148016232^1,2	C	--	60499360(+)	`ATCACA/GCCACT`	1	--	us2k¹		0	--	--	--	--
rs141932667^1,2	C	--	60499389(+)	`CAGTGC/TGAGAC`	1	--	us2k¹		0	--	--	--	--
rs147290747^1,2		--	60499393(+)	`GCGAGA/GCTCCG`	1	--	us2k¹		0	--	--	--	--
rs192229262^1,2		--	60499570(+)	`TGGGAC/TTGTTG`	1	--	us2k¹		0	--	--	--	--
rs140933071^1,2	C	--	60499621(+)	`GCCCAC/TAGATG`	1	--	us2k¹		0	--	--	--	--
rs143269922^1,2	C	--	60499629(+)	`ATGAGA/TAAACA`	1	--	us2k¹		0	--	--	--	--
rs374098418^1,2	C	--	60499638(+)	`CAAGAC/TCCAGA`	1	--	us2k¹		0	--	--	--	--
rs375487881^1,2	C	--	60499683(+)	`AGCTG-/CCTTGA`	1	--	us2k¹		0	--	--	--	--
rs147548896^1,2		--	60499685(+)	`CTGGCC/TTTGAG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for METTL2A (60501228 - 60527454 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for METTL2A: About this table

Variant ID	Type	Subtype	PubMed ID
nsv908677	CNV	Gain	21882294

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for METTL2A gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with METTL2A)

Utopia: connect your pdf to the dynamic
world of online information

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)^{1, 2} Zody M.C.... Nusbaum C. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)^{1, 2} Zhang Q.-H.... Chen Z. (2000)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (2011)
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)² Gauci S....Mohammed S. (2009)
Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 339175	HGNC: 25755	AceView: FLJ12760	Ensembl:ENSG00000087995	euGenes: HUgn339175
ECgene: METTL2A	H-InvDB: METTL2A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for METTL2A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for METTL2A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for METTL2A gene:
Search GeneIP for patents involving METTL2A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013

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Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
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METTL2A Gene

Methyltransferase Like 2A

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METTL2A Gene

Methyltransferase Like 2A

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