Aliases for METTL2A Gene
Aliases for METTL2A Gene
External Ids for METTL2A Gene
- HGNC: 25755
- Entrez Gene: 339175
- Ensembl: ENSG00000087995
- UniProtKB: Q96IZ6
Previous GeneCards Identifiers for METTL2A Gene
- GC17P057855
- GC17P060501
- GC17P055867
Summaries for METTL2A Gene
GeneCards Summary for METTL2A Gene
METTL2A (Methyltransferase Like 2A) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity and tRNA (cytosine) methyltransferase activity. An important paralog of this gene is METTL2B.
UniProtKB/Swiss-Prot for METTL2A Gene
-
Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL2A Gene
Genomics for METTL2A Gene
Regulatory Elements for METTL2A Gene
Enhancers for METTL2A Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH17G062477 | 1.3 | ENCODE dbSUPER | 4.7 | +55.3 | 55302 | 3.7 | SIN3A ZNF48 ZBTB7B YY1 GLIS2 ELK1 CBX5 SP3 CEBPZ MXD4 | MED13 MRC2 METTL2A INTS2 TLK2 RPS10P26 |
| GH17G062616 | 1.2 | Ensembl ENCODE | 4.3 | +194.8 | 194753 | 3.4 | FOXA2 MLX ARID4B NFXL1 DMAP1 ZBTB7B RARA GATA2 SCRT2 ETV6 | MRC2 METTL2A GC17P062611 ENSG00000277463 |
| GH17G062489 | 0.5 | dbSUPER | 4.8 | +67.0 | 66986 | 2.3 | ZNF316 MAFG NR2F6 NFXL1 EMSY | MRC2 METTL2A INTS2 RPS10P26 TLK2 |
| GH17G062423 | 1.1 | ENCODE | 0.7 | +0.3 | 264 | 1.6 | HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 | METTL2A PIR60058 |
| GH17G062421 | 0.8 | Ensembl | 0.7 | -2.2 | -2167 | 0.2 | CTCF CREB3L1 NFIB SUZ12 ZIC2 ZNF2 ZBTB7B RAD21 CTBP1 SMC3 | MRC2 METTL2A PIR38858 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around METTL2A on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the METTL2A gene promoter:
Regulatory Element Products
Genomic Location for METTL2A Gene
- Chromosome:
- 17
- Start:
- 62,423,867 bp from pter
- End:
- 62,450,822 bp from pter
- Size:
- 26,956 bases
- Orientation:
- Plus strand
Genomic View for METTL2A Gene
Genes around METTL2A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q23.2 by Ensembl
- 17q23.2 by Entrez Gene
- 17q23.2 by HGNC
METTL2A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for METTL2A Gene
Proteins for METTL2A Gene
-
Protein details for METTL2A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96IZ6-MET2A_HUMAN
- Recommended name:
- Methyltransferase-like protein 2A
- Protein Accession:
- Q96IZ6
- A6NNC4
- Q9H9G9
- Q9NUI8
- Q9P0B5
Protein attributes for METTL2A Gene
- Size:
- 378 amino acids
- Molecular mass:
- 43537 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAB14260.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for METTL2A Gene
Post-translational modifications for METTL2A Gene
Other Protein References for METTL2A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for METTL2A
- Novus Biologicals Antibodies for METTL2A
-
Abcam antibodies for METTL2A
- antibodies-online Antibodies for METTL2A: See all 10
- Search GeneTex for Antibodies for METTL2A
Protein Products
-
OriGene Purified Proteins for METTL2A
- Search Origene for MassSpec and Protein Over-expression Lysates for METTL2A
- Origene Custom Protein Services for METTL2A
- Novus Biologicals lysates for METTL2A
- Search GeneTex for Proteins for METTL2A
No data available for DME Specific Peptides for METTL2A Gene
Domains & Families for METTL2A Gene
Gene Families for METTL2A Gene
Protein Domains for METTL2A Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for METTL2A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96IZ6- Family:
-
- Belongs to the methyltransferase superfamily. METL family.
Function for METTL2A Gene
Molecular function for METTL2A Gene
- UniProtKB/Swiss-Prot Function:
- Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs.
Enzyme Numbers (IUBMB) for METTL2A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016427 | tRNA (cytosine) methyltransferase activity | ISS | -- |
| GO:0016740 | transferase activity | IEA | -- |
Phenotypes for METTL2A Gene
- GenomeRNAi human phenotypes for METTL2A:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for METTL2A
-
-
ViGene Biosciences lentiviral particle packaged cDNA for METTL2A gene
-
ViGene Biosciences ready-to-package AAV shRNAs for METTL2A gene
- Search ViGene Biosciences for METTL2A
CRISPR Products
-
OriGene CRISPR knockouts for METTL2A
-
Santa Cruz Biotechnology (SCBT) CRISPR for METTL2A
- GenScript: Design CRISPR guide RNA sequences for METTL2A
miRNA for METTL2A Gene
- miRTarBase miRNAs that target METTL2A
miRNA Products
- Search ViGene Biosciences for METTL2A
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for METTL2A
- Browse OriGene Inhibitory RNA Products For METTL2A
-
ViGene Biosciences ready-to-package AAV shRNAs for METTL2A gene
Clone Products
- Sino Biological Human cDNA Clone for METTL2A
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for METTL2A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for METTL2A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for METTL2A
-
ViGene Biosciences adenoviral particle packaged cDNA for METTL2A gene
-
ViGene Biosciences lentiviral particle packaged cDNA for METTL2A gene
-
ViGene Biosciences ready-to-package AAV shRNAs for METTL2A gene
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL2A Gene
Localization for METTL2A Gene
| Compartment | Confidence |
|---|---|
| cytosol | 3 |
| mitochondrion | 1 |
| peroxisome | 1 |
| nucleus | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for METTL2A Gene
Pathways & Interactions for METTL2A Gene
No Data Available
Interacting Proteins for METTL2A Gene
Selected Interacting proteins:
Q96IZ6-MET2A_HUMAN
ENSP00000309610
for METTL2A Gene via
MINT
STRING
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0030488 | tRNA methylation | ISS | -- |
| GO:0032259 | methylation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for METTL2A Gene
Transcripts for METTL2A Gene
mRNA/cDNA for METTL2A Gene
- (3) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (139) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for METTL2A Gene
CRISPR Products
-
OriGene CRISPR knockouts for METTL2A
-
Santa Cruz Biotechnology (SCBT) CRISPR for METTL2A
- GenScript: Design CRISPR guide RNA sequences for METTL2A
miRNA Products
- Search ViGene Biosciences for METTL2A
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for METTL2A
- Browse OriGene Inhibitory RNA Products For METTL2A
-
ViGene Biosciences ready-to-package AAV shRNAs for METTL2A gene
Clone Products
- Sino Biological Human cDNA Clone for METTL2A
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for METTL2A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for METTL2A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||
| SP2: |
Expression for METTL2A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
- Eye (Sensory Organs)
This gene is overexpressed in Fetal Liver (28.3), Fetal ovary (24.4), and Fetal heart (15.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for METTL2A Gene
NURSA nuclear receptor signaling pathways regulating expression of METTL2A Gene:
METTL2ASOURCE GeneReport for Unigene cluster for METTL2A Gene:
Hs.381204Evidence on tissue expression from TISSUES for METTL2A Gene
- Nervous system(4.4)
- Blood(4)
Primer Products
-
OriGene qPCR primer pairs for METTL2A
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL2A Gene
Orthologs for METTL2A Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | METTL2A 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | METTL2A 34 |
|
||
| -- 35 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | METTL2B 34 |
|
||
| METTL2 35 |
|
OneToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Mettl2b 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Mettl2 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | METTL2A 34 |
|
||
| METTL2 35 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mettl2b 34 |
|
||
| Str.3463 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.5270 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mettl2a 34 35 |
|
||
| Dr.25461 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | metl 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005973 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | CELE_Y53F4B.42 34 |
|
||
| Y53F4B.42 35 |
|
OneToMany | |||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F11385g 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ABP140 35 |
|
OneToMany | |
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPBC21C3.07c 34 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU04647 34 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.4466 34 |
|
- Species where no ortholog for METTL2A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for METTL2A Gene
Variants for METTL2A Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000205750 | -- | 62,422,156(+) | TAATA(C/T)AGTAA | upstream-variant-2KB | |
| rs1000377396 | -- | 62,439,507(+) | CAGCT(C/T)ACTGA | intron-variant | |
| rs1000431522 | -- | 62,427,286(+) | CTCTG(C/T)ACTTT | intron-variant | |
| rs1000553319 | -- | 62,444,322(+) | CGGCC(C/T)AGGCC | intron-variant | |
| rs1000605822 | -- | 62,444,710(+) | GTAGA(A/G)GAGCT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3640974 | CNV | gain | 21293372 |
| esv3640975 | CNV | loss | 21293372 |
| nsv962358 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
71.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.14;
38.95% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for METTL2A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- METTL2A
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL2A Gene
Disorders for METTL2A Gene
Relevant External Links for METTL2A
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- METTL2A
No disorders were found for METTL2A Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL2A Gene
Publications for METTL2A Gene
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4 64
Products for METTL2A Gene
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- Custom Antibody ServicesOriGene Antibodies for METTL2A
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- OriGene qPCR primer pairs for METTL2A
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- GenScript: Next-day shipping cDNA ORF clone for METTL2A in any vector
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- GenScript: Design CRISPR guide RNA sequences for METTL2A
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- CloneReady with Over 120,000 Genes
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- Novus Biologicals Antibodies for METTL2A
- Novus Biologicals lysates for METTL2A
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for METTL2A
- Find your target
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- ViGene Biosciences adenoviral particle packaged cDNA for METTL2A gene
- ViGene Biosciences lentiviral particle packaged cDNA for METTL2A gene
- ViGene Biosciences ready-to-package AAV shRNAs for METTL2A gene
- Search ViGene Biosciences for METTL2A
- Horizon Cell Lines for METTL2A
- Cyagen custom Knockout/knockin (KOKI) mouse models for METTL2A
- VectorBuilder custom plasmid, inducible vectors for METTL2A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for METTL2A
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for METTL2A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
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- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
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- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer