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Aliases for METTL25 Gene

Aliases for METTL25 Gene

  • Methyltransferase Like 25 2 3
  • C12orf26 3 4
  • Chromosome 12 Open Reading Frame 26 2
  • Methyltransferase-Like Protein 25 3
  • EC 2.1.1.- 4

External Ids for METTL25 Gene

Previous HGNC Symbols for METTL25 Gene

  • C12orf26

Previous GeneCards Identifiers for METTL25 Gene

  • GC12P082754

Summaries for METTL25 Gene

GeneCards Summary for METTL25 Gene

METTL25 (Methyltransferase Like 25) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is RRNAD1.

UniProtKB/Swiss-Prot for METTL25 Gene

  • Putative methyltransferase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL25 Gene

Genomics for METTL25 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for METTL25 Gene

82,358,497 bp from pter
82,479,239 bp from pter
120,743 bases
Plus strand

Genomic View for METTL25 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for METTL25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL25 Gene

No data available for Regulatory Elements for METTL25 Gene

Proteins for METTL25 Gene

  • Protein details for METTL25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Methyltransferase-like protein 25
    Protein Accession:
    Secondary Accessions:
    • Q9H5Y3

    Protein attributes for METTL25 Gene

    603 amino acids
    Molecular mass:
    68213 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB15484.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for METTL25 Gene

Proteomics data for METTL25 Gene at MOPED

Post-translational modifications for METTL25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for METTL25 Gene

No data available for DME Specific Peptides for METTL25 Gene

Domains for METTL25 Gene

Gene Families for METTL25 Gene

Protein Domains for METTL25 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with METTL25: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for METTL25 Gene

Function for METTL25 Gene

Molecular function for METTL25 Gene

UniProtKB/Swiss-Prot Function:
Putative methyltransferase.

Enzyme Numbers (IUBMB) for METTL25 Gene

Gene Ontology (GO) - Molecular Function for METTL25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with METTL25: view

Phenotypes for METTL25 Gene

GenomeRNAi human phenotypes for METTL25:
genes like me logo Genes that share phenotypes with METTL25: view

Animal Model Products

CRISPR Products

miRNA for METTL25 Gene

miRTarBase miRNAs that target METTL25

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for METTL25

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for METTL25 Gene

Localization for METTL25 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for METTL25 Gene

Pathways for METTL25 Gene

SuperPathways for METTL25 Gene

No Data Available

Interacting Proteins for METTL25 Gene

Selected Interacting proteins: Q8N6Q8-MET25_HUMAN for METTL25 Gene via I2D

Gene Ontology (GO) - Biological Process for METTL25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL25: view

No data available for Pathways by source for METTL25 Gene

Transcripts for METTL25 Gene

Unigene Clusters for METTL25 Gene

Methyltransferase like 25:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for METTL25

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL25 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP2: - - - -
SP3: -
SP4: - - -
SP6: - -

Relevant External Links for METTL25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL25 Gene

mRNA expression in normal human tissues for METTL25 Gene

Protein differential expression in normal tissues for METTL25 Gene

This gene is overexpressed in Bone marrow stromal cell (33.4) and Peripheral blood mononuclear cells (26.4).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for METTL25 Gene

SOURCE GeneReport for Unigene cluster for METTL25 Gene Hs.506222

genes like me logo Genes that share expressions with METTL25: view

Expression partners for METTL25 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for METTL25 Gene

Orthologs for METTL25 Gene

This gene was present in the common ancestor of animals.

Orthologs for METTL25 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia METTL25 35
  • 77.31 (n)
  • 72.1 (a)
METTL25 36
  • 73 (a)
(Canis familiaris)
Mammalia METTL25 35
  • 88.1 (n)
  • 84.88 (a)
C12ORF26 36
  • 85 (a)
(Mus musculus)
Mammalia Mettl25 35
  • 80.8 (n)
  • 76.35 (a)
Mettl25 16
Mettl25 36
  • 75 (a)
(Pan troglodytes)
Mammalia METTL25 35
  • 99.23 (n)
  • 99.5 (a)
METTL25 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mettl25 35
  • 79.53 (n)
  • 75.5 (a)
(Monodelphis domestica)
Mammalia METTL25 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 49 (a)
-- 36
  • 83 (a)
(Gallus gallus)
Aves C1H12ORF26 35
  • 68.95 (n)
  • 63.51 (a)
METTL25 36
  • 58 (a)
(Anolis carolinensis)
Reptilia METTL25 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl25 35
  • 60.83 (n)
  • 54.16 (a)
Str.14343 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.13226 35
(Danio rerio)
Actinopterygii Dr.17382 35
mettl25 35
  • 56.03 (n)
  • 49.91 (a)
mettl25 36
  • 46 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010960 35
  • 44.7 (n)
  • 36.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33964 35
  • 27.32 (n)
  • 8.92 (a)
CG33964 36
  • 30 (a)
Species with no ortholog for METTL25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for METTL25 Gene

Gene Tree for METTL25 (if available)
Gene Tree for METTL25 (if available)

Paralogs for METTL25 Gene

Paralogs for METTL25 Gene

genes like me logo Genes that share paralogs with METTL25: view

Variants for METTL25 Gene

Sequence variations from dbSNP and Humsavar for METTL25 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs955714 -- 82,467,955(+) tccca(C/G)aaagc intron-variant
rs963873 -- 82,455,273(+) CATAA(G/T)ATATA intron-variant
rs1021486 -- 82,435,139(-) AACTA(A/T)TGGTT intron-variant
rs1353176 -- 82,468,186(-) AGTGG(A/T)CTGGA intron-variant
rs1353177 -- 82,467,761(-) tctat(A/C)caagg intron-variant

Relevant External Links for METTL25 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for METTL25 Gene

Disorders for METTL25 Gene

No disorders were found for METTL25 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for METTL25 Gene

Publications for METTL25 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for METTL25 Gene

Sources for METTL25 Gene

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