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Aliases for METTL25 Gene

Aliases for METTL25 Gene

  • Methyltransferase Like 25 2 3 5
  • C12orf26 3 4
  • Chromosome 12 Open Reading Frame 26 2
  • EC 2.1.1.- 4

External Ids for METTL25 Gene

Previous HGNC Symbols for METTL25 Gene

  • C12orf26

Previous GeneCards Identifiers for METTL25 Gene

  • GC12P082754

Summaries for METTL25 Gene

GeneCards Summary for METTL25 Gene

METTL25 (Methyltransferase Like 25) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is RRNAD1.

UniProtKB/Swiss-Prot for METTL25 Gene

  • Putative methyltransferase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL25 Gene

Genomics for METTL25 Gene

Regulatory Elements for METTL25 Gene

Promoters for METTL25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around METTL25 on UCSC Golden Path with GeneCards custom track

Genomic Location for METTL25 Gene

82,358,406 bp from pter
82,479,239 bp from pter
120,834 bases
Plus strand

Genomic View for METTL25 Gene

Genes around METTL25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL25 Gene

Proteins for METTL25 Gene

  • Protein details for METTL25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Methyltransferase-like protein 25
    Protein Accession:
    Secondary Accessions:
    • Q9H5Y3

    Protein attributes for METTL25 Gene

    603 amino acids
    Molecular mass:
    68213 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB15484.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for METTL25 Gene

Proteomics data for METTL25 Gene at MOPED

Post-translational modifications for METTL25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for METTL25 Gene

No data available for DME Specific Peptides for METTL25 Gene

Domains & Families for METTL25 Gene

Gene Families for METTL25 Gene

Protein Domains for METTL25 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with METTL25: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for METTL25 Gene

Function for METTL25 Gene

Molecular function for METTL25 Gene

UniProtKB/Swiss-Prot Function:
Putative methyltransferase.

Enzyme Numbers (IUBMB) for METTL25 Gene

Phenotypes for METTL25 Gene

GenomeRNAi human phenotypes for METTL25:
genes like me logo Genes that share phenotypes with METTL25: view

Animal Model Products

CRISPR Products

miRNA for METTL25 Gene

miRTarBase miRNAs that target METTL25

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL25 Gene

Localization for METTL25 Gene

Subcellular locations from

Jensen Localization Image for METTL25 Gene COMPARTMENTS Subcellular localization image for METTL25 gene
Compartment Confidence
cytosol 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for METTL25 Gene

Pathways & Interactions for METTL25 Gene

SuperPathways for METTL25 Gene

No Data Available

Interacting Proteins for METTL25 Gene

Selected Interacting proteins: Q8N6Q8-MET25_HUMAN for METTL25 Gene via I2D

Gene Ontology (GO) - Biological Process for METTL25 Gene


No data available for Pathways by source and SIGNOR curated interactions for METTL25 Gene

Drugs & Compounds for METTL25 Gene

No Compound Related Data Available

Transcripts for METTL25 Gene

Unigene Clusters for METTL25 Gene

Methyltransferase like 25:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for METTL25 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP2: - - - -
SP3: -
SP4: - - -
SP6: - -

Relevant External Links for METTL25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL25 Gene

mRNA expression in normal human tissues for METTL25 Gene

Protein differential expression in normal tissues from HIPED for METTL25 Gene

This gene is overexpressed in Bone marrow stromal cell (33.4) and Peripheral blood mononuclear cells (26.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for METTL25 Gene

SOURCE GeneReport for Unigene cluster for METTL25 Gene Hs.506222

genes like me logo Genes that share expression patterns with METTL25: view

Protein tissue co-expression partners for METTL25 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for METTL25 Gene

Orthologs for METTL25 Gene

This gene was present in the common ancestor of animals.

Orthologs for METTL25 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia METTL25 35
  • 77.31 (n)
  • 72.1 (a)
METTL25 36
  • 73 (a)
(Canis familiaris)
Mammalia METTL25 35
  • 88.1 (n)
  • 84.88 (a)
C12ORF26 36
  • 85 (a)
(Mus musculus)
Mammalia Mettl25 35
  • 80.8 (n)
  • 76.35 (a)
Mettl25 16
Mettl25 36
  • 75 (a)
(Pan troglodytes)
Mammalia METTL25 35
  • 99.23 (n)
  • 99.5 (a)
METTL25 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mettl25 35
  • 79.53 (n)
  • 75.5 (a)
(Monodelphis domestica)
Mammalia METTL25 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 49 (a)
-- 36
  • 83 (a)
(Gallus gallus)
Aves C1H12ORF26 35
  • 68.95 (n)
  • 63.51 (a)
METTL25 36
  • 58 (a)
(Anolis carolinensis)
Reptilia METTL25 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl25 35
  • 60.83 (n)
  • 54.16 (a)
Str.14343 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.13226 35
(Danio rerio)
Actinopterygii Dr.17382 35
mettl25 35
  • 56.03 (n)
  • 49.91 (a)
mettl25 36
  • 46 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010960 35
  • 44.7 (n)
  • 36.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33964 35
  • 27.32 (n)
  • 8.92 (a)
CG33964 36
  • 30 (a)
Species with no ortholog for METTL25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for METTL25 Gene

Gene Tree for METTL25 (if available)
Gene Tree for METTL25 (if available)

Paralogs for METTL25 Gene

Paralogs for METTL25 Gene

genes like me logo Genes that share paralogs with METTL25: view

Variants for METTL25 Gene

Sequence variations from dbSNP and Humsavar for METTL25 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs4296098 - 82,399,008(+) AAGTG(A/C)AAAAT nc-transcript-variant, reference, missense
rs955714 -- 82,467,955(+) tccca(C/G)aaagc intron-variant
rs963873 -- 82,455,273(+) CATAA(G/T)ATATA intron-variant
rs1021486 -- 82,435,139(-) AACTA(A/T)TGGTT intron-variant
rs1494023 -- 82,470,139(-) TTTAA(A/G)TCCTA intron-variant

Variation tolerance for METTL25 Gene

Residual Variation Intolerance Score: 36.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.61; 65.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for METTL25 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for METTL25 Gene

Disorders for METTL25 Gene

Relevant External Links for METTL25

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for METTL25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL25 Gene

Publications for METTL25 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for METTL25 Gene

Sources for METTL25 Gene

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