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Aliases for METTL25 Gene

Aliases for METTL25 Gene

  • Methyltransferase Like 25 2 3 5
  • C12orf26 3 4
  • Chromosome 12 Open Reading Frame 26 2
  • Methyltransferase-Like Protein 25 3
  • EC 2.1.1.- 4

External Ids for METTL25 Gene

Previous HGNC Symbols for METTL25 Gene

  • C12orf26

Previous GeneCards Identifiers for METTL25 Gene

  • GC12P082754

Summaries for METTL25 Gene

GeneCards Summary for METTL25 Gene

METTL25 (Methyltransferase Like 25) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include methyltransferase activity. An important paralog of this gene is RRNAD1.

UniProtKB/Swiss-Prot for METTL25 Gene

  • Putative methyltransferase.

Additional gene information for METTL25 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL25 Gene

Genomics for METTL25 Gene

GeneHancer (GH) Regulatory Elements for METTL25 Gene

Promoters and enhancers for METTL25 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I082357 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 604.8 +0.0 37 2.8 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 METTL25 CCDC59 PIR52845 ENSG00000257431
GH12I082861 Enhancer 0.9 dbSUPER 13.8 +504.9 504855 2.9 PKNOX1 ARNT ZSCAN4 INSM2 MZF1 FEZF1 ZNF2 ZNF121 ZNF213 ZNF138 METTL25 CCDC59 PIR32311 PIR35845 TMTC2
GH12I081381 Enhancer 0.7 dbSUPER 16.7 -975.8 -975801 1.2 NCOA3 SOX13 PKNOX1 ESRRA FOXA2 NFIB NEUROD1 BMI1 ZNF507 MTA3 METTL25 PPFIA2 ENSG00000258162 GC12P081435
GH12I082314 Enhancer 0.7 Ensembl 0.3 -43.8 -43792 0.4 ELF3 FOXA2 ARID4B CEBPG ZNF644 E2F1 GATAD2A SOX5 RFX1 SP5 LOC105369873 METTL25 CCDC59
GH12I082329 Enhancer 0.4 ENCODE 0.3 -28.6 -28638 0.6 PRDM6 ZNF384 FEZF1 ENSG00000257431 LOC105369873 METTL25 CCDC59
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around METTL25 on UCSC Golden Path with GeneCards custom track

Genomic Locations for METTL25 Gene

Genomic Locations for METTL25 Gene
120,834 bases
Plus strand

Genomic View for METTL25 Gene

Genes around METTL25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL25 Gene

Proteins for METTL25 Gene

  • Protein details for METTL25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Methyltransferase-like protein 25
    Protein Accession:
    Secondary Accessions:
    • Q9H5Y3

    Protein attributes for METTL25 Gene

    603 amino acids
    Molecular mass:
    68213 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB15484.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for METTL25 Gene

Post-translational modifications for METTL25 Gene

No Post-translational modifications

No data available for DME Specific Peptides for METTL25 Gene

Domains & Families for METTL25 Gene

Gene Families for METTL25 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for METTL25 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with METTL25: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for METTL25 Gene

Function for METTL25 Gene

Molecular function for METTL25 Gene

UniProtKB/Swiss-Prot Function:
Putative methyltransferase.

Enzyme Numbers (IUBMB) for METTL25 Gene

Gene Ontology (GO) - Molecular Function for METTL25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with METTL25: view

Phenotypes for METTL25 Gene

GenomeRNAi human phenotypes for METTL25:
genes like me logo Genes that share phenotypes with METTL25: view

Animal Model Products

miRNA for METTL25 Gene

miRTarBase miRNAs that target METTL25

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL25 Gene

Localization for METTL25 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL25 gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Mitochondria (1)
  • Plasma membrane (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for METTL25 Gene

Pathways & Interactions for METTL25 Gene

SuperPathways for METTL25 Gene

No Data Available

Interacting Proteins for METTL25 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000248306 Q8N6Q8-MET25_HUMAN for METTL25 Gene via STRING IID

Gene Ontology (GO) - Biological Process for METTL25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL25: view

No data available for Pathways by source and SIGNOR curated interactions for METTL25 Gene

Drugs & Compounds for METTL25 Gene

No Compound Related Data Available

Transcripts for METTL25 Gene

Unigene Clusters for METTL25 Gene

Methyltransferase like 25:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL25 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP2: - - - -
SP3: -
SP4: - - -
SP6: - -

Relevant External Links for METTL25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for METTL25 Gene

Protein differential expression in normal tissues from HIPED for METTL25 Gene

This gene is overexpressed in Bone marrow stromal cell (33.4) and Peripheral blood mononuclear cells (26.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for METTL25 Gene

Protein tissue co-expression partners for METTL25 Gene

NURSA nuclear receptor signaling pathways regulating expression of METTL25 Gene:


SOURCE GeneReport for Unigene cluster for METTL25 Gene:


Evidence on tissue expression from TISSUES for METTL25 Gene

  • Intestine(4.1)
genes like me logo Genes that share expression patterns with METTL25: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL25 Gene

Orthologs for METTL25 Gene

This gene was present in the common ancestor of animals.

Orthologs for METTL25 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia METTL25 33 34
  • 99.23 (n)
(Canis familiaris)
Mammalia METTL25 33
  • 88.1 (n)
C12ORF26 34
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 83 (a)
-- 34
  • 49 (a)
(Mus musculus)
Mammalia Mettl25 33 16 34
  • 80.8 (n)
(Rattus norvegicus)
Mammalia Mettl25 33
  • 79.53 (n)
(Bos Taurus)
Mammalia METTL25 33 34
  • 77.31 (n)
(Monodelphis domestica)
Mammalia METTL25 34
  • 63 (a)
(Gallus gallus)
Aves C1H12ORF26 33
  • 68.95 (n)
METTL25 34
  • 58 (a)
(Anolis carolinensis)
Reptilia METTL25 34
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl25 33
  • 60.83 (n)
Str.14343 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.13226 33
(Danio rerio)
Actinopterygii mettl25 33 34
  • 56.03 (n)
Dr.17382 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010960 33
  • 44.7 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG33964 33 34
  • 27.32 (n)
Species where no ortholog for METTL25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for METTL25 Gene

Gene Tree for METTL25 (if available)
Gene Tree for METTL25 (if available)

Paralogs for METTL25 Gene

Paralogs for METTL25 Gene

genes like me logo Genes that share paralogs with METTL25: view

Variants for METTL25 Gene

Sequence variations from dbSNP and Humsavar for METTL25 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs386352284 uncertain-significance, not provided 82,358,773(+) G/A 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs1000083930 -- 82,446,260(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000091090 -- 82,455,086(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000115993 -- 82,433,538(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000130534 -- 82,403,628(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for METTL25 Gene

Variant ID Type Subtype PubMed ID
esv2666887 CNV deletion 23128226
esv3303417 CNV mobile element insertion 20981092
esv3442704 CNV insertion 20981092
esv3549486 CNV deletion 23714750
esv3630157 CNV loss 21293372
esv3630158 CNV loss 21293372
nsv478456 CNV novel sequence insertion 20440878
nsv519197 CNV gain 19592680
nsv559539 CNV gain 21841781
nsv559541 CNV gain 21841781
nsv832471 CNV loss 17160897

Variation tolerance for METTL25 Gene

Residual Variation Intolerance Score: 36.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.61; 65.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for METTL25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL25 Gene

Disorders for METTL25 Gene

Additional Disease Information for METTL25

No disorders were found for METTL25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL25 Gene

Publications for METTL25 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for METTL25 Gene

Sources for METTL25 Gene

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