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Aliases for METTL24 Gene

Aliases for METTL24 Gene

  • Methyltransferase Like 24 2 3 5
  • C6orf186 3 4
  • Chromosome 6 Open Reading Frame 186 2
  • UPF0624 Protein C6orf186 3
  • EC 2.1.1.- 4
  • DJ71D21.2 3

External Ids for METTL24 Gene

Previous HGNC Symbols for METTL24 Gene

  • C6orf186

Previous GeneCards Identifiers for METTL24 Gene

  • GC06M110568

Summaries for METTL24 Gene

GeneCards Summary for METTL24 Gene

METTL24 (Methyltransferase Like 24) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL24 Gene

Genomics for METTL24 Gene

Regulatory Elements for METTL24 Gene

Promoters for METTL24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around METTL24 on UCSC Golden Path with GeneCards custom track

Genomic Location for METTL24 Gene

Chromosome:
6
Start:
110,245,928 bp from pter
End:
110,358,272 bp from pter
Size:
112,345 bases
Orientation:
Minus strand

Genomic View for METTL24 Gene

Genes around METTL24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL24 Gene

Proteins for METTL24 Gene

  • Protein details for METTL24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JXM2-MET24_HUMAN
    Recommended name:
    Methyltransferase-like protein 24
    Protein Accession:
    Q5JXM2
    Secondary Accessions:
    • Q6ZSU5

    Protein attributes for METTL24 Gene

    Size:
    366 amino acids
    Molecular mass:
    41330 Da
    Quaternary structure:
    No Data Available

neXtProt entry for METTL24 Gene

Proteomics data for METTL24 Gene at MOPED

Post-translational modifications for METTL24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for METTL24 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for METTL24 Gene

Domains & Families for METTL24 Gene

Gene Families for METTL24 Gene

Protein Domains for METTL24 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for METTL24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JXM2

UniProtKB/Swiss-Prot:

MET24_HUMAN :
  • Belongs to the methyltransferase superfamily.
Family:
  • Belongs to the methyltransferase superfamily.
genes like me logo Genes that share domains with METTL24: view

Function for METTL24 Gene

Enzyme Numbers (IUBMB) for METTL24 Gene

genes like me logo Genes that share phenotypes with METTL24: view

Animal Models for METTL24 Gene

MGI Knock Outs for METTL24:

Animal Model Products

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for METTL24 Gene

Localization for METTL24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL24 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for METTL24 Gene COMPARTMENTS Subcellular localization image for METTL24 gene
Compartment Confidence
extracellular 4
golgi apparatus 2
endoplasmic reticulum 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for METTL24 Gene

Pathways & Interactions for METTL24 Gene

SuperPathways for METTL24 Gene

No Data Available

Interacting Proteins for METTL24 Gene

Gene Ontology (GO) - Biological Process for METTL24 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for METTL24 Gene

Drugs & Compounds for METTL24 Gene

No Compound Related Data Available

Transcripts for METTL24 Gene

mRNA/cDNA for METTL24 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for METTL24 Gene

Methyltransferase like 24:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for METTL24 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: -
SP2: - - -
SP3: - -

Relevant External Links for METTL24 Gene

GeneLoc Exon Structure for
METTL24
ECgene alternative splicing isoforms for
METTL24

Expression for METTL24 Gene

mRNA expression in normal human tissues for METTL24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for METTL24 Gene

This gene is overexpressed in Pancreas (45.6) and Pancreatic juice (23.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for METTL24 Gene



SOURCE GeneReport for Unigene cluster for METTL24 Gene Hs.722171

genes like me logo Genes that share expression patterns with METTL24: view

Protein tissue co-expression partners for METTL24 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for METTL24 Gene

Orthologs for METTL24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for METTL24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL24 35
  • 98 (n)
  • 95.9 (a)
METTL24 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C9H6orf186 36
  • 87 (a)
OneToOne
C9H6orf186 35
  • 88.71 (n)
  • 87.43 (a)
dog
(Canis familiaris)
Mammalia METTL24 35
  • 90.53 (n)
  • 92.42 (a)
METTL24 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mettl24 16
Mettl24 36
  • 82 (a)
OneToOne
Mettl24 35
  • 80.94 (n)
  • 81.77 (a)
oppossum
(Monodelphis domestica)
Mammalia METTL24 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia METTL24 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mettl24 35
  • 81.68 (n)
  • 81.77 (a)
chicken
(Gallus gallus)
Aves C3H6ORF186 35
  • 73.23 (n)
  • 70.75 (a)
METTL24 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia METTL24 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl24 35
  • 62.69 (n)
  • 65.07 (a)
zebrafish
(Danio rerio)
Actinopterygii METTL24 36
  • 39 (a)
OneToOne
Species with no ortholog for METTL24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for METTL24 Gene

ENSEMBL:
Gene Tree for METTL24 (if available)
TreeFam:
Gene Tree for METTL24 (if available)

Paralogs for METTL24 Gene

No data available for Paralogs for METTL24 Gene

Variants for METTL24 Gene

Sequence variations from dbSNP and Humsavar for METTL24 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_044502 -
rs714693 -- 110,321,458(+) ATAGT(C/T)CTCAA intron-variant
rs761586 -- 110,332,497(-) ACTGT(A/G)TAGTT intron-variant
rs2073208 -- 110,315,662(-) AGTAA(C/T)TGAAA intron-variant
rs2073209 -- 110,315,654(-) AAATT(C/T)CTCCA intron-variant

Variation tolerance for METTL24 Gene

Residual Variation Intolerance Score: 70.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.83; 67.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for METTL24 Gene

HapMap Linkage Disequilibrium report
METTL24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for METTL24 Gene

Disorders for METTL24 Gene

Relevant External Links for METTL24

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
METTL24

No disorders were found for METTL24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL24 Gene

Publications for METTL24 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 67

Products for METTL24 Gene

Sources for METTL24 Gene

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