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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

METTL24 Gene

protein-coding   GIFtS: 33
GCID: GC06M110568          (predicted)

methyltransferase like 24

(Previous name: chromosome 6 open reading frame 186 )
(Previous symbol: C6orf186)
  Search for METTL24
in our new
 Human Malady Compendium 
Biological research products
for METTL24
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Methyltransferase Like 241 2     Methyltransferase-Like Protein 242
C6orf1861 2 3     UPF0624 Protein C6orf1862
DJ71D21.21     EC 2.1.1.-3
Chromosome 6 Open Reading Frame 1861     

External Ids:    HGNC: 215661   Entrez Gene: 7284642   Ensembl: ENSG000000533287   UniProtKB: Q5JXM23   

Export aliases for METTL24 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for METTL24
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for METTL24

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

METTL24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
METTL24 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M110568:  view genomic region     (about GC identifiers)

Start:
110,567,131 bp from pter      End:
110,679,475 bp from pter
Size:
112,345 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MET24_HUMAN, Q5JXM2 (See protein sequence)
Recommended Name: Methyltransferase-like protein 24 precursor  
Size: 366 amino acids; 41330 Da
Subcellular location: Secreted (Potential)
Secondary accessions: Q6ZSU5

Explore the universe of human proteins at neXtProt for METTL24: NX_Q5JXM2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5JXM2

  • METTL24 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001116836.1  
    ENSEMBL proteins: 
     ENSP00000344071  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--


    METTL24 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    METTL24 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026913 METTL24

    Graphical View of Domain Structure for InterPro Entry Q5JXM2

    ProtoNet protein and cluster: Q5JXM2

    UniProtKB/Swiss-Prot: MET24_HUMAN, Q5JXM2
    Similarity: Belongs to the methyltransferase superfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Enzyme Number (IUBMB): EC 2.1.1.-1

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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008168methyltransferase activity IEA--


    METTL24 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for METTL24:
     G0/1 arrest  Increased G1 DNA content  Increased cell size 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for METTL24

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for METTL24
    Search CenterWatch for drugs/clinical trials and news about METTL24 / MET24 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for METTL24 gene: 
    NM_001123364.1  

    Unigene Cluster for METTL24:

    Methyltransferase like 24
    Hs.722171  [show with all ESTs]
    Unigene Representative Sequence: NM_001123364
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338882(uc010kdu.1 uc003pub.2) ENST00000490043

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    2 DOTS entries:

    DT.100641847  DT.121322773 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for METTL24    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
    SP1:              -                                             
    SP2:                          -     -     -                     
    SP3:              -           -                                 


    ECgene alternative splicing isoforms for METTL24

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    METTL24 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    METTL24 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See METTL24 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.722171
        SABiosciences Custom PCR Arrays for METTL24
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL24

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for METTL24 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mettl241 , 5 RIKEN cDNA 9030224M15 gene5
    methyltransferase like 241
    81.49(n)1
    82.87(a)1
      10 (22.02 cM)5
    3277471  NM_177793.31  NP_808461.11 
     406832825 
    chicken
    (Gallus gallus)
    Aves C3H6orf1861 chromosome 3 open reading frame, human C6orf186 70.51(n)
    66.43(a)
      421758  XM_419788.2  XP_419788.2 
    lizard
    (Anolis carolinensis)
    Reptilia C6orf1866
    --
    74(a)
    1 ↔ 1
    1(191619653-191680842)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-158b22.1-26
    si:ch211-158b22.1-2
    37(a)
    1 ↔ 1
    20(53758199-53785287)


    ENSEMBL Gene Tree for METTL24 (if available)
    TreeFam Gene Tree for METTL24 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1978 NCBI SNPs in METTL24 are shown (see all 1978    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1390632411,2
    --110566701(+) TATCAC/TTAACA 1 -- ds50010--------
    rs1853487201,2
    --110566732(+) GAAAAA/TGGAGG 1 -- ds50010--------
    rs559279201,2
    C,F,--110566745(+) CAAATT/CCAAAT 1 -- ds50013Minor allele frequency- C:0.08WA NA EA 358
    rs1174493141,2
    F,--110566772(+) AACAGT/CAGGGG 1 -- ds50011Minor allele frequency- C:0.02NA 120
    rs77565511,2
    C,H,--110566775(+) AGTAGG/CGGAAG 1 -- ds5001 ese3 trp34Minor allele frequency- C:0.00NS EA 416
    rs561120561,2
    C,F,--110566896(+) ATGAGC/TTGGGG 1 -- ds50015Minor allele frequency- T:0.19WA CSA NA EA 362
    rs737656851,2
    C,F,--110566937(+) TCTGGG/ACAAAT 1 -- ds50014Minor allele frequency- A:0.15WA CSA NA 242
    rs2000636821,2
    --110567114(+) CTGCAA/TATATT 1 -- ds50010--------
    rs2000828061,2
    C--110567212(+) TCTTTC/TTTCAA 2 K syn11Minor allele frequency- T:0.00EU 1323
    rs1459798651,2
    C,--110567306(+) AGAACC/TGCACA 2 Q R mis10--------

    HapMap Linkage Disequilibrium report for METTL24 (110567131 - 110679475 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for METTL24: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for METTL24 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with METTL24)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    2. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 728464 HGNC: 21566 Ensembl:ENSG00000053328 euGenes: HUgn728464 ECgene: METTL24
    H-InvDB: METTL24

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for METTL24 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for METTL24 gene:
    Search GeneIP for patents involving METTL24

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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    About This Section

     
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     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL24
     Browse SwitchGear 3'UTR luciferase reporter plasmids for METTL24
     Browse SwitchGear Promoter luciferase reporter plasmids for METTL24
     Search ThermoFisher Antibodies for METTL24
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat METTL24
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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