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Aliases for METTL24 Gene

Aliases for METTL24 Gene

  • Methyltransferase Like 24 2 3 5
  • C6orf186 3 4
  • Chromosome 6 Open Reading Frame 186 2
  • Methyltransferase-Like Protein 24 3
  • UPF0624 Protein C6orf186 3
  • EC 2.1.1.- 4
  • DJ71D21.2 3

External Ids for METTL24 Gene

Previous HGNC Symbols for METTL24 Gene

  • C6orf186

Previous GeneCards Identifiers for METTL24 Gene

  • GC06M110568

Summaries for METTL24 Gene

GeneCards Summary for METTL24 Gene

METTL24 (Methyltransferase Like 24) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL24 Gene

Genomics for METTL24 Gene

Regulatory Elements for METTL24 Gene

Enhancers for METTL24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G109453 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.9 +901.1 901113 7.8 HDGF PKNOX1 AGO1 WRNIP1 ARID4B SIN3A ZBTB7B ZNF143 KLF13 SP3 SMPD2 ZBTB24 MICAL1 ENSG00000260273 METTL24 LOC105377935 FIG4 PPIL6 CD164 PIR52480
GH06G110636 1.2 dbSUPER 13 -278.8 -278832 1.3 HNRNPUL1 HDGF CREB3L1 MLX AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 MFSD4B ENSG00000220506 METTL24 BRD7P4 FCF1P5 ENSG00000272356 LOC100129155 LOC100420531
GH06G110957 1.2 ENCODE 12.9 -600.5 -600473 1.9 MLX CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF610 METTL24 RPF2 SLC16A10 GTF3C6
GH06G110331 0.9 dbSUPER 12.4 +26.0 25953 1.3 ELF3 PKNOX1 FOXA2 ATF1 MLX SIN3A BMI1 RARA CREM THAP11 METTL24 LOC102724586 GC06M110279
GH06G110333 0.6 dbSUPER 12.9 +23.5 23476 1.8 SOX5 SOX13 FOXA2 ZNF394 FOXA1 GATA3 FOS FOXP1 METTL24 WASF1 SLC22A16 LOC102724586 GC06M110279
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around METTL24 on UCSC Golden Path with GeneCards custom track

Promoters for METTL24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000201042 172 601 FOXM1 ZNF202 CTCF PKNOX1 ARNT SUZ12 EZH2

Genomic Location for METTL24 Gene

Chromosome:
6
Start:
110,245,928 bp from pter
End:
110,358,272 bp from pter
Size:
112,345 bases
Orientation:
Minus strand

Genomic View for METTL24 Gene

Genes around METTL24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL24 Gene

Proteins for METTL24 Gene

  • Protein details for METTL24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JXM2-MET24_HUMAN
    Recommended name:
    Methyltransferase-like protein 24
    Protein Accession:
    Q5JXM2
    Secondary Accessions:
    • Q6ZSU5

    Protein attributes for METTL24 Gene

    Size:
    366 amino acids
    Molecular mass:
    41330 Da
    Quaternary structure:
    No Data Available

neXtProt entry for METTL24 Gene

Post-translational modifications for METTL24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for METTL24 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for METTL24 Gene

Domains & Families for METTL24 Gene

Protein Domains for METTL24 Gene

Suggested Antigen Peptide Sequences for METTL24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JXM2

UniProtKB/Swiss-Prot:

MET24_HUMAN :
  • Belongs to the methyltransferase superfamily.
Family:
  • Belongs to the methyltransferase superfamily.
genes like me logo Genes that share domains with METTL24: view

No data available for Gene Families for METTL24 Gene

Function for METTL24 Gene

Enzyme Numbers (IUBMB) for METTL24 Gene

Gene Ontology (GO) - Molecular Function for METTL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with METTL24: view
genes like me logo Genes that share phenotypes with METTL24: view

Animal Models for METTL24 Gene

MGI Knock Outs for METTL24:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for METTL24 Gene

Localization for METTL24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL24 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL24 gene
Compartment Confidence
extracellular 4
golgi apparatus 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for METTL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with METTL24: view

Pathways & Interactions for METTL24 Gene

SuperPathways for METTL24 Gene

No Data Available

Interacting Proteins for METTL24 Gene

Gene Ontology (GO) - Biological Process for METTL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL24: view

No data available for Pathways by source and SIGNOR curated interactions for METTL24 Gene

Drugs & Compounds for METTL24 Gene

No Compound Related Data Available

Transcripts for METTL24 Gene

mRNA/cDNA for METTL24 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for METTL24 Gene

Methyltransferase like 24:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL24 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: -
SP2: - - -
SP3: - -

Relevant External Links for METTL24 Gene

GeneLoc Exon Structure for
METTL24
ECgene alternative splicing isoforms for
METTL24

Expression for METTL24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for METTL24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for METTL24 Gene

This gene is overexpressed in Pancreas (45.6) and Pancreatic juice (23.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for METTL24 Gene



Protein tissue co-expression partners for METTL24 Gene

NURSA nuclear receptor signaling pathways regulating expression of METTL24 Gene:

METTL24

SOURCE GeneReport for Unigene cluster for METTL24 Gene:

Hs.722171

Evidence on tissue expression from TISSUES for METTL24 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with METTL24: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL24 Gene

Orthologs for METTL24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for METTL24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL24 34 35
  • 98 (n)
dog
(Canis familiaris)
Mammalia METTL24 34 35
  • 90.53 (n)
cow
(Bos Taurus)
Mammalia C9H6orf186 34 35
  • 88.71 (n)
rat
(Rattus norvegicus)
Mammalia Mettl24 34
  • 81.68 (n)
mouse
(Mus musculus)
Mammalia Mettl24 34 16 35
  • 80.94 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia METTL24 35
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia METTL24 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves C3H6ORF186 34
  • 73.23 (n)
METTL24 35
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia METTL24 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl24 34
  • 62.69 (n)
zebrafish
(Danio rerio)
Actinopterygii METTL24 35
  • 39 (a)
OneToOne
Species where no ortholog for METTL24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for METTL24 Gene

ENSEMBL:
Gene Tree for METTL24 (if available)
TreeFam:
Gene Tree for METTL24 (if available)

Paralogs for METTL24 Gene

No data available for Paralogs for METTL24 Gene

Variants for METTL24 Gene

Sequence variations from dbSNP and Humsavar for METTL24 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000025499 -- 110,288,246(+) CACAC(A/C)TTGTT intron-variant
rs1000058780 -- 110,292,889(+) GCCTT(C/T)ATCAT intron-variant
rs1000195755 -- 110,281,564(+) GTAGA(A/G)GTTGA intron-variant
rs1000208010 -- 110,296,332(+) AACTG(-/T)ATGCT intron-variant
rs1000213348 -- 110,326,291(+) ATCAG(A/G)CCCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for METTL24 Gene

Variant ID Type Subtype PubMed ID
dgv10908n54 CNV loss 21841781
dgv10909n54 CNV loss 21841781
dgv10910n54 CNV loss 21841781
dgv10911n54 CNV loss 21841781
dgv1210e214 CNV loss 21293372
esv2162143 CNV deletion 18987734
esv25776 CNV loss 19812545
esv2658858 CNV deletion 23128226
esv2671329 CNV deletion 23128226
esv2732568 CNV deletion 23290073
esv2732569 CNV deletion 23290073
esv3361193 CNV duplication 20981092
esv3540306 CNV deletion 23714750
esv3540307 CNV deletion 23714750
esv3571359 CNV loss 25503493
esv3610352 CNV loss 21293372
esv3610353 CNV loss 21293372
esv3610355 CNV loss 21293372
esv3610357 CNV gain 21293372
nsv5439 CNV insertion 18451855
nsv604511 CNV loss 21841781
nsv604516 CNV loss 21841781

Variation tolerance for METTL24 Gene

Residual Variation Intolerance Score: 70.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.83; 67.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for METTL24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
METTL24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL24 Gene

Disorders for METTL24 Gene

Relevant External Links for METTL24

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
METTL24

No disorders were found for METTL24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL24 Gene

Publications for METTL24 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 4 64

Products for METTL24 Gene

Sources for METTL24 Gene

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