METTL23 Gene
protein-coding GIFtS: 39
GCID: GC17P074723
|
|
methyltransferase like 23(Previous name: chromosome 17 open reading frame 95 )
(Previous symbol: C17orf95)
| |
Aliases
for METTL23 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Methyltransferase Like 231 2 | | C17orf951 2 3 | | LOC1245121 | | Chromosome 17 Open Reading Frame 951 | | Methyltransferase-Like Protein 232 | | EC 2.1.1.-3 |
| External Ids: | HGNC: 269881 | Entrez Gene: 1245122 | Ensembl: ENSG000001810387 | UniProtKB: Q86XA03 | | ORGUL members: | |
|---|
| NONCODE:n410744 | |
Export aliases for METTL23 gene to outside databases
|---|
Summaries
for METTL23 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MET23_HUMAN, Q86XA0Function: Probable methyltransferase (By similarity)
|
Genomic Views
for METTL23 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for METTL23
Other transcription factors
Search SABiosciences Chromatin IP Primers for METTL23
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL23 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25.1 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q25.2METTL23 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P074723: view genomic region
(about GC identifiers)
Start:
|
74,722,912 bp from pter |
End:
|
74,730,018 bp from pter |
Size:
|
7,107 bases |
Orientation:
|
plus strand |
|
Proteins
for METTL23 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MET23_HUMAN, Q86XA0 (See
protein sequence)Recommended Name: Methyltransferase-like protein 23 Size: 190 amino acids; 21469 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=AAH45819.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;Explore the universe of human proteins at neXtProt for METTL23: NX_Q86XA0
METTL23 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (6 alternative transcripts):
NP_001073979.3 NP_001193912.1 NP_001193913.1 NP_001193914.1 NP_001193915.1 NP_001193916.1
ENSEMBL proteins: ENSP00000464965 ENSP00000466614 ENSP00000467527 ENSP00000468386 ENSP00000466938 ENSP00000467503 ENSP00000466203 ENSP00000468704 ENSP00000465890 ENSP00000341543 ENSP00000465430 ENSP00000465959 ENSP00000467101
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
METTL23 for ontologies About GeneDecksing
METTL23 Antibody Products:
Assay Products for METTL23: |
Protein
Domains /
Families
for METTL23 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
METTL23 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q86XA0ProtoNet protein and cluster: Q86XA0 UniProtKB/Swiss-Prot: MET23_HUMAN, Q86XA0Similarity: Belongs to the methyltransferase superfamily. METTL23 family |
Function
for METTL23 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MET23_HUMAN, Q86XA0Function: Probable methyltransferase (By similarity)Enzyme Number (IUBMB): EC 2.1.1.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL23 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL23
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: METTL23 (NM_001080510) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for METTL23 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat METTL23 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL23 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008168 | methyltransferase activity |
IEA | -- |
METTL23 for ontologies About GeneDecksing
|
Pathways & Interactions
for METTL23 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for METTL23
2 Interacting proteins for METTL23 (Q86XA02, 3) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for METTL23 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for METTL23
Search CenterWatch for drugs/clinical trials and news about METTL23 / MET23
|
Transcripts
for METTL23 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for METTL23 gene (6 alternative transcripts): NM_001080510.3 NM_001206983.1 NM_001206984.1 NM_001206985.1 NM_001206986.1 NM_001206987.1 Unigene Cluster for METTL23: Methyltransferase like 23 Hs.74655 [show with all ESTs]Unigene Representative Sequence: BM91576014 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000589977 ENST00000591571 ENST00000592849 ENST00000586738 ENST00000588783
ENST00000588563 ENST00000586752 ENST00000588302 ENST00000590964 ENST00000341249(uc021udk.1 uc002jsr.3 uc021udl.1 uc021udm.1 uc002jst.3 uc021udn.1 uc002jsu.3)
ENST00000588822 ENST00000586200 ENST00000589581 ENST00000588964
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL23 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL23
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: METTL23 (NM_001080510) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for METTL23 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat METTL23 |
Additional cDNA sequence: BC033998.2 BC045819.1 BC106939.2 JQ313903.1 NR_038193.1 22 DOTS entries: DT.97845886 DT.91890924 DT.120924856 DT.451816 DT.120925048 DT.100818660 DT.91750300 DT.100818661 DT.100818666 DT.117441 DT.100818653 DT.120924815 DT.100818655 DT.100818658 DT.100818665 DT.120925059 DT.91750309 DT.95125250 DT.100818663 DT.120924831 DT.120924811 DT.92463582 24/181 AceView cDNA sequences (see all 181): H80068 CF127707 AW169054 BM672232 CR602837 AA804670 BU632694 AI926677 BM847256 BQ574336 CR593227 AI357221 AA862641 AA318706 AW272447 CA444656 AA905849 CR597996 AA446970 BQ772021 BM762373 AI215960 AA970390 AI243833
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for METTL23 (see all 13) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | · | 2f | · | 2g | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | |
| ExUns: | 6f | · | 6g | · | 6h |
|---|
|
| SP1: | | | | | | | |
| SP2: | | | | | | | |
| SP3: | | | | | | | |
| SP4: | | | | | | | |
| SP5: | | | | | | |
ECgene alternative splicing isoforms for METTL23
|
Expression
for METTL23 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| METTL23 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGTCATATA
About this image
See METTL23 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for METTL23
SOURCE GeneReport for Unigene cluster: Hs.74655
SABiosciences Custom PCR Arrays for METTL23
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for METTL23
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat METTL23 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL23 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL23 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL23 |
Orthologs
for METTL23 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for METTL23 gene from 6/22 species (see all 22) About this table
ENSEMBL Gene Tree for METTL23 (if available)
TreeFam Gene Tree for METTL23 (if available) |
Paralogs
for METTL23 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for METTL23 gene
- ENSG000002671682
1 SIMAP similar gene for METTL23 using alignment to 11 protein entries: MET23_HUMAN (see all proteins):C17orf95
METTL23 for paralogs About GeneDecksing
|
Genomic Variants
for METTL23 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for METTL23 (74722912 - 74730018 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for METTL23: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing METTL23 |
|
Disorders
/ Diseases
for METTL23 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for METTL23 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for METTL23 gene integrated from 9 sources:
(articles sorted by number of sources associating them with METTL23) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
|
External Searches for METTL23 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing METTL23 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing METTL23 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing METTL23 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for METTL23 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for METTL23 gene:
Search GeneIP for patents involving METTL23
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for METTL23 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for METTL23 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for METTL23 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for METTL23 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for METTL23 | | OriGene 3'-UTR Clone for METTL23 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL23 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL23 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for METTL23 | | OriGene Custom Protein Services for METTL23 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat METTL23 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing METTL23 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL23 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat METTL23 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL23 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL23 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for METTL23 |
| |  |  |  |  | | | | |
 |
 |
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 | | | METTL23 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL23 |
|  |  |  | | | | Search ThermoFisher Antibodies for METTL23 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat METTL23 |
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