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Aliases for METTL22 Gene

Aliases for METTL22 Gene

  • Methyltransferase Like 22 2 3 5
  • C16orf68 3 4
  • Chromosome 16 Open Reading Frame 68 2
  • Methyltransferase-Like Protein 22 3
  • EC 2.1.1.- 4
  • LP8272 3

External Ids for METTL22 Gene

Previous HGNC Symbols for METTL22 Gene

  • C16orf68

Previous GeneCards Identifiers for METTL22 Gene

  • GC16P008717

Summaries for METTL22 Gene

Entrez Gene Summary for METTL22 Gene

  • This gene encodes a member of the non-histone lysine methyltransferases. It interacts with its substrate, Kin17, which is involved in DNA repair and replication and mRNA processing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for METTL22 Gene

METTL22 (Methyltransferase Like 22) is a Protein Coding gene. Among its related pathways are Protein methylation and Metabolism of proteins. GO annotations related to this gene include methyltransferase activity.

UniProtKB/Swiss-Prot for METTL22 Gene

  • Protein N-lysine methyltransferase. In vitro methylates KIN.

Additional gene information for METTL22 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL22 Gene

Genomics for METTL22 Gene

Regulatory Elements for METTL22 Gene

Enhancers for METTL22 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H009089 1.4 ENCODE dbSUPER 23.7 +470.5 470460 4 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 ZNF143 USP7 METTL22 LINC01195 LINC01177 ENSG00000260003 ENSG00000260058 ENSG00000263244 CARHSP1 ENSG00000260349 PIR39735
GH16H008621 1.3 ENCODE dbSUPER 24.1 +0.5 521 2 ATF1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 GTF3C2 SP3 SP5 METTL22 USP7 ENSG00000260349 PMM2 GC16M008655
GH16H008631 1.5 FANTOM5 Ensembl ENCODE dbSUPER 15.5 +11.1 11121 2 TCF12 CTCF FOS HOMEZ GABPA C16orf72 METTL22 TMEM114 USP7 GC16M008655
GH16H009138 1.1 Ensembl ENCODE 16.5 +517.6 517585 0 ELF3 HDGF RB1 ZNF2 RAD21 HSF1 ZNF143 RUNX3 CREM THAP11 METTL22 C16orf72 GC16P009141 PIR60317
GH16H008644 1 Ensembl ENCODE dbSUPER 17.1 +23.3 23261 1 CTCF POLR2A MAX MYC GABPA METTL22 GC16M008655
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around METTL22 on UCSC Golden Path with GeneCards custom track

Promoters for METTL22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082976 361 1600 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 GTF3C2 SP3 SP5 YY2

Genomic Location for METTL22 Gene

Chromosome:
16
Start:
8,621,640 bp from pter
End:
8,661,208 bp from pter
Size:
39,569 bases
Orientation:
Plus strand

Genomic View for METTL22 Gene

Genes around METTL22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL22 Gene

Proteins for METTL22 Gene

  • Protein details for METTL22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUU2-MET22_HUMAN
    Recommended name:
    Methyltransferase-like protein 22
    Protein Accession:
    Q9BUU2
    Secondary Accessions:
    • B2RD29
    • D3DUF2
    • Q6XYB4
    • Q9HA03

    Protein attributes for METTL22 Gene

    Size:
    404 amino acids
    Molecular mass:
    44486 Da
    Quaternary structure:
    • Interacts with members of the heat shock protein 90 and 70 families; these proteins probably are methylation substrates.

    Alternative splice isoforms for METTL22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for METTL22 Gene

Post-translational modifications for METTL22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for METTL22 Gene

Domains & Families for METTL22 Gene

Gene Families for METTL22 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for METTL22 Gene

Suggested Antigen Peptide Sequences for METTL22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BUU2

UniProtKB/Swiss-Prot:

MET22_HUMAN :
  • Belongs to the methyltransferase superfamily. METTL22 family.
Family:
  • Belongs to the methyltransferase superfamily. METTL22 family.
genes like me logo Genes that share domains with METTL22: view

Function for METTL22 Gene

Molecular function for METTL22 Gene

UniProtKB/Swiss-Prot Function:
Protein N-lysine methyltransferase. In vitro methylates KIN.

Enzyme Numbers (IUBMB) for METTL22 Gene

Gene Ontology (GO) - Molecular Function for METTL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23349634
GO:0008168 methyltransferase activity IEA --
GO:0008276 protein methyltransferase activity IDA 23349634
GO:0016279 protein-lysine N-methyltransferase activity TAS --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with METTL22: view
genes like me logo Genes that share phenotypes with METTL22: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for METTL22
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL22 Gene

Localization for METTL22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL22 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL22 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for METTL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 23349634
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0043234 protein complex IDA 23349634
genes like me logo Genes that share ontologies with METTL22: view

Pathways & Interactions for METTL22 Gene

genes like me logo Genes that share pathways with METTL22: view

Pathways by source for METTL22 Gene

Gene Ontology (GO) - Biological Process for METTL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006479 protein methylation IDA,TAS --
GO:0018022 peptidyl-lysine methylation IEA --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL22: view

No data available for SIGNOR curated interactions for METTL22 Gene

Drugs & Compounds for METTL22 Gene

No Compound Related Data Available

Transcripts for METTL22 Gene

Unigene Clusters for METTL22 Gene

Methyltransferase like 22:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for METTL22
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for METTL22 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13 ^
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - -
SP4: - -
SP5: - - -
SP6: - - - -
SP7:
SP8:
SP9: - -
SP10: - - - - - -
SP11: -
SP12: - -
SP13: - - - - - - - - - - -
SP14: - - -
SP15:
SP16:
SP17:

ExUns: 14 ^ 15a · 15b ^ 16a · 16b · 16c · 16d ^ 17a · 17b · 17c ^ 18
SP1: - - - -
SP2: - -
SP3: - -
SP4: - - -
SP5: - -
SP6:
SP7:
SP8: - - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for METTL22 Gene

GeneLoc Exon Structure for
METTL22
ECgene alternative splicing isoforms for
METTL22

Expression for METTL22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for METTL22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for METTL22 Gene

This gene is overexpressed in Muscle - Skeletal (x4.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for METTL22 Gene



NURSA nuclear receptor signaling pathways regulating expression of METTL22 Gene:

METTL22

SOURCE GeneReport for Unigene cluster for METTL22 Gene:

Hs.306380

Evidence on tissue expression from TISSUES for METTL22 Gene

  • Nervous system(4.2)
  • Liver(4.1)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with METTL22: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL22 Gene

Orthologs for METTL22 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METTL22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL22 33 34
  • 98.68 (n)
rat
(Rattus norvegicus)
Mammalia Mettl22 33
  • 82.43 (n)
dog
(Canis familiaris)
Mammalia METTL22 33 34
  • 82.29 (n)
mouse
(Mus musculus)
Mammalia Mettl22 33 16 34
  • 82.26 (n)
cow
(Bos Taurus)
Mammalia METTL22 33 34
  • 81.02 (n)
oppossum
(Monodelphis domestica)
Mammalia METTL22 34
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia METTL22 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves METTL22 33 34
  • 61.98 (n)
lizard
(Anolis carolinensis)
Reptilia METTL22 34
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl22 33
  • 56.89 (n)
zebrafish
(Danio rerio)
Actinopterygii mettl22 33 34
  • 62.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10584 33 34
  • 47.08 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011879 33
  • 45.32 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G79915 33
  • 47.16 (n)
rice
(Oryza sativa)
Liliopsida Os06g0639300 33
  • 47.13 (n)
Species where no ortholog for METTL22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for METTL22 Gene

ENSEMBL:
Gene Tree for METTL22 (if available)
TreeFam:
Gene Tree for METTL22 (if available)

Paralogs for METTL22 Gene

No data available for Paralogs for METTL22 Gene

Variants for METTL22 Gene

Sequence variations from dbSNP and Humsavar for METTL22 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000042125 -- 8,667,214(+) TTTTC(-/TT)TTTTA intron-variant
rs1000081042 -- 8,634,373(+) TTAAC(A/G)ACAAA intron-variant
rs1000167666 -- 8,643,763(+) CATGC(C/G)TCACC intron-variant
rs1000186166 -- 8,673,290(+) GCTGG(A/T)CTCGA intron-variant, upstream-variant-2KB
rs1000240052 -- 8,621,154(+) GAGAC(C/T)AGCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for METTL22 Gene

Variant ID Type Subtype PubMed ID
esv1261959 CNV insertion 17803354
esv1322482 CNV insertion 17803354
esv2762154 CNV gain 21179565
esv3416142 CNV insertion 20981092
esv3441939 CNV insertion 20981092
esv3570276 CNV gain 25503493
esv3582003 CNV loss 25503493
esv3892786 CNV loss 25118596
nsv1037325 CNV gain 25217958
nsv1047172 CNV gain 25217958
nsv1144754 CNV deletion 24896259
nsv571406 CNV gain 21841781
nsv827546 CNV gain 20364138

Variation tolerance for METTL22 Gene

Residual Variation Intolerance Score: 90.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.15; 80.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for METTL22 Gene

Human Gene Mutation Database (HGMD)
METTL22
SNPedia medical, phenotypic, and genealogical associations of SNPs for
METTL22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL22 Gene

Disorders for METTL22 Gene

Relevant External Links for METTL22

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
METTL22

No disorders were found for METTL22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL22 Gene

Publications for METTL22 Gene

  1. Methylation of the DNA/RNA-binding protein Kin17 by METTL22 affects its association with chromatin. (PMID: 24140279) Cloutier P … Coulombe B (Journal of proteomics 2014) 2 3 60
  2. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P … Coulombe B (PLoS genetics 2013) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 60

Products for METTL22 Gene

Sources for METTL22 Gene

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