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Aliases for METTL22 Gene

Aliases for METTL22 Gene

  • Methyltransferase Like 22 2 3
  • C16orf68 3 4 6
  • Chromosome 16 Open Reading Frame 68 2
  • Methyltransferase-Like Protein 22 3
  • EC 2.1.1.- 4
  • LP8272 3

External Ids for METTL22 Gene

Previous HGNC Symbols for METTL22 Gene

  • C16orf68

Previous GeneCards Identifiers for METTL22 Gene

  • GC16P008717

Summaries for METTL22 Gene

GeneCards Summary for METTL22 Gene

METTL22 (Methyltransferase Like 22) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity.

UniProtKB/Swiss-Prot for METTL22 Gene

  • Protein N-lysine methyltransferase. In vitro methylates KIN.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL22 Gene

Genomics for METTL22 Gene

Genomic Location for METTL22 Gene

Start:
8,621,640 bp from pter
End:
8,649,654 bp from pter
Size:
28,015 bases
Orientation:
Plus strand

Genomic View for METTL22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for METTL22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL22 Gene

No data available for Regulatory Elements for METTL22 Gene

Proteins for METTL22 Gene

  • Protein details for METTL22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUU2-MET22_HUMAN
    Recommended name:
    Methyltransferase-like protein 22
    Protein Accession:
    Q9BUU2
    Secondary Accessions:
    • B2RD29
    • D3DUF2
    • Q6XYB4
    • Q9HA03

    Protein attributes for METTL22 Gene

    Size:
    404 amino acids
    Molecular mass:
    44486 Da
    Quaternary structure:
    • Interacts with members of the heat shock protein 90 and 70 families; these proteins probably are methylation substrates.

    Alternative splice isoforms for METTL22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for METTL22 Gene

Proteomics data for METTL22 Gene at MOPED

Post-translational modifications for METTL22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for METTL22 Gene

Domains for METTL22 Gene

Protein Domains for METTL22 Gene

Suggested Antigen Peptide Sequences for METTL22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BUU2

UniProtKB/Swiss-Prot:

MET22_HUMAN :
  • Q9BUU2
Family:
  • Belongs to the methyltransferase superfamily. METTL22 family.
genes like me logo Genes that share domains with METTL22: view

No data available for Gene Families for METTL22 Gene

Function for METTL22 Gene

Molecular function for METTL22 Gene

UniProtKB/Swiss-Prot Function: Protein N-lysine methyltransferase. In vitro methylates KIN.

Enzyme Numbers (IUBMB) for METTL22 Gene

Gene Ontology (GO) - Molecular Function for METTL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with METTL22: view

Phenotypes for METTL22 Gene

GenomeRNAi human phenotypes for METTL22:
genes like me logo Genes that share phenotypes with METTL22: view

Animal Model Products

CRISPR Products

miRNA for METTL22 Gene

miRTarBase miRNAs that target METTL22

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for METTL22

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for METTL22 Gene

Localization for METTL22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL22 Gene

Gene Ontology (GO) - Cellular Components for METTL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with METTL22: view

No data available for Subcellular locations from COMPARTMENTS for METTL22 Gene

Pathways for METTL22 Gene

SuperPathways for METTL22 Gene

No Data Available

Interacting Proteins for METTL22 Gene

Gene Ontology (GO) - Biological Process for METTL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL22: view

No data available for Pathways by source for METTL22 Gene

Transcripts for METTL22 Gene

Unigene Clusters for METTL22 Gene

Methyltransferase like 22:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for METTL22

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for METTL22

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL22 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13 ^
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - -
SP4: - -
SP5: - - -
SP6: - - - -
SP7:
SP8:
SP9: - -
SP10: - - - - - -
SP11: -
SP12: - -
SP13: - - - - - - - - - - -
SP14: - - -
SP15:
SP16:
SP17:

ExUns: 14 ^ 15a · 15b ^ 16a · 16b · 16c · 16d ^ 17a · 17b · 17c ^ 18
SP1: - - - -
SP2: - -
SP3: - -
SP4: - - -
SP5: - -
SP6:
SP7:
SP8: - - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for METTL22 Gene

GeneLoc Exon Structure for
METTL22
ECgene alternative splicing isoforms for
METTL22

Expression for METTL22 Gene

mRNA expression in normal human tissues for METTL22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for METTL22 Gene

This gene is overexpressed in Muscle - Skeletal (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for METTL22 Gene

SOURCE GeneReport for Unigene cluster for METTL22 Gene Hs.306380

genes like me logo Genes that share expressions with METTL22: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for METTL22 Gene

Orthologs for METTL22 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METTL22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL22 35
  • 98.68 (n)
  • 99.01 (a)
METTL22 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia METTL22 35
  • 81.02 (n)
  • 80.53 (a)
METTL22 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia METTL22 35
  • 82.29 (n)
  • 81.25 (a)
METTL22 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mettl22 35
  • 82.26 (n)
  • 80.88 (a)
Mettl22 16
Mettl22 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia METTL22 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia METTL22 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mettl22 35
  • 82.43 (n)
  • 80.88 (a)
chicken
(Gallus gallus)
Aves METTL22 35
  • 61.98 (n)
  • 59.64 (a)
METTL22 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia METTL22 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl22 35
  • 56.89 (n)
  • 53.07 (a)
zebrafish
(Danio rerio)
Actinopterygii mettl22 35
  • 62.98 (n)
  • 59.59 (a)
mettl22 36
  • 57 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011879 35
  • 45.32 (n)
  • 32.81 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10584 35
  • 47.08 (n)
  • 40.28 (a)
CG10584 36
  • 36 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G79915 35
  • 47.16 (n)
  • 36.24 (a)
rice
(Oryza sativa)
Liliopsida Os06g0639300 35
  • 47.13 (n)
  • 38.83 (a)
Species with no ortholog for METTL22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for METTL22 Gene

ENSEMBL:
Gene Tree for METTL22 (if available)
TreeFam:
Gene Tree for METTL22 (if available)

Paralogs for METTL22 Gene

No data available for Paralogs for METTL22 Gene

Variants for METTL22 Gene

Sequence variations from dbSNP and Humsavar for METTL22 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1060541 -- 8,646,120(+) GGAAG(A/G)TCATC reference, missense, downstream-variant-500B, synonymous-codon, nc-transcript-variant
rs1362340 -- 8,629,900(+) GCACA(A/G)CCCCT intron-variant
rs1362341 -- 8,629,920(+) GTGCA(C/T)GGATG intron-variant
rs1362342 -- 8,638,705(+) TCTCA(A/G)TAGCT intron-variant
rs1362343 -- 8,638,813(+) ACGCG(G/T)GTTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for METTL22 Gene

Variant ID Type Subtype PubMed ID
nsv905305 CNV Loss 21882294
nsv827546 CNV Gain 20364138
esv1261959 CNV Insertion 17803354
esv1322482 CNV Insertion 17803354

Relevant External Links for METTL22 Gene

HapMap Linkage Disequilibrium report
METTL22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL22 Gene

Disorders for METTL22 Gene

No disorders were found for METTL22 Gene.

No data available for UniProtKB/Swiss-Prot for METTL22 Gene

Publications for METTL22 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P. … Coulombe B. (PLoS Genet. 2013) 3 4
  3. Methylation of the DNA/RNA-binding protein Kin17 by METTL22 affects its association with chromatin. (PMID: 24140279) Cloutier P. … Coulombe B. (J Proteomics 2014) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 4

Products for METTL22 Gene

Sources for METTL22 Gene

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