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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

METTL22 Gene

protein-coding GIFtS: 41
GCID: GC16P008717

methyltransferase like 22

(Previous name: chromosome 16 open reading frame 68 )
(Previous symbol: C16orf68)

Search for METTL22
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Methyltransferase Like 22¹ ²		Chromosome 16 Open Reading Frame 68¹
C16orf68¹ ² ³		LP8272²
FLJ12433¹		Methyltransferase-Like Protein 22²
MGC2654¹		EC 2.1.1.-³

External Ids:	HGNC: 28368¹	Entrez Gene: 79091²	Ensembl: ENSG00000067365⁷	UniProtKB: Q9BUU2³

Export aliases for METTL22 gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MET22_HUMAN, Q9BUU2

Function: Probable methyltransferase (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for METTL22
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): METTL22 promoter sequence

Search SABiosciences Chromatin IP Primers for METTL22

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL22

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.2 Ensembl cytogenetic band: 16p13.2 HGNC cytogenetic band: 16p13.2

METTL22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
METTL22 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P008717: view genomic region (about GC identifiers)

Start:	8,715,527 bp from pter	End:	8,740,081 bp from pter
Size:	24,555 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MET22_HUMAN, Q9BUU2 (See protein sequence)

Recommended Name: Methyltransferase-like protein 22

Size: 404 amino acids; 44486 Da

Secondary accessions: B2RD29 D3DUF2 Q6XYB4 Q9HA03

Alternative splicing: 3 isoforms: Q9BUU2-1 Q9BUU2-2 Q9BUU2-3

Explore the universe of human proteins at neXtProt for METTL22: NX_Q9BUU2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BUU2

METTL22 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_077014.2

ENSEMBL proteins:

ENSP00000457291 ENSP00000371345 ENSP00000163678 ENSP00000456618 ENSP00000457152

ENSP00000457913 ENSP00000459729 ENSP00000457191 ENSP00000461054 ENSP00000460481

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

METTL22 for domains About GeneDecksing

1 InterPro domain/family:

IPR019410 Nicotinamide_N-MeTfrase-like

Graphical View of Domain Structure for InterPro Entry Q9BUU2

ProtoNet protein and cluster: Q9BUU2

UniProtKB/Swiss-Prot: MET22_HUMAN, Q9BUU2

Similarity: Belongs to the methyltransferase superfamily. METTL22 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MET22_HUMAN, Q9BUU2

Function: Probable methyltransferase (By similarity)

Enzyme Number (IUBMB): EC 2.1.1.-¹

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004871	signal transducer activity	--	--
GO:0008168	methyltransferase activity	IEA	--

METTL22 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for METTL22:

Decreased cell number and incr

Increased gamma-H2AX phosphory

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for METTL22

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL22

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for METTL22

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000160	phosphorelay signal transduction system	--	--

METTL22 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for METTL22
Search CenterWatch for drugs/clinical trials and news about METTL22 / MET22

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for METTL22 gene:

NM_024109.2

Unigene Cluster for METTL22:

Methyltransferase like 22

Hs.306380 [show with all ESTs]

Unigene Representative Sequence: AK000114

18 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000563958 ENST00000381920(uc002cyz.3 uc021tcq.1) ENST00000163678

ENST00000564554 ENST00000561758 ENST00000567295 ENST00000563037 ENST00000568967

ENST00000564624 ENST00000572956 ENST00000561993 ENST00000563501 ENST00000565866

ENST00000562151 ENST00000564107 ENST00000564133 ENST00000562973 ENST00000569597

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Additional cDNA sequence:

AK000114.1 AK022495.1 AK315383.1 AY203956.1 BC001908.1 BC103725.1

18 DOTS entries:

DT.100789571 DT.100772526 DT.97813690 DT.95363604 DT.97771022 DT.313205 DT.92428807 DT.92428804

DT.100789570 DT.120691103 DT.40203763 DT.100019848 DT.91946355 DT.100789568 DT.120691086 DT.92428803

DT.100789572 DT.91988403

24/152 AceView cDNA sequences (see all 152):

BQ070552 BM681314 CR604742 CR621296 CB157733 CR612148 BF435894 BE696679

AU122809 BG831181 BI913995 BI772094 CB152603 BE264507 BX420794 BC001908

BQ448675 BM041884 BE562440 CD518040 BU185284 BE393108 BP429595 BQ680034

GeneLoc Exon Structure

5/17 Alternative Splicing Database (ASD) splice patterns (SP) for METTL22 (see all 17) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	·	2c	·	2d	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	^	8a	·	8b	^	9	^	10a	·	10b	·	10c	·	10d	^	11a	·	11b	^	12	^	13	^
SP1:									-		-		-		-																				-												-		-
SP2:									-		-		-		-												-		-																		-		-
SP3:																																															-		-
SP4:																																															-		-
SP5:																																			-												-		-

ExUns:	14	^	15a	·	15b	^	16a	·	16b	·	16c	·	16d	^	17a	·	17b	·	17c	^	18
SP1:	-		-										-		-
SP2:	-		-
SP3:	-		-
SP4:	-		-										-
SP5:	-		-

ECgene alternative splicing isoforms for METTL22

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

METTL22 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCCATCGCC

About this image

METTL22 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

6 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Autopod Long Bone

Bone

Endochondral Facial Bones

Bone

Bone

Bone

Bone

Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See METTL22 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for METTL22

SOURCE GeneReport for Unigene cluster: Hs.306380

SABiosciences Custom PCR Arrays for METTL22

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for METTL22 gene from 7/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mettl22^{1 , 5}	methyltransferase like 22^{1, 5}	82(n)¹ 80.36(a)¹		16 (3.97 cM)⁵ 239706¹ NM_146247.1¹ NP_666359.1¹ 8470788⁵
chicken (Gallus gallus)	Aves	METTL22¹	methyltransferase like 22	61.82(n) 57.8(a)		425865 NM_001031350.1 NP_001026521.1
lizard (Anolis carolinensis)	Reptilia	METTL22⁶	--	54(a)	1 ↔ 1	GL343263.1(863948-869942)
zebrafish (Danio rerio)	Actinopterygii	zgc:194177¹	zgc:194177	63.41(n) 58.33(a)		796066 NM_001177460.1 NP_001170931.1
fruit fly (Drosophila melanogaster)	Insecta	CG10584¹	CG10584	46.92(n) 40.28(a)		40324 NM_141021.2 NP_649278.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G79915¹	Putative methyltransferase family protein	47.16(n) 36.24(a)		844331 NM_148669.4 NP_683510.4
rice (Oryza sativa)	Liliopsida	Os06g0639300¹	hypothetical protein	47.27(n) 38.55(a)		4341620 NM_001064694.1 NP_001058159.1

ENSEMBL Gene Tree for METTL22 (if available)
TreeFam Gene Tree for METTL22 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147024404^1,2		--	8713613(+)	`CAAACC/TACCTC`	1	--	us2k¹		0	--	--	--	--
rs138232349^1,2		--	8713647(+)	`CCCTTC/TTGGGG`	1	--	us2k¹		0	--	--	--	--
rs149580019^1,2		--	8713816(+)	`ATGACA/GGAAGA`	1	--	us2k¹		0	--	--	--	--
rs6416652^1,2	C,F,H	--	8713821(+)	`AGAAGG/AAGTGA`	1	--	us2k¹		13		NA WA CSA EA	376
rs144357223^1,2		--	8713901(+)	`AGGAAA/TGTGAT`	1	--	us2k¹		0	--	--	--	--
rs187237319^1,2		--	8713934(+)	`CCCCCA/GGTTTA`	1	--	us2k¹		0	--	--	--	--
rs148765245^1,2		--	8714033(+)	`ACCCTC/TAGCGA`	1	--	us2k¹		0	--	--	--	--
rs190914034^1,2		--	8714040(+)	`GCGAAC/GTAGAG`	1	--	us2k¹		0	--	--	--	--
rs142286134^1,2		--	8714123(+)	`GAAACA/GTAATC`	1	--	us2k¹		0	--	--	--	--
rs7194934^1,2	C,F,A,H	--	8714162(+)	`TTCTTC/ATTTGT`	1	--	us2k¹		13		NA WA CSA EA	378

HapMap Linkage Disequilibrium report for METTL22 (8715527 - 8740081 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for METTL22: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing METTL22

DNA2.0 Custom Variant and Variant Library Synthesis for METTL22

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for METTL22 gene integrated from 9 sources:
(articles sorted by number of sources associating them with METTL22)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)² Martin J.... Pennacchio L.A. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)² Wan D....Gu J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 79091	HGNC: 28368	AceView: MGC2654	Ensembl:ENSG00000067365	euGenes: HUgn79091
ECgene: METTL22	H-InvDB: METTL22

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for METTL22	Pharmacogenomics, SNPs, Pathways

Intellectual Property for METTL22 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for METTL22 gene:
Search GeneIP for patents involving METTL22

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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	Browse OriGene Antibodies		OriGene shRNA RFP for METTL22
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for METTL22		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for METTL22
	OriGene Protein Over-expression Lysate for METTL22		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for METTL22		OriGene 3'-UTR Clone for METTL22
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL22		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL22
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	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for METTL22		OriGene Custom Protein Services for METTL22
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat METTL22
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing METTL22
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL22
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat METTL22
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL22
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL22

	GenScript Custom Purified and Recombinant Proteins Services for METTL22		GenScript cDNA clones with any tag delivered in your preferred vector for METTL22
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	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL22

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for METTL22

Sirion Biotech Customized:

	stable knockdown cell line services for METTL22
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	design and validation of potent shRNA sequences against METTL22
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	stable overexpressing cell line services for METTL22
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes METTL22 gene at Home site.

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METTL22 Gene

methyltransferase like 22

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METTL22 Gene

methyltransferase like 22

Aliasesfor METTL22 gene

Summariesfor METTL22 gene

Genomic Viewsfor METTL22 gene

Proteinsfor METTL22 gene

Protein Domains /Familiesfor METTL22 gene

Functionfor METTL22 gene

Pathways & Interactionsfor METTL22 gene

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for METTL22 gene

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for METTL22 gene

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for METTL22 gene

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for METTL22 gene

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for METTL22 gene

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for METTL22 gene

Expression
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for METTL22 gene

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