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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

METTL22 Gene

protein-coding   GIFtS: 43
GCID: GC16P008717

Methyltransferase Like 22

(Previous name: chromosome 16 open reading frame 68)
(Previous symbol: C16orf68)
  Search for METTL22
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Methyltransferase Like 221 2
C16orf681 2 3
Chromosome 16 Open Reading Frame 681
LP82722
Methyltransferase-Like Protein 222
EC 2.1.1.-3

External Ids:    HGNC: 283681   Entrez Gene: 790912   Ensembl: ENSG000000673657   OMIM: 6152615   UniProtKB: Q9BUU23   

Export aliases for METTL22 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for METTL22 Gene: 
METTL22 (methyltransferase like 22) is a protein-coding gene. GO annotations related to this gene include methyltransferase activity.

UniProtKB/Swiss-Prot: MET22_HUMAN, Q9BUU2
Function: Protein N-lysine methyltransferase. In vitro methylates KIN




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for METTL22
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): METTL22 promoter sequence
   Search SABiosciences Chromatin IP Primers for METTL22

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.2   Ensembl cytogenetic band:  16p13.2   HGNC cytogenetic band: 16p13.2

METTL22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
METTL22 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P008717:  view genomic region     (about GC identifiers)

Start:
8,715,527 bp from pter      End:
8,740,081 bp from pter
Size:
24,555 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MET22_HUMAN, Q9BUU2 (See protein sequence)
Recommended Name: Methyltransferase-like protein 22  
Size: 404 amino acids; 44486 Da
Subunit: Interacts with members of the heat shock protein 90 and 70 families; these proteins probably are
methylation substrates (PubMed:23349634)
Subcellular location: Nucleus
Secondary accessions: B2RD29 D3DUF2 Q6XYB4 Q9HA03
Alternative splicing: 3 isoforms:  Q9BUU2-1   Q9BUU2-2   Q9BUU2-3   

Explore the universe of human proteins at neXtProt for METTL22: NX_Q9BUU2

Explore proteomics data for METTL22 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BUU2

  • METTL22 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    METTL22 Protein Expression
    REFSEQ proteins: NP_077014.2  
    ENSEMBL proteins: 
     ENSP00000457291   ENSP00000371345   ENSP00000163678   ENSP00000456618   ENSP00000457152  
     ENSP00000457913   ENSP00000459729   ENSP00000457191   ENSP00000461054   ENSP00000460481  

    Human Recombinant Protein Products for METTL22: 
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    OriGene Protein Over-expression Lysate for METTL22
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for METTL22
    GenScript Custom Purified and Recombinant Proteins Services for METTL22
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for METTL22 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    METTL22 for ontologies           About GeneDecksing



    METTL22 Antibody Products: 
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    Novus Biologicals METTL22 Antibody
    Abcam antibodies for METTL22
    Cloud-Clone Corp. Antibodies for METTL22 
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    Assay Products for METTL22: 
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    Cloud-Clone Corp. ELISAs for METTL22 
    Cloud-Clone Corp. CLIAs for METTL22


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR019410 Nicotinamide_N-MeTfrase-like

    Graphical View of Domain Structure for InterPro Entry Q9BUU2

    ProtoNet protein and cluster: Q9BUU2

    UniProtKB/Swiss-Prot: MET22_HUMAN, Q9BUU2
    Similarity: Belongs to the methyltransferase superfamily. METTL22 family


    METTL22 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MET22_HUMAN, Q9BUU2
    Function: Protein N-lysine methyltransferase. In vitro methylates KIN

         Enzyme Number (IUBMB): EC 2.1.1.-1

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008168methyltransferase activity IEA--
         
    METTL22 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for METTL22:
     Decreased cell number and incr  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for METTL22 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for METTL22

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for METTL22 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for METTL22 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat METTL22
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate METTL22
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for METTL22
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat METTL22

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for METTL22
    Sirion Biotech Customized adenovirus for overexpression of METTL22

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for METTL22 (see all 8)
    OriGene ORF clones in mouse, rat for METTL22
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: METTL22 (NM_024109)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for METTL22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL22
    Sirion Biotech Customized lentivirus for stable overexpression of METTL22 
                         Customized lentivirus expression plasmids for stable overexpression of METTL22 

    Cell Line
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    Search LifeMap BioReagents cell lines for METTL22
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL22


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for METTL22

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for METTL22 (MET22)

    Search CenterWatch for drugs/clinical trials and news about METTL22 / MET22

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for METTL22 gene: 
    NM_024109.2  

    Unigene Cluster for METTL22:

    Methyltransferase like 22
    Hs.306380  [show with all ESTs]
    Unigene Representative Sequence: AK000114
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000563958 ENST00000381920(uc002cyz.3 uc021tcq.1) ENST00000163678
    ENST00000564554 ENST00000561758 ENST00000567295 ENST00000563037 ENST00000568967
    ENST00000564624 ENST00000572956 ENST00000561993 ENST00000563501 ENST00000565866
    ENST00000562151 ENST00000564107 ENST00000564133 ENST00000562973 ENST00000569597

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat METTL22
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate METTL22
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for METTL22
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat METTL22
    Clone
    Products:
         
    OriGene clones in human, mouse for METTL22 (see all 8)
    OriGene ORF clones in mouse, rat for METTL22
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: METTL22 (NM_024109)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for METTL22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL22
    Sirion Biotech Customized lentivirus for stable overexpression of METTL22 
                         Customized lentivirus expression plasmids for stable overexpression of METTL22 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for METTL22
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat METTL22
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL22
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL22

    Additional mRNA sequence: 

    AK000114.1 AK022495.1 AK315383.1 AY203956.1 BC001908.1 BC103725.1 

    18 DOTS entries:

    DT.100789571  DT.100772526  DT.97813690  DT.95363604  DT.97771022  DT.313205  DT.92428807  DT.92428804 
    DT.100789570  DT.120691103  DT.40203763  DT.100019848  DT.91946355  DT.100789568  DT.120691086  DT.92428803 
    DT.100789572  DT.91988403 

    24/152 AceView cDNA sequences (see all 152):

    CB152603 BI772094 AU122809 BI913995 BG831181 BE696679 BQ070552 BM681314 
    CR604742 CR612148 CR621296 CB157733 BF435894 BE935837 NM_024109 AX747763 
    BX399093 BU172116 AL598837 CA416956 BU931158 BM683164 BP429595 BE393108 

    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for METTL22 (see all 17)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13 ^
    SP1:                          -     -     -     -                                                           -                                   -     -         
    SP2:                          -     -     -     -                                   -     -                                                     -     -         
    SP3:                                                                                                                                            -     -         
    SP4:                                                                                                                                            -     -         
    SP5:                                                                                                        -                                   -     -         

    ExUns: 14 ^ 15a · 15b ^ 16a · 16b · 16c · 16d ^ 17a · 17b · 17c ^ 18
    SP1:  -     -                             -     -                     
    SP2:  -     -                                                         
    SP3:  -     -                                                         
    SP4:  -     -                             -                           
    SP5:  -     -                                                         


    ECgene alternative splicing isoforms for METTL22

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    METTL22 expression in normal human tissues (normalized intensities)      METTL22 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCCATCGCC
    METTL22 Expression
    About this image


    METTL22 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 10 entries
             Zeugopod Long Bone
             skeleton/pectoral girdle and thoracic body wall/scapula   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 6 entries
             Meckel's Cartilage
             sensory organ/nose/nasal septum   
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 3 entries
             skeleton/cranium/chondrocranium   
     
     Nose (Sensory Organs)
             sensory organ/nose/nasal septum   
     
     Mesoderm (Gastrulation Derivatives)
             skeleton/axial skeleton   

    See METTL22 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for METTL22

    SOURCE GeneReport for Unigene cluster: Hs.306380
        SABiosciences Custom PCR Arrays for METTL22
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL22
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL22

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for METTL22 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mettl221 , 5 methyltransferase like 221, 5 82(n)1
    80.36(a)1
      16 (3.97 cM)5
    2397061  NM_146247.11  NP_666359.11 
     84707885 
    chicken
    (Gallus gallus)
    Aves METTL221 methyltransferase like 22 61.82(n)
    57.8(a)
      425865  NM_001031350.1  NP_001026521.1 
    lizard
    (Anolis carolinensis)
    Reptilia METTL226
    Uncharacterized protein
    54(a)
    1 ↔ 1
    GL343263.1(863948-869942)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1941771 zgc:194177 63.41(n)
    58.33(a)
      796066  NM_001177460.1  NP_001170931.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG105841 CG10584 46.92(n)
    40.28(a)
      40324  NM_141021.2  NP_649278.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G799151 Putative methyltransferase family protein 47.16(n)
    36.24(a)
      844331  NM_148669.4  NP_683510.4 
    rice
    (Oryza sativa)
    Liliopsida Os06g06393001 hypothetical protein 47.27(n)
    38.55(a)
      4341620  NM_001064694.1  NP_001058159.1 


    ENSEMBL Gene Tree for METTL22 (if available)
    TreeFam Gene Tree for METTL22 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/957 SNPs in METTL22 are shown (see all 957)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1470244041,2
    --8713613(+) CAAACC/TACCTC 1 -- us2k10--------
    rs1382323491,2
    --8713647(+) CCCTTC/TTGGGG 1 -- us2k10--------
    rs1495800191,2
    --8713816(+) ATGACA/GGAAGA 1 -- us2k10--------
    rs64166521,2
    C,F,H--8713821(+) AGAAGG/AAGTGA 1 -- us2k113Minor allele frequency- A:0.11NA WA CSA EA 376
    rs1443572231,2
    --8713901(+) AGGAAA/TGTGAT 1 -- us2k10--------
    rs1872373191,2
    --8713934(+) CCCCCA/GGTTTA 1 -- us2k10--------
    rs1487652451,2
    C--8714033(+) ACCCTC/TAGCGA 1 -- us2k10--------
    rs1909140341,2
    --8714040(+) GCGAAC/GTAGAG 1 -- us2k10--------
    rs1422861341,2
    C--8714123(+) GAAACA/GTAATC 1 -- us2k10--------
    rs343390721,2
    C--8714156(+) AAAAA-/A/AAA 
            
    TTCTT
    2 -- us2k1 cds11NA 2

    HapMap Linkage Disequilibrium report for METTL22 (8715527 - 8740081 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for METTL22:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1261959CNV Insertion17803354
    esv1322482CNV Insertion17803354
    nsv905305CNV Loss21882294
    nsv827546CNV Gain20364138

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing METTL22
    DNA2.0 Custom Variant and Variant Library Synthesis for METTL22

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    METTL22 for disorders           About MalaCards
    OMIM gene information: 615261    OMIM disorders: --


    METTL22 for disorders           About GeneDecksing


    Export disorders for METTL22 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for METTL22 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with METTL22)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1, 2 Cloutier P.... Coulombe B. (2013)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)2 Wan D....Gu J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79091 HGNC: 28368 AceView: MGC2654 Ensembl:ENSG00000067365 euGenes: HUgn79091
    ECgene: METTL22 H-InvDB: METTL22

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for METTL22 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for METTL22 gene:
    Search GeneIP for patents involving METTL22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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