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Aliases for METTL22 Gene

Aliases for METTL22 Gene

  • Methyltransferase Like 22 2 3 5
  • C16orf68 3 4
  • Chromosome 16 Open Reading Frame 68 2
  • EC 2.1.1.- 4
  • LP8272 3

External Ids for METTL22 Gene

Previous HGNC Symbols for METTL22 Gene

  • C16orf68

Previous GeneCards Identifiers for METTL22 Gene

  • GC16P008717

Summaries for METTL22 Gene

Entrez Gene Summary for METTL22 Gene

  • This gene encodes a member of the non-histone lysine methyltransferases. It interacts with its substrate, Kin17, which is involved in DNA repair and replication and mRNA processing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for METTL22 Gene

METTL22 (Methyltransferase Like 22) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity.

UniProtKB/Swiss-Prot for METTL22 Gene

  • Protein N-lysine methyltransferase. In vitro methylates KIN.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL22 Gene

Genomics for METTL22 Gene

Regulatory Elements for METTL22 Gene

Enhancers for METTL22 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around METTL22 on UCSC Golden Path with GeneCards custom track

Promoters for METTL22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around METTL22 on UCSC Golden Path with GeneCards custom track

Genomic Location for METTL22 Gene

8,621,640 bp from pter
8,661,208 bp from pter
39,569 bases
Plus strand

Genomic View for METTL22 Gene

Genes around METTL22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL22 Gene

Proteins for METTL22 Gene

  • Protein details for METTL22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Methyltransferase-like protein 22
    Protein Accession:
    Secondary Accessions:
    • B2RD29
    • D3DUF2
    • Q6XYB4
    • Q9HA03

    Protein attributes for METTL22 Gene

    404 amino acids
    Molecular mass:
    44486 Da
    Quaternary structure:
    • Interacts with members of the heat shock protein 90 and 70 families; these proteins probably are methylation substrates.

    Alternative splice isoforms for METTL22 Gene


neXtProt entry for METTL22 Gene

Proteomics data for METTL22 Gene at MOPED

Post-translational modifications for METTL22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for METTL22 Gene

Domains & Families for METTL22 Gene

Gene Families for METTL22 Gene

Protein Domains for METTL22 Gene

Suggested Antigen Peptide Sequences for METTL22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the methyltransferase superfamily. METTL22 family.
  • Belongs to the methyltransferase superfamily. METTL22 family.
genes like me logo Genes that share domains with METTL22: view

Function for METTL22 Gene

Molecular function for METTL22 Gene

UniProtKB/Swiss-Prot Function:
Protein N-lysine methyltransferase. In vitro methylates KIN.

Enzyme Numbers (IUBMB) for METTL22 Gene

genes like me logo Genes that share phenotypes with METTL22: view

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL22 Gene

Localization for METTL22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL22 Gene

Subcellular locations from

Jensen Localization Image for METTL22 Gene COMPARTMENTS Subcellular localization image for METTL22 gene
Compartment Confidence
nucleus 5
golgi apparatus 4
plasma membrane 4
cytosol 2

Gene Ontology (GO) - Cellular Components for METTL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with METTL22: view

Pathways & Interactions for METTL22 Gene

SuperPathways for METTL22 Gene

No Data Available

Interacting Proteins for METTL22 Gene

Gene Ontology (GO) - Biological Process for METTL22 Gene


No data available for Pathways by source and SIGNOR curated interactions for METTL22 Gene

Drugs & Compounds for METTL22 Gene

No Compound Related Data Available

Transcripts for METTL22 Gene

Unigene Clusters for METTL22 Gene

Methyltransferase like 22:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for METTL22 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13 ^
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - -
SP4: - -
SP5: - - -
SP6: - - - -
SP9: - -
SP10: - - - - - -
SP11: -
SP12: - -
SP13: - - - - - - - - - - -
SP14: - - -

ExUns: 14 ^ 15a · 15b ^ 16a · 16b · 16c · 16d ^ 17a · 17b · 17c ^ 18
SP1: - - - -
SP2: - -
SP3: - -
SP4: - - -
SP5: - -
SP8: - - -

Relevant External Links for METTL22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL22 Gene

mRNA expression in normal human tissues for METTL22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for METTL22 Gene

This gene is overexpressed in Muscle - Skeletal (x4.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for METTL22 Gene

SOURCE GeneReport for Unigene cluster for METTL22 Gene Hs.306380

genes like me logo Genes that share expression patterns with METTL22: view

Primer Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for METTL22 Gene

Orthologs for METTL22 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METTL22 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia METTL22 35
  • 81.02 (n)
  • 80.53 (a)
METTL22 36
  • 77 (a)
(Canis familiaris)
Mammalia METTL22 35
  • 82.29 (n)
  • 81.25 (a)
METTL22 36
  • 81 (a)
(Mus musculus)
Mammalia Mettl22 35
  • 82.26 (n)
  • 80.88 (a)
Mettl22 16
Mettl22 36
  • 79 (a)
(Pan troglodytes)
Mammalia METTL22 35
  • 98.68 (n)
  • 99.01 (a)
METTL22 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Mettl22 35
  • 82.43 (n)
  • 80.88 (a)
(Monodelphis domestica)
Mammalia METTL22 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia METTL22 36
  • 63 (a)
(Gallus gallus)
Aves METTL22 35
  • 61.98 (n)
  • 59.64 (a)
METTL22 36
  • 55 (a)
(Anolis carolinensis)
Reptilia METTL22 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl22 35
  • 56.89 (n)
  • 53.07 (a)
(Danio rerio)
Actinopterygii mettl22 35
  • 62.98 (n)
  • 59.59 (a)
mettl22 36
  • 57 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011879 35
  • 45.32 (n)
  • 32.81 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10584 35
  • 47.08 (n)
  • 40.28 (a)
CG10584 36
  • 36 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G79915 35
  • 47.16 (n)
  • 36.24 (a)
(Oryza sativa)
Liliopsida Os06g0639300 35
  • 47.13 (n)
  • 38.83 (a)
Species with no ortholog for METTL22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for METTL22 Gene

Gene Tree for METTL22 (if available)
Gene Tree for METTL22 (if available)

Paralogs for METTL22 Gene

No data available for Paralogs for METTL22 Gene

Variants for METTL22 Gene

Sequence variations from dbSNP and Humsavar for METTL22 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs2270286 - 8,628,772(+) CTCTT(C/G)GACAG nc-transcript-variant, upstream-variant-2KB, reference, missense
rs2302607 - 8,635,267(+) GGCTC(A/G)CTAGC nc-transcript-variant, reference, missense, utr-variant-5-prime
rs1731000 - 8,644,642(-) ATCTG(C/T)GAGCT intron-variant, nc-transcript-variant, reference, missense
rs55747257 - 8,644,669(+) TGGTG(A/C/G)AGCCC intron-variant, nc-transcript-variant, reference, missense
rs1379 -- 8,649,370(-) TCCCC(A/G)TGGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for METTL22 Gene

Variant ID Type Subtype PubMed ID
nsv905305 CNV Loss 21882294
nsv827546 CNV Gain 20364138
esv1261959 CNV Insertion 17803354
esv1322482 CNV Insertion 17803354

Variation tolerance for METTL22 Gene

Residual Variation Intolerance Score: 90.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.15; 80.73% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for METTL22 Gene

Disorders for METTL22 Gene

Relevant External Links for METTL22

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for METTL22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL22 Gene

Publications for METTL22 Gene

  1. Methylation of the DNA/RNA-binding protein Kin17 by METTL22 affects its association with chromatin. (PMID: 24140279) Cloutier P. … Coulombe B. (J Proteomics 2014) 2 3 67
  2. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P. … Coulombe B. (PLoS Genet. 2013) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for METTL22 Gene

Sources for METTL22 Gene