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METTL22 Gene

protein-coding   GIFtS: 44
GCID: GC16P008717

Methyltransferase Like 22

(Previous name: chromosome 16 open reading frame 68)
(Previous symbol: C16orf68)
  Search for METTL22
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Methyltransferase Like 221 2
C16orf681 2 3 5
Chromosome 16 Open Reading Frame 681
LP82722
Methyltransferase-Like Protein 222
EC 2.1.1.-3

External Ids:    HGNC: 283681   Entrez Gene: 790912   Ensembl: ENSG000000673657   OMIM: 6152615   UniProtKB: Q9BUU23   

Export aliases for METTL22 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for METTL22 Gene:
METTL22 (methyltransferase like 22) is a protein-coding gene. GO annotations related to this gene include methyltransferase activity.

UniProtKB/Swiss-Prot: MET22_HUMAN, Q9BUU2
Function: Protein N-lysine methyltransferase. In vitro methylates KIN




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010393.17  NC_018927.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for METTL22
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): METTL22 promoter sequence
   Search Chromatin IP Primers for METTL22

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat METTL22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.2   Ensembl cytogenetic band:  16p13.2   HGNC cytogenetic band: 16p13.2

METTL22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
METTL22 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P008717:  view genomic region     (about GC identifiers)

Start:
8,715,527 bp from pter      End:
8,740,081 bp from pter
Size:
24,555 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MET22_HUMAN, Q9BUU2 (See protein sequence)
Recommended Name: Methyltransferase-like protein 22  
Size: 404 amino acids; 44486 Da
Subunit: Interacts with members of the heat shock protein 90 and 70 families; these proteins probably are
methylation substrates (PubMed:23349634)
Secondary accessions: B2RD29 D3DUF2 Q6XYB4 Q9HA03
Alternative splicing: 3 isoforms:  Q9BUU2-1   Q9BUU2-2   Q9BUU2-3   

Explore the universe of human proteins at neXtProt for METTL22: NX_Q9BUU2

Explore proteomics data for METTL22 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See METTL22 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_077014.2  
    ENSEMBL proteins: 
     ENSP00000457291   ENSP00000371345   ENSP00000163678   ENSP00000456618   ENSP00000457152  
     ENSP00000457913   ENSP00000459729   ENSP00000457191   ENSP00000461054   ENSP00000460481  

    METTL22 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for METTL22
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for METTL22

     
    Search eBioscience for Proteins for METTL22 

    METTL22 Antibody Products:

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    Novus Biologicals METTL22 Antibody
    Abcam antibodies for METTL22
    Cloud-Clone Corp. Antibodies for METTL22
    Search ThermoFisher Antibodies for METTL22
    Search LSBio for Antibodies for METTL22

    METTL22 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for METTL22
    Cloud-Clone Corp. CLIAs for METTL22
    Search eBioscience for ELISAs for METTL22 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019410 Nicotinamide_N-MeTfrase-like

    Graphical View of Domain Structure for InterPro Entry Q9BUU2

    ProtoNet protein and cluster: Q9BUU2

    UniProtKB/Swiss-Prot: MET22_HUMAN, Q9BUU2
    Similarity: Belongs to the methyltransferase superfamily. METTL22 family


    Find genes that share domains with METTL22           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MET22_HUMAN, Q9BUU2
    Function: Protein N-lysine methyltransferase. In vitro methylates KIN

         Enzyme Number (IUBMB): EC 2.1.1.-1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008168methyltransferase activity IEA--
         
    Find genes that share ontologies with METTL22           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for METTL22:
     Decreased cell number and incr  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for METTL22
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for METTL22

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for METTL22
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for METTL22

    miRNA
    Products:
        
    miRTarBase miRNAs that target METTL22:
    hsa-mir-20a-5p (MIRT050513)

    Block miRNA regulation of human, mouse, rat METTL22 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate METTL22
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for METTL22
    Predesigned siRNA for gene silencing in human, mouse, rat METTL22

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for METTL22

    Clone
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    OriGene clones in human, mouse for METTL22 (see all 7)
    OriGene ORF clones in mouse, rat for METTL22
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: METTL22 (NM_024109)
    Sino Biological Human cDNA Clone for METTL22
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for METTL22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL22

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for METTL22 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL22


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MET22_HUMAN, Q9BUU2: Nucleus

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with METTL22           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for METTL22
    Interactions:

        Search GeneGlobe Interaction Network for METTL22

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for METTL22 (MET22)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for METTL22 gene: 
    NM_024109.2  

    Unigene Cluster for METTL22:

    Methyltransferase like 22
    Hs.306380  [show with all ESTs]
    Unigene Representative Sequence: AK000114
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000563958 ENST00000381920(uc002cyz.3 uc021tcq.1) ENST00000163678
    ENST00000564554 ENST00000561758 ENST00000567295 ENST00000563037 ENST00000568967
    ENST00000564624 ENST00000572956 ENST00000561993 ENST00000563501 ENST00000565866
    ENST00000562151 ENST00000564107 ENST00000564133 ENST00000562973 ENST00000569597

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat METTL22 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate METTL22
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for METTL22
    Predesigned siRNA for gene silencing in human, mouse, rat METTL22
    Clone
    Products:
         
    OriGene clones in human, mouse for METTL22 (see all 7)
    OriGene ORF clones in mouse, rat for METTL22
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: METTL22 (NM_024109)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for METTL22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL22
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for METTL22
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat METTL22
      QuantiTect SYBR Green Assays in human, mouse, rat METTL22
      QuantiFast Probe-based Assays in human, mouse, rat METTL22

    Additional mRNA sequence: 

    AK000114.1 AK022495.1 AK315383.1 AY203956.1 BC001908.1 BC103725.1 

    18 DOTS entries:

    DT.100789571  DT.100772526  DT.97813690  DT.95363604  DT.97771022  DT.313205  DT.92428807  DT.92428804 
    DT.100789570  DT.120691103  DT.40203763  DT.100019848  DT.91946355  DT.100789568  DT.120691086  DT.92428803 
    DT.100789572  DT.91988403 

    Selected AceView cDNA sequences (see all 152):

    CB152603 BI772094 AU122809 BI913995 BG831181 BE696679 BQ070552 BM681314 
    CR604742 CR612148 CR621296 CB157733 BF435894 BE935837 NM_024109 AX747763 
    BX399093 BU172116 AL598837 CA416956 BU931158 BM683164 BP429595 BE393108 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for METTL22 (see all 17)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13 ^
    SP1:                          -     -     -     -                                                           -                                   -     -         
    SP2:                          -     -     -     -                                   -     -                                                     -     -         
    SP3:                                                                                                                                            -     -         
    SP4:                                                                                                                                            -     -         
    SP5:                                                                                                        -                                   -     -         

    ExUns: 14 ^ 15a · 15b ^ 16a · 16b · 16c · 16d ^ 17a · 17b · 17c ^ 18
    SP1:  -     -                             -     -                     
    SP2:  -     -                                                         
    SP3:  -     -                                                         
    SP4:  -     -                             -                           
    SP5:  -     -                                                         


    ECgene alternative splicing isoforms for METTL22

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    METTL22 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCCATCGCC
    METTL22 Expression
    About this image


    METTL22 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             Zeugopod Long Bone
     
     Limb (Muscoskeletal System)
             Pelvic Girdle
     
     Cartilage (Muscoskeletal System)
             Meckel's Cartilage
    METTL22 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    METTL22 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.306380
        Custom PCR Arrays for METTL22
    Primer
    Products:
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL22

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for METTL22 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mettl221 , 5 methyltransferase like 221, 5 82.26(n)1
    80.88(a)1
      16 (3.97 cM)5
    2397061  NM_146247.11  NP_666359.11 
     84707885 
    chicken
    (Gallus gallus)
    Aves METTL221 methyltransferase like 22 61.98(n)
    59.64(a)
      425865  NM_001278154.1  NP_001265083.1 
    lizard
    (Anolis carolinensis)
    Reptilia METTL226
    methyltransferase like 22
    56(a)
    1 ↔ 1
    GL343263.1(863948-869942)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mettl221 methyltransferase like 22 56.89(n)
    53.07(a)
      100145759  NM_001127130.1  NP_001120602.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mettl221 methyltransferase like 22 62.98(n)
    59.59(a)
      796066  NM_001177460.1  NP_001170931.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG105841 CG10584 47.08(n)
    40.28(a)
      40324  NM_141021.2  NP_649278.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G799151 AT1G79915 47.16(n)
    36.24(a)
      844331  NM_148669.4  NP_683510.4 
    rice
    (Oryza sativa)
    Liliopsida Os06g06393001 Os06g0639300 47.13(n)
    38.83(a)
      4341620  NM_001064694.1  NP_001058159.1 


    ENSEMBL Gene Tree for METTL22 (if available)
    TreeFam Gene Tree for METTL22 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for METTL22 (see all 957)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1470244041,2
    --8713613(+) CAAACC/TACCTC 1 -- us2k10--------
    rs1382323491,2
    --8713647(+) CCCTTC/TTGGGG 1 -- us2k10--------
    rs1495800191,2
    --8713816(+) ATGACA/GGAAGA 1 -- us2k10--------
    rs64166521,2
    C,F,H--8713821(+) AGAAGG/AAGTGA 1 -- us2k113Minor allele frequency- A:0.11NA WA CSA EA 376
    rs1443572231,2
    --8713901(+) AGGAAA/TGTGAT 1 -- us2k10--------
    rs1872373191,2
    --8713934(+) CCCCCA/GGTTTA 1 -- us2k10--------
    rs1487652451,2
    C--8714033(+) ACCCTC/TAGCGA 1 -- us2k10--------
    rs1909140341,2
    --8714040(+) GCGAAC/GTAGAG 1 -- us2k10--------
    rs1422861341,2
    C--8714123(+) GAAACA/GTAATC 1 -- us2k10--------
    rs343390721,2
    C--8714156(+) AAAAA-/A/AAA 
            
    TTCTT
    2 -- us2k1 cds11NA 2

    HapMap Linkage Disequilibrium report for METTL22 (8715527 - 8740081 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for METTL22:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1261959CNV Insertion17803354
    esv1322482CNV Insertion17803354
    nsv905305CNV Loss21882294
    nsv827546CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing METTL22
    DNA2.0 Custom Variant and Variant Library Synthesis for METTL22

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615261    OMIM disorders: --


    Find genes that share disorders with METTL22           About GenesLikeMe


    Export disorders for METTL22 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for METTL22 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with METTL22)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1, 2 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    6. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (Nature 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79091 HGNC: 28368 AceView: MGC2654 Ensembl:ENSG00000067365 euGenes: HUgn79091
    ECgene: METTL22 H-InvDB: METTL22

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for METTL22 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for METTL22 gene:
    Search GeneIP for patents involving METTL22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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