METTL21D Gene
protein-coding GIFtS: 40
GCID: GC14M050576
|
|
methyltransferase like 21D(Previous name: chromosome 14 open reading frame 138 )
(Previous symbol: C14orf138)
| |
Aliases
for METTL21D gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Methyltransferase Like 21D1 2 | | VCP Lysine Methyltransferase2 3 | | C14orf1381 2 3 | | Chromosome 14 Open Reading Frame 1381 | | Methyltransferase-Like Protein 21D2 3 | | Protein-Lysine Methyltransferase METTL21D2 | | VCP-KMT2 3 | | EC 2.1.1.-3 |
Export aliases for METTL21D gene to outside databases |
Summaries
for METTL21D gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MT21D_HUMAN, Q9H867Function: Protein-lysine N-methyltransferase that specifically trimethylates 'Lys-315' of VCP/p97
|
Genomic Views
for METTL21D gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for METTL21D
Other transcription factors
Search SABiosciences Chromatin IP Primers for METTL21D
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL21D |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q21.3 Ensembl cytogenetic band: 14q21.3 HGNC cytogenetic band: 14q21.3METTL21D Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M050576: view genomic region
(about GC identifiers)
Start:
|
50,575,350 bp from pter |
End:
|
50,583,318 bp from pter |
Size:
|
7,969 bases |
Orientation:
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minus strand |
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Proteins
for METTL21D gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MT21D_HUMAN, Q9H867 (See
protein sequence)Recommended Name: Protein-lysine methyltransferase METTL21D Size: 229 amino acids; 25807 Da
Subunit: Interacts with ALKBH6 and VCP/p97
Sequence caution: Sequence=CAD62329.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B7ZLA3 B7ZLA4 Q2M2X3 Q86T12Alternative splicing: 5 isoforms: Q9H867-4 Q9H867-1 Q9H867-2 Q9H867-3 Q9H867-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for METTL21D: NX_Q9H867
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H867
METTL21D Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001035752.1 NP_078834.2
ENSEMBL proteins: ENSP00000379201 ENSP00000437113 ENSP00000379200
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
METTL21D for ontologies About GeneDecksing
METTL21D Antibody Products:
Assay Products for METTL21D: |
Protein
Domains /
Families
for METTL21D gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
METTL21D for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9H867ProtoNet protein and cluster: Q9H867 UniProtKB/Swiss-Prot: MT21D_HUMAN, Q9H867Similarity: Belongs to the methyltransferase superfamily. METTL21 family |
Function
for METTL21D gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MT21D_HUMAN, Q9H867Function: Protein-lysine N-methyltransferase that specifically trimethylates 'Lys-315' of VCP/p97Enzyme Number (IUBMB): EC 2.1.1.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL21D (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL21D (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): METTL21D (NM_024558) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for METTL21D | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL21D |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL21D |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
-- | -- | | GO:0005515 | protein binding |
IPI | -- | | GO:0008168 | methyltransferase activity |
-- | -- | | GO:0016279 | protein-lysine N-methyltransferase activity |
IDA | -- |
METTL21D for ontologies About GeneDecksing
|
Pathways & Interactions
for METTL21D gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for METTL21D
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
-- | -- | | GO:0018023 | peptidyl-lysine trimethylation |
IDA | -- |
METTL21D for ontologies About GeneDecksing
|
Drugs & Compounds
for METTL21D gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for METTL21D
Search CenterWatch for drugs/clinical trials and news about METTL21D / MT21D
|
Transcripts
for METTL21D gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for METTL21D gene (2 alternative transcripts): NM_001040662.1 NM_024558.2 Unigene Cluster for METTL21D: Methyltransferase like 21D Hs.558541 [show with all ESTs]Unigene Representative Sequence: NR_0497395 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000569518(uc001wxn.1) ENST00000395860 ENST00000491402(uc001wxo.1 uc001wxp.1 uc001wxq.1)
ENST00000484763 ENST00000395859
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL21D (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL21D (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): METTL21D (NM_024558) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for METTL21D | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL21D |
Additional cDNA sequence: AK129564.1 BC027585.2 BC143673.1 BC143674.1 BX247997.1 NR_049738.1 NR_049739.1 11 DOTS entries: DT.315010 DT.100785311 DT.100753471 DT.102825940 DT.100799045 DT.75100067 DT.100785312 DT.91737719 DT.315011 DT.120759075 DT.100809781 24/289 AceView cDNA sequences (see all 289): AA713679 BG286823 BM263987 AL135612 AW518885 BG617243 AI272033 CK818831 CR597030 AA374200 CR601939 AA256588 AA633530 BI758040 AI783684 BQ023936 N54093 AI419975 BX247997 AA262031 AI003776 N54196 AL705140 BM127111
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for METTL21D (see all 8) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d |
|---|
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| SP1: | | | | | - | | | | - | | - | | | | | | | | - | | - | | | | - | | | | | | | | | | |
| SP2: | | | | | - | | | | | | - | | | | | | | | - | | - | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | | | - | | - | | | | - | | | | | | | | | | |
| SP4: | | | | | - | | | | | | - | | | | | | | | - | | - | | - | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | | | - | | | | - | | - | | | | | | | | | |
ECgene alternative splicing isoforms for METTL21D
|
Expression
for METTL21D gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| METTL21D expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGCAGTGAA
About this image
See METTL21D Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for METTL21D
SOURCE GeneReport for Unigene cluster: Hs.558541
SABiosciences Custom PCR Arrays for METTL21D
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for METTL21D
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat METTL21D | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL21D | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL21D | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL21D |
Orthologs
for METTL21D gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for METTL21D gene from 8/17 species (see all 17) About this table
ENSEMBL Gene Tree for METTL21D (if available)
TreeFam Gene Tree for METTL21D (if available) |
Paralogs
for METTL21D gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for METTL21D gene
- METTL21B2 METTL21C2 METTL21A2
1 SIMAP similar gene for METTL21D using alignment to 1 protein entry: MT21D_HUMAN:METTL21A
METTL21D for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for METTL21D
PGOHUM00000243970
|
Genomic Variants
for METTL21D gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for METTL21D (50575350 - 50583318 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for METTL21D: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing METTL21D |
|
Disorders
/ Diseases
for METTL21D gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for METTL21D gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for METTL21D gene integrated from 9 sources:
(articles sorted by number of sources associating them with METTL21D) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Lysine methylation of VCP by a member of a novel human protein methyltransferase family. (PubMed id 22948820)1, 2 Kernstock S.... Falnes P.O. (2012)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for METTL21D gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing METTL21D gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing METTL21D gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing METTL21D gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for METTL21D | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for METTL21D gene:
Search GeneIP for patents involving METTL21D
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for METTL21D gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for METTL21D | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for METTL21D | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for METTL21D | | | OriGene Protein Over-expression Lysate for METTL21D | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for METTL21D | | OriGene 3'-UTR Clone for METTL21D | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL21D | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL21D | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for METTL21D | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for METTL21D | | OriGene Custom Protein Services for METTL21D | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat METTL21D | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing METTL21D | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL21D | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat METTL21D | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL21D | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL21D |
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 | | | METTL21D Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL21D |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL21D |
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