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Aliases for METTL21C Gene

Aliases for METTL21C Gene

  • Methyltransferase Like 21C 2 3 5
  • Methyltransferase-Like Protein 21C 3 4
  • C13orf39 3 4
  • Protein-Lysine Methyltransferase METTL21C 3
  • Chromosome 13 Open Reading Frame 39 2
  • EC 2.1.1.- 4

External Ids for METTL21C Gene

Previous HGNC Symbols for METTL21C Gene

  • C13orf39

Previous GeneCards Identifiers for METTL21C Gene

  • GC13M103339

Summaries for METTL21C Gene

GeneCards Summary for METTL21C Gene

METTL21C (Methyltransferase Like 21C) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein-lysine N-methyltransferase activity. An important paralog of this gene is METTL21A.

UniProtKB/Swiss-Prot for METTL21C Gene

  • Protein-lysine methyltransferase.

Additional gene information for METTL21C Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL21C Gene

Genomics for METTL21C Gene

GeneHancer (GH) Regulatory Elements for METTL21C Gene

Promoters and enhancers for METTL21C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I102694 Promoter 0.5 EPDnew 550.8 -0.1 -72 0.1 METTL21C LINC00283
GH13I102844 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.9 -152.0 -151979 3.9 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ERCC5 BIVM TEX30 METTL21EP TPP2 CCDC168 LINC00283 METTL21C GC13P102835 GC13M102871
GH13I102594 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 7.9 +97.2 97203 5.2 PKNOX1 SMAD1 FOXA2 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TPP2 ERCC5 METTL21C GC13P102663
GH13I102729 Enhancer 0.9 Ensembl ENCODE 10.8 -35.4 -35415 1.5 STAT1 NFIB JUN BHLHE40 BATF EP300 ZNF335 JUND NFIC GATA3 METTL21C LINC00283 CCDC168
GH13I102825 Enhancer 1 Ensembl ENCODE dbSUPER 9.7 -131.7 -131722 2 JUN CEBPB EP300 RAD21 RFX5 JUND STAT3 SMC3 FOS CCDC168 LINC00283 METTL21C ENSG00000272542 METTL21EP GC13P102835 RNY5P8 BIVM-ERCC5 BIVM
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around METTL21C on UCSC Golden Path with GeneCards custom track

Genomic Locations for METTL21C Gene

Genomic Locations for METTL21C Gene
8,778 bases
Minus strand

Genomic View for METTL21C Gene

Genes around METTL21C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL21C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL21C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL21C Gene

Proteins for METTL21C Gene

  • Protein details for METTL21C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein-lysine methyltransferase METTL21C
    Protein Accession:

    Protein attributes for METTL21C Gene

    264 amino acids
    Molecular mass:
    29565 Da
    Quaternary structure:
    • Interacts with members of the heat shock protein 70 families; these proteins may possibly be methylation substrates for the enzyme.

    Three dimensional structures from OCA and Proteopedia for METTL21C Gene

neXtProt entry for METTL21C Gene

Post-translational modifications for METTL21C Gene

No Post-translational modifications

Other Protein References for METTL21C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for METTL21C Gene

Domains & Families for METTL21C Gene

Gene Families for METTL21C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for METTL21C Gene

Suggested Antigen Peptide Sequences for METTL21C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the methyltransferase superfamily. METTL21 family.
  • Belongs to the methyltransferase superfamily. METTL21 family.
genes like me logo Genes that share domains with METTL21C: view

Function for METTL21C Gene

Molecular function for METTL21C Gene

UniProtKB/Swiss-Prot Function:
Protein-lysine methyltransferase.

Enzyme Numbers (IUBMB) for METTL21C Gene

Phenotypes From GWAS Catalog for METTL21C Gene

Gene Ontology (GO) - Molecular Function for METTL21C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008168 methyltransferase activity IEA --
GO:0016279 protein-lysine N-methyltransferase activity IDA 22948820
GO:0016740 transferase activity IEA --
GO:0031072 heat shock protein binding IPI 23349634
genes like me logo Genes that share ontologies with METTL21C: view
genes like me logo Genes that share phenotypes with METTL21C: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for METTL21C Gene

Localization for METTL21C Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL21C Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL21C gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for METTL21C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 23349634
GO:0043234 protein complex IDA 23349634
genes like me logo Genes that share ontologies with METTL21C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for METTL21C Gene

Pathways & Interactions for METTL21C Gene

SuperPathways for METTL21C Gene

No Data Available

Gene Ontology (GO) - Biological Process for METTL21C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006479 protein methylation IDA 22948820
GO:0007519 skeletal muscle tissue development IEA --
GO:0008628 hormone-mediated apoptotic signaling pathway IEA --
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IEA --
GO:0018022 peptidyl-lysine methylation IEA --
genes like me logo Genes that share ontologies with METTL21C: view

No data available for Pathways by source and SIGNOR curated interactions for METTL21C Gene

Drugs & Compounds for METTL21C Gene

No Compound Related Data Available

Transcripts for METTL21C Gene

mRNA/cDNA for METTL21C Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(24) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for METTL21C Gene

Methyltransferase like 21C:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL21C Gene

No ASD Table

Relevant External Links for METTL21C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL21C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for METTL21C Gene

mRNA differential expression in normal tissues according to GTEx for METTL21C Gene

This gene is overexpressed in Muscle - Skeletal (x16.2), Brain - Frontal Cortex (BA9) (x9.6), Brain - Cortex (x7.5), and Brain - Anterior cingulate cortex (BA24) (x5.1).

NURSA nuclear receptor signaling pathways regulating expression of METTL21C Gene:


SOURCE GeneReport for Unigene cluster for METTL21C Gene:

genes like me logo Genes that share expression patterns with METTL21C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL21C Gene

Orthologs for METTL21C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for METTL21C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia METTL21C 33 34
  • 99.12 (n)
(Canis familiaris)
Mammalia METTL21C 33 34
  • 85.86 (n)
(Mus musculus)
Mammalia Mettl21c 33 16 34
  • 83.48 (n)
(Rattus norvegicus)
Mammalia Mettl21c 33
  • 82.66 (n)
(Bos Taurus)
Mammalia METTL21C 33 34
  • 82.36 (n)
(Ornithorhynchus anatinus)
Mammalia METTL21C 34
  • 74 (a)
(Monodelphis domestica)
Mammalia METTL21C 34
  • 64 (a)
(Gallus gallus)
Aves METTL21C 33 34
  • 66.21 (n)
(Anolis carolinensis)
Reptilia METTL21C 34
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl21c 33
  • 64.45 (n)
(Danio rerio)
Actinopterygii LOC100149425 33
  • 57.71 (n)
METTL21C (1 of 2) 34
  • 44 (a)
METTL21C (2 of 2) 34
  • 13 (a)
(Caenorhabditis elegans)
Secernentea C42C1.13 34
  • 24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 27 (a)
NNT1 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 25 (a)
Species where no ortholog for METTL21C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL21C Gene

Gene Tree for METTL21C (if available)
Gene Tree for METTL21C (if available)

Paralogs for METTL21C Gene

Paralogs for METTL21C Gene

(1) SIMAP similar genes for METTL21C Gene using alignment to 1 proteins: Pseudogenes for METTL21C Gene

genes like me logo Genes that share paralogs with METTL21C: view

Variants for METTL21C Gene

Sequence variations from dbSNP and Humsavar for METTL21C Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000010905 -- 102,704,891(-) T/C upstream_transcript_variant
rs1000281160 -- 102,700,132(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000600457 -- 102,690,805(-) T/A intron_variant
rs1000728480 -- 102,696,032(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000889512 -- 102,701,234(-) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for METTL21C Gene

Variant ID Type Subtype PubMed ID
esv1001430 CNV insertion 20482838
esv3310493 CNV novel sequence insertion 20981092
esv3330097 CNV duplication 20981092
esv3348023 CNV duplication 20981092
esv3386709 CNV duplication 20981092
esv3393502 CNV insertion 20981092
esv3580867 CNV loss 25503493
nsv1157 CNV insertion 18451855
nsv519661 CNV loss 19592680

Variation tolerance for METTL21C Gene

Residual Variation Intolerance Score: 85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.28; 40.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for METTL21C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL21C Gene

Disorders for METTL21C Gene

Additional Disease Information for METTL21C

No disorders were found for METTL21C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL21C Gene

Publications for METTL21C Gene

  1. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P … Coulombe B (PLoS genetics 2013) 3 4 58
  2. Lysine methylation of VCP by a member of a novel human protein methyltransferase family. (PMID: 22948820) Kernstock S … Falnes PØ (Nature communications 2012) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for METTL21C Gene

Sources for METTL21C Gene

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