Free for academic non-profit institutions. Other users need a Commercial license

Aliases for METTL21C Gene

Aliases for METTL21C Gene

  • Methyltransferase Like 21C 2 3
  • C13orf39 3 4 6
  • Methyltransferase-Like Protein 21C 3 4
  • Protein-Lysine Methyltransferase METTL21C 3
  • Chromosome 13 Open Reading Frame 39 2
  • EC 2.1.1.- 4

External Ids for METTL21C Gene

Previous HGNC Symbols for METTL21C Gene

  • C13orf39

Previous GeneCards Identifiers for METTL21C Gene

  • GC13M103339

Summaries for METTL21C Gene

GeneCards Summary for METTL21C Gene

METTL21C (Methyltransferase Like 21C) is a Protein Coding gene. GO annotations related to this gene include protein-lysine N-methyltransferase activity. An important paralog of this gene is VCPKMT.

UniProtKB/Swiss-Prot for METTL21C Gene

  • Protein-lysine methyltransferase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL21C Gene

Genomics for METTL21C Gene

Genomic Location for METTL21C Gene

102,685,744 bp from pter
102,694,521 bp from pter
8,778 bases
Minus strand

Genomic View for METTL21C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for METTL21C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL21C Gene

No data available for Regulatory Elements for METTL21C Gene

Proteins for METTL21C Gene

  • Protein details for METTL21C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein-lysine methyltransferase METTL21C
    Protein Accession:
    Secondary Accessions:

    Protein attributes for METTL21C Gene

    264 amino acids
    Molecular mass:
    29565 Da
    Quaternary structure:
    • Interacts with members of the heat shock protein 70 families; these proteins may possibly be methylation substrates for the enzyme.

    Three dimensional structures from OCA and Proteopedia for METTL21C Gene

neXtProt entry for METTL21C Gene

Proteomics data for METTL21C Gene at MOPED

Post-translational modifications for METTL21C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for METTL21C Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for METTL21C Gene

Domains for METTL21C Gene

Protein Domains for METTL21C Gene

Suggested Antigen Peptide Sequences for METTL21C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q5VZV1
  • Belongs to the methyltransferase superfamily. METTL21 family.
genes like me logo Genes that share domains with METTL21C: view

No data available for Gene Families for METTL21C Gene

Function for METTL21C Gene

Molecular function for METTL21C Gene

UniProtKB/Swiss-Prot Function:
Protein-lysine methyltransferase.

Enzyme Numbers (IUBMB) for METTL21C Gene

Gene Ontology (GO) - Molecular Function for METTL21C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016279 protein-lysine N-methyltransferase activity IDA 22948820
genes like me logo Genes that share ontologies with METTL21C: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for METTL21C

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for METTL21C Gene

Localization for METTL21C Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL21C Gene

Gene Ontology (GO) - Cellular Components for METTL21C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with METTL21C: view

No data available for Subcellular locations from COMPARTMENTS for METTL21C Gene

Pathways for METTL21C Gene

SuperPathways for METTL21C Gene

No Data Available

Gene Ontology (GO) - Biological Process for METTL21C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006479 protein methylation IDA 22948820
GO:0018022 peptidyl-lysine methylation IDA 22948820
genes like me logo Genes that share ontologies with METTL21C: view

No data available for Pathways by source for METTL21C Gene

Transcripts for METTL21C Gene

mRNA/cDNA for METTL21C Gene

(24) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for METTL21C Gene

Methyltransferase like 21C:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for METTL21C

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL21C Gene

No ASD Table

Relevant External Links for METTL21C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL21C Gene

mRNA expression in normal human tissues for METTL21C Gene

mRNA differential expression in normal tissues according to GTEx for METTL21C Gene

This gene is overexpressed in Muscle - Skeletal (16.2), Brain - Frontal Cortex (BA9) (9.6), Brain - Cortex (7.5), and Brain - Anterior cingulate cortex (BA24) (5.1).

SOURCE GeneReport for Unigene cluster for METTL21C Gene Hs.508623

genes like me logo Genes that share expressions with METTL21C: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for METTL21C Gene

Orthologs for METTL21C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for METTL21C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia METTL21C 35
  • 82.36 (n)
  • 82.1 (a)
  • 82 (a)
(Canis familiaris)
Mammalia METTL21C 35
  • 85.86 (n)
  • 84.09 (a)
  • 84 (a)
(Mus musculus)
Mammalia Mettl21c 35
  • 83.48 (n)
  • 82.05 (a)
Mettl21c 16
Mettl21c 36
  • 80 (a)
(Pan troglodytes)
Mammalia METTL21C 35
  • 99.12 (n)
  • 99.24 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Mettl21c 35
  • 82.66 (n)
  • 83.47 (a)
(Monodelphis domestica)
Mammalia METTL21C 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia METTL21C 36
  • 74 (a)
(Gallus gallus)
Aves METTL21C 35
  • 66.21 (n)
  • 64.22 (a)
  • 57 (a)
(Anolis carolinensis)
Reptilia METTL21C 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl21c 35
  • 64.45 (n)
  • 60.19 (a)
(Danio rerio)
Actinopterygii LOC100149425 35
  • 57.71 (n)
  • 54.23 (a)
METTL21C (1 of 2) 36
  • 44 (a)
METTL21C (2 of 2) 36
  • 13 (a)
(Caenorhabditis elegans)
Secernentea C42C1.13 36
  • 24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 27 (a)
NNT1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
Species with no ortholog for METTL21C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL21C Gene

Gene Tree for METTL21C (if available)
Gene Tree for METTL21C (if available)

Paralogs for METTL21C Gene

Paralogs for METTL21C Gene

Selected SIMAP similar genes for METTL21C Gene using alignment to 1 proteins: Pseudogenes for METTL21C Gene

genes like me logo Genes that share paralogs with METTL21C: view

Variants for METTL21C Gene

Sequence variations from dbSNP and Humsavar for METTL21C Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs1587 -- 102,685,880(+) TAGAA(A/C)GTTTC utr-variant-3-prime
rs595825 -- 102,689,762(+) GCCTG(C/T)GTTCC intron-variant
rs599976 -- 102,695,866(-) TGTAC(C/T)GATGA upstream-variant-2KB
rs612900 -- 102,695,268(+) GGGAC(A/G)GGAGT upstream-variant-2KB
rs612938 -- 102,695,241(+) AGAAA(G/T)GAGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for METTL21C Gene

Variant ID Type Subtype PubMed ID
nsv1157 CNV Insertion 18451855
nsv519661 CNV Loss 19592680
esv1001430 CNV Insertion 20482838

Relevant External Links for METTL21C Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL21C Gene

Disorders for METTL21C Gene

No disorders were found for METTL21C Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for METTL21C Gene

Publications for METTL21C Gene

  1. Lysine methylation of VCP by a member of a novel human protein methyltransferase family. (PMID: 22948820) Kernstock S. … Falnes P.O. (Nat. Commun. 2012) 3 4
  2. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P. … Coulombe B. (PLoS Genet. 2013) 3 4
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for METTL21C Gene

Sources for METTL21C Gene

Back to Top