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Aliases for METTL21B Gene

Aliases for METTL21B Gene

  • Methyltransferase Like 21B 2 3
  • FAM119B 3 4 6
  • Hepatocellular Carcinoma-Associated Antigen 557a 3 4
  • Family With Sequence Similarity 119, Member B 2 3
  • Methyltransferase-Like Protein 21B 3 4
  • Hepatocellularcarcinoma-Associated Antigen HCA557a 3
  • Protein-Lysine Methyltransferase METTL21B 3
  • EC 2.1.1.- 4
  • HCA557A 4

External Ids for METTL21B Gene

Previous Symbols for METTL21B Gene

  • FAM119B

Summaries for METTL21B Gene

GeneCards Summary for METTL21B Gene

METTL21B (Methyltransferase Like 21B) is a Protein Coding gene. Diseases associated with METTL21B include hepatocellular carcinoma. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is VCPKMT.

UniProtKB/Swiss-Prot for METTL21B Gene

  • Protein-lysine methyltransferase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL21B Gene

Genomics for METTL21B Gene

Genomic Location for METTL21B Gene

Start:
57,771,492 bp from pter
End:
57,782,541 bp from pter
Size:
11,050 bases
Orientation:
Plus strand

Genomic View for METTL21B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for METTL21B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL21B Gene

No data available for Regulatory Elements for METTL21B Gene

Proteins for METTL21B Gene

  • Protein details for METTL21B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AZ1-MT21B_HUMAN
    Recommended name:
    Protein-lysine methyltransferase METTL21B
    Protein Accession:
    Q96AZ1
    Secondary Accessions:
    • Q9H749
    • Q9Y3W2

    Protein attributes for METTL21B Gene

    Size:
    226 amino acids
    Molecular mass:
    24911 Da
    Quaternary structure:
    • Interacts with members of the heat shock protein 70 and 90 families and of the TCP-1 chaperonin family, as well as with HSPD1, STIP1 and tubulin; at least some of these proteins may be methylation substrates.

    Three dimensional structures from OCA and Proteopedia for METTL21B Gene

    Alternative splice isoforms for METTL21B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for METTL21B Gene

Proteomics data for METTL21B Gene at MOPED

Post-translational modifications for METTL21B Gene

No Post-translational modifications

Other Protein References for METTL21B Gene

No data available for DME Specific Peptides for METTL21B Gene

Domains for METTL21B Gene

Protein Domains for METTL21B Gene

UniProtKB/Swiss-Prot:

MT21B_HUMAN
Family:
  • Belongs to the methyltransferase superfamily. METTL21 family.:
    • Q96AZ1
genes like me logo Genes that share domains with METTL21B: view

No data available for Gene Families for METTL21B Gene

Function for METTL21B Gene

Molecular function for METTL21B Gene

UniProtKB/Swiss-Prot Function: Protein-lysine methyltransferase.

Enzyme Numbers (IUBMB) for METTL21B Gene

Gene Ontology (GO) - Molecular Function for METTL21B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with METTL21B: view

Phenotypes for METTL21B Gene

GenomeRNAi human phenotypes for METTL21B:
genes like me logo Genes that share phenotypes with METTL21B: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for METTL21B Gene

Localization for METTL21B Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL21B Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for METTL21B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with METTL21B: view

Pathways for METTL21B Gene

SuperPathways for METTL21B Gene

No Data Available

Interacting Proteins for METTL21B Gene

Gene Ontology (GO) - Biological Process for METTL21B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL21B: view

No data available for Pathways by source for METTL21B Gene

Transcripts for METTL21B Gene

Unigene Clusters for METTL21B Gene

Methyltransferase like 21B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for METTL21B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1: - -
SP2: - -
SP3: -

Relevant External Links for METTL21B Gene

GeneLoc Exon Structure for
METTL21B
ECgene alternative splicing isoforms for
METTL21B

Expression for METTL21B Gene

mRNA expression in normal human tissues for METTL21B Gene

mRNA differential expression in normal tissues according to GTEx for METTL21B Gene

This gene is overexpressed in Pancreas (4.1).

SOURCE GeneReport for Unigene cluster for METTL21B Gene Hs.632720

genes like me logo Genes that share expressions with METTL21B: view

Orthologs for METTL21B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for METTL21B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL21B 36
  • 99.41 (n)
  • 99.56 (a)
METTL21B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia METTL21B 36
  • 92.04 (n)
  • 92.04 (a)
METTL21B 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia METTL21B 36
  • 93 (n)
  • 95.58 (a)
METTL21B 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia LOC100504608 36
  • 86.28 (n)
  • 84.96 (a)
Mettl21b 16
Mettl21b 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia METTL21B 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia METTL21B 37
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC679247 36
  • 86.64 (n)
  • 87.39 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 30 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia METTL21B 37
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl21b 36
  • 61.62 (n)
  • 60.55 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:92518 37
  • 34 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C42C1.13 37
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 28 (a)
OneToMany
-- 39
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 32 (a)
OneToMany
Species with no ortholog for METTL21B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL21B Gene

ENSEMBL:
Gene Tree for METTL21B (if available)
TreeFam:
Gene Tree for METTL21B (if available)

Paralogs for METTL21B Gene

Paralogs for METTL21B Gene

Selected SIMAP similar genes for METTL21B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with METTL21B: view

Variants for METTL21B Gene

Sequence variations from dbSNP and Humsavar for METTL21B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs923829 -- 57,780,523(-) GTCCC(A/G)TGCTC synonymous-codon, reference, utr-variant-3-prime
rs4760323 -- 57,776,119(+) aatct(A/T)tcagt intron-variant
rs4760324 -- 57,776,387(+) cctcc(C/T)tggca intron-variant
rs7302483 -- 57,778,010(+) gcgag(A/C)ctcca intron-variant
rs7316109 -- 57,774,282(+) ttgag(A/G)ccagc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for METTL21B Gene

Variant ID Type Subtype PubMed ID
nsv899121 CNV Loss 21882294
nsv470296 CNV Loss 18288195
nsv510601 CNV Loss 20534489
nsv470297 CNV Gain 18288195

Relevant External Links for METTL21B Gene

HapMap Linkage Disequilibrium report
METTL21B

Disorders for METTL21B Gene

(1) MalaCards Diseases for METTL21B Gene

Search for METTL21B Gene in MalaCards »
genes like me logo Genes that share disorders with METTL21B: view

No data available for UniProtKB/Swiss-Prot for METTL21B Gene

Publications for METTL21B Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P. … Coulombe B. (PLoS Genet. 2013) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4

Products for METTL21B Gene

  • antibodies-online proteins for METTL21B
  • antibodies-online antibodies for METTL21B
  • antibodies-online kits for METTL21B

Sources for METTL21B Gene

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