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Aliases for METTL21B Gene

Aliases for METTL21B Gene

  • Methyltransferase Like 21B 2 3 5
  • Hepatocellular Carcinoma-Associated Antigen 557a 3 4
  • Family With Sequence Similarity 119, Member B 2 3
  • Methyltransferase-Like Protein 21B 3 4
  • FAM119B 3 4
  • Hepatocellularcarcinoma-Associated Antigen HCA557a 3
  • Protein-Lysine Methyltransferase METTL21B 3
  • EC 2.1.1.- 4
  • HCA557A 4

External Ids for METTL21B Gene

Previous HGNC Symbols for METTL21B Gene

  • FAM119B

Previous GeneCards Identifiers for METTL21B Gene

  • GC12P058168
  • GC12P058165

Summaries for METTL21B Gene

GeneCards Summary for METTL21B Gene

METTL21B (Methyltransferase Like 21B) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is METTL21A.

UniProtKB/Swiss-Prot for METTL21B Gene

  • Protein-lysine methyltransferase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL21B Gene

Genomics for METTL21B Gene

Regulatory Elements for METTL21B Gene

Enhancers for METTL21B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F057770 0.2 ENCODE 50 +0.6 636 3.0 HDGF CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF302 TSFM METTL21B NEMP1 LOC283387 ZBTB39 TSPAN31 CTDSP2 ENSG00000224713 METTL1
GH12F057780 0.2 ENCODE 49.8 +9.6 9627 1.4 GTF2E2 TSFM METTL21B ENSG00000257921
GH12F057850 0.9 Ensembl ENCODE 37.4 +80.7 80709 3.6 CTCF USF1 ZNF133 ZNF223 MAX RAD21 ZNF664 ZNF316 PRDM10 NFE2 TSFM METTL21B MIR26A2 RNU6-1083P CYP27B1 METTL1 CTDSP2 LOC102724211
GH12F057830 1.1 FANTOM5 ENCODE 35.3 +68.0 67988 17.0 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 METTL21B TSFM ATP23 METTL1 CTDSP2 TSPAN31 CDK4 AGAP2 LOC283387 PIR34053
GH12F057868 1.7 FANTOM5 Ensembl ENCODE 33.6 +97.9 97875 2.0 PKNOX1 SMARCA4 POLR2A SCRT2 KLF17 ZBTB8A FOXP2 METTL21B AVIL CTDSP2 MIR26A2 TSFM METTL1 CYP27B1 RNU6-1083P CDK4 MARCH9
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around METTL21B on UCSC Golden Path with GeneCards custom track

Promoters for METTL21B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000431450 908 2401 HDGF CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF302

Genomic Location for METTL21B Gene

Chromosome:
12
Start:
57,771,492 bp from pter
End:
57,782,541 bp from pter
Size:
11,050 bases
Orientation:
Plus strand

Genomic View for METTL21B Gene

Genes around METTL21B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL21B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL21B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL21B Gene

Proteins for METTL21B Gene

  • Protein details for METTL21B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AZ1-MT21B_HUMAN
    Recommended name:
    Protein-lysine methyltransferase METTL21B
    Protein Accession:
    Q96AZ1
    Secondary Accessions:
    • Q9H749
    • Q9Y3W2

    Protein attributes for METTL21B Gene

    Size:
    226 amino acids
    Molecular mass:
    24911 Da
    Quaternary structure:
    • Interacts with members of the heat shock protein 70 and 90 families and of the TCP-1 chaperonin family, as well as with HSPD1, STIP1 and tubulin; at least some of these proteins may be methylation substrates.

    Three dimensional structures from OCA and Proteopedia for METTL21B Gene

    Alternative splice isoforms for METTL21B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for METTL21B Gene

Post-translational modifications for METTL21B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for METTL21B Gene

No data available for DME Specific Peptides for METTL21B Gene

Domains & Families for METTL21B Gene

Gene Families for METTL21B Gene

Protein Domains for METTL21B Gene

Suggested Antigen Peptide Sequences for METTL21B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96AZ1

UniProtKB/Swiss-Prot:

MT21B_HUMAN :
  • Belongs to the methyltransferase superfamily. METTL21 family.
Family:
  • Belongs to the methyltransferase superfamily. METTL21 family.
genes like me logo Genes that share domains with METTL21B: view

Function for METTL21B Gene

Molecular function for METTL21B Gene

UniProtKB/Swiss-Prot Function:
Protein-lysine methyltransferase.

Enzyme Numbers (IUBMB) for METTL21B Gene

Gene Ontology (GO) - Molecular Function for METTL21B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with METTL21B: view
genes like me logo Genes that share phenotypes with METTL21B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for METTL21B Gene

Localization for METTL21B Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL21B Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for METTL21B Gene COMPARTMENTS Subcellular localization image for METTL21B gene
Compartment Confidence
nucleus 3
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for METTL21B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with METTL21B: view

Pathways & Interactions for METTL21B Gene

SuperPathways for METTL21B Gene

No Data Available

Gene Ontology (GO) - Biological Process for METTL21B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL21B: view

No data available for Pathways by source and SIGNOR curated interactions for METTL21B Gene

Transcripts for METTL21B Gene

Unigene Clusters for METTL21B Gene

Methyltransferase like 21B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL21B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1: - -
SP2: - -
SP3: -

Relevant External Links for METTL21B Gene

GeneLoc Exon Structure for
METTL21B
ECgene alternative splicing isoforms for
METTL21B

Expression for METTL21B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for METTL21B Gene

mRNA differential expression in normal tissues according to GTEx for METTL21B Gene

This gene is overexpressed in Pancreas (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of METTL21B Gene:

METTL21B

SOURCE GeneReport for Unigene cluster for METTL21B Gene:

Hs.632720
genes like me logo Genes that share expression patterns with METTL21B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for METTL21B Gene

Orthologs for METTL21B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for METTL21B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL21B 34 35
  • 99.41 (n)
dog
(Canis familiaris)
Mammalia METTL21B 34 35
  • 93 (n)
cow
(Bos Taurus)
Mammalia METTL21B 34 35
  • 92.04 (n)
rat
(Rattus norvegicus)
Mammalia LOC679247 34
  • 86.64 (n)
mouse
(Mus musculus)
Mammalia LOC100504608 34
  • 86.28 (n)
Mettl21b 16 35
  • 83 (a)
oppossum
(Monodelphis domestica)
Mammalia METTL21B 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia METTL21B 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 30 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia METTL21B 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl21b 34
  • 61.62 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:92518 35
  • 34 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C42C1.13 35
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 28 (a)
OneToMany
EFM2 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 32 (a)
OneToMany
Species where no ortholog for METTL21B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL21B Gene

ENSEMBL:
Gene Tree for METTL21B (if available)
TreeFam:
Gene Tree for METTL21B (if available)

Paralogs for METTL21B Gene

Paralogs for METTL21B Gene

(2) SIMAP similar genes for METTL21B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with METTL21B: view

Variants for METTL21B Gene

Sequence variations from dbSNP and Humsavar for METTL21B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs587777689 Pathogenic 57,782,862(+) CGGTG(A/G)GAAGT intron-variant, downstream-variant-500B
rs869025542 Uncertain significance 57,782,803(+) AGAGA(G/T)GTCGC downstream-variant-500B, reference, missense
rs138461986 Benign 57,782,825(+) CTGCG(C/T)GTGTT downstream-variant-500B, reference, synonymous-codon
rs10747783 -- 57,782,831(+) GTGTT(C/T)CTGGT downstream-variant-500B, reference, synonymous-codon
rs10783846 -- 57,774,802(+) GCAGG(C/T)TCAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for METTL21B Gene

Variant ID Type Subtype PubMed ID
nsv470296 CNV loss 18288195
nsv470297 CNV gain 18288195
nsv510601 CNV deletion 20534489
nsv559046 CNV gain 21841781

Variation tolerance for METTL21B Gene

Residual Variation Intolerance Score: 49.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for METTL21B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
METTL21B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL21B Gene

Disorders for METTL21B Gene

Relevant External Links for METTL21B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
METTL21B

No disorders were found for METTL21B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL21B Gene

Publications for METTL21B Gene

  1. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P. … Coulombe B. (PLoS Genet. 2013) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Lysine methylation of VCP by a member of a novel human protein methyltransferase family. (PMID: 22948820) Kernstock S. … Falnes P.O. (Nat. Commun. 2012) 3 64
  4. The multiple sclerosis whole blood mRNA transcriptome and genetic associations indicate dysregulation of specific T cell pathways in pathogenesis. (PMID: 20190274) Gandhi K.S. … Booth D.R. (Hum. Mol. Genet. 2010) 3 64
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64

Products for METTL21B Gene

Sources for METTL21B Gene

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