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Aliases for METTL21A Gene

Aliases for METTL21A Gene

  • Methyltransferase Like 21A 2 3 5
  • Hepatocellular Carcinoma-Associated Antigen 557b 2 3 4
  • Heat Shock Protein 70kDa Lysine (K) Methyltransferase 2 3
  • Family With Sequence Similarity 119, Member A 2 3
  • Methyltransferase-Like Protein 21A 3 4
  • HSPA Lysine Methyltransferase 3 4
  • HSPA-KMT 3 4
  • HCA557b 3 4
  • FAM119A 3 4
  • Protein N-Lysine Methyltransferase METTL21A 3
  • EC 2.1.1.- 4

External Ids for METTL21A Gene

Previous HGNC Symbols for METTL21A Gene

  • FAM119A

Previous GeneCards Identifiers for METTL21A Gene

  • GC02M208446

Summaries for METTL21A Gene

GeneCards Summary for METTL21A Gene

METTL21A (Methyltransferase Like 21A) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Protein methylation. GO annotations related to this gene include methyltransferase activity and Hsp70 protein binding. An important paralog of this gene is EEF1AKMT3.

UniProtKB/Swiss-Prot for METTL21A Gene

  • Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates Lys-561 in HSPA1, Lys-564 in HSPA2, Lys-585 in HSPA5, Lys-563 in HSPA6 and Lys-561 in HSPA8.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL21A Gene

Genomics for METTL21A Gene

Regulatory Elements for METTL21A Gene

Enhancers for METTL21A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G207526 1.8 FANTOM5 ENCODE dbSUPER 34.2 +94.8 94781 8.9 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 METTL21A CREB1 KLF7-IT1 ENSG00000223725 RNU6-664P PPP1R14BP2 ENSG00000200764 PLEKHM3 GC02P207602
GH02G207501 1.8 FANTOM5 Ensembl ENCODE dbSUPER 29.5 +121.4 121424 5.4 ATF1 FOXA2 PKNOX1 YY1 TCF12 GATA2 FOS TBX21 ZNF592 SMARCA4 METTL21A CREB1 ENSG00000223725 GC02P207503 GC02M207504
GH02G207512 1.5 FANTOM5 Ensembl ENCODE dbSUPER 29.7 +111.4 111367 4.4 ZNF263 PKNOX1 BHLHE40 SIN3A ZNF407 JUND GATA2 PBX2 FOS FOXJ2 METTL21A CREB1 GC02M207504
GH02G207615 1.7 FANTOM5 Ensembl ENCODE dbSUPER 23.3 +7.4 7437 5.4 HDGF PKNOX1 FOXA2 ZFP64 ARID4B GATA2 FOS NFYC PPARG TBX21 METTL21A CCNYL1 CREB1 PLEKHM3 GC02P207602
GH02G207556 0.9 ENCODE dbSUPER 34.1 +68.3 68305 2.1 TEAD1 CEBPB CEBPG EP300 TEAD3 CTBP1 GATA3 CEBPA PRDM1 METTL21A ENSG00000223725 CREB1 GC02P207602
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around METTL21A on UCSC Golden Path with GeneCards custom track

Promoters for METTL21A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000129480 428 3001 PKNOX1 MLX CREB3L1 ARNT AGO1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1

Genomic Location for METTL21A Gene

Chromosome:
2
Start:
207,580,631 bp from pter
End:
207,625,928 bp from pter
Size:
45,298 bases
Orientation:
Minus strand

Genomic View for METTL21A Gene

Genes around METTL21A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL21A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL21A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL21A Gene

Proteins for METTL21A Gene

  • Protein details for METTL21A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXB1-MT21A_HUMAN
    Recommended name:
    Protein N-lysine methyltransferase METTL21A
    Protein Accession:
    Q8WXB1
    Secondary Accessions:
    • Q53RV0
    • Q8N1Z9
    • Q96GH6

    Protein attributes for METTL21A Gene

    Size:
    218 amino acids
    Molecular mass:
    24600 Da
    Quaternary structure:
    • Interacts with heat shock protein 70 family members; at least some of these proteins are methylation substrates (PubMed:23349634 and PubMed:23921388).

    Three dimensional structures from OCA and Proteopedia for METTL21A Gene

    Alternative splice isoforms for METTL21A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for METTL21A Gene

Post-translational modifications for METTL21A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for METTL21A Gene

Domains & Families for METTL21A Gene

Gene Families for METTL21A Gene

Protein Domains for METTL21A Gene

Suggested Antigen Peptide Sequences for METTL21A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WXB1

UniProtKB/Swiss-Prot:

MT21A_HUMAN :
  • Belongs to the methyltransferase superfamily. METTL21 family.
Family:
  • Belongs to the methyltransferase superfamily. METTL21 family.
genes like me logo Genes that share domains with METTL21A: view

Function for METTL21A Gene

Molecular function for METTL21A Gene

UniProtKB/Swiss-Prot Function:
Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates Lys-561 in HSPA1, Lys-564 in HSPA2, Lys-585 in HSPA5, Lys-563 in HSPA6 and Lys-561 in HSPA8.

Enzyme Numbers (IUBMB) for METTL21A Gene

Gene Ontology (GO) - Molecular Function for METTL21A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
GO:0008168 methyltransferase activity IEA --
GO:0016279 protein-lysine N-methyltransferase activity TAS --
GO:0016740 transferase activity IEA --
GO:0030544 Hsp70 protein binding IPI 23921388
genes like me logo Genes that share ontologies with METTL21A: view

Phenotypes for METTL21A Gene

GenomeRNAi human phenotypes for METTL21A:
genes like me logo Genes that share phenotypes with METTL21A: view

Animal Model Products

CRISPR Products

miRNA for METTL21A Gene

miRTarBase miRNAs that target METTL21A

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL21A Gene

Localization for METTL21A Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL21A Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL21A gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for METTL21A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with METTL21A: view

Pathways & Interactions for METTL21A Gene

genes like me logo Genes that share pathways with METTL21A: view

Pathways by source for METTL21A Gene

Gene Ontology (GO) - Biological Process for METTL21A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006479 protein methylation TAS --
GO:0018022 peptidyl-lysine methylation IDA 23921388
GO:0032259 methylation IEA --
GO:0043462 NOT regulation of ATPase activity IDA 23921388
genes like me logo Genes that share ontologies with METTL21A: view

No data available for SIGNOR curated interactions for METTL21A Gene

Drugs & Compounds for METTL21A Gene

(2) Drugs for METTL21A Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Citalopram Approved Pharma 512
antidepressants Pharma 0
genes like me logo Genes that share compounds with METTL21A: view

Transcripts for METTL21A Gene

Unigene Clusters for METTL21A Gene

Methyltransferase like 21A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL21A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - - - - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: - -
SP6: -

Relevant External Links for METTL21A Gene

GeneLoc Exon Structure for
METTL21A
ECgene alternative splicing isoforms for
METTL21A

Expression for METTL21A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for METTL21A Gene

Protein differential expression in normal tissues from HIPED for METTL21A Gene

This gene is overexpressed in Spleen (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for METTL21A Gene



Protein tissue co-expression partners for METTL21A Gene

NURSA nuclear receptor signaling pathways regulating expression of METTL21A Gene:

METTL21A

SOURCE GeneReport for Unigene cluster for METTL21A Gene:

Hs.664764

Evidence on tissue expression from TISSUES for METTL21A Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with METTL21A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL21A Gene

Orthologs for METTL21A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for METTL21A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL21A 34 35
  • 99.08 (n)
dog
(Canis familiaris)
Mammalia METTL21A 34 35
  • 92.66 (n)
cow
(Bos Taurus)
Mammalia METTL21A 34 35
  • 91.13 (n)
mouse
(Mus musculus)
Mammalia Mettl21a 34 16 35
  • 88.84 (n)
rat
(Rattus norvegicus)
Mammalia LOC102553119 34
  • 88.23 (n)
oppossum
(Monodelphis domestica)
Mammalia METTL21A 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 29 (a)
ManyToMany
chicken
(Gallus gallus)
Aves METTL21A 34 35
  • 67.75 (n)
lizard
(Anolis carolinensis)
Reptilia METTL21A 35
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl21a 34
  • 62.31 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12020 34
zebrafish
(Danio rerio)
Actinopterygii mettl21a 34 35
  • 59.02 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1640 34
worm
(Caenorhabditis elegans)
Secernentea C42C1.13 35
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 26 (a)
OneToMany
EFM6 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
OneToMany
Species where no ortholog for METTL21A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL21A Gene

ENSEMBL:
Gene Tree for METTL21A (if available)
TreeFam:
Gene Tree for METTL21A (if available)

Paralogs for METTL21A Gene

Paralogs for METTL21A Gene

(3) SIMAP similar genes for METTL21A Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for METTL21A Gene

genes like me logo Genes that share paralogs with METTL21A: view

Variants for METTL21A Gene

Sequence variations from dbSNP and Humsavar for METTL21A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000146686 -- 207,598,956(+) TCAAG(C/G/T)TTGTT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1000180340 -- 207,621,257(+) ATGAC(A/T)AACTT intron-variant
rs1000195748 -- 207,620,975(+) CTGAC(A/G)TTTCT intron-variant
rs1000408351 -- 207,614,759(+) CACAT(A/T)AGGTC intron-variant
rs1000480716 -- 207,619,164(+) TCTAC(A/G)TAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for METTL21A Gene

Variant ID Type Subtype PubMed ID
dgv77n6 CNV deletion 16902084
esv2173449 CNV deletion 18987734
esv2523513 CNV deletion 19546169
esv2669520 CNV deletion 23128226
esv2671467 CNV deletion 23128226
esv2839347 CNV deletion 24192839
esv3560884 CNV deletion 23714750
esv3594090 CNV gain 21293372
esv3594091 CNV loss 21293372
esv996264 CNV deletion 20482838
nsv1013908 CNV loss 25217958
nsv1072486 CNV deletion 25765185
nsv1117323 CNV deletion 24896259
nsv1118891 CNV deletion 24896259
nsv3131 CNV deletion 18451855
nsv498953 CNV loss 21111241
nsv511834 CNV loss 21212237
nsv955000 CNV deletion 24416366

Variation tolerance for METTL21A Gene

Residual Variation Intolerance Score: 81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.29; 53.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for METTL21A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
METTL21A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL21A Gene

Disorders for METTL21A Gene

Relevant External Links for METTL21A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
METTL21A

No disorders were found for METTL21A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL21A Gene

Publications for METTL21A Gene

  1. Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation. (PMID: 23921388) Jakobsson M.E. … Falnes P.A.9. (J. Biol. Chem. 2013) 2 3 4 64
  2. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P. … Coulombe B. (PLoS Genet. 2013) 3 4 64
  3. Lysine methylation of VCP by a member of a novel human protein methyltransferase family. (PMID: 22948820) Kernstock S. … Falnes P.O. (Nat. Commun. 2012) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for METTL21A Gene

Sources for METTL21A Gene

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