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Aliases for METTL21A Gene

Aliases for METTL21A Gene

  • Methyltransferase Like 21A 2 3
  • Hepatocellular Carcinoma-Associated Antigen 557b 2 3 4
  • FAM119A 3 4 6
  • Heat Shock Protein 70kDa Lysine (K) Methyltransferase 2 3
  • Family With Sequence Similarity 119, Member A 2 3
  • Methyltransferase-Like Protein 21A 3 4
  • HSPA Lysine Methyltransferase 3 4
  • HSPA-KMT 3 4
  • HCA557b 3 4
  • Protein N-Lysine Methyltransferase METTL21A 3
  • Protein-Lysine Methyltransferase METTL21A 3
  • EC 2.1.1.- 4

External Ids for METTL21A Gene

Previous Symbols for METTL21A Gene

  • FAM119A

Summaries for METTL21A Gene

GeneCards Summary for METTL21A Gene

METTL21A (Methyltransferase Like 21A) is a Protein Coding gene. Diseases associated with METTL21A include hepatocellular carcinoma. GO annotations related to this gene include protein-lysine N-methyltransferase activity. An important paralog of this gene is VCPKMT.

UniProtKB/Swiss-Prot for METTL21A Gene

  • Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates Lys-561 in HSPA1, Lys-564 in HSPA2, Lys-585 in HSPA5, Lys-563 in HSPA6 and Lys-561 in HSPA8.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL21A Gene

Genomics for METTL21A Gene

Genomic Location for METTL21A Gene

207,580,631 bp from pter
207,625,928 bp from pter
45,298 bases
Minus strand

Genomic View for METTL21A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for METTL21A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL21A Gene

No data available for Regulatory Elements for METTL21A Gene

Proteins for METTL21A Gene

  • Protein details for METTL21A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein N-lysine methyltransferase METTL21A
    Protein Accession:
    Secondary Accessions:
    • Q53RV0
    • Q8N1Z9
    • Q96GH6

    Protein attributes for METTL21A Gene

    218 amino acids
    Molecular mass:
    24600 Da
    Quaternary structure:
    • Interacts with heat shock protein 70 family members; at least some of these proteins are methylation substrates (PubMed:23349634 and PubMed:23921388).

    Three dimensional structures from OCA and Proteopedia for METTL21A Gene

    Alternative splice isoforms for METTL21A Gene


neXtProt entry for METTL21A Gene

Proteomics data for METTL21A Gene at MOPED

Post-translational modifications for METTL21A Gene

No Post-translational modifications

No data available for DME Specific Peptides for METTL21A Gene

Domains for METTL21A Gene

Protein Domains for METTL21A Gene


  • Belongs to the methyltransferase superfamily. METTL21 family.:
    • Q8WXB1
genes like me logo Genes that share domains with METTL21A: view

No data available for Gene Families for METTL21A Gene

Function for METTL21A Gene

Molecular function for METTL21A Gene

UniProtKB/Swiss-Prot Function: Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates Lys-561 in HSPA1, Lys-564 in HSPA2, Lys-585 in HSPA5, Lys-563 in HSPA6 and Lys-561 in HSPA8.

Enzyme Numbers (IUBMB) for METTL21A Gene

Gene Ontology (GO) - Molecular Function for METTL21A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23921388
GO:0008168 methyltransferase activity --
GO:0008276 protein methyltransferase activity --
GO:0016279 protein-lysine N-methyltransferase activity IDA 22948820
GO:0030544 Hsp70 protein binding IPI 23921388
genes like me logo Genes that share ontologies with METTL21A: view

miRNA for METTL21A Gene

miRTarBase miRNAs that target METTL21A

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for METTL21A Gene

Localization for METTL21A Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL21A Gene


Gene Ontology (GO) - Cellular Components for METTL21A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with METTL21A: view

Pathways for METTL21A Gene

SuperPathways for METTL21A Gene

No Data Available

Gene Ontology (GO) - Biological Process for METTL21A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006479 protein methylation IDA 22948820
GO:0018022 peptidyl-lysine methylation IDA 23921388
GO:0043462 NOT regulation of ATPase activity IDA 23921388
genes like me logo Genes that share ontologies with METTL21A: view

No data available for Pathways by source for METTL21A Gene

Transcripts for METTL21A Gene

Unigene Clusters for METTL21A Gene

Methyltransferase like 21A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for METTL21A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - - - - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: - -
SP6: -

Relevant External Links for METTL21A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL21A Gene

mRNA expression in normal human tissues for METTL21A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for METTL21A Gene

SOURCE GeneReport for Unigene cluster for METTL21A Gene Hs.664764

genes like me logo Genes that share expressions with METTL21A: view

Orthologs for METTL21A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for METTL21A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia METTL21A 36
  • 99.08 (n)
  • 99.54 (a)
  • 100 (a)
(Bos Taurus)
Mammalia METTL21A 36
  • 91.13 (n)
  • 89.91 (a)
  • 90 (a)
(Canis familiaris)
Mammalia METTL21A 36
  • 92.66 (n)
  • 92.2 (a)
  • 83 (a)
(Mus musculus)
Mammalia Mettl21a 36
  • 88.84 (n)
  • 89.91 (a)
Mettl21a 16
Mettl21a 37
  • 90 (a)
(Monodelphis domestica)
Mammalia METTL21A 37
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 29 (a)
(Rattus norvegicus)
Mammalia LOC102553119 36
  • 88.23 (n)
  • 90.83 (a)
(Gallus gallus)
Aves METTL21A 36
  • 67.75 (n)
  • 68.52 (a)
  • 65 (a)
(Anolis carolinensis)
Reptilia METTL21A 37
  • 56 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12020 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl21a 36
  • 62.31 (n)
  • 58.41 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1640 36
(Danio rerio)
Actinopterygii mettl21a 36
  • 59.02 (n)
  • 60.09 (a)
mettl21a 37
  • 60 (a)
(Caenorhabditis elegans)
Secernentea C42C1.13 37
  • 23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 26 (a)
-- 39
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 33 (a)
Species with no ortholog for METTL21A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL21A Gene

Gene Tree for METTL21A (if available)
Gene Tree for METTL21A (if available)

Paralogs for METTL21A Gene

Paralogs for METTL21A Gene

Selected SIMAP similar genes for METTL21A Gene using alignment to 4 proteins: Pseudogenes for METTL21A Gene

genes like me logo Genes that share paralogs with METTL21A: view

Variants for METTL21A Gene

Sequence variations from dbSNP and Humsavar for METTL21A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1054941 -- 207,609,191(-) CCAGA(C/G)GTGAA utr-variant-3-prime
rs2252982 -- 207,612,456(-) TATAA(A/G)TAAAG utr-variant-3-prime
rs2361239 -- 207,618,656(-) ATCTC(A/G)GCTCA intron-variant
rs2464982 -- 207,612,121(-) actcc(A/G)tctca utr-variant-3-prime
rs2551941 -- 207,627,419(-) AAAAG(A/T)CCCTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for METTL21A Gene

Variant ID Type Subtype PubMed ID
nsv3131 CNV Loss 18451855
dgv77n6 CNV Loss 16902084
esv996264 CNV Deletion 20482838
esv2523513 CNV Deletion 19546169
esv2173449 CNV Deletion 18987734
nsv511834 CNV Loss 21212237
esv2669520 CNV Deletion 23128226
nsv498953 CNV Loss 21111241
esv2671467 CNV Deletion 23128226
nsv875742 CNV Gain 21882294

Relevant External Links for METTL21A Gene

HapMap Linkage Disequilibrium report

Disorders for METTL21A Gene

(1) MalaCards Diseases for METTL21A Gene

Search for METTL21A Gene in MalaCards »
genes like me logo Genes that share disorders with METTL21A: view

No data available for UniProtKB/Swiss-Prot for METTL21A Gene

Publications for METTL21A Gene

  1. Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation. (PMID: 23921388) Jakobsson M.E. … Falnes P.A.9. (J. Biol. Chem. 2013) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Lysine methylation of VCP by a member of a novel human protein methyltransferase family. (PMID: 22948820) Kernstock S. … Falnes P.O. (Nat. Commun. 2012) 3 4
  4. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P. … Coulombe B. (PLoS Genet. 2013) 3 4
  5. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3

Products for METTL21A Gene

Sources for METTL21A Gene

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