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Aliases for METTL21A Gene

Aliases for METTL21A Gene

  • Methyltransferase Like 21A 2 3
  • Hepatocellular Carcinoma-Associated Antigen 557b 2 3 4
  • Heat Shock Protein 70kDa Lysine (K) Methyltransferase 2 3
  • Family With Sequence Similarity 119, Member A 2 3
  • Methyltransferase-Like Protein 21A 3 4
  • HSPA Lysine Methyltransferase 3 4
  • HSPA-KMT 3 4
  • HCA557b 3 4
  • FAM119A 3 4
  • Protein-Lysine Methyltransferase METTL21A 3
  • EC 2.1.1.- 4

External Ids for METTL21A Gene

Previous HGNC Symbols for METTL21A Gene

  • FAM119A

Previous GeneCards Identifiers for METTL21A Gene

  • GC02M208446

Summaries for METTL21A Gene

GeneCards Summary for METTL21A Gene

METTL21A (Methyltransferase Like 21A) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity and Hsp70 protein binding. An important paralog of this gene is VCPKMT.

UniProtKB/Swiss-Prot for METTL21A Gene

  • Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates Lys-561 in HSPA1, Lys-564 in HSPA2, Lys-585 in HSPA5, Lys-563 in HSPA6 and Lys-561 in HSPA8.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL21A Gene

Genomics for METTL21A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for METTL21A Gene

Chromosome:
2
Start:
207,580,631 bp from pter
End:
207,625,928 bp from pter
Size:
45,298 bases
Orientation:
Minus strand

Genomic View for METTL21A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for METTL21A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL21A Gene

No data available for Regulatory Elements for METTL21A Gene

Proteins for METTL21A Gene

  • Protein details for METTL21A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXB1-MT21A_HUMAN
    Recommended name:
    Protein N-lysine methyltransferase METTL21A
    Protein Accession:
    Q8WXB1
    Secondary Accessions:
    • Q53RV0
    • Q8N1Z9
    • Q96GH6

    Protein attributes for METTL21A Gene

    Size:
    218 amino acids
    Molecular mass:
    24600 Da
    Quaternary structure:
    • Interacts with heat shock protein 70 family members; at least some of these proteins are methylation substrates (PubMed:23349634 and PubMed:23921388).

    Three dimensional structures from OCA and Proteopedia for METTL21A Gene

    Alternative splice isoforms for METTL21A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for METTL21A Gene

Proteomics data for METTL21A Gene at MOPED

Post-translational modifications for METTL21A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for METTL21A Gene

Domains & Families for METTL21A Gene

Gene Families for METTL21A Gene

Protein Domains for METTL21A Gene

Suggested Antigen Peptide Sequences for METTL21A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WXB1

UniProtKB/Swiss-Prot:

MT21A_HUMAN :
  • Belongs to the methyltransferase superfamily. METTL21 family.
Family:
  • Belongs to the methyltransferase superfamily. METTL21 family.
genes like me logo Genes that share domains with METTL21A: view

Function for METTL21A Gene

Molecular function for METTL21A Gene

UniProtKB/Swiss-Prot Function:
Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates Lys-561 in HSPA1, Lys-564 in HSPA2, Lys-585 in HSPA5, Lys-563 in HSPA6 and Lys-561 in HSPA8.

Enzyme Numbers (IUBMB) for METTL21A Gene

Gene Ontology (GO) - Molecular Function for METTL21A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23921388
GO:0016279 protein-lysine N-methyltransferase activity IDA 22948820
GO:0030544 Hsp70 protein binding IPI 23921388
GO:0051117 ATPase binding IPI 23921388
genes like me logo Genes that share ontologies with METTL21A: view

Animal Model Products

CRISPR Products

miRNA for METTL21A Gene

miRTarBase miRNAs that target METTL21A

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for METTL21A

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL21A Gene

Localization for METTL21A Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL21A Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for METTL21A Gene COMPARTMENTS Subcellular localization image for METTL21A gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for METTL21A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with METTL21A: view

Pathways & Interactions for METTL21A Gene

SuperPathways for METTL21A Gene

No Data Available

Gene Ontology (GO) - Biological Process for METTL21A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006479 protein methylation IDA 22948820
GO:0018022 peptidyl-lysine methylation IDA 23921388
GO:0043462 NOT regulation of ATPase activity IDA 23921388
genes like me logo Genes that share ontologies with METTL21A: view

No data available for Pathways by source and SIGNOR curated interactions for METTL21A Gene

Drugs & Compounds for METTL21A Gene

No Compound Related Data Available

Transcripts for METTL21A Gene

Unigene Clusters for METTL21A Gene

Methyltransferase like 21A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for METTL21A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL21A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - - - - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: - -
SP6: -

Relevant External Links for METTL21A Gene

GeneLoc Exon Structure for
METTL21A
ECgene alternative splicing isoforms for
METTL21A

Expression for METTL21A Gene

mRNA expression in normal human tissues for METTL21A Gene

Protein differential expression in normal tissues from HIPED for METTL21A Gene

This gene is overexpressed in Spleen (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for METTL21A Gene



SOURCE GeneReport for Unigene cluster for METTL21A Gene Hs.664764

genes like me logo Genes that share expression patterns with METTL21A: view

Protein tissue co-expression partners for METTL21A Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for METTL21A Gene

Orthologs for METTL21A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for METTL21A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia METTL21A 35
  • 91.13 (n)
  • 89.91 (a)
METTL21A 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia METTL21A 35
  • 92.66 (n)
  • 92.2 (a)
METTL21A 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mettl21a 35
  • 88.84 (n)
  • 89.91 (a)
Mettl21a 16
Mettl21a 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia METTL21A 35
  • 99.08 (n)
  • 99.54 (a)
METTL21A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102553119 35
  • 88.23 (n)
  • 90.83 (a)
oppossum
(Monodelphis domestica)
Mammalia METTL21A 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 29 (a)
ManyToMany
chicken
(Gallus gallus)
Aves METTL21A 35
  • 67.75 (n)
  • 68.52 (a)
METTL21A 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia METTL21A 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl21a 35
  • 62.31 (n)
  • 58.41 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12020 35
zebrafish
(Danio rerio)
Actinopterygii mettl21a 35
  • 59.02 (n)
  • 60.09 (a)
mettl21a 36
  • 60 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1640 35
worm
(Caenorhabditis elegans)
Secernentea C42C1.13 36
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 26 (a)
OneToMany
-- 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToMany
Species with no ortholog for METTL21A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL21A Gene

ENSEMBL:
Gene Tree for METTL21A (if available)
TreeFam:
Gene Tree for METTL21A (if available)

Paralogs for METTL21A Gene

Paralogs for METTL21A Gene

(3) SIMAP similar genes for METTL21A Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for METTL21A Gene

genes like me logo Genes that share paralogs with METTL21A: view

Variants for METTL21A Gene

Sequence variations from dbSNP and Humsavar for METTL21A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1054941 -- 207,609,191(-) CCAGA(C/G)GTGAA utr-variant-3-prime, intron-variant
rs2252982 -- 207,612,456(-) TATAA(A/G)TAAAG utr-variant-3-prime, intron-variant
rs2361239 -- 207,618,656(-) ATCTC(A/G)GCTCA intron-variant
rs2464982 -- 207,612,121(-) actcc(A/G)tctca utr-variant-3-prime, intron-variant
rs2551931 -- 207,606,756(+) GGGCC(A/G)CTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for METTL21A Gene

Variant ID Type Subtype PubMed ID
nsv3131 CNV Loss 18451855
dgv77n6 CNV Loss 16902084
esv996264 CNV Deletion 20482838
esv2523513 CNV Deletion 19546169
esv2173449 CNV Deletion 18987734
nsv511834 CNV Loss 21212237
esv2669520 CNV Deletion 23128226
nsv498953 CNV Loss 21111241
esv2671467 CNV Deletion 23128226
nsv875742 CNV Gain 21882294

Variation tolerance for METTL21A Gene

Residual Variation Intolerance Score: 81.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.29; 53.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for METTL21A Gene

HapMap Linkage Disequilibrium report
METTL21A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL21A Gene

Disorders for METTL21A Gene

Relevant External Links for METTL21A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
METTL21A
genes like me logo Genes that share disorders with METTL21A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL21A Gene

Publications for METTL21A Gene

  1. Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation. (PMID: 23921388) Jakobsson M.E. … Falnes P.A.9. (J. Biol. Chem. 2013) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. (PMID: 24529757) Xie T. … Xu R. (Neurobiol. Aging 2014) 67
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  5. Genome-wide association study identifies a potent locus associated with human opioid sensitivity. (PMID: 23183491) Nishizawa D. … Ikeda K. (Mol. Psychiatry 2014) 67

Products for METTL21A Gene

Sources for METTL21A Gene

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