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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

METTL21A Gene

protein-coding   GIFtS: 43
GCID: GC02M208446

methyltransferase like 21A

(Previous names: family with sequence similarity 119, member A )
(Previous symbol: FAM119A)
 Explore 2 diseases affiliated with
METTL21A via our new
 Human Malady Compendium 
Biological research products
for METTL21A
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Methyltransferase Like 21A1 2     Methyltransferase-Like Protein 21A2 3
FAM119A1 2 3     LOC1511941
HCA557b1 2     Protein-Lysine Methyltransferase METTL21A2
Family With Sequence Similarity 119, Member A1 2     EC 2.1.1.-3
Hepatocellular Carcinoma-Associated Antigen 557b2 3     HCA557B3

External Ids:    HGNC: 304761   Entrez Gene: 1511942   Ensembl: ENSG000001444017   UniProtKB: Q8WXB13   

Export aliases for METTL21A gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MT21A_HUMAN, Q8WXB1
Function: Protein-lysine methyltransferase




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for METTL21A
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMETTL21A promoter sequence
   Search SABiosciences Chromatin IP Primers for METTL21A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL21A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.3   Ensembl cytogenetic band:  2q33.3   HGNC cytogenetic band: 2q33.3

METTL21A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
METTL21A gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M208446:  view genomic region     (about GC identifiers)

Start:
208,445,355 bp from pter      End:
208,490,652 bp from pter
Size:
45,298 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MT21A_HUMAN, Q8WXB1 (See protein sequence)
Recommended Name: Protein-lysine methyltransferase METTL21A  
Size: 218 amino acids; 24600 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q53RV0 Q8N1Z9 Q96GH6
Alternative splicing: 2 isoforms:  Q8WXB1-1   Q8WXB1-2   

Explore the universe of human proteins at neXtProt for METTL21A: NX_Q8WXB1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8WXB1

  • METTL21A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001120867.1  NP_660323.3  

    ENSEMBL proteins: 
     ENSP00000416570   ENSP00000389684   ENSP00000400730   ENSP00000443458   ENSP00000407622  
     ENSP00000272839   ENSP00000409485   ENSP00000385481   ENSP00000403317   ENSP00000392062  
     ENSP00000415115  

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    Novus Biologicals METTL21A Protein
    Novus Biologicals METTL21A Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for METTL21A

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--


    METTL21A for ontologies           About GeneDecksing



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    Uscn Antibodies for METTL21A
    Search ThermoFisher Antibodies for METTL21A

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    Uscn ELISAs and CLIAs for METTL21A


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    METTL21A for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR019410 Nicotinamide_N-MeTfrase-like

    Graphical View of Domain Structure for InterPro Entry Q8WXB1

    ProtoNet protein and cluster: Q8WXB1

    UniProtKB/Swiss-Prot: MT21A_HUMAN, Q8WXB1
    Similarity: Belongs to the methyltransferase superfamily. METTL21 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: MT21A_HUMAN, Q8WXB1
    Function: Protein-lysine methyltransferase

    Enzyme Number (IUBMB): EC 2.1.1.-1

    miRNA
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    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate METTL21A (see all 14):
    hsa-miR-206 hsa-miR-769-5p hsa-miR-374b hsa-miR-146a hsa-let-7a-2* hsa-miR-374a hsa-miR-1 hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidMETTL21A 3' UTR sequence
    Inhib. RNA
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    Search LifeMap BioReagents cell lines for METTL21A

    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL21A

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008168methyltransferase activity ----
    GO:0016279protein-lysine N-methyltransferase activity IDA--


    METTL21A for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for METTL21A

    1 Interacting protein for METTL21A (Q8WXB13) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C5orf54Q8IZ133I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006479protein methylation IDA--
    GO:0018022peptidyl-lysine methylation IDA--


    METTL21A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    METTL21A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for METTL21A
    2 PharmGKB related drug/compound annotations for METTL21A gene
    Drug/compound PharmGKB Annotation
    antidepressantsCA  
    citalopramCA  
    About this table

    Search CenterWatch for drugs/clinical trials and news about METTL21A / MT21A 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for METTL21A gene (2 alternative transcripts): 
    NM_001127395.1  NM_145280.4  

    Unigene Cluster for METTL21A:

    Methyltransferase like 21A
    Hs.664764  [show with all ESTs]
    Unigene Representative Sequence: NM_001127395
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000432416 ENST00000458426(uc002vce.3) ENST00000425132 ENST00000461419
    ENST00000477919 ENST00000448007 ENST00000272839 ENST00000448823 ENST00000406927
    ENST00000426075 ENST00000442521 ENST00000471128 ENST00000411432(uc002vcf.2 uc010fuk.1 uc002vcg.3)


    miRNA
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    OriGene 3'-UTR Clone (see all 2): METTL21A
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat METTL21A
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate METTL21A (see all 14):
    hsa-miR-206 hsa-miR-769-5p hsa-miR-374b hsa-miR-146a hsa-let-7a-2* hsa-miR-374a hsa-miR-1 hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidMETTL21A 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for METTL21A
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL21A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL21A

    Additional cDNA sequence: 

    AF455817.1 AK093812.1 BC009462.1 BC033720.1 

    10 DOTS entries:

    DT.100019148  DT.70105278  DT.92421684  DT.92421681  DT.65288329  DT.100662962  DT.102843602  DT.92421683 
    DT.97840971  DT.97840973 

    24/70 AceView cDNA sequences (see all 70):

    BU166280 AV709173 BC009462 BQ959447 BQ068344 BQ961658 BM454660 BG334114 
    BQ086336 BQ230885 BP378318 CR601624 BM046315 BE326872 CK822993 AI565514 
    AX748320 AA701163 BG499308 BX100573 AF455817 BQ102412 AW270515 BM787650 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for METTL21A (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
    SP1:        -     -     -     -     -                 -                           
    SP2:                    -     -     -                 -                           
    SP3:                          -     -                 -                           
    SP4:                          -     -                                             
    SP5:                                -                 -                           


    ECgene alternative splicing isoforms for METTL21A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    METTL21A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTTACTTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See METTL21A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for METTL21A

    SOURCE GeneReport for Unigene cluster: Hs.664764
        SABiosciences Custom PCR Arrays for METTL21A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL21A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for METTL21A gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves METTL21A1 methyltransferase like 21A 67.91(n)
    68.84(a)
      424094  XM_421949.3  XP_421949.1 
    lizard
    (Anolis carolinensis)
    Reptilia METTL21A6
    --
    65(a)
    1 ↔ 1
    GL343343.1(101196-106154)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.120202 Xenopus laevis transcribed sequence with weak similarity more 76.57(n)    BJ625130.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mettl21a1 methyltransferase like 21A 59.02(n)
    60.09(a)
      541441  NM_001013566.1  NP_001013584.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G508506
    AT5G495606
    Putative methyltransferase family protein
    25(a)
    20(a)
    many ↔ many
    many ↔ many
    3(18901342-18902152)
    5(20110961-20111785)
    rice
    (Oryza sativa)
    Liliopsida --
    expressed protein
    19(a)
    1 → many
    7(22920000-22921485)


    ENSEMBL Gene Tree for METTL21A (if available)
    TreeFam Gene Tree for METTL21A (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for METTL21A gene
    METTL21D2  METTL21B2  METTL21C2  
    3 SIMAP similar genes for METTL21A using alignment to 5 protein entries:     MT21A_HUMAN (see all proteins):
    METTL22    METTL21B    METTL21D

    METTL21A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for METTL21A
    PGOHUM00000239085


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/268 NCBI SNPs in METTL21A are shown (see all 268    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1932340321,2
    --208473446(+) GAGATA/CGAGAC 2 -- ds50010--------
    rs25519511,2
    C,A,H,--208473468(-) TTTCAA/CCGTGT 2 -- ds50019Minor allele frequency- C:0.06NA WA CSA 16
    rs1848753711,2
    --208473537(+) TCCCAA/GCTACT 2 -- ds50010--------
    rs1889070711,2
    --208473544(+) TACTCA/GGGAGG 2 -- ds50010--------
    rs1489519911,2
    --208473567(+) AATGGC/TGTGAA 2 -- ds50010--------
    rs1437670241,2
    --208473612(+) TGCCCC/TGCACT 2 -- ds50010--------
    rs1815776111,2
    --208473613(+) GCCCCA/GCACTC 2 -- ds50010--------
    rs1510773041,2
    --208474037(+) AAGCTA/GTTGTT 2 -- ut310--------
    rs1148462951,2
    F,--208474038(+) AGCTAT/CTGTTT 2 -- ut311Minor allele frequency- C:0.02WA 118
    rs1852827421,2
    --208474122(+) AACAAC/TATAAC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for METTL21A (208445355 - 208490652 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for METTL21A: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing METTL21A
    DNA2.0 Custom Variant and Variant Library Synthesis for METTL21A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    METTL21A for disorders           About GeneDecksing

    2 diseases for METTL21A:    About MalaCards
    hepatocellular carcinoma    carcinoma


    Export disorders for METTL21A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for METTL21A gene integrated from 9 sources:
    (articles sorted by number of sources associating them with METTL21A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. Lysine methylation of VCP by a member of a novel human protein methyltransferase family. (PubMed id 22948820)2 Kernstock S.... Falnes P.O. (2012)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 151194 HGNC: 30476 AceView: LOC151194 Ensembl:ENSG00000144401 euGenes: HUgn151194
    ECgene: METTL21A H-InvDB: METTL21A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for METTL21A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for METTL21A gene:
    Search GeneIP for patents involving METTL21A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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