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METTL21A Gene

protein-coding   GIFtS: 46
GCID: GC02M208446

Methyltransferase Like 21A

(Previous names: family with sequence similarity 119, member A)
(Previous symbol: FAM119A)
  See METTL21A-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Methyltransferase Like 21A1 2     HSPA Lysine Methyltransferase2 3
FAM119A1 2 3 5     HCA557b2
Hepatocellular Carcinoma-Associated Antigen 557b1 2 3     Protein N-Lysine Methyltransferase METTL21A2
Family With Sequence Similarity 119, Member A1 2     Protein-Lysine Methyltransferase METTL21A2
Heat Shock Protein 70kDa Lysine (K) Methyltransferase1 2     EC 2.1.1.-3
Methyltransferase-Like Protein 21A2 3     HCA557B3
HSPA-KMT2 3     

External Ids:    HGNC: 304761   Entrez Gene: 1511942   Ensembl: ENSG000001444017   OMIM: 6152575   UniProtKB: Q8WXB13   

Export aliases for METTL21A gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for METTL21A Gene:
METTL21A (methyltransferase like 21A) is a protein-coding gene. Diseases associated with METTL21A include hepatocellular carcinoma. GO annotations related to this gene include protein-lysine N-methyltransferase activity. An important paralog of this gene is METTL21B.

UniProtKB/Swiss-Prot: MT21A_HUMAN, Q8WXB1
Function: Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70
(HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro
methylates 'Lys-561' in HSPA1, 'Lys-564' in HSPA2, 'Lys-585' in HSPA5, 'Lys-563' in HSPA6 and 'Lys-561' in HSPA8




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for METTL21A
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMETTL21A promoter sequence
   Search Chromatin IP Primers for METTL21A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat METTL21A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.3   Ensembl cytogenetic band:  2q33.3   HGNC cytogenetic band: 2q33.3

METTL21A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
METTL21A gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M208446:  view genomic region     (about GC identifiers)

Start:
208,445,355 bp from pter      End:
208,490,652 bp from pter
Size:
45,298 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 76,470,923-76,472,979     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MT21A_HUMAN, Q8WXB1 (See protein sequence)
Recommended Name: Protein N-lysine methyltransferase METTL21A  
Size: 218 amino acids; 24600 Da
Subunit: Interacts with heat shock protein 70 family members; at least some of these proteins are methylation
substrates (PubMed:23349634 and PubMed:23921388)
1 PDB 3D structure from and Proteopedia for METTL21A:
4LEC (3D)    
Secondary accessions: Q53RV0 Q8N1Z9 Q96GH6
Alternative splicing: 2 isoforms:  Q8WXB1-1   Q8WXB1-2   

Explore the universe of human proteins at neXtProt for METTL21A: NX_Q8WXB1

Explore proteomics data for METTL21A at MOPED


See METTL21A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001120867.1  NP_660323.3  

ENSEMBL proteins: 
 ENSP00000416570   ENSP00000389684   ENSP00000400730   ENSP00000407622   ENSP00000272839  
 ENSP00000409485   ENSP00000385481   ENSP00000403317   ENSP00000392062   ENSP00000415115  

METTL21A Human Recombinant Protein Products:

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Novus Biologicals METTL21A Proteins
Novus Biologicals METTL21A Lysates
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Cloud-Clone Corp. Proteins for METTL21A

 
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Search eBioscience for ELISAs for METTL21A 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR019410 Nicotinamide_N-MeTfrase-like

Graphical View of Domain Structure for InterPro Entry Q8WXB1

ProtoNet protein and cluster: Q8WXB1

UniProtKB/Swiss-Prot: MT21A_HUMAN, Q8WXB1
Similarity: Belongs to the methyltransferase superfamily. METTL21 family


Find genes that share domains with METTL21A           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: MT21A_HUMAN, Q8WXB1
Function: Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70
(HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro
methylates 'Lys-561' in HSPA1, 'Lys-564' in HSPA2, 'Lys-585' in HSPA5, 'Lys-563' in HSPA6 and 'Lys-561' in HSPA8

     Enzyme Number (IUBMB): EC 2.1.1.-1

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008168methyltransferase activity ----
GO:0008276protein methyltransferase activity ----
GO:0016279protein-lysine N-methyltransferase activity IDA--
     
Find genes that share ontologies with METTL21A           About GenesLikeMe


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for METTL21A
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   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for METTL21A

miRNA
Products:
    
miRTarBase miRNAs that target METTL21A:
hsa-mir-186-5p (MIRT045232)

Block miRNA regulation of human, mouse, rat METTL21A using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate METTL21A (see all 14):
hsa-miR-206 hsa-miR-769-5p hsa-miR-374b hsa-miR-146a hsa-let-7a-2* hsa-miR-374a hsa-miR-1 hsa-miR-342-3p
SwitchGear 3'UTR luciferase reporter plasmidMETTL21A 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for METTL21A
Predesigned siRNA for gene silencing in human, mouse, rat METTL21A

Gene Editing
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GenScript: all cDNA clones in your preferred vector (see all 2): METTL21A (NM_145280)
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for METTL21A
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL21A

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL21A


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
MT21A_HUMAN, Q8WXB1: Cytoplasm

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IEA--

Find genes that share ontologies with METTL21A           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for METTL21A
Interactions:

    Search GeneGlobe Interaction Network for METTL21A

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

5 Interacting proteins for METTL21A (Q8WXB13 ENSP000003854814) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
C5orf54Q8IZ133I2D: score=1 
MUS81ENSP000003078534STRING: ENSP00000307853
TMA16ENSP000003513804STRING: ENSP00000351380
FARS2ENSP000002746804STRING: ENSP00000274680
FDXACB1ENSP000002602574STRING: ENSP00000260257
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Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006479protein methylation IDA--
GO:0018022peptidyl-lysine methylation IDA--

Find genes that share ontologies with METTL21A           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for METTL21A (MT21A)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for METTL21A gene (2 alternative transcripts): 
NM_001127395.1  NM_145280.4  

Unigene Cluster for METTL21A:

Methyltransferase like 21A
Hs.664764  [show with all ESTs]
Unigene Representative Sequence: NM_001127395
13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000432416 ENST00000458426(uc002vce.3) ENST00000425132 ENST00000477919
ENST00000448007 ENST00000272839 ENST00000448823 ENST00000406927 ENST00000426075
ENST00000442521 ENST00000461419 ENST00000471128 ENST00000411432(uc002vcf.2 uc010fuk.1 uc002vcg.3)

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat METTL21A using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate METTL21A (see all 14):
hsa-miR-206 hsa-miR-769-5p hsa-miR-374b hsa-miR-146a hsa-let-7a-2* hsa-miR-374a hsa-miR-1 hsa-miR-342-3p
SwitchGear 3'UTR luciferase reporter plasmidMETTL21A 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for METTL21A
Predesigned siRNA for gene silencing in human, mouse, rat METTL21A
Clone
Products:
     
OriGene clones in human, mouse for METTL21A (see all 11)
OriGene ORF clones in mouse, rat for METTL21A
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GenScript: all cDNA clones in your preferred vector (see all 2): METTL21A (NM_145280)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for METTL21A
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL21A
Primer
Products:
    
OriGene qPCR primer pairs and template standards for METTL21A
OriGene qSTAR qPCR primer pairs in human, mouse for METTL21A
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat METTL21A
  QuantiTect SYBR Green Assays in human, mouse, rat METTL21A
  QuantiFast Probe-based Assays in human, mouse, rat METTL21A

Additional mRNA sequence: 

AF455817.1 AK093812.1 BC009462.1 BC033720.1 

10 DOTS entries:

DT.100019148  DT.70105278  DT.92421684  DT.92421681  DT.65288329  DT.100662962  DT.102843602  DT.92421683 
DT.97840971  DT.97840973 

Selected AceView cDNA sequences (see all 70):

BQ959447 BG334114 BQ086336 AV709173 BP378318 CR601624 BQ230885 BQ068344 
BC009462 BU166280 BQ961658 BM454660 BF431019 AW270515 BQ102412 BU072193 
AW074417 BX100573 CK822992 BG614244 AI332764 BE326872 BG476378 BC033720 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for METTL21A (see all 6)    About this scheme

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
SP1:        -     -     -     -     -                 -                           
SP2:                    -     -     -                 -                           
SP3:                          -     -                 -                           
SP4:                          -     -                                             
SP5:                                -                 -                           


ECgene alternative splicing isoforms for METTL21A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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METTL21A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTTTACTTGT
METTL21A Expression
About this image

METTL21A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

METTL21A Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.664764
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QuantiFast Probe-based Assays in human, mouse, rat METTL21A
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL21A

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for METTL21A gene from Selected species (see all 16)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Mettl21a1 , 5 methyltransferase like 21A1, 5 88.84(n)1
89.91(a)1
  1 (32.74 cM)5
670991  NM_025964.31  NP_080240.11 
 646064735 
chicken
(Gallus gallus)
Aves METTL21A1 methyltransferase like 21A 67.75(n)
68.52(a)
  424094  NM_001277844.1  NP_001264773.1 
lizard
(Anolis carolinensis)
Reptilia METTL21A6
methyltransferase like 21A
56(a)
1 ↔ 1
GL343343.1(101196-108465)
African clawed frog
(Xenopus laevis)
Amphibia Xl.120202 Xenopus laevis transcribed sequence with weak similarity more 76.57(n)    BJ625130.1 
zebrafish
(Danio rerio)
Actinopterygii mettl21a1 methyltransferase like 21A 59.02(n)
60.09(a)
  541441  NM_001013566.2  NP_001013584.1 
worm
(Caenorhabditis elegans)
Secernentea C42C1.136
Protein C42C1.13, isoform b
23(a)
1 → many
IV(12278767-12279546) WBGene00016591
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes (YNL024C)4 Putative protein of unknown function with seven beta-strand more   --   14(587847-587107) 855707  NP_014374.1 


ENSEMBL Gene Tree for METTL21A (if available)
TreeFam Gene Tree for METTL21A (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for METTL21A gene
METTL21B2  METTL21C2  VCPKMT2  
3 SIMAP similar genes for METTL21A using alignment to 4 protein entries:     MT21A_HUMAN (see all proteins):
METTL21B    METTL21EP    VCPKMT

Find genes that share paralogs with METTL21A           About GenesLikeMe


1 Pseudogenes.org Pseudogene for METTL21A
PGOHUM00000239085


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for METTL21A (see all 346)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1932340321,2
--208473446(+) GAGATA/CGAGAC 2 -- ds50010--------
rs25519511,2
C,A,H--208473468(-) TTTCAA/CCGTGT 2 -- ds50019Minor allele frequency- C:0.06NA WA CSA 16
rs1848753711,2
--208473537(+) TCCCAA/GCTACT 2 -- ds50010--------
rs1889070711,2
--208473544(+) TACTCA/GGGAGG 2 -- ds50010--------
rs1489519911,2
C--208473567(+) AATGGC/TGTGAA 2 -- ds50010--------
rs1437670241,2
--208473612(+) TGCCCC/TGCACT 2 -- ds50010--------
rs1815776111,2
--208473613(+) GCCCCA/GCACTC 2 -- ds50010--------
rs1510773041,2
--208474037(+) AAGCTA/GTTGTT 2 -- ut310--------
rs1148462951,2
C,F--208474038(+) AGCTAT/CTGTTT 2 -- ut311Minor allele frequency- C:0.02WA 118
rs1852827421,2
--208474122(+) AACAAC/TATAAC 2 -- ut310--------

HapMap Linkage Disequilibrium report for METTL21A (208445355 - 208490652 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10 variations for METTL21A:    About this table    
Variant IDTypeSubtypePubMed ID
esv2669520CNV Deletion23128226
esv2671467CNV Deletion23128226
esv2523513CNV Deletion19546169
esv2173449CNV Deletion18987734
esv996264CNV Deletion20482838
nsv3131CNV Loss18451855
dgv77n6CNV Loss16902084
nsv511834CNV Loss21212237
nsv498953CNV Loss21111241
nsv875742CNV Gain21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing METTL21A
DNA2.0 Custom Variant and Variant Library Synthesis for METTL21A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 615257    OMIM disorders: --

1 disease for METTL21A:    
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hepatocellular carcinoma


Find genes that share disorders with METTL21A           About GenesLikeMe


Export disorders for METTL21A gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for METTL21A gene integrated from 10 sources:
(articles sorted by number of sources associating them with METTL21A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation. (PubMed id 23921388)1, 2, 3 Jakobsson M.E....Falnes P.A.9. (J. Biol. Chem. 2013)
  2. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1, 2 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. Genome-wide association study identifies a potent locus associated with human opioid sensitivity. (PubMed id 23183491)1 Nishizawa D....Ikeda K. (Mol. Psychiatry 2014)
  5. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
  6. Lysine methylation of VCP by a member of a novel human protein methyltransferase family. (PubMed id 22948820)2 Kernstock S.... Falnes P.O. (Nat. Commun. 2012)
  7. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
  8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  10. (PubMed id )2 

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 151194 HGNC: 30476 AceView: LOC151194 Ensembl:ENSG00000144401 euGenes: HUgn151194
ECgene: METTL21A H-InvDB: METTL21A

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for METTL21A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for METTL21A gene:
Search GeneIP for patents involving METTL21A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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