METTL20 Gene
protein-coding GIFtS: 37
GCID: GC12P031800
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methyltransferase like 20(Previous name: chromosome 12 open reading frame 72 )
(Previous symbol: C12orf72)
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Aliases
for METTL20 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Methyltransferase Like 201 2 | | Chromosome 12 Open Reading Frame 721 | | C12orf721 2 3 | | Methyltransferase-Like Protein 202 | | DKFZp451L2351 | | EC 2.1.1.-3 | | MGC505591 | | |
Export aliases for METTL20 gene to outside databases |
Summaries
for METTL20 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MET20_HUMAN, Q8IXQ9Function: Probable methyltransferase (By similarity)
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Genomic Views
for METTL20 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009714.17
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for METTL20
Other transcription factors
Search SABiosciences Chromatin IP Primers for METTL20
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL20 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p11.21 Ensembl cytogenetic band: 12p11.21 HGNC cytogenetic band: 12p11.21METTL20 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P031800: view genomic region
(about GC identifiers)
Start:
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31,800,094 bp from pter |
End:
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31,826,048 bp from pter |
Size:
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25,955 bases |
Orientation:
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plus strand |
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Proteins
for METTL20 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MET20_HUMAN, Q8IXQ9 (See
protein sequence)Recommended Name: Methyltransferase-like protein 20 Size: 262 amino acids; 29461 Da
Secondary accessions: D3DUW3Explore the universe of human proteins at neXtProt for METTL20: NX_Q8IXQ9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IXQ9
METTL20 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001129335.1 NP_001129336.1 NP_776163.1
ENSEMBL proteins: ENSP00000396123 ENSP00000379112 ENSP00000441421 ENSP00000350353 ENSP00000445165 ENSP00000437442
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005737 | cytoplasm |
IEA | -- |
METTL20 for ontologies About GeneDecksing
METTL20 Antibody Products:
Assay Products for METTL20: |
Protein
Domains /
Families
for METTL20 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
METTL20 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8IXQ9ProtoNet protein and cluster: Q8IXQ9 UniProtKB/Swiss-Prot: MET20_HUMAN, Q8IXQ9Similarity: Belongs to the methyltransferase superfamily. METTL20 family |
Function
for METTL20 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MET20_HUMAN, Q8IXQ9Function: Probable methyltransferase (By similarity)Enzyme Number (IUBMB): EC 2.1.1.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL20 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL20 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): METTL20 (NM_173802) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for METTL20 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL20 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL20 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008276 | protein methyltransferase activity |
IEA | -- |
METTL20 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for METTL20:
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Pathways & Interactions
for METTL20 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for METTL20
|
Drugs & Compounds
for METTL20 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for METTL20
Search CenterWatch for drugs/clinical trials and news about METTL20 / MET20
|
Transcripts
for METTL20 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for METTL20 gene (3 alternative transcripts): NM_001135863.1 NM_001135864.1 NM_173802.3 Unigene Cluster for METTL20: Methyltransferase like 20 Hs.740628 [show with all ESTs]Unigene Representative Sequence: AL8323396 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000412352 ENST00000395763(uc001rkl.3) ENST00000538463 ENST00000357721(uc009zjr.3 uc001rkm.3)
ENST00000539633 ENST00000538391
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL20 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL20 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): METTL20 (NM_173802) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for METTL20 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL20 |
Additional cDNA sequence: AK094708.1 AK290248.1 AL832339.1 BC039107.1 BC039417.1 BC039535.1 12 DOTS entries: DT.40261427 DT.307269 DT.95360465 DT.101980772 DT.95214858 DT.95172234 DT.95227408 DT.100750006 DT.121186775 DT.121186785 DT.99981006 DT.100836897 24/35 AceView cDNA sequences (see all 35): BC039535 BM129614 NM_173802 CR607465 CD365452 AA911463 BM129806 BM129337 CK819600 AW272460 BX444540 BC039107 F20667 BM460012 BX440980 AI302347 BC039417 BX098492 AA810345 BM559730 BQ012226 AI910578 AL832339 AI149303
GeneLoc Exon Structure
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Expression
for METTL20 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| METTL20 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See METTL20 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for METTL20
SOURCE GeneReport for Unigene cluster: Hs.740628
SABiosciences Custom PCR Arrays for METTL20
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for METTL20
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat METTL20 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL20 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL20 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL20 |
Orthologs
for METTL20 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for METTL20 gene from 6/15 species (see all 15) About this table
ENSEMBL Gene Tree for METTL20 (if available)
TreeFam Gene Tree for METTL20 (if available) |
Paralogs
for METTL20 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for METTL20 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for METTL20 (31800094 - 31826048 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for METTL20: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing METTL20 |
|
Disorders
/ Diseases
for METTL20 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for METTL20 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for METTL20 gene integrated from 9 sources:
(articles sorted by number of sources associating them with METTL20) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for METTL20 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing METTL20 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing METTL20 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing METTL20 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for METTL20 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for METTL20 gene:
Search GeneIP for patents involving METTL20
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for METTL20 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for METTL20 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for METTL20 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for METTL20 | | | OriGene Protein Over-expression Lysate for METTL20 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for METTL20 | | OriGene 3'-UTR Clone for METTL20 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL20 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL20 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for METTL20 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for METTL20 | | OriGene Custom Protein Services for METTL20 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat METTL20 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing METTL20 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL20 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat METTL20 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL20 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL20 |
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 |  |  |  | |
| | | | Search Tocris compounds for METTL20 |
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 | | | METTL20 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL20 |
|  |  |  | | | | Search ThermoFisher Antibodies for METTL20 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL20 |
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