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Aliases for METTL20 Gene

Aliases for METTL20 Gene

  • Methyltransferase Like 20 2 3
  • C12orf72 3 4 6
  • Protein N-Lysine Methyltransferase METTL20 3
  • Chromosome 12 Open Reading Frame 72 2
  • Methyltransferase-Like Protein 20 3
  • EC 2.1.1.- 4

External Ids for METTL20 Gene

Previous HGNC Symbols for METTL20 Gene

  • C12orf72

Previous GeneCards Identifiers for METTL20 Gene

  • GC12P031800

Summaries for METTL20 Gene

GeneCards Summary for METTL20 Gene

METTL20 (Methyltransferase Like 20) is a Protein Coding gene. GO annotations related to this gene include protein methyltransferase activity.

UniProtKB/Swiss-Prot for METTL20 Gene

  • Protein-lysine methyltransferase that selectively trimethylates residues in the electron transfer flavoprotein ETFB in mitochondria.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL20 Gene

Genomics for METTL20 Gene

Genomic Location for METTL20 Gene

31,647,160 bp from pter
31,673,114 bp from pter
25,955 bases
Plus strand

Genomic View for METTL20 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for METTL20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL20 Gene

No data available for Regulatory Elements for METTL20 Gene

Proteins for METTL20 Gene

  • Protein details for METTL20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein N-lysine methyltransferase METTL20
    Protein Accession:
    Secondary Accessions:
    • D3DUW3

    Protein attributes for METTL20 Gene

    262 amino acids
    Molecular mass:
    29461 Da
    Quaternary structure:
    • Interacts with HSPD1; this protein may possibly be a methylation substrate.

neXtProt entry for METTL20 Gene

Proteomics data for METTL20 Gene at MOPED

Post-translational modifications for METTL20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for METTL20 Gene

No data available for DME Specific Peptides for METTL20 Gene

Domains for METTL20 Gene

Protein Domains for METTL20 Gene


Suggested Antigen Peptide Sequences for METTL20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8IXQ9
  • Belongs to the methyltransferase superfamily. METTL20 family.
genes like me logo Genes that share domains with METTL20: view

No data available for Gene Families for METTL20 Gene

Function for METTL20 Gene

Molecular function for METTL20 Gene

UniProtKB/Swiss-Prot Function: Protein-lysine methyltransferase that selectively trimethylates residues in the electron transfer flavoprotein ETFB in mitochondria.

Enzyme Numbers (IUBMB) for METTL20 Gene

Gene Ontology (GO) - Molecular Function for METTL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0008276 protein methyltransferase activity --
genes like me logo Genes that share ontologies with METTL20: view

Phenotypes for METTL20 Gene

GenomeRNAi human phenotypes for METTL20:
genes like me logo Genes that share phenotypes with METTL20: view

Animal Model Products

CRISPR Products

miRNA for METTL20 Gene

miRTarBase miRNAs that target METTL20

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for METTL20 Gene

Localization for METTL20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL20 Gene

Cytoplasm. Mitochondrion matrix. Note=Concentrated in cytoplasmic granular foci. {ECO:0000269 PubMed:23349634}.

Gene Ontology (GO) - Cellular Components for METTL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005759 mitochondrial matrix IEA --
genes like me logo Genes that share ontologies with METTL20: view

No data available for Subcellular locations from COMPARTMENTS for METTL20 Gene

Pathways for METTL20 Gene

SuperPathways for METTL20 Gene

No Data Available

Interacting Proteins for METTL20 Gene

Gene Ontology (GO) - Biological Process for METTL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006479 protein methylation --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL20: view

No data available for Pathways by source for METTL20 Gene

Transcripts for METTL20 Gene

Unigene Clusters for METTL20 Gene

Methyltransferase like 20:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for METTL20

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for METTL20

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL20 Gene

No ASD Table

Relevant External Links for METTL20 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL20 Gene

mRNA expression in normal human tissues for METTL20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for METTL20 Gene

SOURCE GeneReport for Unigene cluster for METTL20 Gene Hs.740628

genes like me logo Genes that share expressions with METTL20: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for METTL20 Gene

Orthologs for METTL20 Gene

This gene was present in the common ancestor of animals.

Orthologs for METTL20 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia METTL20 35
  • 99.62 (n)
  • 99.24 (a)
METTL20 36
  • 99 (a)
(Bos Taurus)
Mammalia METTL20 35
  • 89.31 (n)
  • 83.59 (a)
METTL20 36
  • 82 (a)
(Canis familiaris)
Mammalia METTL20 35
  • 88.93 (n)
  • 86.64 (a)
METTL20 36
  • 85 (a)
(Mus musculus)
Mammalia Mettl20 35
  • 82.22 (n)
  • 78.82 (a)
Mettl20 16
Mettl20 36
  • 80 (a)
(Monodelphis domestica)
Mammalia METTL20 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia METTL20 36
  • 56 (a)
(Rattus norvegicus)
Mammalia Mettl20 35
  • 84.18 (n)
  • 80.78 (a)
(Gallus gallus)
Aves METTL20 35
  • 72.37 (n)
  • 73.68 (a)
METTL20 36
  • 66 (a)
(Anolis carolinensis)
Reptilia METTL20 36
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486545 35
  • 61.68 (n)
  • 61.21 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4768 35
(Danio rerio)
Actinopterygii mettl20 35
  • 61.27 (n)
  • 59.72 (a)
mettl20 36
  • 53 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007652 35
  • 48.67 (n)
  • 39.91 (a)
(Caenorhabditis elegans)
Secernentea C37A2.6 35
  • 52.07 (n)
  • 44.28 (a)
C37A2.6 36
  • 36 (a)
Species with no ortholog for METTL20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL20 Gene

Gene Tree for METTL20 (if available)
Gene Tree for METTL20 (if available)

Paralogs for METTL20 Gene

No data available for Paralogs for METTL20 Gene

Variants for METTL20 Gene

Sequence variations from dbSNP and Humsavar for METTL20 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs719692 -- 31,662,161(+) AGTTG(A/C/T)GGCTT synonymous-codon, reference, missense
rs900609 -- 31,663,833(-) AAGTG(C/T)GGTTT intron-variant
rs900610 -- 31,663,689(-) CTGAT(C/T)CGTTG intron-variant
rs2086777 -- 31,668,434(-) TTCCA(G/T)CCTGG utr-variant-3-prime
rs2170768 -- 31,668,327(-) TCCTC(A/G)ACTAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for METTL20 Gene

Variant ID Type Subtype PubMed ID
nsv832365 CNV Loss 17160897
nsv662 CNV Insertion 18451855
esv2495218 CNV Insertion 19546169
esv1351884 CNV Insertion 17803354
nsv898966 CNV Gain 21882294
nsv522379 CNV Loss 19592680

Relevant External Links for METTL20 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL20 Gene

Disorders for METTL20 Gene

No disorders were found for METTL20 Gene.

No data available for UniProtKB/Swiss-Prot for METTL20 Gene

Publications for METTL20 Gene

  1. Human METTL20 methylates lysine residues adjacent to the recognition loop of the electron transfer flavoprotein in mitochondria. (PMID: 25023281) Rhein V.F. … Walker J.E. (J. Biol. Chem. 2014) 2 3 4
  2. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P. … Coulombe B. (PLoS Genet. 2013) 3 4
  3. Human METTL20 is a mitochondrial lysine methyltransferase that targets the I^ subunit of electron transfer flavoprotein (ETFI^) and modulates its activity. (PMID: 25416781) MaA8ecki J. … Falnes P.A.9. (J. Biol. Chem. 2015) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for METTL20 Gene

Sources for METTL20 Gene

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