Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



METTL18 Gene

protein-coding   GIFtS: 44
GCID: GC01M169762

Methyltransferase Like 18

(Previous name: chromosome 1 open reading frame 156)
(Previous symbol: C1orf156)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Methyltransferase Like 181 2     Histidine Protein Methyltransferase 11
C1orf1561 2 3 5     HPM12
Arsenic-Transactivated Protein 22 3     Histidine Protein Methyltransferase 1 Homolog2
Methyltransferase-Like Protein 182 3     ASTP23
AsTP22 3     EC 2.1.1.-3
Chromosome 1 Open Reading Frame 1561     

External Ids:    HGNC: 287931   Entrez Gene: 923422   Ensembl: ENSG000001718067   OMIM: 6152555   UniProtKB: O955683   

Export aliases for METTL18 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for METTL18 Gene:
METTL18 (methyltransferase like 18) is a protein-coding gene. Diseases associated with METTL18 include essential hypertension, and hypertension. GO annotations related to this gene include protein methyltransferase activity.

UniProtKB/Swiss-Prot: MET18_HUMAN, O95568
Function: Probable histidine methyltransferase (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for METTL18
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for METTL18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat METTL18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24.2   Ensembl cytogenetic band:  1q24.2   HGNC cytogenetic band: 1q24.2

METTL18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
METTL18 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M169762:  view genomic region     (about GC identifiers)

Start:
169,761,670 bp from pter      End:
169,764,107 bp from pter
Size:
2,438 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MET18_HUMAN, O95568 (See protein sequence)
Recommended Name: Histidine protein methyltransferase 1 homolog  
Size: 372 amino acids; 42148 Da
Subunit: Interacts with GRWD1, RPL3 and members of the heat shock protein 90 and 70 families; these proteins may
possibly be methylation substrates for the enzyme (PubMed:23349634)
Secondary accessions: B2R9T5

Explore the universe of human proteins at neXtProt for METTL18: NX_O95568

Explore proteomics data for METTL18 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See METTL18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_219486.1  
    ENSEMBL proteins: 
     ENSP00000307077   ENSP00000307975   ENSP00000402305  

    METTL18 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for METTL18
    OriGene Protein Over-expression Lysate for METTL18
    OriGene MassSpec for METTL18
    OriGene Custom Protein Services for METTL18
    GenScript Custom Purified and Recombinant Proteins Services for METTL18
    Novus Biologicals METTL18 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for METTL18

    METTL18 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for METTL18
    Novus Biologicals METTL18 Antibody
    Abcam antibodies for METTL18
    Cloud-Clone Corp. Antibodies for METTL18
    Search ThermoFisher Antibodies for METTL18
    Search LSBio for Antibodies for METTL18

    METTL18 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for METTL18
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for METTL18
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for METTL18
    Cloud-Clone Corp. CLIAs for METTL18


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR019410 Nicotinamide_N-MeTfrase-like
     IPR010456 Ribosomal-L11_MeTrfase_PrmA

    Graphical View of Domain Structure for InterPro Entry O95568

    ProtoNet protein and cluster: O95568

    UniProtKB/Swiss-Prot: MET18_HUMAN, O95568
    Similarity: Belongs to the methyltransferase superfamily. METTL18 family


    METTL18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MET18_HUMAN, O95568
    Function: Probable histidine methyltransferase (By similarity)

         Enzyme Number (IUBMB): EC 2.1.1.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008168methyltransferase activity ----
    GO:0008276protein methyltransferase activity IEA--
         
    METTL18 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for METTL18:
     Decreased viability with pacli  Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for METTL18
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for METTL18

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for METTL18
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for METTL18

    miRNA
    Products:
        
    miRTarBase miRNAs that target METTL18:
    hsa-mir-532-3p (MIRT037916)

    Block miRNA regulation of human, mouse, rat METTL18 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate METTL18
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for METTL18
    Predesigned siRNA for gene silencing in human, mouse, rat METTL18

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for METTL18

    Clone
    Products:
         
    OriGene clones in human, mouse for METTL18 (see all 6)
    OriGene ORF clones in mouse, rat for METTL18
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: METTL18 (NM_033418)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for METTL18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL18

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for METTL18
    Browse ESI BIO Cell Lines and PureStem Progenitors for METTL18 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL18


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    METTL18 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for METTL18
    Interactions:

        Search GeneGlobe Interaction Network for METTL18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for METTL18 (O955682, 3 ENSP000003070774) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    B3GALT4O960242, 3MINT-8249190 I2D: score=2 
    ENSG00000226936O960242, 3MINT-8249190 I2D: score=2 
    ENSG00000235155O960242, 3MINT-8249190 I2D: score=2 
    YAE1D1Q9NRH12, 3, ENSP000002232734MINT-8250135 I2D: score=2 STRING: ENSP00000223273
    RGS2P412202, 3MINT-8268680 I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006479protein methylation ----

    METTL18 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for METTL18 (MET18)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for METTL18 gene: 
    NM_033418.2  

    Unigene Cluster for METTL18:

    Methyltransferase like 18
    Hs.33922  [show with all ESTs]
    Unigene Representative Sequence: NM_033418
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000303469 ENST00000310392(uc001ggn.3) ENST00000454472
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat METTL18 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate METTL18
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for METTL18
    Predesigned siRNA for gene silencing in human, mouse, rat METTL18
    Clone
    Products:
         
    OriGene clones in human, mouse for METTL18 (see all 6)
    OriGene ORF clones in mouse, rat for METTL18
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: METTL18 (NM_033418)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for METTL18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL18
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for METTL18
    OriGene qSTAR qPCR primer pairs in human, mouse for METTL18
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat METTL18
      QuantiTect SYBR Green Assays in human, mouse, rat METTL18
      QuantiFast Probe-based Assays in human, mouse, rat METTL18

    Additional mRNA sequence: 

    AK313909.1 AL035369.1 AY744366.1 BC008679.1 CR450330.1 

    4 DOTS entries:

    DT.314364  DT.100744152  DT.91757156  DT.121415911 

    Selected AceView cDNA sequences (see all 72):

    CB112786 AL035369 BC008679 AI492439 CR602834 NM_033418 CR609500 CR600232 
    CR450330 BQ016169 BM702845 AA830352 BU631100 BF111615 AA905464 AL556604 
    AI337857 N71424 AA247978 AW615333 AI347654 AW466982 BG614785 AI051822 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    METTL18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAAGTTATC
    METTL18 Expression
    About this image

    METTL18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    METTL18 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.33922
        Custom PCR Arrays for METTL18
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for METTL18
    OriGene qSTAR qPCR primer pairs in human, mouse for METTL18
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat METTL18
    QuantiTect SYBR Green Assays in human, mouse, rat METTL18
    QuantiFast Probe-based Assays in human, mouse, rat METTL18
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for METTL18 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mettl181 , 5 RIKEN cDNA 2810422O20 gene5
    methyltransferase like 181
    77.69(n)1
    71.67(a)1
      1 (71.30 cM)5
    699621  NM_027279.21  NP_081555.21 
     1639948895 
    chicken
    (Gallus gallus)
    Aves METTL181 methyltransferase like 18 65.69(n)
    61.76(a)
      424400  XM_422244.4  XP_422244.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.158022 Xenopus laevis transcribed sequence with weak similarity more 73.75(n)    BJ078128.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7967501 C1orf156-like 56.01(n)
    51.67(a)
      796750  NM_001145617.1  NP_001139089.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG172191 CG17219 51.69(n)
    48.79(a)
      33515  NM_134896.5  NP_608740.2 
    worm
    (Caenorhabditis elegans)
    Secernentea K01A11.21 K01A11.2 52.49(n)
    44.75(a)
      186828  NM_065306.1  NP_497707.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HPM1(YIL110W)4 AdoMet-dependent methyltransferase involved in a novel more   --   9(156045-157178) 854696  NP_012156.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G140001 AT4G14000 47.25(n)
    39.91(a)
      827036  NM_117475.3  NP_567417.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g03599001 Os09g0359900 49.34(n)
    40.1(a)
      4346844  NM_001069511.1  NP_001062976.1 


    ENSEMBL Gene Tree for METTL18 (if available)
    TreeFam Gene Tree for METTL18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for METTL18 (see all 48)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1447458861,2
    C--169761205(+) TCCCTC/TTGTTT 1 -- int10--------
    rs1512398881,2
    --169761279(+) GAATAC/TAAAAA 1 -- int10--------
    rs168626851,2
    F--169761316(+) TTTACA/GTAAGG 1 -- int13Minor allele frequency- G:0.01NA 142
    rs121455741,2
    C,F,H--169761370(+) ACTAAC/TGAAGA 1 -- int112Minor allele frequency- T:0.04NS EA NA WA 922
    rs1807030921,2
    --169761533(+) TGCACA/GAGGAT 1 -- int10--------
    rs1841983521,2
    --169761579(+) TAACAC/TAGCTC 1 -- int10--------
    rs121353611,2
    C,F,A,H--169761591(+) CTTACA/GATTTG 1 -- int119Minor allele frequency- G:0.04NS EA NA 2358
    rs121166501,2
    C,F--169761617(+) ACAAAC/AAACAT 1 -- int12Minor allele frequency- A:0.07NA EA 240
    rs121361261,2
    C,F,H--169761689(+) GTTTAT/CTTCAT 1 -- ut315Minor allele frequency- C:0.01NS EA EU 1357
    rs133757011,2,,4
    C,F,H--169761758(+) ACCTCT/ATCAAT 2 /K /M mis1 ese314Minor allele frequency- A:0.02NS EA NA WA EU 6393

    HapMap Linkage Disequilibrium report for METTL18 (169761670 - 169764107 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for METTL18: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing METTL18
    DNA2.0 Custom Variant and Variant Library Synthesis for METTL18

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 615255    OMIM disorders: --

    5 diseases for METTL18:    About MalaCards
    essential hypertension    hypertension    t-cell leukemia    malaria
    leukemia


    METTL18 for disorders           About GeneDecksing


    Export disorders for METTL18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for METTL18 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with METTL18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1, 2 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    2. A novel 3-methylhistidine modification of yeast ribosomal protein Rpl3 is dependent upon the YIL110W methyltransferase. (PubMed id 20864530)1, 3 Webb K.J....Clarke S.G. (J. Biol. Chem. 2010)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    6. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1 Ehret G.B....Chakravarti A. (Eur. J. Hum. Genet. 2009)
    7. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PubMed id 19064610)1 Cheung C.L....Kung A.W. (Hum. Mol. Genet. 2009)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    10. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)2 Matsuoka S.... Elledge S.J. (Science 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 92342 HGNC: 28793 AceView: MGC9084 Ensembl:ENSG00000171806 euGenes: HUgn92342
    ECgene: METTL18 H-InvDB: METTL18

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for METTL18 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for METTL18 gene:
    Search GeneIP for patents involving METTL18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for METTL18  
     OriGene qPCR primer pairs and template standards for METTL18   OriGene Protein Over-expression Lysate for METTL18  
     OriGene MassSpec something-or-other for METTL18   OriGene clones in human, mouse for METTL18  
     OriGene qSTAR qPCR primer pairs in human, mouse for METTL18   OriGene Purified Protein for METTL18  
     OriGene ORF clones in mouse, rat for METTL18   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for METTL18   OriGene Custom Protein Services for METTL18  

     
     
     Block miRNA regulation of human, mouse, rat METTL18 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing METTL18
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat METTL18 Predesigned siRNA for gene silencing in human, mouse, rat METTL18
     QuantiFast Probe-based Assays in human, mouse, rat METTL18 QuantiTect SYBR Green Assays in human, mouse, rat METTL18
     Custom PCR Arrays for METTL18 Search Chromatin IP Primers for METTL18
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat METTL18  Search GeneGlobe Interaction Network for METTL18
     Search Regulatory tfbs for METTL18
     GenScript Custom Purified and Recombinant Proteins Services for METTL18 GenScript cDNA clones with any tag delivered in your preferred vector for METTL18
     GenScript Custom Assay Services for METTL18 GenScript Custom overexpressing Cell Line Services for METTL18
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for METTL18 (MET18)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     METTL18 antibodies
     METTL18 lysates
     Antibodies for METTL18
     See all of Abcam's Antibodies, Kits and Proteins for METTL18
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for METTL18
     Antibodies for METTL18
     ELISAs for METTL18
     CLIAs for METTL18



     Browse ESI BIO Cell Lines and PureStem Progenitors for METTL18
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL18
     Browse SwitchGear 3'UTR luciferase reporter plasmids for METTL18
     Browse SwitchGear Promoter luciferase reporter plasmids for METTL18
     Search ThermoFisher Antibodies for METTL18
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL18
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for METTL18
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for METTL18
     Search LSBio for Antibodies for METTL18
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      METTL18 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4