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Aliases for METTL18 Gene

Aliases for METTL18 Gene

  • Methyltransferase Like 18 2 3 5
  • Methyltransferase-Like Protein 18 3 4
  • Arsenic-Transactivated Protein 2 3 4
  • C1orf156 3 4
  • AsTP2 3 4
  • Histidine Protein Methyltransferase 1 Homolog 3
  • Histidine Protein Methyltransferase 1 2
  • Chromosome 1 Open Reading Frame 156 2
  • EC 2.1.1.- 4
  • HPM1 3

External Ids for METTL18 Gene

Previous HGNC Symbols for METTL18 Gene

  • C1orf156

Summaries for METTL18 Gene

GeneCards Summary for METTL18 Gene

METTL18 (Methyltransferase Like 18) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity and protein methyltransferase activity.

UniProtKB/Swiss-Prot for METTL18 Gene

  • Probable histidine methyltransferase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL18 Gene

Genomics for METTL18 Gene

Regulatory Elements for METTL18 Gene

Enhancers for METTL18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F169889 1.8 FANTOM5 Ensembl ENCODE 41.8 -97.3 -97271 5.5 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 METTL18 KIFAP3 MRPS10P1 ENSG00000230704 ENSG00000232959 HAUS4P1 RPL29P7 GORAB SCYL3 C1orf112
GH01F169688 1.4 FANTOM5 Ensembl ENCODE 42 +97.9 97916 17.5 YBX3 CTCF PKNOX1 ZNF146 EBF1 RAD21 ZNF316 GATA3 POLR2A EED METTL18 C1orf112 SELP F5 DPT SELL SCYL3 KIFAP3 ENSG00000230704 METTL11B
GH01F169941 1.4 VISTA Ensembl 38.8 -147.6 -147631 2.7 PKNOX1 INSM2 ZNF76 FEZF1 ZNF2 ZNF121 ZNF366 SCRT2 KLF7 ZNF391 METTL18 NME7 GC01P169942 GC01M169872
GH01F169793 1.1 ENCODE 46.3 -0.1 -98 2.3 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 DEK METTL18 SCYL3 GORAB C1orf112 KIFAP3 RN7SL333P
GH01F170072 1.3 FANTOM5 ENCODE 37.4 -279.3 -279267 2.6 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 DEK METTL18 KIFAP3 C1orf112 LOC105371608
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around METTL18 on UCSC Golden Path with GeneCards custom track

Promoters for METTL18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000671455 -34 2401 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 DEK

Genomic Location for METTL18 Gene

169,792,529 bp from pter
169,794,966 bp from pter
2,438 bases
Minus strand

Genomic View for METTL18 Gene

Genes around METTL18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL18 Gene

Proteins for METTL18 Gene

  • Protein details for METTL18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Histidine protein methyltransferase 1 homolog
    Protein Accession:
    Secondary Accessions:
    • B2R9T5

    Protein attributes for METTL18 Gene

    372 amino acids
    Molecular mass:
    42148 Da
    Quaternary structure:
    • Interacts with GRWD1, RPL3 and members of the heat shock protein 90 and 70 families; these proteins may possibly be methylation substrates for the enzyme.

    Three dimensional structures from OCA and Proteopedia for METTL18 Gene

neXtProt entry for METTL18 Gene

Post-translational modifications for METTL18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for METTL18 Gene

No data available for DME Specific Peptides for METTL18 Gene

Domains & Families for METTL18 Gene

Gene Families for METTL18 Gene

Protein Domains for METTL18 Gene


Suggested Antigen Peptide Sequences for METTL18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the methyltransferase superfamily. METTL18 family.
  • Belongs to the methyltransferase superfamily. METTL18 family.
genes like me logo Genes that share domains with METTL18: view

Function for METTL18 Gene

Molecular function for METTL18 Gene

UniProtKB/Swiss-Prot Function:
Probable histidine methyltransferase.

Enzyme Numbers (IUBMB) for METTL18 Gene

Gene Ontology (GO) - Molecular Function for METTL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with METTL18: view
genes like me logo Genes that share phenotypes with METTL18: view

Animal Model Products

miRNA for METTL18 Gene

miRTarBase miRNAs that target METTL18

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL18 Gene

Localization for METTL18 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL18 gene
Compartment Confidence
cytosol 3
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for METTL18 Gene

Pathways & Interactions for METTL18 Gene

SuperPathways for METTL18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for METTL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL18: view

No data available for Pathways by source and SIGNOR curated interactions for METTL18 Gene

Transcripts for METTL18 Gene

Unigene Clusters for METTL18 Gene

Methyltransferase like 18:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL18 Gene

No ASD Table

Relevant External Links for METTL18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for METTL18 Gene

Protein differential expression in normal tissues from HIPED for METTL18 Gene

This gene is overexpressed in Lung (20.9), Spleen (13.0), Heart (12.1), and CD4 Tcells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for METTL18 Gene

Protein tissue co-expression partners for METTL18 Gene

NURSA nuclear receptor signaling pathways regulating expression of METTL18 Gene:


SOURCE GeneReport for Unigene cluster for METTL18 Gene:

genes like me logo Genes that share expression patterns with METTL18: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for METTL18 Gene

Orthologs for METTL18 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METTL18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia METTL18 34 35
  • 99.73 (n)
(Canis familiaris)
Mammalia METTL18 34 35
  • 88.28 (n)
(Bos Taurus)
Mammalia METTL18 34 35
  • 87.15 (n)
(Rattus norvegicus)
Mammalia Mettl18 34
  • 79.44 (n)
(Mus musculus)
Mammalia Mettl18 34 16 35
  • 77.69 (n)
(Monodelphis domestica)
Mammalia METTL18 35
  • 62 (a)
(Gallus gallus)
Aves METTL18 34
  • 65.69 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl18 34
  • 56.67 (n)
Str.10924 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.15802 34
(Danio rerio)
Actinopterygii LOC796750 34
  • 56.01 (n)
METTL18 35
  • 44 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17219 34 35
  • 51.69 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009532 34
  • 50.92 (n)
(Caenorhabditis elegans)
Secernentea K01A11.2 34 35
  • 52.49 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HPM1 35 37
  • 24 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G14000 34
  • 47.25 (n)
(Oryza sativa)
Liliopsida Os09g0359900 34
  • 49.34 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 32 (a)
Species where no ortholog for METTL18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL18 Gene

Gene Tree for METTL18 (if available)
Gene Tree for METTL18 (if available)

Paralogs for METTL18 Gene

No data available for Paralogs for METTL18 Gene

Variants for METTL18 Gene

Sequence variations from dbSNP and Humsavar for METTL18 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10489177 -- 169,793,666(-) ATAGA(A/C)GACCA upstream-variant-2KB, reference, missense
rs10919245 -- 169,793,998(+) CTCCC(C/T)GTCCC intron-variant, upstream-variant-2KB
rs10919246 -- 169,795,911(+) TCGTC(C/G)GGGTG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs111419588 -- 169,793,907(+) AAAGA(A/G)AAAAA intron-variant, upstream-variant-2KB
rs111464440 -- 169,792,376(+) AGGAG(A/G)TCTCA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for METTL18 Gene

Variant ID Type Subtype PubMed ID
nsv1078878 OTHER inversion 25765185

Variation tolerance for METTL18 Gene

Residual Variation Intolerance Score: 65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.11; 84.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for METTL18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL18 Gene

Disorders for METTL18 Gene

Relevant External Links for METTL18

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for METTL18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL18 Gene

Publications for METTL18 Gene

  1. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P. … Coulombe B. (PLoS Genet. 2013) 3 4 64
  2. A novel 3-methylhistidine modification of yeast ribosomal protein Rpl3 is dependent upon the YIL110W methyltransferase. (PMID: 20864530) Webb K.J. … Clarke S.G. (J. Biol. Chem. 2010) 2 3 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for METTL18 Gene

Sources for METTL18 Gene

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