METTL18 Gene
protein-coding GIFtS: 43
GCID: GC01M169762
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methyltransferase like 18(Previous name: chromosome 1 open reading frame 156 )
(Previous symbol: C1orf156)
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Aliases
for METTL18 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Methyltransferase Like 181 2 | | MGC90841 | | AsTP21 2 3 | | Chromosome 1 Open Reading Frame 1561 | | C1orf1561 2 3 | | Histidine Protein Methyltransferase 1 Homolog2 | | HPM11 2 | | ASTP23 | | Arsenic-Transactivated Protein 22 3 | | EC 2.1.1.-3 | | Methyltransferase-Like Protein 182 3 | | |
Export aliases for METTL18 gene to outside databases |
Summaries
for METTL18 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MET18_HUMAN, O95568Function: Probable histidine methyltransferase (By similarity)
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Genomic Views
for METTL18 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for METTL18
Other transcription factors
Search SABiosciences Chromatin IP Primers for METTL18
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL18 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q24.2 Ensembl cytogenetic band: 1q24.2 HGNC cytogenetic band: 1q24.2METTL18 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M169762: view genomic region
(about GC identifiers)
Start:
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169,761,670 bp from pter |
End:
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169,764,107 bp from pter |
Size:
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2,438 bases |
Orientation:
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minus strand |
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Proteins
for METTL18 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MET18_HUMAN, O95568 (See
protein sequence)Recommended Name: Histidine protein methyltransferase 1 homolog Size: 372 amino acids; 42148 Da
Secondary accessions: B2R9T5Explore the universe of human proteins at neXtProt for METTL18: NX_O95568
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95568
METTL18 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_219486.1
ENSEMBL proteins: ENSP00000307975 ENSP00000307077 ENSP00000402305
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
METTL18 for ontologies About GeneDecksing
METTL18 Antibody Products:
Assay Products for METTL18: |
Protein
Domains /
Families
for METTL18 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
METTL18 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O95568ProtoNet protein and cluster: O95568 UniProtKB/Swiss-Prot: MET18_HUMAN, O95568Similarity: Belongs to the methyltransferase superfamily. METTL18 family |
Function
for METTL18 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MET18_HUMAN, O95568Function: Probable histidine methyltransferase (By similarity)Enzyme Number (IUBMB): EC 2.1.1.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL18 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL18 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: METTL18 (NM_033418) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for METTL18 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL18 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL18 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008276 | protein methyltransferase activity |
IEA | -- |
METTL18 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for METTL18:
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Pathways & Interactions
for METTL18 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for METTL18
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/6 Interacting proteins for METTL18 (O955682, 3 ENSP000003070774) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
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Drugs & Compounds
for METTL18 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for METTL18
Search CenterWatch for drugs/clinical trials and news about METTL18 / MET18
|
Transcripts
for METTL18 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for METTL18 gene: NM_033418.2 Unigene Clusters for METTL18: Methyltransferase like 18 Hs.33922 [show with all ESTs], Hs.743446 [show with all ESTs]Unigene Representative Sequences: AY744366, NM_0334183 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000310392(uc001ggn.3) ENST00000303469 ENST00000454472
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL18 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL18 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: METTL18 (NM_033418) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for METTL18 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL18 |
Additional cDNA sequence: AK313909.1 AL035369.1 BC008679.1 4 DOTS entries: DT.314364 DT.100744152 DT.91757156 DT.121415911 24/72 AceView cDNA sequences (see all 72): AI337857 BF111615 AI492439 N71424 CR602834 CB112786 BQ016169 BU631100 NM_033418 AL035369 BM702845 AA830352 CR450330 CR609500 AL556604 AA905464 CR600232 BC008679 AI051822 BP378272 BE873293 AI287532 AW615333 AA491197
GeneLoc Exon Structure
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Expression
for METTL18 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| METTL18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTAAGTTATC
About this image
See METTL18 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for METTL18
SOURCE GeneReport for Unigene clusters: Hs.33922 Hs.743446
SABiosciences Custom PCR Arrays for METTL18
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for METTL18
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat METTL18 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL18 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL18 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL18 |
Orthologs
for METTL18 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for METTL18 gene from 8/27 species (see all 27) About this table
ENSEMBL Gene Tree for METTL18 (if available)
TreeFam Gene Tree for METTL18 (if available) |
Paralogs
for METTL18 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for METTL18 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for METTL18 (169761670 - 169764107 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for METTL18: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing METTL18 |
|
Disorders
/ Diseases
for METTL18 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
METTL18 for disorders About GeneDecksing
5  diseases for METTL18: About MalaCardsessential hypertension hypertension t-cell leukemia leukemia
malaria
Export disorders for METTL18 gene to outside databases
|
Publications
for METTL18 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for METTL18 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with METTL18) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel 3-methylhistidine modification of yeast ribos omal protein Rpl3 is dependent upon the YIL110W methyltransferase. (PubMed id 20864530)1, 3 Webb K.J....Clarke S.G. (2010)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Follow-up of a major linkage peak on chromosome 1 rev eals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1 Ehret G.B....Chakravarti A. (2009)
- Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PubMed id 19064610)1 Cheung C.L....Kung A.W. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)2 Matsuoka S.... Elledge S.J. (2007)
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External Searches for METTL18 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing METTL18 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing METTL18 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing METTL18 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for METTL18 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for METTL18 gene:
Search GeneIP for patents involving METTL18
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for METTL18 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for METTL18 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for METTL18 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for METTL18 | | | OriGene Protein Over-expression Lysate for METTL18 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL18 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL18 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for METTL18 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for METTL18 | | OriGene Custom Protein Services for METTL18 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat METTL18 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing METTL18 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL18 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat METTL18 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL18 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL18 |
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 |  |  |  | |
| | | | Search Tocris compounds for METTL18 |
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 | | | METTL18 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL18 |
|  |  |  | | | | Search ThermoFisher Antibodies for METTL18 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL18 |
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