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Aliases for METTL18 Gene

Aliases for METTL18 Gene

  • Methyltransferase Like 18 2 3
  • Methyltransferase-Like Protein 18 3 4
  • Arsenic-Transactivated Protein 2 3 4
  • C1orf156 3 4
  • AsTP2 3 4
  • Histidine Protein Methyltransferase 1 2
  • Chromosome 1 Open Reading Frame 156 2
  • EC 2.1.1.- 4
  • HPM1 3

External Ids for METTL18 Gene

Previous HGNC Symbols for METTL18 Gene

  • C1orf156

Summaries for METTL18 Gene

GeneCards Summary for METTL18 Gene

METTL18 (Methyltransferase Like 18) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity and protein methyltransferase activity.

UniProtKB/Swiss-Prot for METTL18 Gene

  • Probable histidine methyltransferase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL18 Gene

Genomics for METTL18 Gene

Genomic Location for METTL18 Gene

169,792,529 bp from pter
169,794,966 bp from pter
2,438 bases
Minus strand

Genomic View for METTL18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for METTL18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL18 Gene

No data available for Regulatory Elements for METTL18 Gene

Proteins for METTL18 Gene

  • Protein details for METTL18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Histidine protein methyltransferase 1 homolog
    Protein Accession:
    Secondary Accessions:
    • B2R9T5

    Protein attributes for METTL18 Gene

    372 amino acids
    Molecular mass:
    42148 Da
    Quaternary structure:
    • Interacts with GRWD1, RPL3 and members of the heat shock protein 90 and 70 families; these proteins may possibly be methylation substrates for the enzyme.

    Three dimensional structures from OCA and Proteopedia for METTL18 Gene

neXtProt entry for METTL18 Gene

Proteomics data for METTL18 Gene at MOPED

Post-translational modifications for METTL18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for METTL18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for METTL18 Gene

Domains & Families for METTL18 Gene

Gene Families for METTL18 Gene

Protein Domains for METTL18 Gene


Suggested Antigen Peptide Sequences for METTL18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the methyltransferase superfamily. METTL18 family.
  • Belongs to the methyltransferase superfamily. METTL18 family.
genes like me logo Genes that share domains with METTL18: view

Function for METTL18 Gene

Molecular function for METTL18 Gene

UniProtKB/Swiss-Prot Function:
Probable histidine methyltransferase.

Enzyme Numbers (IUBMB) for METTL18 Gene

Gene Ontology (GO) - Molecular Function for METTL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with METTL18: view
genes like me logo Genes that share phenotypes with METTL18: view

Animal Model Products

CRISPR Products

miRNA for METTL18 Gene

miRTarBase miRNAs that target METTL18

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for METTL18

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for METTL18 Gene

Localization for METTL18 Gene

Subcellular locations from

Jensen Localization Image for METTL18 Gene COMPARTMENTS Subcellular localization image for METTL18 gene
Compartment Confidence
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for METTL18 Gene

Pathways & Interactions for METTL18 Gene

SuperPathways for METTL18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for METTL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL18: view

No data available for Pathways by source and SIGNOR curated interactions for METTL18 Gene

Drugs & Compounds for METTL18 Gene

No Compound Related Data Available

Transcripts for METTL18 Gene

Unigene Clusters for METTL18 Gene

Methyltransferase like 18:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for METTL18

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL18 Gene

No ASD Table

Relevant External Links for METTL18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL18 Gene

mRNA expression in normal human tissues for METTL18 Gene

Protein differential expression in normal tissues from HIPED for METTL18 Gene

This gene is overexpressed in Lung (20.9), Spleen (13.0), Heart (12.1), and CD4 Tcells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for METTL18 Gene

SOURCE GeneReport for Unigene cluster for METTL18 Gene Hs.33922

genes like me logo Genes that share expression patterns with METTL18: view

Protein tissue co-expression partners for METTL18 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for METTL18 Gene

Orthologs for METTL18 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METTL18 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia METTL18 35
  • 87.15 (n)
  • 81.94 (a)
METTL18 36
  • 82 (a)
(Canis familiaris)
Mammalia METTL18 35
  • 88.28 (n)
  • 83.24 (a)
METTL18 36
  • 83 (a)
(Mus musculus)
Mammalia Mettl18 35
  • 77.69 (n)
  • 71.67 (a)
Mettl18 16
Mettl18 36
  • 71 (a)
(Pan troglodytes)
Mammalia METTL18 35
  • 99.73 (n)
  • 99.73 (a)
METTL18 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mettl18 35
  • 79.44 (n)
  • 72.78 (a)
(Monodelphis domestica)
Mammalia METTL18 36
  • 62 (a)
(Gallus gallus)
Aves METTL18 35
  • 65.69 (n)
  • 61.76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl18 35
  • 56.67 (n)
  • 49.17 (a)
Str.10924 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15802 35
(Danio rerio)
Actinopterygii LOC796750 35
  • 56.01 (n)
  • 51.67 (a)
METTL18 36
  • 44 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009532 35
  • 50.92 (n)
  • 46.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17219 35
  • 51.69 (n)
  • 48.79 (a)
CG17219 36
  • 38 (a)
(Caenorhabditis elegans)
Secernentea K01A11.2 35
  • 52.49 (n)
  • 44.75 (a)
K01A11.2 36
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HPM1 36
  • 24 (a)
HPM1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G14000 35
  • 47.25 (n)
  • 39.91 (a)
(Oryza sativa)
Liliopsida Os09g0359900 35
  • 49.34 (n)
  • 40.1 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
Species with no ortholog for METTL18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL18 Gene

Gene Tree for METTL18 (if available)
Gene Tree for METTL18 (if available)

Paralogs for METTL18 Gene

No data available for Paralogs for METTL18 Gene

Variants for METTL18 Gene

Sequence variations from dbSNP and Humsavar for METTL18 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1801567 -- 169,792,708(-) TTGGT(G/T)TAGGT reference, missense
rs12116650 -- 169,792,476(+) ACAAA(A/C)AACAT downstream-variant-500B
rs12135361 -- 169,792,450(+) CTTAC(A/G)ATTTG downstream-variant-500B
rs12136126 -- 169,792,548(+) GTTTA(C/T)TTCAT utr-variant-3-prime
rs12145574 -- 169,792,229(+) ACTAA(C/T)GAAGA downstream-variant-500B

Variation tolerance for METTL18 Gene

Residual Variation Intolerance Score: 65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.11; 84.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for METTL18 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for METTL18 Gene

Disorders for METTL18 Gene

Relevant External Links for METTL18

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with METTL18: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL18 Gene

Publications for METTL18 Gene

  1. A novel 3-methylhistidine modification of yeast ribosomal protein Rpl3 is dependent upon the YIL110W methyltransferase. (PMID: 20864530) Webb K.J. … Clarke S.G. (J. Biol. Chem. 2010) 2 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  3. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P. … Coulombe B. (PLoS Genet. 2013) 67
  4. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 67
  5. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret G.B. … Chakravarti A. (Eur. J. Hum. Genet. 2009) 67

Products for METTL18 Gene

Sources for METTL18 Gene

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