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Aliases for METTL17 Gene

Aliases for METTL17 Gene

  • Methyltransferase Like 17 2 3 5
  • Methyltransferase 11 Domain-Containing Protein 1 3 4
  • Methyltransferase 11 Domain Containing 1 2 3
  • Protein RSM22 Homolog, Mitochondrial 3 4
  • False P73 Target Gene Protein 3 4
  • METT11D1 3 4
  • Methyltransferase-Like Protein 17, Mitochondrial 3
  • EC 2.1.1.- 4

External Ids for METTL17 Gene

Previous HGNC Symbols for METTL17 Gene

  • METT11D1

Previous GeneCards Identifiers for METTL17 Gene

  • GC14P021458
  • GC14P021028
  • GC14P021040
  • GC14P021047
  • GC14P021053
  • GC14P021065
  • GC14P021073

Summaries for METTL17 Gene

GeneCards Summary for METTL17 Gene

METTL17 (Methyltransferase Like 17) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity and copper ion binding.

UniProtKB/Swiss-Prot for METTL17 Gene

  • May be a component of the mitochondrial small ribosomal subunit.

Additional gene information for METTL17 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL17 Gene

Genomics for METTL17 Gene

Regulatory Elements for METTL17 Gene

Enhancers for METTL17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H020657 1.3 Ensembl ENCODE 65.9 -332.0 -332043 1 HDGF PKNOX1 SIN3A GLI4 ZNF2 GTF3C2 GLIS2 FOS KLF7 ZNF548 METTL3 SUPT16H METTL17 ENSG00000258515 CHD8 TEP1 ENSG00000258768 TTC5 PARP2 PIP4P1
GH14H021092 2 FANTOM5 Ensembl ENCODE dbSUPER 41.8 +111.7 111657 18 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A SSRP1 METTL3 SUPT16H CHD8 METTL17 APEX1 PNP TEP1 ARHGEF40 TOX4 SNORA79B
GH14H020453 1.2 ENCODE 66.9 -534.2 -534228 3 HDGF PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B SUPT16H METTL17 OSGEP ENSG00000258515 APEX1 TEP1 PIP4P1 ZNF219 RNASE9 RNASE12
GH14H020622 1.3 Ensembl ENCODE 42.2 -365.0 -365022 3 HNRNPUL1 SIN3A FEZF1 ZNF2 ZNF143 FOS ZC3H11A ZNF592 SSRP1 ZNF610 METTL3 SUPT16H CHD8 PARP2 METTL17 ENSG00000258515 TEP1 ENSG00000258768 OSGEP TOX4
GH14H020612 1.4 Ensembl ENCODE 34.5 -376.1 -376064 3 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B METTL3 SUPT16H ENSG00000258515 CHD8 METTL17 PARP2 ENSG00000258768 OSGEP TTC5 PIP4P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around METTL17 on UCSC Golden Path with GeneCards custom track

Promoters for METTL17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000066428 330 1401 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 FOS SP3

Genomic Location for METTL17 Gene

Chromosome:
14
Start:
20,989,770 bp from pter
End:
20,997,035 bp from pter
Size:
7,266 bases
Orientation:
Plus strand

Genomic View for METTL17 Gene

Genes around METTL17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL17 Gene

Proteins for METTL17 Gene

  • Protein details for METTL17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7H0-MET17_HUMAN
    Recommended name:
    Methyltransferase-like protein 17, mitochondrial
    Protein Accession:
    Q9H7H0
    Secondary Accessions:
    • Q9BSH1
    • Q9BZH2
    • Q9BZH3

    Protein attributes for METTL17 Gene

    Size:
    456 amino acids
    Molecular mass:
    50734 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for METTL17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for METTL17 Gene

Post-translational modifications for METTL17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for METTL17 Gene

Domains & Families for METTL17 Gene

Gene Families for METTL17 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for METTL17 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H7H0

UniProtKB/Swiss-Prot:

MET17_HUMAN :
  • Belongs to the methyltransferase superfamily. Rsm22 family.
Family:
  • Belongs to the methyltransferase superfamily. Rsm22 family.
genes like me logo Genes that share domains with METTL17: view

Function for METTL17 Gene

Molecular function for METTL17 Gene

UniProtKB/Swiss-Prot Function:
May be a component of the mitochondrial small ribosomal subunit.

Enzyme Numbers (IUBMB) for METTL17 Gene

Phenotypes From GWAS Catalog for METTL17 Gene

Gene Ontology (GO) - Molecular Function for METTL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16713569
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with METTL17: view

Phenotypes for METTL17 Gene

genes like me logo Genes that share phenotypes with METTL17: view

Animal Model Products

  • Taconic Biosciences Mouse Models for METTL17

CRISPR Products

miRNA for METTL17 Gene

miRTarBase miRNAs that target METTL17

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for METTL17
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL17 Gene

Localization for METTL17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL17 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL17 gene
Compartment Confidence
mitochondrion 3
nucleus 3
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for METTL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005840 ribosome IEA --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with METTL17: view

Pathways & Interactions for METTL17 Gene

SuperPathways for METTL17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for METTL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL17: view

No data available for Pathways by source and SIGNOR curated interactions for METTL17 Gene

Drugs & Compounds for METTL17 Gene

No Compound Related Data Available

Transcripts for METTL17 Gene

Unigene Clusters for METTL17 Gene

Methyltransferase like 17:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for METTL17
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for METTL17 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - -
SP6: - - - - - -
SP7: - - -
SP8: - - - -
SP9: - - - - - - - - - - - - - - - - -
SP10: - - -
SP11: - - - - - -
SP12: - - - - -
SP13:
SP14: - - - - - - - - - - - - - -
SP15: - -
SP16: - - -
SP17: - - -
SP18:
SP19:
SP20:
SP21:

ExUns: 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c · 14d ^ 15a · 15b · 15c · 15d · 15e
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9: - - - - - - - -
SP10:
SP11:
SP12:
SP13: -
SP14: - - - - - - -
SP15:
SP16:
SP17:
SP18:
SP19:
SP20: -
SP21:

Relevant External Links for METTL17 Gene

GeneLoc Exon Structure for
METTL17
ECgene alternative splicing isoforms for
METTL17

Expression for METTL17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for METTL17 Gene

Protein differential expression in normal tissues from HIPED for METTL17 Gene

This gene is overexpressed in Adipocyte (28.5) and Lung (24.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for METTL17 Gene



NURSA nuclear receptor signaling pathways regulating expression of METTL17 Gene:

METTL17

SOURCE GeneReport for Unigene cluster for METTL17 Gene:

Hs.512693

Evidence on tissue expression from TISSUES for METTL17 Gene

  • Lung(4.4)
  • Nervous system(3.8)
genes like me logo Genes that share expression patterns with METTL17: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL17 Gene

Orthologs for METTL17 Gene

This gene was present in the common ancestor of animals.

Orthologs for METTL17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL17 33 34
  • 99.42 (n)
cow
(Bos Taurus)
Mammalia METTL17 33 34
  • 85.7 (n)
dog
(Canis familiaris)
Mammalia METTL17 33 34
  • 84.74 (n)
mouse
(Mus musculus)
Mammalia Mettl17 33 16 34
  • 82.89 (n)
rat
(Rattus norvegicus)
Mammalia Mettl17 33
  • 82.53 (n)
oppossum
(Monodelphis domestica)
Mammalia METTL17 34
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 64 (a)
OneToMany
-- 34
  • 52 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia METTL17 34
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl17 33
  • 61.15 (n)
zebrafish
(Danio rerio)
Actinopterygii mettl17 33 34
  • 56.28 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6407 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002734 33
  • 44.68 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13126 33 34
  • 44.11 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_F32A7.4 33
  • 44.23 (n)
F32A7.4 34
  • 22 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
OneToOne
Species where no ortholog for METTL17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL17 Gene

ENSEMBL:
Gene Tree for METTL17 (if available)
TreeFam:
Gene Tree for METTL17 (if available)

Paralogs for METTL17 Gene

No data available for Paralogs for METTL17 Gene

Variants for METTL17 Gene

Sequence variations from dbSNP and Humsavar for METTL17 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000185701 -- 20,992,853(+) CTGTA(A/C)TCCAG intron-variant
rs1000317830 -- 20,993,782(+) CTACC(-/T)TTTTT intron-variant
rs1000544424 -- 20,988,754(+) CTCCC(C/T)CTGTC upstream-variant-2KB
rs1000662131 -- 20,992,437(+) GGCCT(A/G)AGCTG intron-variant
rs1001307849 -- 20,988,179(+) TTTGG(A/T)GCCGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for METTL17 Gene

Variant ID Type Subtype PubMed ID
esv2759972 CNV gain+loss 17122850
nsv428293 CNV gain+loss 18775914
nsv470622 CNV loss 18288195
nsv563847 CNV loss 21841781
nsv832740 CNV gain 17160897

Variation tolerance for METTL17 Gene

Residual Variation Intolerance Score: 63.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.47; 64.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for METTL17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
METTL17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL17 Gene

Disorders for METTL17 Gene

Relevant External Links for METTL17

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
METTL17

No disorders were found for METTL17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL17 Gene

Publications for METTL17 Gene

  1. Identification of 12 new yeast mitochondrial ribosomal proteins including 6 that have no prokaryotic homologues. (PMID: 11278769) Saveanu C … Jacquier A (The Journal of biological chemistry 2001) 2 3 4 60
  2. Methyltransferase-like 17 physically and functionally interacts with estrogen receptors. (PMID: 26488768) Du P … Ye Q (IUBMB life 2015) 2 3 60
  3. Sequence variants in four candidate genes (NIPSNAP1, GBAS, CHCHD1 and METT11D1) in patients with combined oxidative phosphorylation system deficiencies. (PMID: 24137763) Smits P … van den Heuvel LP (Journal of inherited metabolic disease 2010) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3 60

Products for METTL17 Gene

Sources for METTL17 Gene

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