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Aliases for METTL17 Gene

Aliases for METTL17 Gene

  • Methyltransferase Like 17 2 3
  • Methyltransferase 11 Domain-Containing Protein 1 3 4
  • Methyltransferase 11 Domain Containing 1 2 3
  • Protein RSM22 Homolog, Mitochondrial 3 4
  • False P73 Target Gene Protein 3 4
  • METT11D1 3 4
  • Methyltransferase-Like Protein 17, Mitochondrial 3
  • EC 2.1.1.- 4

External Ids for METTL17 Gene

Previous Symbols for METTL17 Gene

  • METT11D1

Summaries for METTL17 Gene

GeneCards Summary for METTL17 Gene

METTL17 (Methyltransferase Like 17) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity and copper ion binding.

UniProtKB/Swiss-Prot for METTL17 Gene

  • May be a component of the mitochondrial small ribosomal subunit.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL17 Gene

Genomics for METTL17 Gene

Genomic Location for METTL17 Gene

Start:
20,989,770 bp from pter
End:
20,997,035 bp from pter
Size:
7,266 bases
Orientation:
Plus strand

Genomic View for METTL17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for METTL17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL17 Gene

No data available for Regulatory Elements for METTL17 Gene

Proteins for METTL17 Gene

  • Protein details for METTL17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7H0-MET17_HUMAN
    Recommended name:
    Methyltransferase-like protein 17, mitochondrial
    Protein Accession:
    Q9H7H0
    Secondary Accessions:
    • Q9BSH1
    • Q9BZH2
    • Q9BZH3

    Protein attributes for METTL17 Gene

    Size:
    456 amino acids
    Molecular mass:
    50734 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for METTL17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for METTL17 Gene

Proteomics data for METTL17 Gene at MOPED

Post-translational modifications for METTL17 Gene

No Post-translational modifications

No data available for DME Specific Peptides for METTL17 Gene

Domains for METTL17 Gene

Protein Domains for METTL17 Gene

UniProtKB/Swiss-Prot:

MET17_HUMAN
Family:
  • Belongs to the methyltransferase superfamily. Rsm22 family.:
    • Q9H7H0
genes like me logo Genes that share domains with METTL17: view

No data available for Gene Families for METTL17 Gene

Function for METTL17 Gene

Molecular function for METTL17 Gene

UniProtKB/Swiss-Prot Function: May be a component of the mitochondrial small ribosomal subunit.

Enzyme Numbers (IUBMB) for METTL17 Gene

Gene Ontology (GO) - Molecular Function for METTL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005507 copper ion binding IEA --
GO:0005515 protein binding IPI 16713569
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with METTL17: view

miRNA for METTL17 Gene

miRTarBase miRNAs that target METTL17

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for METTL17 Gene

Localization for METTL17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL17 Gene

Mitochondrion.

Gene Ontology (GO) - Cellular Components for METTL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with METTL17: view

Pathways for METTL17 Gene

SuperPathways for METTL17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for METTL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0008152 metabolic process --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL17: view

No data available for Pathways by source for METTL17 Gene

Transcripts for METTL17 Gene

Unigene Clusters for METTL17 Gene

Methyltransferase like 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for METTL17 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - -
SP6: - - - - - -
SP7: - - -
SP8: - - - -
SP9: - - - - - - - - - - - - - - - - -
SP10: - - -
SP11: - - - - - -
SP12: - - - - -
SP13:
SP14: - - - - - - - - - - - - - -
SP15: - -
SP16: - - -
SP17: - - -
SP18:
SP19:
SP20:
SP21:

ExUns: 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c · 14d ^ 15a · 15b · 15c · 15d · 15e
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9: - - - - - - - -
SP10:
SP11:
SP12:
SP13: -
SP14: - - - - - - -
SP15:
SP16:
SP17:
SP18:
SP19:
SP20: -
SP21:

Relevant External Links for METTL17 Gene

GeneLoc Exon Structure for
METTL17
ECgene alternative splicing isoforms for
METTL17

Expression for METTL17 Gene

mRNA expression in normal human tissues for METTL17 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for METTL17 Gene

SOURCE GeneReport for Unigene cluster for METTL17 Gene Hs.512693

genes like me logo Genes that share expressions with METTL17: view

Orthologs for METTL17 Gene

This gene was present in the common ancestor of animals.

Orthologs for METTL17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL17 36
  • 99.42 (n)
  • 99.34 (a)
METTL17 37
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia METTL17 36
  • 85.7 (n)
  • 85.56 (a)
METTL17 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia METTL17 36
  • 84.74 (n)
  • 87.95 (a)
METTL17 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mettl17 36
  • 82.89 (n)
  • 80.67 (a)
Mettl17 16
Mettl17 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia METTL17 37
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 64 (a)
OneToMany
-- 37
  • 52 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mettl17 36
  • 82.53 (n)
  • 81.94 (a)
lizard
(Anolis carolinensis)
Reptilia METTL17 37
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl17 36
  • 61.15 (n)
  • 59.91 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6407 36
zebrafish
(Danio rerio)
Actinopterygii mettl17 36
  • 56.28 (n)
  • 51.62 (a)
mettl17 37
  • 43 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002734 36
  • 44.68 (n)
  • 35.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13126 36
  • 44.11 (n)
  • 35.1 (a)
CG13126 37
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_F32A7.4 36
  • 44.23 (n)
  • 32.43 (a)
F32A7.4 37
  • 22 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 30 (a)
OneToOne
Species with no ortholog for METTL17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL17 Gene

ENSEMBL:
Gene Tree for METTL17 (if available)
TreeFam:
Gene Tree for METTL17 (if available)

Paralogs for METTL17 Gene

No data available for Paralogs for METTL17 Gene

Variants for METTL17 Gene

Sequence variations from dbSNP and Humsavar for METTL17 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs2297717 - 20,994,891(-) AATGA(C/G)CTGTC missense, reference
rs2297718 -- 20,992,419(-) CCCCA(A/G)TACAA intron-variant
rs2297719 -- 20,992,321(-) ATCCT(C/T)TTAAG intron-variant
rs2297720 -- 20,992,282(-) TTGAT(G/T)GTGTA intron-variant
rs2741729 -- 20,987,933(+) TCACT(A/C)CCATT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for METTL17 Gene

Variant ID Type Subtype PubMed ID
dgv607e1 CNV Complex 17122850
nsv428293 CNV Gain+Loss 18775914
dgv608e1 CNV Complex 17122850
nsv832740 CNV Gain 17160897
nsv470622 CNV Loss 18288195
nsv901475 CNV Gain 21882294

Relevant External Links for METTL17 Gene

HapMap Linkage Disequilibrium report
METTL17

Disorders for METTL17 Gene

No disorders were found for METTL17 Gene.

No data available for UniProtKB/Swiss-Prot for METTL17 Gene

Publications for METTL17 Gene

  1. Identification of 12 new yeast mitochondrial ribosomal proteins including 6 that have no prokaryotic homologues. (PMID: 11278769) Saveanu C. … Jacquier A. (J. Biol. Chem. 2001) 2 3 4
  2. Sequence variants in four candidate genes (NIPSNAP1, GBAS, CHCHD1 and METT11D1) in patients with combined oxidative phosphorylation system deficiencies. (PMID: 24137763) Smits P. … van den Heuvel L.P. (J. Inherit. Metab. Dis. 2010) 3 4
  3. Identification of new mechanisms of cellular response to chemotherapy by tracking changes in post-translational modifications by ubiquitin and ubiquitin-like proteins. (PMID: 24654937) Bonacci T. … Soubeyran P. (J. Proteome Res. 2014) 3
  4. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  5. A COFRADIC protocol to study protein ubiquitination. (PMID: 24816145) Stes E. … Gevaert K. (J. Proteome Res. 2014) 3

Products for METTL17 Gene

  • antibodies-online proteins for METTL17
  • antibodies-online antibodies for METTL17
  • antibodies-online kits for METTL17

Sources for METTL17 Gene

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