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Aliases for METTL17 Gene

Aliases for METTL17 Gene

  • Methyltransferase Like 17 2 3 5
  • Methyltransferase 11 Domain-Containing Protein 1 3 4
  • Methyltransferase 11 Domain Containing 1 2 3
  • Protein RSM22 Homolog, Mitochondrial 3 4
  • False P73 Target Gene Protein 3 4
  • METT11D1 3 4
  • EC 2.1.1.- 4

External Ids for METTL17 Gene

Previous HGNC Symbols for METTL17 Gene

  • METT11D1

Previous GeneCards Identifiers for METTL17 Gene

  • GC14P021458
  • GC14P021028
  • GC14P021040

Summaries for METTL17 Gene

GeneCards Summary for METTL17 Gene

METTL17 (Methyltransferase Like 17) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity and copper ion binding.

UniProtKB/Swiss-Prot for METTL17 Gene

  • May be a component of the mitochondrial small ribosomal subunit.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL17 Gene

Genomics for METTL17 Gene

Regulatory Elements for METTL17 Gene

Enhancers for METTL17 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around METTL17 on UCSC Golden Path with GeneCards custom track

Promoters for METTL17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around METTL17 on UCSC Golden Path with GeneCards custom track

Genomic Location for METTL17 Gene

Chromosome:
14
Start:
20,989,770 bp from pter
End:
20,997,035 bp from pter
Size:
7,266 bases
Orientation:
Plus strand

Genomic View for METTL17 Gene

Genes around METTL17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL17 Gene

Proteins for METTL17 Gene

  • Protein details for METTL17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7H0-MET17_HUMAN
    Recommended name:
    Methyltransferase-like protein 17, mitochondrial
    Protein Accession:
    Q9H7H0
    Secondary Accessions:
    • Q9BSH1
    • Q9BZH2
    • Q9BZH3

    Protein attributes for METTL17 Gene

    Size:
    456 amino acids
    Molecular mass:
    50734 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for METTL17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for METTL17 Gene

Proteomics data for METTL17 Gene at MOPED

Post-translational modifications for METTL17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for METTL17 Gene

Domains & Families for METTL17 Gene

Gene Families for METTL17 Gene

Protein Domains for METTL17 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H7H0

UniProtKB/Swiss-Prot:

MET17_HUMAN :
  • Belongs to the methyltransferase superfamily. Rsm22 family.
Family:
  • Belongs to the methyltransferase superfamily. Rsm22 family.
genes like me logo Genes that share domains with METTL17: view

Function for METTL17 Gene

Molecular function for METTL17 Gene

UniProtKB/Swiss-Prot Function:
May be a component of the mitochondrial small ribosomal subunit.

Enzyme Numbers (IUBMB) for METTL17 Gene

Gene Ontology (GO) - Molecular Function for METTL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with METTL17: view

Phenotypes for METTL17 Gene

GenomeRNAi human phenotypes for METTL17:
genes like me logo Genes that share phenotypes with METTL17: view

Animal Model Products

  • Taconic Biosciences Mouse Models for METTL17

CRISPR Products

miRNA for METTL17 Gene

miRTarBase miRNAs that target METTL17

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL17 Gene

Localization for METTL17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL17 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for METTL17 Gene COMPARTMENTS Subcellular localization image for METTL17 gene
Compartment Confidence
nucleus 5
mitochondrion 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for METTL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with METTL17: view

Pathways & Interactions for METTL17 Gene

SuperPathways for METTL17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for METTL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL17: view

No data available for Pathways by source and SIGNOR curated interactions for METTL17 Gene

Drugs & Compounds for METTL17 Gene

No Compound Related Data Available

Transcripts for METTL17 Gene

Unigene Clusters for METTL17 Gene

Methyltransferase like 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for METTL17 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - -
SP6: - - - - - -
SP7: - - -
SP8: - - - -
SP9: - - - - - - - - - - - - - - - - -
SP10: - - -
SP11: - - - - - -
SP12: - - - - -
SP13:
SP14: - - - - - - - - - - - - - -
SP15: - -
SP16: - - -
SP17: - - -
SP18:
SP19:
SP20:
SP21:

ExUns: 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c · 14d ^ 15a · 15b · 15c · 15d · 15e
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9: - - - - - - - -
SP10:
SP11:
SP12:
SP13: -
SP14: - - - - - - -
SP15:
SP16:
SP17:
SP18:
SP19:
SP20: -
SP21:

Relevant External Links for METTL17 Gene

GeneLoc Exon Structure for
METTL17
ECgene alternative splicing isoforms for
METTL17

Expression for METTL17 Gene

mRNA expression in normal human tissues for METTL17 Gene

Protein differential expression in normal tissues from HIPED for METTL17 Gene

This gene is overexpressed in Adipocyte (28.5) and Lung (24.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for METTL17 Gene



SOURCE GeneReport for Unigene cluster for METTL17 Gene Hs.512693

genes like me logo Genes that share expression patterns with METTL17: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for METTL17 Gene

Orthologs for METTL17 Gene

This gene was present in the common ancestor of animals.

Orthologs for METTL17 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia METTL17 35
  • 85.7 (n)
  • 85.56 (a)
METTL17 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia METTL17 35
  • 84.74 (n)
  • 87.95 (a)
METTL17 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mettl17 35
  • 82.89 (n)
  • 80.67 (a)
Mettl17 16
Mettl17 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia METTL17 35
  • 99.42 (n)
  • 99.34 (a)
METTL17 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mettl17 35
  • 82.53 (n)
  • 81.94 (a)
oppossum
(Monodelphis domestica)
Mammalia METTL17 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia METTL17 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl17 35
  • 61.15 (n)
  • 59.91 (a)
zebrafish
(Danio rerio)
Actinopterygii mettl17 35
  • 56.28 (n)
  • 51.62 (a)
mettl17 36
  • 43 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6407 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002734 35
  • 44.68 (n)
  • 35.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13126 35
  • 44.11 (n)
  • 35.1 (a)
CG13126 36
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_F32A7.4 35
  • 44.23 (n)
  • 32.43 (a)
F32A7.4 36
  • 22 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToOne
Species with no ortholog for METTL17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL17 Gene

ENSEMBL:
Gene Tree for METTL17 (if available)
TreeFam:
Gene Tree for METTL17 (if available)

Paralogs for METTL17 Gene

No data available for Paralogs for METTL17 Gene

Variants for METTL17 Gene

Sequence variations from dbSNP and Humsavar for METTL17 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs2297717 - 20,994,891(-) AATGA(C/G)CTGTC reference, missense
VAR_037423 -
VAR_072388 -
rs2741729 -- 20,987,933(+) TCACT(A/C)CCATT upstream-variant-2KB
rs2741730 -- 20,988,186(+) CCGTG(A/T)CATGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for METTL17 Gene

Variant ID Type Subtype PubMed ID
dgv607e1 CNV Complex 17122850
nsv428293 CNV Gain+Loss 18775914
dgv608e1 CNV Complex 17122850
nsv832740 CNV Gain 17160897
nsv470622 CNV Loss 18288195
nsv901475 CNV Gain 21882294

Variation tolerance for METTL17 Gene

Residual Variation Intolerance Score: 63.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.47; 64.28% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for METTL17 Gene

Disorders for METTL17 Gene

Relevant External Links for METTL17

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
METTL17

No disorders were found for METTL17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL17 Gene

Publications for METTL17 Gene

  1. Identification of 12 new yeast mitochondrial ribosomal proteins including 6 that have no prokaryotic homologues. (PMID: 11278769) Saveanu C. … Jacquier A. (J. Biol. Chem. 2001) 2 3 4 67
  2. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3

Products for METTL17 Gene

Sources for METTL17 Gene

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