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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

METTL17 Gene

protein-coding   GIFtS: 44
GCID: GC14P021458

methyltransferase like 17

(Previous name: methyltransferase 11 domain containing 1 )
(Previous symbol: METT11D1)
 Explore 2 diseases affiliated with
METTL17 via our new
 Human Malady Compendium 
Biological research products
for METTL17
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Methyltransferase Like 171 2     Protein RSM22 Homolog, Mitochondrial2 3
METT11D11 2 3     FLJ208591
Methyltransferase 11 Domain Containing 11 2     Methyltransferase-Like Protein 17, Mitochondrial2
False P73 Target Gene Protein2 3     EC 2.1.1.-3
Methyltransferase 11 Domain-Containing Protein 12 3     

External Ids:    HGNC: 192801   Entrez Gene: 647452   Ensembl: ENSG000001657927   UniProtKB: Q9H7H03   

Export aliases for METTL17 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MET17_HUMAN, Q9H7H0
Function: May be a component of the mitochondrial small ribosomal subunit (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for METTL17
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMETTL17 promoter sequence
   Search SABiosciences Chromatin IP Primers for METTL17

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

METTL17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
METTL17 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P021458:  view genomic region     (about GC identifiers)

Start:
21,457,929 bp from pter      End:
21,465,194 bp from pter
Size:
7,266 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MET17_HUMAN, Q9H7H0 (See protein sequence)
Recommended Name: Methyltransferase-like protein 17, mitochondrial precursor  
Size: 456 amino acids; 50734 Da
Subcellular location: Mitochondrion (By similarity)
Secondary accessions: Q9BSH1 Q9BZH2 Q9BZH3
Alternative splicing: 3 isoforms:  Q9H7H0-1   Q9H7H0-2   Q9H7H0-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for METTL17: NX_Q9H7H0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H7H0

  • METTL17 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001025162.1  NP_073571.1  

    ENSEMBL proteins: 
     ENSP00000343041   ENSP00000372445   ENSP00000450794   ENSP00000450782   ENSP00000450948  
     ENSP00000451478   ENSP00000452392   ENSP00000451913   ENSP00000451804   ENSP00000451049  
     ENSP00000452341   ENSP00000452238  

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    Novus Biologicals METTL17 Protein
    Novus Biologicals METTL17 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for METTL17

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005840ribosome IEA--


    METTL17 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for METTL17


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    METTL17 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR007533 Cyt_c_oxidase_assmbl_CtaG
     IPR015324 Ribosomal_Rsm22_bac-type

    Graphical View of Domain Structure for InterPro Entry Q9H7H0

    ProtoNet protein and cluster: Q9H7H0

    UniProtKB/Swiss-Prot: MET17_HUMAN, Q9H7H0
    Similarity: Belongs to the methyltransferase superfamily. Rsm22 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: MET17_HUMAN, Q9H7H0
    Function: May be a component of the mitochondrial small ribosomal subunit (By similarity)

    Enzyme Number (IUBMB): EC 2.1.1.-1

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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL17

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005507copper ion binding IEA--
    GO:0005515protein binding IPI16713569
    GO:0008168methyltransferase activity IEA--


    METTL17 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for METTL17

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/236 Interacting proteins for METTL17 (Q9H7H01, 2, 3 ENSP000003724454) via UniProtKB, MINT, STRING, and/or I2D (see all 236)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK6Q166592, 3MINT-8261439 I2D: score=2 
    ATXN1P542531, 3, ENSP000002447694EBI-948255,EBI-930964 I2D: score=3 STRING: ENSP00000244769
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    MDFIQ997503, ENSP000002303214I2D: score=5 STRING: ENSP00000230321
    LRPPRCP427042, ENSP000002606654MINT-8079030 STRING: ENSP00000260665
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation IEA--


    METTL17 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for METTL17
    Search CenterWatch for drugs/clinical trials and news about METTL17 / MET17 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for METTL17 gene (3 alternative transcripts): 
    NM_001029992.1  NM_001029991.1  NM_022734.2  

    Unigene Cluster for METTL17:

    Methyltransferase like 17
    Hs.512693  [show with all ESTs]
    Unigene Representative Sequence: NM_001029991
    18/27 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000339374(uc001vym.3 uc001vyn.3 uc001vyo.3) ENST00000554949
    ENST00000555177 ENST00000554985 ENST00000554588(uc010tlk.2) ENST00000555390
    ENST00000382985 ENST00000556670 ENST00000555640 ENST00000555533 ENST00000557701
    ENST00000556442 ENST00000553564 ENST00000557550 ENST00000554751 ENST00000554283
    ENST00000553441 ENST00000553536

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidMETTL17 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AF321002.1 AK024512.1 AK303484.1 AK304180.1 AK315999.1 BC005053.1 U56431.1 

    24 DOTS entries:

    DT.97853708  DT.92436028  DT.100887676  DT.97853707  DT.100887678  DT.120783805  DT.120783804  DT.92436042 
    DT.317466  DT.92436025  DT.98131706  DT.92436027  DT.120783783  DT.100690023  DT.100887675  DT.40106926 
    DT.100887670  DT.120783776  DT.120783813  DT.92436030  DT.95244558  DT.95244578  DT.99949322  DT.212002 

    24/343 AceView cDNA sequences (see all 343):

    BM697955 AW628315 BI823819 BG574455 BU634069 BM678879 T16904 CD251774 
    BQ649957 CR623009 BI756887 AW251054 CR593535 BG755441 BM975618 AW051335 
    BE328863 BX363151 BE675028 AI300620 BG341866 BM679593 BQ652810 BX388371 

    GeneLoc Exon Structure

    5/21 Alternative Splicing Database (ASD) splice patterns (SP) for METTL17 (see all 21)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^
    SP1:                                                              -     -     -                 -           -     -           -     -     -     -               
    SP2:                                                              -     -     -                 -           -     -           -     -     -     -               
    SP3:                                                              -     -     -                 -           -     -           -     -     -     -               
    SP4:                                                              -     -                       -           -     -           -     -     -     -               
    SP5:                                                              -     -                       -           -     -                                             

    ExUns: 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c · 14d ^ 15a · 15b · 15c · 15d · 15e
    SP1:              -     -                 -                                   -                                 
    SP2:              -     -                 -                                   -     -                           
    SP3:              -     -                 -                                                                     
    SP4:              -     -                                                                                       
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for METTL17

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    METTL17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGTGCTCAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See METTL17 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for METTL17

    SOURCE GeneReport for Unigene cluster: Hs.512693
        SABiosciences Custom PCR Arrays for METTL17
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL17

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for METTL17 gene from 7/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mettl171 , 5 methyltransferase like 171, 5 83.04(n)1
    81.03(a)1
      14 (26.71 cM)5
    525351  NM_001029990.11  NP_001025161.11 
     518848425 
    lizard
    (Anolis carolinensis)
    Reptilia METTL176
    --
    54(a)
    1 ↔ 1
    GL343220.1(1550288-1560324)
    zebrafish
    (Danio rerio)
    Actinopterygii mettl171 methyltransferase like 17 55.41(n)
    50.52(a)
      386901  XM_002660856.2  XP_002660902.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG131261 CG13126 43.77(n)
    35.1(a)
      34323  NM_135486.4  NP_609330.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_F32A7.41 Protein F32A7.4 44.14(n)
    32.16(a)
      173356  NM_061191.2  NP_493592.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G646006
    copper ion binding / methyltransferase
    18(a)
    1 ↔ 1
    1(23995971-23998720)
    rice
    (Oryza sativa)
    Liliopsida --
    expressed protein
    20(a)
    1 ↔ 1
    7(11631046-11635664)


    ENSEMBL Gene Tree for METTL17 (if available)
    TreeFam Gene Tree for METTL17 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/270 NCBI SNPs in METTL17 are shown (see all 270    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs360027491,2
    C,F--1579431(+) CCCCC-/GCCC  
            
    TAGCG
    1 -- int13Minor allele frequency- GCCC:0.34EU NA 198
    rs49813451,2
    C,F,A,H,--21455973(+) AAGCAC/TAGAAT 2 -- us2k129Minor allele frequency- T:0.35NS EA NA WA CSA 2956
    rs1901676301,2
    --21456088(+) TCATTC/TACTCC 2 -- us2k10--------
    rs27417291,2
    C,F,H,--21456092(+) TCACTC/ACCATT 2 -- us2k118Minor allele frequency- A:0.16NS EA NA WA 2342
    rs1929644881,2
    --21456168(+) GGAGTA/GCAAAC 2 -- us2k10--------
    rs1838862141,2
    --21456259(+) TCCCTC/TGGATA 2 -- us2k10--------
    rs27713411,2
    C,F,A,H,--21456306(+) GACAGC/AAAATG 2 -- us2k116Minor allele frequency- A:0.31NS EA NA WA CSA 768
    rs38113401,2
    C,F,H,--21456342(-) TGTCAC/TGGCTC 2 -- us2k1 tfbs36Minor allele frequency- T:0.05NS EA WA 628
    rs27417301,2
    C,F,A,H,--21456345(+) CCGTGA/TCATGA 2 -- us2k1 tfbs36Minor allele frequency- T:0.20NA WA EA 364
    rs27417311,2
    C,A,H,--21456346(+) CGTGAC/TATGAT 2 -- us2k1 tfbs34Minor allele frequency- T:0.19NA WA EA 360

    HapMap Linkage Disequilibrium report for METTL17 (21457929 - 21465194 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for METTL17: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    METTL17 for disorders           About GeneDecksing

    2 diseases for METTL17:    About MalaCards
    ataxia    malaria


    Export disorders for METTL17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for METTL17 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with METTL17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of 12 new yeast mitochondrial ribosomal proteins including 6 that have no prokaryotic homologues. (PubMed id 11278769)1, 2, 3 Saveanu C....Jacquier A. (2001)
    2. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    3. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    4. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
    5. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
    6. Sequence variants in four candidate genes (NIPSNAP1, GBAS, CHCHD1 and METT11D1) in patients with combined oxidative phosphorylation system deficiencies. (PubMed id 19169841)1 Smits P....van den Heuvel L.P. (2009)
    7. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    9. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
    10. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64745 HGNC: 19280 AceView: FLJ20859 Ensembl:ENSG00000165792 euGenes: HUgn64745
    ECgene: METTL17 H-InvDB: METTL17

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for METTL17 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for METTL17 gene:
    Search GeneIP for patents involving METTL17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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