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Aliases for METTL16 Gene

Aliases for METTL16 Gene

  • Methyltransferase Like 16 2 3
  • Methyltransferase 10 Domain-Containing Protein 3 4
  • Methyltransferase 10 Domain Containing 2 3
  • METT10D 3 4
  • Putative Methyltransferase METT10D 3
  • Methyltransferase-Like Protein 16 3
  • EC 2.1.1.- 4

External Ids for METTL16 Gene

Previous HGNC Symbols for METTL16 Gene

  • METT10D

Previous GeneCards Identifiers for METTL16 Gene

  • GC17M002319
  • GC17M002316

Summaries for METTL16 Gene

GeneCards Summary for METTL16 Gene

METTL16 (Methyltransferase Like 16) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity.

UniProtKB/Swiss-Prot for METTL16 Gene

  • Probable methyltransferase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL16 Gene

Genomics for METTL16 Gene

Genomic Location for METTL16 Gene

2,405,562 bp from pter
2,511,906 bp from pter
106,345 bases
Minus strand

Genomic View for METTL16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for METTL16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL16 Gene

No data available for Regulatory Elements for METTL16 Gene

Proteins for METTL16 Gene

  • Protein details for METTL16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Methyltransferase-like protein 16
    Protein Accession:
    Secondary Accessions:
    • D3DTI8
    • Q86TE5
    • Q96T16
    • Q9BVG7

    Protein attributes for METTL16 Gene

    562 amino acids
    Molecular mass:
    63621 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB55094.1; Type=Erroneous termination; Positions=505; Note=Translated as Lys.; Evidence={ECO:0000305}; Sequence=CAD89999.2; Type=Frameshift; Positions=424; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for METTL16 Gene

    Alternative splice isoforms for METTL16 Gene


neXtProt entry for METTL16 Gene

Proteomics data for METTL16 Gene at MOPED

Post-translational modifications for METTL16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for METTL16 Gene

Antibody Products

No data available for DME Specific Peptides for METTL16 Gene

Domains for METTL16 Gene

Gene Families for METTL16 Gene

Protein Domains for METTL16 Gene

Suggested Antigen Peptide Sequences for METTL16 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the methyltransferase superfamily. METTL16/RlmF family.
  • Belongs to the methyltransferase superfamily. METTL16/RlmF family.
genes like me logo Genes that share domains with METTL16: view

Function for METTL16 Gene

Molecular function for METTL16 Gene

UniProtKB/Swiss-Prot Function:
Probable methyltransferase.

Enzyme Numbers (IUBMB) for METTL16 Gene

Gene Ontology (GO) - Molecular Function for METTL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity --
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0052907 23S rRNA (adenine(1618)-N(6))-methyltransferase activity IBA --
genes like me logo Genes that share ontologies with METTL16: view

Animal Model Products

CRISPR Products

miRNA for METTL16 Gene

No data available for Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL16 Gene

Localization for METTL16 Gene

Gene Ontology (GO) - Cellular Components for METTL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with METTL16: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for METTL16 Gene

Pathways for METTL16 Gene

SuperPathways for METTL16 Gene

No Data Available

Interacting Proteins for METTL16 Gene

Gene Ontology (GO) - Biological Process for METTL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation --
GO:0070475 rRNA base methylation IBA --
genes like me logo Genes that share ontologies with METTL16: view

No data available for Pathways by source for METTL16 Gene

Transcripts for METTL16 Gene

Unigene Clusters for METTL16 Gene

Methyltransferase like 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for METTL16

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL16 Gene

No ASD Table

Relevant External Links for METTL16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL16 Gene

mRNA expression in normal human tissues for METTL16 Gene

Protein differential expression in normal tissues for METTL16 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.3) and CD8 Tcells (7.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for METTL16 Gene

SOURCE GeneReport for Unigene cluster for METTL16 Gene Hs.632237

genes like me logo Genes that share expressions with METTL16: view

Expression partners for METTL16 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for METTL16 Gene

Orthologs for METTL16 Gene

This gene was present in the common ancestor of animals.

Orthologs for METTL16 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia METTL16 35
  • 89.35 (n)
  • 91.25 (a)
-- 36
  • 75 (a)
METTL16 36
  • 91 (a)
(Canis familiaris)
Mammalia METTL16 35
  • 89.88 (n)
  • 92.86 (a)
METTL16 36
  • 93 (a)
(Mus musculus)
Mammalia Mettl16 35
  • 86.47 (n)
  • 89.49 (a)
Mettl16 16
Mettl16 36
  • 89 (a)
(Pan troglodytes)
Mammalia METTL16 35
  • 99.53 (n)
  • 99.82 (a)
METTL16 36
  • 100 (a)
(Monodelphis domestica)
Mammalia METTL16 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia METTL16 36
  • 74 (a)
(Gallus gallus)
Aves METTL16 35
  • 71.15 (n)
  • 77.02 (a)
METTL16 36
  • 77 (a)
(Anolis carolinensis)
Reptilia METTL16 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl16 35
  • 68.4 (n)
  • 75.42 (a)
Str.3947 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7647 35
(Danio rerio)
Actinopterygii mettl16 35
  • 71.84 (n)
  • 80.37 (a)
mettl16 36
  • 75 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2774 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011889 35
  • 45 (n)
  • 39.26 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7544 35
  • 51 (n)
  • 45.23 (a)
CG7544 36
  • 44 (a)
(Caenorhabditis elegans)
Secernentea mett-10 35
  • 48.71 (n)
  • 42.26 (a)
mett-10 36
  • 33 (a)
Species with no ortholog for METTL16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL16 Gene

Gene Tree for METTL16 (if available)
Gene Tree for METTL16 (if available)

Paralogs for METTL16 Gene

No data available for Paralogs for METTL16 Gene

Variants for METTL16 Gene

Sequence variations from dbSNP and Humsavar for METTL16 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs935134 -- 2,511,255(-) AAGGA(A/G)ACAGA intron-variant
rs1056321 -- 2,419,482(-) CCCAC(A/G)AAGGG utr-variant-3-prime, nc-transcript-variant
rs1545272 -- 2,490,653(+) AAAAC(A/G)GGTCC intron-variant
rs1545273 -- 2,490,658(+) AGGTC(C/T)TTGGT intron-variant
rs1545274 -- 2,490,682(+) CTCTC(C/T)GTAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for METTL16 Gene

Variant ID Type Subtype PubMed ID
nsv907532 CNV Loss 21882294
nsv833338 CNV Loss 17160897
nsv819217 CNV Loss 19587683
nsv111844 CNV Loss 16902084
nsv907538 CNV Loss 21882294
nsv907539 CNV Gain 21882294
esv2675053 CNV Deletion 23128226
esv2669015 CNV Deletion 23128226
esv22012 CNV Loss 19812545

Relevant External Links for METTL16 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL16 Gene

Disorders for METTL16 Gene

No disorders were found for METTL16 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for METTL16 Gene

Publications for METTL16 Gene

  1. The ybiN gene of Escherichia coli encodes adenine-N6 methyltransferase specific for modification of A1618 of 23 S ribosomal RNA, a methylated residue located close to the ribosomal exit tunnel. (PMID: 18021804) Sergiev P.V. … Dontsova O.A. (J. Mol. Biol. 2008) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PMID: 17643375) Jeronimo C. … Coulombe B. (Mol. Cell 2007) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for METTL16 Gene

Sources for METTL16 Gene

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