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Aliases for METTL16 Gene

Aliases for METTL16 Gene

  • Methyltransferase Like 16 2 3 5
  • Methyltransferase 10 Domain-Containing Protein 3 4
  • Methyltransferase 10 Domain Containing 2 3
  • METT10D 3 4
  • Putative Methyltransferase METT10D 3
  • Methyltransferase-Like Protein 16 3
  • EC 2.1.1.- 4

External Ids for METTL16 Gene

Previous HGNC Symbols for METTL16 Gene

  • METT10D

Previous GeneCards Identifiers for METTL16 Gene

  • GC17M002319
  • GC17M002316

Summaries for METTL16 Gene

GeneCards Summary for METTL16 Gene

METTL16 (Methyltransferase Like 16) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and 23S rRNA (adenine(1618)-N(6))-methyltransferase activity.

UniProtKB/Swiss-Prot for METTL16 Gene

  • Probable methyltransferase.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL16 Gene

Genomics for METTL16 Gene

Regulatory Elements for METTL16 Gene

Enhancers for METTL16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G002261 1.8 FANTOM5 Ensembl ENCODE dbSUPER 32.9 +246.8 246817 7.3 PKNOX1 WRNIP1 SIN3A FEZF1 ZNF2 ELK1 ZNF207 FOS ZNF263 REST SRR SMG6 HNRNPA1P16 METTL16 ENSG00000263345 TSR1 LOC101927839 HIC1 OVCA2 ENSG00000236457
GH17G002390 1.9 FANTOM5 ENCODE dbSUPER 30.3 +112.9 112895 18.6 MLX CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC METTL16 MNT SGSM2 RAP1GAP2 SMYD4 HNRNPA1P16 TSR1 RN7SL608P RPA1 ENSG00000263345
GH17G001939 0.9 ENCODE 58.6 +571.7 571716 1.6 ZNF493 ZFP64 ZNF354C ZNF202 ZNF680 ZNF426 REST ZNF398 ZNF623 ZNF518A METTL16 RPA1 SMYD4 HNRNPA1P16 RN7SL608P SMG6 ENSG00000263050 TSR1 ENSG00000263345 DPH1
GH17G001712 1.8 FANTOM5 ENCODE dbSUPER 23.7 +796.1 796132 7.0 MLX CREB3L1 DMAP1 YBX1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 SMYD4 RPA1 SERPINF2 METTL16 TSR1 TLCD2 GEMIN4 SMG6 ENSG00000263345 WDR81
GH17G002207 0.8 dbSUPER 52.4 +303.7 303712 1.9 ZNF493 ZNF138 ZNF354C ZNF202 ZNF680 ZBTB11 ZNF426 ZNF623 ZNF781 ZNF518A METTL16 SMYD4 RPA1 HNRNPA1P16 ENSG00000263345 SMG6 ENSG00000263050 RN7SL608P TSR1 CRK
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around METTL16 on UCSC Golden Path with GeneCards custom track

Promoters for METTL16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for METTL16 Gene

2,405,562 bp from pter
2,511,906 bp from pter
106,345 bases
Minus strand

Genomic View for METTL16 Gene

Genes around METTL16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL16 Gene

Proteins for METTL16 Gene

  • Protein details for METTL16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Methyltransferase-like protein 16
    Protein Accession:
    Secondary Accessions:
    • D3DTI8
    • Q86TE5
    • Q96T16
    • Q9BVG7

    Protein attributes for METTL16 Gene

    562 amino acids
    Molecular mass:
    63621 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB55094.1; Type=Erroneous termination; Positions=505; Note=Translated as Lys.; Evidence={ECO:0000305}; Sequence=CAD89999.2; Type=Frameshift; Positions=424; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for METTL16 Gene

    Alternative splice isoforms for METTL16 Gene


neXtProt entry for METTL16 Gene

Post-translational modifications for METTL16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for METTL16 Gene

No data available for DME Specific Peptides for METTL16 Gene

Domains & Families for METTL16 Gene

Gene Families for METTL16 Gene

Protein Domains for METTL16 Gene

Suggested Antigen Peptide Sequences for METTL16 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the methyltransferase superfamily. METTL16/RlmF family.
  • Belongs to the methyltransferase superfamily. METTL16/RlmF family.
genes like me logo Genes that share domains with METTL16: view

Function for METTL16 Gene

Molecular function for METTL16 Gene

UniProtKB/Swiss-Prot Function:
Probable methyltransferase.

Enzyme Numbers (IUBMB) for METTL16 Gene

Gene Ontology (GO) - Molecular Function for METTL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0052907 23S rRNA (adenine(1618)-N(6))-methyltransferase activity IBA --
genes like me logo Genes that share ontologies with METTL16: view

Phenotypes for METTL16 Gene

genes like me logo Genes that share phenotypes with METTL16: view

Animal Models for METTL16 Gene

MGI Knock Outs for METTL16:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for METTL16 Gene

Localization for METTL16 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL16 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for METTL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with METTL16: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for METTL16 Gene

Pathways & Interactions for METTL16 Gene

SuperPathways for METTL16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for METTL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
GO:0070475 rRNA base methylation IBA --
genes like me logo Genes that share ontologies with METTL16: view

No data available for Pathways by source and SIGNOR curated interactions for METTL16 Gene

Drugs & Compounds for METTL16 Gene

No Compound Related Data Available

Transcripts for METTL16 Gene

Unigene Clusters for METTL16 Gene

Methyltransferase like 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL16 Gene

No ASD Table

Relevant External Links for METTL16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for METTL16 Gene

Protein differential expression in normal tissues from HIPED for METTL16 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.3) and CD8 Tcells (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for METTL16 Gene

Protein tissue co-expression partners for METTL16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of METTL16 Gene:


SOURCE GeneReport for Unigene cluster for METTL16 Gene:


Evidence on tissue expression from TISSUES for METTL16 Gene

  • Nervous system(4.7)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with METTL16: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL16 Gene

Orthologs for METTL16 Gene

This gene was present in the common ancestor of animals.

Orthologs for METTL16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia METTL16 34 35
  • 99.53 (n)
(Canis familiaris)
Mammalia METTL16 34 35
  • 89.88 (n)
(Bos Taurus)
Mammalia METTL16 34 35
  • 89.35 (n)
-- 35
  • 75 (a)
(Mus musculus)
Mammalia Mettl16 34 16 35
  • 86.47 (n)
(Monodelphis domestica)
Mammalia METTL16 35
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia METTL16 35
  • 74 (a)
(Gallus gallus)
Aves METTL16 34 35
  • 71.15 (n)
(Anolis carolinensis)
Reptilia METTL16 35
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl16 34
  • 68.4 (n)
Str.3947 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.7647 34
(Danio rerio)
Actinopterygii mettl16 34 35
  • 71.84 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2774 34
fruit fly
(Drosophila melanogaster)
Insecta CG7544 34 35
  • 51 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011889 34
  • 45 (n)
(Caenorhabditis elegans)
Secernentea mett-10 34 35
  • 48.71 (n)
Species where no ortholog for METTL16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL16 Gene

Gene Tree for METTL16 (if available)
Gene Tree for METTL16 (if available)

Paralogs for METTL16 Gene

No data available for Paralogs for METTL16 Gene

Variants for METTL16 Gene

Sequence variations from dbSNP and Humsavar for METTL16 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000002512 -- 2,449,497(+) GCCAC(C/T)ATGTC intron-variant
rs1000010457 -- 2,452,732(+) CCTTC(A/G)TTCTG intron-variant
rs1000050927 -- 2,492,754(+) TAGCC(A/G)GGTGT intron-variant
rs1000138064 -- 2,449,140(+) AAATA(C/G)ATAAA intron-variant
rs1000152506 -- 2,487,968(+) TCACT(A/G)TATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for METTL16 Gene

Variant ID Type Subtype PubMed ID
esv22012 CNV loss 19812545
esv2669015 CNV deletion 23128226
esv2675053 CNV deletion 23128226
esv3554000 CNV deletion 23714750
esv3639709 CNV loss 21293372
esv3639710 CNV loss 21293372
esv3892947 CNV gain 25118596
nsv1063109 CNV gain 25217958
nsv1066055 CNV gain 25217958
nsv1109041 CNV deletion 24896259
nsv1110917 OTHER inversion 24896259
nsv1113841 CNV deletion 24896259
nsv111844 CNV deletion 16902084
nsv1144785 CNV deletion 24896259
nsv574224 CNV gain 21841781
nsv819217 CNV loss 19587683
nsv833338 CNV loss 17160897

Variation tolerance for METTL16 Gene

Residual Variation Intolerance Score: 28.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.01; 50.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for METTL16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL16 Gene

Disorders for METTL16 Gene

Relevant External Links for METTL16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for METTL16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL16 Gene

Publications for METTL16 Gene

  1. The ybiN gene of Escherichia coli encodes adenine-N6 methyltransferase specific for modification of A1618 of 23 S ribosomal RNA, a methylated residue located close to the ribosomal exit tunnel. (PMID: 18021804) Sergiev P.V. … Dontsova O.A. (J. Mol. Biol. 2008) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for METTL16 Gene

Sources for METTL16 Gene

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