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Aliases for METTL16 Gene

Aliases for METTL16 Gene

  • Methyltransferase Like 16 2 3 5
  • Methyltransferase 10 Domain-Containing Protein 3 4
  • Methyltransferase 10 Domain Containing 2 3
  • METT10D 3 4
  • Putative Methyltransferase METT10D 3
  • EC 2.1.1.- 4

External Ids for METTL16 Gene

Previous HGNC Symbols for METTL16 Gene

  • METT10D

Previous GeneCards Identifiers for METTL16 Gene

  • GC17M002319
  • GC17M002316

Summaries for METTL16 Gene

GeneCards Summary for METTL16 Gene

METTL16 (Methyltransferase Like 16) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and 23S rRNA (adenine(1618)-N(6))-methyltransferase activity.

UniProtKB/Swiss-Prot for METTL16 Gene

  • Probable methyltransferase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL16 Gene

Genomics for METTL16 Gene

Regulatory Elements for METTL16 Gene

Enhancers for METTL16 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around METTL16 on UCSC Golden Path with GeneCards custom track

Promoters for METTL16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around METTL16 on UCSC Golden Path with GeneCards custom track

Genomic Location for METTL16 Gene

2,405,562 bp from pter
2,511,906 bp from pter
106,345 bases
Minus strand

Genomic View for METTL16 Gene

Genes around METTL16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL16 Gene

Proteins for METTL16 Gene

  • Protein details for METTL16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Methyltransferase-like protein 16
    Protein Accession:
    Secondary Accessions:
    • D3DTI8
    • Q86TE5
    • Q96T16
    • Q9BVG7

    Protein attributes for METTL16 Gene

    562 amino acids
    Molecular mass:
    63621 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB55094.1; Type=Erroneous termination; Positions=505; Note=Translated as Lys.; Evidence={ECO:0000305}; Sequence=CAD89999.2; Type=Frameshift; Positions=424; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for METTL16 Gene

    Alternative splice isoforms for METTL16 Gene


neXtProt entry for METTL16 Gene

Proteomics data for METTL16 Gene at MOPED

Post-translational modifications for METTL16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for METTL16 Gene

No data available for DME Specific Peptides for METTL16 Gene

Domains & Families for METTL16 Gene

Gene Families for METTL16 Gene

Protein Domains for METTL16 Gene

Suggested Antigen Peptide Sequences for METTL16 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the methyltransferase superfamily. METTL16/RlmF family.
  • Belongs to the methyltransferase superfamily. METTL16/RlmF family.
genes like me logo Genes that share domains with METTL16: view

Function for METTL16 Gene

Molecular function for METTL16 Gene

UniProtKB/Swiss-Prot Function:
Probable methyltransferase.

Enzyme Numbers (IUBMB) for METTL16 Gene

Gene Ontology (GO) - Molecular Function for METTL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0052907 23S rRNA (adenine(1618)-N(6))-methyltransferase activity IBA --
genes like me logo Genes that share ontologies with METTL16: view

Phenotypes for METTL16 Gene

genes like me logo Genes that share phenotypes with METTL16: view

Animal Models for METTL16 Gene

MGI Knock Outs for METTL16:

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for METTL16 Gene

Localization for METTL16 Gene

Subcellular locations from

Jensen Localization Image for METTL16 Gene COMPARTMENTS Subcellular localization image for METTL16 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for METTL16 Gene

Pathways & Interactions for METTL16 Gene

SuperPathways for METTL16 Gene

No Data Available

Interacting Proteins for METTL16 Gene

Gene Ontology (GO) - Biological Process for METTL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL16: view

No data available for Pathways by source and SIGNOR curated interactions for METTL16 Gene

Drugs & Compounds for METTL16 Gene

No Compound Related Data Available

Transcripts for METTL16 Gene

Unigene Clusters for METTL16 Gene

Methyltransferase like 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for METTL16 Gene

No ASD Table

Relevant External Links for METTL16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL16 Gene

mRNA expression in normal human tissues for METTL16 Gene

Protein differential expression in normal tissues from HIPED for METTL16 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.3) and CD8 Tcells (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for METTL16 Gene

SOURCE GeneReport for Unigene cluster for METTL16 Gene Hs.632237

genes like me logo Genes that share expression patterns with METTL16: view

Protein tissue co-expression partners for METTL16 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for METTL16 Gene

Orthologs for METTL16 Gene

This gene was present in the common ancestor of animals.

Orthologs for METTL16 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia METTL16 35
  • 89.35 (n)
  • 91.25 (a)
-- 36
  • 75 (a)
METTL16 36
  • 91 (a)
(Canis familiaris)
Mammalia METTL16 35
  • 89.88 (n)
  • 92.86 (a)
METTL16 36
  • 93 (a)
(Mus musculus)
Mammalia Mettl16 35
  • 86.47 (n)
  • 89.49 (a)
Mettl16 16
Mettl16 36
  • 89 (a)
(Pan troglodytes)
Mammalia METTL16 35
  • 99.53 (n)
  • 99.82 (a)
METTL16 36
  • 100 (a)
(Monodelphis domestica)
Mammalia METTL16 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia METTL16 36
  • 74 (a)
(Gallus gallus)
Aves METTL16 35
  • 71.15 (n)
  • 77.02 (a)
METTL16 36
  • 77 (a)
(Anolis carolinensis)
Reptilia METTL16 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl16 35
  • 68.4 (n)
  • 75.42 (a)
Str.3947 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7647 35
(Danio rerio)
Actinopterygii mettl16 35
  • 71.84 (n)
  • 80.37 (a)
mettl16 36
  • 75 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2774 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011889 35
  • 45 (n)
  • 39.26 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7544 35
  • 51 (n)
  • 45.23 (a)
CG7544 36
  • 44 (a)
(Caenorhabditis elegans)
Secernentea mett-10 35
  • 48.71 (n)
  • 42.26 (a)
mett-10 36
  • 33 (a)
Species with no ortholog for METTL16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL16 Gene

Gene Tree for METTL16 (if available)
Gene Tree for METTL16 (if available)

Paralogs for METTL16 Gene

No data available for Paralogs for METTL16 Gene

Variants for METTL16 Gene

Sequence variations from dbSNP and Humsavar for METTL16 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs17834783 - 2,420,223(+) GACAA(A/C/T)TTTCC reference, missense
rs935134 -- 2,511,255(-) AAGGA(A/G)ACAGA intron-variant
rs1056321 -- 2,419,482(-) CCCAC(A/G)AAGGG utr-variant-3-prime
rs1867198 -- 2,490,147(+) GACTC(C/G)ATATG intron-variant
rs1545272 -- 2,490,653(+) AAAAC(A/G)GGTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for METTL16 Gene

Variant ID Type Subtype PubMed ID
nsv907532 CNV Loss 21882294
nsv833338 CNV Loss 17160897
nsv819217 CNV Loss 19587683
nsv111844 CNV Loss 16902084
nsv907538 CNV Loss 21882294
nsv907539 CNV Gain 21882294
esv2675053 CNV Deletion 23128226
esv2669015 CNV Deletion 23128226
esv22012 CNV Loss 19812545

Variation tolerance for METTL16 Gene

Residual Variation Intolerance Score: 28.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.01; 50.03% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for METTL16 Gene

Disorders for METTL16 Gene

Relevant External Links for METTL16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for METTL16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL16 Gene

Publications for METTL16 Gene

  1. The ybiN gene of Escherichia coli encodes adenine-N6 methyltransferase specific for modification of A1618 of 23 S ribosomal RNA, a methylated residue located close to the ribosomal exit tunnel. (PMID: 18021804) Sergiev P.V. … Dontsova O.A. (J. Mol. Biol. 2008) 2 3 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for METTL16 Gene

Sources for METTL16 Gene