Aliases for METTL16 Gene
Aliases for METTL16 Gene
External Ids for METTL16 Gene
- HGNC: 28484
- Entrez Gene: 79066
- Ensembl: ENSG00000127804
- UniProtKB: Q86W50
Previous HGNC Symbols for METTL16 Gene
- METT10D
Previous GeneCards Identifiers for METTL16 Gene
- GC17M002319
- GC17M002316
Summaries for METTL16 Gene
GeneCards Summary for METTL16 Gene
METTL16 (Methyltransferase Like 16) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and 23S rRNA (adenine(1618)-N(6))-methyltransferase activity.
UniProtKB/Swiss-Prot for METTL16 Gene
-
Probable methyltransferase.
No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL16 Gene
Genomics for METTL16 Gene
Regulatory Elements for METTL16 Gene
Enhancers for METTL16 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around METTL16 on UCSC Golden Path with GeneCards custom track
Promoters for METTL16 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around METTL16 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for METTL16 Gene
- Chromosome:
- 17
- Start:
- 2,405,562 bp from pter
- End:
- 2,511,906 bp from pter
- Size:
- 106,345 bases
- Orientation:
- Minus strand
Genomic View for METTL16 Gene
Genes around METTL16 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p13.3 by Ensembl
- 17p13.3 by Entrez Gene
- 17p13.3 by HGNC
METTL16 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for METTL16 Gene
Proteins for METTL16 Gene
-
Protein details for METTL16 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86W50-MET16_HUMAN
- Recommended name:
- Methyltransferase-like protein 16
- Protein Accession:
- Q86W50
- D3DTI8
- Q86TE5
- Q96T16
- Q9BVG7
Protein attributes for METTL16 Gene
- Size:
- 562 amino acids
- Molecular mass:
- 63621 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAB55094.1; Type=Erroneous termination; Positions=505; Note=Translated as Lys.; Evidence={ECO:0000305}; Sequence=CAD89999.2; Type=Frameshift; Positions=424; Evidence={ECO:0000305};
Protein Expression for METTL16 Gene
Post-translational modifications for METTL16 Gene
Other Protein References for METTL16 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for METTL16
- Invitrogen Antibodies for METTL16
- antibodies-online Antibodies for METTL16: See all 34
- Search GeneTex for Antibodies for METTL16
-
Santa Cruz Biotechnology (SCBT) Antibodies for METTL16
Protein Products
-
OriGene Purified Proteins for METTL16
- Search Origene for MassSpec and Protein Over-expression Lysates for METTL16
- Origene Custom Protein Services for METTL16
- antibodies-online Proteins for METTL16: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for METTL16
Assay Products
No data available for DME Specific Peptides for METTL16 Gene
Domains & Families for METTL16 Gene
Gene Families for METTL16 Gene
Protein Domains for METTL16 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for METTL16 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q86W50UniProtKB/Swiss-Prot:
MET16_HUMAN :- Belongs to the methyltransferase superfamily. METTL16/RlmF family.
- Family:
-
- Belongs to the methyltransferase superfamily. METTL16/RlmF family.
Function for METTL16 Gene
Molecular function for METTL16 Gene
- UniProtKB/Swiss-Prot Function:
- Probable methyltransferase.
Enzyme Numbers (IUBMB) for METTL16 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0052907 | 23S rRNA (adenine(1618)-N(6))-methyltransferase activity | IBA | -- |
Phenotypes for METTL16 Gene
- MGI mutant phenotypes for METTL16:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for METTL16:
Animal Models for METTL16 Gene
- MGI Knock Outs for METTL16:
-
- Mettl16 tm1b(KOMP)Mbp
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for METTL16 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for METTL16 gene
- Search ViGene Biosciences for METTL16
CRISPR Products
-
OriGene CRISPR knockouts for METTL16
-
Santa Cruz Biotechnology (SCBT) CRISPR for METTL16
- GenScript: Design CRISPR guide RNA sequences for METTL16
miRNA for METTL16 Gene
- miRTarBase miRNAs that target METTL16
-
- hsa-mir-26b-5p (MIRT029350)
- hsa-mir-193b-3p (MIRT041591)
- hsa-mir-423-3p (MIRT042576)
- hsa-mir-92a-3p (MIRT049235)
- hsa-mir-1178-3p (MIRT614545)
- hsa-mir-3941 (MIRT614546)
- hsa-mir-4643 (MIRT614547)
- hsa-mir-603 (MIRT614548)
- hsa-mir-362-3p (MIRT614549)
- hsa-mir-329-3p (MIRT614550)
- hsa-mir-8485 (MIRT614551)
- hsa-mir-587 (MIRT664733)
- hsa-mir-3692-3p (MIRT664734)
- hsa-mir-3156-3p (MIRT664735)
- hsa-mir-1260b (MIRT664736)
- hsa-mir-1260a (MIRT664737)
- hsa-mir-188-3p (MIRT664738)
- hsa-mir-6509-3p (MIRT664739)
- hsa-mir-4436b-5p (MIRT664740)
- hsa-mir-3119 (MIRT664741)
- hsa-mir-876-5p (MIRT664742)
- hsa-mir-3167 (MIRT664743)
- hsa-mir-627-3p (MIRT664744)
- hsa-mir-6777-3p (MIRT664745)
miRNA Products
- Search ViGene Biosciences for METTL16
Inhibitory RNA Products
- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for METTL16
- Browse OriGene Inhibitory RNA Products For METTL16
-
ViGene Biosciences ready-to-package AAV shRNAs for METTL16 gene
Clone Products
- OriGene clones in human for METTL16
- OriGene ORF clones in human,mouse for METTL16
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for METTL16 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for METTL16 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for METTL16 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for METTL16 Gene
Localization for METTL16 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for METTL16 Gene
Pathways & Interactions for METTL16 Gene
More details on SuperPathways for METTL16
No Data Available
Interacting Proteins for METTL16 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0032259 | methylation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for METTL16 Gene
Transcripts for METTL16 Gene
mRNA/cDNA for METTL16 Gene
- (3) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (198) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for METTL16 Gene
CRISPR Products
-
OriGene CRISPR knockouts for METTL16
-
Santa Cruz Biotechnology (SCBT) CRISPR for METTL16
- GenScript: Design CRISPR guide RNA sequences for METTL16
miRNA Products
- Search ViGene Biosciences for METTL16
Inhibitory RNA Products
- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for METTL16
- Browse OriGene Inhibitory RNA Products For METTL16
-
ViGene Biosciences ready-to-package AAV shRNAs for METTL16 gene
Clone Products
- OriGene clones in human for METTL16
- OriGene ORF clones in human,mouse for METTL16
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for METTL16 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (24.3) and CD8 Tcells (7.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for METTL16 Gene
SOURCE GeneReport for Unigene cluster for METTL16 Gene Hs.632237
- Elite partner
Primer Products
-
OriGene qPCR primer pairs for METTL16
-
OriGene qPCR primer pairs and template standards for METTL16
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for METTL16 Gene
Orthologs for METTL16 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | METTL16 35 |
|
||
| -- 36 |
|
OneToMany | |||
| METTL16 36 |
|
OneToMany | |||
| dog (Canis familiaris) |
Mammalia | METTL16 35 |
|
||
| METTL16 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Mettl16 35 |
|
||
| Mettl16 16 |
|
||||
| Mettl16 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | METTL16 35 |
|
||
| METTL16 36 |
|
OneToOne | |||
| oppossum (Monodelphis domestica) |
Mammalia | METTL16 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | METTL16 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | METTL16 35 |
|
||
| METTL16 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | METTL16 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mettl16 35 |
|
||
| Str.3947 35 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.7647 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mettl16 35 |
|
||
| mettl16 36 |
|
OneToOne | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2774 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011889 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG7544 35 |
|
||
| CG7544 36 |
|
OneToOne | |||
| worm (Caenorhabditis elegans) |
Secernentea | mett-10 35 |
|
||
| mett-10 36 |
|
OneToOne |
- Species with no ortholog for METTL16:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for METTL16 Gene
No data available for Paralogs for METTL16 Gene
Variants for METTL16 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs17834783 | - | 2,420,223(+) | GACAA(A/C/T)TTTCC | reference, missense | |
| rs935134 | -- | 2,511,255(-) | AAGGA(A/G)ACAGA | intron-variant | |
| rs1056321 | -- | 2,419,482(-) | CCCAC(A/G)AAGGG | utr-variant-3-prime | |
| rs1867198 | -- | 2,490,147(+) | GACTC(C/G)ATATG | intron-variant | |
| rs1545272 | -- | 2,490,653(+) | AAAAC(A/G)GGTCC | intron-variant |
Residual Variation Intolerance Score:
28.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.01;
50.03% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for METTL16 Gene
Disorders for METTL16 Gene
Relevant External Links for METTL16
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- METTL16
No disorders were found for METTL16 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL16 Gene
Publications for METTL16 Gene
- The ybiN gene of Escherichia coli encodes adenine-N6 methyltransferase specific for modification of A1618 of 23 S ribosomal RNA, a methylated residue located close to the ribosomal exit tunnel. (PMID: 18021804) Sergiev P.V. … Dontsova O.A. (J. Mol. Biol. 2008) 2 3 67
- Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
- Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
- Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
Products for METTL16 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse Cell Culture Products
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- Browse Proteome Profiler Antibody Arrays
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- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for METTL16
- Search Origene for MassSpec and Protein Over-expression Lysates for METTL16
- Origene Custom Protein Services for METTL16
- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for METTL16
- Browse OriGene Inhibitory RNA Products For METTL16
- OriGene qPCR primer pairs for METTL16
- OriGene qPCR primer pairs and template standards for METTL16
- OriGene CRISPR knockouts for METTL16
- OriGene clones in human for METTL16
- OriGene ORF clones in human,mouse for METTL16
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for METTL16
- GenScript Custom Assay Services for METTL16
- GenScript Custom overexpressing Cell Line Services for METTL16
- GenScript: Design CRISPR guide RNA sequences for METTL16
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for METTL16
- Novus Biologicals Antibodies for METTL16
- Novus Biologicals proteins and lysates for METTL16
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for METTL16: See all 34
- Search antibodies-online for kits
- antibodies-online Proteins for METTL16: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for METTL16
- Search GeneTex for Proteins for METTL16
- ViGene Biosciences adenoviral particle packaged cDNA for METTL16 gene
- ViGene Biosciences lentiviral particle packaged cDNA for METTL16 gene
- ViGene Biosciences lentiviral particle packaged cDNA for METTL16 gene
- ViGene Biosciences ready-to-package AAV shRNAs for METTL16 gene
- ViGene Biosciences ready-to-package AAV shRNAs for METTL16 gene
- ViGene Biosciences ready-to-package AAV shRNAs for METTL16 gene
- Search ViGene Biosciences for METTL16
- Search ViGene Biosciences for METTL16
- Santa Cruz Biotechnology (SCBT) Antibodies for METTL16
- Search Santa Cruz Biotechnology (SCBT) for METTL16 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for METTL16
Sources for METTL16 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon