METTL16 Gene
protein-coding GIFtS: 41
GCID: GC17M002319
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Methyltransferase Like 16(Previous name: methyltransferase 10 domain containing)
(Previous symbol: METT10D)
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Aliases
for METTL16 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
About This Section
|
| Aliases |
|---|
| Methyltransferase Like 161 2 | | Methyltransferase-Like Protein 162 | | METT10D1 2 3 | | Putative Methyltransferase METT10D2 | | Methyltransferase 10 Domain Containing1 2 | | EC 2.1.1.-3 | | Methyltransferase 10 Domain-Containing Protein2 3 | | |
Export aliases for METTL16 gene to outside databases |
Summaries
for METTL16 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
GeneCards Summary for METTL16 Gene: 
METTL16 (methyltransferase like 16) is a protein-coding gene. GO annotations related to this gene include methyltransferase activity.
UniProtKB/Swiss-Prot: MET16_HUMAN, Q86W50Function: Probable methyltransferase (By similarity)
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Genomic Views
for METTL16 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 73),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NT_010718.16 NC_018928.2
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for METTL16
Other transcription factors
Search SABiosciences Chromatin IP Primers for METTL16
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL16 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.3 Ensembl cytogenetic band: 17p13.3 HGNC cytogenetic band: 17p13.3METTL16 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M002319: view genomic region
(about GC identifiers)
Start:
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2,319,343 bp from pter |
End:
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2,415,200 bp from pter |
Size:
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95,858 bases |
Orientation:
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minus strand |
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Proteins
for METTL16 gene
(According to
UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MAXQB
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
About This Section
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UniProtKB/Swiss-Prot: MET16_HUMAN, Q86W50 (See
protein sequence)Recommended Name: Methyltransferase-like protein 16 Size: 562 amino acids; 63621 Da
Sequence caution: Sequence=BAB55094.1; Type=Erroneous termination; Positions=505; Note=Translated as Lys;
Sequence=CAD89999.2; Type=Frameshift; Positions=424;
1 PDB 3D structure from  and Proteopedia  for METTL16:2H00 (3D)
Secondary accessions: D3DTI8 Q86TE5 Q96T16 Q9BVG7Alternative splicing: 2 isoforms: Q86W50-1 Q86W50-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for METTL16: NX_Q86W50
Explore proteomics data for METTL16 at MOPED
Post-translational modifications:
View modification sites using PhosphoSitePlusView neXtProt modification sites for NX_Q86W50
METTL16 Protein expression data from MOPED1, PaxDb2 and
MAXQB3 : About this image 
REFSEQ proteins: NP_076991.3
ENSEMBL proteins: ENSP00000458710 ENSP00000263092 ENSP00000460775 ENSP00000460207 ENSP00000465733 ENSP00000461546 ENSP00000443633
Human Recombinant Protein Products for METTL16:
METTL16 Antibody Products:
Assay Products for METTL16: |
Protein
Domains /
Families
for METTL16 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| 2 InterPro protein domains:Graphical View of Domain Structure for InterPro Entry Q86W50 ProtoNet protein and cluster: Q86W50 UniProtKB/Swiss-Prot: MET16_HUMAN, Q86W50Similarity: Belongs to the methyltransferase superfamily. METTL16/RlmF family
METTL16 for domains About GeneDecksing
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Function
for METTL16 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
Vector BioLabs,
and Sirion Biotech,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene.)
About This Section
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Molecular Function:
UniProtKB/Swiss-Prot Summary: MET16_HUMAN, Q86W50Function: Probable methyltransferase (By similarity) Enzyme Number (IUBMB): EC 2.1.1.-1
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0008168 | methyltransferase activity |
IEA | -- |
METTL16 for ontologies About GeneDecksing
Animal Models:
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for METTL16 | |  | Search LifeMap BioReagents cell lines for METTL16 | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL16 |
Pathways & Interactions
for METTL16 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for METTL16
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for METTL16 (Q86W503 ENSP000002630924) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for METTL16 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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 Browse Tocris compounds for METTL16 (MET16)
Search CenterWatch for drugs/clinical trials and news about METTL16 / MET16
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Transcripts
for METTL16 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Sirion Biotech,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for METTL16 gene: NM_024086.3 Unigene Cluster for METTL16: Methyltransferase like 16 Hs.632237 [show with all ESTs]Unigene Representative Sequence: NM_02408610 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000574623 ENST00000576155(uc002fut.3 uc002fuu.4 uc002fuv.3)
ENST00000571669(uc010cka.3) ENST00000263092(uc010vqx.1 uc010vqy.1)
ENST00000576556 ENST00000574752 ENST00000571298 ENST00000576976 ENST00000577148
ENST00000538844
Primer
Products: |  | OriGene qPCR primer pairs and template standards for METTL16
OriGene qSTAR qPCR primer pairs in human, mouse for METTL16
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat METTL16 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL16 |
Additional mRNA sequence: AK027410.1 AK098286.1 AK294547.1 AK296464.1 AL832612.2 BC001213.1 BC047770.1 BC050603.1 BX647255.1 14 DOTS entries: DT.100784401 DT.315243 DT.95250220 DT.101982043 DT.120948776 DT.120948777 DT.100023147 DT.99948339 DT.91697169 DT.91711600 DT.100035865 DT.120948768 DT.92419553 DT.120948699 24/198 AceView cDNA sequences (see all 198): BC050603 AI684986 AA931537 BX281910 AW303538 BM981103 BM838546 F00469 BU195372 BM669313 BX281827 Z39510 BE348790 AI791528 AI298404 AI733038 BF924710 BM456665 D31132 AA505863 AA527563 BX105079 CB215532 F04092
GeneLoc Exon Structure
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Expression
for METTL16 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| METTL16 expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
About this image
See METTL16 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for METTL16
SOURCE GeneReport for Unigene cluster: Hs.632237
SABiosciences Custom PCR Arrays for METTL16
Primer
Products: | | OriGene qPCR primer pairs and template standards for METTL16
OriGene qSTAR qPCR primer pairs in human, mouse for METTL16
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat METTL16 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL16 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL16 |
Orthologs
for METTL16 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for METTL16 gene from 7/15 species (see all 15) About this table
ENSEMBL Gene Tree for METTL16 (if available)
TreeFam Gene Tree for METTL16 (if available) |
Paralogs
for METTL16 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for METTL16 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for METTL16 (2319343 - 2415200 bp)
Structural Variations
Database of Genomic Variants (DGV) 9 variations for METTL16: About this table
| | SABiosciences Cancer Mutation PCR Assays |
| | SeqTarget long-range PCR primers for resequencing METTL16 |
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Disorders
/ Diseases
for METTL16 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for METTL16 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for METTL16 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with METTL16) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The ybiN gene of Escherichia coli encodes adenine-N6 methyltransferase specific for modification of A1618 of 23 S ribosomal RNA, a methylated residue located close to the ribosomal exit tunnel. (PubMed id 18021804)1, 3 Sergiev P.V....Dontsova O.A. (2008)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Generalist genes analysis of DNA markers associated w ith mathematical ability and disability reveals shared influence across ages an d abilities. (PubMed id 20602751)1 Docherty S.J....Plomin R. (2010)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PubMed id 17643375)1 Jeronimo C.... Coulombe B. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
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External Searches for METTL16 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing METTL16 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing METTL16 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing METTL16 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for METTL16 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for METTL16 gene:
Search GeneIP for patents involving METTL16
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for METTL16 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat METTL16 | | | QIAGEN SeqTarget long-range PCR primers for resequencing METTL16 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL16 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat METTL16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL16 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL16 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL16 |
|  |  |  |  | | | | ThermoFisher Antibodies for METTL16 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL16 |
| |  |  |  | | | | LSBio Antibodies in human, mouse, rat for METTL16 |
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Last full update: 23 Oct 2013 -
Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014
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