Aliases for METTL16 Gene
External Ids for METTL16 Gene
Previous HGNC Symbols for METTL16 Gene
Previous GeneCards Identifiers for METTL16 Gene
GeneCards Summary for METTL16 Gene
METTL16 (Methyltransferase Like 16) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and 23S rRNA (adenine(1618)-N(6))-methyltransferase activity.
UniProtKB/Swiss-Prot for METTL16 Gene
RNA N6-methyltransferase that methylates adenosine residues of a subset of RNAs and plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:28525753). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5UACAGAGAA-3 nonamer sequence and a specific RNA structure (PubMed:28525753). In presence of S-adenosyl-L-methionine, binds the 3-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, leading to intron retention and preventing MAT2A mRNA splicing (PubMed:28525753). In S-adenosyl-L-methionine-limiting conditions, binds the 3-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, leading to stimulate splicing of the MAT2A retained intron, and promoting expression of MAT2A (PubMed:28525753). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (PubMed:28525753). Specifically binds the 3-end of the MALAT1 long non-coding RNA (PubMed:27872311).