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Aliases for METTL15 Gene

Aliases for METTL15 Gene

  • Methyltransferase Like 15 2 3
  • Methyltransferase 5 Domain-Containing Protein 1 3 4
  • Methyltransferase 5 Domain Containing 1 2 3
  • METT5D1 3 4
  • Probable S-Adenosyl-L-Methionine-Dependent Methyltransferase METT5D1 3
  • Putative S-Adenosyl-L-Methionine-Dependent Methyltransferase METT5D1 3
  • EC 2.1.1.- 4

External Ids for METTL15 Gene

Previous HGNC Symbols for METTL15 Gene

  • METT5D1

Summaries for METTL15 Gene

GeneCards Summary for METTL15 Gene

METTL15 (Methyltransferase Like 15) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity and rRNA (cytosine-N4-)-methyltransferase activity.

UniProtKB/Swiss-Prot for METTL15 Gene

  • Probable S-adenosyl-L-methionine-dependent methyltransferase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL15 Gene

Genomics for METTL15 Gene

Genomic Location for METTL15 Gene

28,108,248 bp from pter
28,527,041 bp from pter
418,794 bases
Plus strand

Genomic View for METTL15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for METTL15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL15 Gene

No data available for Regulatory Elements for METTL15 Gene

Proteins for METTL15 Gene

  • Protein details for METTL15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable methyltransferase-like protein 15
    Protein Accession:
    Secondary Accessions:
    • A8MRS5
    • B7WNU2
    • Q3MHD3
    • Q8N601
    • Q8NBA7

    Protein attributes for METTL15 Gene

    407 amino acids
    Molecular mass:
    46121 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH30997.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for METTL15 Gene


neXtProt entry for METTL15 Gene

Proteomics data for METTL15 Gene at MOPED

Post-translational modifications for METTL15 Gene

  • Ubiquitination at Lys 352 and Lys 381
  • Modification sites at PhosphoSitePlus

Other Protein References for METTL15 Gene

No data available for DME Specific Peptides for METTL15 Gene

Domains & Families for METTL15 Gene

Gene Families for METTL15 Gene

Protein Domains for METTL15 Gene

Suggested Antigen Peptide Sequences for METTL15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the methyltransferase superfamily. RsmH family.
  • Belongs to the methyltransferase superfamily. RsmH family.
genes like me logo Genes that share domains with METTL15: view

Function for METTL15 Gene

Molecular function for METTL15 Gene

UniProtKB/Swiss-Prot Function:
Probable S-adenosyl-L-methionine-dependent methyltransferase.

Enzyme Numbers (IUBMB) for METTL15 Gene

Gene Ontology (GO) - Molecular Function for METTL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008168 methyltransferase activity --
GO:0071424 rRNA (cytosine-N4-)-methyltransferase activity IBA --
genes like me logo Genes that share ontologies with METTL15: view

Phenotypes for METTL15 Gene

GenomeRNAi human phenotypes for METTL15:
genes like me logo Genes that share phenotypes with METTL15: view

Animal Model Products

CRISPR Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for METTL15 Gene

Localization for METTL15 Gene

Subcellular locations from

Jensen Localization Image for METTL15 Gene COMPARTMENTS Subcellular localization image for METTL15 gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 2
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for METTL15 Gene

Pathways & Interactions for METTL15 Gene

SuperPathways for METTL15 Gene

No Data Available

Interacting Proteins for METTL15 Gene

Gene Ontology (GO) - Biological Process for METTL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070475 rRNA base methylation IBA --
genes like me logo Genes that share ontologies with METTL15: view

No data available for Pathways by source and SIGNOR curated interactions for METTL15 Gene

Drugs & Compounds for METTL15 Gene

(1) Drugs for METTL15 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
genes like me logo Genes that share compounds with METTL15: view

Transcripts for METTL15 Gene

Unigene Clusters for METTL15 Gene

Methyltransferase like 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for METTL15

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL15 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - - - - -
SP2: - - -
SP3: - - - -

Relevant External Links for METTL15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL15 Gene

mRNA expression in normal human tissues for METTL15 Gene

Protein differential expression in normal tissues from HIPED for METTL15 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (39.7), Cervix (14.2), and Plasma (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for METTL15 Gene

SOURCE GeneReport for Unigene cluster for METTL15 Gene Hs.243326

genes like me logo Genes that share expression patterns with METTL15: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for METTL15 Gene

Orthologs for METTL15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METTL15 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia METTL15 35
  • 88.62 (n)
  • 86.24 (a)
METTL15 36
  • 86 (a)
(Canis familiaris)
Mammalia METTL15 35
  • 88.7 (n)
  • 86.24 (a)
METTL15 36
  • 86 (a)
(Mus musculus)
Mammalia Mettl15 35
  • 80.79 (n)
  • 78.82 (a)
Mettl15 16
Mettl15 36
  • 79 (a)
(Pan troglodytes)
Mammalia METTL15 35
  • 99.59 (n)
  • 99.02 (a)
METTL15 36
  • 99 (a)
(Monodelphis domestica)
Mammalia METTL15 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia METTL15 36
  • 70 (a)
(Gallus gallus)
Aves METTL15 35
  • 70.77 (n)
  • 67.84 (a)
METTL15 36
  • 61 (a)
(Anolis carolinensis)
Reptilia METTL15 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl15 35
  • 68.18 (n)
  • 68.58 (a)
Str.17107 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.3963 35
(Danio rerio)
Actinopterygii LOC560573 35
  • 60.5 (n)
  • 58.81 (a)
METTL15 36
  • 50 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8699 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002831 35
  • 50.95 (n)
  • 49.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14683 35
  • 51.38 (n)
  • 47.08 (a)
CG14683 36
  • 44 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G10910 35
  • 47.04 (n)
  • 37.75 (a)
(Oryza sativa)
Liliopsida Os02g0137600 35
  • 45.99 (n)
  • 35.44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
Species with no ortholog for METTL15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for METTL15 Gene

Gene Tree for METTL15 (if available)
Gene Tree for METTL15 (if available)

Paralogs for METTL15 Gene

(1) SIMAP similar genes for METTL15 Gene using alignment to 3 proteins: Pseudogenes for METTL15 Gene

genes like me logo Genes that share paralogs with METTL15: view

No data available for Paralogs for METTL15 Gene

Variants for METTL15 Gene

Sequence variations from dbSNP and Humsavar for METTL15 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs868607 -- 28,472,959(-) AACAG(A/T)CCTAG intron-variant
rs871004 -- 28,490,911(-) GTTTC(C/T)AATCC intron-variant
rs873756 -- 28,458,863(-) CCAAT(C/G/T)GACAT intron-variant
rs894567 -- 28,491,183(+) ACCCT(A/G)TAATT intron-variant
rs955415 -- 28,357,050(+) CCTGG(C/G)TCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for METTL15 Gene

Variant ID Type Subtype PubMed ID
nsv832096 CNV Loss 17160897
nsv897150 CNV Loss 21882294
dgv1057n71 CNV Loss 21882294
nsv38603 CNV Loss 16902084
esv2670715 CNV Deletion 23128226

Variation tolerance for METTL15 Gene

Residual Variation Intolerance Score: 63.61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.44; 54.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for METTL15 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL15 Gene

Disorders for METTL15 Gene

Relevant External Links for METTL15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with METTL15: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL15 Gene

Publications for METTL15 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation. (PMID: 25582440) Hong J.H. … Raught B. (Mol. Cell Proteomics 2015) 67
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 67

Products for METTL15 Gene

Sources for METTL15 Gene

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