METTL15 Gene
protein-coding GIFtS: 44
GCID: GC11P028129
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|
methyltransferase like 15(Previous name: methyltransferase 5 domain containing 1 )
(Previous symbol: METT5D1)
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Aliases
for METTL15 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Methyltransferase Like 151 2 | | Probable Methyltransferase-Like Protein 152 | | METT5D11 2 3 | | Probable S-Adenosyl-L-Methionine-Dependent Methyltransferase METT5D12 | | Methyltransferase 5 Domain Containing 11 2 | | Putative S-Adenosyl-L-Methionine-Dependent Methyltransferase METT5D12 | | Methyltransferase 5 Domain-Containing Protein 12 3 | | EC 2.1.1.-3 | | FLJ339791 | | |
Export aliases for METTL15 gene to outside databases |
Summaries
for METTL15 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MET15_HUMAN, A6NJ78Function: Probable S-adenosyl-L-methionine-dependent methyltransferase (By similarity)
|
Genomic Views
for METTL15 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for METTL15
Other transcription factors
Search SABiosciences Chromatin IP Primers for METTL15
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL15 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p14.1 Ensembl cytogenetic band: 11p14.1 HGNC cytogenetic band: 11p14.1METTL15 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P028129: view genomic region
(about GC identifiers)
Start:
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28,129,795 bp from pter |
End:
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28,355,054 bp from pter |
Size:
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225,260 bases |
Orientation:
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plus strand |
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Proteins
for METTL15 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MET15_HUMAN, A6NJ78 (See
protein sequence)Recommended Name: Probable methyltransferase-like protein 15 Size: 407 amino acids; 46121 Da
Sequence caution: Sequence=AAH30997.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8MRS5 B7WNU2 Q3MHD3 Q8N601 Q8NBA7Alternative splicing: 4 isoforms: A6NJ78-1 A6NJ78-2 A6NJ78-3 A6NJ78-4 Explore the universe of human proteins at neXtProt for METTL15: NX_A6NJ78
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A6NJ78
METTL15 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001107000.1 NP_689849.2
ENSEMBL proteins: ENSP00000385507 ENSP00000385860 ENSP00000396550 ENSP00000384369 ENSP00000307251 ENSP00000392806 ENSP00000342259 ENSP00000368497
Human Recombinant Protein Products for METTL15:
METTL15 Antibody Products:
Assay Products for METTL15: |
Protein
Domains /
Families
for METTL15 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
METTL15 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A6NJ78ProtoNet protein and cluster: A6NJ78 UniProtKB/Swiss-Prot: MET15_HUMAN, A6NJ78Similarity: Belongs to the methyltransferase superfamily. RsmH family |
Function
for METTL15 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: MET15_HUMAN, A6NJ78Function: Probable S-adenosyl-L-methionine-dependent methyltransferase (By similarity) Enzyme Number (IUBMB): EC 2.1.1.-1
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008168 | methyltransferase activity |
IEA | -- |
METTL15 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL15 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL15 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): METTL15 (NM_001113528) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for METTL15 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL15 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL15 |
|
Pathways & Interactions
for METTL15 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for METTL15
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for METTL15 (A6NJ783 ENSP000003843694) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for METTL15 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for METTL15
Search CenterWatch for drugs/clinical trials and news about METTL15 / MET15
|
Transcripts
for METTL15 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for METTL15 gene (2 alternative transcripts): NM_001113528.1 NM_152636.2 Unigene Cluster for METTL15: Methyltransferase like 15 Hs.243326 [show with all ESTs]Unigene Representative Sequence: NM_1526369 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000406787(uc001mse.2) ENST00000403099 ENST00000451385 ENST00000407364
ENST00000303459 ENST00000437814(uc001msf.1) ENST00000468295 ENST00000342303(uc001msg.2 uc001msh.2)
ENST00000379199
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL15 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL15 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): METTL15 (NM_001113528) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for METTL15 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL15 |
Additional cDNA sequence: AK091261.1 AK091298.1 AL832668.1 BC030997.1 BC066900.1 BC105287.1 10 DOTS entries: DT.100021392 DT.40308369 DT.309227 DT.100745155 DT.402985 DT.430789 DT.99993289 DT.99971248 DT.120841679 DT.97777549 24/66 AceView cDNA sequences (see all 66): AI004348 BM550252 AI433420 AA398002 BM477529 AL558515 AW615337 AL713720 CR601005 AI569925 AA778108 CB107014 AI637581 AI687680 AI702097 BU615240 BU615554 CD654215 AI332808 BI035258 BF963846 BU684235 AK091261 BE892490
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for METTL15 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b |
|---|
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| SP1: | | | | | | | | | - | | - | | - | | | | | | - | | | | - | | | | | | |
| SP2: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | | | | | | | | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for METTL15
|
Expression
for METTL15 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| METTL15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGGTTGGAA
About this image
See METTL15 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for METTL15
SOURCE GeneReport for Unigene cluster: Hs.243326
SABiosciences Custom PCR Arrays for METTL15
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for METTL15
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat METTL15 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL15 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL15 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL15 |
Orthologs
for METTL15 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for METTL15 gene from 9/31 species (see all 31) About this table
ENSEMBL Gene Tree for METTL15 (if available)
TreeFam Gene Tree for METTL15 (if available) |
Paralogs
for METTL15 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for METTL15 gene
1 SIMAP similar gene for METTL15 using alignment to 3 protein entries: MET15_HUMAN (see all proteins):METTL15P1
METTL15 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for METTL15
PGOHUM00000239484 PGOHUM00000250267 PGOHUM00000241663
|
Genomic Variants
for METTL15 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for METTL15 (28129795 - 28355054 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for METTL15: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing METTL15 |
|
Disorders
/ Diseases
for METTL15 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
METTL15 for disorders About GeneDecksing
4  diseases for METTL15: About MalaCardspneumonia tuberculosis malaria mycobacterium tuberculosis
Export disorders for METTL15 gene to outside databases
|
Publications
for METTL15 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for METTL15 gene integrated from 9 sources:
(articles sorted by number of sources associating them with METTL15) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
|
External Searches for METTL15 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing METTL15 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing METTL15 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing METTL15 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for METTL15 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for METTL15 gene:
Search GeneIP for patents involving METTL15
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for METTL15 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for METTL15 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for METTL15 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for METTL15 | | | OriGene Protein Over-expression Lysate for METTL15 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for METTL15 | | OriGene 3'-UTR Clone for METTL15 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL15 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL15 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for METTL15 | | OriGene Custom Protein Services for METTL15 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat METTL15 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing METTL15 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL15 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat METTL15 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL15 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL15 |
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 |  |  |  | |
| | | | Search Tocris compounds for METTL15 |
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 | | | METTL15 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL15 |
|  |  |  |  | | | | ThermoFisher Antibodies for METTL15 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL15 |
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