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Aliases for METTL15 Gene

Aliases for METTL15 Gene

  • Methyltransferase Like 15 2 3
  • Methyltransferase 5 Domain-Containing Protein 1 3 4
  • Methyltransferase 5 Domain Containing 1 2 3
  • METT5D1 3 4
  • Probable S-Adenosyl-L-Methionine-Dependent Methyltransferase METT5D1 3
  • Putative S-Adenosyl-L-Methionine-Dependent Methyltransferase METT5D1 3
  • Probable Methyltransferase-Like Protein 15 3
  • EC 2.1.1.- 4

External Ids for METTL15 Gene

Previous Symbols for METTL15 Gene

  • METT5D1

Summaries for METTL15 Gene

GeneCards Summary for METTL15 Gene

METTL15 (Methyltransferase Like 15) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity.

UniProtKB/Swiss-Prot for METTL15 Gene

  • Probable S-adenosyl-L-methionine-dependent methyltransferase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL15 Gene

Genomics for METTL15 Gene

Genomic Location for METTL15 Gene

Start:
28,108,248 bp from pter
End:
28,352,308 bp from pter
Size:
244,061 bases
Orientation:
Plus strand

Genomic View for METTL15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for METTL15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL15 Gene

No data available for Regulatory Elements for METTL15 Gene

Proteins for METTL15 Gene

  • Protein details for METTL15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NJ78-MET15_HUMAN
    Recommended name:
    Probable methyltransferase-like protein 15
    Protein Accession:
    A6NJ78
    Secondary Accessions:
    • A8MRS5
    • B7WNU2
    • Q3MHD3
    • Q8N601
    • Q8NBA7

    Protein attributes for METTL15 Gene

    Size:
    407 amino acids
    Molecular mass:
    46121 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH30997.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for METTL15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for METTL15 Gene

Proteomics data for METTL15 Gene at MOPED

Post-translational modifications for METTL15 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys352 and Lys381

Other Protein References for METTL15 Gene

No data available for DME Specific Peptides for METTL15 Gene

Domains for METTL15 Gene

Protein Domains for METTL15 Gene

UniProtKB/Swiss-Prot:

MET15_HUMAN
Family:
  • Belongs to the methyltransferase superfamily. RsmH family.:
    • A6NJ78
genes like me logo Genes that share domains with METTL15: view

No data available for Gene Families for METTL15 Gene

Function for METTL15 Gene

Molecular function for METTL15 Gene

UniProtKB/Swiss-Prot Function: Probable S-adenosyl-L-methionine-dependent methyltransferase.

Enzyme Numbers (IUBMB) for METTL15 Gene

Gene Ontology (GO) - Molecular Function for METTL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008168 methyltransferase activity --
GO:0071424 rRNA (cytosine-N4-)-methyltransferase activity IBA --
genes like me logo Genes that share ontologies with METTL15: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for METTL15 Gene

Localization for METTL15 Gene

No data available for Gene Ontology (GO) - Cellular Components for METTL15 Gene

Pathways for METTL15 Gene

SuperPathways for METTL15 Gene

No Data Available

Interacting Proteins for METTL15 Gene

Gene Ontology (GO) - Biological Process for METTL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation --
GO:0070475 rRNA base methylation IBA --
genes like me logo Genes that share ontologies with METTL15: view

No data available for Pathways by source for METTL15 Gene

Transcripts for METTL15 Gene

Unigene Clusters for METTL15 Gene

Methyltransferase like 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for METTL15 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4:

Relevant External Links for METTL15 Gene

GeneLoc Exon Structure for
METTL15
ECgene alternative splicing isoforms for
METTL15

Expression for METTL15 Gene

mRNA expression in normal human tissues for METTL15 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for METTL15 Gene

SOURCE GeneReport for Unigene cluster for METTL15 Gene Hs.243326

genes like me logo Genes that share expressions with METTL15: view

Orthologs for METTL15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METTL15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL15 36
  • 99.59 (n)
  • 99.02 (a)
METTL15 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia METTL15 36
  • 88.62 (n)
  • 86.24 (a)
METTL15 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia METTL15 36
  • 88.7 (n)
  • 86.24 (a)
METTL15 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mettl15 36
  • 80.79 (n)
  • 78.82 (a)
Mettl15 16
Mettl15 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia METTL15 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia METTL15 37
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves METTL15 36
  • 70.77 (n)
  • 67.84 (a)
METTL15 37
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia METTL15 37
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3963 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl15 36
  • 68.18 (n)
  • 68.58 (a)
Str.17107 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8699 36
zebrafish
(Danio rerio)
Actinopterygii LOC560573 36
  • 60.5 (n)
  • 58.81 (a)
METTL15 37
  • 50 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002831 36
  • 50.95 (n)
  • 49.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14683 36
  • 51.38 (n)
  • 47.08 (a)
CG14683 37
  • 44 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G10910 36
  • 47.04 (n)
  • 37.75 (a)
rice
(Oryza sativa)
Liliopsida Os02g0137600 36
  • 45.99 (n)
  • 35.44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 41 (a)
OneToOne
Species with no ortholog for METTL15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for METTL15 Gene

ENSEMBL:
Gene Tree for METTL15 (if available)
TreeFam:
Gene Tree for METTL15 (if available)

Paralogs for METTL15 Gene

Selected SIMAP similar genes for METTL15 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for METTL15 Gene

genes like me logo Genes that share paralogs with METTL15: view

No data available for Paralogs for METTL15 Gene

Variants for METTL15 Gene

Sequence variations from dbSNP and Humsavar for METTL15 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs959128 -- 28,154,633(-) ACTTG(C/T)CCAAA intron-variant
rs959529 -- 28,227,462(+) ATGAT(A/T)GTTAG intron-variant
rs960357 -- 28,153,266(-) AGAGG(C/T)ATTCG intron-variant
rs967385 -- 28,204,460(-) TTACa(A/C)aaaaa intron-variant
rs967386 -- 28,204,396(-) ATTAA(A/G)ATCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for METTL15 Gene

Variant ID Type Subtype PubMed ID
nsv832096 CNV Loss 17160897
nsv897150 CNV Loss 21882294
dgv1057n71 CNV Loss 21882294
nsv38603 CNV Loss 16902084
esv2670715 CNV Deletion 23128226

Relevant External Links for METTL15 Gene

HapMap Linkage Disequilibrium report
METTL15

Disorders for METTL15 Gene

No disorders were found for METTL15 Gene.

No data available for UniProtKB/Swiss-Prot for METTL15 Gene

Publications for METTL15 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for METTL15 Gene

Sources for METTL15 Gene

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