Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

METTL15 Gene

protein-coding   GIFtS: 46
GCID: GC11P028129

Methyltransferase Like 15

(Previous name: methyltransferase 5 domain containing 1)
(Previous symbol: METT5D1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Methyltransferase Like 151 2     Probable Methyltransferase-Like Protein 152
METT5D11 2 3     Probable S-Adenosyl-L-Methionine-Dependent Methyltransferase METT5D12
Methyltransferase 5 Domain Containing 11 2     Putative S-Adenosyl-L-Methionine-Dependent Methyltransferase METT5D12
Methyltransferase 5 Domain-Containing Protein 12 3     EC 2.1.1.-3

External Ids:    HGNC: 266061   Entrez Gene: 1960742   Ensembl: ENSG000001695197   UniProtKB: A6NJ783   

Export aliases for METTL15 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for METTL15 Gene: 
METTL15 (methyltransferase like 15) is a protein-coding gene. Diseases associated with METTL15 include pneumonia, and tuberculosis. GO annotations related to this gene include methyltransferase activity.

UniProtKB/Swiss-Prot: MET15_HUMAN, A6NJ78
Function: Probable S-adenosyl-L-methionine-dependent methyltransferase (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for METTL15
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMETTL15 promoter sequence
   Search SABiosciences Chromatin IP Primers for METTL15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p14.1   Ensembl cytogenetic band:  11p14.1   HGNC cytogenetic band: 11p14.1

METTL15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
METTL15 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P028129:  view genomic region     (about GC identifiers)

Start:
28,129,795 bp from pter      End:
28,355,054 bp from pter
Size:
225,260 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MET15_HUMAN, A6NJ78 (See protein sequence)
Recommended Name: Probable methyltransferase-like protein 15  
Size: 407 amino acids; 46121 Da
Sequence caution: Sequence=AAH30997.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8MRS5 B7WNU2 Q3MHD3 Q8N601 Q8NBA7
Alternative splicing: 4 isoforms:  A6NJ78-1   A6NJ78-2   A6NJ78-3   A6NJ78-4   

Explore the universe of human proteins at neXtProt for METTL15: NX_A6NJ78

Explore proteomics data for METTL15 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A6NJ78

  • METTL15 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    METTL15 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001107000.1  NP_689849.2  

    ENSEMBL proteins: 
     ENSP00000385507   ENSP00000385860   ENSP00000396550   ENSP00000384369   ENSP00000307251  
     ENSP00000392806   ENSP00000342259   ENSP00000368497  

    Human Recombinant Protein Products for METTL15: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for METTL15
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for METTL15
    GenScript Custom Purified and Recombinant Proteins Services for METTL15
    Novus Biologicals METTL15 Protein
    Novus Biologicals METTL15 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 


    METTL15 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for METTL15
    GenScript Custom Superior Antibodies Services for METTL15
    Novus Biologicals METTL15 Antibodies
    Abcam antibodies for METTL15
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for METTL15
    LSBio Antibodies in human, mouse, rat for METTL15 

    Assay Products for METTL15: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for METTL15
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for METTL15
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR023397 SAM-dep_MeTrfase_MraW_recog
     IPR002903 RsmH

    Graphical View of Domain Structure for InterPro Entry A6NJ78

    ProtoNet protein and cluster: A6NJ78

    UniProtKB/Swiss-Prot: MET15_HUMAN, A6NJ78
    Similarity: Belongs to the methyltransferase superfamily. RsmH family


    METTL15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MET15_HUMAN, A6NJ78
    Function: Probable S-adenosyl-L-methionine-dependent methyltransferase (By similarity)

         Enzyme Number (IUBMB): EC 2.1.1.-1

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008168methyltransferase activity IEA--
         
    METTL15 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for METTL15 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for METTL15

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for METTL15 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for METTL15 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat METTL15
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate METTL15 (see all 14):
    hsa-miR-3671 hsa-miR-653 hsa-miR-607 hsa-miR-539 hsa-miR-944 hsa-miR-138-2* hsa-miR-4282 hsa-miR-656
    SwitchGear 3'UTR luciferase reporter plasmidMETTL15 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for METTL15
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat METTL15

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for METTL15
    Sirion Biotech Customized adenovirus for overexpression of METTL15

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for METTL15 (see all 11)
    OriGene ORF clones in mouse, rat for METTL15
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): METTL15 (NM_001113528)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for METTL15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL15
    Sirion Biotech Customized lentivirus for stable overexpression of METTL15 
                         Customized lentivirus expression plasmids for stable overexpression of METTL15 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for METTL15
    Search LifeMap BioReagents cell lines for METTL15
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL15


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for METTL15

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for METTL15 (A6NJ783 ENSP000003843694) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LONRF2Q1L5Z93I2D: score=4 
    RPS20ENSP000000095894STRING: ENSP00000009589
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for METTL15 (MET15)

    Search CenterWatch for drugs/clinical trials and news about METTL15 / MET15

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for METTL15 gene (2 alternative transcripts): 
    NM_001113528.1  NM_152636.2  

    Unigene Cluster for METTL15:

    Methyltransferase like 15
    Hs.243326  [show with all ESTs]
    Unigene Representative Sequence: NM_152636
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000406787(uc001mse.2) ENST00000403099 ENST00000451385 ENST00000407364
    ENST00000303459 ENST00000437814(uc001msf.1) ENST00000468295 ENST00000342303(uc001msg.2 uc001msh.2)
    ENST00000379199
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat METTL15
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate METTL15 (see all 14):
    hsa-miR-3671 hsa-miR-653 hsa-miR-607 hsa-miR-539 hsa-miR-944 hsa-miR-138-2* hsa-miR-4282 hsa-miR-656
    SwitchGear 3'UTR luciferase reporter plasmidMETTL15 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for METTL15
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat METTL15
    Clone
    Products:
         
    OriGene clones in human, mouse for METTL15 (see all 11)
    OriGene ORF clones in mouse, rat for METTL15
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): METTL15 (NM_001113528)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for METTL15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL15
    Sirion Biotech Customized lentivirus for stable overexpression of METTL15 
                         Customized lentivirus expression plasmids for stable overexpression of METTL15 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for METTL15
    OriGene qSTAR qPCR primer pairs in human, mouse for METTL15
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat METTL15
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL15
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL15

    Additional mRNA sequence: 

    AK091261.1 AK091298.1 AL832668.1 BC030997.1 BC066900.1 BC105287.1 

    10 DOTS entries:

    DT.100021392  DT.40308369  DT.309227  DT.100745155  DT.402985  DT.430789  DT.99993289  DT.99971248 
    DT.120841679  DT.97777549 

    24/66 AceView cDNA sequences (see all 66):

    AW615337 AI569925 AL558515 AA778108 AL713720 CR601005 AI433420 BM550252 
    AA398002 BM477529 AI004348 CB107014 AI702097 BV207802 AI637581 BG721730 
    BC030997 BQ945878 AX746902 BQ437588 BE892490 BV201476 AI687680 NM_152636 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for METTL15    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
    SP1:                          -     -     -                 -           -               
    SP2:                          -     -     -                                             
    SP3:                          -     -     -                             -               
    SP4:                                                                                    


    ECgene alternative splicing isoforms for METTL15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    METTL15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGTTGGAA
    METTL15 Expression
    About this image


    See METTL15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for METTL15

    SOURCE GeneReport for Unigene cluster: Hs.243326
        SABiosciences Custom PCR Arrays for METTL15
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for METTL15
    OriGene qSTAR qPCR primer pairs in human, mouse for METTL15
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat METTL15
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL15
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL15
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for METTL15 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mettl151 , 5 methyltransferase like 151, 5 80.79(n)1
    78.82(a)1
      2 (56.52 cM)5
    768941  NM_029790.31  NP_084066.21 
     1090922975 
    chicken
    (Gallus gallus)
    Aves METTL151 methyltransferase like 15 70.86(n)
    68.01(a)
      421606  NM_001199422.1  NP_001186351.1 
    lizard
    (Anolis carolinensis)
    Reptilia METTL156
    Uncharacterized protein
    76(a)
    1 ↔ 1
    GL343314.1(841533-853481)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.39632 Xenopus laevis transcribed sequence with weak similarity more 75.19(n)    BX843120.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5605731 probable S-adenosyl-L-methionine-dependent methyltransferase more 60.48(n)
    58.98(a)
      560573  XM_683971.2  XP_689063.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG146831 CG14683 51.49(n)
    47.08(a)
      41278  NM_176455.2  NP_788632.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G109101 mraW methylase family protein 46.01(n)
    37.46(a)
      830958  NM_121129.3  NP_196652.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g01376001 hypothetical protein 44.44(n)
    35.2(a)
      4328239  NM_001052366.1  NP_001045831.1 


    ENSEMBL Gene Tree for METTL15 (if available)
    TreeFam Gene Tree for METTL15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for METTL15 gene
    1 SIMAP similar gene for METTL15 using alignment to 3 protein entries:     MET15_HUMAN (see all proteins):
    METTL15P1

    METTL15 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for METTL15
    PGOHUM00000239484 PGOHUM00000250267 PGOHUM00000241663


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3785 SNPs in METTL15 are shown (see all 3785)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0368014
    ----see VAR_0368012 N K mis40--------
    rs1911656941,2
    --28131776(+) GCGGAA/GCCAAA 2 -- ut510--------
    rs1821780411,2
    C--28131793(+) CGGTCC/GTCAGT 2 -- ut510--------
    rs1395726771,2
    --28131883(+) AGGTTC/GTCCTG 2 -- ut510--------
    rs1879449401,2
    --28132043(+) GAGCAA/GAAGAA 2 -- int10--------
    rs1443066381,2
    --28132052(+) AAAAAC/TACGCC 2 -- int10--------
    rs773630661,2
    C,F--28132109(+) AGTTTC/TCGAAT 2 -- int11Minor allele frequency- T:0.06EA 120
    rs1465446661,2
    --28132250(+) TTCAAA/GCAGGA 2 -- int10--------
    rs1409631951,2
    --28132262(+) TTCCCA/TGCCAG 2 -- int10--------
    rs1499511531,2
    --28132372(+) TGGCAA/GTTTTA 2 -- int10--------

    HapMap Linkage Disequilibrium report for METTL15 (28129795 - 28355054 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for METTL15:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2670715CNV Deletion23128226
    dgv1057n71CNV Loss21882294
    nsv897150CNV Loss21882294
    nsv38603CNV Loss16902084
    nsv832096CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing METTL15
    DNA2.0 Custom Variant and Variant Library Synthesis for METTL15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for METTL15:    About MalaCards
    pneumonia    tuberculosis


    METTL15 for disorders           About GeneDecksing


    Export disorders for METTL15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for METTL15 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with METTL15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    4. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    5. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    7. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 196074 HGNC: 26606 AceView: FLJ33979 Ensembl:ENSG00000169519 euGenes: HUgn196074
    ECgene: METTL15 H-InvDB: METTL15

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for METTL15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for METTL15 gene:
    Search GeneIP for patents involving METTL15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for METTL15  
     OriGene qPCR primer pairs and template standards for METTL15   OriGene Protein Over-expression Lysate for METTL15  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for METTL15  
     OriGene qSTAR qPCR primer pairs in human, mouse for METTL15   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for METTL15   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for METTL15   OriGene Custom Protein Services for METTL15  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat METTL15
     QIAGEN SeqTarget long-range PCR primers for resequencing METTL15
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL15
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat METTL15
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL15
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL15
     GenScript Custom Purified and Recombinant Proteins Services for METTL15 GenScript cDNA clones with any tag delivered in your preferred vector for METTL15
     GenScript Custom Assay Services for METTL15 GenScript Custom Superior Antibodies Services for METTL15
     GenScript Custom overexpressing Cell Line Services for METTL15 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Search Regulatory tfbs for METTL15
     Search Chromatin IP Primers for METTL15
     RT2 qPCR Primer Assay in human, mouse, rat METTL15
     Search GNC Networks for METTL15
     SABiosciences Custom PCR Arrays for METTL15
     Search Tocris compounds for METTL15 (MET15)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     METTL15 antibodies
     METTL15 proteins
     METTL15 lysates
     Antibodies for METTL15
     See all of Abcam's Antibodies, Kits and Proteins for METTL15
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for METTL15
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL15
     SwitchGear 3'UTR luciferase reporter plasmids for METTL15
     SwitchGear Promoter luciferase reporter plasmids for METTL15
     ThermoFisher Antibodies for METTL15
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL15
     inGenious Targeting Laboratory - Custom generated mouse model solutions for METTL15
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for METTL15
    Customized:
     lentivirus for stable overexpression of METTL15
     lentivirus expression plasmids for stable overexpression of METTL15
     adenovirus for overexpression of METTL15
     LSBio Antibodies in human, mouse, rat for METTL15
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      METTL15 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4