METTL14 Gene
protein-coding GIFtS: 48
GCID: GC04P119607
|
|
methyltransferase like 14
| |
Aliases
for METTL14 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Methyltransferase Like 141 2 | | KIAA16271 3 | | Methyltransferase-Like Protein 142 | | EC 2.1.1.-3 |
Export aliases for METTL14 gene to outside databasesPrevious GC identifers: GC04P119825 GC04P115328 |
Summaries
for METTL14 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MET14_HUMAN, Q9HCE5Function: Probable methyltransferase (By similarity)
|
Genomic Views
for METTL14 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the METTL14 gene promoter:
LHX3b/Lhx3b POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2 Cdc5 NF-AT NF-AT4 NF-AT2 NF-AT3 NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for METTL14
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL14 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q26 Ensembl cytogenetic band: 4q26 HGNC cytogenetic band: 4q26METTL14 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P119607: view genomic region
(about GC identifiers)
Start:
|
119,606,523 bp from pter |
End:
|
119,632,201 bp from pter |
Size:
|
25,679 bases |
Orientation:
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plus strand |
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Proteins
for METTL14 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MET14_HUMAN, Q9HCE5 (See
protein sequence)Recommended Name: Methyltransferase-like protein 14 Size: 456 amino acids; 52150 Da
Sequence caution: Sequence=BAB13453.1; Type=Erroneous initiation;
Secondary accessions: A6NIG1 Q969V2Explore the universe of human proteins at neXtProt for METTL14: NX_Q9HCE5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9HCE5
METTL14 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_066012.1
ENSEMBL proteins: ENSP00000373474 ENSP00000424111 ENSP00000425460
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
ISS | -- |
METTL14 for ontologies About GeneDecksing
METTL14 Antibody Products:
Assay Products for METTL14: |
Protein
Domains /
Families
for METTL14 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
METTL14 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9HCE5ProtoNet protein and cluster: Q9HCE5 1 Blocks protein family: IPB007757 MT-A70
UniProtKB/Swiss-Prot: MET14_HUMAN, Q9HCE5Similarity: Belongs to the MT-A70-like family |
Function
for METTL14 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MET14_HUMAN, Q9HCE5Function: Probable methyltransferase (By similarity)Enzyme Number (IUBMB): EC 2.1.1.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL14 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL14
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: METTL14 (NM_020961) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for METTL14 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL14 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL14 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008168 | methyltransferase activity |
-- | -- | | GO:0016422 | mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity |
ISS | -- |
METTL14 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for METTL14:
|
Pathways & Interactions
for METTL14 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for METTL14
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/17 Interacting proteins for METTL14 (Q9HCE53 ENSP000003734744) via UniProtKB, MINT, STRING, and/or I2D (see all 17)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001510 | RNA methylation |
ISS | -- | | GO:0006139 | nucleobase-containing compound metabolic process |
-- | -- |
METTL14 for ontologies About GeneDecksing
|
Drugs & Compounds
for METTL14 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for METTL14
Search CenterWatch for drugs/clinical trials and news about METTL14 / MET14
|
Transcripts
for METTL14 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for METTL14 gene: NM_020961.2 Unigene Cluster for METTL14: Methyltransferase like 14 Hs.744258 [show with all ESTs]Unigene Representative Sequence: BC0074494 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000388822(uc003icf.3) ENST00000506780 ENST00000508801 ENST00000502564
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL14 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL14
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: METTL14 (NM_020961) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for METTL14 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL14 |
Additional cDNA sequence: AB046847.1 AK055555.1 AK296056.1 BC006565.2 BC007449.2 8 DOTS entries: DT.40130889 DT.100696203 DT.100733526 DT.97802869 DT.102825324 DT.95272285 DT.95272288 DT.103999 24/127 AceView cDNA sequences (see all 127): AA789116 BU507384 BM720882 BF111931 BX105605 AA779066 BC007449 AA866199 BC006565 CB116300 AW138164 AA886975 NM_020961 AB046847 AL598989 BQ718849 CR614338 BP369273 BQ926724 BU078213 BM751433 BG220162 BX951390 AW440335
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for METTL14 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b |
|---|
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| SP1: | | | | | - | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for METTL14
|
Expression
for METTL14 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| METTL14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTAGTGCTGA
About this image
See METTL14 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for METTL14
SOURCE GeneReport for Unigene cluster: Hs.744258
SABiosciences Custom PCR Arrays for METTL14
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for METTL14
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat METTL14 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL14 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL14 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL14 |
Orthologs
for METTL14 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for METTL14 gene from 8/28 species (see all 28) About this table
ENSEMBL Gene Tree for METTL14 (if available)
TreeFam Gene Tree for METTL14 (if available) |
Paralogs
for METTL14 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for METTL14 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for METTL14
2 CNVs: 2542 3511
Human Gene Mutation Database (HGMD): METTL14
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing METTL14 |
|
Disorders
/ Diseases
for METTL14 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
METTL14 for disorders About GeneDecksing
3  diseases for METTL14: About MalaCardsalcohol dependence alcoholism malaria
Human Genome Epidemiology (HuGE) Navigator: METTL14 (1 document)
Export disorders for METTL14 gene to outside databases
|
Publications
for METTL14 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for METTL14 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with METTL14) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2, 3 Nagase T.... Ohara O. (2000)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A systematic gene-based screen of chr4q22-q32 identif ies association of a novel susceptibility gene, DKK2, with the quantitative tra it of alcohol dependence symptom counts. (PubMed id 20332099)1 Kalsi G....Riley B.P. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
|
External Searches for METTL14 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing METTL14 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing METTL14 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing METTL14 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for METTL14 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for METTL14 gene:
Search GeneIP for patents involving METTL14
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for METTL14 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for METTL14 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for METTL14 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for METTL14 | | | OriGene Protein Over-expression Lysate for METTL14 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for METTL14 | | OriGene 3'-UTR Clone for METTL14 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL14 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL14 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for METTL14 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for METTL14 | | OriGene Custom Protein Services for METTL14 | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat METTL14 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing METTL14 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL14 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat METTL14 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL14 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL14 |
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 |  |  |  | |
| | | | Search Tocris compounds for METTL14 |
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 | | | METTL14 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL14 |
|  |  |  | | | | Search ThermoFisher Antibodies for METTL14 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL14 |
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