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METTL14 Gene

protein-coding   GIFtS: 50
GCID: GC04P119636

Methyltransferase Like 14

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Methyltransferase Like 141 2
Methyltransferase-Like Protein 142 3
N6-Adenosine-Methyltransferase Subunit METTL142
EC 2.1.1.623
KIAA16273

External Ids:    HGNC: 293301   Entrez Gene: 577212   Ensembl: ENSG000001453887   UniProtKB: Q9HCE53   

Export aliases for METTL14 gene to outside databases

Previous GC identifers: GC04P119825 GC04P119607 GC04P115328 GC04P119621


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for METTL14 Gene:
METTL14 (methyltransferase like 14) is a protein-coding gene. Diseases associated with METTL14 include alcohol dependence, and malaria. GO annotations related to this gene include mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity.

UniProtKB/Swiss-Prot: MET14_HUMAN, Q9HCE5
Function: N6-methyltransferase that methylates adenosine residues of some mRNAs and acts as a regulator of the
circadian clock and self-renewal of embryonic stem cells. N6-methyladenosine (m6A), which takes place at the
5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing and processing and
mRNA stability. M6A regulates the length of the circadian clock: acts as a early pace-setter in the circadian
loop M6A also acts as a regulator of mRNA stability: in embryonic stem cells (ESCs), m6A methylation of mRNAs
encoding developmental regulators, results in transcript destabilization, maintaining the groung state of ESCs,
thereby promoting self-renewal of ESCs




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the METTL14 gene promoter:
         LHX3b/Lhx3b   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   Cdc5   NF-AT   NF-AT4   NF-AT2   NF-AT3   NF-AT1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for METTL14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat METTL14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q26   Ensembl cytogenetic band:  4q26   HGNC cytogenetic band: 4q26

METTL14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
METTL14 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P119636:  view genomic region     (about GC identifiers)

Start:
119,606,523 bp from pter      End:
119,636,588 bp from pter
Size:
30,066 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MET14_HUMAN, Q9HCE5 (See protein sequence)
Recommended Name: N6-adenosine-methyltransferase subunit METTL14  
Size: 456 amino acids; 52150 Da
Subunit: Component of the WMM complex, a N6-methyltransferase complex composed of WTAP, METTL3 and METTL14
Sequence caution: Sequence=BAB13453.1; Type=Erroneous initiation;
Secondary accessions: A6NIG1 Q969V2

Explore the universe of human proteins at neXtProt for METTL14: NX_Q9HCE5

Explore proteomics data for METTL14 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys148
  • Modification sites at PhosphoSitePlus

  • See METTL14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066012.1  
    ENSEMBL proteins: 
     ENSP00000373474   ENSP00000424111   ENSP00000425460  

    METTL14 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for METTL14
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    GenScript Custom Purified and Recombinant Proteins Services for METTL14
    Novus Biologicals METTL14 Protein
    Novus Biologicals METTL14 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for METTL14

    METTL14 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for METTL14
    Cloud-Clone Corp. Antibodies for METTL14
    Search ThermoFisher Antibodies for METTL14
    LSBio Antibodies in human, mouse, rat for METTL14

    METTL14 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for METTL14
    Cloud-Clone Corp. CLIAs for METTL14


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007757 MT-A70-like

    Graphical View of Domain Structure for InterPro Entry Q9HCE5

    ProtoNet protein and cluster: Q9HCE5

    1 Blocks protein domain: IPB007757 MT-A70

    UniProtKB/Swiss-Prot: MET14_HUMAN, Q9HCE5
    Similarity: Belongs to the MT-A70-like family


    METTL14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MET14_HUMAN, Q9HCE5
    Function: N6-methyltransferase that methylates adenosine residues of some mRNAs and acts as a regulator of the
    circadian clock and self-renewal of embryonic stem cells. N6-methyladenosine (m6A), which takes place at the
    5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing and processing and
    mRNA stability. M6A regulates the length of the circadian clock: acts as a early pace-setter in the circadian
    loop M6A also acts as a regulator of mRNA stability: in embryonic stem cells (ESCs), m6A methylation of mRNAs
    encoding developmental regulators, results in transcript destabilization, maintaining the groung state of ESCs,
    thereby promoting self-renewal of ESCs
    Catalytic activity: S-adenosyl-L-methionine + m(7)G(5')pppAm = S-adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am

         Enzyme Number (IUBMB): EC 2.1.1.621

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0008168methyltransferase activity ----
    GO:0016422mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity ISS--
         
    METTL14 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for METTL14:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for METTL14
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for METTL14

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for METTL14
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for METTL14

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate METTL14:
    hsa-miR-146a* hsa-miR-549
    SwitchGear 3'UTR luciferase reporter plasmidMETTL14 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for METTL14
    Predesigned siRNA for gene silencing in human, mouse, rat METTL14

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: METTL14 (NM_020961)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for METTL14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL14

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL14


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MET14_HUMAN, Q9HCE5: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--

    METTL14 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for METTL14
    Interactions:

        Search GeneGlobe Interaction Network for METTL14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for METTL14 (Q9HCE53 ENSP000003734744) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    METTL3Q86U443, ENSP000002987174I2D: score=5 STRING: ENSP00000298717
    MMS19Q96T763, ENSP000003598184I2D: score=1 STRING: ENSP00000359818
    TADA2AO754783, ENSP000002253964I2D: score=1 STRING: ENSP00000225396
    RQCD1Q926003, ENSP000002730644I2D: score=4 STRING: ENSP00000273064
    NUB1Q9Y5A73I2D: score=5 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001510RNA methylation ISS--
    GO:0006139nucleobase-containing compound metabolic process ----
    GO:0080009mRNA methylation ISS--

    METTL14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for METTL14 (MET14)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for METTL14 gene: 
    NM_020961.2  

    Unigene Cluster for METTL14:

    Methyltransferase like 14
    Hs.657806  [show with all ESTs]
    Unigene Representative Sequence: BC007449
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000388822(uc003icf.3) ENST00000506780 ENST00000508801 ENST00000502564

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat METTL14 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate METTL14:
    hsa-miR-146a* hsa-miR-549
    SwitchGear 3'UTR luciferase reporter plasmidMETTL14 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for METTL14
    Predesigned siRNA for gene silencing in human, mouse, rat METTL14
    Clone
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    OriGene clones in human, mouse for METTL14 (see all 7)
    OriGene ORF clones in mouse, rat for METTL14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: METTL14 (NM_020961)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for METTL14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL14
    Primer
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    OriGene qPCR primer pairs and template standards for METTL14
    OriGene qSTAR qPCR primer pairs in human, mouse for METTL14
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat METTL14
      QuantiTect SYBR Green Assays in human, mouse, rat METTL14
      QuantiFast Probe-based Assays in human, mouse, rat METTL14

    Additional mRNA sequence: 

    AB046847.1 AK055555.1 AK296056.1 BC006565.2 BC007449.2 

    8 DOTS entries:

    DT.40130889  DT.100696203  DT.100733526  DT.97802869  DT.102825324  DT.95272285  DT.95272288  DT.103999 

    Selected AceView cDNA sequences (see all 127):

    BC007449 CR614338 BP369273 BC006565 BM720882 AA779066 BU507384 BX105605 
    BF111931 AW138164 AB046847 AA789116 CB116300 NM_020961 BQ718849 AL598989 
    AA886975 AA866199 AI493856 BM988268 BE298995 BX118508 BX391612 BG182721 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for METTL14    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:              -                                                           -     -                           
    SP2:                                                                                                            
    SP3:              -                       -                                                                     
    SP4:                                                                                                            


    ECgene alternative splicing isoforms for METTL14

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    METTL14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAGTGCTGA
    METTL14 Expression
    About this image

    METTL14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    METTL14 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.657806
        Custom PCR Arrays for METTL14
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for METTL14 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mettl141 , 5 methyltransferase like 141, 5 91.23(n)1
    98.68(a)1
      3 (53.96 cM)5
    2105291  NM_201638.21  NP_964000.21 
     1233646455 
    chicken
    (Gallus gallus)
    Aves METTL141 methyltransferase like 14 83.92(n)
    94.7(a)
      422684  NM_001031148.1  NP_001026319.1 
    lizard
    (Anolis carolinensis)
    Reptilia METTL146
    methyltransferase like 14
    93(a)
    1 ↔ 1
    5(140373875-140396560)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.76342 Xenopus laevis transcribed sequence with weak similarity more 77.58(n)    BU901089.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mettl141 methyltransferase like 14 72.74(n)
    84.81(a)
      404603  NM_207071.1  NP_996954.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG78181 CG7818 59.91(n)
    67.4(a)
      34138  NM_135361.3  NP_609205.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KAR41 KAR4 46.34(n)
    30.3(a)
      850303   NP_009876.1 
    soybean
    (Glycine max)
    eudicotyledons Gma.104862 Transcribed sequence with strong similarity to protein more 74.08(n)    BM188576.1 
    rice
    (Oryza sativa)
    Liliopsida Os.225082 Oryza sativa (japonica cultivar-group) cDNA clone0 more 73.03(n)    AK065023.1 


    ENSEMBL Gene Tree for METTL14 (if available)
    TreeFam Gene Tree for METTL14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for METTL14 (see all 536)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs782706391,2
    C,F--115326344(+) GAGCAA/CAAAGG 1 -- us2k11Minor allele frequency- C:0.08EA 120
    rs1139884201,2
    F--115326454(+) GCAAAC/TTCACT 1 -- us2k12Minor allele frequency- T:0.50CSA 4
    rs1860843211,2
    --115326502(+) GAGGGG/TCTGCT 1 -- us2k10--------
    rs2989831,2
    C,F,A--115326544(-) AGAGCA/GATGAC 1 -- us2k111Minor allele frequency- G:0.41NA WA CSA EA 374
    rs1464942161,2
    --115326603(+) TTCCAC/TCTTTT 1 -- us2k10--------
    rs1399622831,2
    --115326637(+) GGGCAA/GAGTCT 1 -- us2k10--------
    rs1152063711,2
    C--115326734(+) AGTATA/GGGGTT 1 -- us2k10--------
    rs2989821,2
    C,F,O,A,H--115326751(-) CTTGCC/TTGTAA 1 -- us2k1 tfbs319Minor allele frequency- T:0.26EA NA NS WA CSA 1004
    rs98849781,2
    C,F,A--115326786(+) AAAAAG/AAAAAA 1 -- us2k1 trp36Minor allele frequency- A:0.30NA WA 144
    rs2009713181,2
    --115326786(+) AAAAA-/GAAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for METTL14 (119606523 - 119636588 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for METTL14:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv519017CNV Loss19592680
    essv11621CNV CNV17122850
    dgv1668e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): METTL14
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing METTL14
    DNA2.0 Custom Variant and Variant Library Synthesis for METTL14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for METTL14:    
    About MalaCards
    alcohol dependence    malaria


    METTL14 for disorders           About GeneDecksing

    Genetic Association Database (GAD): METTL14
    Human Genome Epidemiology (HuGE) Navigator: METTL14 (1 document)

    Export disorders for METTL14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for METTL14 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with METTL14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. A METTL3-METTL14 complex mediates mammalian nuclear RNA N-adenosine methylation. (PubMed id 24316715)1, 2 Liu J.... He C. (Nat. Chem. Biol. 2014)
    3. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (Hum. Mol. Genet. 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. (PubMed id 24407421)2 Ping X.L.... Yang Y.G. (Cell Res. 2014)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57721 HGNC: 29330 AceView: KIAA1627 Ensembl:ENSG00000145388 euGenes: HUgn57721
    ECgene: METTL14 H-InvDB: METTL14

    (According to HUGE)
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    HUGE: KIAA1627

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for METTL14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for METTL14 gene:
    Search GeneIP for patents involving METTL14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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