METTL13 Gene
protein-coding GIFtS: 50
GCID: GC01P171750
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|
methyltransferase like 13(Previous name: KIAA0859 )
(Previous symbol: KIAA0859)
| |
Aliases
for METTL13 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Methyltransferase Like 131 2 | | Antiapoptotic Protein FEAT2 | | KIAA08591 2 3 | | Feat1 | | CGI-011 | | Methyltransferase-Like Protein 132 | | 5630401D24Rik2 | | EC 2.1.1.-3 |
Export aliases for METTL13 gene to outside databasesPrevious GC identifers: GC01P170018 GC01P142974 |
Summaries
for METTL13 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for METTL13 (KIAA0859)
|
Genomic Views
for METTL13 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the METTL13 gene promoter:
SRF c-Fos AP-1 MIF-1 AP-2gamma Roaz MZF-1 Zic1 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for METTL13
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL13 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q24-q25.3 Ensembl cytogenetic band: 1q24.3 HGNC cytogenetic band: 1q24-q25.3METTL13 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P171750: view genomic region
(about GC identifiers)
Start:
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171,750,761 bp from pter |
End:
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171,783,163 bp from pter |
Size:
|
32,403 bases |
Orientation:
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plus strand |
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Proteins
for METTL13 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MET13_HUMAN, Q8N6R0 (See
protein sequence)Recommended Name: Methyltransferase-like protein 13 Size: 699 amino acids; 78768 Da
Sequence caution: Sequence=BAA74882.2; Type=Erroneous initiation; Sequence=BAD97213.1; Type=Erroneous initiation;
Secondary accessions: A6NFK0 A8K6S5 O94940 Q53EZ6 Q5TGP9 Q5TGQ0 Q8N2P8 Q96J11 Q96SQ0 Q9Y2Z1 Q9Y3M6Alternative splicing: 5 isoforms: Q8N6R0-5 Q8N6R0-4 Q8N6R0-3 Q8N6R0-1 Q8N6R0-2 Explore the universe of human proteins at neXtProt for METTL13: NX_Q8N6R0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N6R0
METTL13 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001007240.1 NP_055770.1 NP_057019.3
ENSEMBL proteins: ENSP00000355393 ENSP00000356711 ENSP00000354920 ENSP00000356710 ENSP00000401955
Human Recombinant Protein Products:
METTL13 Antibody Products:
Assay Products for METTL13: |
Protein
Domains /
Families
for METTL13 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
METTL13 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8N6R0ProtoNet protein and cluster: Q8N6R0 1 Blocks protein family: IPB013216 Methyltransferase type 11
UniProtKB/Swiss-Prot: MET13_HUMAN, Q8N6R0Similarity: Belongs to the methyltransferase superfamily |
Function
for METTL13 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Enzyme Number (IUBMB): EC 2.1.1.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL13 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL13 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): METTL13 (NM_014955) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for METTL13 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL13 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL13 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008168 | methyltransferase activity |
IEA | -- |
METTL13 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for METTL13:
|
Pathways & Interactions
for METTL13 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for METTL13
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5/561 Interacting proteins for METTL13 (Q8N6R02, 3 ENSP000003549204) via UniProtKB, MINT, STRING, and/or I2D (see all 561)About this table
|
Drugs & Compounds
for METTL13 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for METTL13
Search CenterWatch for drugs/clinical trials and news about METTL13 / MET13
|
Transcripts
for METTL13 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for METTL13 gene (3 alternative transcripts): NM_001007239.1 NM_014955.2 NM_015935.4 Unigene Cluster for METTL13: Methyltransferase like 13 Hs.494705 [show with all ESTs]Unigene Representative Sequence: NM_0159359 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000485629 ENST00000362019(uc001gia.3) ENST00000367737(uc001gib.3)
ENST00000361735(uc001ghz.3 uc010pml.2) ENST00000367736 ENST00000478330
ENST00000466643 ENST00000476386 ENST00000458517
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL13 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL13 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): METTL13 (NM_014955) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for METTL13 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL13 |
Additional cDNA sequence: AB020666.2 AB242174.1 AB242175.1 AF132936.1 AK001172.1 AK027552.1 AK027621.1 AK027886.1 AK074552.1 AK129561.1 AK223493.1 AK291740.1 AK304471.1 AL049669.1 BC006814.1 BC029083.1 13 DOTS entries: DT.100791536 DT.95227710 DT.95227707 DT.99933323 DT.315359 DT.97848272 DT.95133741 DT.100791534 DT.121462685 DT.121462755 DT.100728579 DT.121462695 DT.121462742 24/296 AceView cDNA sequences (see all 296): BE302190 BC029083 BU844583 AI824580 BU931456 BC006814 CB133991 CB126290 H89315 AA600908 AK027621 AL049669 CR595608 BM661479 BQ434990 BE222896 F27871 AA885715 BQ691144 AK094818 BU171924 AI364370 CR594527 CD656212
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for METTL13 (see all 9) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for METTL13
|
Expression
for METTL13 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| METTL13 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGACCTCCAG
About this image
See METTL13 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for METTL13
SOURCE GeneReport for Unigene cluster: Hs.494705
SABiosciences Custom PCR Arrays for METTL13
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for METTL13
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat METTL13 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL13 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL13 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL13 |
Orthologs
for METTL13 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for METTL13 gene from 9/27 species (see all 27) About this table
ENSEMBL Gene Tree for METTL13 (if available)
TreeFam Gene Tree for METTL13 (if available) |
Paralogs
for METTL13 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for METTL13 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for METTL13 (171750761 - 171783163 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for METTL13
1 Indel: 59964 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing METTL13 |
|
Disorders
/ Diseases
for METTL13 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
METTL13 for disorders About GeneDecksing
3  diseases for METTL13: About MalaCardsexhibitionism smallpox malaria
1 disease from the University of Copenhagen DISEASES database for METTL13:Exhibitionism Export disorders for METTL13 gene to outside databases
|
Publications
for METTL13 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for METTL13 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with METTL13) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
- Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T....Ohara O. (1998)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
- Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A novel potent tumour promoter aberrantly overexpresse d in most human cancers. (PubMed id 22355534)1 Takahashi A....Tani K. (2011)
|
External Searches for METTL13 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing METTL13 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing METTL13 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing METTL13 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for METTL13 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for METTL13 gene:
Search GeneIP for patents involving METTL13
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for METTL13 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for METTL13 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for METTL13 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for METTL13 | | | OriGene Protein Over-expression Lysate for METTL13 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for METTL13 | | OriGene 3'-UTR Clone for METTL13 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL13 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL13 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for METTL13 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for METTL13 | | OriGene Custom Protein Services for METTL13 | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat METTL13 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing METTL13 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL13 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat METTL13 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL13 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL13 |
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| | | | Search Tocris compounds for METTL13 |
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 | | | METTL13 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL13 |
|  |  |  | | | | Search ThermoFisher Antibodies for METTL13 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL13 |
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