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Aliases for METTL13 Gene

Aliases for METTL13 Gene

  • Methyltransferase Like 13 2 3 5
  • KIAA0859 2 3 4
  • Antiapoptotic Protein FEAT 3
  • 5630401D24Rik 3
  • EC 2.1.1.- 4
  • CGI-01 3
  • Feat 3

External Ids for METTL13 Gene

Previous HGNC Symbols for METTL13 Gene

  • KIAA0859

Previous GeneCards Identifiers for METTL13 Gene

  • GC01P170018
  • GC01P171750
  • GC01P142974

Summaries for METTL13 Gene

GeneCards Summary for METTL13 Gene

METTL13 (Methyltransferase Like 13) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity.

Gene Wiki entry for METTL13 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL13 Gene

Genomics for METTL13 Gene

Regulatory Elements for METTL13 Gene

Enhancers for METTL13 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around METTL13 on UCSC Golden Path with GeneCards custom track

Promoters for METTL13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around METTL13 on UCSC Golden Path with GeneCards custom track

Genomic Location for METTL13 Gene

Chromosome:
1
Start:
171,781,621 bp from pter
End:
171,814,023 bp from pter
Size:
32,403 bases
Orientation:
Plus strand

Genomic View for METTL13 Gene

Genes around METTL13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL13 Gene

Proteins for METTL13 Gene

  • Protein details for METTL13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6R0-MET13_HUMAN
    Recommended name:
    Methyltransferase-like protein 13
    Protein Accession:
    Q8N6R0
    Secondary Accessions:
    • A6NFK0
    • A8K6S5
    • O94940
    • Q53EZ6
    • Q5TGP9
    • Q5TGQ0
    • Q8N2P8
    • Q96J11
    • Q96SQ0
    • Q9Y2Z1
    • Q9Y3M6

    Protein attributes for METTL13 Gene

    Size:
    699 amino acids
    Molecular mass:
    78768 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA74882.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD97213.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for METTL13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for METTL13 Gene

Proteomics data for METTL13 Gene at MOPED

Post-translational modifications for METTL13 Gene

  • Ubiquitination at Lys 19, Lys 252, and Lys 207
  • Modification sites at PhosphoSitePlus

Other Protein References for METTL13 Gene

No data available for DME Specific Peptides for METTL13 Gene

Domains & Families for METTL13 Gene

Gene Families for METTL13 Gene

Protein Domains for METTL13 Gene

Suggested Antigen Peptide Sequences for METTL13 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N6R0

UniProtKB/Swiss-Prot:

MET13_HUMAN :
  • Belongs to the methyltransferase superfamily.
Family:
  • Belongs to the methyltransferase superfamily.
genes like me logo Genes that share domains with METTL13: view

Function for METTL13 Gene

Enzyme Numbers (IUBMB) for METTL13 Gene

Gene Ontology (GO) - Molecular Function for METTL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with METTL13: view

Phenotypes for METTL13 Gene

genes like me logo Genes that share phenotypes with METTL13: view

Animal Model Products

CRISPR Products

miRNA for METTL13 Gene

miRTarBase miRNAs that target METTL13

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL13 Gene

Localization for METTL13 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for METTL13 Gene COMPARTMENTS Subcellular localization image for METTL13 gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for METTL13 Gene

Pathways & Interactions for METTL13 Gene

SuperPathways for METTL13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for METTL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with METTL13: view

No data available for Pathways by source and SIGNOR curated interactions for METTL13 Gene

Drugs & Compounds for METTL13 Gene

No Compound Related Data Available

Transcripts for METTL13 Gene

Unigene Clusters for METTL13 Gene

Methyltransferase like 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for METTL13 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: -
SP2: - - -
SP3: - - - -
SP4: -
SP5: - -
SP6: - - - - -
SP7: -
SP8: - - - - -
SP9:

Relevant External Links for METTL13 Gene

GeneLoc Exon Structure for
METTL13
ECgene alternative splicing isoforms for
METTL13

Expression for METTL13 Gene

mRNA expression in normal human tissues for METTL13 Gene

Protein differential expression in normal tissues from HIPED for METTL13 Gene

This gene is overexpressed in Lymph node (14.0), Plasma (13.3), Peripheral blood mononuclear cells (9.5), and Fetal ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for METTL13 Gene



SOURCE GeneReport for Unigene cluster for METTL13 Gene Hs.494705

genes like me logo Genes that share expression patterns with METTL13: view

Protein tissue co-expression partners for METTL13 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for METTL13 Gene

Orthologs for METTL13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METTL13 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia METTL13 35
  • 91.21 (n)
  • 93.12 (a)
METTL13 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia METTL13 35
  • 90.74 (n)
  • 93.84 (a)
-- 36
  • 93 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mettl13 35
  • 87.57 (n)
  • 90.24 (a)
Mettl13 16
Mettl13 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia METTL13 35
  • 99.57 (n)
  • 99.57 (a)
METTL13 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mettl13 35
  • 88.38 (n)
  • 89.96 (a)
oppossum
(Monodelphis domestica)
Mammalia METTL13 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia METTL13 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves METTL13 35
  • 71.14 (n)
  • 69.83 (a)
METTL13 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia METTL13 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl13 35
  • 62.34 (n)
  • 61.33 (a)
zebrafish
(Danio rerio)
Actinopterygii mettl13 35
  • 57.12 (n)
  • 55.26 (a)
mettl13 36
  • 53 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.674 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008472 35
  • 51.83 (n)
  • 45.86 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2614 35
  • 52.81 (n)
  • 46.25 (a)
CG2614 36
  • 44 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_C01B10.8 35
  • 43.97 (n)
  • 37.16 (a)
C01B10.8 36
  • 36 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G31740 35
  • 45.25 (n)
  • 36.21 (a)
rice
(Oryza sativa)
Liliopsida Os04g0379300 35
  • 44.51 (n)
  • 35.01 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToOne
Species with no ortholog for METTL13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL13 Gene

ENSEMBL:
Gene Tree for METTL13 (if available)
TreeFam:
Gene Tree for METTL13 (if available)

Paralogs for METTL13 Gene

(1) SIMAP similar genes for METTL13 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with METTL13: view

No data available for Paralogs for METTL13 Gene

Variants for METTL13 Gene

Sequence variations from dbSNP and Humsavar for METTL13 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2232816 - 171,783,899(+) TGGAC(A/G)TGACG reference, missense
rs2232819 - 171,786,042(+) GTCAT(A/G/T)GAGCT reference, missense
VAR_064730 -
rs7860 -- 171,797,556(+) AGTTA(A/G)TGTGT utr-variant-3-prime
rs7967 -- 171,797,368(+) TGTCT(C/T)TTTCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for METTL13 Gene

Variant ID Type Subtype PubMed ID
nsv872545 CNV Loss 21882294
nsv522889 CNV Loss 19592680
nsv518222 CNV Loss 19592680
esv5613 CNV Gain 19470904

Variation tolerance for METTL13 Gene

Residual Variation Intolerance Score: 8.26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.02; 92.10% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for METTL13 Gene

Disorders for METTL13 Gene

Relevant External Links for METTL13

Genetic Association Database (GAD)
METTL13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
METTL13

No disorders were found for METTL13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL13 Gene

Publications for METTL13 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 67
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3
  3. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for METTL13 Gene

Sources for METTL13 Gene

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