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Aliases for METTL13 Gene

Aliases for METTL13 Gene

  • Methyltransferase Like 13 2 3 5
  • KIAA0859 2 3 4
  • Methyltransferase-Like Protein 13 3
  • Antiapoptotic Protein FEAT 3
  • 5630401D24Rik 3
  • EC 2.1.1.- 4
  • CGI-01 3
  • Feat 3

External Ids for METTL13 Gene

Previous HGNC Symbols for METTL13 Gene

  • KIAA0859

Previous GeneCards Identifiers for METTL13 Gene

  • GC01P170018
  • GC01P171750
  • GC01P142974

Summaries for METTL13 Gene

GeneCards Summary for METTL13 Gene

METTL13 (Methyltransferase Like 13) is a Protein Coding gene. Diseases associated with METTL13 include Deafness, Autosomal Recessive 26. Gene Ontology (GO) annotations related to this gene include methyltransferase activity.

Gene Wiki entry for METTL13 Gene

Additional gene information for METTL13 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL13 Gene

Genomics for METTL13 Gene

GeneHancer (GH) Regulatory Elements for METTL13 Gene

Promoters and enhancers for METTL13 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I171779 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 606 -0.2 -221 2.9 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 METTL13 PRRC2C PIGC MYOC DNM3 LOC105371614
GH01I171738 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 46 -40.2 -40192 6.2 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 VAMP4 PRRC2C METTL13 PIGC FMO4 SUCO MYOC PIR43253
GH01I172531 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.4 +751.7 751713 4.3 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 SUCO GC01M172532 PIGC METTL13
GH01I172443 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.2 +662.3 662259 1.7 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B E2F8 ZNF143 DEK PIGC PRRC2C METTL13 LOC102724528 C1orf105
GH01I172448 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 10.8 +669.7 669650 6.4 PKNOX1 CLOCK FOXA2 ARID4B FEZF1 DMAP1 ZNF2 YY1 ZNF766 ZNF143 C1orf105 PIGC SUCO METTL13 LOC102724528
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around METTL13 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the METTL13 gene promoter:

Genomic Locations for METTL13 Gene

Genomic Locations for METTL13 Gene
chr1:171,781,621-171,814,023
(GRCh38/hg38)
Size:
32,403 bases
Orientation:
Plus strand
chr1:171,750,761-171,783,163
(GRCh37/hg19)

Genomic View for METTL13 Gene

Genes around METTL13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL13 Gene

Proteins for METTL13 Gene

  • Protein details for METTL13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6R0-MET13_HUMAN
    Recommended name:
    Methyltransferase-like protein 13
    Protein Accession:
    Q8N6R0
    Secondary Accessions:
    • A6NFK0
    • A8K6S5
    • O94940
    • Q53EZ6
    • Q5TGP9
    • Q5TGQ0
    • Q8N2P8
    • Q96J11
    • Q96SQ0
    • Q9Y2Z1
    • Q9Y3M6

    Protein attributes for METTL13 Gene

    Size:
    699 amino acids
    Molecular mass:
    78768 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA74882.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD97213.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for METTL13 Gene

    Alternative splice isoforms for METTL13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for METTL13 Gene

Post-translational modifications for METTL13 Gene

  • Ubiquitination at posLast=1919, isoforms=5, 4, 3252, and isoforms=5, 4207

No data available for DME Specific Peptides for METTL13 Gene

Domains & Families for METTL13 Gene

Gene Families for METTL13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for METTL13 Gene

Suggested Antigen Peptide Sequences for METTL13 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N6R0

UniProtKB/Swiss-Prot:

MET13_HUMAN :
  • Belongs to the methyltransferase superfamily.
Family:
  • Belongs to the methyltransferase superfamily.
genes like me logo Genes that share domains with METTL13: view

Function for METTL13 Gene

Enzyme Numbers (IUBMB) for METTL13 Gene

Gene Ontology (GO) - Molecular Function for METTL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with METTL13: view

Phenotypes for METTL13 Gene

genes like me logo Genes that share phenotypes with METTL13: view

miRNA for METTL13 Gene

miRTarBase miRNAs that target METTL13

Clone Products

No data available for Molecular function , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL13 Gene

Localization for METTL13 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL13 gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for METTL13 Gene

Pathways & Interactions for METTL13 Gene

SuperPathways for METTL13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for METTL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL13: view

No data available for Pathways by source and SIGNOR curated interactions for METTL13 Gene

Drugs & Compounds for METTL13 Gene

No Compound Related Data Available

Transcripts for METTL13 Gene

Unigene Clusters for METTL13 Gene

Methyltransferase like 13:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL13 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: -
SP2: - - -
SP3: - - - -
SP4: -
SP5: - -
SP6: - - - - -
SP7: -
SP8: - - - - -
SP9:

Relevant External Links for METTL13 Gene

GeneLoc Exon Structure for
METTL13
ECgene alternative splicing isoforms for
METTL13

Expression for METTL13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for METTL13 Gene

Protein differential expression in normal tissues from HIPED for METTL13 Gene

This gene is overexpressed in Lymph node (14.0), Plasma (13.3), Peripheral blood mononuclear cells (9.5), and Fetal ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for METTL13 Gene



Protein tissue co-expression partners for METTL13 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of METTL13 Gene:

METTL13

SOURCE GeneReport for Unigene cluster for METTL13 Gene:

Hs.494705

Evidence on tissue expression from TISSUES for METTL13 Gene

  • Nervous system(4.9)
  • Liver(4.2)
  • Skin(2.3)
genes like me logo Genes that share expression patterns with METTL13: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL13 Gene

Orthologs for METTL13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METTL13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL13 33 34
  • 99.57 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 93 (a)
OneToMany
-- 34
  • 93 (a)
OneToMany
METTL13 33
  • 90.74 (n)
cow
(Bos Taurus)
Mammalia METTL13 33 34
  • 91.21 (n)
rat
(Rattus norvegicus)
Mammalia Mettl13 33
  • 88.38 (n)
mouse
(Mus musculus)
Mammalia Mettl13 33 16 34
  • 87.57 (n)
oppossum
(Monodelphis domestica)
Mammalia METTL13 34
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia METTL13 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves METTL13 33 34
  • 71.14 (n)
lizard
(Anolis carolinensis)
Reptilia METTL13 34
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl13 33
  • 62.34 (n)
zebrafish
(Danio rerio)
Actinopterygii mettl13 33 34
  • 57.12 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.674 33
fruit fly
(Drosophila melanogaster)
Insecta CG2614 33 34
  • 52.81 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008472 33
  • 51.83 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_C01B10.8 33
  • 43.97 (n)
C01B10.8 34
  • 36 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G31740 33
  • 45.25 (n)
rice
(Oryza sativa)
Liliopsida Os04g0379300 33
  • 44.51 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 39 (a)
OneToOne
Species where no ortholog for METTL13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL13 Gene

ENSEMBL:
Gene Tree for METTL13 (if available)
TreeFam:
Gene Tree for METTL13 (if available)

Paralogs for METTL13 Gene

(1) SIMAP similar genes for METTL13 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with METTL13: view

No data available for Paralogs for METTL13 Gene

Variants for METTL13 Gene

Sequence variations from dbSNP and Humsavar for METTL13 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000108980 -- 171,784,240(+) T/A coding_sequence_variant, intron_variant, synonymous_variant
rs1000170356 -- 171,797,168(+) A/G 3_prime_UTR_variant, intron_variant
rs1000177238 -- 171,783,097(+) T/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000193378 -- 171,802,781(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000228900 -- 171,783,960(+) A/G coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for METTL13 Gene

Variant ID Type Subtype PubMed ID
esv5613 CNV gain 19470904
nsv518222 CNV loss 19592680
nsv522889 CNV loss 19592680

Variation tolerance for METTL13 Gene

Residual Variation Intolerance Score: 8.26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.02; 92.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for METTL13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
METTL13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL13 Gene

Disorders for METTL13 Gene

MalaCards: The human disease database

(1) MalaCards diseases for METTL13 Gene - From: DISEASES

Disorder Aliases PubMed IDs
deafness, autosomal recessive 26
  • dfnb26
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for METTL13

genes like me logo Genes that share disorders with METTL13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for METTL13 Gene

Publications for METTL13 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for METTL13 Gene

Sources for METTL13 Gene

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