METTL12 Gene
protein-coding GIFtS: 33
GCID: GC11P062434
|
|
methyltransferase like 12
| |
Aliases
for METTL12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Methyltransferase Like 121 2 | | U99HG1 2 | | Methyltransferase-Like Protein 12, Mitochondrial2 | | Putative Methyltransferase LOC751071, Mitochondrial2 | | EC 2.1.1.-3 |
Export aliases for METTL12 gene to outside databasesPrevious GC identifers: GC11P062199 GC11P062201 GC11P062433 GC11P058761 |
Summaries
for METTL12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MET12_HUMAN, A8MUP2Function: Putative methyltransferase (By similarity)
|
Genomic Views
for METTL12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the METTL12 gene promoter:
TBP Max1 NF-1 Sp1 AP-4 POU6F1 (c2) LUN-1 C/EBPalpha PPAR-alpha RORalpha1
Other transcription factors
Search SABiosciences Chromatin IP Primers for METTL12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q12.3 Ensembl cytogenetic band: 11q12.3 HGNC cytogenetic band: 11q12.3METTL12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P062434: view genomic region
(about GC identifiers)
Start:
|
62,432,779 bp from pter |
End:
|
62,435,968 bp from pter |
Size:
|
3,190 bases |
Orientation:
|
plus strand |
|
Proteins
for METTL12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MET12_HUMAN, A8MUP2 (See
protein sequence)Recommended Name: Methyltransferase-like protein 12, mitochondrial precursor Size: 240 amino acids; 25910 Da
Subcellular location: Mitochondrion (Potential)
Secondary accessions: B7Z4C1Explore the universe of human proteins at neXtProt for METTL12: NX_A8MUP2
METTL12 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001036694.1
ENSEMBL proteins: ENSP00000431287
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- |
METTL12 for ontologies About GeneDecksing
METTL12 Antibody Products:
Assay Products for METTL12: |
Protein
Domains /
Families
for METTL12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
METTL12 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry A8MUP2ProtoNet protein and cluster: A8MUP2 UniProtKB/Swiss-Prot: MET12_HUMAN, A8MUP2Similarity: Belongs to the methyltransferase superfamily |
Function
for METTL12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MET12_HUMAN, A8MUP2Function: Putative methyltransferase (By similarity)Enzyme Number (IUBMB): EC 2.1.1.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL12
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: METTL12 (NM_001043229) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for METTL12 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL12 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL12 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008168 | methyltransferase activity |
IEA | -- |
METTL12 for ontologies About GeneDecksing
|
Pathways & Interactions
for METTL12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for METTL12
|
Drugs & Compounds
for METTL12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for METTL12
Search CenterWatch for drugs/clinical trials and news about METTL12 / MET12
|
Transcripts
for METTL12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for METTL12 gene: NM_001043229.1 Unigene Cluster for METTL12: Methyltransferase like 12 Hs.640726 [show with all ESTs]Unigene Representative Sequence: BC0413593 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000398922(uc010rmc.1) ENST00000532971(uc001nug.1) ENST00000529868(uc001nuh.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL12
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: METTL12 (NM_001043229) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for METTL12 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL12 |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for METTL12
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat METTL12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL12 |
Additional cDNA sequence: AK297138.1 BC041359.1 BC147001.1 BC147011.1 BC171895.1 7 DOTS entries: DT.40304578 DT.100020890 DT.91821358 DT.100776698 DT.40131499 DT.100020891 DT.120710060
GeneLoc Exon Structure
|
Expression
for METTL12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| METTL12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGATGCTGTT
About this image
Genevestigator expression for METTL12
SOURCE GeneReport for Unigene cluster: Hs.640726
SABiosciences Custom PCR Arrays for METTL12
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for METTL12
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat METTL12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL12 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL12 |
Orthologs
for METTL12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for METTL12 gene from 1/6 species (see all 6) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:1133051 |
zgc:113305 |
51.33(n)
45(a) |
|
553815 NM_001020777.1 NP_001018613.1 |
Species with no ortholog for METTL12
ENSEMBL Gene Tree for METTL12 (if available)
TreeFam Gene Tree for METTL12 (if available) |
Paralogs
for METTL12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for METTL12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for METTL12
1 CNV: 4749 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing METTL12 |
|
Disorders
/ Diseases
for METTL12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for METTL12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for METTL12 gene integrated from 9 sources:
(articles sorted by number of sources associating them with METTL12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)1, 2 Taylor T.D....Sakaki Y. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. (PubMed id 16368877)1 Choy K.W....Pang C.P. (2006)
- Mammalian small nucleolar RNAs are mobile genetic elements. (PubMed id 17154719)1 Weber M.J. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for METTL12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing METTL12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing METTL12 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing METTL12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for METTL12 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for METTL12 gene:
Search GeneIP for patents involving METTL12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for METTL12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for METTL12 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for METTL12 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for METTL12 | | | OriGene Protein Over-expression Lysate for METTL12 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for METTL12 | | OriGene 3'-UTR Clone for METTL12 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL12 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL12 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for METTL12 | | OriGene Custom Protein Services for METTL12 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat METTL12 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing METTL12 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL12 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat METTL12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL12 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for METTL12 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | METTL12 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL12 |
|  |  |  | | | | Search ThermoFisher Antibodies for METTL12 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL12 |
|
|
|
|
