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Aliases for METTL12 Gene

Aliases for METTL12 Gene

  • Methyltransferase Like 12 2 3 5
  • Putative Methyltransferase LOC751071, Mitochondrial 3
  • Methyltransferase-Like Protein 12, Mitochondrial 3
  • EC 2.1.1.- 4
  • U99HG 3

External Ids for METTL12 Gene

Previous GeneCards Identifiers for METTL12 Gene

  • GC11P062199
  • GC11P062201
  • GC11P062433
  • GC11P058761
  • GC11P062434
  • GC11P062436
  • GC11P062440

Summaries for METTL12 Gene

GeneCards Summary for METTL12 Gene

METTL12 (Methyltransferase Like 12) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity.

UniProtKB/Swiss-Prot for METTL12 Gene

  • Putative methyltransferase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL12 Gene

Genomics for METTL12 Gene

Regulatory Elements for METTL12 Gene

Enhancers for METTL12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F062041 1.4 Ensembl ENCODE 93 -619.8 -619836 8.1 MLX CREB3L1 ZFP64 DMAP1 FEZF1 YY1 ZNF143 SP3 NFYC MEF2D METTL12 INTS5 SNHG1 NXF1 TMEM138 LOC105369332 VPS37C EML3 MTA2 TAF6L
GH11F062838 1.2 ENCODE 54.6 +175.6 175583 4.8 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 METTL12 UBXN1 LRRN4CL NXF1 TAF6L INTS5 IMMP1LP1 SNHG1 TTC9C STX5
GH11F062852 1.5 FANTOM5 ENCODE 39.1 +190.6 190575 5.9 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC METTL12 INTS5 NXF1 SNHG1 UBXN1 MTA2 EML3 MIR6748 LOC105369332 STX5
GH11F061960 1.6 FANTOM5 ENCODE 28.2 -696.3 -696340 16.4 CREB3L1 MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC INTS5 UBXN1 METTL12 NXF1 TTC9C MTA2 TMEM138 EML3 STX5 BEST1
GH11F062651 1.2 ENCODE 31.9 -12.4 -12433 2.3 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 EML3 METTL12 INTS5 MTA2 NXF1 STX5 SNHG1 TAF6L LOC105369332 MIR6748
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around METTL12 on UCSC Golden Path with GeneCards custom track

Genomic Location for METTL12 Gene

Chromosome:
11
Start:
62,665,263 bp from pter
End:
62,668,496 bp from pter
Size:
3,234 bases
Orientation:
Plus strand

Genomic View for METTL12 Gene

Genes around METTL12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL12 Gene

Proteins for METTL12 Gene

  • Protein details for METTL12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MUP2-MET12_HUMAN
    Recommended name:
    Methyltransferase-like protein 12, mitochondrial
    Protein Accession:
    A8MUP2
    Secondary Accessions:
    • B7Z4C1

    Protein attributes for METTL12 Gene

    Size:
    240 amino acids
    Molecular mass:
    25910 Da
    Quaternary structure:
    No Data Available

neXtProt entry for METTL12 Gene

Post-translational modifications for METTL12 Gene

No Post-translational modifications

Other Protein References for METTL12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for METTL12 Gene

Domains & Families for METTL12 Gene

Gene Families for METTL12 Gene

Protein Domains for METTL12 Gene

Suggested Antigen Peptide Sequences for METTL12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A8MUP2

UniProtKB/Swiss-Prot:

MET12_HUMAN :
  • Belongs to the methyltransferase superfamily.
Family:
  • Belongs to the methyltransferase superfamily.
genes like me logo Genes that share domains with METTL12: view

Function for METTL12 Gene

Molecular function for METTL12 Gene

UniProtKB/Swiss-Prot Function:
Putative methyltransferase.

Enzyme Numbers (IUBMB) for METTL12 Gene

Gene Ontology (GO) - Molecular Function for METTL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with METTL12: view

Phenotypes for METTL12 Gene

GenomeRNAi human phenotypes for METTL12:
genes like me logo Genes that share phenotypes with METTL12: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL12 Gene

Localization for METTL12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL12 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL12 gene
Compartment Confidence
mitochondrion 4
nucleus 3
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for METTL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with METTL12: view

Pathways & Interactions for METTL12 Gene

SuperPathways for METTL12 Gene

No Data Available

Interacting Proteins for METTL12 Gene

Gene Ontology (GO) - Biological Process for METTL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL12: view

No data available for Pathways by source and SIGNOR curated interactions for METTL12 Gene

Transcripts for METTL12 Gene

mRNA/cDNA for METTL12 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for METTL12 Gene

Methyltransferase like 12:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL12 Gene

No ASD Table

Relevant External Links for METTL12 Gene

GeneLoc Exon Structure for
METTL12
ECgene alternative splicing isoforms for
METTL12

Expression for METTL12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for METTL12 Gene

NURSA nuclear receptor signaling pathways regulating expression of METTL12 Gene:

METTL12

SOURCE GeneReport for Unigene cluster for METTL12 Gene:

Hs.640726
genes like me logo Genes that share expression patterns with METTL12: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for METTL12 Gene

Orthologs for METTL12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for METTL12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL12 34 35
  • 99.17 (n)
cow
(Bos Taurus)
Mammalia METTL12 34 35
  • 83.54 (n)
dog
(Canis familiaris)
Mammalia METTL12 34 35
  • 81.39 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl12 34
  • 48.67 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:113305 34
  • 50.57 (n)
METTL12 35
  • 37 (a)
OneToOne
Species where no ortholog for METTL12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for METTL12 Gene

ENSEMBL:
Gene Tree for METTL12 (if available)
TreeFam:
Gene Tree for METTL12 (if available)

Paralogs for METTL12 Gene

No data available for Paralogs for METTL12 Gene

Variants for METTL12 Gene

Sequence variations from dbSNP and Humsavar for METTL12 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs111355410 -- 62,665,238(+) GCCCC(G/T)GCCTT intron-variant, upstream-variant-2KB
rs111399855 -- 62,666,261(+) GCCAT(C/G)ATTGT intron-variant, upstream-variant-2KB
rs111425217 -- 62,666,440(+) GGGAT(C/T)GGCTG intron-variant, upstream-variant-2KB, reference, missense
rs112138215 -- 62,666,900(+) CCCTC(A/G/T)GGGGA intron-variant, upstream-variant-2KB, reference, missense
rs112253711 -- 62,666,362(+) CGACA(C/T)AGACC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for METTL12 Gene

Variant ID Type Subtype PubMed ID
nsv555174 CNV gain 21841781
nsv832182 CNV gain+loss 17160897

Variation tolerance for METTL12 Gene

Residual Variation Intolerance Score: 85.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.54; 72.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for METTL12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
METTL12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL12 Gene

Disorders for METTL12 Gene

Relevant External Links for METTL12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
METTL12

No disorders were found for METTL12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL12 Gene

Publications for METTL12 Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Human METTL20 methylates lysine residues adjacent to the recognition loop of the electron transfer flavoprotein in mitochondria. (PMID: 25023281) Rhein V.F. … Walker J.E. (J. Biol. Chem. 2014) 4 64
  4. Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. (PMID: 16368877) Choy K.W. … Pang C.P. (Physiol. Genomics 2006) 3 64
  5. Mammalian small nucleolar RNAs are mobile genetic elements. (PMID: 17154719) Weber M.J. (PLoS Genet. 2006) 3 64

Products for METTL12 Gene

Sources for METTL12 Gene

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