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Aliases for METTL12 Gene

Aliases for METTL12 Gene

  • Methyltransferase Like 12 2 3
  • Putative Methyltransferase LOC751071, Mitochondrial 3
  • Methyltransferase-Like Protein 12, Mitochondrial 3
  • EC 2.1.1.- 4
  • U99HG 3

External Ids for METTL12 Gene

Previous GeneCards Identifiers for METTL12 Gene

  • GC11P062199
  • GC11P062201
  • GC11P062433
  • GC11P058761
  • GC11P062434
  • GC11P062436
  • GC11P062440

Summaries for METTL12 Gene

GeneCards Summary for METTL12 Gene

METTL12 (Methyltransferase Like 12) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity.

UniProtKB/Swiss-Prot for METTL12 Gene

  • Putative methyltransferase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL12 Gene

Genomics for METTL12 Gene

Regulatory Elements for METTL12 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for METTL12 Gene

Start:
62,665,234 bp from pter
End:
62,668,496 bp from pter
Size:
3,263 bases
Orientation:
Plus strand

Genomic View for METTL12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for METTL12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL12 Gene

Proteins for METTL12 Gene

  • Protein details for METTL12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MUP2-MET12_HUMAN
    Recommended name:
    Methyltransferase-like protein 12, mitochondrial
    Protein Accession:
    A8MUP2
    Secondary Accessions:
    • B7Z4C1

    Protein attributes for METTL12 Gene

    Size:
    240 amino acids
    Molecular mass:
    25910 Da
    Quaternary structure:
    No Data Available

neXtProt entry for METTL12 Gene

Proteomics data for METTL12 Gene at MOPED

Post-translational modifications for METTL12 Gene

No Post-translational modifications

Other Protein References for METTL12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for METTL12 Gene

Domains for METTL12 Gene

Protein Domains for METTL12 Gene

Suggested Antigen Peptide Sequences for METTL12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A8MUP2

UniProtKB/Swiss-Prot:

MET12_HUMAN :
  • A8MUP2
Family:
  • Belongs to the methyltransferase superfamily.
genes like me logo Genes that share domains with METTL12: view

No data available for Gene Families for METTL12 Gene

Function for METTL12 Gene

Molecular function for METTL12 Gene

UniProtKB/Swiss-Prot Function: Putative methyltransferase.

Enzyme Numbers (IUBMB) for METTL12 Gene

Gene Ontology (GO) - Molecular Function for METTL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with METTL12: view

Animal Model Products

CRISPR Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for METTL12 Gene

Localization for METTL12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL12 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for METTL12 Gene COMPARTMENTS Subcellular localization image for METTL12 gene
Compartment Confidence
mitochondrion 3
cytosol 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for METTL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with METTL12: view

Pathways for METTL12 Gene

SuperPathways for METTL12 Gene

No Data Available

Interacting Proteins for METTL12 Gene

Gene Ontology (GO) - Biological Process for METTL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL12: view

No data available for Pathways by source for METTL12 Gene

Transcripts for METTL12 Gene

mRNA/cDNA for METTL12 Gene

(5) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for METTL12 Gene

Methyltransferase like 12:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for METTL12

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for METTL12
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL12 Gene

No ASD Table

Relevant External Links for METTL12 Gene

GeneLoc Exon Structure for
METTL12
ECgene alternative splicing isoforms for
METTL12

Expression for METTL12 Gene

mRNA expression in normal human tissues for METTL12 Gene

SOURCE GeneReport for Unigene cluster for METTL12 Gene Hs.640726

genes like me logo Genes that share expressions with METTL12: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for METTL12 Gene

Orthologs for METTL12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for METTL12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL12 35
  • 99.17 (n)
  • 98.75 (a)
METTL12 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia METTL12 35
  • 83.54 (n)
  • 84.52 (a)
METTL12 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia METTL12 35
  • 81.39 (n)
  • 78.33 (a)
METTL12 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl12 35
  • 48.67 (n)
  • 41.5 (a)
zebrafish
(Danio rerio)
Actinopterygii METTL12 36
  • 37 (a)
OneToOne
zgc:113305 35
  • 50.57 (n)
  • 44.33 (a)
Species with no ortholog for METTL12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for METTL12 Gene

ENSEMBL:
Gene Tree for METTL12 (if available)
TreeFam:
Gene Tree for METTL12 (if available)

Paralogs for METTL12 Gene

No data available for Paralogs for METTL12 Gene

Variants for METTL12 Gene

Sequence variations from dbSNP and Humsavar for METTL12 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
VAR_046283 -

Structural Variations from Database of Genomic Variants (DGV) for METTL12 Gene

Variant ID Type Subtype PubMed ID
nsv832182 CNV Gain+Loss 17160897

Relevant External Links for METTL12 Gene

HapMap Linkage Disequilibrium report
METTL12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL12 Gene

Disorders for METTL12 Gene

No disorders were found for METTL12 Gene.

No data available for UniProtKB/Swiss-Prot for METTL12 Gene

Publications for METTL12 Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. (PMID: 16368877) Choy K.W. … Pang C.P. (Physiol. Genomics 2006) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Mammalian small nucleolar RNAs are mobile genetic elements. (PMID: 17154719) Weber M.J. (PLoS Genet. 2006) 3

Products for METTL12 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate METTL12
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for METTL12
    • Block miRNA regulation of METTL12 using miScript Target Protectors

    Sources for METTL12 Gene

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