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Aliases for METTL12 Gene

Aliases for METTL12 Gene

  • Methyltransferase Like 12 2 3 5
  • Putative Methyltransferase LOC751071, Mitochondrial 3
  • EC 2.1.1.- 4
  • U99HG 3

External Ids for METTL12 Gene

Previous GeneCards Identifiers for METTL12 Gene

  • GC11P062199
  • GC11P062201
  • GC11P062433
  • GC11P058761
  • GC11P062434
  • GC11P062436
  • GC11P062440

Summaries for METTL12 Gene

GeneCards Summary for METTL12 Gene

METTL12 (Methyltransferase Like 12) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity.

UniProtKB/Swiss-Prot for METTL12 Gene

  • Putative methyltransferase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL12 Gene

Genomics for METTL12 Gene

Regulatory Elements for METTL12 Gene

Promoters for METTL12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around METTL12 on UCSC Golden Path with GeneCards custom track

Genomic Location for METTL12 Gene

Chromosome:
11
Start:
62,665,263 bp from pter
End:
62,668,496 bp from pter
Size:
3,234 bases
Orientation:
Plus strand

Genomic View for METTL12 Gene

Genes around METTL12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL12 Gene

Proteins for METTL12 Gene

  • Protein details for METTL12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MUP2-MET12_HUMAN
    Recommended name:
    Methyltransferase-like protein 12, mitochondrial
    Protein Accession:
    A8MUP2
    Secondary Accessions:
    • B7Z4C1

    Protein attributes for METTL12 Gene

    Size:
    240 amino acids
    Molecular mass:
    25910 Da
    Quaternary structure:
    No Data Available

neXtProt entry for METTL12 Gene

Proteomics data for METTL12 Gene at MOPED

Post-translational modifications for METTL12 Gene

No Post-translational modifications

Other Protein References for METTL12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for METTL12 Gene

Domains & Families for METTL12 Gene

Gene Families for METTL12 Gene

Protein Domains for METTL12 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for METTL12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A8MUP2

UniProtKB/Swiss-Prot:

MET12_HUMAN :
  • Belongs to the methyltransferase superfamily.
Family:
  • Belongs to the methyltransferase superfamily.
genes like me logo Genes that share domains with METTL12: view

Function for METTL12 Gene

Molecular function for METTL12 Gene

UniProtKB/Swiss-Prot Function:
Putative methyltransferase.

Enzyme Numbers (IUBMB) for METTL12 Gene

Phenotypes for METTL12 Gene

GenomeRNAi human phenotypes for METTL12:
genes like me logo Genes that share phenotypes with METTL12: view

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL12 Gene

Localization for METTL12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL12 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for METTL12 Gene COMPARTMENTS Subcellular localization image for METTL12 gene
Compartment Confidence
mitochondrion 4
cytosol 3
nucleus 3
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for METTL12 Gene

Pathways & Interactions for METTL12 Gene

SuperPathways for METTL12 Gene

No Data Available

Interacting Proteins for METTL12 Gene

Gene Ontology (GO) - Biological Process for METTL12 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for METTL12 Gene

Drugs & Compounds for METTL12 Gene

No Compound Related Data Available

Transcripts for METTL12 Gene

mRNA/cDNA for METTL12 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for METTL12 Gene

Methyltransferase like 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for METTL12 Gene

No ASD Table

Relevant External Links for METTL12 Gene

GeneLoc Exon Structure for
METTL12
ECgene alternative splicing isoforms for
METTL12

Expression for METTL12 Gene

mRNA expression in normal human tissues for METTL12 Gene

SOURCE GeneReport for Unigene cluster for METTL12 Gene Hs.640726

genes like me logo Genes that share expression patterns with METTL12: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for METTL12 Gene

Orthologs for METTL12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for METTL12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia METTL12 35
  • 83.54 (n)
  • 84.52 (a)
METTL12 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia METTL12 35
  • 81.39 (n)
  • 78.33 (a)
METTL12 36
  • 51 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia METTL12 35
  • 99.17 (n)
  • 98.75 (a)
METTL12 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl12 35
  • 48.67 (n)
  • 41.5 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:113305 35
  • 50.57 (n)
  • 44.33 (a)
METTL12 36
  • 37 (a)
OneToOne
Species with no ortholog for METTL12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for METTL12 Gene

ENSEMBL:
Gene Tree for METTL12 (if available)
TreeFam:
Gene Tree for METTL12 (if available)

Paralogs for METTL12 Gene

No data available for Paralogs for METTL12 Gene

Variants for METTL12 Gene

Sequence variations from dbSNP and Humsavar for METTL12 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_046283 -

Structural Variations from Database of Genomic Variants (DGV) for METTL12 Gene

Variant ID Type Subtype PubMed ID
nsv832182 CNV Gain+Loss 17160897

Variation tolerance for METTL12 Gene

Residual Variation Intolerance Score: 85.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.54; 72.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for METTL12 Gene

HapMap Linkage Disequilibrium report
METTL12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL12 Gene

Disorders for METTL12 Gene

Relevant External Links for METTL12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
METTL12

No disorders were found for METTL12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL12 Gene

Publications for METTL12 Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 3 4 67
  2. Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. (PMID: 16368877) Choy K.W. … Pang C.P. (Physiol. Genomics 2006) 3
  3. Mammalian small nucleolar RNAs are mobile genetic elements. (PMID: 17154719) Weber M.J. (PLoS Genet. 2006) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for METTL12 Gene

Sources for METTL12 Gene

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