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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

METTL11B Gene

protein-coding GIFtS: 35
GCID: GC01P170115

methyltransferase like 11B

(Previous name: chromosome 1 open reading frame 184 )
(Previous symbol: C1orf184)

Explore 2 diseases affiliated with
METTL11B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Methyltransferase Like 11B¹ ²		X-Pro-Lys N-Terminal Protein Methyltransferase 1B² ³
C1orf184¹ ² ³		Chromosome 1 Open Reading Frame 184¹
HOMT1B¹ ²		Alpha N-Terminal Protein Methyltransferase 1B²
Methyltransferase-Like Protein 11B² ³		EC 2.1.1.244³
NTM1B² ³

External Ids:	HGNC: 31932¹	Entrez Gene: 149281²	Ensembl: ENSG00000203740⁷	UniProtKB: Q5VVY1³

Export aliases for METTL11B gene to outside databases

Previous GC identifers: GC01P168382 GC01P141338

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: NTM1B_HUMAN, Q5VVY1

Function: Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif

[Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of

exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in

the Pro-Pro-Lys motif (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the METTL11B gene promoter:
GCNF Pax-2 Pax-2a HNF-1A Gfi-1 MEF-2A GCNF-1 HNF-1 aMEF-2 Pax-4a
Other transcription factors

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL11B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24.2 Ensembl cytogenetic band: 1q24.2 HGNC cytogenetic band: 1q24.2

METTL11B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
METTL11B gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P170115: view genomic region (about GC identifiers)

Start:	170,115,142 bp from pter	End:	170,136,931 bp from pter
Size:	21,790 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
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About This Section

UniProtKB/Swiss-Prot: NTM1B_HUMAN, Q5VVY1 (See protein sequence)

Recommended Name: Alpha N-terminal protein methyltransferase 1B

Size: 283 amino acids; 32400 Da

Sequence caution: Sequence=CAH72139.1; Type=Erroneous gene model prediction;

Secondary accessions: B2RXI0

Explore the universe of human proteins at neXtProt for METTL11B: NX_Q5VVY1

METTL11B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001129579.1

ENSEMBL proteins:

ENSP00000408058

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

METTL11B for domains About GeneDecksing

1 InterPro domain/family:

IPR008576 DUF858_MeTrfase_lik

Graphical View of Domain Structure for InterPro Entry Q5VVY1

ProtoNet protein and cluster: Q5VVY1

UniProtKB/Swiss-Prot: NTM1B_HUMAN, Q5VVY1

Similarity: Belongs to the methyltransferase superfamily. NTM1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NTM1B_HUMAN, Q5VVY1

Function: Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif

[Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of

exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in

the Pro-Pro-Lys motif (By similarity)

Catalytic activity: 3 S-adenosyl-L-methionine + N-terminal-(A,S)PK-[protein] = 3 S-adenosyl-L-homocysteine +

N-terminal-N,N,N-trimethyl-N-(A,S)PK-[protein]

Catalytic activity: 2 S-adenosyl-L-methionine + N-terminal-PPK-[protein] = 2 S-adenosyl-L-homocysteine +

N-terminal-N,N-dimethyl-N-PPK-[protein]

Enzyme Number (IUBMB): EC 2.1.1.244¹

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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008168	methyltransferase activity	IEA	--

METTL11B for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for METTL11B:

Increased circadian period len

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for METTL11B

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for METTL11B gene:

NM_001136107.1

Unigene Cluster for METTL11B:

Methyltransferase like 11B

Hs.553612

Unigene Representative Sequence: BC171858

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000439373(uc009wvv.1) ENST00000367764

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Additional cDNA sequence:

BC157860.1 BC171858.1

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

METTL11B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACATCCTCC

About this image

METTL11B expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Maxillary Process

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See METTL11B Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.553612

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for METTL11B gene from 7/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	METTL11B¹	methyltransferase like 11B	76.05(n) 76.53(a)		429066 XM_426622.3 XP_426622.3
lizard (Anolis carolinensis)	Reptilia	METTL11B⁶	--	75(a)	1 ↔ 1	GL343300.1(1489838-1503641)
zebrafish (Danio rerio)	Actinopterygii	mettl11b¹	methyltransferase like 11B	63.77(n) 61.96(a)		568419 NM_001202453.1 NP_001189382.1
fruit fly (Drosophila melanogaster)	Insecta	Ntmt⁶	N-terminal methyltransferase	32(a)	1 → many	2R(5753137-5754189)
worm (Caenorhabditis elegans)	Secernentea	Y74C9A.3⁶	Alpha N-terminal protein methyltransferase 1	38(a)	1 → many	I(4119-10232)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G44450⁶	methyltransferase	24(a)	1 → many	5(17914023-17916019)
rice (Oryza sativa)	Liliopsida	--	ad-003, putative, expressed	23(a)	1 → many	3(32372797-32376692)

ENSEMBL Gene Tree for METTL11B (if available)
TreeFam Gene Tree for METTL11B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for METTL11B gene

NTMT1²

1 SIMAP similar gene for METTL11B using alignment to 1 protein entry: NTM1B_HUMAN:

NTMT1

METTL11B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147135432^1,2		--	170113191(+)	`TCACTG/TACACT`	1	--	us2k¹		0	--	--	--	--
rs78469049^1,2	C,	--	170113205(+)	`GTTAGT/AGGATT`	1	--	us2k¹		2		NA	122
rs185062265^1,2		--	170113324(+)	`AGTGAC/GAGAAA`	1	--	us2k¹		0	--	--	--	--
rs138689228^1,2		--	170113409(+)	`TTCAGC/TGGTGA`	1	--	us2k¹		0	--	--	--	--
rs144090361^1,2		--	170113634(+)	`GGGGAC/TAAGTG`	1	--	us2k¹		0	--	--	--	--
rs189338276^1,2		--	170113736(+)	`CCCTCA/CCTAGA`	1	--	us2k¹		0	--	--	--	--
rs80036320^1,2	C,	--	170113740(+)	`CACTAG/AACATG`	1	--	us2k¹		3		WA NA	240
rs144392172^1,2		--	170113754(+)	`TCTGCA/CAGCAC`	1	--	us2k¹		0	--	--	--	--
rs148761841^1,2		--	170113994(+)	`TTTTCA/CTGTTA`	1	--	us2k¹		0	--	--	--	--
rs150886360^1,2		--	170114030(+)	`GTCATG/TGTCCC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for METTL11B (170115142 - 170136931 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for METTL11B: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

METTL11B for disorders About GeneDecksing

2 diseases for METTL11B: About MalaCards

homocysteine neuronitis

Export disorders for METTL11B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for METTL11B gene integrated from 9 sources:
(articles sorted by number of sources associating them with METTL11B)

Utopia: connect your pdf to the dynamic
world of online information

The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 149281	HGNC: 31932	Ensembl:ENSG00000203740	euGenes: HUgn149281	ECgene: METTL11B
H-InvDB: METTL11B

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for METTL11B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for METTL11B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for METTL11B gene:
Search GeneIP for patents involving METTL11B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes METTL11B gene at Home site.

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METTL11B Gene

methyltransferase like 11B

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Export list of displayed genes

METTL11B Gene

methyltransferase like 11B

Aliasesfor METTL11B gene

Summariesfor METTL11B gene

Genomic Viewsfor METTL11B gene

Proteinsfor METTL11B gene

Protein Domains /Familiesfor METTL11B gene

Functionfor METTL11B gene

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for METTL11B gene

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for METTL11B gene

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for METTL11B gene

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for METTL11B gene

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