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METTL11B Gene

protein-coding   GIFtS: 36
GCID: GC01P170115

Methyltransferase Like 11B

(Previous name: chromosome 1 open reading frame 184)
(Previous symbol: C1orf184)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Methyltransferase Like 11B1 2     Chromosome 1 Open Reading Frame 1841
C1orf1841 2 3     HOMT1B2
Methyltransferase-Like Protein 11B2 3     Alpha N-Terminal Protein Methyltransferase 1B2
NTM1B2 3     EC 2.1.1.-3
X-Pro-Lys N-Terminal Protein Methyltransferase 1B2 3     NRMT23

External Ids:    HGNC: 319321   Entrez Gene: 1492812   Ensembl: ENSG000002037407   UniProtKB: Q5VVY13   

Export aliases for METTL11B gene to outside databases

Previous GC identifers: GC01P168382 GC01P141338


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for METTL11B Gene:
METTL11B (methyltransferase like 11B) is a protein-coding gene. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is NTMT1.

UniProtKB/Swiss-Prot: NTM1B_HUMAN, Q5VVY1
Function: Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal
motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed
alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May
activate NTMT1 by priming its substrates for trimethylation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the METTL11B gene promoter:
         GCNF   Pax-2   Pax-2a   HNF-1A   Gfi-1   MEF-2A   GCNF-1   HNF-1   aMEF-2   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for METTL11B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat METTL11B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24.2   Ensembl cytogenetic band:  1q24.2   HGNC cytogenetic band: 1q24.2

METTL11B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
METTL11B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P170115:  view genomic region     (about GC identifiers)

Start:
170,115,142 bp from pter      End:
170,136,931 bp from pter
Size:
21,790 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NTM1B_HUMAN, Q5VVY1 (See protein sequence)
Recommended Name: Alpha N-terminal protein methyltransferase 1B  
Size: 283 amino acids; 32400 Da
Sequence caution: Sequence=CAH72139.1; Type=Erroneous gene model prediction;
Secondary accessions: B2RXI0

Explore the universe of human proteins at neXtProt for METTL11B: NX_Q5VVY1

Explore proteomics data for METTL11B at MOPED


See METTL11B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001129579.1  
ENSEMBL proteins: 
 ENSP00000408058  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR008576 DUF858_MeTrfase_lik

Graphical View of Domain Structure for InterPro Entry Q5VVY1

ProtoNet protein and cluster: Q5VVY1

UniProtKB/Swiss-Prot: NTM1B_HUMAN, Q5VVY1
Similarity: Belongs to the methyltransferase superfamily. NTM1 family


Find genes that share domains with METTL11B           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: NTM1B_HUMAN, Q5VVY1
Function: Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal
motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed
alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May
activate NTMT1 by priming its substrates for trimethylation
Catalytic activity: S-adenosyl-L-methionine + N-terminal-(A,S)PK-[protein] = S-adenosyl-L-homocysteine +
N-terminal-N-monomethyl-N-(A,S)PK-[protein]
Catalytic activity: S-adenosyl-L-methionine + N-terminal-PPK-[protein] = S-adenosyl-L-homocysteine +
N-terminal-N-monomethyl-N-PPK-[protein]

     Enzyme Number (IUBMB): EC 2.1.1.-1

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008168methyltransferase activity IEA--
     
Find genes that share ontologies with METTL11B           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for METTL11B:
 Increased circadian period len 

Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
NTM1B_HUMAN, Q5VVY1: Nucleus
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion2
cytosol1
nucleus1
peroxisome1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

Find genes that share ontologies with METTL11B           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for METTL11B
Interactions:

    Search GeneGlobe Interaction Network for METTL11B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for METTL11B (ENSP000004080584) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
InteractantInteraction Details
GeneCardExternal ID(s)
DNAJC2ENSP000003685654STRING: ENSP00000368565
PSAT1ENSP000003657734STRING: ENSP00000365773
MRPL2ENSP000003734044STRING: ENSP00000373404
RBM34ENSP000003555654STRING: ENSP00000355565
PAOXENSP000002780604STRING: ENSP00000278060
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008152metabolic process ----

Find genes that share ontologies with METTL11B           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for METTL11B (NTM1B)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for METTL11B gene: 
NM_001136107.1  

Unigene Cluster for METTL11B:

Methyltransferase like 11B
Hs.553612
Unigene Representative Sequence: BC171858
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000439373(uc009wvv.1) ENST00000367764
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Additional mRNA sequence: 

BC157860.1 BC171858.1 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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METTL11B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GACATCCTCC
METTL11B Expression
About this image

METTL11B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

METTL11B Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.553612
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for METTL11B gene from Selected species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Mettl11b1 , 5 methyltransferase like 11B1, 5 90.46(n)1
93.64(a)1
  1 (71.00 cM)5
2408791  NM_001143956.11  NP_001137428.11 
 1637022575 
chicken
(Gallus gallus)
Aves METTL11B1 methyltransferase like 11B 76.02(n)
76.26(a)
  429066  XM_426622.4  XP_426622.3 
lizard
(Anolis carolinensis)
Reptilia METTL11B6
methyltransferase like 11B
72(a)
1 ↔ 1
GL343300.1(1489664-1504430)
tropical clawed frog
(Xenopus tropicalis)
Amphibia mettl11b1 methyltransferase like 11B 70.5(n)
73.38(a)
  100485318  XM_002933785.2  XP_002933831.1 
zebrafish
(Danio rerio)
Actinopterygii mettl11b1 methyltransferase like 11B 63.77(n)
61.96(a)
  568419  NM_001202453.1  NP_001189382.1 
fruit fly
(Drosophila melanogaster)
Insecta Ntmt6
N-terminal methyltransferase
28(a)
1 → many
2R(5753137-5754189)
worm
(Caenorhabditis elegans)
Secernentea homt-16
Protein HOMT-1 (homt-1) mRNA, complete cds
38(a)
1 → many
I(4119-10230) WBGene00022277
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAE16
AdoMet-dependent proline methyltransferase; cataly...
33(a)
1 → many
II(734832-735530) YBR261C


ENSEMBL Gene Tree for METTL11B (if available)
TreeFam Gene Tree for METTL11B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for METTL11B gene
NTMT12  
1 SIMAP similar gene for METTL11B using alignment to 1 protein entry:     NTM1B_HUMAN:
NTMT1

Find genes that share paralogs with METTL11B           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for METTL11B (see all 387)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1471354321,2
--170113191(+) TCACTG/TACACT 1 -- us2k10--------
rs784690491,2
C,F--170113205(+) GTTAGT/AGGATT 1 -- us2k12Minor allele frequency- A:0.05NA 122
rs1850622651,2
--170113324(+) AGTGAC/GAGAAA 1 -- us2k10--------
rs1386892281,2
--170113409(+) TTCAGC/TGGTGA 1 -- us2k10--------
rs1440903611,2
C--170113634(+) GGGGAC/TAAGTG 1 -- us2k10--------
rs1893382761,2
--170113736(+) CCCTCA/CCTAGA 1 -- us2k10--------
rs800363201,2
C--170113740(+) CACTAG/AACATG 1 -- us2k13Minor allele frequency- A:0.05WA NA 240
rs1443921721,2
--170113754(+) TCTGCA/CAGCAC 1 -- us2k10--------
rs1487618411,2
--170113994(+) TTTTCA/CTGTTA 1 -- us2k10--------
rs1508863601,2
--170114030(+) GTCATG/TGTCCC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for METTL11B (170115142 - 170136931 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for METTL11B:    About this table    
Variant IDTypeSubtypePubMed ID
nsv3454CNV Loss18451855

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing METTL11B
DNA2.0 Custom Variant and Variant Library Synthesis for METTL11B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for METTL11B gene integrated from 10 sources:
(articles sorted by number of sources associating them with METTL11B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
  2. NRMT2 is an N-terminal monomethylase that primes for its homologue NRMT1. (PubMed id 24090352)2 Petkowski J.J.... Schaner Tooley C.E. (Biochem. J. 2013)
  3. Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects. (PubMed id 19901119)1 TreviA+o L.R....Relling M.V. (J. Clin. Oncol. 2009)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 149281 HGNC: 31932 Ensembl:ENSG00000203740 euGenes: HUgn149281 ECgene: METTL11B
H-InvDB: METTL11B

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for METTL11B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for METTL11B gene:
Search GeneIP for patents involving METTL11B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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