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Aliases for METTL11B Gene

Aliases for METTL11B Gene

  • Methyltransferase Like 11B 2 3 5
  • X-Pro-Lys N-Terminal Protein Methyltransferase 1B 3 4
  • Methyltransferase-Like Protein 11B 3 4
  • C1orf184 3 4
  • NTM1B 3 4
  • Chromosome 1 Open Reading Frame 184 2
  • EC 2.1.1.299 4
  • HOMT1B 3
  • NRMT2 4

External Ids for METTL11B Gene

Previous HGNC Symbols for METTL11B Gene

  • C1orf184

Previous GeneCards Identifiers for METTL11B Gene

  • GC01P168382
  • GC01P141338

Summaries for METTL11B Gene

GeneCards Summary for METTL11B Gene

METTL11B (Methyltransferase Like 11B) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity and N-terminal protein N-methyltransferase activity. An important paralog of this gene is NTMT1.

UniProtKB/Swiss-Prot for METTL11B Gene

  • Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL11B Gene

Genomics for METTL11B Gene

Regulatory Elements for METTL11B Gene

Enhancers for METTL11B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around METTL11B on UCSC Golden Path with GeneCards custom track

Genomic Location for METTL11B Gene

Chromosome:
1
Start:
170,146,001 bp from pter
End:
170,168,923 bp from pter
Size:
22,923 bases
Orientation:
Plus strand

Genomic View for METTL11B Gene

Genes around METTL11B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL11B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL11B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL11B Gene

Proteins for METTL11B Gene

  • Protein details for METTL11B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VVY1-NTM1B_HUMAN
    Recommended name:
    Alpha N-terminal protein methyltransferase 1B
    Protein Accession:
    Q5VVY1
    Secondary Accessions:
    • B2RXI0

    Protein attributes for METTL11B Gene

    Size:
    283 amino acids
    Molecular mass:
    32400 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAH72139.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for METTL11B Gene

Proteomics data for METTL11B Gene at MOPED

Post-translational modifications for METTL11B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for METTL11B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for METTL11B Gene

Domains & Families for METTL11B Gene

Gene Families for METTL11B Gene

Protein Domains for METTL11B Gene

Suggested Antigen Peptide Sequences for METTL11B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VVY1

UniProtKB/Swiss-Prot:

NTM1B_HUMAN :
  • Belongs to the methyltransferase superfamily. NTM1 family.
Family:
  • Belongs to the methyltransferase superfamily. NTM1 family.
genes like me logo Genes that share domains with METTL11B: view

Function for METTL11B Gene

Molecular function for METTL11B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + N-terminal-(A,P,S)PK-[protein] = S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-(A,P,S)PK-[protein].
UniProtKB/Swiss-Prot Function:
Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation.

Enzyme Numbers (IUBMB) for METTL11B Gene

Gene Ontology (GO) - Molecular Function for METTL11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071885 N-terminal protein N-methyltransferase activity IBA --
genes like me logo Genes that share ontologies with METTL11B: view

Phenotypes for METTL11B Gene

GenomeRNAi human phenotypes for METTL11B:
genes like me logo Genes that share phenotypes with METTL11B: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for METTL11B Gene

Localization for METTL11B Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL11B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for METTL11B Gene COMPARTMENTS Subcellular localization image for METTL11B gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for METTL11B Gene

Pathways & Interactions for METTL11B Gene

SuperPathways for METTL11B Gene

No Data Available

Interacting Proteins for METTL11B Gene

Gene Ontology (GO) - Biological Process for METTL11B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for METTL11B Gene

Drugs & Compounds for METTL11B Gene

(2) Drugs for METTL11B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma 0
genes like me logo Genes that share compounds with METTL11B: view

Transcripts for METTL11B Gene

mRNA/cDNA for METTL11B Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for METTL11B Gene

Methyltransferase like 11B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for METTL11B Gene

No ASD Table

Relevant External Links for METTL11B Gene

GeneLoc Exon Structure for
METTL11B
ECgene alternative splicing isoforms for
METTL11B

Expression for METTL11B Gene

mRNA expression in normal human tissues for METTL11B Gene

mRNA differential expression in normal tissues according to GTEx for METTL11B Gene

This gene is overexpressed in Heart - Left Ventricle (x22.0) and Heart - Atrial Appendage (x19.0).

Protein differential expression in normal tissues from HIPED for METTL11B Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for METTL11B Gene



SOURCE GeneReport for Unigene cluster for METTL11B Gene Hs.553612

genes like me logo Genes that share expression patterns with METTL11B: view

Protein tissue co-expression partners for METTL11B Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for METTL11B Gene

Orthologs for METTL11B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for METTL11B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia METTL11B 35
  • 90.69 (n)
  • 94.35 (a)
METTL11B 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia METTL11B 35
  • 92.93 (n)
  • 95.41 (a)
METTL11B 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mettl11b 35
  • 90.46 (n)
  • 93.64 (a)
Mettl11b 16
Mettl11b 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia METTL11B 35
  • 99.65 (n)
  • 98.94 (a)
METTL11B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mettl11b 35
  • 90.46 (n)
  • 93.29 (a)
oppossum
(Monodelphis domestica)
Mammalia METTL11B 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia METTL11B 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves METTL11B 35
  • 76.02 (n)
  • 76.26 (a)
METTL11B 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia METTL11B 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl11b 35
  • 70.5 (n)
  • 73.38 (a)
zebrafish
(Danio rerio)
Actinopterygii mettl11b 35
  • 63.77 (n)
  • 61.96 (a)
mettl11b 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ntmt 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea homt-1 36
  • 38 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAE1 36
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToMany
Species with no ortholog for METTL11B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL11B Gene

ENSEMBL:
Gene Tree for METTL11B (if available)
TreeFam:
Gene Tree for METTL11B (if available)

Paralogs for METTL11B Gene

Paralogs for METTL11B Gene

(1) SIMAP similar genes for METTL11B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with METTL11B: view

Variants for METTL11B Gene

Sequence variations from dbSNP and Humsavar for METTL11B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs6427235 - 170,166,619(+) TGGAA(C/T)CCTTT reference, missense
rs12073565 - 170,160,578(+) CAGAG(C/G)TAAAC reference, missense
rs12735494 - 170,167,644(+) TCCGG(A/C)GCCTA reference, missense
rs477960 -- 170,169,359(-) CTGCT(A/G)ATTTG downstream-variant-500B
rs480667 -- 170,169,074(-) GAAAT(G/T)AGAGC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for METTL11B Gene

Variant ID Type Subtype PubMed ID
nsv3454 CNV Loss 18451855

Variation tolerance for METTL11B Gene

Gene Damage Index Score: 9.01; 87.44% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for METTL11B Gene

Disorders for METTL11B Gene

Relevant External Links for METTL11B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
METTL11B

No disorders were found for METTL11B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL11B Gene

Publications for METTL11B Gene

  1. NRMT2 is an N-terminal monomethylase that primes for its homologue NRMT1. (PMID: 24090352) Petkowski J.J. … Schaner Tooley C.E. (Biochem. J. 2013) 3 4 67
  2. Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects. (PMID: 19901119) TreviA+o L.R. … Relling M.V. (J. Clin. Oncol. 2009) 3
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for METTL11B Gene

Sources for METTL11B Gene

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