METTL10 Gene
protein-coding GIFtS: 46
GCID: GC10M126437
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methyltransferase like 10(Previous name: chromosome 10 open reading frame 138 )
(Previous symbol: C10orf138)
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Aliases
for METTL10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Methyltransferase Like 101 2 | | Methyltransferase-Like Protein 102 | | C10orf1381 2 3 | | EC 2.1.1.-3 | | Em:AC068896.31 2 | | EC 2.1.18 | | Chromosome 10 Open Reading Frame 1381 | | |
Export aliases for METTL10 gene to outside databasesPrevious GC identifer: GC10M120134 |
Summaries
for METTL10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for METTL10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the METTL10 gene promoter:
E2F-4 E2F-3a E2F-5 E2F-2 E2F E2F-1 POU2F1 FOXO4 POU2F1a Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for METTL10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q26.13 Ensembl cytogenetic band: 10q26.13 HGNC cytogenetic band: 10q26.13METTL10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M126437: view genomic region
(about GC identifiers)
Start:
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126,436,721 bp from pter |
End:
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126,480,446 bp from pter |
Size:
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43,726 bases |
Orientation:
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minus strand |
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Proteins
for METTL10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MET10_HUMAN, Q5JPI9 (See
protein sequence)Recommended Name: Methyltransferase-like protein 10 Size: 291 amino acids; 31830 Da
Secondary accessions: A8MPY7Explore the universe of human proteins at neXtProt for METTL10: NX_Q5JPI9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5JPI9
4/11 DME Specific Peptides for METTL10 (Q5JPI9) (see all 11)
METTL10 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_997719.2
ENSEMBL proteins: ENSP00000451190 ENSP00000357829 ENSP00000450447 ENSP00000450466
Human Recombinant Protein Products:
METTL10 Antibody Products:
Assay Products for METTL10: |
Protein
Domains /
Families
for METTL10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
METTL10 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5JPI9ProtoNet protein and cluster: Q5JPI9 UniProtKB/Swiss-Prot: MET10_HUMAN, Q5JPI9Similarity: Belongs to the methyltransferase superfamily |
Function
for METTL10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Enzyme Numbers (IUBMB): EC 2.1.1.-1 EC 2.1.12
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL10 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL10
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: METTL10 (NM_212554) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for METTL10 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL10 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL10 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008168 | methyltransferase activity |
IEA | -- |
METTL10 for ontologies About GeneDecksing
|
Pathways & Interactions
for METTL10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for METTL10
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5/7 Interacting proteins for METTL10 (Q5JPI93 ENSP000003578294) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
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Drugs & Compounds
for METTL10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for METTL10
Search CenterWatch for drugs/clinical trials and news about METTL10 / MET10
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Transcripts
for METTL10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for METTL10 gene: NM_212554.2 Unigene Cluster for METTL10: Methyltransferase like 10 Hs.741365 [show with all ESTs]Unigene Representative Sequence: AK0223547 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000495711 ENST00000466270(uc001lhy.1 uc001lhz.1 uc001lia.1)
ENST00000368836 ENST00000464099 ENST00000498770 ENST00000468738 ENST00000483542
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL10 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL10
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: METTL10 (NM_212554) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for METTL10 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL10 |
Additional cDNA sequence: AF318345.1 AK022354.1 AL832292.1 BC026167.1 7 DOTS entries: DT.306918 DT.100019969 DT.99991942 DT.121240940 DT.95168472 DT.102843200 DT.86852786 24/374 AceView cDNA sequences (see all 374): BC026167 BX478470 CA419633 AA443211 AA327591 AI027234 CF136269 BM974746 AI248479 AI084070 CA450138 AA234156 AI138698 AU122020 CK819523 AW473438 AA233909 BM753280 BQ063500 BU754493 CA417961 AW963597 BU727469 AA768001
GeneLoc Exon Structure
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Expression
for METTL10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| METTL10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTCTTGAT
About this image
See METTL10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for METTL10
SOURCE GeneReport for Unigene cluster: Hs.741365
SABiosciences Custom PCR Arrays for METTL10
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for METTL10
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat METTL10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL10 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL10 |
Orthologs
for METTL10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for METTL10 gene from 9/26 species (see all 26) About this table
ENSEMBL Gene Tree for METTL10 (if available)
TreeFam Gene Tree for METTL10 (if available) |
Paralogs
for METTL10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for METTL10 gene
- ENSG000002585392
3 SIMAP similar genes for METTL10 using alignment to 4 protein entries: MET10_HUMAN (see all proteins):pp14737 KIAA1651 OK/SW-cl.41
METTL10 for paralogs About GeneDecksing
|
Genomic Variants
for METTL10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for METTL10 (126436721 - 126480446 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for METTL10
1 CNV: 4715 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing METTL10 |
|
Disorders
/ Diseases
for METTL10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
METTL10 for disorders About GeneDecksing
2  diseases for METTL10: About MalaCardsalzheimer's disease malaria
Human Genome Epidemiology (HuGE) Navigator: METTL10 (1 document)
Export disorders for METTL10 gene to outside databases
|
Publications
for METTL10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for METTL10 gene integrated from 9 sources:
(articles sorted by number of sources associating them with METTL10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for METTL10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing METTL10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing METTL10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing METTL10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for METTL10 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for METTL10 gene:
Search GeneIP for patents involving METTL10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for METTL10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for METTL10 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for METTL10 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for METTL10 | | | OriGene Protein Over-expression Lysate for METTL10 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for METTL10 | | OriGene 3'-UTR Clone for METTL10 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METTL10 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METTL10 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for METTL10 | | OriGene Custom Protein Services for METTL10 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat METTL10 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing METTL10 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METTL10 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat METTL10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METTL10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METTL10 |
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 |  |  |  | |
| | | | Search Tocris compounds for METTL10 |
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 | | | METTL10 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL10 |
|  |  |  | | | | Search ThermoFisher Antibodies for METTL10 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL10 |
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