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Aliases for METTL10 Gene

Aliases for METTL10 Gene

  • Methyltransferase Like 10 2 3
  • Methyltransferase-Like Protein 10 3 4
  • C10orf138 3 4
  • Chromosome 10 Open Reading Frame 138 2
  • EC 2.1.1.- 4
  • EC 2.1.1 63

External Ids for METTL10 Gene

Previous HGNC Symbols for METTL10 Gene

  • C10orf138

Previous GeneCards Identifiers for METTL10 Gene

  • GC10M126437
  • GC10M120134

Summaries for METTL10 Gene

GeneCards Summary for METTL10 Gene

METTL10 (Methyltransferase Like 10) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity and tRNA (guanine-N7-)-methyltransferase activity. An important paralog of this gene is ENSG00000258539.

UniProtKB/Swiss-Prot for METTL10 Gene

  • S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL10 Gene

Genomics for METTL10 Gene

Regulatory Elements for METTL10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for METTL10 Gene

Chromosome:
10
Start:
124,748,149 bp from pter
End:
124,791,941 bp from pter
Size:
43,793 bases
Orientation:
Minus strand

Genomic View for METTL10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for METTL10 Gene

Proteins for METTL10 Gene

  • Protein details for METTL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JPI9-MET10_HUMAN
    Recommended name:
    Protein-lysine N-methyltransferase METTL10
    Protein Accession:
    Q5JPI9
    Secondary Accessions:
    • A8MPY7

    Protein attributes for METTL10 Gene

    Size:
    291 amino acids
    Molecular mass:
    31830 Da
    Quaternary structure:
    No Data Available

neXtProt entry for METTL10 Gene

Proteomics data for METTL10 Gene at MOPED

Post-translational modifications for METTL10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for METTL10 Gene

Domains & Families for METTL10 Gene

Gene Families for METTL10 Gene

Protein Domains for METTL10 Gene

Suggested Antigen Peptide Sequences for METTL10 Gene

Graphical View of Domain Structure for InterPro Entry

Q5JPI9

UniProtKB/Swiss-Prot:

MET10_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.
genes like me logo Genes that share domains with METTL10: view

Function for METTL10 Gene

Molecular function for METTL10 Gene

UniProtKB/Swiss-Prot Function:
S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.

Enzyme Numbers (IUBMB) for METTL10 Gene

Gene Ontology (GO) - Molecular Function for METTL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with METTL10: view

Phenotypes for METTL10 Gene

genes like me logo Genes that share phenotypes with METTL10: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for METTL10

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for METTL10 Gene

Localization for METTL10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL10 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for METTL10 Gene COMPARTMENTS Subcellular localization image for METTL10 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for METTL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with METTL10: view

Pathways & Interactions for METTL10 Gene

SuperPathways for METTL10 Gene

No Data Available

Interacting Proteins for METTL10 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357829%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000217182%0d%0a9606.ENSP00000330054%0d%0a
Selected Interacting proteins: Q5JPI9-MET10_HUMAN ENSP00000357829 for METTL10 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for METTL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL10: view

No data available for Pathways by source and SIGNOR curated interactions for METTL10 Gene

Drugs & Compounds for METTL10 Gene

No Compound Related Data Available

Transcripts for METTL10 Gene

Unigene Clusters for METTL10 Gene

Methyltransferase like 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for METTL10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL10 Gene

No ASD Table

Relevant External Links for METTL10 Gene

GeneLoc Exon Structure for
METTL10
ECgene alternative splicing isoforms for
METTL10

Expression for METTL10 Gene

mRNA expression in normal human tissues for METTL10 Gene

Protein differential expression in normal tissues from HIPED for METTL10 Gene

This gene is overexpressed in Heart (56.6) and Lung (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for METTL10 Gene



SOURCE GeneReport for Unigene cluster for METTL10 Gene Hs.741365

genes like me logo Genes that share expression patterns with METTL10: view

Protein tissue co-expression partners for METTL10 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for METTL10 Gene

Orthologs for METTL10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METTL10 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Mettl10 35
  • 88.89 (n)
  • 86.46 (a)
Mettl10 16
chimpanzee
(Pan troglodytes)
Mammalia METTL10 35
  • 99.77 (n)
  • 99.31 (a)
METTL10 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mettl10 35
  • 89.58 (n)
  • 84.37 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
OneToMany
chicken
(Gallus gallus)
Aves METTL10 35
  • 75.89 (n)
  • 76.6 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 67 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498530 35
  • 62.27 (n)
  • 64.29 (a)
zebrafish
(Danio rerio)
Actinopterygii mettl10 35
  • 62.19 (n)
  • 61.83 (a)
mettl10 36
  • 51 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005673 35
  • 53.14 (n)
  • 46.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9643 35
  • 52.57 (n)
  • 48.57 (a)
CG9643 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F29B9.1 35
  • 49.25 (n)
  • 38.76 (a)
F29B9.1 36
  • 31 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C07931g 35
  • 49.9 (n)
  • 38.6 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEE1 35
  • 50.29 (n)
  • 40.94 (a)
SEE1 36
  • 28 (a)
OneToMany
SEE1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AR401 35
  • 52.54 (n)
  • 44.02 (a)
rice
(Oryza sativa)
Liliopsida Os01g0121100 35
  • 53.85 (n)
  • 39.01 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC839.14c 35
  • 50 (n)
  • 44.25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for METTL10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL10 Gene

ENSEMBL:
Gene Tree for METTL10 (if available)
TreeFam:
Gene Tree for METTL10 (if available)

Paralogs for METTL10 Gene

Paralogs for METTL10 Gene

(3) SIMAP similar genes for METTL10 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with METTL10: view

Variants for METTL10 Gene

Sequence variations from dbSNP and Humsavar for METTL10 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs965484 -- 124,764,912(+) TCTCT(C/T)TTTTT intron-variant
rs1055256 -- 124,758,023(-) GTGCG(C/T)GTGCA utr-variant-3-prime
rs1055257 -- 124,757,960(-) CAAAG(A/T)TTTCA utr-variant-3-prime
rs1142693 -- 124,773,392(-) tagcc(A/G)ggtgt intron-variant
rs1142694 -- 124,773,346(-) cctgg(A/G)caaca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for METTL10 Gene

Variant ID Type Subtype PubMed ID
nsv832013 CNV Loss 17160897
nsv832014 CNV Loss 17160897
nsv825604 CNV Gain 20364138

Variation tolerance for METTL10 Gene

Residual Variation Intolerance Score: 76.19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.75; 57.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for METTL10 Gene

HapMap Linkage Disequilibrium report
METTL10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL10 Gene

Disorders for METTL10 Gene

Relevant External Links for METTL10

Genetic Association Database (GAD)
METTL10
Human Genome Epidemiology (HuGE) Navigator
METTL10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
METTL10
genes like me logo Genes that share disorders with METTL10: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL10 Gene

Publications for METTL10 Gene

  1. Selenium-based S-adenosylmethionine analog reveals the mammalian seven-beta-strand methyltransferase METTL10 to be an EF1A1 lysine methyltransferase. (PMID: 25144183) Shimazu T. … Shinkai Y. (PLoS ONE 2014) 2 67
  2. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 67
  3. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 67
  4. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S. … Mohammed S. (Anal. Chem. 2009) 67
  5. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 67

Products for METTL10 Gene

Sources for METTL10 Gene

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