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Aliases for METTL10 Gene

Aliases for METTL10 Gene

  • Methyltransferase Like 10 2 3 5
  • Methyltransferase-Like Protein 10 3 4
  • C10orf138 3 4
  • Protein-Lysine N-Methyltransferase METTL10 3
  • Chromosome 10 Open Reading Frame 138 2
  • EC 2.1.1.- 4
  • EC 2.1.1 61

External Ids for METTL10 Gene

Previous HGNC Symbols for METTL10 Gene

  • C10orf138

Previous GeneCards Identifiers for METTL10 Gene

  • GC10M126437
  • GC10M120134

Summaries for METTL10 Gene

GeneCards Summary for METTL10 Gene

METTL10 (Methyltransferase Like 10) is a Protein Coding gene. Among its related pathways are Metabolism of proteins. GO annotations related to this gene include methyltransferase activity and tRNA (guanine-N7-)-methyltransferase activity. An important paralog of this gene is ENSG00000258539.

UniProtKB/Swiss-Prot for METTL10 Gene

  • S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL10 Gene

Genomics for METTL10 Gene

Regulatory Elements for METTL10 Gene

Enhancers for METTL10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F124731 1.5 FANTOM5 ENCODE 66.6 +51.5 51508 18.4 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 GLIS2 ELK1 ZNF143 METTL10 ENSG00000234134 FAM53B FAM175B GC10P124736
GH10F124714 1.2 FANTOM5 ENCODE 46.4 +69.1 69144 16.1 HDGF PKNOX1 ARNT MLX WRNIP1 ZNF143 ZNF207 FOS KLF13 SP5 METTL10 FAM53B FAM175B ZRANB1 GC10P124712 GC10P124736
GH10F124790 1 ENCODE 38.1 +0.1 68 2.6 CREB3L1 MLX ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 FOS ZNF263 METTL10 EDRF1-AS1 ENSG00000258539
GH10F124756 1.1 FANTOM5 31.8 +34.8 34797 0.4 ZFHX2 SMARCA4 EGR2 METTL10 ZRANB1 GC10P124767 FAM53B
GH10F124691 1.4 FANTOM5 Ensembl ENCODE 30.2 +90.3 90347 20.0 HDGF ARNT WRNIP1 ARID4B SIN3A ZNF2 FOS ZNF263 TBX21 KAT8 METTL10 FAM53B LHPP ZRANB1 FAM53B-AS1 GC10M124645 PIR48648
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around METTL10 on UCSC Golden Path with GeneCards custom track

Promoters for METTL10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000363526 240 2600 CREB3L1 MLX ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 FOS ZNF263

Genomic Location for METTL10 Gene

Chromosome:
10
Start:
124,748,149 bp from pter
End:
124,791,941 bp from pter
Size:
43,793 bases
Orientation:
Minus strand

Genomic View for METTL10 Gene

Genes around METTL10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL10 Gene

Proteins for METTL10 Gene

  • Protein details for METTL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JPI9-MET10_HUMAN
    Recommended name:
    Protein-lysine N-methyltransferase METTL10
    Protein Accession:
    Q5JPI9
    Secondary Accessions:
    • A8MPY7

    Protein attributes for METTL10 Gene

    Size:
    291 amino acids
    Molecular mass:
    31830 Da
    Quaternary structure:
    No Data Available

neXtProt entry for METTL10 Gene

Post-translational modifications for METTL10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for METTL10 Gene

Domains & Families for METTL10 Gene

Gene Families for METTL10 Gene

Protein Domains for METTL10 Gene

Suggested Antigen Peptide Sequences for METTL10 Gene

Graphical View of Domain Structure for InterPro Entry

Q5JPI9

UniProtKB/Swiss-Prot:

MET10_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.
genes like me logo Genes that share domains with METTL10: view

Function for METTL10 Gene

Molecular function for METTL10 Gene

UniProtKB/Swiss-Prot Function:
S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.

Enzyme Numbers (IUBMB) for METTL10 Gene

Gene Ontology (GO) - Molecular Function for METTL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0016279 protein-lysine N-methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with METTL10: view
genes like me logo Genes that share phenotypes with METTL10: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL10 Gene

Localization for METTL10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL10 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for METTL10 Gene COMPARTMENTS Subcellular localization image for METTL10 gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for METTL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with METTL10: view

Pathways & Interactions for METTL10 Gene

genes like me logo Genes that share pathways with METTL10: view

Pathways by source for METTL10 Gene

Interacting Proteins for METTL10 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357829%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000330054%0d%0a9606.ENSP00000217182%0d%0a
Selected Interacting proteins: ENSP00000357829 Q5JPI9-MET10_HUMAN for METTL10 Gene via STRING IID

Gene Ontology (GO) - Biological Process for METTL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018022 peptidyl-lysine methylation IEA --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with METTL10: view

No data available for SIGNOR curated interactions for METTL10 Gene

Transcripts for METTL10 Gene

Unigene Clusters for METTL10 Gene

Methyltransferase like 10:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL10 Gene

No ASD Table

Relevant External Links for METTL10 Gene

GeneLoc Exon Structure for
METTL10
ECgene alternative splicing isoforms for
METTL10

Expression for METTL10 Gene

mRNA expression in normal human tissues for METTL10 Gene

Protein differential expression in normal tissues from HIPED for METTL10 Gene

This gene is overexpressed in Heart (56.6) and Lung (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for METTL10 Gene



Protein tissue co-expression partners for METTL10 Gene

NURSA nuclear receptor signaling pathways regulating expression of METTL10 Gene:

METTL10

SOURCE GeneReport for Unigene cluster for METTL10 Gene:

Hs.741365
genes like me logo Genes that share expression patterns with METTL10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for METTL10 Gene

Orthologs for METTL10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METTL10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL10 34 35
  • 99.77 (n)
rat
(Rattus norvegicus)
Mammalia Mettl10 34
  • 89.58 (n)
mouse
(Mus musculus)
Mammalia Mettl10 34 16
  • 88.89 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 68 (a)
OneToMany
chicken
(Gallus gallus)
Aves METTL10 34
  • 75.89 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 67 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498530 34
  • 62.27 (n)
zebrafish
(Danio rerio)
Actinopterygii mettl10 34 35
  • 62.19 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005673 34
  • 53.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9643 34 35
  • 52.57 (n)
worm
(Caenorhabditis elegans)
Secernentea F29B9.1 34 35
  • 49.25 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEE1 34 35
  • 50.29 (n)
EFM4 37
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C07931g 34
  • 49.9 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AR401 34
  • 52.54 (n)
rice
(Oryza sativa)
Liliopsida Os01g0121100 34
  • 53.85 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC839.14c 34
  • 50 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToMany
Species where no ortholog for METTL10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL10 Gene

ENSEMBL:
Gene Tree for METTL10 (if available)
TreeFam:
Gene Tree for METTL10 (if available)

Paralogs for METTL10 Gene

Paralogs for METTL10 Gene

(3) SIMAP similar genes for METTL10 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with METTL10: view

Variants for METTL10 Gene

Sequence variations from dbSNP and Humsavar for METTL10 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs10159947 -- 124,764,320(+) AAAAA(A/C)AAACT intron-variant
rs10430739 -- 124,768,683(+) aggcc(A/G)aggtt intron-variant
rs10430743 -- 124,768,428(+) acatg(G/T)tgaaa intron-variant
rs1055256 -- 124,758,023(-) GTGCG(C/T)GTGCA utr-variant-3-prime
rs1055257 -- 124,757,960(-) CAAAG(A/T)TTTCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for METTL10 Gene

Variant ID Type Subtype PubMed ID
esv3624817 CNV loss 21293372
nsv1050837 CNV gain 25217958
nsv1051396 CNV loss 25217958
nsv825604 CNV gain 20364138
nsv832013 CNV loss 17160897
nsv832014 CNV loss 17160897

Variation tolerance for METTL10 Gene

Residual Variation Intolerance Score: 76.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.75; 57.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for METTL10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
METTL10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL10 Gene

Disorders for METTL10 Gene

Relevant External Links for METTL10

Genetic Association Database (GAD)
METTL10
Human Genome Epidemiology (HuGE) Navigator
METTL10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
METTL10

No disorders were found for METTL10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL10 Gene

Publications for METTL10 Gene

  1. Selenium-based S-adenosylmethionine analog reveals the mammalian seven-beta-strand methyltransferase METTL10 to be an EF1A1 lysine methyltransferase. (PMID: 25144183) Shimazu T. … Shinkai Y. (PLoS ONE 2014) 2 3 64
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  3. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3 64
  5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 4 64

Products for METTL10 Gene

Sources for METTL10 Gene

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