Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



METTL1 Gene

protein-coding   GIFtS: 59
GCID: GC12M058174

Methyltransferase Like 1

(Previous name: methyltransferase-like 1)
(Previous symbol: C12orf1)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Methyltransferase Like 11 2     EC 2.1.1.333 8
C12orf11 2 3     TRM82
Methyltransferase-Like 11 2     TRMT82
Methyltransferase-Like Protein 12 3     YDL201w2
tRNA(m7G46)-methyltransferase2 3     D1075-Like Gene Product2
TRNA (Guanine(46)-N(7))-Methyltransferase2 3     TRNA (Guanine-N(7)-)-Methyltransferase2

External Ids:    HGNC: 70301   Entrez Gene: 42342   Ensembl: ENSG000000378977   OMIM: 6044665   UniProtKB: Q9UBP63   

Export aliases for METTL1 gene to outside databases

Previous GC identifers: GC12M057763 GC12M058305 GC12M057879 GC12M056448 GC12M058163 GC12M055199 GC12M058165 GC12M058170


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for METTL1 Gene:
This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved
S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding
different protein isoforms have been described for this gene. A pseudogene has been identified on chromosome X.
(provided by RefSeq, Jul 2008)

GeneCards Summary for METTL1 Gene:
METTL1 (methyltransferase like 1) is a protein-coding gene. GO annotations related to this gene include tRNA (guanine-N7-)-methyltransferase activity and tRNA binding.

UniProtKB/Swiss-Prot: TRMB_HUMAN, Q9UBP6
Function: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA

Gene Wiki entry for METTL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the METTL1 gene promoter:
         CREB   deltaCREB   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMETTL1 promoter sequence
   Search Chromatin IP Primers for METTL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat METTL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q14.1   HGNC cytogenetic band: 12q13

METTL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
METTL1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M058174:  view genomic region     (about GC identifiers)

Start:
58,162,254 bp from pter      End:
58,166,576 bp from pter
Size:
4,323 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TRMB_HUMAN, Q9UBP6 (See protein sequence)
Recommended Name: tRNA (guanine-N(7)-)-methyltransferase  
Size: 276 amino acids; 31471 Da
Subunit: Forms a complex with WDR4
Sequence caution: Sequence=CAA65470.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for METTL1:
3CKK (3D)    
Secondary accessions: B2RBX1 H7BXF2 Q14105 Q53FS9
Alternative splicing: 2 isoforms:  Q9UBP6-1   Q9UBP6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for METTL1: NX_Q9UBP6

Explore proteomics data for METTL1 at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-27 inactivates its catalytic activity but does not affect the interaction with WDR41
  • Ubiquitination2 at Lys250
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for METTL1 (Q9UBP6) (see all 9)
     KHKWRII  PTLLAEY  QNIACLR  TEEGKKV 


    See METTL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_005362.3  NP_075422.3  

    ENSEMBL proteins: 
     ENSP00000314441   ENSP00000257848   ENSP00000447838   ENSP00000449397   ENSP00000447988  
     ENSP00000448342  

    METTL1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for METTL1
    OriGene Protein Over-expression Lysate for METTL1
    OriGene MassSpec for METTL1
    OriGene Custom Protein Services for METTL1
    GenScript Custom Purified and Recombinant Proteins Services for METTL1
    Novus Biologicals METTL1 Proteins
    Novus Biologicals METTL1 Lysates
    Sino Biological Recombinant Protein for METTL1
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for METTL1
    Cloud-Clone Corp. Proteins for METTL1

     
    Search eBioscience for Proteins for METTL1 

     
    antibodies-online proteins for METTL1 (54 products) 

     
    antibodies-online peptides for METTL1

    METTL1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for METTL1
    Novus Biologicals METTL1 Antibodies
    Abcam antibodies for METTL1
    Cloud-Clone Corp. Antibodies for METTL1
    ThermoFisher Antibodies for METTL1
    antibodies-online antibodies for METTL1 (19 products) 

    METTL1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for METTL1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for METTL1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for METTL1
    Cloud-Clone Corp. CLIAs for METTL1
    Search eBioscience for ELISAs for METTL1 
    antibodies-online kits for METTL1 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR025763 Trm8_euk
     IPR003358 tRNA_(Gua-N-7)_MeTrfase

    Graphical View of Domain Structure for InterPro Entry Q9UBP6

    ProtoNet protein and cluster: Q9UBP6

    2 Blocks protein domains:
    IPB000515 Binding-protein-dependent transport systems inner membrane component
    IPB003358 Putative methyltransferase


    UniProtKB/Swiss-Prot: TRMB_HUMAN, Q9UBP6
    Similarity: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family


    Find genes that share domains with METTL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRMB_HUMAN, Q9UBP6
    Function: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
    Catalytic activity: S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine +
    N(7)-methylguanine(46) in tRNA

         Genatlas biochemistry entry for METTL1:
    methyltransferase-like 1

         Enzyme Number (IUBMB): EC 2.1.1.331 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000049tRNA binding IEA--
    GO:0005515protein binding IPI15861136
    GO:0008176contributes to tRNA (guanine-N7-)-methyltransferase activity IDA12403464
         
    Find genes that share ontologies with METTL1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for METTL1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat METTL1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate METTL1:
    hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidMETTL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for METTL1
    Predesigned siRNA for gene silencing in human, mouse, rat METTL1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for METTL1

    Clone
    Products:
         
    OriGene clones in human, mouse for METTL1 (see all 11)
    OriGene ORF clones in mouse, rat for METTL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): METTL1 (NM_005371)
    Sino Biological Human cDNA Clone for METTL1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for METTL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL1
    Addgene plasmids for METTL1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for METTL1
    Browse ESI BIO Cell Lines and PureStem Progenitors for METTL1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TRMB_HUMAN, Q9UBP6: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0043231intracellular membrane-bounded organelle ----

    Find genes that share ontologies with METTL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




    UniProtKB/Swiss-Prot: TRMB_HUMAN, Q9UBP6
    Pathway: tRNA modification; N(7)-methylguanine-tRNA biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for METTL1
    Interactions:

        GeneGlobe Interaction Network for METTL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for METTL1 (Q9UBP63 ENSP000003144414) via UniProtKB, MINT, STRING, and/or I2D (see all 84)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDX39BQ138383I2D: score=1 
    ENSG00000215425Q138383I2D: score=1 
    ENSG00000225073Q138383I2D: score=1 
    ENSG00000225859Q138383I2D: score=1 
    ENSG00000229496Q138383I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006400tRNA modification IDA12403464
    GO:0036265RNA (guanine-N7)-methylation IDA12403464

    Find genes that share ontologies with METTL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for METTL1 (TRMB)

    2 HMDB Compounds for METTL1    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for METTL1 gene (3 alternative transcripts): 
    NM_005371.5  NM_023033.3  NM_023032.1  

    Unigene Cluster for METTL1:

    Methyltransferase like 1
    Hs.42957  [show with all ESTs]
    Unigene Representative Sequence: BM811217
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000324871(uc010ssd.2 uc009zqc.3) ENST00000257848 ENST00000547653
    ENST00000548504 ENST00000551117 ENST00000553125 ENST00000548681 ENST00000549773

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat METTL1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate METTL1:
    hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidMETTL1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for METTL1
    Predesigned siRNA for gene silencing in human, mouse, rat METTL1
    Clone
    Products:
         
    OriGene clones in human, mouse for METTL1 (see all 11)
    OriGene ORF clones in mouse, rat for METTL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): METTL1 (NM_005371)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for METTL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL1
    Addgene plasmids for METTL1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for METTL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat METTL1
      QuantiTect SYBR Green Assays in human, mouse, rat METTL1
      QuantiFast Probe-based Assays in human, mouse, rat METTL1

    Additional mRNA sequence: 

    AK223202.1 AK314851.1 BC000550.1 X96698.1 Y18643.1 

    8 DOTS entries:

    DT.316148  DT.95206155  DT.100773472  DT.100773466  DT.101968573  DT.95078060  DT.102841110  DT.95374559 

    Selected AceView cDNA sequences (see all 201):

    BE293985 BF195899 BI820806 BE887016 AI818156 AI222585 BU689529 AW195105 
    AA341990 BG391631 CR595086 AI867306 AI521214 NM_023033 W24409 BQ651940 
    BM684610 BG059068 BI259784 AB005989 BU163668 CA487368 BE294824 Y18643 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for METTL1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
    SP1:              -           -     -                                       
    SP2:              -           -     -     -                                 
    SP3:              -     -     -     -                                       
    SP4:                          -     -                                       
    SP5:              -                                                         


    ECgene alternative splicing isoforms for METTL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    METTL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATATGTGTA
    METTL1 Expression
    About this image


    METTL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
    METTL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    METTL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.42957

    UniProtKB/Swiss-Prot: TRMB_HUMAN, Q9UBP6
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for METTL1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for METTL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat METTL1
    QuantiTect SYBR Green Assays in human, mouse, rat METTL1
    QuantiFast Probe-based Assays in human, mouse, rat METTL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for METTL1 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mettl11 , 5 methyltransferase like 11, 5 86.89(n)1
    90.64(a)1
      10 (74.50 cM)5
    172991  NM_010792.11  NP_034922.11 
     1270414145 
    lizard
    (Anolis carolinensis)
    Reptilia METTL16
    methyltransferase like 1
    76(a)
    1 ↔ 1
    2(66914868-66933895)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.110512 Transcribed sequence with moderate similarity to protein more 77.06(n)    142003409 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.283332 Transcribed sequence with weak similarity to protein more 75.9(n)    CF595110.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta EG:22E5.43
    CG40451
    CG40451 59(a)3
    64.1(n)1
    64.53(a)1
      2C103
    311761  NM_130622.31  NP_569978.11 
    worm
    (Caenorhabditis elegans)
    Secernentea W02B12.101 , 3 W02B12.101 59(a)3
    63.19(n)1
    64.78(a)1
      II(11472135-11473657)3
    1747531  NM_064047.31  NP_496448.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TRM8(YDL201W)4
    TRM81
    Subunit of a tRNA methyltransferase complex composed more4
    TRM81
    57.16(n)1
    60.74(a)1
      4(99561-100421)4
    8513261, 4  NP_010080.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G248401 AT5G24840 59.28(n)
    56.09(a)
      832553  NM_122393.3  NP_197866.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g02369001 Os06g0236900 62.87(n)
    63.29(a)
      4340601  NM_001063779.1  NP_001057244.1 


    ENSEMBL Gene Tree for METTL1 (if available)
    TreeFam Gene Tree for METTL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for METTL1 gene

    Find genes that share paralogs with METTL1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for METTL1
    PGOHUM00000260902


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for METTL1 (see all 49)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs778580921,2
    F--58162991(+) TGGCCC/TTTAGA 2 -- int11Minor allele frequency- T:0.50NA 4
    rs1875308581,2
    C--58163064(+) TCCACC/TTCCTC 2 -- int10--------
    rs2012475881,2
    --58163153(+) CGTGTA/GGCTCC 4 P L A mis1 syn10--------
    rs771949421,2
    C,F--58163265(+) TGAGTC/TCCTAA 2 -- int13Minor allele frequency- T:0.05WA NA EA 358
    rs1999339121,2
    --58163300(+) GAAGGG/TCCCCT 2 -- int10--------
    rs32168151,2
    C--58163305(-) TACTC-/AGGGGC 2 -- int10--------
    rs2002628171,2
    C--58163305(+) GCCCCC/TGAGTA 2 -- int10--------
    rs1900377631,2
    --58163388(+) GGGTGA/GGACTG 4 P L S mis1 syn10--------
    rs1411767951,2
    C--58163435(+) GGGTCG/AGGGAA 4 /P /R /* syn1 stg11Minor allele frequency- A:0.00NA 4552
    rs1425528981,2
    C--58163438(+) TCGGGG/AAAGAG 4 /F /P /S syn1 mis11Minor allele frequency- A:0.00NA 4552

    HapMap Linkage Disequilibrium report for METTL1 (58162254 - 58166576 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for METTL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv899121CNV Loss21882294
    nsv510601CNV Loss20534489
    nsv470296CNV Loss18288195
    nsv470297CNV Gain18288195

    Human Gene Mutation Database (HGMD): METTL1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing METTL1
    DNA2.0 Custom Variant and Variant Library Synthesis for METTL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604466    OMIM disorders: --


    Find genes that share disorders with METTL1           About GenesLikeMe

    Genetic Association Database (GAD): METTL1
    Human Genome Epidemiology (HuGE) Navigator: METTL1 (5 documents)

    Export disorders for METTL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for METTL1 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with METTL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular analysis of METTL1, a novel human methyltransferase-like gene with a high degree of phylogenetic conservation. (PubMed id 10329009)1, 2, 3, 9 Bahr A.... Schmidt E.R. (Genomics 1999)
    2. The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells. (PubMed id 15861136)1, 2, 3 Cartlidge R.A....Cohen P. (EMBO J. 2005)
    3. Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA. (PubMed id 12403464)1, 2, 9 Alexandrov A.... Phizicky E.M. (RNA 2002)
    4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    5. Infantile hypercalcemia and hypercalciuria: new insights into a vitamin D-dependent mechanism and response to ketoconazole treatment. (PubMed id 20394945)1, 4 Nguyen M....Garabedian M. (J. Pediatr. 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. (PubMed id 19525955)1, 4 (Nat. Genet. 2009)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4234 HGNC: 7030 AceView: CYP27B1andMETTL1 Ensembl:ENSG00000037897 euGenes: HUgn4234
    ECgene: METTL1 H-InvDB: METTL1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for METTL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for METTL1 gene:
    Search GeneIP for patents involving METTL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for METTL1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for METTL1  
     OriGene MassSpec for METTL1   OriGene clones in human, mouse for METTL1  
     OriGene qSTAR qPCR primer pairs in human, mouse for METTL1   OriGene Purified Protein for METTL1  
     OriGene ORF clones in mouse, rat for METTL1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for METTL1   OriGene Custom Protein Services for METTL1  

     
     
     Block miRNA regulation of human, mouse, rat METTL1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing METTL1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat METTL1 Predesigned siRNA for gene silencing in human, mouse, rat METTL1
     QuantiFast Probe-based Assays in human, mouse, rat METTL1 QuantiTect SYBR Green Assays in human, mouse, rat METTL1
     Custom PCR Arrays for METTL1 Search Chromatin IP Primers for METTL1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat METTL1  GeneGlobe Interaction Network for METTL1
     Regulatory tfbs in METTL1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for METTL1 GenScript cDNA clones with any tag delivered in your preferred vector for METTL1
     GenScript Custom Assay Services for METTL1 GenScript Custom overexpressing Cell Line Services for METTL1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for METTL1 (TRMB)
     Proteins for METTL1
     Browse Sino Biological Cell Lysates
     cDNA Clones for METTL1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     METTL1 antibodies
     METTL1 proteins
     METTL1 lysates
     Antibodies for METTL1
     See all of Abcam's Antibodies, Kits and Proteins for METTL1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for METTL1
     Proteins for METTL1
     Antibodies for METTL1
     ELISAs for METTL1
     CLIAs for METTL1



     Browse ESI BIO Cell Lines and PureStem Progenitors for METTL1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METTL1
     SwitchGear 3'UTR luciferase reporter plasmids for METTL1
     SwitchGear Promoter luciferase reporter plasmids for METTL1
     ThermoFisher Antibodies for METTL1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METTL1
     Browse compounds at ApexBio
     Addgene plasmids for METTL1
      Search eBioscience for proteins for METTL1
      Search eBioscience for elisas for METTL1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for METTL1
     antibodies-online antibodies for METTL1 (19 products)
     antibodies-online kits for METTL1 (6 products)
     antibodies-online peptides for METTL1
     antibodies-online proteins for METTL1 (54 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      METTL1 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4