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Aliases for METTL1 Gene

Aliases for METTL1 Gene

  • Methyltransferase Like 1 2 3
  • TRNA (Guanine(46)-N(7))-Methyltransferase 3 4
  • Methyltransferase-Like Protein 1 3 4
  • TRNA(M7G46)-Methyltransferase 3 4
  • Methyltransferase-Like 1 2 3
  • EC 4 63
  • C12orf1 3 4
  • TRNA (Guanine-N(7)-)-Methyltransferase 3
  • D1075-Like Gene Product 3
  • YDL201w 3
  • TRMT8 3
  • TRM8 3

External Ids for METTL1 Gene

Previous HGNC Symbols for METTL1 Gene

  • C12orf1

Previous GeneCards Identifiers for METTL1 Gene

  • GC12M058305
  • GC12M057879
  • GC12M056448
  • GC12M058163
  • GC12M055199
  • GC12M058165
  • GC12M058170
  • GC12M058174

Summaries for METTL1 Gene

Entrez Gene Summary for METTL1 Gene

  • This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms have been described for this gene. A pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2008]

GeneCards Summary for METTL1 Gene

METTL1 (Methyltransferase Like 1) is a Protein Coding gene. GO annotations related to this gene include tRNA binding and tRNA (guanine-N7-)-methyltransferase activity.

UniProtKB/Swiss-Prot for METTL1 Gene

  • Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.

Gene Wiki entry for METTL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL1 Gene

Genomics for METTL1 Gene

Regulatory Elements for METTL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for METTL1 Gene

57,768,471 bp from pter
57,772,793 bp from pter
4,323 bases
Minus strand

Genomic View for METTL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for METTL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL1 Gene

Proteins for METTL1 Gene

  • Protein details for METTL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferase
    Protein Accession:
    Secondary Accessions:
    • B2RBX1
    • H7BXF2
    • Q14105
    • Q53FS9

    Protein attributes for METTL1 Gene

    276 amino acids
    Molecular mass:
    31471 Da
    Quaternary structure:
    • Forms a complex with WDR4.
    • Sequence=CAA65470.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for METTL1 Gene

    Alternative splice isoforms for METTL1 Gene


neXtProt entry for METTL1 Gene

Proteomics data for METTL1 Gene at MOPED

Selected DME Specific Peptides for METTL1 Gene

Post-translational modifications for METTL1 Gene

  • Phosphorylation at Ser-27 inactivates its catalytic activity but does not affect the interaction with WDR4.
  • Ubiquitination at Lys250
  • Modification sites at PhosphoSitePlus

Other Protein References for METTL1 Gene

Antibody Products

Domains for METTL1 Gene

Suggested Antigen Peptide Sequences for METTL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9UBP6
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
genes like me logo Genes that share domains with METTL1: view

No data available for Gene Families for METTL1 Gene

Function for METTL1 Gene

Molecular function for METTL1 Gene

GENATLAS Biochemistry:
methyltransferase-like 1
UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.
UniProtKB/Swiss-Prot Function:
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.

Enzyme Numbers (IUBMB) for METTL1 Gene

Gene Ontology (GO) - Molecular Function for METTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IEA --
GO:0005515 protein binding IPI 15861136
GO:0008176 contributes_to tRNA (guanine-N7-)-methyltransferase activity IDA 12403464
genes like me logo Genes that share ontologies with METTL1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for METTL1

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for METTL1 Gene

Localization for METTL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL1 Gene

Subcellular locations from

Jensen Localization Image for METTL1 Gene COMPARTMENTS Subcellular localization image for METTL1 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for METTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0043527 tRNA methyltransferase complex IBA --
genes like me logo Genes that share ontologies with METTL1: view

Pathways for METTL1 Gene

SuperPathways for METTL1 Gene

No Data Available

UniProtKB/Swiss-Prot Q9UBP6-TRMB_HUMAN

  • Pathway: tRNA modification; N(7)-methylguanine-tRNA biosynthesis.

Gene Ontology (GO) - Biological Process for METTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006400 tRNA modification IDA 12403464
GO:0030488 tRNA methylation IBA --
GO:0036265 RNA (guanine-N7)-methylation IEA --
genes like me logo Genes that share ontologies with METTL1: view

No data available for Pathways by source for METTL1 Gene

Compounds for METTL1 Gene

(2) HMDB Compounds for METTL1 Gene

Compound Synonyms Cas Number PubMed IDs
  • (S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
genes like me logo Genes that share compounds with METTL1: view

Transcripts for METTL1 Gene

Unigene Clusters for METTL1 Gene

Methyltransferase like 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for METTL1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - -
SP5: -
SP6: -

Relevant External Links for METTL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METTL1 Gene

mRNA expression in normal human tissues for METTL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for METTL1 Gene

This gene is overexpressed in Lung (11.9), Lymph node (10.4), and Islet of Langerhans (8.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for METTL1 Gene

SOURCE GeneReport for Unigene cluster for METTL1 Gene Hs.42957

mRNA Expression by UniProt/SwissProt for METTL1 Gene

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with METTL1: view

Expression partners for METTL1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for METTL1 Gene

Orthologs for METTL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METTL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia METTL1 35
  • 91.27 (n)
  • 92 (a)
  • 91 (a)
(Canis familiaris)
Mammalia METTL1 35
  • 90.22 (n)
  • 92.44 (a)
  • 90 (a)
(Mus musculus)
Mammalia Mettl1 35
  • 86.89 (n)
  • 90.64 (a)
Mettl1 16
Mettl1 36
  • 90 (a)
(Pan troglodytes)
Mammalia METTL1 35
  • 99.28 (n)
  • 98.91 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Mettl1 35
  • 87.77 (n)
  • 91.01 (a)
(Monodelphis domestica)
Mammalia METTL1 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia METTL1 36
  • 74 (a)
(Anolis carolinensis)
Reptilia METTL1 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl1 35
  • 67.05 (n)
  • 73.18 (a)
Str.11051 35
(Danio rerio)
Actinopterygii Dr.28333 35
mettl1 35
  • 70.51 (n)
  • 77.35 (a)
mettl1 36
  • 75 (a)
fruit fly
(Drosophila melanogaster)
Insecta EG:22E5.4 37
  • 59 (a)
CG4045 35
  • 64.1 (n)
  • 64.53 (a)
CG4045 36
  • 58 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta TRMB_ANOGA 35
  • 60.12 (n)
  • 63.84 (a)
(Caenorhabditis elegans)
Secernentea W02B12.10 37
  • 59 (a)
W02B12.10 35
  • 63.19 (n)
  • 64.78 (a)
W02B12.10 36
  • 58 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR192C 35
  • 61.43 (n)
  • 59.5 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A03245g 35
  • 57.69 (n)
  • 61.11 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRM8 35
  • 57.16 (n)
  • 60.74 (a)
TRM8 36
  • 52 (a)
TRM8 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G24840 35
  • 59.28 (n)
  • 56.09 (a)
(Oryza sativa)
Liliopsida Os06g0236900 35
  • 62.87 (n)
  • 63.29 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03936 35
  • 59.65 (n)
  • 56.28 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes trm8 35
  • 56.82 (n)
  • 58.65 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5350 36
  • 60 (a)
Species with no ortholog for METTL1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL1 Gene

Gene Tree for METTL1 (if available)
Gene Tree for METTL1 (if available)

Paralogs for METTL1 Gene Pseudogenes for METTL1 Gene

genes like me logo Genes that share paralogs with METTL1: view

No data available for Paralogs for METTL1 Gene

Variants for METTL1 Gene

Sequence variations from dbSNP and Humsavar for METTL1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs3216815 -- 57,769,522(-) TACTC(-/A)GGGGC intron-variant
rs61756705 -- 57,769,829(+) CAGGC(A/G)ATGTT reference, synonymous-codon, intron-variant
rs77194942 -- 57,769,482(+) TGAGT(C/T)CCTAA intron-variant
rs77858092 -- 57,769,208(+) TGGCC(C/T)TTAGA intron-variant
rs111685053 -- 57,770,073(+) AGAGA(A/G)GACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for METTL1 Gene

Variant ID Type Subtype PubMed ID
nsv899121 CNV Loss 21882294
nsv470296 CNV Loss 18288195
nsv510601 CNV Loss 20534489
nsv470297 CNV Gain 18288195

Relevant External Links for METTL1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL1 Gene

Disorders for METTL1 Gene

Relevant External Links for METTL1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for METTL1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for METTL1 Gene

Publications for METTL1 Gene

  1. Molecular analysis of METTL1, a novel human methyltransferase-like gene with a high degree of phylogenetic conservation. (PMID: 10329009) Bahr A. … Schmidt E.R. (Genomics 1999) 2 3 4 23
  2. Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA. (PMID: 12403464) Alexandrov A. … Phizicky E.M. (RNA 2002) 3 4 23
  3. The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells. (PMID: 15861136) Cartlidge R.A. … Cohen P. (EMBO J. 2005) 2 3 4
  4. Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. (PMID: 19525955) (Nat. Genet. 2009) 3 48
  5. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 48

Products for METTL1 Gene

Sources for METTL1 Gene

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