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Aliases for METTL1 Gene

Aliases for METTL1 Gene

  • Methyltransferase Like 1 2 3 5
  • TRNA (Guanine(46)-N(7))-Methyltransferase 3 4
  • Methyltransferase-Like Protein 1 3 4
  • TRNA(M7G46)-Methyltransferase 3 4
  • Methyltransferase-Like 1 2 3
  • EC 2.1.1.33 4 63
  • C12orf1 3 4
  • D1075-Like Gene Product 3
  • YDL201w 3
  • TRMT8 3
  • TRM8 3

External Ids for METTL1 Gene

Previous HGNC Symbols for METTL1 Gene

  • C12orf1

Previous GeneCards Identifiers for METTL1 Gene

  • GC12M058305
  • GC12M057879
  • GC12M056448
  • GC12M058163
  • GC12M055199
  • GC12M058165
  • GC12M058170
  • GC12M058174

Summaries for METTL1 Gene

Entrez Gene Summary for METTL1 Gene

  • This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms have been described for this gene. A pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2008]

GeneCards Summary for METTL1 Gene

METTL1 (Methyltransferase Like 1) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. GO annotations related to this gene include tRNA binding and tRNA (guanine-N7-)-methyltransferase activity.

UniProtKB/Swiss-Prot for METTL1 Gene

  • Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.

Gene Wiki entry for METTL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METTL1 Gene

Genomics for METTL1 Gene

Regulatory Elements for METTL1 Gene

Promoters for METTL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around METTL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for METTL1 Gene

Chromosome:
12
Start:
57,768,471 bp from pter
End:
57,772,793 bp from pter
Size:
4,323 bases
Orientation:
Minus strand

Genomic View for METTL1 Gene

Genes around METTL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL1 Gene

Proteins for METTL1 Gene

  • Protein details for METTL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBP6-TRMB_HUMAN
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferase
    Protein Accession:
    Q9UBP6
    Secondary Accessions:
    • B2RBX1
    • H7BXF2
    • Q14105
    • Q53FS9

    Protein attributes for METTL1 Gene

    Size:
    276 amino acids
    Molecular mass:
    31471 Da
    Quaternary structure:
    • Forms a complex with WDR4.
    SequenceCaution:
    • Sequence=CAA65470.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for METTL1 Gene

    Alternative splice isoforms for METTL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for METTL1 Gene

Proteomics data for METTL1 Gene at MOPED

Selected DME Specific Peptides for METTL1 Gene

Post-translational modifications for METTL1 Gene

  • Phosphorylation at Ser-27 inactivates its catalytic activity but does not affect the interaction with WDR4.
  • Ubiquitination at Lys 250
  • Modification sites at PhosphoSitePlus

Other Protein References for METTL1 Gene

Antibody Products

Domains & Families for METTL1 Gene

Gene Families for METTL1 Gene

Suggested Antigen Peptide Sequences for METTL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UBP6

UniProtKB/Swiss-Prot:

TRMB_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
genes like me logo Genes that share domains with METTL1: view

Function for METTL1 Gene

Molecular function for METTL1 Gene

GENATLAS Biochemistry:
methyltransferase-like 1
UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.
UniProtKB/Swiss-Prot Function:
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.

Enzyme Numbers (IUBMB) for METTL1 Gene

Gene Ontology (GO) - Molecular Function for METTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IEA --
genes like me logo Genes that share ontologies with METTL1: view
genes like me logo Genes that share phenotypes with METTL1: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL1 Gene

Localization for METTL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for METTL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for METTL1 Gene COMPARTMENTS Subcellular localization image for METTL1 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for METTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with METTL1: view

Pathways & Interactions for METTL1 Gene

genes like me logo Genes that share pathways with METTL1: view

Pathways by source for METTL1 Gene

UniProtKB/Swiss-Prot Q9UBP6-TRMB_HUMAN

  • Pathway: tRNA modification; N(7)-methylguanine-tRNA biosynthesis.

SIGNOR curated interactions for METTL1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for METTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006400 tRNA modification IEA,IDA 12403464
GO:0030488 tRNA methylation IEA --
genes like me logo Genes that share ontologies with METTL1: view

Drugs & Compounds for METTL1 Gene

(2) Drugs for METTL1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma 0
genes like me logo Genes that share compounds with METTL1: view

Transcripts for METTL1 Gene

Unigene Clusters for METTL1 Gene

Methyltransferase like 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for METTL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - -
SP5: -
SP6: -

Relevant External Links for METTL1 Gene

GeneLoc Exon Structure for
METTL1
ECgene alternative splicing isoforms for
METTL1

Expression for METTL1 Gene

mRNA expression in normal human tissues for METTL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for METTL1 Gene

This gene is overexpressed in Lung (11.9), Lymph node (10.4), and Islet of Langerhans (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for METTL1 Gene



SOURCE GeneReport for Unigene cluster for METTL1 Gene Hs.42957

mRNA Expression by UniProt/SwissProt for METTL1 Gene

Q9UBP6-TRMB_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with METTL1: view

Protein tissue co-expression partners for METTL1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for METTL1 Gene

Orthologs for METTL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METTL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL1 35
  • 99.28 (n)
  • 98.91 (a)
METTL1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia METTL1 36
  • 91 (a)
OneToOne
METTL1 35
  • 91.27 (n)
  • 92 (a)
dog
(Canis familiaris)
Mammalia METTL1 35
  • 90.22 (n)
  • 92.44 (a)
METTL1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mettl1 16
Mettl1 35
  • 86.89 (n)
  • 90.64 (a)
Mettl1 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia METTL1 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia METTL1 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mettl1 35
  • 87.77 (n)
  • 91.01 (a)
lizard
(Anolis carolinensis)
Reptilia METTL1 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mettl1 35
  • 67.05 (n)
  • 73.18 (a)
Str.11051 35
zebrafish
(Danio rerio)
Actinopterygii Dr.28333 35
mettl1 35
  • 70.51 (n)
  • 77.35 (a)
mettl1 36
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta TRMB_ANOGA 35
  • 60.12 (n)
  • 63.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta EG:22E5.4 37
  • 59 (a)
CG4045 35
  • 64.1 (n)
  • 64.53 (a)
CG4045 36
  • 58 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea W02B12.10 36
  • 58 (a)
OneToOne
W02B12.10 37
  • 59 (a)
W02B12.10 35
  • 63.19 (n)
  • 64.78 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR192C 35
  • 61.43 (n)
  • 59.5 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRM8 35
  • 57.16 (n)
  • 60.74 (a)
TRM8 36
  • 52 (a)
OneToOne
TRM8 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A03245g 35
  • 57.69 (n)
  • 61.11 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G24840 35
  • 59.28 (n)
  • 56.09 (a)
rice
(Oryza sativa)
Liliopsida Os06g0236900 35
  • 62.87 (n)
  • 63.29 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03936 35
  • 59.65 (n)
  • 56.28 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes trm8 35
  • 56.82 (n)
  • 58.65 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5350 36
  • 60 (a)
OneToOne
Species with no ortholog for METTL1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for METTL1 Gene

ENSEMBL:
Gene Tree for METTL1 (if available)
TreeFam:
Gene Tree for METTL1 (if available)

Paralogs for METTL1 Gene

Pseudogenes.org Pseudogenes for METTL1 Gene

genes like me logo Genes that share paralogs with METTL1: view

No data available for Paralogs for METTL1 Gene

Variants for METTL1 Gene

Sequence variations from dbSNP and Humsavar for METTL1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs61756705 -- 57,769,829(+) CAGGC(A/G)ATGTT intron-variant, reference, synonymous-codon
rs77858092 -- 57,769,208(+) TGGCC(C/T)TTAGA intron-variant
rs118007790 -- 57,769,921(+) ACCCA(A/G)AATAA intron-variant, reference, synonymous-codon
rs144161481 -- 57,769,378(+) TCCAG(C/G)ACATC reference, synonymous-codon, missense
rs150961086 -- 57,769,828(+) ACAGG(C/T)GATGT intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for METTL1 Gene

Variant ID Type Subtype PubMed ID
nsv899121 CNV Loss 21882294
nsv470296 CNV Loss 18288195
nsv510601 CNV Loss 20534489
nsv470297 CNV Gain 18288195

Variation tolerance for METTL1 Gene

Residual Variation Intolerance Score: 14.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for METTL1 Gene

HapMap Linkage Disequilibrium report
METTL1
Human Gene Mutation Database (HGMD)
METTL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METTL1 Gene

Disorders for METTL1 Gene

Relevant External Links for METTL1

Genetic Association Database (GAD)
METTL1
Human Genome Epidemiology (HuGE) Navigator
METTL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
METTL1

No disorders were found for METTL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METTL1 Gene

Publications for METTL1 Gene

  1. Molecular analysis of METTL1, a novel human methyltransferase-like gene with a high degree of phylogenetic conservation. (PMID: 10329009) Bahr A. … Schmidt E.R. (Genomics 1999) 2 3 4 23 67
  2. The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells. (PMID: 15861136) Cartlidge R.A. … Cohen P. (EMBO J. 2005) 2 3
  3. Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA. (PMID: 12403464) Alexandrov A. … Phizicky E.M. (RNA 2002) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for METTL1 Gene

Sources for METTL1 Gene

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