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Aliases for METRNL Gene

Aliases for METRNL Gene

  • Meteorin, Glial Cell Differentiation Regulator-Like 2 3 5
  • Subfatin 3 4

External Ids for METRNL Gene

Previous GeneCards Identifiers for METRNL Gene

  • GC17P078631
  • GC17P081037
  • GC17P076439

Summaries for METRNL Gene

GeneCards Summary for METRNL Gene

METRNL (Meteorin, Glial Cell Differentiation Regulator-Like) is a Protein Coding gene. GO annotations related to this gene include hormone activity. An important paralog of this gene is METRN.

UniProtKB/Swiss-Prot for METRNL Gene

  • Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METRNL Gene

Genomics for METRNL Gene

Regulatory Elements for METRNL Gene

Enhancers for METRNL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around METRNL on UCSC Golden Path with GeneCards custom track

Promoters for METRNL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around METRNL on UCSC Golden Path with GeneCards custom track

Genomic Location for METRNL Gene

Chromosome:
17
Start:
83,079,691 bp from pter
End:
83,095,129 bp from pter
Size:
15,439 bases
Orientation:
Plus strand

Genomic View for METRNL Gene

Genes around METRNL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METRNL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METRNL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METRNL Gene

Proteins for METRNL Gene

  • Protein details for METRNL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q641Q3-METRL_HUMAN
    Recommended name:
    Meteorin-like protein
    Protein Accession:
    Q641Q3
    Secondary Accessions:
    • B3KSJ5
    • Q86VM0

    Protein attributes for METRNL Gene

    Size:
    311 amino acids
    Molecular mass:
    34398 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH50568.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for METRNL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for METRNL Gene

Proteomics data for METRNL Gene at MOPED

Post-translational modifications for METRNL Gene

  • Glycosylation at Thr 215
  • Modification sites at PhosphoSitePlus

Other Protein References for METRNL Gene

No data available for DME Specific Peptides for METRNL Gene

Domains & Families for METRNL Gene

Protein Domains for METRNL Gene

ProtoNet:

Suggested Antigen Peptide Sequences for METRNL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q641Q3

UniProtKB/Swiss-Prot:

METRL_HUMAN :
  • Belongs to the meteorin family.
Family:
  • Belongs to the meteorin family.
genes like me logo Genes that share domains with METRNL: view

No data available for Gene Families for METRNL Gene

Function for METRNL Gene

Molecular function for METRNL Gene

UniProtKB/Swiss-Prot Function:
Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity).
genes like me logo Genes that share phenotypes with METRNL: view

Animal Models for METRNL Gene

MGI Knock Outs for METRNL:

Animal Model Products

  • Taconic Biosciences Mouse Models for METRNL

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for METRNL Gene

Localization for METRNL Gene

Subcellular locations from UniProtKB/Swiss-Prot for METRNL Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for METRNL Gene COMPARTMENTS Subcellular localization image for METRNL gene
Compartment Confidence
extracellular 5
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for METRNL Gene

Pathways & Interactions for METRNL Gene

SuperPathways for METRNL Gene

No Data Available

Interacting Proteins for METRNL Gene

Gene Ontology (GO) - Biological Process for METRNL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014850 response to muscle activity ISS --
GO:0050728 negative regulation of inflammatory response ISS --
GO:0090336 positive regulation of brown fat cell differentiation ISS --
GO:2000507 positive regulation of energy homeostasis ISS --
genes like me logo Genes that share ontologies with METRNL: view

No data available for Pathways by source and SIGNOR curated interactions for METRNL Gene

Drugs & Compounds for METRNL Gene

No Compound Related Data Available

Transcripts for METRNL Gene

Unigene Clusters for METRNL Gene

Meteorin, glial cell differentiation regulator-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for METRNL Gene

No ASD Table

Relevant External Links for METRNL Gene

GeneLoc Exon Structure for
METRNL
ECgene alternative splicing isoforms for
METRNL

Expression for METRNL Gene

mRNA expression in normal human tissues for METRNL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for METRNL Gene

This gene is overexpressed in Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for METRNL Gene

This gene is overexpressed in Plasma (64.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for METRNL Gene



SOURCE GeneReport for Unigene cluster for METRNL Gene Hs.378821

mRNA Expression by UniProt/SwissProt for METRNL Gene

Q641Q3-METRL_HUMAN
Tissue specificity: Highly expressed in the skeletal muscle, in subcutaneous adipose tissue, epididymal white adipose tissue depots and heart. Also expressed in brown adipose tissues and kidney.
genes like me logo Genes that share expression patterns with METRNL: view

Protein tissue co-expression partners for METRNL Gene

- Elite partner

Primer Products

Orthologs for METRNL Gene

This gene was present in the common ancestor of chordates.

Orthologs for METRNL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia METRNL 35
  • 84.31 (n)
  • 82.79 (a)
METRNL 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia METRNL 35
  • 83.14 (n)
  • 80.75 (a)
METRNL 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Metrnl 35
  • 78.45 (n)
  • 78.57 (a)
Metrnl 16
Metrnl 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia METRNL 35
  • 98.69 (n)
  • 97.65 (a)
METRNL 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Metrnl 35
  • 78.95 (n)
  • 79.7 (a)
oppossum
(Monodelphis domestica)
Mammalia METRNL 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia METRNL 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves METRNL 35
  • 72.46 (n)
  • 75.1 (a)
METRNL 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia METRNL 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia metrnl 35
  • 66.41 (n)
  • 65.53 (a)
Str.6134 35
zebrafish
(Danio rerio)
Actinopterygii Dr.17200 35
metrnl 35
  • 62.25 (n)
  • 57.58 (a)
metrnl 36
  • 55 (a)
OneToMany
METRNL (1 of 2) 36
  • 48 (a)
OneToMany
Species with no ortholog for METRNL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for METRNL Gene

ENSEMBL:
Gene Tree for METRNL (if available)
TreeFam:
Gene Tree for METRNL (if available)

Paralogs for METRNL Gene

Paralogs for METRNL Gene

(1) SIMAP similar genes for METRNL Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with METRNL: view

Variants for METRNL Gene

Sequence variations from dbSNP and Humsavar for METRNL Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs8269 -- 83,094,678(-) GGGCA(C/T)GCGGC utr-variant-3-prime
rs1133217 -- 83,094,662(+) GGGCC(A/G)CGCGC utr-variant-3-prime
rs4072444 -- 83,090,957(+) GGGGT(C/T)CACAT intron-variant
rs4072523 -- 83,089,953(+) AGGGC(A/G)GGGTA intron-variant
rs4986078 -- 83,078,678(+) CCCCC(A/C)ACTGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for METRNL Gene

Variant ID Type Subtype PubMed ID
esv21913 CNV Gain+Loss 19812545
nsv909268 CNV Gain 21882294
nsv828147 CNV Loss 20364138
dgv3372n71 CNV Loss 21882294
dgv3373n71 CNV Loss 21882294
nsv828149 CNV Gain 20364138
nsv529045 CNV Loss 19592680
nsv819941 CNV Gain 19587683
dgv3374n71 CNV Loss 21882294
nsv909283 CNV Loss 21882294
nsv522768 CNV Loss 19592680
nsv828150 CNV Gain 20364138

Variation tolerance for METRNL Gene

Residual Variation Intolerance Score: 54.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.78; 47.22% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for METRNL Gene

Disorders for METRNL Gene

Relevant External Links for METRNL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
METRNL

No disorders were found for METRNL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METRNL Gene

Publications for METRNL Gene

  1. Subfatin is a novel adipokine and unlike Meteorin in adipose and brain expression. (PMID: 24393292) Li Z.Y. … Miao C.Y. (CNS Neurosci. Ther. 2014) 3 4 67
  2. Adipocyte Metrnl Antagonizes Insulin Resistance Through PPARI^ Signaling. (PMID: 26307585) Li Z.Y. … Miao C.Y. (Diabetes 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). (PMID: 19199708) Gonzalez-Begne M. … Yates J.R. (J. Proteome Res. 2009) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for METRNL Gene

Sources for METRNL Gene

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