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Aliases for METRN Gene

Aliases for METRN Gene

  • Meteorin, Glial Cell Differentiation Regulator 2 3
  • C16orf23 3 4
  • Chromosome 16 Open Reading Frame 23 2
  • C380A1.2 3
  • Meteorin 3

External Ids for METRN Gene

Previous HGNC Symbols for METRN Gene

  • C16orf23

Previous GeneCards Identifiers for METRN Gene

  • GC16P000709
  • GC16P000765

Summaries for METRN Gene

Entrez Gene Summary for METRN Gene

  • Meteorin regulates glial cell differentiation and promotes the formation of axonal networks during neurogenesis (Nishino et al., 2004 [PubMed 15085178]).[supplied by OMIM, Mar 2008]

GeneCards Summary for METRN Gene

METRN (Meteorin, Glial Cell Differentiation Regulator) is a Protein Coding gene. An important paralog of this gene is METRNL.

UniProtKB/Swiss-Prot for METRN Gene

  • Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METRN Gene

Genomics for METRN Gene

Regulatory Elements for METRN Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for METRN Gene

Start:
715,115 bp from pter
End:
719,655 bp from pter
Size:
4,541 bases
Orientation:
Plus strand

Genomic View for METRN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for METRN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METRN Gene

Proteins for METRN Gene

  • Protein details for METRN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJH8-METRN_HUMAN
    Recommended name:
    Meteorin
    Protein Accession:
    Q9UJH8
    Secondary Accessions:
    • Q9UJH9

    Protein attributes for METRN Gene

    Size:
    293 amino acids
    Molecular mass:
    31207 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for METRN Gene

Proteomics data for METRN Gene at MOPED

Post-translational modifications for METRN Gene

Other Protein References for METRN Gene

No data available for DME Specific Peptides for METRN Gene

Domains for METRN Gene

Protein Domains for METRN Gene

ProtoNet:

Suggested Antigen Peptide Sequences for METRN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UJH8

UniProtKB/Swiss-Prot:

METRN_HUMAN :
  • Q9UJH8
Family:
  • Belongs to the meteorin family.
genes like me logo Genes that share domains with METRN: view

No data available for Gene Families for METRN Gene

Function for METRN Gene

Molecular function for METRN Gene

UniProtKB/Swiss-Prot Function: Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia (By similarity).

Phenotypes for METRN Gene

GenomeRNAi human phenotypes for METRN:
genes like me logo Genes that share phenotypes with METRN: view

Animal Model Products

CRISPR Products

miRNA for METRN Gene

miRTarBase miRNAs that target METRN

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for METRN

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for METRN Gene

Localization for METRN Gene

Subcellular locations from UniProtKB/Swiss-Prot for METRN Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for METRN Gene COMPARTMENTS Subcellular localization image for METRN gene
Compartment Confidence
extracellular 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for METRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with METRN: view

Pathways for METRN Gene

SuperPathways for METRN Gene

No Data Available

Interacting Proteins for METRN Gene

Gene Ontology (GO) - Biological Process for METRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010001 glial cell differentiation IEA --
GO:0050772 positive regulation of axonogenesis IEA --
genes like me logo Genes that share ontologies with METRN: view

No data available for Pathways by source for METRN Gene

Transcripts for METRN Gene

mRNA/cDNA for METRN Gene

Unigene Clusters for METRN Gene

Meteorin, glial cell differentiation regulator:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for METRN

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for METRN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for METRN Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: - -
SP2: -
SP3:

Relevant External Links for METRN Gene

GeneLoc Exon Structure for
METRN
ECgene alternative splicing isoforms for
METRN

Expression for METRN Gene

mRNA expression in normal human tissues for METRN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for METRN Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (4.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for METRN Gene

SOURCE GeneReport for Unigene cluster for METRN Gene Hs.533772

genes like me logo Genes that share expressions with METRN: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for METRN Gene

Orthologs for METRN Gene

This gene was present in the common ancestor of chordates.

Orthologs for METRN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METRN 35
  • 98.63 (n)
  • 98.63 (a)
METRN 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia METRN 35
  • 84.73 (n)
  • 80.73 (a)
METRN 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia METRN 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Metrn 35
  • 81.32 (n)
  • 81.68 (a)
Metrn 16
Metrn 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia METRN 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia METRN 36
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Metrn 35
  • 80.71 (n)
  • 81.32 (a)
chicken
(Gallus gallus)
Aves METRN 35
  • 70.4 (n)
  • 62.93 (a)
METRN 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia METRN 36
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii metrn 35
  • 59.33 (n)
  • 54.48 (a)
metrn 36
  • 47 (a)
OneToOne
Species with no ortholog for METRN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for METRN Gene

ENSEMBL:
Gene Tree for METRN (if available)
TreeFam:
Gene Tree for METRN (if available)

Paralogs for METRN Gene

Paralogs for METRN Gene

Selected SIMAP similar genes for METRN Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with METRN: view

Variants for METRN Gene

Sequence variations from dbSNP and Humsavar for METRN Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs10682 -- 717,430(-) AGTGG(C/G)CCCAC utr-variant-3-prime
rs730624 -- 717,862(+) GGTAC(A/G)GTGGG downstream-variant-500B
rs1076939 -- 716,001(+) TCTGG(G/T)TGGGA intron-variant
rs3809663 -- 714,040(+) CGTCC(A/G)TAAGG upstream-variant-2KB
rs3809664 -- 714,090(+) GCCTT(C/G)TGTGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for METRN Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv904707 CNV Loss 21882294
nsv526903 CNV Loss 19592680
dgv2475n71 CNV Loss 21882294
dgv2479n71 CNV Loss 21882294
nsv471063 CNV Loss 18288195
dgv2485n71 CNV Loss 21882294
nsv904759 CNV Loss 21882294
nsv516590 CNV Loss 19592680
dgv2488n71 CNV Loss 21882294
nsv904781 CNV Gain 21882294
nsv471065 CNV Gain 18288195
dgv2490n71 CNV Loss 21882294
nsv9321 CNV Gain+Loss 18304495
dgv2491n71 CNV Loss 21882294
nsv904796 CNV Loss 21882294
nsv904797 CNV Loss 21882294
dgv2492n71 CNV Loss 21882294
nsv457311 CNV Loss 19166990
dgv2495n71 CNV Loss 21882294
nsv904812 CNV Loss 21882294
dgv2496n71 CNV Loss 21882294

Relevant External Links for METRN Gene

HapMap Linkage Disequilibrium report
METRN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METRN Gene

Disorders for METRN Gene

No disorders were found for METRN Gene.

No data available for UniProtKB/Swiss-Prot for METRN Gene

Publications for METRN Gene

  1. Meteorin: a secreted protein that regulates glial cell differentiation and promotes axonal extension. (PMID: 15085178) Nishino J. … Hamada H. (EMBO J. 2004) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4
  4. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels R.J. … Higgs D.R. (Hum. Mol. Genet. 2001) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for METRN Gene

Sources for METRN Gene

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