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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

METAP2 Gene

protein-coding   GIFtS: 67
GCID: GC12P095800

Methionyl Aminopeptidase 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Methionyl Aminopeptidase 21 2     p67eIF22 3
Peptidase M1 3     MAP22
Initiation Factor 2-Associated 67 KDa Glycoprotein2 3     EIF-2-Associated P67 Homolog2
MetAP 22 3     Methionine Aminopeptidase 22
MNPEP2 3     Peptidase M 22
MAP 22 3     EC 3.4.11.183
p672 3     P67EIF23

External Ids:    HGNC: 166721   Entrez Gene: 109882   Ensembl: ENSG000001111427   OMIM: 6018705   UniProtKB: P505793   

Export aliases for METAP2 gene to outside databases

Previous GC identifers: GC12M095311 GC12P096231 GC12P094370 GC12P092936


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for METAP2 Gene:
This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or
manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2
from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein.
Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin
and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located
on chromosome 2. (provided by RefSeq, Jul 2008)

GeneCards Summary for METAP2 Gene: 
METAP2 (methionyl aminopeptidase 2) is a protein-coding gene. Diseases associated with METAP2 include microsporidiosis, and neurofibromatosis, and among its related super-pathways are Visual signal transduction- Rods and Retinoid metabolism and transport. GO annotations related to this gene include metalloexopeptidase activity and aminopeptidase activity. An important paralog of this gene is ENSG00000257411.

UniProtKB/Swiss-Prot: MAP2_HUMAN, P50579
Function: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is
often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro,
Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of
magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing
N-terminal Met-Val and Met-Thr sequences in vivo
Function: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory
kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis

Gene Wiki entry for METAP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the METAP2 gene promoter:
         AML1a   AP-1   ATF-2   HSF1 (long)   Max   NRF-2   HSF1short   c-Jun   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMETAP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for METAP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METAP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q22   Ensembl cytogenetic band:  12q22   HGNC cytogenetic band: 12q22

METAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
METAP2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P095800:  view genomic region     (about GC identifiers)

Start:
95,867,296 bp from pter      End:
95,909,615 bp from pter
Size:
42,320 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MAP2_HUMAN, P50579 (See protein sequence)
Recommended Name: Methionine aminopeptidase 2  
Size: 478 amino acids; 52892 Da
Cofactor: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site.
The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese
or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases
under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the
histidine-containing high-affinity site (By similarity). Also manganese has been proposed to be the physiological
cofactor for human METAP2
Subunit: Interacts strongly with the eIF-2 gamma-subunit EIF2S3 (By similarity). Binds EIF2S1 at low magnesium
concentrations
Subcellular location: Cytoplasm. Note=About 30% of expressed METAP2 associates with polysomes
6/18 PDB 3D structures from and Proteopedia for METAP2 (see all 18):
1B59 (3D)        1B6A (3D)        1BN5 (3D)        1BOA (3D)        1KQ0 (3D)        1KQ9 (3D)    
Secondary accessions: B2RDI8

Explore the universe of human proteins at neXtProt for METAP2: NX_P50579

Explore proteomics data for METAP2 at MOPED 

Post-translational modifications:

  • UniProtKB: Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1
    binding
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P50579

  • METAP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    METAP2 Protein Expression
    REFSEQ proteins: NP_006829.1  
    ENSEMBL proteins: 
     ENSP00000446052   ENSP00000325312   ENSP00000448169   ENSP00000261220   ENSP00000448370  
     ENSP00000449004   ENSP00000448614   ENSP00000450063   ENSP00000447661  
    Reactome Protein details: P50579
    Human Recombinant Protein Products for METAP2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for METAP2 (Methionine Aminopeptidase 2/METAP2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for METAP2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for METAP2
    GenScript Custom Purified and Recombinant Proteins Services for METAP2
    Sino Biological Recombinant Protein for METAP2
    Sino Biological Cell Lysate for METAP2 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for METAP2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA15102683
    GO:0005829cytosol TAS--

    METAP2 for ontologies           About GeneDecksing



    METAP2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    GenScript Custom Superior Antibodies Services for METAP2
    Abcam antibodies for METAP2
    Cloud-Clone Corp. Antibodies for METAP2 
    ThermoFisher Antibodies for METAP2
    LSBio Antibodies in human, mouse, rat for METAP2 

    Assay Products for METAP2: 
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    Cloud-Clone Corp. ELISAs for METAP2 
    Cloud-Clone Corp. CLIAs for METAP2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: Methionyl aminopeptidase 2 
    Aminopeptidases

    5 InterPro protein domains:
     IPR000994 Pept_M24_structural-domain
     IPR002468 Pept_M24A_MAP2
     IPR018349 Pept_M24A_MAP2_BS
     IPR001714 Pept_M24_MAP
     IPR011991 WHTH_DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry P50579

    ProtoNet protein and cluster: P50579

    1 Blocks protein domain: IPB001714 Methionine aminopeptidase-1 signature

    UniProtKB/Swiss-Prot: MAP2_HUMAN, P50579
    Similarity: Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily


    METAP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAP2_HUMAN, P50579
    Function: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is
    often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro,
    Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of
    magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing
    N-terminal Met-Val and Met-Thr sequences in vivo
    Function: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory
    kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis
    Catalytic activity: Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides

         Enzyme Number (IUBMB): EC 3.4.11.181

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004177aminopeptidase activity IDA8858118
    GO:0005515protein binding ----
    GO:0008235metalloexopeptidase activity IDA8858118
    GO:0046872metal ion binding IEA--
         
    METAP2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for METAP2:
     Increased cell number in G1, s  Synthetic lethal with Ras 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Metap2):
     cardiovascular system  cellular  embryogenesis  growth/size  mortality/aging 

    METAP2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Metap2tm1.2Ccr for METAP2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for METAP2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for METAP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for METAP2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for METAP2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat METAP2
    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate METAP2 (see all 42):
    hsa-miR-323-3p hsa-miR-29a hsa-miR-30d hsa-miR-548l hsa-miR-124 hsa-miR-30a hsa-miR-4330 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidMETAP2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: METAP2 (NM_006838)
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                         Customized lentivirus expression plasmids for stable overexpression of METAP2 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METAP2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for METAP2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Visual signal transduction- Rods
    The phototransduction cascade0.54
    Inactivation, recovery and regulation of the phototransduction cascade0.51
    2Visual phototransduction
    Visual phototransduction0.48
    Diseases associated with visual transduction0.47
    3Signaling by GPCR
    Signal Transduction0.55
    4Disease
    Disease
    5Translational Control
    Translational Control

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for METAP2
        Translational Control


    5/6        Reactome Pathways for METAP2 (see all 6)
        Diseases associated with visual transduction
    The phototransduction cascade
    Signal Transduction
    Visual phototransduction
    Disease



    METAP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for METAP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/59 Interacting proteins for METAP2 (P505792, 3 ENSP000003253124) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    S100A4P264473, ENSP000003462944I2D: score=3 STRING: ENSP00000346294
    EIF2S3P410913, ENSP000002530394I2D: score=2 STRING: ENSP00000253039
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0007603phototransduction, visible light TAS--
    GO:0009987cellular process ----
    GO:0016056rhodopsin mediated signaling pathway TAS--
    GO:0016485protein processing IDA8858118

    METAP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    METAP2 for compounds           About GeneDecksing

    EMD Millipore small molecules for METAP2:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for METAP2

    Compounds for METAP2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BestatinAminopeptidase inhibitor[58970-76-6]
    SC 57461ASelective inhibitor of LTA4 hydrolase[423169-68-0]
    CHR 2797Aminopeptidase inhibitor[238750-77-1]

    1 HMDB Compound for METAP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CobaltCo (see all 6)7440-48-4--

    10/16 DrugBank Compounds for METAP2 (see all 16)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Methionine(S)-2-amino-4-(methylthio)butanoic acid (see all 6)63-68-3targetproduct of17114291 16540317 16917013 16823043 16789740
    (2s,3r)-3-Amino-2-Hydroxy-5-(Ethylsulfanyl)Pentanoyl-((S)-(-)-(1-Naphthyl)Ethyl)Amide-- --target--17139284 17016423 10592235
    N'-(2s,3r)-3-Amino-4-Cyclohexyl-2-Hydroxy-Butano-N-(4-Methylphenyl)Hydrazide-- --target--17139284 17016423 10592235
    Ovalicin-- --target--17139284 17016423 10592235
    (E)-(2r,3r,4s,5r)-3,4,5-Trihydroxy-2-Methoxy-8,8-Dimethyl-Non-6-Enoic Acid ((3s,6r)-6-Hydroxy-2-Oxo-Azepan-3-Yl)-Amide-- --target--17139284 17016423
    2-Methyl-2-Propanol-- --target--17139284 17016423
    3,5,6,8-Tetramethyl-N-Methyl Phenanthrolinium-- --target--17139284 17016423
    D-Methionine-- 348-67-4target--17139284 17016423
    (CHLOROACETYL)CARBAMIC ACID (3R,4S,5S,5R)-5-METHOXY-4-[(2R,3R)-2-METHYL-3-(3-METHYL-2-BUTENYL)OXIRANYL]-1-OXASPIRO[2.5]OCT-6-YL ESTER-- --target--10592235
    2-[(PHENYLSULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID-- --target--10592235

    10/11 Novoseek inferred chemical compound relationships for METAP2 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fumagillin 97.2 64 9860943 (7), 10760954 (6), 9177176 (4), 19246010 (3) (see all 24)
    ovalicin 97.2 17 9860943 (3), 14676204 (3), 9224570 (2), 16386852 (1) (see all 6)
    methionine 82.1 70 9177176 (3), 10574784 (3), 15102683 (2), 15760654 (2) (see all 36)
    triazole 45.4 3 15516829 (2)
    benzimidazole 42.4 1 15954858 (1)
    cobalt 41.2 10 15516829 (3), 17636946 (1), 12718546 (1)
    epoxide 30 5 9860943 (2), 9812898 (1)
    vegf 19.4 2 15927358 (1)
    manganese 12.6 7 12718546 (3), 15516829 (1)
    leucine 5.02 2 14741843 (1), 15187415 (1)

    Search CenterWatch for drugs/clinical trials and news about METAP2 / MAP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for METAP2 gene: 
    NM_006838.3  

    Unigene Cluster for METAP2:

    Methionyl aminopeptidase 2
    Hs.444986  [show with all ESTs]
    Unigene Representative Sequence: NM_006838
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000535095 ENST00000323666(uc001tec.3 uc010suv.2 uc001tef.3 uc001tee.3)
    ENST00000546753 ENST00000261220 ENST00000549502 ENST00000553151 ENST00000550777
    ENST00000551840 ENST00000549136 ENST00000549808 ENST00000546478
    miRNA
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    OriGene qPCR primer pairs and template standards for METAP2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METAP2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METAP2

    Additional mRNA sequence: 

    AK055692.1 AK091730.1 AK300836.1 AK315559.1 BC013782.1 BC016008.1 U13261.1 

    18 DOTS entries:

    DT.218617  DT.95322384  DT.218616  DT.101983018  DT.100806161  DT.91771436  DT.100737178  DT.100762758 
    DT.100828121  DT.100828123  DT.100828129  DT.121187177  DT.121187183  DT.121187197  DT.121187202  DT.95322390 
    DT.101962101  DT.121187200 

    24/407 AceView cDNA sequences (see all 407):

    N89839 AA773622 AI753277 CB108884 BM460654 AI473530 BM969507 AA215583 
    AI433319 CR620412 AU142749 BQ775743 T39117 AV702111 BP366001 BM845652 
    AA283030 AI926163 AA605233 CR591800 AI656631 BP376891 BE383020 CA443908 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for METAP2 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                    -     -     -     -                                                         
    SP2:                                -     -                                                         
    SP3:                                      -                                                         
    SP4:                                                                                                
    SP5:                                -     -     -                                                   


    ECgene alternative splicing isoforms for METAP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    METAP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    METAP2 Expression
    About this image


    See METAP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for METAP2

    SOURCE GeneReport for Unigene cluster: Hs.444986
        SABiosciences Expression via Pathway-Focused PCR Arrays including METAP2: 
              Tumor Metastasis in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for METAP2 gene from 10/29 species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Metap21 , 5 methionine aminopeptidase 21, 5 89.19(n)1
    94.98(a)1
      10 (48.69 cM)5
    563071  NM_019648.31  NP_062622.11 
     938584895 
    chicken
    (Gallus gallus)
    Aves METAP21 methionyl aminopeptidase 2 80.77(n)
    87.58(a)
      417912  NM_001006233.1  NP_001006233.1 
    lizard
    (Anolis carolinensis)
    Reptilia METAP26
    methionyl aminopeptidase 2
    71(a)
    1 ↔ 1
    5(30789289-30870940)
    African clawed frog
    (Xenopus laevis)
    Amphibia metap2-prov2 methionine aminopeptidase 2 81.44(n)    BC043889.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb98h062 wufb98h06 75.67(n)   323452  BC055563.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta und1 , 3 methionyl aminopeptidase3
    uninitiated1
    74(a)3
    61.16(n)1
    68.63(a)1
      30C73
    342941  NM_058025.41  NP_477373.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y116A8A.93   -- 73(a)
    (best of 3)
      IV(16848642-16855041)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MAP2(YBL091C)4
    MAP21
    Methionine aminopeptidase, catalyzes the cotranslational more4
    Map2p1
    59.78(n)1
    56.72(a)1
      2(48628-47363)4
    8521871, 4  NP_009462.21  NP_009462.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MAP2B1 methionine aminopeptidase 2B 62.93(n)
    68.26(a)
      825169  NM_001203210.1  NP_001190139.1 
    rice
    (Oryza sativa)
    Liliopsida Os.123222 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.81(n)    AK122063.1 


    ENSEMBL Gene Tree for METAP2 (if available)
    TreeFam Gene Tree for METAP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for METAP2 gene
    ENSG000002574112  PA2G42  
    2 SIMAP similar genes for METAP2 using alignment to 10 protein entries:     MAP2_HUMAN (see all proteins):
    MAP2    PA2G4

    METAP2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for METAP2
    PGOHUM00000240377 PGOHUM00000233201


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1234 SNPs in METAP2 are shown (see all 1234)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs710820261,2
    C--92957000(-) AGAGT-/CTAA  
            
    CTTAG
    1 -- int11Minor allele frequency- CTAA:0.00NA 2
    rs792541321,2
    C,F--95865966(+) TCAGCC/GTAATT 1 -- us2k11Minor allele frequency- G:0.07WA 118
    rs756869771,2
    C,F--95865991(+) AAACTC/GTACCA 1 -- us2k11Minor allele frequency- G:0.07WA 118
    rs732293871,2
    C,F--95866062(+) GCTTTT/AATTAG 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs123117301,2
    C,F,H--95866069(+) TTAGCA/GTCATT 1 -- us2k1 tfbs313Minor allele frequency- G:0.11NS EA NA WA CSA 1487
    rs2002006741,2
    --95866183(+) ATGGA-/TGG   
       ATGAG
    TGGAT
    1 -- us2k10--------
    rs1463419311,2
    --95866195(+) AGTGAA/GTAAGT 1 -- us2k10--------
    rs1132513671,2
    C--95866199(+) AATAAG/ATGAAT 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs122985601,2
    C,F,H--95866257(+) GAAATG/CCTCCA 1 -- us2k16Minor allele frequency- C:0.04NS EA CSA WA 539
    rs1421911491,2
    --95866420(+) TTACCA/CACTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for METAP2 (95867296 - 95909615 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for METAP2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv7234OTHER Inversion18451855

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601870    OMIM disorders: --

    20 diseases for METAP2:    About MalaCards
    microsporidiosis    neurofibromatosis    leishmaniasis    pulmonary fibrosis
    esophageal cancer    malaria    non-hodgkin lymphoma    hodgkin's lymphoma
    colon cancer    osteosarcoma    colorectal cancer    cholangiocarcinoma
    mental retardation    esophagitis    neuroblastoma    rheumatoid arthritis
    arthritis    endotheliitis    lung cancer    adenocarcinoma

    1 disease from the University of Copenhagen DISEASES database for METAP2:
    Microsporidiosis

    METAP2 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for METAP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    microsporidiosis 75.8 2 16917013 (1), 16004378 (1)
    cancer 23.5 14 18264137 (4), 16386852 (2), 16789740 (1), 15523682 (1) (see all 7)
    colon cancer 22.7 4 16386852 (1), 19563408 (1), 15336565 (1), 19703310 (1)
    tumors 11.3 23 18264137 (4), 17450475 (3), 15102683 (2), 16267007 (2) (see all 7)
    colorectal cancer 3.45 1 16386852 (1)

    Genetic Association Database (GAD): METAP2
    Human Genome Epidemiology (HuGE) Navigator: METAP2 (1 document)

    Export disorders for METAP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for METAP2 gene, integrated from 9 sources (see all 118):
    (articles sorted by number of sources associating them with METAP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Eukaryotic methionyl aminopeptidases: two classes of cobalt-dependent enzymes. (PubMed id 7644482)1, 2, 3, 9 Arfin S.M.... Bradshaw R.A. (1995)
    2. Physiologically relevant metal cofactor for methionine aminopeptidase-2 is manganese. (PubMed id 12718546)1, 2, 9 Wang J....Henkin J. (2003)
    3. Structure of human methionine aminopeptidase-2 complexed with fumagillin. (PubMed id 9812898)1, 2, 9 Liu S.... Clardy J. (1998)
    4. Evidence that the human homologue of a rat initiation factor-2 associated protein (p67) is a methionine aminopeptidase. (PubMed id 8858118)1, 3, 9 Li X. and Chang Y.H. (1996)
    5. Molecular cloning of a human complementary DNA encoding an initiation factor 2-associated protein (p67). (PubMed id 7873610)1, 2, 9 Li X. and Chang Y. (1995)
    6. Protein N-terminal processing: substrate specificity of Escherichia coli and human methionine aminopeptidases. (PubMed id 20521764)1, 2 Xiao Q.... Pei D. (2010)
    7. Genetic variation and antioxidant response gene expre ssion in the bronchial airway epithelium of smokers at risk for lung cancer. (PubMed id 20689807)1, 4 Wang X....Bell D.A. (2010)
    8. Human methionine aminopeptidase type 2 in complex with L- and D- methionine. (PubMed id 16540317)2, 7 Nonato M.C.... Clardy J. (2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10988 HGNC: 16672 AceView: METAP2 Ensembl:ENSG00000111142 euGenes: HUgn10988
    ECgene: METAP2 H-InvDB: METAP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for METAP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for METAP2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for METAP2 gene:
    Search GeneIP for patents involving METAP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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