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Aliases for METAP2 Gene

Aliases for METAP2 Gene

  • Methionyl Aminopeptidase 2 2 3 5
  • Initiation Factor 2-Associated 67 KDa Glycoprotein 3 4
  • Peptidase M 2 4
  • P67eIF2 3 4
  • MNPEP 3 4
  • Testicular Tissue Protein Li 17 3
  • EIF-2-Associated P67 Homolog 3
  • Methionine Aminopeptidase 2 3
  • Peptidase M 2 3
  • EC 3.4.11.18 4
  • MetAP 2 4
  • MAP 2 4
  • MAP2 3
  • P67 4

External Ids for METAP2 Gene

Previous GeneCards Identifiers for METAP2 Gene

  • GC12M095311
  • GC12P096231
  • GC12P095800
  • GC12P094370
  • GC12P092936

Summaries for METAP2 Gene

Entrez Gene Summary for METAP2 Gene

  • The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of this gene is located on chromosome 2. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for METAP2 Gene

METAP2 (Methionyl Aminopeptidase 2) is a Protein Coding gene. Diseases associated with METAP2 include Microsporidiosis and Pilocytic Astrocytoma. Among its related pathways are Metabolism of fat-soluble vitamins and Signaling by GPCR. GO annotations related to this gene include poly(A) RNA binding and aminopeptidase activity. An important paralog of this gene is PA2G4.

UniProtKB/Swiss-Prot for METAP2 Gene

  • Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.

  • Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.

Tocris Summary for METAP2 Gene

Gene Wiki entry for METAP2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METAP2 Gene

Genomics for METAP2 Gene

Regulatory Elements for METAP2 Gene

Enhancers for METAP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G096419 1.9 FANTOM5 Ensembl ENCODE dbSUPER 19.5 +952.4 952360 12.6 PKNOX1 ZNF493 ZFP64 SIN3A BRCA1 GTF3C2 ZNF121 GATA2 KLF7 ZNF548 ELK3 METAP2 USP44 CDK17 CFAP54 RN7SKP11 GC12P096416
GH12G095550 1.5 Ensembl ENCODE dbSUPER 19.6 +78.1 78103 2.4 ZNF493 ZFP64 ETS1 ZNF121 GLIS2 KLF7 ZNF202 REST ZNF623 ZNF518A USP44 METAP2 ELK3 PGAM1P5 ENSG00000212448
GH12G096033 1.4 ENCODE dbSUPER 19.5 +561.7 561719 2.9 CREB3L1 ZFP64 DMAP1 FEZF1 YY1 ZNF143 ZNF548 ZNF263 SP3 TBX21 ELK3 HAL LOC102723340 METAP2 USP44 AMDHD1 TRD-GTC2-8 ENSG00000257715
GH12G095211 2 FANTOM5 Ensembl ENCODE dbSUPER 13.3 -257.3 -257323 8.7 MLX CREB3L1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 METAP2 FGD6 GC12P095210
GH12G095941 1.1 ENCODE 19.5 +469.6 469647 2.4 PKNOX1 ZFP64 SIN3A ARID4B FEZF1 DMAP1 ZNF2 YY1 CBX5 ZNF263 AMDHD1 ELK3 METAP2 USP44 HAL CCDC38 GC12P095914
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around METAP2 on UCSC Golden Path with GeneCards custom track

Promoters for METAP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000055885 780 2601 HDGF MLX ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143

Genomic Location for METAP2 Gene

Chromosome:
12
Start:
95,473,520 bp from pter
End:
95,515,839 bp from pter
Size:
42,320 bases
Orientation:
Plus strand

Genomic View for METAP2 Gene

Genes around METAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METAP2 Gene

Proteins for METAP2 Gene

  • Protein details for METAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50579-MAP2_HUMAN
    Recommended name:
    Methionine aminopeptidase 2
    Protein Accession:
    P50579
    Secondary Accessions:
    • B2RDI8
    • B4DUX5
    • G3XA91
    • Q8NB11

    Protein attributes for METAP2 Gene

    Size:
    478 amino acids
    Molecular mass:
    52892 Da
    Cofactor:
    Name=Co(2+); Xref=ChEBI:CHEBI:48828; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    • Interacts strongly with the eIF-2 gamma-subunit EIF2S3 (By similarity). Binds EIF2S1 at low magnesium concentrations.

    Three dimensional structures from OCA and Proteopedia for METAP2 Gene

    Alternative splice isoforms for METAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for METAP2 Gene

Post-translational modifications for METAP2 Gene

  • Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.
  • Ubiquitination at posLast=289289 and posLast=427427
  • Glycosylation at posLast=6060 and Ser63
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for METAP2 (Methionine Aminopeptidase 2/METAP2)
  • Cell Signaling Technology (CST) Antibodies for METAP2 (METAP2)

No data available for DME Specific Peptides for METAP2 Gene

Domains & Families for METAP2 Gene

Gene Families for METAP2 Gene

Suggested Antigen Peptide Sequences for METAP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P50579

UniProtKB/Swiss-Prot:

MAP2_HUMAN :
  • Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
Family:
  • Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
genes like me logo Genes that share domains with METAP2: view

Function for METAP2 Gene

Molecular function for METAP2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
UniProtKB/Swiss-Prot Function:
Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.
UniProtKB/Swiss-Prot Function:
Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.

Enzyme Numbers (IUBMB) for METAP2 Gene

Gene Ontology (GO) - Molecular Function for METAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0004177 aminopeptidase activity IEA,TAS --
GO:0008233 peptidase activity IEA --
GO:0008235 metalloexopeptidase activity IEA,IDA 8858118
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with METAP2: view
genes like me logo Genes that share phenotypes with METAP2: view

Animal Models for METAP2 Gene

MGI Knock Outs for METAP2:

Animal Model Products

  • Taconic Biosciences Mouse Models for METAP2

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for METAP2 Gene

Localization for METAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for METAP2 Gene

Cytoplasm. Note=About 30% of expressed METAP2 associates with polysomes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METAP2 gene
Compartment Confidence
plasma membrane 5
cytosol 5
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for METAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 15102683
GO:0005829 cytosol IDA,TAS --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with METAP2: view

Pathways & Interactions for METAP2 Gene

genes like me logo Genes that share pathways with METAP2: view

Pathways by source for METAP2 Gene

Gene Ontology (GO) - Biological Process for METAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0016485 protein processing IDA 8858118
GO:0018206 peptidyl-methionine modification IDA 8858118
GO:0022400 regulation of rhodopsin mediated signaling pathway TAS --
GO:0031365 N-terminal protein amino acid modification IDA 8858118
genes like me logo Genes that share ontologies with METAP2: view

No data available for SIGNOR curated interactions for METAP2 Gene

Drugs & Compounds for METAP2 Gene

(29) Drugs for METAP2 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Methionine Approved Nutra Target, product of 0
Nitroxoline Approved Pharma Target, inhibitor 0
Fumagillin Experimental Pharma Target, ligand Antibiotic and antiangiogenic agent 0
Ovalicin Experimental Pharma Target 0
(2s,3r)-3-Amino-2-Hydroxy-5-(Ethylsulfanyl)Pentanoyl-((S)-(-)-(1-Naphthyl)Ethyl)Amide Experimental Pharma Target 0

(6) Additional Compounds for METAP2 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Methylpropan-2-ol
  • 1,1-Dimethylethanol
  • 2-Methyl N-propan-2-ol
  • 2-Methyl-2-Propanol
  • 2-Methylpropan-2-ol
  • Alcohol, tert-butyl
75-65-0
CHR 2797
238750-77-1
HFI 142
332164-34-8

(4) Tocris Compounds for METAP2 Gene

Compound Action Cas Number
Bestatin Aminopeptidase inhibitor 58970-76-6
CHR 2797 Aminopeptidase inhibitor 238750-77-1
HFI 142 Insulin-regulated aminopeptidase (IRAP) inhibitor 332164-34-8
SC 57461A Selective inhibitor of LTA4 hydrolase 423169-68-0

(1) ApexBio Compounds for METAP2 Gene

Compound Action Cas Number
Fumagillin Antibiotic and antiangiogenic agent 23110-15-8
genes like me logo Genes that share compounds with METAP2: view

Drug Products

Transcripts for METAP2 Gene

Unigene Clusters for METAP2 Gene

Methionyl aminopeptidase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for METAP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - -
SP2: - -
SP3: -
SP4:
SP5: - - -
SP6:

Relevant External Links for METAP2 Gene

GeneLoc Exon Structure for
METAP2
ECgene alternative splicing isoforms for
METAP2

Expression for METAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for METAP2 Gene

Protein differential expression in normal tissues from HIPED for METAP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.8) and Lavage (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for METAP2 Gene



Protein tissue co-expression partners for METAP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of METAP2 Gene:

METAP2

SOURCE GeneReport for Unigene cluster for METAP2 Gene:

Hs.444986

Evidence on tissue expression from TISSUES for METAP2 Gene

  • Nervous system(4.8)
  • Liver(4.5)
  • Heart(4.3)
  • Intestine(4.3)
genes like me logo Genes that share expression patterns with METAP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METAP2 Gene

Orthologs for METAP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METAP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METAP2 34 35
  • 99.72 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia METAP2 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia METAP2 34 35
  • 95.32 (n)
dog
(Canis familiaris)
Mammalia METAP2 34 35
  • 94.97 (n)
rat
(Rattus norvegicus)
Mammalia Metap2 34
  • 89.2 (n)
mouse
(Mus musculus)
Mammalia Metap2 34 16 35
  • 89.19 (n)
oppossum
(Monodelphis domestica)
Mammalia METAP2 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves METAP2 34 35
  • 80.56 (n)
lizard
(Anolis carolinensis)
Reptilia METAP2 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia metap2 34
  • 77.97 (n)
Str.8946 34
African clawed frog
(Xenopus laevis)
Amphibia metap2-prov 34
zebrafish
(Danio rerio)
Actinopterygii metap2a 34 35
  • 75.45 (n)
wufb98h06 34
fruit fly
(Drosophila melanogaster)
Insecta und 36 34 35
  • 63.94 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008345 34
  • 61.67 (n)
worm
(Caenorhabditis elegans)
Secernentea Y116A8A.9 36
  • 73 (a)
F53B6.5 36 35
  • 67 (a)
T27A8.3 36 35
  • 66 (a)
map-2 35
  • 55 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAP2 34 35 37
  • 61.08 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E06887g 34
  • 59.51 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL283W 34
  • 54.61 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons MAP2B 34
  • 65.01 (n)
soybean
(Glycine max)
eudicotyledons Gma.4154 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9148 34
rice
(Oryza sativa)
Liliopsida Os12g0628500 34
  • 65.76 (n)
Os.12322 34
barley
(Hordeum vulgare)
Liliopsida Hv.1251 34
wheat
(Triticum aestivum)
Liliopsida Ta.2490 34
corn
(Zea mays)
Liliopsida Zm.4989 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11326 35
  • 70 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes fma2 34
  • 62.22 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04306 34
  • 56.07 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4546 34
Species where no ortholog for METAP2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for METAP2 Gene

ENSEMBL:
Gene Tree for METAP2 (if available)
TreeFam:
Gene Tree for METAP2 (if available)

Paralogs for METAP2 Gene

Paralogs for METAP2 Gene

Pseudogenes.org Pseudogenes for METAP2 Gene

genes like me logo Genes that share paralogs with METAP2: view

Variants for METAP2 Gene

Sequence variations from dbSNP and Humsavar for METAP2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000034352 -- 95,492,352(+) ATATA(A/G)GAAAA intron-variant
rs1000056014 -- 95,478,811(+) AAGGA(A/G)CTATT intron-variant
rs1000142329 -- 95,502,381(+) AGTTA(A/G)CACTT intron-variant
rs1000183117 -- 95,507,617(+) AGGAT(C/T)TTCTT intron-variant
rs1000195120 -- 95,475,147(+) CTGCA(C/G)AAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for METAP2 Gene

Variant ID Type Subtype PubMed ID
nsv1119977 CNV deletion 24896259
nsv7234 OTHER inversion 18451855
nsv976647 CNV duplication 23825009

Variation tolerance for METAP2 Gene

Residual Variation Intolerance Score: 57.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.04; 37.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for METAP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
METAP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METAP2 Gene

Disorders for METAP2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for METAP2 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
microsporidiosis
  • infection by microspora
pilocytic astrocytoma
  • grade i astrocytic tumor
obesity
  • obesity, association with
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for METAP2

Genetic Association Database (GAD)
METAP2
Human Genome Epidemiology (HuGE) Navigator
METAP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
METAP2
genes like me logo Genes that share disorders with METAP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for METAP2 Gene

Publications for METAP2 Gene

  1. Eukaryotic methionyl aminopeptidases: two classes of cobalt-dependent enzymes. (PMID: 7644482) Arfin S.M. … Bradshaw R.A. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 22 64
  2. Physiologically relevant metal cofactor for methionine aminopeptidase-2 is manganese. (PMID: 12718546) Wang J. … Henkin J. (Biochemistry 2003) 3 4 22 64
  3. Structure of human methionine aminopeptidase-2 complexed with fumagillin. (PMID: 9812898) Liu S. … Clardy J. (Science 1998) 3 4 22 64
  4. Evidence that the human homologue of a rat initiation factor-2 associated protein (p67) is a methionine aminopeptidase. (PMID: 8858118) Li X. … Chang Y.H. (Biochem. Biophys. Res. Commun. 1996) 2 3 22 64
  5. Molecular cloning of a human complementary DNA encoding an initiation factor 2-associated protein (p67). (PMID: 7873610) Li X. … Chang Y. (Biochim. Biophys. Acta 1995) 3 4 22 64

Products for METAP2 Gene

Sources for METAP2 Gene

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