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Aliases for METAP2 Gene

Aliases for METAP2 Gene

  • Methionyl Aminopeptidase 2 2 3
  • P67 3 4 6
  • Initiation Factor 2-Associated 67 KDa Glycoprotein 3 4
  • Peptidase M 2 4
  • MetAP 2 3 4
  • P67eIF2 3 4
  • MAP 2 3 4
  • MNPEP 3 4
  • EIF-2-Associated P67 Homolog 3
  • Methionine Aminopeptidase 2 3
  • Peptidase M 2 3
  • EC 3.4.11.18 4
  • MAP2 3

External Ids for METAP2 Gene

Summaries for METAP2 Gene

Entrez Gene Summary for METAP2 Gene

  • This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2. [provided by RefSeq, Jul 2008]

GeneCards Summary for METAP2 Gene

METAP2 (Methionyl Aminopeptidase 2) is a Protein Coding gene. Diseases associated with METAP2 include microsporidiosis. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include aminopeptidase activity and metalloexopeptidase activity. An important paralog of this gene is ENSG00000257411.

UniProtKB/Swiss-Prot for METAP2 Gene

  • Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo

  • Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis

Gene Wiki entry for METAP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METAP2 Gene

Genomics for METAP2 Gene

Genomic Location for METAP2 Gene

Start:
95,473,520 bp from pter
End:
95,515,839 bp from pter
Size:
42,320 bases
Orientation:
Plus strand

Genomic View for METAP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for METAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METAP2 Gene

Regulatory Elements for METAP2 Gene

Proteins for METAP2 Gene

  • Protein details for METAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50579-MAP2_HUMAN
    Recommended name:
    Methionine aminopeptidase 2
    Protein Accession:
    P50579
    Secondary Accessions:
    • B2RDI8
    • B4DUX5
    • G3XA91
    • Q8NB11

    Protein attributes for METAP2 Gene

    Size:
    478 amino acids
    Molecular mass:
    52892 Da
    Cofactor:
    Name=Co(2+); Xref=ChEBI:CHEBI:48828; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Note=Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site. Also manganese has been proposed to be the physiological cofactor for human METAP2.;
    Quaternary structure:
    • Interacts strongly with the eIF-2 gamma-subunit EIF2S3 (By similarity). Binds EIF2S1 at low magnesium concentrations.

    Three dimensional structures from OCA and Proteopedia for METAP2 Gene

    Alternative splice isoforms for METAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for METAP2 Gene

Proteomics data for METAP2 Gene at MOPED

Post-translational modifications for METAP2 Gene

  • Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys289 and Lys427
  • Glycosylation at Ser60 and Ser63

Other Protein References for METAP2 Gene

No data available for DME Specific Peptides for METAP2 Gene

Domains for METAP2 Gene

Gene Families for METAP2 Gene

UniProtKB/Swiss-Prot:

MAP2_HUMAN
Family:
  • Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.:
    • P50579
genes like me logo Genes that share domains with METAP2: view

Function for METAP2 Gene

Molecular function for METAP2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
UniProtKB/Swiss-Prot Function: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo
UniProtKB/Swiss-Prot Function: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis

Enzyme Numbers (IUBMB) for METAP2 Gene

Gene Ontology (GO) - Molecular Function for METAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004177 aminopeptidase activity IDA 8858118
GO:0005515 protein binding --
GO:0008235 metalloexopeptidase activity IDA 8858118
GO:0016787 hydrolase activity --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with METAP2: view
genes like me logo Genes that share phenotypes with METAP2: view

Animal Models for METAP2 Gene

MGI Knock Outs for METAP2:

miRNA for METAP2 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for METAP2 Gene

Localization for METAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for METAP2 Gene

Cytoplasm. Note=About 30% of expressed METAP2 associates with polysomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for METAP2 Gene COMPARTMENTS Subcellular localization image for METAP2 gene
Compartment Confidence
cytosol 2
nucleus 2
chloroplast 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for METAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with METAP2: view

Pathways for METAP2 Gene

genes like me logo Genes that share pathways with METAP2: view

Pathways by source for METAP2 Gene

1 Qiagen pathway for METAP2 Gene
2 Cell Signaling Technology pathways for METAP2 Gene
3 BioSystems pathways for METAP2 Gene

Gene Ontology (GO) - Biological Process for METAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis --
GO:0007603 phototransduction, visible light TAS --
GO:0008152 metabolic process --
GO:0016056 rhodopsin mediated signaling pathway TAS --
GO:0016485 protein processing IDA 8858118
genes like me logo Genes that share ontologies with METAP2: view

Compounds for METAP2 Gene

(4) ApexBio Compounds for METAP2 Gene

Compound Action Cas Number
Bestatin Specific inhibitor of aminopeptidase B and leucine aminopeptidase [58970-76-6]
Fumagillin inhibits methionine aminopeptidase-2. [23110-15-8]
SC 57461A Potent and selective inhibitor of LTA4 hydrolase. [423169-68-0]
Tosedostat (CHR2797) aminopeptidase inhibitor for LAP, PuSA and Aminopeptidase N. [238750-77-1]

(3) Tocris Compounds for METAP2 Gene

Compound Action Cas Number
Bestatin Aminopeptidase inhibitor [58970-76-6]
CHR 2797 Aminopeptidase inhibitor [238750-77-1]
SC 57461A Selective inhibitor of LTA4 hydrolase [423169-68-0]

(1) HMDB Compounds for METAP2 Gene

Compound Synonyms Cas Number PubMed IDs
Cobalt
  • Co
7440-48-4

(11) Novoseek inferred chemical compound relationships for METAP2 Gene

Compound -log(P) Hits PubMed IDs
fumagillin 97.2 48
ovalicin 97.2 11
methionine 82.1 48
triazole 45.4 2
benzimidazole 42.4 1
genes like me logo Genes that share compounds with METAP2: view

Transcripts for METAP2 Gene

Unigene Clusters for METAP2 Gene

Methionyl aminopeptidase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for METAP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - -
SP2: - -
SP3: -
SP4:
SP5: - - -
SP6:

Relevant External Links for METAP2 Gene

GeneLoc Exon Structure for
METAP2
ECgene alternative splicing isoforms for
METAP2

Expression for METAP2 Gene

mRNA expression in normal human tissues for METAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for METAP2 Gene

SOURCE GeneReport for Unigene cluster for METAP2 Gene Hs.444986

genes like me logo Genes that share expressions with METAP2: view

Orthologs for METAP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METAP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METAP2 36
  • 99.72 (n)
  • 100 (a)
METAP2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia METAP2 36
  • 95.32 (n)
  • 96.65 (a)
METAP2 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia METAP2 36
  • 94.97 (n)
  • 98.11 (a)
METAP2 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Metap2 36
  • 89.19 (n)
  • 94.98 (a)
Metap2 16
Metap2 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia METAP2 37
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia METAP2 37
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Metap2 36
  • 89.2 (n)
  • 94.82 (a)
chicken
(Gallus gallus)
Aves METAP2 36
  • 80.56 (n)
  • 87.37 (a)
METAP2 37
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia METAP2 37
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia metap2-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia metap2 36
  • 77.97 (n)
  • 86.52 (a)
Str.8946 36
zebrafish
(Danio rerio)
Actinopterygii metap2a 36
  • 75.45 (n)
  • 90.05 (a)
metap2a 37
  • 80 (a)
OneToOne
wufb98h06 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008345 36
  • 61.67 (n)
  • 75 (a)
fruit fly
(Drosophila melanogaster)
Insecta und 36
  • 63.94 (n)
  • 74.93 (a)
und 37
  • 66 (a)
OneToOne
und 38
  • 74 (a)
worm
(Caenorhabditis elegans)
Secernentea F53B6.5 37
  • 50 (a)
OneToMany
map-2 37
  • 55 (a)
OneToMany
T27A8.3 37
  • 49 (a)
OneToMany
T27A8.3 38
  • 66 (a)
F53B6.5 38
  • 67 (a)
Y116A8A.9 38
  • 73 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL283W 36
  • 54.61 (n)
  • 60.49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAP2 36
  • 61.08 (n)
  • 60.51 (a)
MAP2 37
  • 53 (a)
OneToMany
MAP2 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E06887g 36
  • 59.51 (n)
  • 61.3 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9148 36
soybean
(Glycine max)
eudicotyledons Gma.4154 36
thale cress
(Arabidopsis thaliana)
eudicotyledons MAP2B 36
  • 65.01 (n)
  • 73.48 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.1251 36
corn
(Zea mays)
Liliopsida Zm.4989 36
rice
(Oryza sativa)
Liliopsida Os.12322 36
Os12g0628500 36
  • 65.76 (n)
  • 72.21 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.2490 36
bread mold
(Neurospora crassa)
Ascomycetes NCU04306 36
  • 56.07 (n)
  • 59.48 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes fma2 36
  • 62.22 (n)
  • 63.76 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4546 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11326 37
  • 70 (a)
OneToOne
Species with no ortholog for METAP2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for METAP2 Gene

ENSEMBL:
Gene Tree for METAP2 (if available)
TreeFam:
Gene Tree for METAP2 (if available)

Paralogs for METAP2 Gene

Paralogs for METAP2 Gene

Selected SIMAP similar genes for METAP2 Gene using alignment to 11 proteins:

Pseudogenes.org Pseudogenes for METAP2 Gene

genes like me logo Genes that share paralogs with METAP2: view

Variants for METAP2 Gene

Sequence variations from dbSNP and Humsavar for METAP2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs167286 -- 95,474,646(-) CTGCG(A/C)ACAAT intron-variant
rs188526 -- 95,501,444(-) caccg(C/T)gcgcg intron-variant
rs301007 -- 95,473,074(-) CAATA(C/G)TAATA upstream-variant-2KB
rs301008 -- 95,473,920(+) CGATT(G/T)GCTTC upstream-variant-2KB
rs301009 -- 95,475,096(-) ATAAT(A/G)TCCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for METAP2 Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER Inversion 18451855

Relevant External Links for METAP2 Gene

HapMap Linkage Disequilibrium report
METAP2

Disorders for METAP2 Gene

(1) MalaCards Diseases for METAP2 Gene

Search for METAP2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for METAP2 Gene

(5) Novoseek inferred disease relationships for METAP2 Gene

Disease -log(P) Hits PubMed IDs
microsporidiosis 75.8 2
cancer 23.5 11
colon cancer 22.7 4
tumors 11.3 14
colorectal cancer 3.45 1

Relevant External Links for METAP2

Genetic Association Database (GAD)
METAP2
Human Genome Epidemiology (HuGE) Navigator
METAP2
genes like me logo Genes that share disorders with METAP2: view

No data available for UniProtKB/Swiss-Prot for METAP2 Gene

Publications for METAP2 Gene

  1. Eukaryotic methionyl aminopeptidases: two classes of cobalt-dependent enzymes. (PMID: 7644482) Arfin S.M. … Bradshaw R.A. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 23
  2. Molecular cloning of a human complementary DNA encoding an initiation factor 2-associated protein (p67). (PMID: 7873610) Li X. … Chang Y. (Biochim. Biophys. Acta 1995) 3 4 23
  3. Evidence that the human homologue of a rat initiation factor-2 associated protein (p67) is a methionine aminopeptidase. (PMID: 8858118) Li X. … Chang Y.H. (Biochem. Biophys. Res. Commun. 1996) 2 3 23
  4. Structure of human methionine aminopeptidase-2 complexed with fumagillin. (PMID: 9812898) Liu S. … Clardy J. (Science 1998) 3 4 23
  5. Physiologically relevant metal cofactor for methionine aminopeptidase-2 is manganese. (PMID: 12718546) Wang J. … Henkin J. (Biochemistry 2003) 3 4 23

Products for METAP2 Gene

Sources for METAP2 Gene

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