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Aliases for METAP2 Gene

Aliases for METAP2 Gene

  • Methionyl Aminopeptidase 2 2 3 5
  • Initiation Factor 2-Associated 67 KDa Glycoprotein 3 4
  • Peptidase M 2 4
  • P67eIF2 3 4
  • MNPEP 3 4
  • Testicular Tissue Protein Li 17 3
  • EIF-2-Associated P67 Homolog 3
  • Peptidase M 2 3
  • EC 3.4.11.18 4
  • MetAP 2 4
  • MAP 2 4
  • MAP2 3
  • P67 4

External Ids for METAP2 Gene

Previous GeneCards Identifiers for METAP2 Gene

  • GC12M095311
  • GC12P096231
  • GC12P095800
  • GC12P094370
  • GC12P092936

Summaries for METAP2 Gene

Entrez Gene Summary for METAP2 Gene

  • The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of this gene is located on chromosome 2. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for METAP2 Gene

METAP2 (Methionyl Aminopeptidase 2) is a Protein Coding gene. Diseases associated with METAP2 include microsporidiosis and pilocytic astrocytoma. Among its related pathways are Signaling by GPCR and Metabolism of fat-soluble vitamins. GO annotations related to this gene include poly(A) RNA binding and aminopeptidase activity. An important paralog of this gene is ENSG00000257411.

UniProtKB/Swiss-Prot for METAP2 Gene

  • Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.

  • Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.

Tocris Summary for METAP2 Gene

Gene Wiki entry for METAP2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METAP2 Gene

Genomics for METAP2 Gene

Regulatory Elements for METAP2 Gene

Promoters for METAP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around METAP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for METAP2 Gene

Chromosome:
12
Start:
95,473,520 bp from pter
End:
95,515,839 bp from pter
Size:
42,320 bases
Orientation:
Plus strand

Genomic View for METAP2 Gene

Genes around METAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METAP2 Gene

Proteins for METAP2 Gene

  • Protein details for METAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50579-MAP2_HUMAN
    Recommended name:
    Methionine aminopeptidase 2
    Protein Accession:
    P50579
    Secondary Accessions:
    • B2RDI8
    • B4DUX5
    • G3XA91
    • Q8NB11

    Protein attributes for METAP2 Gene

    Size:
    478 amino acids
    Molecular mass:
    52892 Da
    Cofactor:
    Name=Co(2+); Xref=ChEBI:CHEBI:48828; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    • Interacts strongly with the eIF-2 gamma-subunit EIF2S3 (By similarity). Binds EIF2S1 at low magnesium concentrations.

    Three dimensional structures from OCA and Proteopedia for METAP2 Gene

    Alternative splice isoforms for METAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for METAP2 Gene

Proteomics data for METAP2 Gene at MOPED

Post-translational modifications for METAP2 Gene

  • Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.
  • Ubiquitination at Lys 289 and Lys 427
  • Glycosylation at Ser 60 and Ser 63
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for METAP2 (Methionine Aminopeptidase 2/METAP2)
  • Cell Signaling Technology (CST) Antibodies for METAP2 (METAP2)

Protein Products

  • Enzo Life Sciences proteins for METAP2

No data available for DME Specific Peptides for METAP2 Gene

Domains & Families for METAP2 Gene

Gene Families for METAP2 Gene

Suggested Antigen Peptide Sequences for METAP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P50579

UniProtKB/Swiss-Prot:

MAP2_HUMAN :
  • Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
Family:
  • Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
genes like me logo Genes that share domains with METAP2: view

Function for METAP2 Gene

Molecular function for METAP2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
UniProtKB/Swiss-Prot Function:
Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.
UniProtKB/Swiss-Prot Function:
Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.

Enzyme Numbers (IUBMB) for METAP2 Gene

Gene Ontology (GO) - Molecular Function for METAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070006 metalloaminopeptidase activity IEA --
genes like me logo Genes that share ontologies with METAP2: view
genes like me logo Genes that share phenotypes with METAP2: view

Animal Models for METAP2 Gene

MGI Knock Outs for METAP2:

Animal Model Products

  • Taconic Biosciences Mouse Models for METAP2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for METAP2 Gene

Localization for METAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for METAP2 Gene

Cytoplasm. Note=About 30% of expressed METAP2 associates with polysomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for METAP2 Gene COMPARTMENTS Subcellular localization image for METAP2 gene
Compartment Confidence
cytosol 5
plasma membrane 5
nucleus 2
cytoskeleton 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for METAP2 Gene

Pathways & Interactions for METAP2 Gene

genes like me logo Genes that share pathways with METAP2: view

Pathways by source for METAP2 Gene

Gene Ontology (GO) - Biological Process for METAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007603 phototransduction, visible light TAS --
GO:0016056 rhodopsin mediated signaling pathway TAS --
GO:0018206 peptidyl-methionine modification IDA 8858118
GO:0022400 regulation of rhodopsin mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with METAP2: view

No data available for SIGNOR curated interactions for METAP2 Gene

Drugs & Compounds for METAP2 Gene

(29) Drugs for METAP2 Gene - From: Novoseek, DrugBank, HMDB, DGIdb, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Methionine Approved Nutra Target, product of 0
Nitroxoline Approved Pharma Target, inhibitor 0
Captopril Approved Pharma Inhibition, Inhibitor ACE inhibitor, ACE inhibitor; also inhibits LTA4 hydrolase 29
Fumagillin Experimental Pharma Target, ligand Methionine aminopeptidase-2 inhibitor; antiangiogenic 0
Ovalicin Experimental Pharma Target 0

(5) Additional Compounds for METAP2 Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
CHR 2797
238750-77-1
SC 57461A
423169-68-0

(5) Tocris Compounds for METAP2 Gene

Compound Action Cas Number
Bestatin Aminopeptidase inhibitor 58970-76-6
Captopril ACE inhibitor; also inhibits LTA4 hydrolase 62571-86-2
CHR 2797 Aminopeptidase inhibitor 238750-77-1
Fumagillin Methionine aminopeptidase-2 inhibitor; antiangiogenic 23110-15-8
SC 57461A Selective inhibitor of LTA4 hydrolase 423169-68-0
genes like me logo Genes that share compounds with METAP2: view

Transcripts for METAP2 Gene

Unigene Clusters for METAP2 Gene

Methionyl aminopeptidase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for METAP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - -
SP2: - -
SP3: -
SP4:
SP5: - - -
SP6:

Relevant External Links for METAP2 Gene

GeneLoc Exon Structure for
METAP2
ECgene alternative splicing isoforms for
METAP2

Expression for METAP2 Gene

mRNA expression in normal human tissues for METAP2 Gene

Protein differential expression in normal tissues from HIPED for METAP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.8) and Lavage (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for METAP2 Gene



SOURCE GeneReport for Unigene cluster for METAP2 Gene Hs.444986

genes like me logo Genes that share expression patterns with METAP2: view

Protein tissue co-expression partners for METAP2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for METAP2 Gene

Orthologs for METAP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METAP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia METAP2 35
  • 95.32 (n)
  • 96.65 (a)
METAP2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia METAP2 35
  • 94.97 (n)
  • 98.11 (a)
METAP2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Metap2 35
  • 89.19 (n)
  • 94.98 (a)
Metap2 16
Metap2 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia METAP2 35
  • 99.72 (n)
  • 100 (a)
METAP2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Metap2 35
  • 89.2 (n)
  • 94.82 (a)
oppossum
(Monodelphis domestica)
Mammalia METAP2 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia METAP2 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves METAP2 35
  • 80.56 (n)
  • 87.37 (a)
METAP2 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia METAP2 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia metap2 35
  • 77.97 (n)
  • 86.52 (a)
Str.8946 35
African clawed frog
(Xenopus laevis)
Amphibia metap2-prov 35
zebrafish
(Danio rerio)
Actinopterygii metap2a 35
  • 75.45 (n)
  • 90.05 (a)
wufb98h06 35
metap2a 36
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta und 37
  • 74 (a)
und 35
  • 63.94 (n)
  • 74.93 (a)
und 36
  • 66 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008345 35
  • 61.67 (n)
  • 75 (a)
worm
(Caenorhabditis elegans)
Secernentea F53B6.5 37
  • 67 (a)
T27A8.3 37
  • 66 (a)
Y116A8A.9 37
  • 73 (a)
F53B6.5 36
  • 50 (a)
OneToMany
map-2 36
  • 55 (a)
OneToMany
T27A8.3 36
  • 49 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL283W 35
  • 54.61 (n)
  • 60.49 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E06887g 35
  • 59.51 (n)
  • 61.3 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAP2 35
  • 61.08 (n)
  • 60.51 (a)
MAP2 36
  • 53 (a)
OneToMany
MAP2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons MAP2B 35
  • 65.01 (n)
  • 73.48 (a)
soybean
(Glycine max)
eudicotyledons Gma.4154 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9148 35
barley
(Hordeum vulgare)
Liliopsida Hv.1251 35
rice
(Oryza sativa)
Liliopsida Os.12322 35
Os12g0628500 35
  • 65.76 (n)
  • 72.21 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.2490 35
corn
(Zea mays)
Liliopsida Zm.4989 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4546 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04306 35
  • 56.07 (n)
  • 59.48 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes fma2 35
  • 62.22 (n)
  • 63.76 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11326 36
  • 70 (a)
OneToOne
Species with no ortholog for METAP2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for METAP2 Gene

ENSEMBL:
Gene Tree for METAP2 (if available)
TreeFam:
Gene Tree for METAP2 (if available)

Paralogs for METAP2 Gene

Paralogs for METAP2 Gene

Pseudogenes.org Pseudogenes for METAP2 Gene

genes like me logo Genes that share paralogs with METAP2: view

Variants for METAP2 Gene

Sequence variations from dbSNP and Humsavar for METAP2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs188526 -- 95,501,444(-) caccg(C/T)gcgcg intron-variant
rs301007 -- 95,473,074(-) CAATA(C/G)TAATA upstream-variant-2KB
rs301008 -- 95,473,920(+) CGATT(G/T)GCTTC upstream-variant-2KB
rs301009 -- 95,475,096(-) ATAAT(A/G)TCCAA intron-variant
rs301010 -- 95,476,378(-) TGTGC(C/T)ACCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for METAP2 Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER Inversion 18451855

Variation tolerance for METAP2 Gene

Residual Variation Intolerance Score: 57.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.04; 37.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for METAP2 Gene

HapMap Linkage Disequilibrium report
METAP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METAP2 Gene

Disorders for METAP2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for METAP2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
microsporidiosis
  • infection by microspora
pilocytic astrocytoma
  • grade i astrocytic tumor
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for METAP2

Genetic Association Database (GAD)
METAP2
Human Genome Epidemiology (HuGE) Navigator
METAP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
METAP2
genes like me logo Genes that share disorders with METAP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for METAP2 Gene

Publications for METAP2 Gene

  1. Eukaryotic methionyl aminopeptidases: two classes of cobalt-dependent enzymes. (PMID: 7644482) Arfin S.M. … Bradshaw R.A. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 23 67
  2. Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding. (PMID: 16789740) Sheppard G.S. … Bell R.L. (J. Med. Chem. 2006) 23 25 26
  3. System for expression of microsporidian methionine amino peptidase type 2 (MetAP2) in the yeast Saccharomyces cerevisiae. (PMID: 16917013) Upadhya R. … Weiss L.M. (Antimicrob. Agents Chemother. 2006) 23 25 26
  4. Evidence that the human homologue of a rat initiation factor-2 associated protein (p67) is a methionine aminopeptidase. (PMID: 8858118) Li X. … Chang Y.H. (Biochem. Biophys. Res. Commun. 1996) 2 3 23
  5. NC2213: a novel methionine aminopeptidase 2 inhibitor in human colon cancer HT29 cells. (PMID: 19703310) Selvakumar P. … Sharma R.K. (Mol. Cancer 2009) 3 23

Products for METAP2 Gene

Sources for METAP2 Gene

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