METAP2 Gene
protein-coding GIFtS: 64
GCID: GC12P095800
|
|
methionyl aminopeptidase 2
| |
Aliases
for METAP2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Methionyl Aminopeptidase 21 2 | | MAP 22 3 | | MNPEP1 2 3 | | P67eIF21 | | P671 | | EC 3.4.11.183 8 | | MAP21 2 | | EIF-2-Associated P67 Homolog2 | | Initiation Factor 2-Associated 67 KDa Glycoprotein2 3 | | Methionine Aminopeptidase 22 | | MetAP 22 3 | | P67EIF23 | | Peptidase M 22 3 | | |
Export aliases for METAP2 gene to outside databasesPrevious GC identifers: GC12M095311 GC12P096231 GC12P094370 GC12P092936 |
Summaries
for METAP2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for METAP2:
This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganeseions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitoryphosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression ofthis gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit theprotein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2. (provided byRefSeq, Jul 2008)
UniProtKB/Swiss-Prot: AMPM2_HUMAN, P50579Function: Removes the N-terminal methionine from nascent proteins. The catalytic activity of human METAP2 towardMet-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsiblefor processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivoFunction: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitorykinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis
Gene Wiki entry for METAP2
|
Genomic Views
for METAP2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the METAP2 gene promoter:
AML1a AP-1 ATF-2 HSF1 (long) Max NRF-2 HSF1short c-Jun c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for METAP2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METAP2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q22 Ensembl cytogenetic band: 12q22 HGNC cytogenetic band: 12q22METAP2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P095800: view genomic region
(about GC identifiers)
Start:
|
95,867,296 bp from pter |
End:
|
95,909,615 bp from pter |
Size:
|
42,320 bases |
Orientation:
|
plus strand |
|
Proteins
for METAP2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AMPM2_HUMAN, P50579 (See
protein sequence)Recommended Name: Methionine aminopeptidase 2 Size: 478 amino acids; 52892 Da
Cofactor: Binds 2 cobalt ions per subunit. The true nature of the physiological cofactor is under debate. The enzyme isalso active with zinc, manganese or divalent iron ions
Subunit: Interacts strongly with the eIF-2 gamma-subunit EIF2S3 (By similarity). Binds EIF2S1 at low magnesiumconcentrations
Subcellular location: Cytoplasm. Note=About 30% of expressed METAP2 associates with polysomes
6/18 PDB 3D structures from  and Proteopedia  for METAP2 (see all 18):1B59 (3D)
1B6A (3D)
1BN5 (3D)
1BOA (3D)
1KQ0 (3D)
1KQ9 (3D)
Secondary accessions: B2RDI8Explore the universe of human proteins at neXtProt for METAP2: NX_P50579
Post-translational modifications:
Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2A binding1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P50579
4/13 DME Specific Peptides for METAP2 (P50579) (see all 13)
METAP2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006829.1
ENSEMBL proteins: ENSP00000446052 ENSP00000325312 ENSP00000448169 ENSP00000261220 ENSP00000448370 ENSP00000449004 ENSP00000448614 ENSP00000450063 ENSP00000447661
Human Recombinant Protein Products for METAP2:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
METAP2 for ontologies About GeneDecksing
METAP2 Antibody Products:
Assay Products for METAP2: |
Protein
Domains /
Families
for METAP2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
METAP2 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P50579ProtoNet protein and cluster: P50579 1 Blocks protein family: IPB001714 Methionine aminopeptidase-1 signature
UniProtKB/Swiss-Prot: AMPM2_HUMAN, P50579Similarity: Belongs to the peptidase M24A family |
Function
for METAP2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: AMPM2_HUMAN, P50579Function: Removes the N-terminal methionine from nascent proteins. The catalytic activity of human METAP2 towardMet-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsiblefor processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivoFunction: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitorykinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesisCatalytic activity: Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides Enzyme Number (IUBMB): EC 3.4.11.181 2
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
METAP2 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for METAP2:
5 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Metap2):
METAP2 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Metap2tm1.2Ccr for METAP2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METAP2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METAP2 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: METAP2 (NM_006838) | |  | Sino Biological Human cDNA Clone for METAP2 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for METAP2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METAP2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METAP2 |
|
Pathways & Interactions
for METAP2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Translational Control | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for METAP2
METAP2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for METAP2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 18)
5/59 Interacting proteins for METAP2 (P505792, 3 ENSP000003253124) via UniProtKB, MINT, STRING, and/or I2D (see all 59)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
METAP2 for ontologies About GeneDecksing
|
Drugs & Compounds
for METAP2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
METAP2 for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for METAP2 |
 Compounds for METAP2 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| Fumagillin | Methionine aminopeptidase-2 inhibitor; antiangiogenic | [23110-15-8] | | TNP 470 | Methionine aminopeptidase-2 inhibitor; antiangiogenic | [129298-91-5] |
1 HMDB Compound for METAP2 About this table
10/16 DrugBank Compounds for METAP2 (see all 16) About this table
| Compound | Synonyms |
CAS
# | Type | Actions | PubMed Ids |
|---|
| L-Methionine | (S)-2-amino-4-(methylthio)butanoic acid (see all 6) | 63-68-3 | target | product of | 17114291 16540317 16917013 16823043 16789740 | | (2s,3r)-3-Amino-2-Hydroxy-5-(Ethylsulfanyl)Pentanoyl-((S)-(-)-(1-Naphthyl)Ethyl)Amide | -- | -- | target | -- | 17139284 17016423 10592235 | | N'-(2s,3r)-3-Amino-4-Cyclohexyl-2-Hydroxy-Butano-N-(4-Methylphenyl)Hydrazide | -- | -- | target | -- | 17139284 17016423 10592235 | | Ovalicin | -- | -- | target | -- | 17139284 17016423 10592235 | | (E)-(2r,3r,4s,5r)-3,4,5-Trihydroxy-2-Methoxy-8,8-Dimethyl-Non-6-Enoic Acid ((3s,6r)-6-Hydroxy-2-Oxo-Azepan-3-Yl)-Amide | -- | -- | target | -- | 17139284 17016423 | | 2-Methyl-2-Propanol | -- | -- | target | -- | 17139284 17016423 | | 3,5,6,8-Tetramethyl-N-Methyl Phenanthrolinium | -- | -- | target | -- | 17139284 17016423 | | D-Methionine | -- | 348-67-4 | target | -- | 17139284 17016423 | | (CHLOROACETYL)CARBAMIC ACID (3R,4S,5S,5R)-5-METHOXY-4-[(2R,3R)-2-METHYL-3-(3-METHYL-2-BUTENYL)OXIRANYL]-1-OXASPIRO[2.5]OCT-6-YL ESTER | -- | -- | target | -- | 10592235 | | 2-[(PHENYLSULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID | -- | -- | target | -- | 10592235 |
10/11 Novoseek chemical compound relationships for METAP2 gene (see all 11) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| fumagillin |
97.2 |
64 |
9860943 (7), 10760954 (6), 9177176 (4), 19246010 (3) (see all 24) |
| ovalicin |
97.2 |
17 |
9860943 (3), 14676204 (3), 9224570 (2), 16386852 (1) (see all 6) |
| methionine |
82.1 |
70 |
9177176 (3), 10574784 (3), 15102683 (2), 15760654 (2) (see all 36) |
| triazole |
45.4 |
3 |
15516829 (2) |
| benzimidazole |
42.4 |
1 |
15954858 (1) |
| cobalt |
41.2 |
10 |
15516829 (3), 17636946 (1), 12718546 (1) |
| epoxide |
30 |
5 |
9860943 (2), 9812898 (1) |
| vegf |
19.4 |
2 |
15927358 (1) |
| manganese |
12.6 |
7 |
12718546 (3), 15516829 (1) |
| leucine |
5.02 |
2 |
14741843 (1), 15187415 (1) |
Search CenterWatch for drugs/clinical trials and news about METAP2 / AMPM2
|
Transcripts
for METAP2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for METAP2 gene: NM_006838.3 Unigene Cluster for METAP2: Methionyl aminopeptidase 2 Hs.444986 [show with all ESTs]Unigene Representative Sequence: NM_00683811 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000535095 ENST00000323666(uc001tec.3 uc010suv.2 uc001tef.3 uc001tee.3)
ENST00000546753 ENST00000261220 ENST00000549502 ENST00000553151 ENST00000550777
ENST00000551840 ENST00000549136 ENST00000549808 ENST00000546478
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METAP2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METAP2 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: METAP2 (NM_006838) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for METAP2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METAP2 |
Additional cDNA sequence: AK055692.1 AK091730.1 AK300836.1 AK315559.1 BC013782.1 BC016008.1 U13261.1 18 DOTS entries: DT.218617 DT.218616 DT.95322384 DT.101983018 DT.100806161 DT.91771436 DT.100737178 DT.101962101 DT.100762758 DT.100828121 DT.100828123 DT.100828129 DT.121187177 DT.121187183 DT.121187197 DT.121187202 DT.95322390 DT.121187200 24/407 AceView cDNA sequences (see all 407): F02454 CB131136 CB109203 CA427033 AW298282 BG289299 BF591930 N22561 CB159534 BM800321 AA283030 AW515529 BP359367 AI473530 BE042636 BP363353 BP355502 CR620412 BM970063 CB108884 BU631055 BQ773357 BM722748 BE871881
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for METAP2 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|
|
| SP1: | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for METAP2
|
Expression
for METAP2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| METAP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See METAP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for METAP2
SOURCE GeneReport for Unigene cluster: Hs.444986
SABiosciences Expression via Pathway-Focused PCR Arrays including METAP2: | Tumor Metastasis in human mouse rat | | Molecular Toxicology PathwayFinder 384HT in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for METAP2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat METAP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METAP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METAP2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METAP2 |
Orthologs
for METAP2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for METAP2 gene from 10/41 species (see all 41) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Metap21 , 5 |
methionine aminopeptidase 21, 5 |
89.19(n)1
94.98(a)1 |
|
10 (48.69 cM)5
563071 NM_019648.31 NP_062622.11
938584895 |
chicken
(Gallus gallus) |
Aves |
METAP21 |
methionyl aminopeptidase 2 |
80.77(n)
87.58(a) |
|
417912 NM_001006233.1 NP_001006233.1 |
lizard
(Anolis carolinensis) |
Reptilia |
METAP26 |
-- |
91(a) |
1 ↔ 1 |
5(30789289-30805581) |
African clawed frog
(Xenopus laevis) |
Amphibia |
metap2-prov2 |
methionine aminopeptidase 2 |
81.44(n) |
|
BC043889.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufb98h062 |
wufb98h06 |
75.67(n) |
|
323452 BC055563.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
und1 , 3 |
methionyl aminopeptidase3
uninitiated1 |
74(a)3
61.16(n)1
68.63(a)1 |
|
30C73
342941 NM_058025.41 NP_477373.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
Y116A8A.93 |
-- |
73(a)
(best of 3) |
|
IV(16848642-16855041) -- |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
MAP2(YBL091C)4
MAP21 |
Methionine aminopeptidase, catalyzes the cotranslational more4
Map2p1 |
59.78(n)1
56.72(a)1 |
|
2(48628-47363)4
8521871, 4 NP_009462.21 NP_009462.14 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
MAP2B1 |
methionine aminopeptidase 2B |
62.93(n)
68.26(a) |
|
825169 NM_001203210.1 NP_001190139.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.123222 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
72.81(n) |
|
AK122063.1 |
ENSEMBL Gene Tree for METAP2 (if available)
TreeFam Gene Tree for METAP2 (if available) |
Paralogs
for METAP2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for METAP2 gene
- ENSG000002574112 PA2G42
1 SIMAP similar gene for METAP2 using alignment to 10 protein entries: AMPM2_HUMAN (see all proteins):PA2G4
METAP2 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for METAP2
PGOHUM00000240377 PGOHUM00000233201
|
Genomic Variants
for METAP2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for METAP2 (95867296 - 95909615 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for METAP2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing METAP2 |
|
Disorders
/ Diseases
for METAP2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
METAP2 for disorders About GeneDecksing
OMIM gene information: 601870
OMIM disorders: --
19  diseases for METAP2: About MalaCardsmicrosporidiosis non-hodgkin lymphoma hodgkin's lymphoma pulmonary fibrosis
rheumatoid arthritis colon cancer neurofibromatosis colorectal cancer
leishmaniasis fibrosis esophageal cancer esophagitis
arthritis cholangiocarcinoma osteosarcoma lung cancer
neuroblastoma adenocarcinoma malaria
1 disease from the University of Copenhagen DISEASES database for METAP2:Microsporidiosis 5 Novoseek disease relationships for METAP2 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| microsporidiosis |
75.8 |
2 |
16917013 (1), 16004378 (1) |
| cancer |
23.5 |
14 |
18264137 (4), 16386852 (2), 16789740 (1), 15523682 (1) (see all 7) |
| colon cancer |
22.7 |
4 |
16386852 (1), 19563408 (1), 15336565 (1), 19703310 (1) |
| tumors |
11.3 |
23 |
18264137 (4), 17450475 (3), 15102683 (2), 16267007 (2) (see all 7) |
| colorectal cancer |
3.45 |
1 |
16386852 (1) |
Human Genome Epidemiology (HuGE) Navigator: METAP2 (1 document)
Export disorders for METAP2 gene to outside databases
|
Publications
for METAP2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for METAP2 gene, integrated from 9 sources (see all 112):
(articles sorted by number of sources associating them with METAP2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Eukaryotic methionyl aminopeptidases: two classes of cobalt-dependent enzymes. (PubMed id 7644482)1, 2, 3, 9 Arfin S.M.... Bradshaw R.A. (1995)
- Structure of human methionine aminopeptidase-2 complexed with fumagillin. (PubMed id 9812898)1, 2, 9 Liu S.... Clardy J. (1998)
- Evidence that the human homologue of a rat initiation factor-2 associated protein (p67) is a methionine aminopeptidase. (PubMed id 8858118)1, 3, 9 Li X. and Chang Y.H. (1996)
- Molecular cloning of a human complementary DNA encoding an initiation factor 2-associated protein (p67). (PubMed id 7873610)1, 2, 9 Li X. and Chang Y. (1995)
- Protein N-terminal processing: substrate specificity of Escherichia coli and human methionine aminopeptidases. (PubMed id 20521764)1, 2 Xiao Q.... Pei D. (2010)
- Human methionine aminopeptidase type 2 in complex with L- and D- methionine. (PubMed id 16540317)2, 7 Nonato M.C.... Clardy J. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Ectopic expression of methionine aminopeptidase-2 causes cell transformation and stimulates proliferation. (PubMed id 18264137)1, 9 Tucker L.A....Wang J. (2008)
- Physiologically relevant metal cofactor for methionine aminopeptidase-2 is manganese. (PubMed id 12718546)1, 9 Wang J....Henkin J. (2003)
|
External Searches for METAP2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing METAP2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing METAP2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing METAP2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for METAP2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for METAP2 gene:
Search GeneIP for patents involving METAP2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for METAP2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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 | |
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| | |  | OriGene Antibodies for METAP2 | | OriGene shRNA RFP for METAP2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for METAP2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for METAP2 | | | OriGene Protein Over-expression Lysate for METAP2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for METAP2 | | OriGene 3'-UTR Clone for METAP2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for METAP2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for METAP2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat METAP2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing METAP2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METAP2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat METAP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METAP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat METAP2 |
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| | Antibodies & Assays for METAP2 |
| | | |  |  |  |  | | | | |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METAP2 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat METAP2 |
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