Aliases for METAP1D Gene
External Ids for METAP1D Gene
Previous GeneCards Identifiers for METAP1D Gene
The N-terminal methionine excision pathway is an essential process in which the N-terminal methionine is removed from many proteins, thus facilitating subsequent protein modification. In mitochondria, enzymes that catalyze this reaction are celled methionine aminopeptidases (MetAps, or MAPs; EC 220.127.116.11) (Serero et al., 2003 [PubMed 14532271]).[supplied by OMIM, Mar 2008]
GeneCards Summary for METAP1D Gene
METAP1D (Methionyl Aminopeptidase Type 1D, Mitochondrial) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include aminopeptidase activity and metalloaminopeptidase activity. An important paralog of this gene is METAP1.
UniProtKB/Swiss-Prot for METAP1D Gene
Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed (By similarity). May play a role in colon tumorigenesis.