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Aliases for METAP1D Gene

Aliases for METAP1D Gene

  • Methionyl Aminopeptidase Type 1D (Mitochondrial) 2 3
  • MAP1D 3 4 6
  • Methionyl Aminopeptidase Type 1D, Mitochondrial 3 4
  • Peptidase M 1D 3 4
  • MetAP 1D 3 4
  • MAP 1D 3 4
  • Methionine Aminopeptidase 1D, Mitochondrial 3
  • CDS Of MetAP-3 Within PCR Fragment 3
  • Methionine Aminopeptidase 1D 2
  • EC 3.4.11.18 4
  • Metap1l 3

External Ids for METAP1D Gene

Previous GeneCards Identifiers for METAP1D Gene

  • GC02P164748
  • GC02P172865

Summaries for METAP1D Gene

Entrez Gene Summary for METAP1D Gene

  • The N-terminal methionine excision pathway is an essential process in which the N-terminal methionine is removed from many proteins, thus facilitating subsequent protein modification. In mitochondria, enzymes that catalyze this reaction are celled methionine aminopeptidases (MetAps, or MAPs; EC 3.4.11.18) (Serero et al., 2003 [PubMed 14532271]).[supplied by OMIM, Mar 2008]

GeneCards Summary for METAP1D Gene

METAP1D (Methionyl Aminopeptidase Type 1D (Mitochondrial)) is a Protein Coding gene. GO annotations related to this gene include aminopeptidase activity and metalloexopeptidase activity. An important paralog of this gene is METAP1.

UniProtKB/Swiss-Prot for METAP1D Gene

  • Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed (By similarity). May play a role in colon tumorigenesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METAP1D Gene

Genomics for METAP1D Gene

Genomic Location for METAP1D Gene

Start:
171,999,583 bp from pter
End:
172,082,430 bp from pter
Size:
82,848 bases
Orientation:
Plus strand

Genomic View for METAP1D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for METAP1D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METAP1D Gene

No data available for Regulatory Elements for METAP1D Gene

Proteins for METAP1D Gene

  • Protein details for METAP1D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UB28-MAP12_HUMAN
    Recommended name:
    Methionine aminopeptidase 1D, mitochondrial
    Protein Accession:
    Q6UB28
    Secondary Accessions:
    • Q1WNX3

    Protein attributes for METAP1D Gene

    Size:
    335 amino acids
    Molecular mass:
    37088 Da
    Cofactor:
    Name=Co(2+); Xref=ChEBI:CHEBI:48828; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Note=Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAY55948.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for METAP1D Gene

Proteomics data for METAP1D Gene at MOPED

Post-translational modifications for METAP1D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for METAP1D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for METAP1D Gene

Domains for METAP1D Gene

Gene Families for METAP1D Gene

Suggested Antigen Peptide Sequences for METAP1D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UB28

UniProtKB/Swiss-Prot:

MAP12_HUMAN :
  • Q6UB28
Family:
  • Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
genes like me logo Genes that share domains with METAP1D: view

Function for METAP1D Gene

Molecular function for METAP1D Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=573 uM for Met-pro-p-nitroanilide (at pH 8) {ECO:0000269 PubMed:17929833}; pH dependence: Optimum pH is 7.5-8.0. {ECO:0000269 PubMed:17929833};
UniProtKB/Swiss-Prot CatalyticActivity: Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
UniProtKB/Swiss-Prot Function: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed (By similarity). May play a role in colon tumorigenesis.

Enzyme Numbers (IUBMB) for METAP1D Gene

Gene Ontology (GO) - Molecular Function for METAP1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004177 aminopeptidase activity TAS 14532271
GO:0008235 metalloexopeptidase activity TAS 14532271
GO:0046872 metal ion binding IEA --
GO:0070006 metalloaminopeptidase activity IEA --
genes like me logo Genes that share ontologies with METAP1D: view

Phenotypes for METAP1D Gene

GenomeRNAi human phenotypes for METAP1D:
genes like me logo Genes that share phenotypes with METAP1D: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for METAP1D Gene

Localization for METAP1D Gene

Subcellular locations from UniProtKB/Swiss-Prot for METAP1D Gene

Mitochondrion.

Gene Ontology (GO) - Cellular Components for METAP1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 14532271
genes like me logo Genes that share ontologies with METAP1D: view

No data available for Subcellular locations from COMPARTMENTS for METAP1D Gene

Pathways for METAP1D Gene

SuperPathways for METAP1D Gene

No Data Available

Interacting Proteins for METAP1D Gene

Gene Ontology (GO) - Biological Process for METAP1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0018206 peptidyl-methionine modification TAS 14532271
GO:0031365 N-terminal protein amino acid modification TAS 14532271
GO:0070084 protein initiator methionine removal IEA --
genes like me logo Genes that share ontologies with METAP1D: view

No data available for Pathways by source for METAP1D Gene

Transcripts for METAP1D Gene

Unigene Clusters for METAP1D Gene

Methionyl aminopeptidase type 1D (mitochondrial):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for METAP1D Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1: - -
SP2: - - -
SP3:
SP4:

Relevant External Links for METAP1D Gene

GeneLoc Exon Structure for
METAP1D
ECgene alternative splicing isoforms for
METAP1D

Expression for METAP1D Gene

mRNA expression in normal human tissues for METAP1D Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for METAP1D Gene

SOURCE GeneReport for Unigene cluster for METAP1D Gene Hs.298250

mRNA Expression by UniProt/SwissProt for METAP1D Gene

Q6UB28-MAP12_HUMAN
Tissue specificity: Overexpressed in colon cancer cell lines and colon tumors as compared to normal tissues (at protein level).
genes like me logo Genes that share expressions with METAP1D: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for METAP1D Gene

Orthologs for METAP1D Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METAP1D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METAP1D 35
  • 99.5 (n)
  • 99.7 (a)
METAP1D 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAP1D 36
  • 93 (a)
OneToOne
METAP1D 35
  • 93.39 (n)
  • 95.85 (a)
dog
(Canis familiaris)
Mammalia METAP1D 35
  • 94.43 (n)
  • 94.93 (a)
METAP1D 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Metap1d 35
  • 90.45 (n)
  • 91.04 (a)
Metap1d 16
Metap1d 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia METAP1D 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia METAP1D 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Metap1d 35
  • 87.82 (n)
  • 88.02 (a)
chicken
(Gallus gallus)
Aves METAP1D 35
  • 81.24 (n)
  • 80.54 (a)
METAP1D 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia METAP1D 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia metap1d 35
  • 80.37 (n)
  • 80.37 (a)
zebrafish
(Danio rerio)
Actinopterygii metap1d 35
  • 64.87 (n)
  • 66.47 (a)
metap1d 36
  • 65 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009013 35
  • 55.15 (n)
  • 55.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5188 35
  • 54.92 (n)
  • 51.6 (a)
CG5188 36
  • 47 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAP1 36
  • 31 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.5080 35
soybean
(Glycine max)
eudicotyledons Gma.6970 35
thale cress
(Arabidopsis thaliana)
eudicotyledons MAP1D 35
  • 54.95 (n)
  • 52.9 (a)
corn
(Zea mays)
Liliopsida Zm.3493 35
rice
(Oryza sativa)
Liliopsida Os.10727 35
Os02g0761700 35
  • 55.19 (n)
  • 51.81 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToOne
Species with no ortholog for METAP1D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for METAP1D Gene

ENSEMBL:
Gene Tree for METAP1D (if available)
TreeFam:
Gene Tree for METAP1D (if available)

Paralogs for METAP1D Gene

Paralogs for METAP1D Gene

Selected SIMAP similar genes for METAP1D Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with METAP1D: view

Variants for METAP1D Gene

Sequence variations from dbSNP and Humsavar for METAP1D Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs705869 -- 172,080,801(+) TTACA(A/C/G/T)TGATC utr-variant-3-prime
rs705870 -- 172,067,555(-) ACTCT(A/G)TTTTA intron-variant
rs718936 -- 171,998,836(-) GTTAA(C/T)CACCG upstream-variant-2KB
rs788158 -- 172,078,169(+) GGGAT(A/G)TTTGT intron-variant
rs788159 -- 172,079,922(+) ATGGC(G/T)CAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for METAP1D Gene

Variant ID Type Subtype PubMed ID
dgv4362n71 CNV Loss 21882294
nsv3031 CNV Loss 18451855
esv2721131 CNV Deletion 23290073
nsv875412 CNV Loss 21882294
dgv746e199 CNV Deletion 23128226
nsv820002 CNV Gain 19587683
dgv747e199 CNV Deletion 23128226
dgv675n67 CNV Loss 20364138
nsv820939 CNV Deletion 20802225
esv1004708 CNV Deletion 20482838
esv2721132 CNV Deletion 23290073
dgv90e180 CNV Loss 20482838
esv21895 CNV Gain+Loss 19812545
esv2721133 CNV Deletion 23290073
esv2721134 CNV Deletion 23290073
esv2721135 CNV Deletion 23290073
esv2662767 CNV Deletion 23128226
esv2721136 CNV Deletion 23290073
esv2458501 CNV Deletion 19546169

Relevant External Links for METAP1D Gene

HapMap Linkage Disequilibrium report
METAP1D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METAP1D Gene

Disorders for METAP1D Gene

Relevant External Links for METAP1D

Genetic Association Database (GAD)
METAP1D
genes like me logo Genes that share disorders with METAP1D: view

No data available for UniProtKB/Swiss-Prot for METAP1D Gene

Publications for METAP1D Gene

  1. An unusual peptide deformylase features in the human mitochondrial N- terminal methionine excision pathway. (PMID: 14532271) Serero A. … Meinnel T. (J. Biol. Chem. 2003) 2 3 4 23
  2. MAP1D, a novel methionine aminopeptidase family member is overexpressed in colon cancer. (PMID: 16568094) Leszczyniecka M. … Phillips P.E. (Oncogene 2006) 2 3 4
  3. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3

Products for METAP1D Gene

Sources for METAP1D Gene

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