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Aliases for METAP1D Gene

Aliases for METAP1D Gene

  • Methionyl Aminopeptidase Type 1D (Mitochondrial) 2 3 5
  • Methionyl Aminopeptidase Type 1D, Mitochondrial 3 4
  • Peptidase M 1D 3 4
  • MetAP 1D 3 4
  • MAP 1D 3 4
  • MAP1D 3 4
  • CDS Of MetAP-3 Within PCR Fragment 3
  • Methionine Aminopeptidase 1D 2
  • EC 4
  • Metap1l 3

External Ids for METAP1D Gene

Previous GeneCards Identifiers for METAP1D Gene

  • GC02P164748
  • GC02P172865

Summaries for METAP1D Gene

Entrez Gene Summary for METAP1D Gene

  • The N-terminal methionine excision pathway is an essential process in which the N-terminal methionine is removed from many proteins, thus facilitating subsequent protein modification. In mitochondria, enzymes that catalyze this reaction are celled methionine aminopeptidases (MetAps, or MAPs; EC (Serero et al., 2003 [PubMed 14532271]).[supplied by OMIM, Mar 2008]

GeneCards Summary for METAP1D Gene

METAP1D (Methionyl Aminopeptidase Type 1D (Mitochondrial)) is a Protein Coding gene. GO annotations related to this gene include aminopeptidase activity and metalloaminopeptidase activity. An important paralog of this gene is METAP1.

UniProtKB/Swiss-Prot for METAP1D Gene

  • Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed (By similarity). May play a role in colon tumorigenesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METAP1D Gene

Genomics for METAP1D Gene

Regulatory Elements for METAP1D Gene

Enhancers for METAP1D Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around METAP1D on UCSC Golden Path with GeneCards custom track

Promoters for METAP1D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around METAP1D on UCSC Golden Path with GeneCards custom track

Genomic Location for METAP1D Gene

171,999,583 bp from pter
172,082,430 bp from pter
82,848 bases
Plus strand

Genomic View for METAP1D Gene

Genes around METAP1D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METAP1D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METAP1D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METAP1D Gene

Proteins for METAP1D Gene

  • Protein details for METAP1D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Methionine aminopeptidase 1D, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q1WNX3

    Protein attributes for METAP1D Gene

    335 amino acids
    Molecular mass:
    37088 Da
    Name=Co(2+); Xref=ChEBI:CHEBI:48828; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    No Data Available
    • Sequence=AAY55948.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for METAP1D Gene

Proteomics data for METAP1D Gene at MOPED

Post-translational modifications for METAP1D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for METAP1D Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for METAP1D (Methionine Aminopeptidase 1D/MAP1D)
  • Abcam antibodies for MAP1D

No data available for DME Specific Peptides for METAP1D Gene

Domains & Families for METAP1D Gene

Gene Families for METAP1D Gene

Suggested Antigen Peptide Sequences for METAP1D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
  • Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
genes like me logo Genes that share domains with METAP1D: view

Function for METAP1D Gene

Molecular function for METAP1D Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=573 uM for Met-pro-p-nitroanilide (at pH 8) {ECO:0000269 PubMed:17929833}; pH dependence: Optimum pH is 7.5-8.0. {ECO:0000269 PubMed:17929833};
UniProtKB/Swiss-Prot CatalyticActivity:
Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
UniProtKB/Swiss-Prot Function:
Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed (By similarity). May play a role in colon tumorigenesis.

Enzyme Numbers (IUBMB) for METAP1D Gene

genes like me logo Genes that share phenotypes with METAP1D: view

Animal Model Products

  • Taconic Biosciences Mouse Models for METAP1D

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for METAP1D Gene

Localization for METAP1D Gene

Subcellular locations from UniProtKB/Swiss-Prot for METAP1D Gene


Subcellular locations from

Jensen Localization Image for METAP1D Gene COMPARTMENTS Subcellular localization image for METAP1D gene
Compartment Confidence
mitochondrion 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for METAP1D Gene

Pathways & Interactions for METAP1D Gene

SuperPathways for METAP1D Gene

No Data Available

Interacting Proteins for METAP1D Gene

Gene Ontology (GO) - Biological Process for METAP1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018206 peptidyl-methionine modification TAS 14532271
genes like me logo Genes that share ontologies with METAP1D: view

No data available for Pathways by source and SIGNOR curated interactions for METAP1D Gene

Drugs & Compounds for METAP1D Gene

(1) Drugs for METAP1D Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cobalt Pharma 159
genes like me logo Genes that share compounds with METAP1D: view

Transcripts for METAP1D Gene

Unigene Clusters for METAP1D Gene

Methionyl aminopeptidase type 1D (mitochondrial):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for METAP1D Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1: - -
SP2: - - -

Relevant External Links for METAP1D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for METAP1D Gene

mRNA expression in normal human tissues for METAP1D Gene

Protein differential expression in normal tissues from HIPED for METAP1D Gene

This gene is overexpressed in Bone (65.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for METAP1D Gene

SOURCE GeneReport for Unigene cluster for METAP1D Gene Hs.298250

mRNA Expression by UniProt/SwissProt for METAP1D Gene

Tissue specificity: Overexpressed in colon cancer cell lines and colon tumors as compared to normal tissues (at protein level).
genes like me logo Genes that share expression patterns with METAP1D: view

Protein tissue co-expression partners for METAP1D Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for METAP1D Gene

Orthologs for METAP1D Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METAP1D Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia METAP1D 35
  • 93.39 (n)
  • 95.85 (a)
MAP1D 36
  • 93 (a)
(Canis familiaris)
Mammalia METAP1D 35
  • 94.43 (n)
  • 94.93 (a)
  • 71 (a)
(Mus musculus)
Mammalia Metap1d 35
  • 90.45 (n)
  • 91.04 (a)
Metap1d 16
Metap1d 36
  • 91 (a)
(Pan troglodytes)
Mammalia METAP1D 35
  • 99.5 (n)
  • 99.7 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Metap1d 35
  • 87.82 (n)
  • 88.02 (a)
(Monodelphis domestica)
Mammalia METAP1D 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia METAP1D 36
  • 88 (a)
(Gallus gallus)
Aves METAP1D 35
  • 81.24 (n)
  • 80.54 (a)
  • 79 (a)
(Anolis carolinensis)
Reptilia METAP1D 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia metap1d 35
  • 80.37 (n)
  • 80.37 (a)
(Danio rerio)
Actinopterygii metap1d 35
  • 64.87 (n)
  • 66.47 (a)
metap1d 36
  • 65 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009013 35
  • 55.15 (n)
  • 55.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5188 35
  • 54.92 (n)
  • 51.6 (a)
CG5188 36
  • 47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAP1 36
  • 31 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons MAP1D 35
  • 54.95 (n)
  • 52.9 (a)
(Glycine max)
eudicotyledons Gma.6970 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.5080 35
(Oryza sativa)
Liliopsida Os.10727 35
Os02g0761700 35
  • 55.19 (n)
  • 51.81 (a)
(Zea mays)
Liliopsida Zm.3493 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
Species with no ortholog for METAP1D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for METAP1D Gene

Gene Tree for METAP1D (if available)
Gene Tree for METAP1D (if available)

Paralogs for METAP1D Gene

Paralogs for METAP1D Gene

(2) SIMAP similar genes for METAP1D Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with METAP1D: view

Variants for METAP1D Gene

Sequence variations from dbSNP and Humsavar for METAP1D Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10497377 - 172,061,498(+) CACAG(A/G/T)TTCTC reference, missense, utr-variant-5-prime
rs705869 -- 172,080,801(+) TTACA(A/C/G/T)TGATC utr-variant-3-prime
rs705870 -- 172,067,555(-) ACTCT(A/G)TTTTA intron-variant
rs718936 -- 171,998,836(-) GTTAA(C/T)CACCG upstream-variant-2KB
rs788158 -- 172,078,169(+) GGGAT(A/G)TTTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for METAP1D Gene

Variant ID Type Subtype PubMed ID
dgv4362n71 CNV Loss 21882294
nsv3031 CNV Loss 18451855
esv2721131 CNV Deletion 23290073
nsv875412 CNV Loss 21882294
dgv746e199 CNV Deletion 23128226
nsv820002 CNV Gain 19587683
dgv747e199 CNV Deletion 23128226
dgv675n67 CNV Loss 20364138
nsv820939 CNV Deletion 20802225
esv1004708 CNV Deletion 20482838
esv2721132 CNV Deletion 23290073
dgv90e180 CNV Loss 20482838
esv21895 CNV Gain+Loss 19812545
esv2721133 CNV Deletion 23290073
esv2721134 CNV Deletion 23290073
esv2721135 CNV Deletion 23290073
esv2662767 CNV Deletion 23128226
esv2721136 CNV Deletion 23290073
esv2458501 CNV Deletion 19546169

Variation tolerance for METAP1D Gene

Residual Variation Intolerance Score: 70.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.41; 77.16% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for METAP1D Gene

Disorders for METAP1D Gene

Relevant External Links for METAP1D

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for METAP1D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for METAP1D Gene

Publications for METAP1D Gene

  1. An unusual peptide deformylase features in the human mitochondrial N- terminal methionine excision pathway. (PMID: 14532271) Serero A. … Meinnel T. (J. Biol. Chem. 2003) 2 3 4 23 67
  2. MAP1D, a novel methionine aminopeptidase family member is overexpressed in colon cancer. (PMID: 16568094) Leszczyniecka M. … Phillips P.E. (Oncogene 2006) 2 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. (PMID: 23535729) Michailidou K. … Easton D.F. (Nat. Genet. 2013) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for METAP1D Gene

Sources for METAP1D Gene