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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

METAP1 Gene

protein-coding   GIFtS: 67
GCID: GC04P099916

Methionyl Aminopeptidase 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Methionyl Aminopeptidase 11 2     MAP1A2
MetAP 12 3     MetAP1A2
Peptidase M 12 3     Methionine Aminopeptidase 12
MAP 12 3     EC 3.4.11.183
Peptidase M1     KIAA00943

External Ids:    HGNC: 157891   Entrez Gene: 231732   Ensembl: ENSG000001640247   OMIM: 6101515   UniProtKB: P535823   

Export aliases for METAP1 gene to outside databases

Previous GC identifers: GC04P100162 GC04P100309 GC04P100375 GC04P100274 GC04P095655


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for METAP1 Gene: 
METAP1 (methionyl aminopeptidase 1) is a protein-coding gene. Diseases associated with METAP1 include pneumonia, and tuberculosis, and among its related super-pathways are Visual signal transduction- Rods and Retinoid metabolism and transport. GO annotations related to this gene include metalloexopeptidase activity and aminopeptidase activity. An important paralog of this gene is METAP1D.

UniProtKB/Swiss-Prot: MAP11_HUMAN, P53582
Function: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is
often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro,
Ser, Thr, or Val). Required for normal progression through the cell cycle

Gene Wiki entry for METAP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the METAP1 gene promoter:
         TBP   FOXD3   CUTL1   Evi-1   AREB6   CREB   Nkx6-1   deltaCREB   TFIID   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMETAP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for METAP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat METAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q23   Ensembl cytogenetic band:  4q23   HGNC cytogenetic band: 4q23

METAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
METAP1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P099916:  view genomic region     (about GC identifiers)

Start:
99,916,771 bp from pter      End:
99,983,964 bp from pter
Size:
67,194 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MAP11_HUMAN, P53582 (See protein sequence)
Recommended Name: Methionine aminopeptidase 1  
Size: 386 amino acids; 43215 Da
Cofactor: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site.
The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese
or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases
under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the
histidine-containing high-affinity site (By similarity)
Cofactor: Binds 1 sodium ion per subunit. The sodium ion has a structural role
Subunit: Associates with the 60S ribosomal subunit of the 80S translational complex (By similarity)
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=AAH30054.1; Type=Erroneous initiation; Sequence=BAA07679.1; Type=Erroneous initiation;
6/13 PDB 3D structures from and Proteopedia for METAP1 (see all 13):
2B3H (3D)        2B3K (3D)        2B3L (3D)        2G6P (3D)        2GZ5 (3D)        2NQ6 (3D)    
Secondary accessions: B4E2E6

Explore the universe of human proteins at neXtProt for METAP1: NX_P53582

Explore proteomics data for METAP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P53582

  • METAP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    METAP1 Protein Expression
    REFSEQ proteins: NP_055958.2  
    ENSEMBL proteins: 
     ENSP00000296411   ENSP00000427563   ENSP00000426702   ENSP00000424462   ENSP00000427187  
     ENSP00000423071   ENSP00000422689   ENSP00000440993  
    Reactome Protein details: P53582
    Human Recombinant Protein Products for METAP1: 
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    Novus Biologicals METAP1 Proteins
    Novus Biologicals METAP1 Lysates
    Sino Biological Recombinant Protein for METAP1
    Sino Biological Cell Lysate for METAP1 
    ProSpec Recombinant Protein for METAP1
    Cloud-Clone Corp. Proteins for METAP1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS14532271
    GO:0005829cytosol TAS--

    METAP1 for ontologies           About GeneDecksing



    METAP1 Antibody Products: 
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    ThermoFisher Antibodies for METAP1
    LSBio Antibodies in human, mouse, rat for METAP1 

    Assay Products for METAP1: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for METAP1 
    Cloud-Clone Corp. CLIAs for METAP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: Methionyl aminopeptidase 1 
    Aminopeptidases

    3 InterPro protein domains:
     IPR000994 Pept_M24_structural-domain
     IPR002467 Pept_M24A_MAP1
     IPR001714 Pept_M24_MAP

    Graphical View of Domain Structure for InterPro Entry P53582

    ProtoNet protein and cluster: P53582

    3 Blocks protein domains:
    IPB001714 Methionine aminopeptidase-1 signature
    IPB002223 Pancreatic trypsin inhibitor (Kunitz)
    IPB002467 Methionine aminopeptidase


    UniProtKB/Swiss-Prot: MAP11_HUMAN, P53582
    Similarity: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily


    METAP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAP11_HUMAN, P53582
    Function: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is
    often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro,
    Ser, Thr, or Val). Required for normal progression through the cell cycle
    Catalytic activity: Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides

         Enzyme Number (IUBMB): EC 3.4.11.181

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004177aminopeptidase activity TAS16386852
    GO:0008235metalloexopeptidase activity TAS16386852
    GO:0046872metal ion binding IEA--
         
    METAP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for METAP1:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for METAP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for METAP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for METAP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for METAP1 

    miRNA
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    miRTarBase miRNAs that target METAP1:
    hsa-mir-338-3p (MIRT003040)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat METAP1
    8/73 QIAGEN miScript miRNA Assays for microRNAs that regulate METAP1 (see all 73):
    hsa-miR-548j hsa-miR-520e hsa-miR-106a hsa-miR-10b* hsa-miR-877* hsa-miR-93 hsa-miR-548a-5p hsa-miR-520b
    SwitchGear 3'UTR luciferase reporter plasmidMETAP1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METAP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for METAP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Visual signal transduction- Rods
    The phototransduction cascade0.54
    Inactivation, recovery and regulation of the phototransduction cascade0.51
    2Visual phototransduction
    Visual phototransduction0.48
    Diseases associated with visual transduction0.47
    3Signaling by GPCR
    Signal Transduction0.55
    4Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5/6        Reactome Pathways for METAP1 (see all 6)
        Diseases associated with visual transduction
    The phototransduction cascade
    Signal Transduction
    Visual phototransduction
    Disease



    METAP1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for METAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/40 Interacting proteins for METAP1 (P535822, 3 ENSP000002964114) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD9O151982, 3MINT-62097 I2D: score=2 
    CBWD1Q9BRT83, ENSP000003489154I2D: score=3 STRING: ENSP00000348915
    METAP2P505793, ENSP000003253124I2D: score=2 STRING: ENSP00000325312
    SMARCD1Q96GM53I2D: score=5 
    SPENQ96T583I2D: score=4 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006417regulation of translation TAS16386852
    GO:0006508proteolysis IEA--
    GO:0007603phototransduction, visible light TAS--
    GO:0009987cellular process ----
    GO:0016056rhodopsin mediated signaling pathway TAS--

    METAP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    METAP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for METAP1 (MAP11)

    2 HMDB Compounds for METAP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CobaltCo (see all 6)7440-48-4--
    SodiumSodium (see all 2)7440-23-5--

    5 DrugBank Compounds for METAP1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    3-[(2,2-DIMETHYLPROPANOYL)AMINO]-N-1,3-THIAZOL-2-YLPYRIDINE-2-CARBOXAMIDE-- --target--10592235
    5-CHLORO-6-METHYL-N-(2-PHENYLETHYL)-2-PYRIDIN-2-YLPYRIMIDIN-4-AMINE-- --target--10592235
    Nitroxoline5-Nitroks (see all 6)4008-48-4targetinhibitor21088277
    Ovalicin-- --target--10592235
    TERT-BUTYL {2-[(1,3-THIAZOL-2-YLAMINO)CARBONYL]PYRIDIN-3-YL}CARBAMATE-- --target--10592235

    1 Novoseek inferred chemical compound relationship for METAP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fumagillin 90.3 5 10760954 (3), 14676204 (1)

    Search CenterWatch for drugs/clinical trials and news about METAP1 / MAP11

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for METAP1 gene: 
    NM_015143.2  

    Unigene Cluster for METAP1:

    Methionyl aminopeptidase 1
    Hs.480364  [show with all ESTs]
    Unigene Representative Sequence: CR936632
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296411(uc003huf.4 uc003hug.3 uc010ild.3) ENST00000510209
    ENST00000507537 ENST00000506238 ENST00000503247 ENST00000510107 ENST00000513199
    ENST00000506548 ENST00000513097 ENST00000510133 ENST00000514051 ENST00000544031

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/73 QIAGEN miScript miRNA Assays for microRNAs that regulate METAP1 (see all 73):
    hsa-miR-548j hsa-miR-520e hsa-miR-106a hsa-miR-10b* hsa-miR-877* hsa-miR-93 hsa-miR-548a-5p hsa-miR-520b
    SwitchGear 3'UTR luciferase reporter plasmidMETAP1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK304239.1 AK309465.1 BC030054.1 CR936632.1 D42084.1 

    13 DOTS entries:

    DT.115652  DT.75151368  DT.102831669  DT.121270750  DT.121270772  DT.91766662  DT.91766663  DT.91849770 
    DT.97853262  DT.100894282  DT.121270754  DT.95238690  DT.99995163 

    24/193 AceView cDNA sequences (see all 193):

    BQ232415 AW673675 AA205374 BU845971 AI932777 BM475567 AW629690 AA463816 
    AA401877 BM765522 AI702286 AI654596 CA312604 BU845884 BM478956 CA422023 
    H73080 BP356182 AU130104 BQ950875 AA383391 AI052689 CA407042 BG574066 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for METAP1 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
    SP1:        -     -                       -                                                                                       
    SP2:              -                       -                                                                                       
    SP3:                                                                                                                              
    SP4:                                                                                                                              
    SP5:                                                                                            -     -                           


    ECgene alternative splicing isoforms for METAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    METAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAATTATTT
    METAP1 Expression
    About this image


    See METAP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for METAP1

    SOURCE GeneReport for Unigene cluster: Hs.480364
        SABiosciences Custom PCR Arrays for METAP1
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat METAP1
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for METAP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for METAP1 gene from 10/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Metap11 , 5 methionyl aminopeptidase 11, 5 90.93(n)1
    98.19(a)1
      3 (64.27 cM)5
    756241  NM_175224.41  NP_780433.11 
     1384589605 
    chicken
    (Gallus gallus)
    Aves METAP11 methionyl aminopeptidase 1 84.5(n)
    95.06(a)
      422704  NM_001031151.1  NP_001026322.1 
    lizard
    (Anolis carolinensis)
    Reptilia METAP16
    Methionine aminopeptidase
    92(a)
    1 ↔ 1
    GL343307.1(1444971-1464499)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.290162 Xenopus laevis, clone IMAGE5542221, mRNA, partial cds 80.61(n)    BC046685.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc84e122 Transcribed sequence with weak similarity to protein more 81.53(n)    CB359055.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG136301 CG13630 61.73(n)
    64.15(a)
      42943  NM_143024.2  NP_651281.1 
    worm
    (Caenorhabditis elegans)
    Secernentea map-11 Protein MAP-1 59.62(n)
    64.79(a)
      177128  NM_067995.2  NP_500396.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MAP1(YLR244C)4
    MAP11
    Methionine aminopeptidase, catalyzes the cotranslational more4
    Map1p1
    59.25(n)1
    54.91(a)1
      12(626331-625168)4
    8509451, 4  NP_013345.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MAP1A1 methionine aminopeptidase 1A 60.96(n)
    59.94(a)
      819132  NM_130087.3  NP_182049.1 
    rice
    (Oryza sativa)
    Liliopsida Os.61542 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 75.95(n)    AK066207.1 


    ENSEMBL Gene Tree for METAP1 (if available)
    TreeFam Gene Tree for METAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for METAP1 gene
    METAP1D2  
    1 SIMAP similar gene for METAP1 using alignment to 7 protein entries:     MAP11_HUMAN (see all proteins):
    DKFZp781C0419

    METAP1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for METAP1
    PGOHUM00000239748


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1212 SNPs in METAP1 are shown (see all 1212)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs623232341,2
    F--99914868(+) CGCAGG/CTGCTG 1 -- us2k12Minor allele frequency- C:0.33NA CSA 3
    rs68482461,2
    C,F,A,H--99915019(+) ctgccT/Accaca 1 -- us2k111Minor allele frequency- A:0.49NS EA NA CSA WA 779
    rs605137191,2
    F--99915116(+) AAGCAC/TGGCCA 1 -- us2k13Minor allele frequency- T:0.47CSA WA 121
    rs1925278751,2
    --99915128(+) AATGGC/GAGCTG 1 -- us2k10--------
    rs1845185841,2
    --99915274(+) CAAACA/GACAAA 1 -- us2k10--------
    rs790959601,2
    C,F--99915313(+) AAATCA/GGGTAA 1 -- us2k11Minor allele frequency- G:0.07WA 118
    rs729089531,2
    C,F--99915421(+) TGTATG/ATATGC 1 -- us2k12Minor allele frequency- A:0.28WA 120
    rs1121369401,2
    C--99915491(+) CTAAGT/-TTTTT 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1485057751,2
    C--99915509(+) GAGACA/TTGGTC 1 -- us2k10--------
    rs68179911,2
    C,F--99915520(+) ttgctC/Ttgccg 1 -- us2k15Minor allele frequency- T:0.31WA NA EA 362

    HapMap Linkage Disequilibrium report for METAP1 (99916771 - 99983964 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for METAP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2728031CNV Deletion23290073
    esv2728032CNV Deletion23290073
    esv2728030CNV Deletion23290073
    nsv4438CNV Insertion18451855
    nsv879656CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610151    OMIM disorders: --

    4 diseases for METAP1:    About MalaCards
    pneumonia    tuberculosis    pancreatitis    endotheliitis


    METAP1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): METAP1
    Human Genome Epidemiology (HuGE) Navigator: METAP1 (2 documents)

    Export disorders for METAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for METAP1 gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with METAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7788527)1, 2, 3 Nagase T....Kotani H. (1995)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PubMed id 19898482)1, 4 Ross C.J....Hayden M.R. (2009)
    4. Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression. (PubMed id 17114291)1, 2 Hu X.... Liu J.O. (2006)
    5. Structural basis for the functional differences between type I and type II human methionine aminopeptidases. (PubMed id 16274222)1, 2 Addlagatta A.... Matthews B.W. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Functional expression of human methionine aminopeptidase type 1 in Saccharomyces cerevisiae. (PubMed id 12144506)1, 3 Dummitt B....Chang Y.H. (2002)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23173 HGNC: 15789 AceView: METAP1 Ensembl:ENSG00000164024 euGenes: HUgn23173
    ECgene: METAP1 H-InvDB: METAP1

    (According to HUGE)
    About This Section
    HUGE: KIAA0094

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for METAP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for METAP1 gene:
    Search GeneIP for patents involving METAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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