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Aliases for METAP1 Gene

Aliases for METAP1 Gene

  • Methionyl Aminopeptidase 1 2 3
  • Peptidase M 1 3 4
  • MetAP 1 3 4
  • MAP 1 3 4
  • Methionine Aminopeptidase 1 3
  • EC 3.4.11.18 4
  • Peptidase M 2
  • KIAA0094 4
  • MetAP1A 3
  • MAP1A 3

External Ids for METAP1 Gene

Previous GeneCards Identifiers for METAP1 Gene

  • GC04P100162
  • GC04P100309
  • GC04P100375
  • GC04P100274
  • GC04P099916
  • GC04P095655

Summaries for METAP1 Gene

GeneCards Summary for METAP1 Gene

METAP1 (Methionyl Aminopeptidase 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include aminopeptidase activity and metalloexopeptidase activity. An important paralog of this gene is METAP1D.

UniProtKB/Swiss-Prot for METAP1 Gene

  • Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle.

Gene Wiki entry for METAP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for METAP1 Gene

Genomics for METAP1 Gene

Regulatory Elements for METAP1 Gene

Genomic Location for METAP1 Gene

Start:
98,995,620 bp from pter
End:
99,062,813 bp from pter
Size:
67,194 bases
Orientation:
Plus strand

Genomic View for METAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for METAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METAP1 Gene

Proteins for METAP1 Gene

  • Protein details for METAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53582-MAP11_HUMAN
    Recommended name:
    Methionine aminopeptidase 1
    Protein Accession:
    P53582
    Secondary Accessions:
    • B4E2E6

    Protein attributes for METAP1 Gene

    Size:
    386 amino acids
    Molecular mass:
    43215 Da
    Cofactor:
    Name=Co(2+); Xref=ChEBI:CHEBI:48828; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Note=Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.;
    Cofactor:
    Name=Na(+); Xref=ChEBI:CHEBI:29101; Note=Binds 1 sodium ion per subunit. The sodium ion has a structural role.;
    Quaternary structure:
    • Associates with the 60S ribosomal subunit of the 80S translational complex.
    SequenceCaution:
    • Sequence=AAH30054.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA07679.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for METAP1 Gene

neXtProt entry for METAP1 Gene

Proteomics data for METAP1 Gene at MOPED

Post-translational modifications for METAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for METAP1 Gene

No data available for DME Specific Peptides for METAP1 Gene

Domains for METAP1 Gene

Gene Families for METAP1 Gene

Suggested Antigen Peptide Sequences for METAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P53582

UniProtKB/Swiss-Prot:

MAP11_HUMAN :
  • P53582
Family:
  • Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
genes like me logo Genes that share domains with METAP1: view

Function for METAP1 Gene

Molecular function for METAP1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
UniProtKB/Swiss-Prot Function: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle.

Enzyme Numbers (IUBMB) for METAP1 Gene

Gene Ontology (GO) - Molecular Function for METAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004177 aminopeptidase activity TAS 16386852
GO:0008235 metalloexopeptidase activity TAS 16386852
GO:0016787 hydrolase activity --
GO:0046872 metal ion binding IEA --
GO:0070006 metalloaminopeptidase activity IEA --
genes like me logo Genes that share ontologies with METAP1: view

Phenotypes for METAP1 Gene

GenomeRNAi human phenotypes for METAP1:
genes like me logo Genes that share phenotypes with METAP1: view

miRNA for METAP1 Gene

miRTarBase miRNAs that target METAP1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for METAP1 Gene

Localization for METAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for METAP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for METAP1 Gene COMPARTMENTS Subcellular localization image for METAP1 gene
Compartment Confidence
cytosol 2
chloroplast 1
cytoskeleton 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for METAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm TAS 14532271
GO:0005829 cytosol TAS --
GO:0022626 cytosolic ribosome IEA --
genes like me logo Genes that share ontologies with METAP1: view

Pathways for METAP1 Gene

genes like me logo Genes that share pathways with METAP1: view

Gene Ontology (GO) - Biological Process for METAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation TAS 16386852
GO:0006508 proteolysis IEA --
GO:0007603 phototransduction, visible light TAS --
GO:0008152 metabolic process --
GO:0016056 rhodopsin mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with METAP1: view

Compounds for METAP1 Gene

(2) HMDB Compounds for METAP1 Gene

Compound Synonyms Cas Number PubMed IDs
Cobalt
  • Co
7440-48-4
Sodium
  • Sodium
7440-23-5

(1) Novoseek inferred chemical compound relationships for METAP1 Gene

Compound -log(P) Hits PubMed IDs
fumagillin 90.3 4
genes like me logo Genes that share compounds with METAP1: view

Transcripts for METAP1 Gene

Unigene Clusters for METAP1 Gene

Methionyl aminopeptidase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for METAP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
SP1: - - -
SP2: - -
SP3:
SP4:
SP5: - -
SP6: -
SP7: -

Relevant External Links for METAP1 Gene

GeneLoc Exon Structure for
METAP1
ECgene alternative splicing isoforms for
METAP1

Expression for METAP1 Gene

mRNA expression in normal human tissues for METAP1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for METAP1 Gene

SOURCE GeneReport for Unigene cluster for METAP1 Gene Hs.480364

genes like me logo Genes that share expressions with METAP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for METAP1 Gene

Orthologs for METAP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for METAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METAP1 35
  • 99.65 (n)
  • 99.74 (a)
METAP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia METAP1 35
  • 92.92 (n)
  • 98.19 (a)
METAP1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia METAP1 35
  • 94.35 (n)
  • 98.56 (a)
METAP1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Metap1 35
  • 90.93 (n)
  • 98.19 (a)
Metap1 16
Metap1 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia METAP1 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Metap1 35
  • 89.46 (n)
  • 97.93 (a)
chicken
(Gallus gallus)
Aves METAP1 35
  • 84.5 (n)
  • 95.06 (a)
METAP1 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia METAP1 36
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.29016 35
tropical clawed frog
(Silurana tropicalis)
Amphibia metap1 35
  • 80.21 (n)
  • 89.84 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6937 35
zebrafish
(Danio rerio)
Actinopterygii metap1 35
  • 75.58 (n)
  • 86.75 (a)
metap1 36
  • 82 (a)
OneToOne
wufc84e12 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003700 35
  • 62.02 (n)
  • 66.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13630 35
  • 61.65 (n)
  • 63.98 (a)
CG13630 36
  • 63 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea map-1 35
  • 59.64 (n)
  • 64.61 (a)
map-1 36
  • 62 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL122W 35
  • 55.56 (n)
  • 54.78 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAP1 35
  • 59.15 (n)
  • 54.91 (a)
MAP1 36
  • 48 (a)
OneToMany
MAP1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D18436g 35
  • 56.71 (n)
  • 54.49 (a)
soybean
(Glycine max)
eudicotyledons Gma.10853 35
thale cress
(Arabidopsis thaliana)
eudicotyledons MAP1A 35
  • 60.87 (n)
  • 59.67 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.11208 35
corn
(Zea mays)
Liliopsida Zm.16004 35
rice
(Oryza sativa)
Liliopsida Os.6154 35
Os10g0508400 35
  • 59.02 (n)
  • 57.73 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.7894 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06923 35
  • 56.46 (n)
  • 59.77 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes fma1 35
  • 57.46 (n)
  • 55.52 (a)
Species with no ortholog for METAP1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for METAP1 Gene

ENSEMBL:
Gene Tree for METAP1 (if available)
TreeFam:
Gene Tree for METAP1 (if available)

Paralogs for METAP1 Gene

Paralogs for METAP1 Gene

Selected SIMAP similar genes for METAP1 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for METAP1 Gene

genes like me logo Genes that share paralogs with METAP1: view

Variants for METAP1 Gene

Sequence variations from dbSNP and Humsavar for METAP1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs15193 -- 99,062,680(+) TGAAT(A/C)TGGTA utr-variant-3-prime
rs1020624 -- 99,023,703(-) CACAA(C/T)ATATC intron-variant, utr-variant-5-prime
rs1037475 -- 99,031,559(-) ACCCA(C/T)GGTCA intron-variant, utr-variant-5-prime
rs1037476 -- 99,031,456(-) GGAAG(A/G)AAAAG intron-variant
rs1230159 -- 99,005,937(+) gctga(A/G)ggtga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for METAP1 Gene

Variant ID Type Subtype PubMed ID
esv2728030 CNV Deletion 23290073
esv2728031 CNV Deletion 23290073
esv2728032 CNV Deletion 23290073
nsv4438 CNV Insertion 18451855
nsv879656 CNV Gain 21882294

Relevant External Links for METAP1 Gene

HapMap Linkage Disequilibrium report
METAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for METAP1 Gene

Disorders for METAP1 Gene

Relevant External Links for METAP1

Genetic Association Database (GAD)
METAP1
Human Genome Epidemiology (HuGE) Navigator
METAP1
genes like me logo Genes that share disorders with METAP1: view

No data available for UniProtKB/Swiss-Prot for METAP1 Gene

Publications for METAP1 Gene

  1. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7788527) Nagase T. … Nomura N. (DNA Res. 1995) 2 3 4
  2. Functional expression of human methionine aminopeptidase type 1 in Saccharomyces cerevisiae. (PMID: 12144506) Dummitt B. … Chang Y.H. (Protein Pept. Lett. 2002) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Structural basis for the functional differences between type I and type II human methionine aminopeptidases. (PMID: 16274222) Addlagatta A. … Matthews B.W. (Biochemistry 2005) 3 4
  5. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PMID: 19898482) Ross C.J. … Hayden M.R. (Nat. Genet. 2009) 3 48

Products for METAP1 Gene

Sources for METAP1 Gene

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