Aliases for MET Gene
Aliases for MET Gene
External Ids for MET Gene
- HGNC: 7029
- Entrez Gene: 4233
- Ensembl: ENSG00000105976
- OMIM: 164860
- UniProtKB: P08581
Previous GeneCards Identifiers for MET Gene
- GC07P114790
- GC07P115853
- GC07P115866
- GC07P115906
- GC07P116099
- GC07P116312
- GC07P110678
Summaries for MET Gene
-
The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for MET Gene
MET (MET Proto-Oncogene, Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with MET include Renal Cell Carcinoma, Papillary and Deafness, Autosomal Recessive, 97. Among its related pathways are Glioma and Bacterial invasion of epithelial cells. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is RYK.
UniProtKB/Swiss-Prot for MET Gene
-
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells.
-
Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells.
-
The MET receptor, also known as hepatocyte growth factor receptor (HGFR), is a proto-oncogenic receptor tyrosine kinase. The endogenous ligand for MET is hepatocyte growth factor/scatter factor (HGF), a disulfide-linked heterodimeric molecule.
No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MET Gene
Genomics for MET Gene
Regulatory Elements for MET Gene
Enhancers for MET Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around MET on UCSC Golden Path with GeneCards custom track
Promoters for MET Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around MET on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for MET Gene
- Chromosome:
- 7
- Start:
- 116,672,390 bp from pter
- End:
- 116,798,386 bp from pter
- Size:
- 125,997 bases
- Orientation:
- Plus strand
Genomic View for MET Gene
Genes around MET on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q31.2 by Ensembl
- 7q31 by Entrez Gene
- 7q31 by HGNC
MET Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MET Gene
Proteins for MET Gene
-
Protein details for MET Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P08581-MET_HUMAN
- Recommended name:
- Hepatocyte growth factor receptor
- Protein Accession:
- P08581
- A1L467
- B5A932
- E7EQ94
- O60366
- Q12875
- Q9UDX7
- Q9UPL8
Protein attributes for MET Gene
- Size:
- 1390 amino acids
- Molecular mass:
- 155541 Da
- Quaternary structure:
-
- Heterodimer made of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1. Interacts when phosphorylated with downstream effectors including STAT3, PIK3R1, SRC, PCLG1, GRB2 and GAB1. Interacts with SPSB1, SPSB2 and SPSB4 (By similarity). Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation. Interacts with GRB10. Interacts with PTPN1 and PTPN2.
Three dimensional structures from OCA and Proteopedia for MET Gene
Protein Expression for MET Gene
Selected DME Specific Peptides for MET Gene
- P08581:
-
- IGRGHFGCVYHGTLLDND
- KANLSGG
- KSEMNVNM
- SPILTSGDSD
- VDTYYDDQLISCGSV
- FLWLKKRKQ
- DNINMAL
- SVRRLKET
- LHEHHIFLGATNYIYVLNEEDLQKVAE
- SGGVWKDN
- RDLAARN
- SCTLTLSEST
- APLEGGT
- GNENVLEIKGNDIDPEAVKGEVLKVGNKSCE
- LVQAVQHVVIGP
- EYKTGPV
- IDPEAVKGEVLKVGNKSCENIH
- LDSHPVS
- MNVNMKYQLPNFTA
- VLLGNESC
- KGDLTIANLGTSEGRF
- STVLGKVIVQPDQN
- AVLCTVP
- KPGAQLA
- LIGFGLQVA
- LPVKWMA
- GFMFLTDQSY
- SILECYTP
- NSSYFPDH
- KDRFINFFVGNTI
- GVFAQSKPDSAEPM
- ELVSRISAIFS
- CPDCVVSALG
- FVQCGWC
- HVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLD
- LGKVIVQPDQNFTGLI
- GECKEAL
- DEYRTEFTTA
- TVACQHRS
- PDQNFTGLIAGV
- EGSPLVVLPYMKHGDLRNFIRNE
- RGTCQRH
- HFQSCSQCL
- ELNIEWKQA
- CVAPYPSLLSS
- FIYFLTVQ
- DLLKLNS
- PVITSISP
- YREDPIV
- RPSFSELVS
- YQLPNFTAET
- IPLNGLGC
- FHTRIIRFCS
- CAFPIKY
- GGTLLTL
- SKYFDLIYVH
- QPEYCPD
- LKCTVGPA
- DDILFGVFAQSKPDSAEP
- FTVKVADFGLAR
- HGTTQYSTFSYVDP
- KQIKDLGSELVRYD
- SGTWTQQICLPAIYKVFP
- KLKIDLA
- NTLKCTVG
- KSDVWSFG
- HTPHLDRLVSARS
- EVMLKCWHP
- CGWDFGF
- FSYREDP
- DCSSKAN
- FLTDQSYIDVLP
- MKDFSHPNV
- KCVRSEEC
- NNKFDLKKT
- YVHNPVF
- CRQVQYPLTD
- FFNKIVNKNNV
- EMPLECILTEKR
- LECYTPAQ
- FRDSYPIKY
- EDPIVYEIHPTKSFISGGSTITG
- TGPVLEHP
- DLFMGQF
- DKEYYSV
- WMALESL
- GKNLNSVS
- EVFNILQAAYV
- FVHRDLA
- TCTLKSVS
- LHSISVRR
- VLLTSISTF
- FEKPVMIS
Post-translational modifications for MET Gene
- Autophosphorylated in response to ligand binding on Tyr-1234 and Tyr-1235 in the kinase domain leading to further phosphorylation of Tyr-1349 and Tyr-1356 in the C-terminal multifunctional docking site. Dephosphorylated by PTPRJ at Tyr-1349 and Tyr-1365. Dephosphorylated by PTPN1 and PTPN2.
- Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation.
- Ubiquitination at Lys 962
- Glycosylation at Asn 45, Asn 106, Asn 149, Asn 202, Asn 399, Asn 405, Asn 607, Asn 635, Asn 785, Asn 879, and Asn 930
- Modification sites at PhosphoSitePlus
Other Protein References for MET Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for MET
- R&D Systems Antibodies for MET (HGF R/c-MET)
- Cell Signaling Technology (CST) Antibodies for MET (Met)
-
Custom Antibody ServicesOriGene Antibodies for MET
- Novus Biologicals Antibodies for MET
-
Cloud-Clone Corp. Antibodies for MET
- Invitrogen Antibodies for MET
- antibodies-online Antibodies for MET: See all 660
- GeneTex MET antibody for MET
-
Santa Cruz Biotechnology (SCBT) Antibodies for MET
Protein Products
- EMD Millipore Purified and/or Recombinant MET Protein
- R&D Systems Proteins and Enzymes for MET (HGF R/c-MET)
-
OriGene Purified Proteins for MET
- Search Origene for MassSpec and Protein Over-expression Lysates for MET
- Origene Custom Protein Services for MET
- Sino Biological Cell Lysates for MET
- Sino Biological Recombinant Proteins for MET
- ProSpec Recombinant Proteins for MET
-
Cloud-Clone Corp. Proteins for MET
- antibodies-online Proteins for MET: See all 29
- Search antibodies-online for peptides
- GeneTex MET (Active) recombinant protein (GTX65521) for MET
Assay Products
- EMD Millipore Kits and Assays for MET
-
Custom Assay ServicesOriGene ELISA Kits for MET
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for MET (HGF R/c-MET)
- Cell Signaling Technology (CST) Sandwich ELISA Kits for MET (Met)
-
Cloud-Clone Corp Assay Kits for MET
- antibodies-online Kits for MET: See all 1
- Abcam assays for Met (pY1234/pY1235)
- Abcam assays for Met (pY1234/pY1235) + total Met
Domains & Families for MET Gene
Gene Families for MET Gene
Protein Domains for MET Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MET Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P08581UniProtKB/Swiss-Prot:
MET_HUMAN :- The kinase domain is involved in SPSB1 binding.
- Belongs to the protein kinase superfamily. Tyr protein kinase family.
- Domain:
-
- The kinase domain is involved in SPSB1 binding.
- The beta-propeller Sema domain mediates binding to HGF.
- Contains 3 IPT/TIG domains.
- Contains 1 protein kinase domain.
- Contains 1 Sema domain.
- Family:
-
- Belongs to the protein kinase superfamily. Tyr protein kinase family.
Function for MET Gene
Molecular function for MET Gene
- GENATLAS Biochemistry:
- met proto-oncogene,transmembrane receptor (tyrosine kinase) for hepatocyte growth factor,with two alternatively spliced isoforms,important regulator of cell proliferation and differentiation,organ regeneration,embryogenesis and tumorogenesis,amplified in the glioblastomas,mutated in childhood hepatocellular carcinomas and hereditary papillary renal carcinomas (role in the acceleration of carcinogenesis),paralog to MST1R
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity.
- UniProtKB/Swiss-Prot Function:
- Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells.
- UniProtKB/Swiss-Prot Function:
- Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells.
Enzyme Numbers (IUBMB) for MET Gene
- EC 2.7.10.1 63 4
- EC 2.7.10 63
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004713 | protein tyrosine kinase activity | TAS | -- |
| GO:0017154 | semaphorin receptor activity | IEA | -- |
Phenotypes for MET Gene
- MGI mutant phenotypes for MET:
-
inferred from 21 alleles
- cellular phenotype
- mortality/aging
- behavior/neurological phenotype
- endocrine/exocrine gland phenotype
- liver/biliary system phenotype
- normal phenotype
- immune system phenotype
- cardiovascular system phenotype
- growth/size/body region phenotype
- tumorigenesis
- homeostasis/metabolism phenotype
- digestive/alimentary phenotype
- respiratory system phenotype
- embryo phenotype
- nervous system phenotype
- vision/eye phenotype
- muscle phenotype
- limbs/digits/tail phenotype
- renal/urinary system phenotype
- craniofacial phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for MET:
-
- Increased shRNA abundance (Z-score > 2)
- Transferrin accumulation in the perinuclear area
- Decreased substrate adherent cell growth
- Decreased shRNA abundance (Z-score < -2)
- Decreased cell migration
- Weakly decreased NFAT1-GFP nuclear translocation
- Increased cell viability after pRB stimulation
- Increased mitotic index
- Decreased telomerase activity
- Increased simian virus 40 (SV40) infection
- Decreased viability after Chlamydia trachomatis serovar L2 infection and TNF-alpha/CHX stimulation
- Decreased viability in Von Hippel-Lindau (VHL) (-/-) cell line
Animal Models for MET Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for MET gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MET gene
- Search ViGene Biosciences for MET
CRISPR Products
-
OriGene CRISPR knockouts for MET
-
Santa Cruz Biotechnology (SCBT) CRISPR for MET
- GenScript: Design CRISPR guide RNA sequences for MET
miRNA for MET Gene
- miRTarBase miRNAs that target MET
-
- hsa-mir-206 (MIRT000185)
- hsa-mir-34c-5p (MIRT000757)
- hsa-mir-34b-5p (MIRT000758)
- hsa-mir-34a-5p (MIRT000759)
- hsa-mir-1-3p (MIRT001357)
- hsa-mir-199a-3p (MIRT001969)
- bta-mir-130b (MIRT003591)
- hsa-mir-23b-3p (MIRT004292)
- hsa-mir-34b-3p (MIRT004825)
- hsa-mir-562 (MIRT005024)
- hsa-mir-30a-5p (MIRT005167)
- hsa-mir-340-5p (MIRT005458)
- hsa-mir-449a (MIRT006346)
- hsa-mir-449b-5p (MIRT006351)
- hsa-mir-198 (MIRT006778)
- hsa-mir-130a-3p (MIRT007137)
- hsa-mir-133b (MIRT016691)
- hsa-mir-31-5p (MIRT035528)
- hsa-mir-1303 (MIRT035879)
- hsa-mir-320a (MIRT044529)
- hsa-mir-27a-3p (MIRT053148)
- hsa-mir-137 (MIRT053225)
- hsa-mir-410-3p (MIRT054232)
- hsa-mir-148a-3p (MIRT054388)
- hsa-mir-409-3p (MIRT437442)
- hsa-mir-101-3p (MIRT437858)
- hsa-mir-144-3p (MIRT438343)
- hsa-mir-7515 (MIRT438442)
- hsa-mir-218-5p (MIRT440251)
miRNA Products
- Search ViGene Biosciences for MET
Clone Products
- OriGene clones in human for MET
- OriGene ORF clones in human,mouse,rat for MET
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MET
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for MET
- R&D Systems cDNA Clones for MET (HGF R/c-MET)
Cell Line Products
-
Horizon Cell Lines for MET
-
ViGene Biosciences adenoviral particle packaged cDNA for MET gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MET gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MET gene
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-10363 VA6-13296) for MET
No data available for Transcription Factor Targets and HOMER Transcription for MET Gene
Localization for MET Gene
Subcellular locations from UniProtKB/Swiss-Prot for MET Gene
- Membrane; Single-pass type I membrane protein.
- Isoform 3: Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 5 |
| cytosol | 3 |
| cytoskeleton | 2 |
| endoplasmic reticulum | 2 |
| nucleus | 2 |
| endosome | 1 |
| lysosome | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| vacuole | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0009925 | basal plasma membrane | IDA | 15314156 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | NAS | 2819873 |
Pathways & Interactions for MET Gene
More details on SuperPathways for MET| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts |
.74
|
.66
.65
.61
.60
|
| 2 | GPCR Pathway |
.73
.62
|
.55
|
| 3 | ERK Signaling |
.61
.58
|
.49
|
| 4 | Nanog in Mammalian ESC Pluripotency |
.61
|
.48
|
| 5 | CREB Pathway |
.68
.68
|
Pathways by source for MET Gene
1 Cell Signaling Technology pathway for MET Gene
12 BioSystems pathways for MET Gene
5 Reactome pathways for MET Gene
5 GeneGo (Thomson Reuters) pathways for MET Gene
4 R&D Systems pathways for MET Gene
1 Tocris pathway for MET Gene
Interacting Proteins for MET Gene
Selected Interacting proteins:
P08581-MET_HUMAN
ENSP00000317272
for MET Gene via
MINT
STRING
UniProtKB
I2D
SIGNOR curated interactions for MET Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0007165 | signal transduction | TAS | 1846706 |
| GO:0007166 | cell surface receptor signaling pathway | NAS | 2819873 |
| GO:0007411 | axon guidance | TAS | -- |
| GO:0018108 | peptidyl-tyrosine phosphorylation | TAS | -- |
Drugs & Compounds for MET Gene
(122) Drugs for MET Gene - From: DrugBank, ClinicalTrials, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Crizotinib | Approved | Pharma | Inhibition, Biomarker, inhibitor, Target | C-MET/ALK inhibitor,potent and ATP-competitve, cMET Inhibitors, Kinase Inhibitors, Anaplastic lymphoma kinase (ALK) inhibitor, Potent c-MET/ALK inhibitor | 97 | |
| Cometriq | Approved November 2012 | Pharma | Inhibition, inhibitor, Biomarker | RTK, HGFR, VEGFR2, KIT, Flt3, and Tie-2 inhibitor, cMET Inhibitors | 0 | |
| cabozantinib | Approved | Pharma | inhibitor, Target, antagonist | Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 0 | |
| Cetuximab | Approved | Pharma | EGFR Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors | 717 | ||
| Docetaxel | Approved May 1996, Investigational | Pharma | Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes | 1859 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
||
| K 252a |
|
99533-80-9 |
|
|
||
| PF 04217903 mesylate |
|
956906-93-7 |
|
|
(5) Tocris Compounds for MET Gene
| Compound | Action | Cas Number |
|---|---|---|
| K 252a | Protein kinase inhibitor | 99533-80-9 |
| PF 04217903 mesylate | Highly selective MET inhibitor | 956906-93-7 |
| PHA 665752 | Potent and selective MET inhibitor | 477575-56-7 |
| SU 11274 | Selective inhibitor of MET kinase activity | 658084-23-2 |
| SU 5416 | VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3 | 204005-46-9 |
(22) ApexBio Compounds for MET Gene
| Compound | Action | Cas Number |
|---|---|---|
| (R)-Crizotinib | C-MET/ALK inhibitor,potent and ATP-competitve | 877399-52-5 |
| AMG-208 | C-Met inhibitor,potent and highly selective | 1002304-34-8 |
| AMG-458 | Potent c-Met inhibitor | 913376-83-7 |
| BMS-777607 | C-Met inhibitor, potent and selective | 1025720-94-8 |
| BMS-794833 | Met/VEGFR-2 inhibitor,potent and ATP-competitive | 1174046-72-0 |
| Cabozantinib (XL184, BMS-907351) | VEGFR2/Met/Ret/Kit/FLT//AXL inhibitor | 849217-68-1 |
| Cabozantinib malate (XL184) | MET andVEGF receptor2 inhibitor | 1140909-48-3 |
| EMD-1214063 | C-Met inhibitor,potent and selective | 1100598-32-0 |
| Foretinib (GSK1363089) | VEGF and HGF receptor inhibitor | 849217-64-7 |
| Golvatinib (E7050) | C-Met/VEGFR-2 inhibitor | 928037-13-2 |
| INCB28060 | C-Met inhibitor,ATP-competitive and novel | 1029712-80-8 |
| JNJ-38877605 | C-Met inhibitor,ATP-competitive | 943540-75-8 |
| MK-2461 | C-Met (WT/mutants) inhibitor | 917879-39-1 |
| NVP-BVU972 | C-Met inhibitor,potent and selective | 1185763-69-2 |
| PF-04217903 | C-Met inhibitor,selective and ATP-competitive | 956905-27-4 |
| PHA-665752 | C-Met inhibitor,potent and ATP-competitive | 477575-56-7 |
| SGX-523 | MET inibitor, highly selective, ATP-competitive | 1022150-57-7 |
| SU11274 | C-Met inhibitor,potent and selective | 658084-23-2 |
| SU5416 | VEGF receptor inhibitor and AHR agonist | 204005-46-9 |
| TAE226 (NVP-TAE226) | FAK inhibitor,potent and ATP-competitive | 761437-28-9 |
| Tivantinib (ARQ 197) | C-Met inhibitor,non-ATP-competitive | 905854-02-6 |
| ZM 323881 HCl | 193000-39-4 |
Transcripts for MET Gene
mRNA/cDNA for MET Gene
- (5) REFSEQ mRNAs :
- (31) Additional mRNA sequences :
- (254) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MET Gene
- Met proto-oncogene (hepatocyte growth factor receptor):
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for MET
-
Santa Cruz Biotechnology (SCBT) CRISPR for MET
- GenScript: Design CRISPR guide RNA sequences for MET
miRNA Products
- Search ViGene Biosciences for MET
Clone Products
- OriGene clones in human for MET
- OriGene ORF clones in human,mouse,rat for MET
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MET
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for MET
- R&D Systems cDNA Clones for MET (HGF R/c-MET)
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-10363 VA6-13296) for MET
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22a | · | 22b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: |
Expression for MET Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Satellite Cells Sacral Muscle Satellite Pool
- Muscle Satellite Cells Thoracic Muscle Satellite Pool
- Muscle Satellite Cells Cervical Muscle Satellite Pool
- Muscle satellite Cells Extraocular Muscles
- Muscle Progenitor Cells Tongue Muscles
- Brain (Nervous System)
-
Tooth (Integumentary System)
- Early Ameloblasts Dental Enamel
- Inner Enamel Epithelial Cells Dental Enamel
- Stellate Reticulum Cells Dental Core
- Outer Enamel Epithelial Cells Dental Enamel
-
Epithelial Cells
- Early Ameloblasts Dental Enamel
- Presumptive Podocytes Podocyte Layer
- Inner Enamel Epithelial Cells Dental Enamel
- Outer Enamel Epithelial Cells Dental Enamel
-
Somite (Muscoskeletal System)
- Muscle Progenitor Cells Tongue Muscles
- Muscle Progenitor Cells Cervical Ventrolateral Dermomyotome Lip
- Muscle Progenitor Cells Lumbar Ventrolateral Dermomyotome Lip
- Blood (Cardiovascular System)
-
Limb (Muscoskeletal System)
- Limb Muscle Progenitor Cells Hindlimb Myotome
- Limb Muscle Progenitor Cells Forelimb Myotome
- Inner Cell Mass (Early Embryonic Tissues)
-
Kidney (Urinary System)
- Presumptive Podocytes Podocyte Layer
- Spleen (Hematopoietic System)
- Bone (Muscoskeletal System)
- Liver (Hepatobiliary System)
This gene is overexpressed in Serum (29.7), Amniocyte (16.0), Breast (8.5), and Pancreas (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MET Gene
SOURCE GeneReport for Unigene cluster for MET Gene Hs.132966
mRNA Expression by UniProt/SwissProt for MET Gene
P08581-MET_HUMAN
Tissue specificity:
Expressed in normal hepatocytes as well as in epithelial cells lining the stomach, the small and the large intestine. Found also in basal keratinocytes of esophagus and skin. High levels are found in liver, gastrointestinal tract, thyroid and kidney. Also present in the brain.
Primer Products
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OriGene qPCR primer pairs for MET
No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for MET Gene
Orthologs for MET Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | MET 35 |
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| MET 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | MET 35 |
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| MET 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Met 35 |
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| Met 16 |
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| Met 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | MET 35 |
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| MET 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Met 35 |
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| oppossum (Monodelphis domestica) |
Mammalia | MET 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | MET 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MET 35 |
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| C-MET 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | MET 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | met 35 |
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| African clawed frog (Xenopus laevis) |
Amphibia | met-A 35 |
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| zebrafish (Danio rerio) |
Actinopterygii | Dr.18290 35 |
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| met 35 |
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| met 36 |
|
OneToOne | |||
| worm (Caenorhabditis elegans) |
Secernentea | F09A5.2 37 |
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| F09G2.1 37 |
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| F11E6.8 37 |
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| kin-16 37 |
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| kin-23 37 |
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| R09D1.12 37 |
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| R09D1.13 37 |
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| T14E8.1a 37 |
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| T14E8.1b 37 |
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| svh-2 36 |
|
OneToMany | |||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.8531 35 |
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| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
OneToMany |
- Species with no ortholog for MET:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for MET Gene
(94) SIMAP similar genes for MET Gene using alignment to 22 proteins:
- EPHA2
- FLT4
- ABL1
- tec
- PTK7
- KIF5B-ALK
- EPHA6
- EML4/ALK fusion
- EML4-ALK variant 7
- EML4-ALK variant 6
- BTK kinase deficient isoform 6
- IGF1R
- HCK
- LTK
- EPHA5
- FES
- ALK
- RYK
- SLC34A2/ROS1 fusion
- SLC34A2/ROS fusion
- JAK2
- EPHA3
- CD74/ROS fusion
- DKFZp434L0319
- FGFR1
- TPM3-ROS1
- SQSTM1-ALK
- SLC34A2-ROS1
- SDC4-ROS1_S4
- R34
- SDC4-ROS1_S4
- R32
- SDC4-ROS1_S2
- R32
- PTK2
- PPFIBP1-ALK
- LRIG3(NM_153377)-ROS1
- LRIG3(NM_001136051)-ROS1
- KIF5B-ALK_K17
- A20
- EZR-ROS1
- EML4-ALK
- CD74-ROS1_C6
- R32
- NTRK1
- CSK
- FLT1
- urf-ret
- TYRO3
- TXK
- KIF5B-RET(NM_020975)_K23
- R12
- KIF5B-RET(NM_020975)_K22
- R12
- KIF5B-RET(NM_020975)_K16
- R12
- KIF5B-RET(NM_020975)_K15
- R12
- KIF5B-RET(NM_020630)_K24
- R11
- KIF5B-RET(NM_020630)_K23
- R12
- KIF5B-RET(NM_020630)_K22
- R12
- KIF5B-RET(NM_020630)_K16
- R12
- KIF5B-RET(NM_020630)_K15
- R12
- DDR1
- CCDC6-RETc
- CCDC6-RETa
- AXL
- BTK kinase deficient isoform 2
- BTK
- RET
- TIE1
- FGFR4
- DKFZp686M05208
- FRK
- PLXNC1
- ERBB2
- TNK2
- EPHA10
- BLK
- MST1R
- TYK2
- FGR
- FGFR2
- MAP3K9
- EPHB6
- FGFR3
- PTK2B
- EGFR
- LIMK1
Variants for MET Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs35776110 | - | 116,700,043(+) | GGCTG(C/T)GTATG | intron-variant, reference, missense | |
| VAR_006286 | Renal cell carcinoma papillary (RCCP) | ||||
| VAR_006287 | Renal cell carcinoma papillary (RCCP) | ||||
| VAR_006288 | Renal cell carcinoma papillary (RCCP) | ||||
| VAR_006289 | Renal cell carcinoma papillary (RCCP) |
Residual Variation Intolerance Score:
22.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.48;
64.37% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for MET Gene
- Human Gene Mutation Database (HGMD)
- MET
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MET Gene
Disorders for MET Gene
(58) MalaCards diseases for MET Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| renal cell carcinoma, papillary |
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| deafness, autosomal recessive, 97 |
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| hereditary papillary renal cell carcinoma |
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| hepatocellular carcinoma |
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| autosomal recessive non-syndromic sensorineural deafness type dfnb |
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Search MET in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
MET_HUMAN- Hepatocellular carcinoma (HCC) [MIM:114550]: A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes. {ECO:0000269 PubMed:9927037}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Note=A common allele in the promoter region of the MET shows genetic association with susceptibility to autism in some families. Functional assays indicate a decrease in MET promoter activity and altered binding of specific transcription factor complexes.
- Note=Activation of MET after rearrangement with the TPR gene produces an oncogenic protein.
- Note=Defects in MET may be associated with gastric cancer.
- Note=MET activating mutations may be involved in the development of a highly malignant, metastatic syndrome known as cancer of unknown primary origin (CUP) or primary occult malignancy. Systemic neoplastic spread is generally a late event in cancer progression. However, in some instances, distant dissemination arises at a very early stage, so that metastases reach clinical relevance before primary lesions. Sometimes, the primary lesions cannot be identified in spite of the progresses in the diagnosis of malignancies.
- Renal cell carcinoma papillary (RCCP) [MIM:605074]: A subtype of renal cell carcinoma tending to show a tubulo-papillary architecture formed by numerous, irregular, finger-like projections of connective tissue. Renal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. {ECO:0000269 PubMed:10327054, ECO:0000269 PubMed:10417759, ECO:0000269 PubMed:10433944, ECO:0000269 PubMed:9140397, ECO:0000269 PubMed:9563489}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for MET
No data available for Genatlas for MET Gene
Publications for MET Gene
- A genetic variant that disrupts MET transcription is associated with autism. (PMID: 17053076) Campbell D.B. … Levitt P. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4 48 67
- A mutation of MET, encoding hepatocyte growth factor receptor, is associated with human DFNB97 hearing loss. (PMID: 25941349) Mujtaba G. … Naz S. (J. Med. Genet. 2015) 2 3
- c-Met overexpression contributes to the acquired apoptotic resistance of nonadherent ovarian cancer cells through a cross talk mediated by phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2. (PMID: 20126471) Tang M.K. … Wong A.S. (Neoplasia 2010) 3 23
- Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers. (PMID: 19096300) Onozato R. … Mitsudomi T. (J Thorac Oncol 2009) 3 23
- c-Met-targeted RNA interference inhibits growth and metastasis of glioma U251 cells in vitro. (PMID: 19165419) Chu S.H. … Qiu J.H. (J. Neurooncol. 2009) 3 23
Products for MET Gene
- Browse Small Molecules at EMD Millipore
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for MET
- EMD Millipore Purified and/or Recombinant MET Protein
- EMD Millipore Kits and Assays for MET
- EMD Millipore genomic analysis products
- R&D Systems Antibodies for MET (HGF R/c-MET)
- R&D Systems Proteins and Enzymes for MET (HGF R/c-MET)
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for MET (HGF R/c-MET)
- R&D Systems cDNA Clones for MET (HGF R/c-MET)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for MET
- Custom Assay ServicesOriGene ELISA Kits for MET
- OriGene Purified Proteins for MET
- Search Origene for MassSpec and Protein Over-expression Lysates for MET
- Origene Custom Protein Services for MET
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for MET
- Browse OriGene Inhibitory RNA Products For MET
- OriGene qPCR primer pairs for MET
- OriGene CRISPR knockouts for MET
- OriGene clones in human for MET
- OriGene ORF clones in human,mouse,rat for MET
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for MET
- GenScript Custom Assay Services for MET
- GenScript Custom overexpressing Cell Line Services for MET
- GenScript: Design CRISPR guide RNA sequences for MET
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for MET
- Cell Signaling Technology (CST) Antibodies for MET (Met)
- Cell Signaling Technology (CST) Sandwich ELISA Kits for MET (Met)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for MET
- Sino Biological Cell Lysates for MET
- Sino Biological Recombinant Proteins for MET
- 4000+ Proteins
- Search Sino Biological for antibodies, proteins & pathways
- Protein Production Services
- Transfection Reagents
- Protein A/G/L resins
- Isotyping reagents
- Novus Biologicals Antibodies for MET
- Novus Biologicals proteins and lysates for MET
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ProSpec Recombinant Proteins for MET
- Cloud-Clone Corp. Antibodies for MET
- Cloud-Clone Corp. Proteins for MET
- Cloud-Clone Corp Assay Kits for MET
- Invitrogen Antibodies for MET
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for MET
- Addgene plasmids for MET
- antibodies-online Antibodies for MET: See all 660
- antibodies-online Kits for MET: See all 1
- antibodies-online Proteins for MET: See all 29
- Search antibodies-online for peptides
- GeneTex MET antibody for MET
- GeneTex MET (Active) recombinant protein (GTX65521) for MET
- ViGene Biosciences adenoviral particle packaged cDNA for MET gene
- ViGene Biosciences lentiviral particle packaged cDNA for MET gene
- ViGene Biosciences lentiviral particle packaged cDNA for MET gene
- ViGene Biosciences ready-to-package AAV shRNAs for MET gene
- ViGene Biosciences ready-to-package AAV shRNAs for MET gene
- ViGene Biosciences ready-to-package AAV shRNAs for MET gene
- Search ViGene Biosciences for MET
- Search ViGene Biosciences for MET
- Santa Cruz Biotechnology (SCBT) Antibodies for MET
- Search Santa Cruz Biotechnology (SCBT) for MET siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MET
- Horizon Cell Lines for MET
Sources for MET Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon