Aliases for MET Gene
Aliases for MET Gene
External Ids for MET Gene
- HGNC: 7029
- Entrez Gene: 4233
- Ensembl: ENSG00000105976
- OMIM: 164860
- UniProtKB: P08581
Previous GeneCards Identifiers for MET Gene
- GC07P114790
- GC07P115853
- GC07P115866
- GC07P115906
- GC07P116099
- GC07P116312
- GC07P110678
Summaries for MET Gene
-
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]
-
Mesenchymal Epithelial Transition MET is a prototypical receptor tyrosine kinase. Its ligand is Hepatocyte Growth Factor (HGF). MET alterations are drivers of human cancer. Amplification and resulting overexpression has been reported in several cancers, and make the receptor's activity independent of HGF. Gene fusions also decouple kinase activity from the cell membrane and render it constitutively active. Finally, exclusion of the juxtamembrane (JM) domain of the kinase by "skipping" of exon 14 activates the kinase.
GeneCards Summary for MET Gene
MET (MET Proto-Oncogene, Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with MET include Renal Cell Carcinoma, Papillary, 1 and Deafness, Autosomal Recessive 97. Among its related pathways are RET signaling and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MST1R.
UniProtKB/Swiss-Prot for MET Gene
-
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis (By similarity).
-
Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells.
-
The MET receptor, also known as hepatocyte growth factor receptor (HGFR), is a proto-oncogenic receptor tyrosine kinase. The endogenous ligand for MET is hepatocyte growth factor/scatter factor (HGF), a disulfide-linked heterodimeric molecule.
Additional gene information for MET Gene
- Monarch Initiative
- Search for MET at DataMed
- Search for MET at HumanCyc
No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MET Gene
Genomics for MET Gene
GeneHancer (GH) Regulatory Elements for MET Gene
Regulatory Element Products
Genomic Locations for MET Gene
- chr7:116,672,390-116,798,386
- (GRCh38/hg38)
- Size:
- 125,997 bases
- Orientation:
- Plus strand
- chr7:116,312,444-116,438,440
- (GRCh37/hg19)
Genomic View for MET Gene
- Cytogenetic band:
-
- 7q31.2 by Ensembl
- 7q31.2 by Entrez Gene
- 7q31 by HGNC


RefSeq DNA sequence for MET Gene
Proteins for MET Gene
-
Protein details for MET Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P08581-MET_HUMAN
- Recommended name:
- Hepatocyte growth factor receptor
- Protein Accession:
- P08581
- A1L467
- B5A932
- E7EQ94
- O60366
- Q12875
- Q9UDX7
- Q9UPL8
Protein attributes for MET Gene
- Size:
- 1390 amino acids
- Molecular mass:
- 155541 Da
- Quaternary structure:
-
- Heterodimer made of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1. Interacts when phosphorylated with downstream effectors including STAT3, PIK3R1, SRC, PCLG1, GRB2 and GAB1. Interacts with SPSB1, SPSB2 and SPSB4 (By similarity). Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation. Interacts with GRB10. Interacts with PTPN1 and PTPN2. Interacts with LECT2; this interaction may have an antagonistic effect on receptor activation (PubMed:27334921). Interacts with HSP90AA1 and HSP90AB1; the interaction suppresses MET kinase activity (PubMed:26517842).
Three dimensional structures from OCA and Proteopedia for MET Gene
Protein Expression for MET Gene
Selected DME Specific Peptides for MET Gene
- P08581:
-
- IGRGHFGCVYHGTLLDND
- KANLSGG
- KSEMNVNM
- SPILTSGDSD
- VDTYYDDQLISCGSV
- FLWLKKRKQ
- DNINMAL
- SVRRLKET
- LHEHHIFLGATNYIYVLNEEDLQKVAE
- SGGVWKDN
- RDLAARN
- SCTLTLSEST
- APLEGGT
- GNENVLEIKGNDIDPEAVKGEVLKVGNKSCE
- LVQAVQHVVIGP
- EYKTGPV
- IDPEAVKGEVLKVGNKSCENIH
- LDSHPVS
- MNVNMKYQLPNFTA
- VLLGNESC
- KGDLTIANLGTSEGRF
- STVLGKVIVQPDQN
- AVLCTVP
- KPGAQLA
- LIGFGLQVA
- LPVKWMA
- GFMFLTDQSY
- SILECYTP
- NSSYFPDH
- KDRFINFFVGNTI
- GVFAQSKPDSAEPM
- ELVSRISAIFS
- CPDCVVSALG
- FVQCGWC
- HVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLD
- LGKVIVQPDQNFTGLI
- GECKEAL
- DEYRTEFTTA
- TVACQHRS
- PDQNFTGLIAGV
- EGSPLVVLPYMKHGDLRNFIRNE
- RGTCQRH
- HFQSCSQCL
- ELNIEWKQA
- CVAPYPSLLSS
- FIYFLTVQ
- DLLKLNS
- PVITSISP
- YREDPIV
- RPSFSELVS
- YQLPNFTAET
- IPLNGLGC
- FHTRIIRFCS
- CAFPIKY
- GGTLLTL
- SKYFDLIYVH
- QPEYCPD
- LKCTVGPA
- DDILFGVFAQSKPDSAEP
- FTVKVADFGLAR
- HGTTQYSTFSYVDP
- KQIKDLGSELVRYD
- SGTWTQQICLPAIYKVFP
- KLKIDLA
- NTLKCTVG
- KSDVWSFG
- HTPHLDRLVSARS
- EVMLKCWHP
- CGWDFGF
- FSYREDP
- DCSSKAN
- FLTDQSYIDVLP
- MKDFSHPNV
- KCVRSEEC
- NNKFDLKKT
- YVHNPVF
- CRQVQYPLTD
- FFNKIVNKNNV
- EMPLECILTEKR
- LECYTPAQ
- FRDSYPIKY
- EDPIVYEIHPTKSFISGGSTITG
- TGPVLEHP
- DLFMGQF
- DKEYYSV
- WMALESL
- GKNLNSVS
- EVFNILQAAYV
- FVHRDLA
- TCTLKSVS
- LHSISVRR
- VLLTSISTF
- FEKPVMIS
Post-translational modifications for MET Gene
- Autophosphorylated in response to ligand binding on Tyr-1234 and Tyr-1235 in the kinase domain leading to further phosphorylation of Tyr-1349 and Tyr-1356 in the C-terminal multifunctional docking site. Dephosphorylated by PTPRJ at Tyr-1349 and Tyr-1365. Dephosphorylated by PTPN1 and PTPN2.
- Ubiquitinated. Ubiquitination by CBL regulates MET endocytosis, resulting in decreasing plasma membrane receptor abundance, and in endosomal degradation and/or recycling of internalized receptors.
- Ubiquitination at isoforms=2962
- Glycosylation at isoforms=2, 345, isoforms=2, 3106, posLast=149149, isoforms=2, 3202, isoforms=2, 3399, posLast=405405, isoforms=2, 3607, isoforms=2, 3635, posLast=785785, posLast=879879, and isoforms=2930
Other Protein References for MET Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for MET (HGF R/c-MET)
- Cell Signaling Technology (CST) Antibodies for MET (Met)
-
Custom Antibody ServicesOriGene Antibodies for MET
- AM05937PU-N
- AM11001PU-N
- AM20218PU-N
- UM870082
- UM800082
- CF805996
- TA805996
- CF805796
- TA805796
- CF805795
- TA805795
- CF804960
- TA804960
- CF804927
- TA804927
- CF804884
- TA804884
- TA353755
- TA353754
- TA353331
- TA350824
- TA325692
- TA325691
- TA325690
- TA325689
- TA325688
- TA325687
- TA324322
- TA324321
- TA324320
- TA324319
- TA324318
- TA319135
- TA311752
- TA311751
- TA311750
- TA311749
- TA311748
- TA311746
- AP55921PU-S
- AP55921PU-N
- AP54995SU-N
- AP32044PU-N
- AP22713PU-N
- AP20841PU-N
- AP20840PU-N
- AP20720PU-N
- AP20719PU-N
- AP20332PU-N
- AP12648PU-N
- AP12647PU-N
- AP09516PU-S
- AP09516PU-N
- AP02738PU-S
- AP02738PU-N
- AP02729PU-S
- AP02729PU-N
- AP02494PU-S
- AP02494PU-N
- AP02485PU-S
- AP02485PU-N
- AM32986PU-N
- AM20493PU-N
- Novus Biologicals Antibodies for MET
-
Abcam antibodies for MET
-
Cloud-Clone Corp. Antibodies for MET
- Invitrogen Antibodies for MET
- antibodies-online: Search results for 730 available C-MET Antibodies ranked by validation data
- Compare Top C-MET Antibodies
-
Recommended
- 1 IP Antibody (anti-human)
- 3 IF Antibodies (anti-human)
- 4 DB Antibodies (anti-human)
- 16 IHC Antibodies (anti-human)
- 42 FACS Antibodies (anti-human)
- 46 IHC (p) Antibodies (anti-human)
- 60 IF (p) Antibodies (anti-human)
- 488 WB Antibodies (anti-human)
- 1 IP Antibody (anti-rat)
- 1 FACS Antibody (anti-rat)
- 9 IHC Antibodies (anti-rat)
- 60 IF (p) Antibodies (anti-rat)
- 144 WB Antibodies (anti-rat)
- 1 IP Antibody (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 10 IHC Antibodies (anti-mouse)
- 60 IF (p) Antibodies (anti-mouse)
- 196 WB Antibodies (anti-mouse)
- 1 Neut Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 3 IF Antibodies (anti-human)
- 4 DB Antibodies (anti-human)
- 16 IHC Antibodies (anti-human)
- 42 FACS Antibodies (anti-human)
- 46 IHC (p) Antibodies (anti-human)
- 60 IF (p) Antibodies (anti-human)
- 488 WB Antibodies (anti-human)
- 1 IP Antibody (anti-rat)
- 1 FACS Antibody (anti-rat)
- 9 IHC Antibodies (anti-rat)
- 60 IF (p) Antibodies (anti-rat)
- 144 WB Antibodies (anti-rat)
- 1 IP Antibody (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 10 IHC Antibodies (anti-mouse)
- 60 IF (p) Antibodies (anti-mouse)
- 196 WB Antibodies (anti-mouse)
- 1 Neut Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 3 IF Antibodies (anti-human)
- 4 DB Antibodies (anti-human)
- 16 IHC Antibodies (anti-human)
- 42 FACS Antibodies (anti-human)
- 46 IHC (p) Antibodies (anti-human)
- 60 IF (p) Antibodies (anti-human)
- 488 WB Antibodies (anti-human)
- 1 IP Antibody (anti-rat)
- 1 FACS Antibody (anti-rat)
- 9 IHC Antibodies (anti-rat)
- 60 IF (p) Antibodies (anti-rat)
- 144 WB Antibodies (anti-rat)
- 1 IP Antibody (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 10 IHC Antibodies (anti-mouse)
- 60 IF (p) Antibodies (anti-mouse)
- 196 WB Antibodies (anti-mouse)
- 1 Neut Antibody (anti-human)
- GeneTex MET antibody for MET
-
ProteoGenix Antibodies for MET
- 26464-met-polyclonal-antibody
- 26463-met-polyclonal-antibody
- 26462-phospho-met-y1003-polyclonal-antibody
- 26461-phospho-met-y1356-polyclonal-antibody
- 23043-met-polyclonal-antibody
- 23042-met-polyclonal-antibody
- 23041-met-polyclonal-antibody
- 21632-phospho-met-y1349-polyclonal-antibody
- 21631-phospho-met-y1234-polyclonal-antibody
- ProteoGenix Custom Antibody Production Services (Monoclonal/ Polyclonal/ Phage display/Ascites & CS)
- ProteoGenix Custom Monoclonal Antibody Humanization Services (Drug discovery services, Stable cell line, ADCC)
-
Santa Cruz Biotechnology (SCBT) Antibodies for MET
- Sino Biological Antibodies for MET
Protein Products
- R&D Systems Proteins and Enzymes for MET (HGF R/c-MET)
-
OriGene Purified Proteins for MET
- Search Origene for MassSpec and Protein Over-expression Lysates for MET
- Origene Custom Protein Services for MET
- Sino Biological Recombinant Proteins for MET
- Sino Biological Cell Lysates for MET
- ProSpec Recombinant Proteins for MET
-
Cloud-Clone Corp. Proteins for MET
- GeneTex Proteins for MET
-
ProSci Proteins for MET
-
Abcam proteins for MET
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for MET
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for MET (HGF R/c-MET)
- Cell Signaling Technology (CST) Sandwich ELISA Kits for MET (Met)
-
Cloud-Clone Corp. Assay Kits for MET
Domains & Families for MET Gene
Gene Families for MET Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Enzymes
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for MET Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MET Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P08581UniProtKB/Swiss-Prot:
MET_HUMAN :- The kinase domain is involved in SPSB1 binding.
- Belongs to the protein kinase superfamily. Tyr protein kinase family.
- Domain:
-
- The kinase domain is involved in SPSB1 binding.
- The beta-propeller Sema domain mediates binding to HGF.
- Family:
-
- Belongs to the protein kinase superfamily. Tyr protein kinase family.
Function for MET Gene
Molecular function for MET Gene
- GENATLAS Biochemistry:
- met proto-oncogene,transmembrane receptor (tyrosine kinase) for hepatocyte growth factor,with two alternatively spliced isoforms,important regulator of cell proliferation and differentiation,organ regeneration,embryogenesis and tumorogenesis,amplified in the glioblastomas,mutated in childhood hepatocellular carcinomas and hereditary papillary renal carcinomas (role in the acceleration of carcinogenesis),paralog to MST1R
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity.
- UniProtKB/Swiss-Prot Function:
- Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis (By similarity).
- UniProtKB/Swiss-Prot Function:
- Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells.
Enzyme Numbers (IUBMB) for MET Gene
Phenotypes From GWAS Catalog for MET Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004672 | protein kinase activity | IEA | -- |
GO:0004713 | protein tyrosine kinase activity | TAS | -- |
GO:0004714 | transmembrane receptor protein tyrosine kinase activity | IEA | -- |
GO:0005008 | hepatocyte growth factor-activated receptor activity | TAS | 10871856 |
Phenotypes for MET Gene
- MGI mutant phenotypes for MET:
-
inferred from 21 alleles
- nervous system phenotype
- normal phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- embryo phenotype
- renal/urinary system phenotype
- liver/biliary system phenotype
- craniofacial phenotype
- no phenotypic analysis
- limbs/digits/tail phenotype
- GenomeRNAi human phenotypes for MET:
-
- Increased shRNA abundance (Z-score > 2)
- Transferrin accumulation in the perinuclear area
- Decreased substrate adherent cell growth
- Decreased shRNA abundance (Z-score < -2)
- Decreased cell migration
- Weakly decreased NFAT1-GFP nuclear translocation
- Increased cell viability after pRB stimulation
- Increased mitotic index
- Increased simian virus 40 (SV40) infection
- Decreased telomerase activity
- Decreased viability after Chlamydia trachomatis serovar L2 infection and TNF-alpha/CHX stimulation
- Decreased viability in Von Hippel-Lindau (VHL) (-/-) cell line
Animal Models for MET Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for MET gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MET gene
- Search ViGene Biosciences for MET
CRISPR Products
-
OriGene CRISPR knockouts for MET
- genomics-online: gRNA clones - Search results for 125 available C-MET gene related products
- Overview of 125 available C-MET gene related products
-
Recommended
- pGFP-C-shLenti
- pRFP-C-RS
- pPB-His-GST
- pPB-C-His
- pPB-His-MBP
- pPB-N-His
- pCMV6-Entry
- pGFP-V-RS
- pCMV6-XL5
- pGFP-C-shLenti
- pRFP-C-RS
- pPB-His-GST
- pPB-C-His
- pPB-His-MBP
- pPB-N-His
- pCMV6-Entry
- pGFP-V-RS
- pCMV6-XL5
- pGFP-C-shLenti
- pRFP-C-RS
- pPB-His-GST
- pPB-C-His
- pPB-His-MBP
- pPB-N-His
- pCMV6-Entry
- pGFP-V-RS
- pCMV6-XL5
- Applied Biological Materials CRISPR for MET
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MET
- GenScript: Design CRISPR guide RNA sequences for MET
miRNA for MET Gene
- miRTarBase miRNAs that target MET
-
- hsa-mir-206 (MIRT000185)
- hsa-mir-34c-5p (MIRT000757)
- hsa-mir-34b-5p (MIRT000758)
- hsa-mir-34a-5p (MIRT000759)
- hsa-mir-1-3p (MIRT001357)
- hsa-mir-199a-3p (MIRT001969)
- bta-mir-130b (MIRT003591)
- hsa-mir-23b-3p (MIRT004292)
- hsa-mir-34b-3p (MIRT004825)
- hsa-mir-562 (MIRT005024)
- hsa-mir-30a-5p (MIRT005167)
- hsa-mir-340-5p (MIRT005458)
- hsa-mir-449a (MIRT006346)
- hsa-mir-449b-5p (MIRT006351)
- hsa-mir-198 (MIRT006778)
- hsa-mir-130a-3p (MIRT007137)
- hsa-mir-133b (MIRT016691)
- hsa-mir-31-5p (MIRT035528)
- hsa-mir-1303 (MIRT035879)
- hsa-mir-320a (MIRT044529)
- hsa-mir-27a-3p (MIRT053148)
- hsa-mir-137 (MIRT053225)
- hsa-mir-410-3p (MIRT054232)
- hsa-mir-148a-3p (MIRT054388)
- hsa-mir-449c-5p (MIRT319319)
- hsa-mir-409-3p (MIRT437442)
- hsa-mir-101-3p (MIRT437858)
- hsa-mir-144-3p (MIRT438343)
- hsa-mir-7515 (MIRT438442)
- hsa-mir-218-5p (MIRT440251)
- hsa-mir-433-3p (MIRT731338)
- hsa-mir-139-5p (MIRT732083)
- hsa-mir-27b-3p (MIRT732479)
- hsa-mir-34a-3p (MIRT733070)
- hsa-mir-1-5p (MIRT734958)
- hsa-mir-144-5p (MIRT735298)
- hsa-mir-1257 (MIRT790064)
- hsa-mir-1262 (MIRT790069)
- hsa-mir-425-5p (MIRT790393)
- hsa-mir-4506 (MIRT790503)
- hsa-mir-4701-3p (MIRT790571)
- hsa-mir-545-5p (MIRT790733)
- hsa-mir-6736-5p (MIRT790905)
- hsa-mir-802 (MIRT791134)
miRNA Products
- Search ViGene Biosciences for MET
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for MET
- Browse OriGene Inhibitory RNA Products For MET
- genomics-online: shRNA clones - Search results for 125 available C-MET gene related products
- Overview of 125 available C-MET gene related products
-
Recommended
- pGFP-C-shLenti
- pRFP-C-RS
- pPB-His-GST
- pPB-C-His
- pPB-His-MBP
- pPB-N-His
- pCMV6-Entry
- pGFP-V-RS
- pCMV6-XL5
- pGFP-C-shLenti
- pRFP-C-RS
- pPB-His-GST
- pPB-C-His
- pPB-His-MBP
- pPB-N-His
- pCMV6-Entry
- pGFP-V-RS
- pCMV6-XL5
- pGFP-C-shLenti
- pRFP-C-RS
- pPB-His-GST
- pPB-C-His
- pPB-His-MBP
- pPB-N-His
- pCMV6-Entry
- pGFP-V-RS
- pCMV6-XL5
-
ViGene Biosciences ready-to-package AAV shRNAs for MET gene
Clone Products
- Sino Biological Human cDNA Clone for MET
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for MET
- genomics-online: cdna clones - Search results for 125 available C-MET gene related products
- Overview of 125 available C-MET gene related products
-
Recommended
- pGFP-C-shLenti
- pRFP-C-RS
- pPB-His-GST
- pPB-C-His
- pPB-His-MBP
- pPB-N-His
- pCMV6-Entry
- pGFP-V-RS
- pCMV6-XL5
- pGFP-C-shLenti
- pRFP-C-RS
- pPB-His-GST
- pPB-C-His
- pPB-His-MBP
- pPB-N-His
- pCMV6-Entry
- pGFP-V-RS
- pCMV6-XL5
- pGFP-C-shLenti
- pRFP-C-RS
- pPB-His-GST
- pPB-C-His
- pPB-His-MBP
- pPB-N-His
- pCMV6-Entry
- pGFP-V-RS
- pCMV6-XL5
- orf clones - Search results for 125 available C-MET gene related products
- Overview of 125 available C-MET gene related products
-
Recommended
- pGFP-C-shLenti
- pRFP-C-RS
- pPB-His-GST
- pPB-C-His
- pPB-His-MBP
- pPB-N-His
- pCMV6-Entry
- pGFP-V-RS
- pCMV6-XL5
- pGFP-C-shLenti
- pRFP-C-RS
- pPB-His-GST
- pPB-C-His
- pPB-His-MBP
- pPB-N-His
- pCMV6-Entry
- pGFP-V-RS
- pCMV6-XL5
- pGFP-C-shLenti
- pRFP-C-RS
- pPB-His-GST
- pPB-C-His
- pPB-His-MBP
- pPB-N-His
- pCMV6-Entry
- pGFP-V-RS
- pCMV6-XL5
- Applied Biological Materials Clones for MET
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for MET (HGF R/c-MET)
Cell Line Products
-
Horizon Cell Lines for MET
-
ViGene Biosciences adenoviral particle packaged cDNA for MET gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MET gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MET gene
No data available for Transcription Factor Targets and HOMER Transcription for MET Gene
Localization for MET Gene
Subcellular locations from UniProtKB/Swiss-Prot for MET Gene
- Membrane; Single-pass type I membrane protein.
- Isoform 3: Secreted.
- Cytosol (3)
- Plasma membrane (3)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005622 | intracellular | IEA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | TAS | 1846706 |
GO:0009925 | basal plasma membrane | IDA | 15314156 |
Pathways & Interactions for MET Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
.92
|
2 | Apoptotic Pathways in Synovial Fibroblasts |
.74
|
.66
.65
.61
.60
|
3 | GPCR Pathway |
.73
.62
|
.55
|
4 | PI3K/AKT activation |
.89
|
|
5 | MET promotes cell motility |
.45
|
Pathways by source for MET Gene
1 Cell Signaling Technology pathway for MET Gene
14 BioSystems pathways for MET Gene
77 Reactome pathways for MET Gene
5 GeneGo (Thomson Reuters) pathways for MET Gene
4 R&D Systems pathways for MET Gene
1 Tocris pathway for MET Gene
Interacting Proteins for MET Gene
SIGNOR curated interactions for MET Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | TAS | -- |
GO:0001886 | endothelial cell morphogenesis | IDA | 14500721 |
GO:0006468 | protein phosphorylation | IEA | -- |
GO:0007165 | signal transduction | TAS | 1846706 |
GO:0007166 | cell surface receptor signaling pathway | NAS | 2819873 |
Drugs & Compounds for MET Gene
(132) Drugs for MET Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Crizotinib | Approved | Pharma | Target, inhibitor, Inhibition, Biomarker | C-MET/ALK inhibitor,potent and ATP-competitve, Potent c-MET/ALK inhibitor, cMET Inhibitors, Kinase Inhibitors, Anaplastic lymphoma kinase (ALK) inhibitor | 107 | |
cabozantinib | Approved, Investigational | Pharma | Target, antagonist, inhibitor | Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 0 | |
Cometriq | Approved November 2012 | Pharma | Inhibition, inhibitor, Biomarker | RTK, HGFR, VEGFR2, KIT, Flt3, and Tie-2 inhibitor, cMET Inhibitors | 0 | |
Gefitinib | Approved, Investigational | Pharma | EGFR Inhibitors, Kinase Inhibitors, Epidermal growth factor receptor (EGFR) inhibitors | 374 | ||
Cetuximab | Approved | Pharma | EGFR Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors | 784 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Full agonist, Agonist | 58-64-0 |
|
||
PF 04217903 mesylate |
|
956906-93-7 |
|
|
(5) Tocris Compounds for MET Gene
Compound | Action | Cas Number |
---|---|---|
Norleual | Highly potent HGF/c-MET inhibitor; also AT4 antagonist | 334994-34-2 |
PF 04217903 mesylate | Highly selective MET inhibitor | 956906-93-7 |
PHA 665752 | Potent and selective MET inhibitor | 477575-56-7 |
SGX 523 | Selective and potent c-MET kinase inhibitor | 1022150-57-7 |
SU 11274 | Selective inhibitor of MET kinase activity | 658084-23-2 |
(33) ApexBio Compounds for MET Gene
Compound | Action | Cas Number |
---|---|---|
(R)-Crizotinib | C-MET/ALK inhibitor,potent and ATP-competitve | 877399-52-5 |
Altiratinib | c-MET/TIE-2/VEGFR inhibitor | 1345847-93-9 |
AMG-208 | C-Met inhibitor,potent and highly selective | 1002304-34-8 |
AMG-458 | Potent c-Met inhibitor | 913376-83-7 |
BMS-777607 | C-Met inhibitor, potent and selective | 1025720-94-8 |
BMS-794833 | Met/VEGFR-2 inhibitor,potent and ATP-competitive | 1174046-72-0 |
BMS-817378 | Potent ATP competitive inhibitor of Met/VEGFR2 | 1174161-69-3 |
Cabozantinib (XL184, BMS-907351) | VEGFR2/Met/Ret/Kit/FLT//AXL inhibitor | 849217-68-1 |
Cabozantinib malate (XL184) | MET andVEGF receptor2 inhibitor | 1140909-48-3 |
c-Met inhibitor 1 | Inhibitor of the c-Met receptor | 1357072-61-7 |
EMD-1214063 | C-Met inhibitor,potent and selective | 1100598-32-0 |
Foretinib (GSK1363089) | VEGF and HGF receptor inhibitor | 849217-64-7 |
Golvatinib (E7050) | C-Met/VEGFR-2 inhibitor | 928037-13-2 |
INCB28060 | C-Met inhibitor,ATP-competitive and novel | 1029712-80-8 |
JNJ-38877605 | C-Met inhibitor,ATP-competitive | 943540-75-8 |
LY2801653 | MET inhibitor | 1206799-15-6 |
LY2801653 dihydrochloride | MET inhibitor | 1206801-37-7 |
MGCD-265 | Met/Flt/Flk/Ron/Tie-2 inhibitor | 875337-44-3 |
MK-2461 | C-Met (WT/mutants) inhibitor | 917879-39-1 |
MK-8033 | C-MET inhibitor | 1001917-37-8 |
MK-8033 hydrochloride | C-Met/Ron inhibitor | 1283000-43-0 |
NPS-1034 | MET inhibitor | 1221713-92-3 |
NVP-BVU972 | C-Met inhibitor,potent and selective | 1185763-69-2 |
PF-04217903 | C-Met inhibitor,selective and ATP-competitive | 956905-27-4 |
PF-04217903 methanesulfonate | C-Met inhibitor,selective and ATP-competitive | 956906-93-7 |
PHA-665752 | C-Met inhibitor,potent and ATP-competitive | 477575-56-7 |
SGX-523 | MET inibitor, highly selective, ATP-competitive | 1022150-57-7 |
SU11274 | C-Met inhibitor,potent and selective | 658084-23-2 |
SU5416 | VEGF receptor inhibitor and AHR agonist | 204005-46-9 |
TAE226 (NVP-TAE226) | FAK inhibitor,potent and ATP-competitive | 761437-28-9 |
Tivantinib (ARQ 197) | C-Met inhibitor,non-ATP-competitive | 905854-02-6 |
Tyrosine kinase inhibitor | Tyrosine-kinase inhibitor | 1021950-26-4 |
ZM 323881 HCl | 193000-39-4 |
Transcripts for MET Gene
mRNA/cDNA for MET Gene
- (6) REFSEQ mRNAs :
- (31) Additional mRNA sequences :
- (254) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MET Gene
- Met proto-oncogene (hepatocyte growth factor receptor):
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for MET
- genomics-online: gRNA clones - Search results for 125 available C-MET gene related products
- Overview of 125 available C-MET gene related products
-
Recommended
- pGFP-C-shLenti
- pRFP-C-RS
- pPB-His-GST
- pPB-C-His
- pPB-His-MBP
- pPB-N-His
- pCMV6-Entry
- pGFP-V-RS
- pCMV6-XL5
- pGFP-C-shLenti
- pRFP-C-RS
- pPB-His-GST
- pPB-C-His
- pPB-His-MBP
- pPB-N-His
- pCMV6-Entry
- pGFP-V-RS
- pCMV6-XL5
- pGFP-C-shLenti
- pRFP-C-RS
- pPB-His-GST
- pPB-C-His
- pPB-His-MBP
- pPB-N-His
- pCMV6-Entry
- pGFP-V-RS
- pCMV6-XL5
- Applied Biological Materials CRISPR for MET
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MET
- GenScript: Design CRISPR guide RNA sequences for MET
miRNA Products
- Search ViGene Biosciences for MET
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for MET
- Browse OriGene Inhibitory RNA Products For MET
- genomics-online: shRNA clones - Search results for 125 available C-MET gene related products
- Overview of 125 available C-MET gene related products
-
Recommended
- pGFP-C-shLenti
- pRFP-C-RS
- pPB-His-GST
- pPB-C-His
- pPB-His-MBP
- pPB-N-His
- pCMV6-Entry
- pGFP-V-RS
- pCMV6-XL5
- pGFP-C-shLenti
- pRFP-C-RS
- pPB-His-GST
- pPB-C-His
- pPB-His-MBP
- pPB-N-His
- pCMV6-Entry
- pGFP-V-RS
- pCMV6-XL5
- pGFP-C-shLenti
- pRFP-C-RS
- pPB-His-GST
- pPB-C-His
- pPB-His-MBP
- pPB-N-His
- pCMV6-Entry
- pGFP-V-RS
- pCMV6-XL5
-
ViGene Biosciences ready-to-package AAV shRNAs for MET gene
Clone Products
- Sino Biological Human cDNA Clone for MET
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for MET
- genomics-online: cdna clones - Search results for 125 available C-MET gene related products
- Overview of 125 available C-MET gene related products
-
Recommended
- pGFP-C-shLenti
- pRFP-C-RS
- pPB-His-GST
- pPB-C-His
- pPB-His-MBP
- pPB-N-His
- pCMV6-Entry
- pGFP-V-RS
- pCMV6-XL5
- pGFP-C-shLenti
- pRFP-C-RS
- pPB-His-GST
- pPB-C-His
- pPB-His-MBP
- pPB-N-His
- pCMV6-Entry
- pGFP-V-RS
- pCMV6-XL5
- pGFP-C-shLenti
- pRFP-C-RS
- pPB-His-GST
- pPB-C-His
- pPB-His-MBP
- pPB-N-His
- pCMV6-Entry
- pGFP-V-RS
- pCMV6-XL5
- orf clones - Search results for 125 available C-MET gene related products
- Overview of 125 available C-MET gene related products
-
Recommended
- pGFP-C-shLenti
- pRFP-C-RS
- pPB-His-GST
- pPB-C-His
- pPB-His-MBP
- pPB-N-His
- pCMV6-Entry
- pGFP-V-RS
- pCMV6-XL5
- pGFP-C-shLenti
- pRFP-C-RS
- pPB-His-GST
- pPB-C-His
- pPB-His-MBP
- pPB-N-His
- pCMV6-Entry
- pGFP-V-RS
- pCMV6-XL5
- pGFP-C-shLenti
- pRFP-C-RS
- pPB-His-GST
- pPB-C-His
- pPB-His-MBP
- pPB-N-His
- pCMV6-Entry
- pGFP-V-RS
- pCMV6-XL5
- Applied Biological Materials Clones for MET
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for MET (HGF R/c-MET)
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22a | · | 22b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP3: |
Expression for MET Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Satellite Cells Sacral Muscle Satellite Pool
- Muscle Satellite Cells Thoracic Muscle Satellite Pool
- Muscle Satellite Cells Cervical Muscle Satellite Pool
- Muscle satellite Cells Extraocular Muscles
- Muscle Progenitor Cells Tongue Muscles
- Brain (Nervous System)
-
Tooth (Integumentary System)
- Early Ameloblasts Dental Enamel
- Inner Enamel Epithelial Cells Dental Enamel
- Stellate Reticulum Cells Dental Core
- Outer Enamel Epithelial Cells Dental Enamel
-
Epithelial Cells
- Early Ameloblasts Dental Enamel
- Presumptive Podocytes Podocyte Layer
- Inner Enamel Epithelial Cells Dental Enamel
- Outer Enamel Epithelial Cells Dental Enamel
-
Somite (Muscoskeletal System)
- Muscle Progenitor Cells Tongue Muscles
- Muscle Progenitor Cells Cervical Ventrolateral Dermomyotome Lip
- Muscle Progenitor Cells Lumbar Ventrolateral Dermomyotome Lip
- Blood (Cardiovascular System)
-
Limb (Muscoskeletal System)
- Limb Muscle Progenitor Cells Hindlimb Myotome
- Limb Muscle Progenitor Cells Forelimb Myotome
- Inner Cell Mass (Early Embryonic Tissues)
-
Kidney (Urinary System)
- Presumptive Podocytes Podocyte Layer
- Spleen (Hematopoietic System)
- Bone (Muscoskeletal System)
- Liver (Hepatobiliary System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MET Gene
NURSA nuclear receptor signaling pathways regulating expression of MET Gene:
METSOURCE GeneReport for Unigene cluster for MET Gene:
Hs.132966mRNA Expression by UniProt/SwissProt for MET Gene:
P08581-MET_HUMANEvidence on tissue expression from TISSUES for MET Gene
- Liver(4.6)
- Nervous system(4.6)
- Lung(3.4)
- Intestine(3.2)
- Kidney(2.9)
- Heart(2.4)
- Muscle(2.4)
- Stomach(2.4)
- Lymph node(2.3)
- Skin(2.3)
- Thyroid gland(2.3)
- Blood(2.2)
- Pancreas(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for MET Gene
- ectoderm
- endoderm
- mesoderm
- cardiovascular
- digestive
- immune
- integumentary
- nervous
- reproductive
- skeletal muscle
- skeleton
- urinary
- brain
- cerebellum
- cranial nerve
- ear
- eye
- head
- inner ear
- middle ear
- mouth
- outer ear
- salivary gland
- skull
- breast
- esophagus
- kidney
- liver
- spleen
- testicle
- digit
- finger
- foot
- hand
- lower limb
- nail
- toe
- upper limb
- blood vessel
- coagulation system
- peripheral nerve
- peripheral nervous system
- skin
Primer Products
-
OriGene qPCR primer pairs for MET
- genomics-online: primer clones - Search results for 125 available C-MET gene related products
- Overview of 125 available C-MET gene related products
-
Recommended
- pGFP-C-shLenti
- pRFP-C-RS
- pPB-His-GST
- pPB-C-His
- pPB-His-MBP
- pPB-N-His
- pCMV6-Entry
- pGFP-V-RS
- pCMV6-XL5
- pGFP-C-shLenti
- pRFP-C-RS
- pPB-His-GST
- pPB-C-His
- pPB-His-MBP
- pPB-N-His
- pCMV6-Entry
- pGFP-V-RS
- pCMV6-XL5
- pGFP-C-shLenti
- pRFP-C-RS
- pPB-His-GST
- pPB-C-His
- pPB-His-MBP
- pPB-N-His
- pCMV6-Entry
- pGFP-V-RS
- pCMV6-XL5
No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for MET Gene
Orthologs for MET Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | MET 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | MET 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | MET 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Met 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Met 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | MET 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | MET 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | C-MET 34 |
|
OneToOne | |
MET 33 |
|
||||
lizard (Anolis carolinensis) |
Reptilia | MET 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | met 33 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | met-A 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | met 33 34 |
|
||
Dr.18290 33 |
|
||||
worm (Caenorhabditis elegans) |
Secernentea | F11E6.8 35 |
|
|
|
T14E8.1a 35 |
|
|
|||
T14E8.1b 35 |
|
|
|||
kin-16 35 |
|
|
|||
kin-23 35 |
|
|
|||
R09D1.12 35 |
|
|
|||
F09A5.2 35 |
|
|
|||
F09G2.1 35 |
|
|
|||
R09D1.13 35 |
|
|
|||
svh-2 34 |
|
OneToMany | |||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany | |
sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.8531 33 |
|
- Species where no ortholog for MET was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for MET Gene
(94) SIMAP similar genes for MET Gene using alignment to 22 proteins:
- EPHA2
- FLT4
- ABL1
- tec
- PTK7
- KIF5B-ALK
- EPHA6
- EML4/ALK fusion
- EML4-ALK variant 7
- EML4-ALK variant 6
- BTK kinase deficient isoform 6
- IGF1R
- HCK
- LTK
- EPHA5
- FES
- ALK
- RYK
- SLC34A2/ROS1 fusion
- SLC34A2/ROS fusion
- JAK2
- EPHA3
- CD74/ROS fusion
- DKFZp434L0319
- FGFR1
- TPM3-ROS1
- SQSTM1-ALK
- SLC34A2-ROS1
- SDC4-ROS1_S4
- R34
- SDC4-ROS1_S4
- R32
- SDC4-ROS1_S2
- R32
- PTK2
- PPFIBP1-ALK
- LRIG3(NM_153377)-ROS1
- LRIG3(NM_001136051)-ROS1
- KIF5B-ALK_K17
- A20
- EZR-ROS1
- EML4-ALK
- CD74-ROS1_C6
- R32
- NTRK1
- CSK
- FLT1
- urf-ret
- TYRO3
- TXK
- KIF5B-RET(NM_020975)_K23
- R12
- KIF5B-RET(NM_020975)_K22
- R12
- KIF5B-RET(NM_020975)_K16
- R12
- KIF5B-RET(NM_020975)_K15
- R12
- KIF5B-RET(NM_020630)_K24
- R11
- KIF5B-RET(NM_020630)_K23
- R12
- KIF5B-RET(NM_020630)_K22
- R12
- KIF5B-RET(NM_020630)_K16
- R12
- KIF5B-RET(NM_020630)_K15
- R12
- DDR1
- CCDC6-RETc
- CCDC6-RETa
- AXL
- BTK kinase deficient isoform 2
- BTK
- RET
- TIE1
- FGFR4
- DKFZp686M05208
- FRK
- PLXNC1
- ERBB2
- TNK2
- EPHA10
- BLK
- MST1R
- TYK2
- FGR
- FGFR2
- MAP3K9
- EPHB6
- FGFR3
- PTK2B
- EGFR
- LIMK1