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MET Gene

protein-coding GIFtS: 75

GC07P116099

met proto-oncogene (hepatocyte growth factor receptor)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AUTS9 ^², ⁵
EC 2.7.10.1 ^³
HGFR ^¹, ²
OTTHUMP00000069168 ^²
RCCP2 ^¹, ²
c-Met ^², ³

Descriptions
HGF receptor ^², ³
HGF/SF receptor ^³
Met proto-oncogene tyrosine kinase ^², ³
SF receptor ^², ³
Scatter factor receptor ^², ³
met proto-oncogene ^²
met proto-oncogene (hepatocyte growth factor receptor) ^²
oncogene MET ^²

External Ids
HGNC: 7029¹
Entrez Gene: 4233²
UniProtKB: P08581³
Ensembl: ENSG00000105976⁷

Search outside databases for aliases for MET gene

Previous GC identifers: GC07P114790 GC07P115853 GC07P115866 GC07P115906

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MET:

The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase

activity. The primary single chain precursor protein is post-translationally cleaved to produce

the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various

mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants

encoding different isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: MET_HUMAN, P08581

Function: Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase

activity. Functions in cell proliferation, scattering, morphogenesis and survival

Gene Wiki entry for MET (C-Met)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MET gene

Entrez Gene cytogenetic band: 7q31 Ensembl cytogenetic band: 7q31.2 HGNC cytogenetic band: 7q31

MET Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P116099: (about GC identifiers)

Start:	116,099,682 bp from pter
End:	116,225,676 bp from pter
Size:	125,995 bases
Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 115,707,906-115,833,890

RefSeq DNA sequence:

NC_000007.12 NT_007933.14 NT_079596.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: MET_HUMAN, P08581 (See protein sequence)

Recommended Name: Hepatocyte growth factor receptor precursor

Size: 1390 amino acids; 155527 Da

Subunit: Heterodimer formed of an alpha chain (50 kDa) and a beta chain (145 kDa) which are

disulfide linked. Binds PLXNB1 and GRB2. Interacts with SPSB1, SPSB2 and SPSB4 (By similarity).

Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2.

Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs

in the presence and in the absence of HGF, however HGF treatment has a positive effect on this

interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth

factor-induced cell proliferation

Subcellular location: Membrane; Single-pass type I membrane protein

PDB structures from and Proteopedia :

1FYR (3D)

1R0P (3D)

1R1W (3D)

1SHY (3D)

1SSL (3D)

1UX3 (3D)

2G15 (3D)

2RFN (3D)

2RFS (3D)

2UZX (3D)

2UZY (3D)

2WD1 (3D)

3BUX (3D)

3CE3 (3D)

3CTH (3D)

3CTJ (3D)

3EFJ (3D)

3EFK (3D)

3F66 (3D)

3F82 (3D)

Secondary accessions: O60366 Q12875 Q9UDX7 Q9UPL8

Alternative splicing: 2 isoforms: P08581-1 P08581-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_000236.2 NP_001120972.1

ENSEMBL proteins:

ENSP00000317272 ENSP00000380860

Human Recombinant Proteins

	Invitrogen human recombinant proteins for MET
	Millipore Purified and/or Recombinant MET Protein
	Sigma-Aldrich Proteins for MET
	R&D Systems Recombinant & Natural Proteins for MET (HGF R/c-MET)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Met (c-Met))
	Human Recombinant Proteins from Abnova (MET)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	IEA	--
GO:0005887	integral to plasma membrane	TAS	1846706
GO:0009925	basal plasma membrane	IDA	15314156
GO:0016020	membrane	IEA	--
GO:0019861	flagellum	IEA	--

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Antibodies for MET:

	Invitrogen Antibodies for MET
	Millipore Mono- and Polyclonal Antibodies for the study of MET
	Sigma-Aldrich Antibodies for MET
	R&D Systems Antibodies for MET (HGF R/c-MET)
	Cell Signaling Technology (CST) Antibodies for MET
	Antibodies from Abcam (Met (c-Met)), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MET)
	Novus Biologicals Antibodies for MET

Assays for MET:

	Invitrogen Assays for MET
	Millipore Kits and Assays for the Analysis of MET
	R&D Systems ELISAs for MET (HGF R/c-MET) (see all)
	Cell Signaling Technology (CST) Sandwich ELISA Kits for MET
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P08581

ProtoNet protein and cluster: P08581

2 Blocks protein families:

IPB002909 Cell surface receptor IPT/TIG

IPB008266 Tyrosine protein kinase

UniProtKB/Swiss-Prot: MET_HUMAN, P08581

Domain: The kinase domain is involved in SPSB1 binding

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family

Similarity: Contains 3 IPT/TIG domains

Similarity: Contains 1 protein kinase domain

Similarity: Contains 1 Sema domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MET)
		Millipore RNAi Products for the Analysis of MET Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (MET)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000245

Applied Biosystems Silencer® siRNAs for MET

Sigma-Aldrich siRNA and siRNA Panels for MET

Sigma-Aldrich shRNA Panels and shRNA for MET

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000245
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000245
untagged cDNA clones in CMV expression vector (see all 2): NM_000245

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001127500

UniProtKB/Swiss-Prot: MET_HUMAN, P08581

Function: Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase

activity. Functions in cell proliferation, scattering, morphogenesis and survival

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Enzyme Number (IUBMB): EC 2.7.10.1

Genatlas biochemistry entry for MET:

met proto-oncogene,transmembrane receptor (tyrosine kinase) for hepatocyte growth factor,with two

alternatively spliced isoforms,important regulator of cell proliferation and differentiation,organ

regeneration,embryogenesis and tumorogenesis,amplified in the glioblastomas,mutated in childhood

hepatocellular carcinomas and hereditary papillary renal carcinomas (role in the acceleration of

carcinogenesis),paralog to MST1R

15/17 MGI mutant phenotypes (inferred from 19 alleles) (MGI details for Met) (see all 17 ):

behavior/neurological	cellular	craniofacial	digestive/alimentary	embryogenesis
growth/size	immune system	lethality-prenatal/perinatal	life span-post-weaning/aging	limbs/digits/tail
liver/biliary system	muscle	nervous system	normal	renal/urinary system

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004872	receptor activity	IEA	--
GO:0005008	hepatocyte growth factor receptor activity	TAS	10871856
GO:0005515	protein binding	IPI	11571281
GO:0005524	ATP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for MET (Your Favorite Gene powered by Ingenuity) (see all 7 )

Macropinocytosis
HGF Signaling
Hepatic Fibrosis / Hepatic Stellate Cell Activation
FGF Signaling
Clathrin-mediated Endocytosis

GeneDecks MET for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for MET

5/150 Interacting proteins for MET (ENSP00000317272³ P08581^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 150 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CBL	P22681²	STRING (score=.991) MINT-14027 MINT-16046 MINT-6538928 MINT-6539019 MINT-6539363 MINT-6539411 MINT-6539399 MINT-6539587 MINT-6539435 MINT-6539423 MINT-6539375 MINT-6539387
HGF	P14210¹	STRING (score=.999) EBI-1039152, EBI-1039104
PTPRJ	Q12913¹	STRING (score=.967) EBI-1039152, EBI-2264500
RANBP9	Q96S59²	STRING (score=.959) MINT-18300 MINT-18299 MINT-18298
PLXNB1	O43157²	STRING (score=.95) MINT-49668 MINT-49661

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5/12 Gene Ontology (GO) biological process terms (links to tree view) (see all 12 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000187	activation of MAPK activity	IEA	--
GO:0001764	neuron migration	IEA	--
GO:0007166	cell surface receptor linked signal transduction	NAS	2819873
GO:0007275	multicellular organismal development	IEA	--
GO:0007420	brain development	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for MET available from Tocris Bioscience

Compound	Action	CAS number
PHA 665752	Potent and selective MET inhibitor	[477575-56-7]
K 252a	Protein kinase inhibitor	[99533-80-9]

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10/35 Novoseek chemical compound relationships for MET gene (see all 35 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	84.77	450	8601419 (5), 7688741 (5), 12183053 (4), 12856716 (4) (see all 99)
matrigel	63.74	5	19403030 (1), 9624561 (1), 14524531 (1), 16331263 (1)
phosphatidylinositol	54.43	27	7687741 (3), 8626770 (3), 17621632 (2), 10362361 (1) (see all 16)
wortmannin	44.38	3	10597286 (1), 11900489 (1), 11781826 (1)
ganglioside, gd1a	40.61	1	11745410 (1)
phosphotyrosine	39.71	4	18083107 (1), 8886986 (1), 18258742 (1), 12527708 (1)
phosphoinositide	31.54	12	15784547 (2), 10597286 (2), 12488439 (1), 11238734 (1) (see all 8)
crcs	29.35	4	16953230 (1), 18395971 (1)
pd 98,059	25.37	1	11781826 (1)
heparan sulfate	19.67	11	10037743 (2), 15332304 (1), 11073815 (1), 11435444 (1) (see all 5)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MET)
		Millipore RNAi Products for the Analysis of MET Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (MET)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000245

Sigma-Aldrich siRNA and siRNA Panels for MET

Sigma-Aldrich shRNA Panels and shRNA for MET

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000245 NM_001127500

REFSEQ mRNAs for MET gene (2 alternative transcripts):

NM_000245.2 NM_001127500.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000245 NM_001127500

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000245
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000245
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000245

Additional cDNA sequence:

AB209898.1 AF075090.1 AK025784.1 AK296974.1 AK298552.1 AK309532.1 BC016592.1 BC027979.1

BC127890.1 BC130420.1 BX648782.1 DQ656040.2 EU826567.1 EU826568.1 EU826569.1 EU826570.1

EU826571.1 EU826572.1 EU826573.1 EU826574.1 EU826575.1 EU826576.1 EU826577.1 EU826578.1

EU826579.1 EU826580.1 EU826581.1 J02958.1 M35074.1 X54559.1

11 DOTS entries:

DT.100751149 DT.455634 DT.75147308 DT.99972399 DT.92057037 DT.121045571 DT.100751150 DT.313460

DT.86858174 DT.100747120 DT.40111672

24/254 AceView cDNA sequences (see all 254 ):

CA446948 AI081443 AA600034 AA425497 AI695342 AW069049 NM_000245 AA405639

AK025784 AA278690 CA311250 BF002297 CA312027 BQ011810 AW134475 AI816925

BU193609 CB853731 BM767407 BX648782 BF431218 BQ775728 W24857 BM784469

highest scoring ESTs for MET:

AA193396 J02958 AA029024 AA029146 AA129547 AA136562 AA165044 AA190919 AA191433 AA278232

Unigene Cluster for MET:

Met proto-oncogene (hepatocyte growth factor receptor)

Hs.132966 [show with all ESTs]

Unigene Representative Sequence: NM_001127500

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for MET

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22a	·	22b
SP1:					-
SP2:					-																		-
SP3:

About this scheme

ECgene alternative splicing isoforms for MET

2 Ensembl transcripts including schematic representations:

ENST00000318493 ENST00000397752

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MET expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MET

¹ / ² / ³

14 probe-sets matching MET gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1812_s_at²^{, 3}	U95-A	1	1.00	1.00	0.71	0.69	HG1747-HT1764	0.20	1.00	0.72	1
1609_g_at²^{, 3}	U95-A	1	1.00	1.00	0.87	1.11	HG4272-HT4542	0.20	1.00	0.72	1
46302_at²^{, 3}	U95-B	1	1.00	1.00	0.82	1.28	AA193396	1.00	1.00	1.00	1
1608_at²^{, 3}	U95-A	1	1.00	1.00	0.29	1.17	HG4272-HT4542	0.20	1.00	0.72	1
35684_at²^{, 3}	U95-A	1	0.81	1.00	0.89	0.93	J02958	1.00	0.90	0.95	1
85873_at*²^{, 3}	U95-D	1	--	--	0.22	0.87	R94852	0.40	1.00	0.76	1
203510_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BG170541	0.80	1.00	0.91	1
211599_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U19348	0.40	0.50	0.45	1
213816_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AA005141	0.60	1.00	0.82	1
213807_x_at²^{, 3}	U133-A	1	0.73	1.00	--	--	BE870509	0.80	1.00	0.91	1
203510_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211599_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
213816_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
213807_x_at²	U133Plus2	1	0.73	1.00	--	--	--	--	--	--	--

GeneDecks MET for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CAATTAAAGT

SOURCE GeneReport for Unigene cluster: Hs.132966
Expression variation in blood from EXPOLDB for MET

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MET gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MET¹	--	met proto-oncogene (hepatocyte growth factor receptor)	90.92(n) 91.09(a)	403438 NM_001002963.1 NP_001002963.1
chimpanzee (Pan troglodytes)	MET¹	--	met proto-oncogene (hepatocyte growth factor receptor)	99.5(n) 99.78(a)	463671 XM_001138791.1 XP_001138791.1
cow (Bos taurus)	MET¹	--	met proto-oncogene (hepatocyte growth factor receptor)	90.46(n) 91.59(a)	280855 NM_001012999.2 NP_001013017.2
rat (Rattus norvegicus)	Met¹	--	met proto-oncogene	85.17(n) 88.84(a)	24553 NM_031517.1 NP_113705.1
mouse (Mus musculus)	Met^{1, 5}	6 (4.00 cM)⁵	met proto-oncogene^{1, 5}	86.58(n)¹ 89.7(a)¹	17295¹ NM_008591.1¹ NP_032617.1¹ AI838057⁵ AK145182⁵ (see all 25)

About this table Species with no ortholog for MET

ENSEMBL Gene Tree for MET

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MET gene

MST1R²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/540 NCBI SNPs in MET are shown (see all 540 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 175)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs41741^1,2	A,C,F,H,O	116225747(+)	`AAGATT/GGATTT`	1	--	ng3¹		16	EU EA WA NA	1474
	rs16945^1,2	A,C,F,H,O	116225890(+)	`TTACCT/CGGATT`	1	--	ng3¹		20	EA NA EU WA	1560
	rs41739^1,2	C,F,H,O	116224740(+)	`TAGAAA/GCAAAT`	2	--	ut3¹		10	EA NA EU WA	2226
	rs1621^1,2	A,C,F,H	116224842(+)	`TGCTTA/GCTACT`	2	--	ut3¹		7	MN EA EU WA	2250
	rs6566^1,2	A,C,F,H	116225654(+)	`TTAAAG/ATAAAG`	2	--	ut3¹		11	EU EA WA NA	980
	rs38839^1,2	A,C,F	116098755(+)	`TTTTTT/AAAAAT`	1	--	ng5¹		2	NA	182
	rs41738^1,2	C,F,H	116224442(+)	`TGAACA/GTGTAG`	2	--	ut3¹		4	EU EA WA	418
	rs184953^1,2	C,F	116099166(+)	`CCTGCC/ATCTGA`	1	--	ng5¹		1	MN	184
	rs33917957^1,2	C,F	116127498(+)	`CTTCAA/GCAAGA`	2	N/S	mis¹		5	MN CSAM EA	396
	rs35225896^1,2	F	116127322(+)	`AATATA/GCTTCA`	2	I/M	mis¹		5	MN CSAM EA	396

About this table

HapMap Linkage Disequilibrium images for MET (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 164860 disorders: 605074 114550 611015

UniProtKB/Swiss-Prot: MET_HUMAN, P08581

Activation of MET after rearrangement with the TPR gene produces an oncogenic protein

Defects in MET may be associated with gastric cancer

Defects in MET are a cause of hepatocellular carcinoma (HCC) [MIM:114550]

Defects in MET are a cause of hereditary papillary renal carcinoma (HPRC) [MIM:605074];

also known as papillary renal cell carcinoma 2 (RCCP2). HPRC is a form of inherited kidney cancer

characterized by a predisposition to develop multiple, bilateral papillary renal tumors. The

pattern of inheritance is consistent with autosomal dominant transmission with reduced penetrance

Genetic variations in MET may be associated with susceptibility to autism type 9 (AUTS9)

[MIM:611015]. Autism is a neurodevelopmental disorder characterized by disturbance in language,

perception and socialization. The disorder is classically defined by a triad of limited or absent

verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted,

stereotypical, and ritualized patterns of interests and behavior

10/96 Novoseek disease relationships for MET gene (see all 96 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	70.10	595	16162743 (6), 14613995 (5), 16212809 (5), 15492846 (5) (see all 99)
metastasis	69.12	185	14613995 (4), 12381909 (4), 19165419 (4), 15492787 (4) (see all 99)
cancer	62.91	283	19199866 (7), 9437998 (5), 15922853 (5), 11328532 (4) (see all 99)
papillary renal cancer hereditary	62.86	3	10456263 (1), 10491015 (1)
gastric carcinoma	61.44	66	10223227 (6), 18839537 (6), 8344755 (4), 11669338 (4) (see all 25)
carcinoma renal cell	59.21	66	10433944 (8), 10327054 (4), 9140397 (3), 9258068 (3) (see all 27)
thyroid papillary carcinoma	58.09	26	12472169 (4), 14508824 (2), 11369990 (2), 11106926 (2) (see all 11)
carcinoma	57.19	93	17549422 (4), 18221954 (3), 15492787 (3), 15590419 (3) (see all 60)
salivary gland cancer	57.10	6	16469527 (2), 19159612 (1), 18355439 (1), 16139245 (1)
gastric cancer	56.78	96	9413205 (5), 18024311 (4), 10971174 (4), 12381909 (3) (see all 42)

About this table

Human Gene Mutation Database: MET
Genetic Association Database: MET
Human Genome Epidemiology Navigator: MET (799 documents)
Tumor Gene Database: MET
Breast Cancer Gene Database: MET

(Possibly Related Articles in Doctor's Guide)
About This Section

New Method Could Help Surgeons Select Colorectal Cancer Patients for More Aggressive Treatment: Presented at ACS

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1015 PubMed articles for MET gene (see all 1015 ):

Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. (PubMed id 1846706)^{2, 3, 4} Bottaro D.P.... Aaronson S.A. (1991)
Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM. (PubMed id 12147692)^{1, 3, 4} Wang D.... Wu G. (2002)
Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas. (PubMed id 9140397)^{1, 3, 4} Schmidt L.... Zbar B. (1997)
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a. (PubMed id 14559966)^{1, 3, 4} Schiering N.... Cristiani C. (2003)
The semaphorin 4D receptor controls invasive growth by coupling with Met. (PubMed id 12198496)^{1, 3, 4} Giordano S.... Comoglio P.M. (2002)
Identification of the major autophosphorylation site of the Met/hepatocyte growth factor receptor tyrosine kinase. (PubMed id 1655790)^{1, 3, 4} Ferracini R.... Comoglio P.M. (1991)
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)^{3, 4} Wissing J.... Daub H. (2007)
A genetic variant that disrupts MET transcription is associated with autism. (PubMed id 17053076)^{3, 4} Campbell D.B....Levitt P. (2006)
The SH2-domian-containing inositol 5-phosphatase (SHIP)-2 binds to c- Met directly via tyrosine residue 1356 and involves hepatocyte growth factor (HGF)-induced lamellipodium formation, cell scattering and cell spreading. (PubMed id 15735664)^{3, 4} Koch A.... Tamura T. (2005)
MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met. (PubMed id 15314156)^{3, 4} Higuchi T.... Nakamura M. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 4233	HGNC: 7029	AceView: MET	Ensembl:ENSG00000105976	euGenes: HUgn4233
ECgene: MET	H-InvDB: MET

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MET	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=MET
Wikipedia	http://en.wikipedia.org/wiki/C-MET

Licensable Technologies for MET
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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for MET:

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Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MET-related products

	Millipore Custom Antibody & Bulk Services
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Antibodies & Assays for MET

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MET Gene

protein-coding GIFtS: 75

Aliases &
Descriptions
for MET

Summaries
for MET

Genomic Location
for MET

Proteins
for MET

Protein Domains/
Families
for MET

Gene Function
for MET

Pathways & Interactions
for MET

Drugs & Compounds
for MET

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for MET

Expression
for MET

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for MET

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for MET

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for MET

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MET Gene

protein-coding GIFtS: 75

Aliases & Descriptionsfor MET

Summariesfor MET

Genomic Locationfor MET

Proteinsfor MET

Protein Domains/Familiesfor MET

Gene Functionfor MET

Pathways & Interactionsfor MET

Drugs & Compoundsfor MET

Transcriptsfor MET

Expression for MET

Orthologsfor MET

Paralogsfor MET

SNPs/Variantsfor MET

Disorders & Mutationsfor MET

Medical Newsfor MET

Publicationsfor MET

Search for MET

Genome Databases showing MET

Other Databases showing MET

Specialized Databases showing MET

Licensable Technologiesfor MET

Servicesfor MET

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MET

Summaries
for MET

Genomic Location
for MET

Proteins
for MET

Protein Domains/
Families
for MET

Gene Function
for MET

Pathways & Interactions
for MET

Drugs & Compounds
for MET

Transcripts
for MET

Expression
for MET

Orthologs
for MET

Paralogs
for MET

SNPs/Variants
for MET

Disorders & Mutations
for MET

Medical News
for MET

Publications
for MET

Licensable Technologies
for MET

Services
for MET