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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MET Gene

protein-coding   GIFtS: 78
GCID: GC07P116312

met proto-oncogene (hepatocyte growth factor receptor)
 Explore 179 diseases affiliated with
MET via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MET    

Aliases
for MET gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Met Proto-Oncogene (Hepatocyte Growth Factor Receptor)1 2     SF Receptor2 3
HGFR1 2     EC 2.7.10.13 8
RCCP21 2     AUTS92 5
Proto-Oncogene C-Met2 3     C-Met1
Scatter Factor Receptor2 3     Hepatocyte Growth Factor Receptor2
Tyrosine-Protein Kinase Met2 3     Met Proto-Oncogene Tyrosine Kinase2
HGF Receptor2 3     EC 2.7.108
HGF/SF Receptor2 3     

External Ids:    HGNC: 70291   Entrez Gene: 42332   Ensembl: ENSG000001059767   OMIM: 1648605   UniProtKB: P085813   

Export aliases for MET gene to outside databases

Previous GC identifers: GC07P114790 GC07P115853 GC07P115866 GC07P115906 GC07P116099 GC07P110678


Summaries
for MET gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MET:
The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The
primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which
are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary
renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MET_HUMAN, P08581
Function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding
to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering,
morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular
domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with
the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors
by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC.
The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects.
During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and
neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ
regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells
Function: Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells

summary for MET:
MET (Mesenchymal epithelial transition factor), also known as hepatocyte growth factor receptor (HGFR) is a
proto-oncogenic receptor tyrosine kinase. The endogenous ligand for MET is hepatocyte growth factor/scatter
factor (HGF), a disulfide-linked heterodimeric molecule produced predominantly by mesenchymal cells. In the
adult, MET expression is limited to stem and progenitor cells and is necessary for wound healing and
hepatocyte regeneration. In the embryo, MET receptors are expressed on cells of epithelial origin. They are
essential for invasive growth and mediate epithelial-mesenchymal transition (EMT). Abberant activation of
the HGF/MET pathway leads to a variety of cancers. MET mutation is associated with a poor prognosis as it
can trigger tumor growth, angiogenesis and metastasis.

Gene Wiki entry for MET (C-Met)


Genomic Views
for MET gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MET gene promoter:
         NF-1   Sp1   AP-1   p53   p300   ATF-2   FOXD3   N-Myc   S8   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): MET promoter sequence
   Search SABiosciences Chromatin IP Primers for MET

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MET


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31   Ensembl cytogenetic band:  7q31.2   HGNC cytogenetic band: 7q31

MET Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MET gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P116312:  view genomic region     (about GC identifiers)

Start:
 116,312,248 bp from pter      End:
 116,438,440 bp from pter
Size:
 126,193 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 115,707,906-115,833,890     

Proteins
for MET gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MET_HUMAN, P08581 (See protein sequence)
Recommended Name: Hepatocyte growth factor receptor precursor  
Size: 1390 amino acids; 155541 Da
Subunit: Heterodimer made of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds
PLXNB1. Interacts when phosphorylated with downstream effectors including STAT3, PIK3R1, SRC, PCLG1, GRB2 and GAB1.
Interacts with SPSB1, SPSB2 and SPSB4 (By similarity). Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356,
interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1
binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this
interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell
proliferation. Interacts with GRB10
Subcellular location: Membrane; Single-pass type I membrane protein
Subcellular location: Isoform 3: Secreted
6/48 PDB 3D structures from and Proteopedia for MET (see all 48):
1FYR (3D)        1R0P (3D)        1R1W (3D)        1SHY (3D)        1SSL (3D)        1UX3 (3D)    
Secondary accessions: A1L467 B5A932 E7EQ94 O60366 Q12875 Q9UDX7 Q9UPL8
Alternative splicing: 3 isoforms:  P08581-1   P08581-2   P08581-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MET: NX_P08581

Post-translational modifications:

  • Autophosphorylated in response to ligand binding on Tyr-1234 and Tyr-1235 in the kinase domain leading to further
    • phosphorylation of Tyr-1349 and Tyr-1356 in the C-terminal multifunctional docking site1
  • Dephosphorylated by PTPRJ at Tyr-1349 and Tyr-13651
  • Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P08581

    • 4/93 DME Specific Peptides for MET (P08581) (see all 93)
     KANLSGG  DNINMAL  RDLAARN  APLEGGT 

    MET Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_000236.2  NP_001120972.1  

    ENSEMBL proteins: 
     ENSP00000400890   ENSP00000413857   ENSP00000380860   ENSP00000317272   ENSP00000398776  
     ENSP00000398140   ENSP00000410980   ENSP00000445020  
    Reactome Protein details: P08581
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant MET Protein
    R&D Systems Recombinant & Natural Proteins for MET (HGF R/c-MET)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: MET
    OriGene Protein Over-expression Lysate (see all 2): MET
    OriGene Custom Protein Services for MET 
    GenScript Custom Purified and Recombinant Proteins Services for MET
    Novus Biologicals MET Proteins
    Novus Biologicals MET Lysates
    Sino Biological Recombinant Protein for MET
    ProSpec Recombinant Protein for MET
    Uscn Proteins for MET

    Gene Ontology (GO): 5/15 cellular component terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005615extracellular space ----
    GO:0005624membrane fraction ----
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane TAS--


    MET for ontologies           About GeneDecksing



    MET Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MET
    R&D Systems Antibodies for MET (HGF R/c-MET)
    Cell Signaling Technology (CST) Antibodies for MET 
    OriGene Antibodies (see all 2): MET
    OriGene Custom Antibody Services for MET 
    GenScript Custom Superior Antibodies Services for MET
    Novus Biologicals MET Antibodies
    Abcam antibodies for MET 
    Uscn Antibodies for MET
    ThermoFisher Antibody for MET

    Assay Products for MET: 
    EMD Millipore Kits and Assays for the Analysis of MET
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for MET (HGF R/c-MET)         (see all)
    GenScript MET-Activity-based Kinase Assay for Compound Screening
    Cell Signaling Technology (CST) Sandwich ELISA Kits for MET
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MET

    Protein Domains /
    Families
    for MET gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MET for domains           About GeneDecksing

    5/15 InterPro domains/families (see all 15):
     IPR017441 Protein_kinase_ATP_BS
     IPR014756 Ig_E-set
     IPR002165 Plexin_repeat
     IPR002909 IPT_TIG_rcpt
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry P08581

    ProtoNet protein and cluster: P08581

    2 Blocks protein families:
    IPB002909 Cell surface receptor IPT/TIG
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: MET_HUMAN, P08581
    Domain: The kinase domain is involved in SPSB1 binding
    Domain: The beta-propeller Sema domain mediates binding to HGF
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family
    Similarity: Contains 3 IPT/TIG domains
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 Sema domain


    Function
    for MET gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MET_HUMAN, P08581
    Function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding
    to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering,
    morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular
    domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with
    the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors
    by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC.
    The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects.
    During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and
    neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ
    regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells
    Function: Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the
    kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the
    kinase activity

         Genatlas biochemistry entry for MET:
    met proto-oncogene,transmembrane receptor (tyrosine kinase) for hepatocyte growth factor,with two alternatively spliced
    isoforms,important regulator of cell proliferation and differentiation,organ regeneration,embryogenesis and
    tumorogenesis,amplified in the glioblastomas,mutated in childhood hepatocellular carcinomas and hereditary papillary
    renal carcinomas (role in the acceleration of carcinogenesis),paralog to MST1R

    Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

    miRNA
    Products:            		miRTarBase miRNAs that target MET:
    hsa-mir-34b (MIRT004825), hsa-mir-1 (MIRT001357), hsa-mir-34c-5p (MIRT000757), hsa-mir-340 (MIRT005458), hsa-mir-30a (MIRT005167), hsa-mir-34b (MIRT000758), hsa-mir-206 (MIRT000185), hsa-mir-562 (MIRT005024), hsa-mir-199b-3p (MIRT004514), hsa-mir-34a (MIRT000759), hsa-mir-23b (MIRT004292)

    OriGene 3'-UTR Clone (see all 2): MET
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MET
    8/50 QIAGEN miScript miRNA Assays for microRNAs that regulate MET (see all 50):
    hsa-miR-549 hsa-miR-513a-5p hsa-miR-128 hsa-miR-624* hsa-miR-301a hsa-miR-449a hsa-miR-23a hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmid: MET 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MET (see all 7)
    OriGene shRNA RFP: MET
    OriGene siRNA: MET
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MET

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MET

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MET (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MET (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): MET (NM_001127500)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MET
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MET 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MET
    Search LifeMap BioReagents cell lines for MET

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MET

    Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity TAS--
    GO:0005008hepatocyte growth factor-activated receptor activity IEA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--


    MET for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for MET:
     Decreased substrate adherent c  Decreased telomerase activity  Decreased viability after Chla  Increased mitotic index 
     Synthetic lethal/sick with VHL 

    Animal Models:
         Mouse knock-outs for MET: Mettm1Cbm Mettm1.1Sst Mettm2.1Cbm
         15/20 MGI mutant phenotypes (inferred from 21 alleles) (MGI details for Met) (see all 20):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  growth/size  homeostasis/metabolism  immune system  limbs/digits/tail 
     liver/biliary system  mortality/aging  muscle  nervous system  no phenotypic analysis 

    MET for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MET gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/47 super-pathways (see all 47) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptotic Pathways in Synovial Fibroblasts
    8/12 pathways (see all 12)
    		Apoptotic Pathways in Synovial Fibroblasts1.00
    		Cellular Apoptosis Pathway0.65
    		p53 Mediated Apoptosis0.84
    		ERK5 Signaling0.61
    		Mitochondrial Apoptosis0.73
    		eIF2 Pathway0.60
    		Telomerase Components in Cell Signaling0.72
    		Rac1 Pathway0.58
    2GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53
    		NFAT in Immune Response0.58
    		P2Y Receptor Signaling0.38
    3Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51
    4TGF-Beta Pathway
    		TGF-Beta Pathway1.00
    		JAK-STAT Pathway0.57
    		MAPK Family Pathway0.60
    		JNK Pathway0.50
    5Nanog in Mammalian ESC Pluripotency
    		Nanog in Mammalian ESC Pluripotency1.00
    		14-3-3 Induced Intracellular Signaling0.59
    		GSK3 Signaling0.61
    		eNOS Signaling0.48

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5 EMD Millipore Pathways for MET
        Development HGF signaling pathway
    Cell adhesion PLAU signaling
    Signal transduction IP3 signaling
    Signal transduction AKT signaling
    Cell adhesion Cadherin-mediated cell adhesion

    5/62 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MET (see all 62)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 Cell Signaling Technology (CST) Pathway for MET
        Tyrosine Kinases / Adaptors

    1 Tocris Bioscience Pathway for MET
        Akt Pathway

    5 GeneGo (Thomson Reuters) Pathways for MET
        Cell adhesion PLAU signaling
    Development HGF signaling pathway
    Signal transduction AKT signaling
    Signal transduction IP3 signaling
    Cell adhesion Cadherin-mediated cell adhesion

    5/12 BioSystems Pathways for MET (see all 12) 
        Focal Adhesion
    Signaling Pathways in Glioblastoma
    Alpha6-Beta4 Integrin Signaling Pathway
    Signaling events mediated by TCPTP
    Stabilization and expansion of the E-cadherin adherens junction

    5        Reactome Pathways for MET
        Developmental Biology
    Semaphorin interactions
    Sema4D in semaphorin signaling
    Sema4D mediated inhibition of cell attachment and migration
    Axon guidance


    5/11         Kegg Pathways  (Kegg details for MET) (see all 11):
        Cytokine-cytokine receptor interaction
    Endocytosis
    Axon guidance
    Focal adhesion
    Adherens junction


    MET for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MET

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/165 Interacting proteins for MET (P085811, 2, 3 ENSP000003172724) via UniProtKB, MINT, STRING, and/or I2D (see all 165)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CBLP226812, 3, ENSP000002640334MINT-14027 MINT-16046 MINT-6538928 MINT-6539019 MINT-6539363 MINT-6539411 MINT-6539399 MINT-6539587 MINT-6539435 MINT-6539423 MINT-6539375 MINT-6539387 I2D: score=4 STRING: ENSP00000264033
    RANBP9Q96S592, 3, ENSP000000116194MINT-18300 MINT-18299 MINT-18298 I2D: score=3 STRING: ENSP00000011619
    HGFP142101, 3, ENSP000002223904EBI-1039152,EBI-1039104 I2D: score=4 STRING: ENSP00000222390
    PLXNB3Q9ULL41, 3, ENSP000003553784EBI-1039152,EBI-311073 I2D: score=1 STRING: ENSP00000355378
    PTPRJQ129132, 3, ENSP000004000104MINT-7026889 MINT-7026855 MINT-7026878 MINT-7026866 I2D: score=3 STRING: ENSP00000400010
    About this table

    Gene Ontology (GO): 5/50 biological process terms (GO ID links to tree view) (see all 50):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IEA--
    GO:0001101response to acid ----
    GO:0001764neuron migration ----
    GO:0001889liver development IEA--
    GO:0001890placenta development IEA--


    MET for ontologies           About GeneDecksing



    Drugs & Compounds
    for MET gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MET for compounds           About GeneDecksing

    EMD Millipore small molecules for MET:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for MET available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CrizotinibPotent c-MET/ALK inhibitor[877399-52-5]
    PF 04217903 mesylateHighly selective c-Met inhibitor[956906-93-7]
    PHA 665752Potent and selective MET inhibitor[477575-56-7]
    K 252aProtein kinase inhibitor[99533-80-9]
    SU 11274Selective inhibitor of MET kinase activity[658084-23-2]

    2 HMDB Compounds for MET    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    9 DrugBank Compounds for MET    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    K-252a-- 97161-97-2target--17139284 17016423 10592235
    1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide-- --target--10592235
    1-[(2-NITROPHENYL)SULFONYL]-1H-PYRROLO[3,2-B]PYRIDINE-6-CARBOXAMIDE-- --target--10592235
    2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide-- --target--10592235
    3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine-- --target--10592235
    3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol-- --target--10592235
    6-{[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline-- --target--10592235
    N-(3-chlorophenyl)-N-methyl-2-oxo-3-[(3,4,5-trimethyl-1H-pyrrol-2-yl)methyl]-2H-indole-5-sulfonamide-- --target--10592235
    N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamide-- --target--10592235

    10/64 Novoseek chemical compound relationships for MET gene (see all 64)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 85.5 498 8601419 (5), 7688741 (5), 12183053 (4), 12856716 (4) (see all 99)
    matrigel 62.1 5 19403030 (1), 9624561 (1), 14524531 (1), 16331263 (1)
    vegf 57.2 89 15274358 (7), 19877526 (5), 15492846 (4), 9652757 (3) (see all 33)
    phosphatidylinositol 54.5 28 7687741 (3), 8626770 (3), 17621632 (2), 10362361 (1) (see all 17)
    gefitinib 51.9 16 19589612 (3), 19808904 (2), 19240370 (1), 17495520 (1) (see all 7)
    ly294002 49.5 4 11753639 (1), 12611639 (1)
    wortmannin 48.7 3 10597286 (1), 11900489 (1), 11781826 (1)
    ag 1478 41.9 1 10722725 (1)
    phosphotyrosine 39.9 4 18083107 (1), 8886986 (1), 18258742 (1), 12527708 (1)
    ganglioside, gd1a 38.4 1 11745410 (1)

    Search CenterWatch for drugs/clinical trials and news about MET 

    Transcripts
    for MET gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MET gene (2 alternative transcripts): 
    NM_000245.2  NM_001127500.1  

    Unigene Cluster for MET:

    Met proto-oncogene (hepatocyte growth factor receptor)
    Hs.132966  [show with all ESTs]
    Unigene Representative Sequence: NM_001127500
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000437703 ENST00000456159 ENST00000397752(uc003vij.3 uc010lkh.3 uc011knj.2)
    ENST00000318493(uc003vii.1 uc010lkg.3 uc022akk.1 uc011kmz.1 uc011kna.1 uc011knb.1 uc011knc.1 uc011knd.2 uc011knf.2 uc011kne.2 uc011kng.1 uc011knh.1 uc011kni.2)
    ENST00000495962 ENST00000422097 ENST00000454623 ENST00000436117 ENST00000539704


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): MET
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MET
    8/50 QIAGEN miScript miRNA Assays for microRNAs that regulate MET (see all 50):
    hsa-miR-549 hsa-miR-513a-5p hsa-miR-128 hsa-miR-624* hsa-miR-301a hsa-miR-449a hsa-miR-23a hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmid: MET 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MET (see all 7)
    OriGene shRNA RFP: MET
    OriGene siRNA: MET
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MET
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MET (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MET (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): MET (NM_001127500)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MET
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MET 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MET
    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MET
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MET

    Additional cDNA sequence: 

    AB209898.1 AF075090.1 AK025784.1 AK296974.1 AK298552.1 AK309532.1 BC016592.1 BC027979.1 
    BC127890.1 BC130420.1 BX648782.1 DQ656040.2 EU176015.1 EU826567.1 EU826568.1 EU826569.1 
    EU826570.1 EU826571.1 EU826572.1 EU826573.1 EU826574.1 EU826575.1 EU826576.1 EU826577.1 
    EU826578.1 EU826579.1 EU826580.1 EU826581.1 J02958.1 M35074.1 X54559.1 

    10 DOTS entries:

    DT.100751149  DT.455634  DT.75147308  DT.99972399  DT.92057037  DT.121045571  DT.100751150  DT.313460 
    DT.86858174  DT.100747120 

    24/254 AceView cDNA sequences (see all 254):

    NM_000245 BQ011810 BU172879 AA278690 AA449385 AI816925 W24857 CB121758 
    BM766323 AI679273 AI129597 AA456079 BU619853 BM784469 AW134475 BM767407 
    BM764845 BF431218 BM760175 BF002297 AW008775 BM783890 BU630712 CA446948 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MET    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b
    SP1:              -                                                                                                                                       
    SP2:              -                                                     -                                                                                 
    SP3:                                                                                                                                                      


    ECgene alternative splicing isoforms for MET

    Expression
    for MET gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MET expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAATTAAAGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MET expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/20 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 20) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Head MesenchymeHypobranchial MusclesMuscle Progenitor CellsSkeletal Muscle
    Head MesenchymeHypobranchial MusclesMyoblastsSkeletal Muscle
    LimbForelimb MyotomeLimb Muscle Progenitor CellsSkeletal Muscle
    LimbHindlimb MyotomeLimb Muscle Progenitor CellsSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMuscle Progenitor CellsSkeletal Muscle
    SomiteCervical Ventrolateral Dermomyotome LipMuscle Progenitor CellsSkeletal Muscle
    SomiteLumbar Ventrolateral Dermomyotome LipMuscle Progenitor CellsSkeletal Muscle
    AmnionAmniotic MembraneAmniotic CellsAmnion, Extraembryonic Tissues
    KidneyUreteric BudUreteric Bud Tip CellsKidney
    LimbForelimb Muscle Satellite PoolForelimb Muscle Satellite CellsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    Hepatocyte-like cells (Functional hepatocyt...)
    Posterior foregut-like cells (A scalable, suspensi...)

    See MET Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MET

    SOURCE GeneReport for Unigene cluster: Hs.132966

    UniProtKB/Swiss-Prot: MET_HUMAN, P08581
    Tissue specificity: Expressed in normal hepatocytes as well as in epithelial cells lining the stomach, the small and
    the large intestine. Found also in basal keratinocytes of esophagus and skin. High levels are found in liver,
    gastrointestinal tract, thyroid and kidney. Also present in the brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including MET (see all 9): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Lung Cancer in human mouse rat
              WNT Signaling Targets in human mouse rat
              Type I Interferon Response in human mouse rat
              Liver Cancer in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MET
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MET
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MET
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MET
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MET

    Orthologs
    for MET gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MET gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MET1 met proto-oncogene (hepatocyte growth factor receptor) 72.08(n)
    73.19(a)    		   396134  NM_205212.1  NP_990543.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MET6
    		 --
    		 69(a)
    		 1 ↔ 1
    		 5(61124988-61234182)
    African clawed frog
    (Xenopus laevis)    		 Amphibia met-A2 c-met/hepatocyte growth factor receptor 73.39(n)    AB027411.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.182902 Danio rerio D249 mRNA, partial cds 72.02(n)    AB055680.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea F11E6.83 Eukaryotic protein kinase domain 46(a)
    (best of 9)    		   IV(17444692-17450635)   --


    ENSEMBL Gene Tree for MET (if available)
    TreeFam Gene Tree for MET (if available) 

    Paralogs
    for MET gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MET gene
    AXL2  TIE12  RYK2  TEK2  TYRO32  MERTK2  MST1R2  
    18/63 SIMAP similar genes for MET using alignment to 23 protein entries:     MET_HUMAN (see all proteins) (see all similar genes):
    EPHA2    FLT4    ABL1    BTK kinase deficient isoform 6    EML4-ALK variant 6    EML4-ALK variant 7
    EML4/ALK fusion    EPHA6    KIF5B-ALK    PTK7    tec    IGF1R
    HCK    EPHA5    LTK    FES    ALK    CD74/ROS fusion

    MET for paralogs           About GeneDecksing



    Genomic Variants
    for MET gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1867 NCBI SNPs in MET are shown (see all 1867)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1219132431,2
    		Cpathogenic115812914(+) ATATCA/GTGGGA 4 H R mis10--------
    rs1219132461,2
    		Cpathogenic115818864(+) CATGTA/GTGATA 4 Y C mis10--------
    rs563910071,2
    		C,F,other115807440(+) CCCAAC/TTACAG 4 T I mis11Minor allele frequency- T:0.01EU 1323
    rs362226751,2
    		C,F,--115706992(+) ACATTC/TAAGAA 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1839024181,2
    		C--115707084(+) AAAAAA/GAAAAA 2 -- us2k10--------
    rs362226771,2
    		C,F,--115707278(+) GGGTGG/AGCGCG 2 -- us2k11Minor allele frequency- A:0.02NA 120
    rs132321541,2
    		C,F,H--115707547(+) GGGCAG/TAGGCG 2 -- us2k16Minor allele frequency- T:0.01NS NA 944
    rs715645641,2
    		C,F,--115707554(+) GGCGGG/AAGGAA 2 -- us2k13Minor allele frequency- A:0.05NA 124
    rs18588301,2
    		C,F,--115707886(+) CAGCCC/GGGCCG 2 -- us2k1 tfbs33Minor allele frequency- G:0.34NA 124
    rs751955681,2
    		F,--115708238(+) CCACGG/ACGAGG 2 -- int11Minor allele frequency- A:0.02EA 120

    HapMap Linkage Disequilibrium report for MET (116312248 - 116438440 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MET: --
    Human Gene Mutation Database (HGMD): MET

    5/10 SABiosciences Cancer Mutation PCR Assays for MET (see all 10):
    Cosmic IdAA Change
    690p.Y1248H
    705p.R988C
    691p.M1268T
    29632p.L982_D1028del
    706p.E168D
    5/9 SABiosciences Cancer Mutation PCR Arrays containing MET (see all 9):
    Cancer Comprehensive Panel 384HT
    Oncogene Panel 384HT
    Receptor Tyrosine Kinase (RTK) (Panel I)
    Tyrosine Kinases & Cell Signaling Pathways Panel 384HT
    Oncogene and Tumor Suppressor Panel 384HT
    3 SABiosciences qBiomarker Copy Number PCR Arrays containing MET:
    Oncogenes & Tumor Suppressor Genes 384HC
    Lung Cancer
    Kinases & Phosphatases
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MET
    DNA2.0 Custom Variant and Variant Library Synthesis for MET

    Disorders / Diseases
    for MET gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MET for disorders           About GeneDecksing

    OMIM gene information: 164860   
    OMIM disorders: 605074  114550  611015  
    UniProtKB/Swiss-Prot: MET_HUMAN, P08581
  • Note=Activation of MET after rearrangement with the TPR gene produces an oncogenic protein
  • Note=Defects in MET may be associated with gastric cancer
  • Defects in MET are a cause of hepatocellular carcinoma (HCC) [MIM:114550]
  • Defects in MET are a cause of renal cell carcinoma papillary (RCCP) [MIM:605074]. It is a subtype of renal
    • cell carcinoma tending to show a tubulo-papillary architecture formed by numerous, irregular, finger-like projections
    of connective tissue. Renal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from
    cells of the proximal renal tubular epithelium. It is subclassified into common renal cell carcinoma (clear cell,
    non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma
    with medullary carcinoma of the kidney, and unclassified renal cell carcinoma
  • Note=A common allele in the promoter region of the MET shows genetic association with susceptibility to autism
    • in some families. Functional assays indicate a decrease in MET promoter activity and altered binding of specific
    transcription factor complexes
  • Note=MET activating mutations may be involved in the development of a highly malignant, metastatic syndrome
    • known as cancer of unknown primary origin (CUP) or primary occult malignancy. Systemic neoplastic spread is generally
    a late event in cancer progression. However, in some instances, distant dissemination arises at a very early stage, so
    that metastases reach clinical relevance before primary lesions. Sometimes, the primary lesions cannot be identified
    in spite of the progresses in the diagnosis of malignancies

    20/179 diseases for MET (see all 179):    About MalaCards
    papillary renal carcinoma    von hippel-lindau disease    carcinoma    renal carcinoma
    tall cell variant papillary carcinoma    autism suseptibility 9    renal cell carcinoma, papillary, familial and sporadic    malignant peripheral nerve sheath tumor
    alveolar soft part sarcoma    salivary gland cancer    acral lentiginous melanoma    hepatocellular carcinoma (fibrolamellar variant)
    spinal chordoma    doxorubicin induced cardiomyopathy    proliferative diabetic retinopathy    amyotrophic lateral sclerosis (als)
    refractive error    fibrous histiocytoma    renal cell carcinoma    squamous cell carcinoma

    5 diseases from the University of Copenhagen DISEASES database for MET:
    Carcinoma     Lung cancer     Hepatocellular carcinoma     Malignant glioma
    Renal cell carcinoma

    10/96 Novoseek disease relationships for MET gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 71.6 679 16162743 (6), 14613995 (5), 16212809 (5), 15492846 (5) (see all 99)
    metastasis 69.6 209 14613995 (4), 12381909 (4), 19165419 (4), 15492787 (4) (see all 99)
    cancer 65.5 337 19199866 (7), 9437998 (5), 15922853 (5), 11328532 (4) (see all 99)
    papillary renal cancer hereditary 61.8 3 10456263 (1), 10491015 (1)
    gastric carcinoma 60.2 66 10223227 (6), 18839537 (6), 8344755 (4), 11669338 (4) (see all 25)
    thyroid papillary carcinoma 59.5 26 12472169 (4), 14508824 (2), 11369990 (2), 11106926 (2) (see all 11)
    carcinoma renal cell 57.8 66 10433944 (8), 10327054 (4), 9140397 (3), 9258068 (3) (see all 27)
    carcinoma 57.5 102 17549422 (4), 20420246 (4), 18221954 (3), 19533669 (3) (see all 64)
    hepatocellular carcinoma 56.9 67 8276372 (5), 7927256 (4), 8778194 (4), 16227408 (4) (see all 30)
    gastric cancer 56 103 9413205 (5), 20331976 (5), 18024311 (4), 10971174 (4) (see all 43)

    Genetic Association Database (GAD): MET
    Human Genome Epidemiology (HuGE) Navigator: MET (1184 documents)
    Tumor Gene Database (TGDB): MET

    Export disorders for MET gene to outside databases

    Publications
    for MET gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MET gene, integrated from 9 sources (see all 1353):
    (articles sorted by number of sources associating them with MET)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. (PubMed id 1846706)1, 2, 3 Bottaro D.P.... Aaronson S.A. (1991)
    2. Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM. (PubMed id 12147692)1, 2, 9 Wang D.... Wu G. (2002)
    3. The SH2-domian-containing inositol 5-phosphatase (SHIP)-2 binds to c- Met directly via tyrosine residue 1356 and involves hepatocyte growth factor (HGF)-induced lamellipodium formation, cell scattering and cell spreading. (PubMed id 15735664)1, 2, 9 Koch A.... Tamura T. (2005)
    4. Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas. (PubMed id 9140397)1, 2, 9 Schmidt L.... Zbar B. (1997)
    5. Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis. (PubMed id 18593464)1, 2, 9 Jin P.... Paleolog E.M. (2008)
    6. Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a. (PubMed id 14559966)1, 2, 9 Schiering N.... Cristiani C. (2003)
    7. The semaphorin 4D receptor controls invasive growth by coupling with Met. (PubMed id 12198496)1, 2, 9 Giordano S.... Comoglio P.M. (2002)
    8. Identification of the major autophosphorylation site of the Met/hepatocyte growth factor receptor tyrosine kinase. (PubMed id 1655790)1, 2, 9 Ferracini R.... Comoglio P.M. (1991)
    9. MET mutations in cancers of unknown primary origin (C UPs). (PubMed id 20949619)1, 2 Stella G.M....Comoglio P.M. (2011)
    10. Structure of the human receptor tyrosine kinase met in complex with the Listeria invasion protein InlB. (PubMed id 17662939)1, 2 Niemann H.H....Heinz D.W. (2007)

    External Searches for MET gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MET gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4233 HGNC: 7029 AceView: MET Ensembl:ENSG00000105976 euGenes: HUgn4233
    ECgene: MET Kegg: 4233 H-InvDB: MET

    Other Databases showing MET gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MET gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MET Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MET Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MET
    Wikipedia http://en.wikipedia.org/wiki/C-MET

    Intellectual Property
    for MET gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MET gene:
    Search GeneIP for patents involving MET

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for MET gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     EMD Millipore Purified and/or Recombinant MET Protein
     EMD Millipore small molecules (inhibitor) for MET
     EMD Millipore Kits and Assays for the Analysis of MET
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