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MET Gene

protein-coding   GIFtS: 78
GCID: GC07P116312

Met Proto-Oncogene
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Aliases
for MET gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Met Proto-Oncogene1 2     EC 2.7.10.13 8
Hepatocyte Growth Factor Receptor1 2     AUTS92
Proto-Oncogene C-Met2 3     HGFR2
Scatter Factor Receptor2 3     RCCP22
Tyrosine-Protein Kinase Met2 3     c-Met2
HGF Receptor2 3     Met Proto-Oncogene Tyrosine Kinase2
HGF/SF Receptor2 3     EC 2.7.108
SF Receptor2 3     

External Ids:    HGNC: 70291   Entrez Gene: 42332   Ensembl: ENSG000001059767   OMIM: 1648605   UniProtKB: P085813   

Export aliases for MET gene to outside databases

Previous GC identifers: GC07P114790 GC07P115853 GC07P115866 GC07P115906 GC07P116099 GC07P110678


Summaries
for MET gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MET Gene:
The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The
primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits,
which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with
papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Jul 2008)

GeneCards Summary for MET Gene:
MET (met proto-oncogene) is a protein-coding gene. Diseases associated with MET include papillary carcinoma, and renal cell carcinoma, papillary, 1, familial and somatic. GO annotations related to this gene include hepatocyte growth factor-activated receptor activity and protein tyrosine kinase activity. An important paralog of this gene is AXL.

UniProtKB/Swiss-Prot: MET_HUMAN, P08581
Function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by
binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation,
scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on
its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by
ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of
these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK,
PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while
PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in
gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In
adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also
differentiation and proliferation of hematopoietic cells
Function: Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells

summary for MET Gene:
MET (Mesenchymal epithelial transition factor), also known as hepatocyte growth factor receptor (HGFR) is a
proto-oncogenic receptor tyrosine kinase. The endogenous ligand for MET is hepatocyte growth factor/scatter
factor (HGF), a disulfide-linked heterodimeric molecule produced predominantly by mesenchymal cells. In the
adult, MET expression is limited to stem and progenitor cells and is necessary for wound healing and
hepatocyte regeneration. In the embryo, MET receptors are expressed on cells of epithelial origin. They are
essential for invasive growth and mediate epithelial-mesenchymal transition (EMT). Abberant activation of
the HGF/MET pathway leads to a variety of cancers. MET mutation is associated with a poor prognosis as it
can trigger tumor growth, angiogenesis and metastasis.

Gene Wiki entry for MET (C-Met) Gene


Genomic Views
for MET gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MET gene promoter:
         NF-1   Sp1   AP-1   p53   p300   ATF-2   FOXD3   N-Myc   S8   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): MET promoter sequence
   Search Chromatin IP Primers for MET

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MET


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31   Ensembl cytogenetic band:  7q31.2   HGNC cytogenetic band: 7q31

MET Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MET gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P116312:  view genomic region     (about GC identifiers)

Start:
 116,312,444 bp from pter      End:
 116,438,440 bp from pter
Size:
 125,997 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 115,707,906-115,833,890     

Proteins
for MET gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MET_HUMAN, P08581 (See protein sequence)
Recommended Name: Hepatocyte growth factor receptor precursor  
Size: 1390 amino acids; 155541 Da
Subunit: Heterodimer made of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds
PLXNB1. Interacts when phosphorylated with downstream effectors including STAT3, PIK3R1, SRC, PCLG1, GRB2 and
GAB1. Interacts with SPSB1, SPSB2 and SPSB4 (By similarity). Interacts with INPP5D/SHIP1. When phosphorylated at
Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and
SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive
effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth
factor-induced cell proliferation. Interacts with GRB10. Interacts with PTPN1 and PTPN2
Selected PDB 3D structures from and Proteopedia for MET (see all 55):
1FYR (3D)        1R0P (3D)        1R1W (3D)        1SHY (3D)        1SSL (3D)        1UX3 (3D)    
Secondary accessions: A1L467 B5A932 E7EQ94 O60366 Q12875 Q9UDX7 Q9UPL8
Alternative splicing: 3 isoforms:  P08581-1   P08581-2   P08581-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MET: NX_P08581

Explore proteomics data for MET at MOPED

Post-translational modifications: 

  • Autophosphorylated in response to ligand binding on Tyr-1234 and Tyr-1235 in the kinase domain leading to further
    phosphorylation of Tyr-1349 and Tyr-1356 in the C-terminal multifunctional docking site. Dephosphorylated by
    PTPRJ at Tyr-1349 and Tyr-1365. Dephosphorylated by PTPN1 and PTPN21
  • Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation1
  • Ubiquitination2 at Lys962
  • Glycosylation2 at Asn45, Asn106, Asn149, Asn202, Asn399, Asn405, Asn607, Asn635, Asn785, Asn879,
                                 Asn930
  • Modification sites at PhosphoSitePlus
    • Selected DME Specific Peptides for MET (P08581) (see all 93)
     KANLSGG  DNINMAL  RDLAARN  APLEGGT 


    See MET Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000236.2  NP_001120972.1  

    ENSEMBL proteins: 
     ENSP00000413857   ENSP00000380860   ENSP00000317272   ENSP00000398776   ENSP00000398140  
     ENSP00000410980   ENSP00000445020  
    Reactome Protein details: P08581

    MET Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant MET Protein
    R&D Systems Recombinant & Natural Proteins for MET (HGF R/c-MET)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MET
    OriGene Protein Over-expression Lysate for MET
    OriGene MassSpec for MET
    OriGene Custom Protein Services for MET
    GenScript Custom Purified and Recombinant Proteins Services for MET
    Novus Biologicals MET Proteins
    Novus Biologicals MET Lysates
    Sino Biological Recombinant Protein for MET
    Sino Biological Cell Lysate for MET
    ProSpec Recombinant Protein for MET
    Browse Proteins at Cloud-Clone Corp.

    MET Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MET
    R&D Systems Antibodies for MET (HGF R/c-MET)
    Cell Signaling Technology (CST) Antibodies for MET 
    OriGene Antibodies for MET
    OriGene Custom Antibody Services for MET
    Novus Biologicals MET Antibodies
    Abcam antibodies for MET
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for MET
    LSBio Antibodies in human, mouse, rat for MET

    MET Assay Products:

    EMD Millipore Kits and Assays for the Analysis of MET
    OriGene Custom Assay Services for MET
    R&D Systems ELISAs for MET (HGF R/c-MET)         (see all)
    GenScript MET-Activity-based Kinase Assay for Compound Screening
    Cell Signaling Technology (CST) Sandwich ELISA Kits for MET
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.

    Domains /
    Families
    for MET gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 IUPHAR Guide to PHARMACOLOGY protein family classification: met proto-oncogene (hepatocyte growth factor receptor)
    Met family
    HGF (hepatocyte growth factor) receptor family

    Selected InterPro protein domains (see all 14):
     IPR017441 Protein_kinase_ATP_BS
     IPR014756 Ig_E-set
     IPR002165 Plexin_repeat
     IPR002909 IPT
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry P08581

    ProtoNet protein and cluster: P08581

    2 Blocks protein domains:
    IPB002909 Cell surface receptor IPT/TIG
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: MET_HUMAN, P08581
    Domain: The kinase domain is involved in SPSB1 binding
    Domain: The beta-propeller Sema domain mediates binding to HGF
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family
    Similarity: Contains 3 IPT/TIG domains
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 Sema domain


    MET for domains           About GeneDecksing


    Function
    for MET gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MET_HUMAN, P08581
    Function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by
    binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation,
    scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on
    its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by
    ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of
    these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK,
    PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while
    PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in
    gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In
    adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also
    differentiation and proliferation of hematopoietic cells
    Function: Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the
    kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus
    increasing the kinase activity

         Genatlas biochemistry entry for MET:
    met proto-oncogene,transmembrane receptor (tyrosine kinase) for hepatocyte growth factor,with two alternatively
    spliced isoforms,important regulator of cell proliferation and differentiation,organ regeneration,embryogenesis
    and tumorogenesis,amplified in the glioblastomas,mutated in childhood hepatocellular carcinomas and hereditary
    papillary renal carcinomas (role in the acceleration of carcinogenesis),paralog to MST1R

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity TAS--
    GO:0004714transmembrane receptor protein tyrosine kinase activity ----
    GO:0004872receptor activity ----
    GO:0005008hepatocyte growth factor-activated receptor activity IEA--
         
    MET for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for MET:
     Decreased substrate adherent c  Decreased telomerase activity  Decreased viability after Chla  Increased mitotic index 
     Synthetic lethal/sick with VHL 

         Selected MGI mutant phenotypes (inferred from 21 alleles) (MGI details for Met) (see all 21):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  immune system 
     limbs/digits/tail  liver/biliary system  mortality/aging  muscle  nervous system 

    MET for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MET: Mettm1Cbm Mettm1.1Sst Mettm2.1Cbm

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MET
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MET

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MET
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MET

    miRNA
    Products:            		miRTarBase miRNAs that target MET:
    hsa-mir-133b (MIRT016691), hsa-mir-320a (MIRT044529), hsa-mir-449b-5p (MIRT006351), hsa-mir-23b-3p (MIRT004292), hsa-mir-34c-5p (MIRT000757), hsa-mir-1 (MIRT001357), hsa-mir-34b-3p (MIRT004825), hsa-mir-30a-5p (MIRT005167), hsa-mir-340-5p (MIRT005458), hsa-mir-199a-3p (MIRT001969), hsa-mir-31-5p (MIRT035528), hsa-mir-206 (MIRT000185), hsa-mir-34b-5p (MIRT000758), hsa-mir-1303 (MIRT035879), hsa-mir-562 (MIRT005024), hsa-mir-34a-5p (MIRT000759), hsa-mir-130a-3p (MIRT007137), hsa-mir-449a (MIRT006346)

    Block miRNA regulation of human, mouse, rat MET using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MET (see all 50):
    hsa-miR-549 hsa-miR-513a-5p hsa-miR-128 hsa-miR-624* hsa-miR-301a hsa-miR-449a hsa-miR-23a hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmid: MET 3' UTR sequence
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for MET
    Predesigned siRNA for gene silencing in human, mouse, rat MET

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MET

    Clone
    Products:             		 OriGene clones in human, mouse for MET (see all 13)
    OriGene ORF clones in mouse, rat for MET
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MET (NM_001127500)
    Sino Biological Human cDNA Clone for MET
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MET
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MET

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MET
    Browse ESI BIO Cell Lines and PureStem Progenitors for MET 
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MET


    Localization
    for MET gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Subcellular locations from UniProtKB/Swiss-Prot
    MET_HUMAN, P08581: Membrane; Single-pass type I membrane protein
    MET_HUMAN, P08581: Isoform 3: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    cytoskeleton2
    nucleus2
    cytosol1
    endoplasmic reticulum1
    endosome1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS1846706
    GO:0009925basal plasma membrane IDA15314156
    GO:0016020membrane ----

    MET for ontologies           About GeneDecksing


    Pathways & Interactions
    for MET gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MET About   (see all 53)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Focal adhesion
    		Focal adhesion0.65
    		HGF Pathway0.34
    		Focal Adhesion0.65
    2PEDF Induced Signaling
    		STAT3 Pathway0.47
    		Cytokine-cytokine receptor interaction0.43
    		Endothelin-1 Signaling Pathway0.46
    3Glioma
    		Melanoma0.43
    		Signaling Pathways in Glioblastoma0.36
    4Apoptotic Pathways in Synovial Fibroblasts
    		Mitochondrial Apoptosis0.85
    		PPAR Pathway0.66
    		Cellular Apoptosis Pathway0.85
    		Rac1 Pathway0.65
    		Apoptotic Pathways in Synovial Fibroblasts0.84
    		Actin-Based Motility by Rho Family GTPases0.62
    		p53 Mediated Apoptosis0.84
    		ERK5 Signaling0.61
    5GPCR Pathway
    		Ras Pathway0.73
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.73
    		NFAT in Immune Response0.58
    		GPCR Pathway0.62
    		Estrogen Pathway0.55
    		Pancreatic Adenocarcinoma0.59
    		P2Y Receptor Signaling0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for MET
        Akt Signaling Pathway

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MET (see all 62)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 Cell Signaling Technology (CST) Pathway for MET
        Tyrosine Kinases / Adaptors

    1 Tocris Bioscience Pathway for MET
        Akt Pathway

    5 GeneGo (Thomson Reuters) Pathways for MET
        Cell adhesion PLAU signaling
    Development HGF signaling pathway
    Signal transduction AKT signaling
    Signal transduction IP3 signaling
    Cell adhesion Cadherin-mediated cell adhesion

    Selected BioSystems Pathways for MET (see all 12)
        Focal Adhesion
    Signaling Pathways in Glioblastoma
    Alpha6-Beta4 Integrin Signaling Pathway
    Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
    a6b1 and a6b4 Integrin signaling


    1 Reactome Pathway for MET
        Sema4D mediated inhibition of cell attachment and migration


    Selected Kegg Pathways  (Kegg details for MET) (see all 17):
        Ras signaling pathway
    Rap1 signaling pathway
    Cytokine-cytokine receptor interaction
    Endocytosis
    PI3K-Akt signaling pathway


    MET for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MET (see all 9): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Lung Cancer in human mouse rat
              WNT Signaling Targets in human mouse rat
              Type I Interferon Response in human mouse rat
              Liver Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MET

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MET (P085811, 2, 3 ENSP000003172724) via UniProtKB, MINT, STRING, and/or I2D (see all 175)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CBLP226811, 2, 3, ENSP000002640334EBI-1039152,EBI-518228 MINT-14027 MINT-16046 MINT-6538928 MINT-6539019 MINT-6539363 MINT-6539411 MINT-6539399 MINT-6539587 MINT-6539435 MINT-6539423 MINT-6539375 MINT-6539387 I2D: score=4 STRING: ENSP00000264033
    RANBP9Q96S592, 3, ENSP000000116194MINT-18300 MINT-18299 MINT-18298 I2D: score=3 STRING: ENSP00000011619
    HGFP142101, 3, ENSP000002223904EBI-1039152,EBI-1039104 I2D: score=4 STRING: ENSP00000222390
    PLXNB3Q9ULL41, 3, ENSP000003553784EBI-1039152,EBI-311073 I2D: score=1 STRING: ENSP00000355378
    PTPRJQ129131, 2, 3, ENSP000004000104EBI-1039152,EBI-2264500 MINT-7026889 MINT-7026855 MINT-7026878 MINT-7026866 I2D: score=3 STRING: ENSP00000400010
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IEA--
    GO:0001889liver development IEA--
    GO:0001890placenta development IEA--
    GO:0006468protein phosphorylation ----
    GO:0007165signal transduction TAS1846706

    MET for ontologies           About GeneDecksing



    Drugs & Compounds
    for MET gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for MET (see all 19)     About this table
    CompoundAction CAS #
    (R)-Crizotinibselective, ATP-competitive, small molecule tyrosine kinase inhibitor of c-Met[877399-52-5]
    AMG-208highly selective Met inhibitor[1002304-34-8]
    AMG-458potent inhibitor of human and mouse Met[913376-83-7]
    BMS-777607small-molecule Met-related kinases inhibitor of Met[1025720-94-8]
    c-Met inhibitor 1inhibitor of c-Met[1357072-61-7]
    Cabozantinib (XL184, BMS-907351)Multi-target kinase inhibitor, inhibits c-Met, VEGFR2, and RET[849217-68-1]
    EMD-1214063inhibitor of MET tyrosine kinase[1100598-32-0]
    INCB28060novel, ATP-competitive inhibitor of Met[1029712-80-8]
    JNJ-38877605ATP-competitive inhibitor for the catalytic activity of Met[943540-75-8]
    LY2801653potent, orally bioavailable, small-molecule inhibitor of MET. [1206799-15-6]

    Compounds for MET available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CrizotinibPotent c-MET/ALK inhibitor[877399-52-5]
    PF 04217903 mesylateHighly selective c-Met inhibitor[956906-93-7]
    PHA 665752Potent and selective MET inhibitor[477575-56-7]
    SU 11274Selective inhibitor of MET kinase activity[658084-23-2]

    2 HMDB Compounds for MET    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    10 DrugBank Compounds for MET    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    K-252a-- 97161-97-2target--17139284 17016423 10592235
    Cabozantinibcabozantinib s-malate (see all 2)849217-68-1targetantagonist21606412 21926191
    1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide-- --target--10592235
    1-[(2-NITROPHENYL)SULFONYL]-1H-PYRROLO[3,2-B]PYRIDINE-6-CARBOXAMIDE-- --target--10592235
    2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide-- --target--10592235
    3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine-- --target--10592235
    3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol-- --target--10592235
    6-{[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline-- --target--10592235
    N-(3-chlorophenyl)-N-methyl-2-oxo-3-[(3,4,5-trimethyl-1H-pyrrol-2-yl)methyl]-2H-indole-5-sulfonamide-- --target--10592235
    N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamide-- --target--10592235

    1 IUPHAR Ligand for MET (met proto-oncogene (hepatocyte growth factor receptor))    About this table
    LigandTypeActionAffinityPubmed IDs
    hepatocyte growth factor
    		NoneNone--

    Selected Novoseek inferred chemical compound relationships for MET gene (see all 64)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 85.5 498 8601419 (5), 7688741 (5), 12183053 (4), 12856716 (4) (see all 99)
    matrigel 62.1 5 19403030 (1), 9624561 (1), 14524531 (1), 16331263 (1)
    vegf 57.2 89 15274358 (7), 19877526 (5), 15492846 (4), 9652757 (3) (see all 33)
    phosphatidylinositol 54.5 28 7687741 (3), 8626770 (3), 17621632 (2), 10362361 (1) (see all 17)
    gefitinib 51.9 16 19589612 (3), 19808904 (2), 19240370 (1), 17495520 (1) (see all 7)
    ly294002 49.5 4 11753639 (1), 12611639 (1)
    wortmannin 48.7 3 10597286 (1), 11900489 (1), 11781826 (1)
    ag 1478 41.9 1 10722725 (1)
    phosphotyrosine 39.9 4 18083107 (1), 8886986 (1), 18258742 (1), 12527708 (1)
    ganglioside, gd1a 38.4 1 11745410 (1)



    MET for compounds           About GeneDecksing



    Transcripts
    for MET gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for MET gene (2 alternative transcripts): 
    NM_000245.2  NM_001127500.1  

    Unigene Cluster for MET:

    Met proto-oncogene (hepatocyte growth factor receptor)
    Hs.132966  [show with all ESTs]
    Unigene Representative Sequence: NM_001127500
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000456159 ENST00000397752(uc003vij.3 uc010lkh.3 uc011knj.2)
    ENST00000318493(uc003vii.1 uc010lkg.3 uc022akk.1 uc011kmz.1 uc011kna.1 uc011knb.1 uc011knc.1 uc011knd.2 uc011knf.2 uc011kne.2 uc011kng.1 uc011knh.1 uc011kni.2)
    ENST00000495962 ENST00000422097 ENST00000454623 ENST00000436117 ENST00000539704

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:             		 Block miRNA regulation of human, mouse, rat MET using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MET (see all 50):
    hsa-miR-549 hsa-miR-513a-5p hsa-miR-128 hsa-miR-624* hsa-miR-301a hsa-miR-449a hsa-miR-23a hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmid: MET 3' UTR sequence
    Inhib. RNA
    Products:             		OriGene RNAi products in human, mouse, rat for MET
    Predesigned siRNA for gene silencing in human, mouse, rat MET
    Clone
    Products:             		 OriGene clones in human, mouse for MET (see all 13)
    OriGene ORF clones in mouse, rat for MET
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MET (NM_001127500)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MET
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MET
    Primer
    Products:            		OriGene qSTAR qPCR primer pairs in human, mouse for MET
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MET
      QuantiTect SYBR Green Assays in human, mouse, rat MET
      QuantiFast Probe-based Assays in human, mouse, rat MET

    Additional mRNA sequence: 

    AB209898.1 AF075090.1 AK025784.1 AK296974.1 AK298552.1 AK309532.1 BC016592.1 BC027979.1 
    BC127890.1 BC130420.1 BX648782.1 DQ656040.2 EU176015.1 EU826567.1 EU826568.1 EU826569.1 
    EU826570.1 EU826571.1 EU826572.1 EU826573.1 EU826574.1 EU826575.1 EU826576.1 EU826577.1 
    EU826578.1 EU826579.1 EU826580.1 EU826581.1 J02958.1 M35074.1 X54559.1 

    10 DOTS entries:

    DT.100751149  DT.455634  DT.75147308  DT.99972399  DT.92057037  DT.121045571  DT.100751150  DT.313460 
    DT.86858174  DT.100747120 

    Selected AceView cDNA sequences (see all 254):

    BM783890 BU619853 AI679273 BF002297 BF431218 CB853731 BU630712 AW134475 
    CB270398 AW008775 CA312027 AA456079 AA449385 BI495988 NM_000245 BQ012025 
    AA405639 BQ775728 BU172879 W24857 AW009019 CB121758 AA278690 AA826121 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MET    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b
    SP1:              -                                                                                                                                       
    SP2:              -                                                     -                                                                                 
    SP3:                                                                                                                                                      


    ECgene alternative splicing isoforms for MET

    Expression
    for MET gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MET expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAATTAAAGT
    MET Expression
    About this image


    MET expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 14 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Conventional Dendritic Cells I Spleen
             Peripheral blood-derived hematopoietic stem cells
     
     Head Mesenchyme (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Hypobranchial Muscles
     
     Somite (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Cervical Ventrolateral Dermomyotome Lip
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Limb Muscle Progenitor Cells Forelimb Myotome
    MET Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    MET Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.132966

    UniProtKB/Swiss-Prot: MET_HUMAN, P08581
    Tissue specificity: Expressed in normal hepatocytes as well as in epithelial cells lining the stomach, the small
    and the large intestine. Found also in basal keratinocytes of esophagus and skin. High levels are found in liver,
    gastrointestinal tract, thyroid and kidney. Also present in the brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MET (see all 9): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Lung Cancer in human mouse rat
              WNT Signaling Targets in human mouse rat
              Type I Interferon Response in human mouse rat
              Liver Cancer in human mouse rat

    Primer
    Products:    		OriGene qSTAR qPCR primer pairs in human, mouse for MET
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MET
    QuantiTect SYBR Green Assays in human, mouse, rat MET
    QuantiFast Probe-based Assays in human, mouse, rat MET
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MET

    Orthologs
    for MET gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for MET gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Met1 , 5 met proto-oncogene1, 5 86.44(n)1
    89.63(a)1    		   6 (7.83 cM)5
    172951  NM_008591.21  NP_032617.21 
     174638005 
    chicken
    (Gallus gallus)    		 Aves MET1 met proto-oncogene (hepatocyte growth factor receptor) 72.08(n)
    73.19(a)    		   396134  NM_205212.1  NP_990543.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MET6
    		 met proto-oncogene
    		 70(a)
    		 1 ↔ 1
    		 5(61092084-61236231)
    African clawed frog
    (Xenopus laevis)    		 Amphibia met-A2 c-met/hepatocyte growth factor receptor 73.39(n)    AB027411.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.182902 Danio rerio D249 mRNA, partial cds 72.02(n)    AB055680.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea F11E6.83 Eukaryotic protein kinase domain 46(a)
    (best of 9)    		   IV(17444692-17450635)   --


    ENSEMBL Gene Tree for MET (if available)
    TreeFam Gene Tree for MET (if available)

    Paralogs
    for MET gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for MET gene
    AXL2  RYK2  TYRO32  MERTK2  MST1R2  
    Selected SIMAP similar genes for MET using alignment to 22 protein entries:     MET_HUMAN (see all proteins) (see all similar genes):
    EPHA2    FLT4    ABL1    BTK kinase deficient isoform 6    EML4-ALK variant 6    EML4-ALK variant 7
    EML4/ALK fusion    EPHA6    KIF5B-ALK    PTK7    tec    IGF1R
    HCK    EPHA5    LTK    FES    ALK    CD74/ROS fusion

    MET for paralogs           About GeneDecksing



    Genomic Variants
    for MET gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for MET (see all 2360)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    VAR_0324884
    		Renal cell carcinoma papillary (RCCP)4--see VAR_0324882 H Y mis40--------
    VAR_0324814
    		Gastric cancer4--see VAR_0324812 P L mis40--------
    VAR_0324934
    		Hepatocellular carcinoma (HCC)4--see VAR_0324932 M I mis40--------
    VAR_0324894
    		Renal cell carcinoma papillary (RCCP)4--see VAR_0324892 H D mis40--------
    VAR_0324854
    		Renal cell carcinoma papillary (RCCP)4--see VAR_0324852 V I mis40--------
    VAR_0062934
    		Renal cell carcinoma papillary (RCCP)4--see VAR_0062932 Y H mis40--------
    VAR_0062944
    		Renal cell carcinoma papillary (RCCP)4--see VAR_0062942 M T mis40--------
    VAR_0062874
    		Renal cell carcinoma papillary (RCCP)4--see VAR_0062872 V L mis40--------
    VAR_0062864
    		Renal cell carcinoma papillary (RCCP)4--see VAR_0062862 M T mis40--------
    VAR_0324924
    		Hepatocellular carcinoma (HCC)4--see VAR_0324922 K R mis40--------

    HapMap Linkage Disequilibrium report for MET (116312444 - 116438440 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for MET:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1092803CNV Insertion17803354
    nsv366908CNV Insertion16902084
    nsv831107CNV Gain17160897
    esv274927CNV Gain+Loss21479260
    nsv7405OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): MET
    Selected Site Specific Mutation Identification with PCR Assays for MET (see all 10):
    Cosmic IdAA Change
    690p.Y1248H
    705p.R988C
    691p.M1268T
    29632p.L982_D1028del
    706p.E168D
    Selected Site Specific Cancer Mutation PCR Panels containing MET (see all 9):
    Cancer Comprehensive Panel 384HT
    Oncogene Panel 384HT
    Receptor Tyrosine Kinase (RTK) (Panel I)
    Tyrosine Kinases & Cell Signaling Pathways Panel 384HT
    Oncogene and Tumor Suppressor Panel 384HT
    3 Copy Number PCR Panels containing MET:
    Oncogenes & Tumor Suppressor Genes 384HC
    Lung Cancer
    Kinases & Phosphatases
    SeqTarget long-range PCR primers for resequencing MET
    DNA2.0 Custom Variant and Variant Library Synthesis for MET

    Disorders / Diseases
    for MET gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 164860   
    OMIM disorders: 605074  114550  
    UniProtKB/Swiss-Prot: MET_HUMAN, P08581
  • Note=Activation of MET after rearrangement with the TPR gene produces an oncogenic protein
  • Note=Defects in MET may be associated with gastric cancer
  • Hepatocellular carcinoma (HCC) [MIM:114550]: A primary malignant neoplasm of epithelial liver cells. The
    major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV)
    infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes. Note=The
    disease is caused by mutations affecting the gene represented in this entry
  • Renal cell carcinoma papillary (RCCP) [MIM:605074]: A subtype of renal cell carcinoma tending to show a
    tubulo-papillary architecture formed by numerous, irregular, finger-like projections of connective tissue. Renal
    cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal
    renal tubular epithelium. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Note=A common allele in the promoter region of the MET shows genetic association with susceptibility to
    autism in some families. Functional assays indicate a decrease in MET promoter activity and altered binding of
    specific transcription factor complexes
  • Note=MET activating mutations may be involved in the development of a highly malignant, metastatic
    syndrome known as cancer of unknown primary origin (CUP) or primary occult malignancy. Systemic neoplastic spread
    is generally a late event in cancer progression. However, in some instances, distant dissemination arises at a
    very early stage, so that metastases reach clinical relevance before primary lesions. Sometimes, the primary
    lesions cannot be identified in spite of the progresses in the diagnosis of malignancies

    • Selected diseases for MET (see all 158):    
    About MalaCards
    papillary carcinoma    renal cell carcinoma, papillary, 1, familial and somatic    papillary renal carcinoma    hepatocellular carcinoma, childhood
    salivary gland cancer    spinal chordoma    tall cell variant papillary carcinoma    hepatocellular carcinoma, childhood-onset
    papillary renal cell carcinoma    ovarian clear cell adenocarcinoma    acral lentiginous melanoma    breast carcinoma in situ
    hepatocellular carcinoma    renal cell carcinoma    inflammatory breast carcinoma    large cell medulloblastoma
    clear cell adenocarcinoma    doxorubicin induced cardiomyopathy    gastric cardia adenocarcinoma    malignant mesothelioma

    5 diseases from the University of Copenhagen DISEASES database for MET:
    Carcinoma     Lung cancer     Hepatocellular carcinoma     Malignant glioma
    Renal cell carcinoma

    MET for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for MET gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 71.6 679 16162743 (6), 14613995 (5), 16212809 (5), 15492846 (5) (see all 99)
    metastasis 69.6 209 14613995 (4), 12381909 (4), 19165419 (4), 15492787 (4) (see all 99)
    cancer 65.5 337 19199866 (7), 9437998 (5), 15922853 (5), 11328532 (4) (see all 99)
    papillary renal cancer hereditary 61.8 3 10456263 (1), 10491015 (1)
    gastric carcinoma 60.2 66 10223227 (6), 18839537 (6), 8344755 (4), 11669338 (4) (see all 25)
    thyroid papillary carcinoma 59.5 26 12472169 (4), 14508824 (2), 11369990 (2), 11106926 (2) (see all 11)
    carcinoma renal cell 57.8 66 10433944 (8), 10327054 (4), 9140397 (3), 9258068 (3) (see all 27)
    carcinoma 57.5 102 17549422 (4), 20420246 (4), 18221954 (3), 19533669 (3) (see all 64)
    hepatocellular carcinoma 56.9 67 8276372 (5), 7927256 (4), 8778194 (4), 16227408 (4) (see all 30)
    gastric cancer 56 103 9413205 (5), 20331976 (5), 18024311 (4), 10971174 (4) (see all 43)

    Genetic Association Database (GAD): MET
    Human Genome Epidemiology (HuGE) Navigator: MET (1184 documents)
    Tumor Gene Database (TGDB): MET

    Export disorders for MET gene to outside databases

    Publications
    for MET gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for MET gene, integrated from 10 sources (see all 1448):
    (articles sorted by number of sources associating them with MET)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A genetic variant that disrupts MET transcription is associated with autism. (PubMed id 17053076)1, 2, 4 Campbell D.B....Levitt P. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    2. Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. (PubMed id 1846706)1, 2, 3 Bottaro D.P.... Aaronson S.A. (Science 1991)
    3. Ethnic differences and functional analysis of MET mutations in lung cancer. (PubMed id 19723643)1, 4, 9 Krishnaswamy S....Salgia R. (Clin. Cancer Res. 2009)
    4. Met gene copy number predicts the prognosis for completely resected non-small cell lung cancer. (PubMed id 19037978)1, 4, 9 Okuda K....Fujii Y. (Cancer Sci. 2008)
    5. Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM. (PubMed id 12147692)1, 2, 9 Wang D.... Wu G. (J. Biol. Chem. 2002)
    6. The SH2-domian-containing inositol 5-phosphatase (SHIP)-2 binds to c- Met directly via tyrosine residue 1356 and involves hepatocyte growth factor (HGF)-induced lamellipodium formation, cell scattering and cell spreading. (PubMed id 15735664)1, 2, 9 Koch A.... Tamura T. (Oncogene 2005)
    7. Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas. (PubMed id 9140397)1, 2, 9 Schmidt L.... Zbar B. (Nat. Genet. 1997)
    8. Association of genetic variation in the MET proto-oncogene with schizophrenia and general cognitive ability. (PubMed id 20080979)1, 4, 9 Burdick K.E....Malhotra A.K. (Am J Psychiatry 2010)
    9. Hepatocyte growth factor and myopia: genetic association analyses in a Caucasian population. (PubMed id 19471602)1, 4, 9 Yanovitch T....Young T.L. (Mol. Vis. 2009)
    10. Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis. (PubMed id 18593464)1, 2, 9 Jin P.... Paleolog E.M. (Arthritis Res. Ther. 2008)

    External Searches for MET gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MET gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 4233 HGNC: 7029 AceView: MET Ensembl:ENSG00000105976 euGenes: HUgn4233
    ECgene: MET Kegg: 4233 H-InvDB: MET

    Other Databases showing MET gene

    (According to HUGE)
    About This Section

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    Specialized Databases showing MET gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MET Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MET Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=MET[genesymbol]
    Wikipedia http://en.wikipedia.org/wiki/C-MET

    Intellectual Property
    for MET gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for MET gene:
    Search GeneIP for patents involving MET

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    Products
    for MET gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus
     EMD Millipore Kits and Assays for the Analysis of MET
     EMD Millipore Purified and/or Recombinant MET Protein
     EMD Millipore Mono- and Polyclonal Antibodies for the study of MET
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for MET (HGF R/c-MET)   Browse Cell Culture Products  
     ELISAs for MET (HGF R/c-MET)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for MET (HGF R/c-MET)   Browse Stem Cell Products  
     cDNA Clones for MET (HGF R/c-MET)   Proteome Profiler Antibody Arrays for MET (HGF R/c-MET)  
     OriGene Antibodies for MET   OriGene RNAi products in human, mouse, rat for MET  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for MET  
     OriGene MassSpec something-or-other for MET   OriGene clones in human, mouse for MET  
     OriGene qSTAR qPCR primer pairs in human, mouse for MET   OriGene Purified Protein for MET  
     OriGene ORF clones in mouse, rat for MET   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MET   OriGene Custom Protein Services for MET  

         		 
     Block miRNA regulation of human, mouse, rat MET using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MET
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MET Predesigned siRNA for gene silencing in human, mouse, rat MET
     QuantiFast Probe-based Assays in human, mouse, rat MET QuantiTect SYBR Green Assays in human, mouse, rat MET
     PCR Arrays including human, mouse, rat MET Search Chromatin IP Primers for MET
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MET  GeneGlobe Interaction Network for MET
     Regulatory tfbs in MET promoter
     GenScript Custom Purified and Recombinant Proteins Services for MET GenScript cDNA clones with any tag delivered in your preferred vector for MET
     GenScript MET-Activity-based Kinase Assay for Compound Screening GenScript Custom overexpressing Cell Line Services for MET
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for MET 

     Tocris compounds for MET
     Proteins for MET
     Cell Lysates for MET
     cDNA Clones for MET
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MET antibodies
     MET proteins
     MET lysates
     Antibodies for MET
     See all of Abcam's Antibodies, Kits and Proteins for MET
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for MET
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for MET
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MET
     SwitchGear 3'UTR luciferase reporter plasmids for MET
     SwitchGear Promoter luciferase reporter plasmids for MET
     ThermoFisher Antibody for MET
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MET
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MET
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MET
     LSBio Antibodies in human, mouse, rat for MET
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     ApexBio compounds for MET
           
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