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Aliases for MESTIT1 Gene

Subcategory (RNA class) for MESTIT1 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for MESTIT1 Gene

  • MEST Intronic Transcript 1, Antisense RNA 2 3 5
  • MEST Intronic Transcript 1, Antisense RNA (Non-Protein Coding) 2
  • MEST Intronic Transcript 1 (Non-Protein Coding) 3
  • Paternally Expressed Gene, Antisense Transcript 3
  • MEST Antisense RNA 1 (Non-Protein Coding) 2
  • Non-Protein Coding RNA 40 2
  • NCRNA00040 3
  • MEST-AS1 3
  • MEST-IT1 3
  • MEST-IT 3
  • PEG1-AS 3

External Ids for MESTIT1 Gene

Previous GeneCards Identifiers for MESTIT1 Gene

  • GC07U900012
  • GC07M130126
  • GC07M124489

Summaries for MESTIT1 Gene

Entrez Gene Summary for MESTIT1 Gene

  • This gene encodes a non-protein coding antisense RNA that is imprinted, and preferentially expressed from the paternal allele. It is located in an intron of MEST gene in the opposite orientation, and shares the promoter region in common with one of the promoters (P2) of MEST gene. The antisense RNA is expressed predominantly in testis and mature motile spermatozoa, suggesting that it may be involved in the regulation of MEST expression during development.[provided by RefSeq, Oct 2010]

GeneCards Summary for MESTIT1 Gene

MESTIT1 (MEST Intronic Transcript 1, Antisense RNA) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with MESTIT1 include Silver-Russell Syndrome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MESTIT1 Gene

Genomics for MESTIT1 Gene

Regulatory Elements for MESTIT1 Gene

Enhancers for MESTIT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F130488 0.5 ENCODE 0.8 -0.5 -548 7.5 HDGF ARNT ZNF766 GATA2 NCOA1 CREB3 MEF2D MBD2 SMARCA4 MYNN COPG2 CPA5 GC07P130498 MESTIT1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MESTIT1 on UCSC Golden Path with GeneCards custom track

Promoters for MESTIT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000069136 -1928 5400 HDGF ATF1 PKNOX1 ARNT ZNF766 GATA2 NCOA1 CREB3 MEF2D MBD2

Genomic Location for MESTIT1 Gene

Chromosome:
7
Start:
130,486,042 bp from pter
End:
130,491,172 bp from pter
Size:
5,131 bases
Orientation:
Minus strand

Genomic View for MESTIT1 Gene

Genes around MESTIT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MESTIT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MESTIT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MESTIT1 Gene

Proteins for MESTIT1 Gene

Post-translational modifications for MESTIT1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MESTIT1 Gene

Domains & Families for MESTIT1 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MESTIT1 Gene

Function for MESTIT1 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MESTIT1 Gene

Localization for MESTIT1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MESTIT1 Gene

Pathways & Interactions for MESTIT1 Gene

SuperPathways for MESTIT1 Gene

No Data Available

Interacting Proteins for MESTIT1 Gene

Gene Ontology (GO) - Biological Process for MESTIT1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MESTIT1 Gene

Transcripts for MESTIT1 Gene

mRNA/cDNA for MESTIT1 Gene

(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MESTIT1 Gene

MEST intronic transcript 1, antisense RNA:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MESTIT1 Gene

No ASD Table

Relevant External Links for MESTIT1 Gene

GeneLoc Exon Structure for
MESTIT1
ECgene alternative splicing isoforms for
MESTIT1

Expression for MESTIT1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MESTIT1 Gene:

MESTIT1

SOURCE GeneReport for Unigene cluster for MESTIT1 Gene:

Hs.627349
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MESTIT1 Gene

Orthologs for MESTIT1 Gene

Evolution for MESTIT1 Gene

ENSEMBL:
Gene Tree for MESTIT1 (if available)
TreeFam:
Gene Tree for MESTIT1 (if available)

No data available for Orthologs for MESTIT1 Gene

Paralogs for MESTIT1 Gene

No data available for Paralogs for MESTIT1 Gene

Variants for MESTIT1 Gene

Sequence variations from dbSNP and Humsavar for MESTIT1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10228972 -- 130,486,822(+) GCCAG(C/G)CTTGG intron-variant, downstream-variant-500B
rs10229325 -- 130,486,939(+) AGGGC(A/G)GAGAG intron-variant, downstream-variant-500B
rs10232290 -- 130,487,019(+) GAGCA(A/G)TCGAG intron-variant, downstream-variant-500B
rs10232945 -- 130,487,677(+) AGTCT(C/T)GCTCT intron-variant, nc-transcript-variant
rs111495123 -- 130,492,888(+) GTGCG(A/G)TGTAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MESTIT1 Gene

Variant ID Type Subtype PubMed ID
esv3572140 CNV loss 25503493
nsv474824 CNV novel sequence insertion 20440878
nsv476708 CNV novel sequence insertion 20440878
nsv481112 CNV novel sequence insertion 20440878
nsv481143 CNV novel sequence insertion 20440878
nsv831130 CNV loss 17160897
nsv831131 CNV loss 17160897

Relevant External Links for MESTIT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MESTIT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MESTIT1 Gene

Disorders for MESTIT1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MESTIT1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
silver-russell syndrome
  • srs
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MESTIT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MESTIT1
genes like me logo Genes that share disorders with MESTIT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MESTIT1 Gene

Publications for MESTIT1 Gene

  1. Identification and characterization of an imprinted antisense RNA (MESTIT1) in the human MEST locus on chromosome 7q32. (PMID: 12095916) Nakabayashi K. … Scherer S.W. (Hum. Mol. Genet. 2002) 2 3 64
  2. Imprinting analysis of 10 genes and/or transcripts in a 1.5-Mb MEST- flanking region at human chromosome 7q32. (PMID: 14962666) Yamada T. … Kishino T. (Genomics 2004) 3 64
  3. The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver- Russell syndrome. (PMID: 12676894) Bentley L. … Moore G.E. (J. Med. Genet. 2003) 22 64
  4. Searching for genomic variants in the MESTIT1 transcript in Silver-Russell syndrome patients. (PMID: 12746419) Meyer E. … Eggermann T. (J. Med. Genet. 2003) 3 64
  5. An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa. (PMID: 11821432) Li T. … Hoffman A.R. (J. Biol. Chem. 2002) 3 64

Products for MESTIT1 Gene

Sources for MESTIT1 Gene

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