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MEST Gene(Protein Coding)

Mesoderm Specific Transcript

GCID:
GC07P130486
GIFtS:
54
Genes Participants
UDN Logo

Aliases for MEST Gene

Aliases for MEST Gene

  • Mesoderm Specific Transcript 2 3 5
  • Paternally-Expressed Gene 1 Protein 3 4
  • PEG1 3 4
  • Mesoderm Specific Transcript (Mouse) Homolog 2
  • Mesoderm Specific Transcript Homolog (Mouse) 2
  • Mesoderm-Specific Transcript Homolog Protein 3
  • Paternally-Expressed Gene 1 2
  • EC 3.-.-.- 4

External Ids for MEST Gene

Previous GeneCards Identifiers for MEST Gene

  • GC07P128602
  • GC07P129665
  • GC07P129679
  • GC07P129719
  • GC07P129913
  • GC07P130126
  • GC07P124488

Summaries for MEST Gene

Entrez Gene Summary for MEST Gene

  • This gene encodes a member of the alpha/beta hydrolase superfamily. It is imprinted, exhibiting preferential expression from the paternal allele in fetal tissues, and isoform-specific imprinting in lymphocytes. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may play a role in development. Alternatively spliced transcript variants encoding multiple isoforms have been identified for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3 and 4, and the long arm of chromosomes 6 and 15. [provided by RefSeq, Dec 2011]

GeneCards Summary for MEST Gene

MEST (Mesoderm Specific Transcript) is a Protein Coding gene. Diseases associated with MEST include Silver-Russell Syndrome and Retinitis Pigmentosa 4, Autosomal Dominant Or Recessive. GO annotations related to this gene include hydrolase activity.

Gene Wiki entry for MEST Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEST Gene

Genomics for MEST Gene

Products:

  1. Regulatory Element

Regulatory Elements for MEST Gene

Enhancers for MEST Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G130362 2.3 VISTA FANTOM5 Ensembl ENCODE dbSUPER 31.6 -117.1 -117091 12.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 SLC30A9 ZNF143 ZNF263 MCM3 NFYC CPA5 CPA1 CPA2 MEST KLHDC10 CDC26P1 CEP41 CPA4 TMEM209 LOC105375504
GH07G130354 1.5 Ensembl ENCODE dbSUPER 29.7 -128.6 -128611 5.7 PKNOX1 ZNF133 SIN3A FEZF1 GLI4 ZNF2 ZNF121 FOS YY2 TSHZ1 CPA5 MEST CPA1 KLHDC10 CPA4 CPA2 COPG2 LOC101928632 LOC105375504
GH07G130428 1.7 Ensembl ENCODE dbSUPER 19.4 -54.7 -54688 5.1 CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF548 SP3 NFYC TBX21 MEF2D MEST CPA1 CPA4 CPA5 CPA2 LOC105375505 GC07M130398
GH07G130349 1.4 Ensembl ENCODE dbSUPER 19.3 -134.2 -134191 4.5 HDGF PKNOX1 ZFP64 YY1 FOS ZNF263 MCM3 JUNB TBX21 NFIL3 CPA5 MEST CPA1 CPA4 CPA2 COPG2 LOC101928632
GH07G130271 1.4 Ensembl ENCODE dbSUPER 15.2 -209.2 -209205 10.8 CBX3 PKNOX1 ATF1 ZBTB40 RAD21 ZNF121 HSF1 SCRT2 RCOR1 FOS MEST CPA5 CPA1 MIR335 KLHDC10 GC07M130268 CPA4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MEST on UCSC Golden Path with GeneCards custom track

Promoters for MEST Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000218009 229 801 ZFP64 ARID4B SIN3A DMAP1 ZNF48 YY1 SLC30A9 ZNF143 DEK ZHX2

Transcription factor binding sites by QIAGEN in the MEST gene promoter:

Genomic Location for MEST Gene

Chromosome:
7
Start:
130,486,171 bp from pter
End:
130,506,297 bp from pter
Size:
20,127 bases
Orientation:
Plus strand

Genomic View for MEST Gene

Genes around MEST on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEST Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEST Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MEST Gene

Proteins for MEST Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MEST Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5EB52-MEST_HUMAN
    Recommended name:
    Mesoderm-specific transcript homolog protein
    Protein Accession:
    Q5EB52
    Secondary Accessions:
    • B2R6S1
    • O14973
    • O15007
    • Q6AI49
    • Q92571

    Protein attributes for MEST Gene

    Size:
    335 amino acids
    Molecular mass:
    38830 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MEST Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEST Gene

Protein Expression for MEST Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MEST Gene

  • Glycosylation at Asn163
  • Modification sites at PhosphoSitePlus

Other Protein References for MEST Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MEST Gene

Domains & Families for MEST Gene

Protein Domains for MEST Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MEST Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5EB52

UniProtKB/Swiss-Prot:

MEST_HUMAN :
  • Belongs to the AB hydrolase superfamily.
Family:
  • Belongs to the AB hydrolase superfamily.
genes like me logo Genes that share domains with MEST: view

No data available for Gene Families for MEST Gene

Function for MEST Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for MEST Gene

GENATLAS Biochemistry:
mesoderm-specific transcript,expressed in fetal tissues from the paternal chromosome and in hydatidiform mole of androgenic origin,identical to the murine imprinted gene Peg1,unlikely to be a contributor to Silver-Russell syndrome with aberrant imprinting in invasive breast carcinomas

Enzyme Numbers (IUBMB) for MEST Gene

Gene Ontology (GO) - Molecular Function for MEST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with MEST: view
genes like me logo Genes that share phenotypes with MEST: view

Animal Models for MEST Gene

MGI Knock Outs for MEST:

Animal Model Products

CRISPR Products

miRNA for MEST Gene

miRTarBase miRNAs that target MEST

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MEST Gene

Localization for MEST Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEST Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEST gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
golgi apparatus 4
cytosol 2
peroxisome 1
nucleus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MEST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum ISS --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with MEST: view

Pathways & Interactions for MEST Gene

SuperPathways for MEST Gene

PathCards logo More details on SuperPathways for MEST
No Data Available

Interacting Proteins for MEST Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000223215%0d%0a9606.ENSP00000373637%0d%0a9606.ENSP00000359233%0d%0a9606.ENSP00000331201%0d%0a
Selected Interacting proteins: Q5EB52-MEST_HUMAN ENSP00000223215 for MEST Gene via MINT STRING IID

Gene Ontology (GO) - Biological Process for MEST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007498 mesoderm development TAS 9158153
genes like me logo Genes that share ontologies with MEST: view

No data available for Pathways by source and SIGNOR curated interactions for MEST Gene

Drugs & Compounds for MEST Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MEST Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MEST Gene

(8) REFSEQ mRNAs :
(15) Additional mRNA sequences :
(552) Selected AceView cDNA sequences:
(18) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MEST Gene

Mesoderm specific transcript:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEST Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - - - - - -
SP6: - -
SP7: - - - - - - - -
SP8: - - - -
SP9: - - - - - - - - - - - -
SP10: - -
SP11: - - - - - - -
SP12: -
SP13: -
SP14:
SP15: - - - - - - -
SP16: - -

ExUns: 14b ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c · 18d
SP1: - -
SP2: - -
SP3: - -
SP4: - - - -
SP5:
SP6: - - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for MEST Gene

GeneLoc Exon Structure for
MEST
ECgene alternative splicing isoforms for
MEST

Expression for MEST Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MEST Gene

mRNA expression in normal human tissues for MEST Gene
mRNA expression by BioGPS for MEST GenemRNA expression by GTEx for MEST Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEST Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x8.9), Adipose - Subcutaneous (x6.0), and Adrenal Gland (x4.0).

Protein differential expression in normal tissues from HIPED for MEST Gene

This gene is overexpressed in Placenta (28.3) and Adipocyte (19.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MEST Gene



NURSA nuclear receptor signaling pathways regulating expression of MEST Gene:

MEST

SOURCE GeneReport for Unigene cluster for MEST Gene:

Hs.270978

mRNA Expression by UniProt/SwissProt for MEST Gene:

Q5EB52-MEST_HUMAN
Tissue specificity: Highly expressed in hydatidiform moles, but barely expressed in dermoid cysts. Biallelic expression is detected in blood lymphocytes. Seems to imprinted in an isoform-specific manner rather than in a tissue-specific manner in lymphocytes. Isoform 1 is expressed only from the paternal allele. Isoform 2 is expressed from both the paternal allele and the maternal allele.

Evidence on tissue expression from TISSUES for MEST Gene

  • Muscle(4.4)
  • Intestine(4.3)
  • Nervous system(4)
  • Heart(3.1)
  • Lung(2.5)
genes like me logo Genes that share expression patterns with MEST: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MEST Gene

Orthologs for MEST Gene

This gene was present in the common ancestor of chordates.

Orthologs for MEST Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia MEST 34 35
  • 99.9 (n)
dog
(Canis familiaris)
 Mammalia MEST 34 35
  • 93.03 (n)
cow
(Bos Taurus)
 Mammalia MEST 34 35
  • 91.94 (n)
rat
(Rattus norvegicus)
 Mammalia Mest 34
  • 91.74 (n)
mouse
(Mus musculus)
 Mammalia Mest 34 16 35
  • 90.85 (n)
oppossum
(Monodelphis domestica)
 Mammalia MEST 35
  • 85 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia MEST 35
  • 78 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves MEST 34 35
  • 72.53 (n)
lizard
(Anolis carolinensis)
 Reptilia MEST 35
  • 75 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia mest 34
  • 69.34 (n)
zebrafish
(Danio rerio)
 Actinopterygii mest 34 35
  • 68.31 (n)
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.11262 34
Species where no ortholog for MEST was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MEST Gene

ENSEMBL:
Gene Tree for MEST (if available)
TreeFam:
Gene Tree for MEST (if available)

Paralogs for MEST Gene

Pseudogenes.org Pseudogenes for MEST Gene

genes like me logo Genes that share paralogs with MEST: view

No data available for Paralogs for MEST Gene

Variants for MEST Gene

Sequence variations from dbSNP and Humsavar for MEST Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs863223353 Likely pathogenic 130,499,898(+) ACCGT(C/T)CACTC reference, missense
rs1000112642 -- 130,499,205(+) TTCTG(A/G)GTAGC intron-variant
rs1000379468 -- 130,488,957(+) CATGT(A/G)CTCCT intron-variant, nc-transcript-variant
rs1000711380 -- 130,501,180(+) AGCAA(C/T)GGGGA intron-variant
rs1000811781 -- 130,493,595(+) CAGGA(A/G)TGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MEST Gene

Variant ID Type Subtype PubMed ID
esv3572140 CNV loss 25503493
nsv472521 CNV novel sequence insertion 20440878
nsv472979 CNV novel sequence insertion 20440878
nsv474824 CNV novel sequence insertion 20440878
nsv475312 CNV novel sequence insertion 20440878
nsv476708 CNV novel sequence insertion 20440878
nsv477727 CNV novel sequence insertion 20440878
nsv478321 CNV novel sequence insertion 20440878
nsv479379 CNV novel sequence insertion 20440878
nsv481112 CNV novel sequence insertion 20440878
nsv481143 CNV novel sequence insertion 20440878
nsv481360 CNV novel sequence insertion 20440878
nsv481618 CNV novel sequence insertion 20440878
nsv831130 CNV loss 17160897
nsv831131 CNV loss 17160897
nsv966888 CNV duplication 23825009

Variation tolerance for MEST Gene

Residual Variation Intolerance Score: 41.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MEST Gene

Human Gene Mutation Database (HGMD)
MEST
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEST

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEST Gene

Disorders for MEST Gene

MalaCards: The human disease database

(4) MalaCards diseases for MEST Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
silver-russell syndrome
  • srs
retinitis pigmentosa 4, autosomal dominant or recessive
  • retinitis pigmentosa 4
diabetes mellitus, transient neonatal, 1
  • diabetes mellitus, transient neonatal
arts syndrome
  • arts
- elite association - COSMIC cancer census association via MalaCards
Search MEST in MalaCards View complete list of genes associated with diseases

Relevant External Links for MEST

Genetic Association Database (GAD)
MEST
Human Genome Epidemiology (HuGE) Navigator
MEST
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MEST
genes like me logo Genes that share disorders with MEST: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MEST Gene

Publications for MEST Gene

  1. Genomic imprinting and chromosomal localization of the human MEST gene. (PMID: 8884280) Nishita Y. … Takagi N. (Genomics 1996) 2 3 4 22 64
  2. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 46 64
  3. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty S.E. … . (PLoS Genet. 2010) 3 46 64
  4. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M. … Lan Q. (Environ. Mol. Mutagen. 2009) 3 46 64
  5. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PMID: 19625176) Hosgood H.D. … Lan Q. (Respir Med 2009) 3 46 64

Products for MEST Gene

Sources for MEST Gene

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