Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MEST Gene

protein-coding GIFtS: 54
GCID: GC07P130126

Mesoderm Specific Transcript

(Previous names: mesoderm specific transcript (mouse) homolog, mesoderm specific...)

11 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Mesoderm Specific Transcript¹ ²		Mesoderm Specific Transcript Homolog (Mouse)¹
PEG1² ³ ⁵		Mesoderm-Specific Transcript Homolog Protein²
Paternally-Expressed Gene 1 Protein² ³		EC 3.-.-.-³
Mesoderm Specific Transcript (Mouse) Homolog¹

External Ids:	HGNC: 7028¹	Entrez Gene: 4232²	Ensembl: ENSG00000106484⁷	OMIM: 601029⁵	UniProtKB: Q5EB52³

Export aliases for MEST gene to outside databases

Previous GC identifers: GC07P128602 GC07P129665 GC07P129679 GC07P129719 GC07P129913 GC07P124488

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MEST Gene:

This gene encodes a member of the alpha/beta hydrolase superfamily. It is imprinted, exhibiting preferential expression

from the paternal allele in fetal tissues, and isoform-specific imprinting in lymphocytes. The loss of imprinting of

this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may

play a role in development. Alternatively spliced transcript variants encoding multiple isoforms have been identified

for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3 and 4, and the long arm of

chromosomes 6 and 15. (provided by RefSeq, Dec 2011)

GeneCards Summary for MEST Gene:

MEST (mesoderm specific transcript) is a protein-coding gene. Diseases associated with MEST include cystic nephroma, and silver-russell syndrome. GO annotations related to this gene include hydrolase activity.

Gene Wiki entry for MEST Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NT_007933.15 NC_018918.2 NT_079596.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MEST gene promoter:
NF-AT4 LyF-1 NF-AT NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): MEST promoter sequence

Search SABiosciences Chromatin IP Primers for MEST

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEST

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32 Ensembl cytogenetic band: 7q32.2 HGNC cytogenetic band: 7q32

MEST Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEST gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P130126: view genomic region (about GC identifiers)

Start:	130,126,046 bp from pter	End:	130,146,133 bp from pter
Size:	20,088 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 129,511,449-129,531,539

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MEST_HUMAN, Q5EB52 (See protein sequence)

Recommended Name: Mesoderm-specific transcript homolog protein

Size: 335 amino acids; 38830 Da

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)

Developmental stage: Monoallelic expression of paternally derived allele was observed in all fetal tissues examined,

including brain, skeletal muscle, kidney, adrenal, tongue, heart, skin and placenta. In 75-day fetus, expressed in the

amnion, brain, heart, lung, stomach, gut, adrenal, kidney, muscle and liver

Secondary accessions: B2R6S1 O14973 O15007 Q6AI49 Q92571

Alternative splicing: 3 isoforms: Q5EB52-1 Q5EB52-2 Q5EB52-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MEST: NX_Q5EB52

Explore proteomics data for MEST at MOPED

MEST Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (6 alternative transcripts):

NP_001240829.1 NP_001240830.1 NP_001240831.1 NP_002393.2 NP_803490.1 NP_803491.1

ENSEMBL proteins:

ENSP00000342749 ENSP00000409505 ENSP00000408933 ENSP00000367839 ENSP00000390589

ENSP00000409768 ENSP00000407222 ENSP00000223215 ENSP00000401657 ENSP00000393709

ENSP00000396504 ENSP00000473492 ENSP00000376884

Human Recombinant Protein Products for MEST:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for MEST OriGene Protein Over-expression Lysate for MEST OriGene MassSpec for MEST OriGene Custom Protein Services for MEST
	GenScript Custom Purified and Recombinant Proteins Services for MEST
	Novus Biologicals MEST Protein Novus Biologicals MEST Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for MEST

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	ISS	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

MEST for ontologies About GeneDecksing

MEST Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for MEST
	GenScript Custom Superior Antibodies Services for MEST
	Novus Biologicals MEST Antibodies
	Abcam antibodies for MEST
	Cloud-Clone Corp. Antibodies for MEST
	Search ThermoFisher Antibodies for MEST
	LSBio Antibodies in human, mouse, rat for MEST

Assay Products for MEST:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for MEST
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MEST
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for MEST Cloud-Clone Corp. CLIAs for MEST

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

1 InterPro protein domain:

IPR000639 Epox_hydrolase-like

Graphical View of Domain Structure for InterPro Entry Q5EB52

ProtoNet protein and cluster: Q5EB52

UniProtKB/Swiss-Prot: MEST_HUMAN, Q5EB52

Similarity: Belongs to the AB hydrolase superfamily

MEST for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

Genatlas biochemistry entry for MEST:

mesoderm-specific transcript,expressed in fetal tissues from the paternal chromosome and in hydatidiform mole of

androgenic origin,identical to the murine imprinted gene Peg1,unlikely to be a contributor to Silver-Russell syndrome

with aberrant imprinting in invasive breast carcinomas

Enzyme Number (IUBMB): EC 3.-.-.-¹

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003824	catalytic activity	--	--
GO:0016787	hydrolase activity	IEA	--

MEST for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for MEST:

Increased S DNA content

Upregulation of Wnt/beta-caten

8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mest):

behavior/neurological	cardiovascular system	cellular	embryogenesis	growth/size
mortality/aging	muscle	skeleton

MEST for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for MEST

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MEST

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MEST
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate MEST (see all 26):
		hsa-miR-579 hsa-miR-4291 hsa-miR-330-5p hsa-miR-181c hsa-miR-429 hsa-miR-202 hsa-miR-29a hsa-miR-29c

		SwitchGear 3'UTR luciferase reporter plasmid: MEST 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for MEST
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEST
		Sirion Biotech Custom design and validation of potent shRNA sequences against MEST

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for MEST
			Sirion Biotech Customized adenovirus for overexpression of MEST Customized adenovirus for potent knockdown of MEST

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for MEST (see all 16) OriGene ORF clones in mouse, rat for MEST OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): MEST (NM_177524)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEST
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEST

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MEST
		Search LifeMap BioReagents cell lines for MEST
		Sirion Biotech Customized stable knockdown cell line services for MEST Customized inducible knockdown cell line services for MEST Customized stable overexpressing cell line services for MEST Customized inducible overexpressing cell line services for MEST

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEST

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MEST

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/25 Interacting proteins for MEST (Q5EB52^{2, 3} ENSP00000223215⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 25)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CRELD2	Q6UXH1²^,³	MINT-8263038 MINT-8262994 I2D: score=2
FST	P19883²^,³, ENSP00000256759⁴	MINT-8263071 I2D: score=2 STRING: ENSP00000256759
BLOC1S2	Q6QNY1²^,³	MINT-8263005 I2D: score=2
CEP70	Q8NHQ1²^,³	MINT-8263016 I2D: score=2
DBN1	Q16643²^,³	MINT-8263049 I2D: score=2

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007498	mesoderm development	TAS	9158153
GO:0010883	regulation of lipid storage	IEA	--
GO:0032526	response to retinoic acid	IEA	--

MEST for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MEST

Search CenterWatch for drugs/clinical trials and news about MEST

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MEST gene (6 alternative transcripts):

NM_001253900.1 NM_001253901.1 NM_001253902.1 NM_002402.3 NM_177524.2 NM_177525.2

Unigene Cluster for MEST:

Mesoderm specific transcript

Hs.270978 [show with all ESTs]

Unigene Representative Sequence: AK055108

18 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000341441(uc003vqc.3 uc003vqd.3 uc022alp.1) ENST00000427521

ENST00000416162 ENST00000378576 ENST00000399874 ENST00000433159 ENST00000421001

ENST00000223215(uc011kph.2 uc003vqg.3) ENST00000437945 ENST00000460590

ENST00000437637 ENST00000458161 ENST00000462132 ENST00000475188 ENST00000494868

ENST00000463263 ENST00000488093 ENST00000393187(uc003vqf.3)

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MEST
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate MEST (see all 26):
		hsa-miR-579 hsa-miR-4291 hsa-miR-330-5p hsa-miR-181c hsa-miR-429 hsa-miR-202 hsa-miR-29a hsa-miR-29c

		SwitchGear 3'UTR luciferase reporter plasmid: MEST 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for MEST
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEST
		Sirion Biotech Custom design and validation of potent shRNA sequences against MEST

Clone Products:		OriGene clones in human, mouse for MEST (see all 16) OriGene ORF clones in mouse, rat for MEST OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): MEST (NM_177524)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEST
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEST

Primer Products:		OriGene qPCR primer pairs and template standards for MEST OriGene qSTAR qPCR primer pairs in human, mouse for MEST
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MEST
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEST
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEST

Additional mRNA sequence:

AK055108.1 AK098397.1 AK298984.1 AK312688.1 BC002413.2 BC011908.2 BC014564.2 BC018695.2

BC090049.1 BT007056.1 CR457040.1 CR627364.1 D78611.1 D87367.1 Y11534.1

24/30 DOTS entries (see all 30):

DT.95328531 DT.95328621 DT.100758595 DT.95094686 DT.119948 DT.100884721 DT.100884725 DT.100884705

DT.121100666 DT.121100573 DT.97773999 DT.100709054 DT.100884731 DT.97764066 DT.100884709 DT.95269672

DT.100884697 DT.40296209 DT.75118988 DT.100757054 DT.100835318 DT.100884707 DT.121100556 DT.121100562

24/552 AceView cDNA sequences (see all 552):

AA991769 AA902345 BX355637 AI185808 N90108 BM475319 AI362317 BM841421

F08689 W74431 CB163993 CN482805 AI221257 CR611176 BM666258 BM675303

AI160305 AA305289 AI280837 AI150777 BF589080 W92519 BQ229495 AW069853

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for MEST (see all 16) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7a	·	7b	^	8a	·	8b	·	8c	^	9a	·	9b	^	10a	·	10b	^	11	^	12a	·	12b	·	12c	^	13	^	14a	·
SP1:							-		-		-		-		-		-		-		-						-						-										-				-
SP2:									-		-		-		-		-		-		-						-						-										-				-
SP3:																	-		-		-						-						-										-				-
SP4:							-		-		-		-		-		-		-		-						-						-										-				-
SP5:							-		-		-		-		-		-		-		-		-				-						-										-				-

ExUns:	14b	^	15a	·	15b	·	15c	^	16a	·	16b	^	17	^	18a	·	18b	·	18c	·	18d
SP1:							-		-
SP2:							-		-
SP3:							-		-
SP4:			-		-		-		-
SP5:

ECgene alternative splicing isoforms for MEST

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MEST expression in normal human tissues (normalized intensities) MEST embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CTGAATGTAC

About this image

MEST expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/11 selected tissues (see all 11) fully expand


Brain (Nervous System) fully expand to see all 4 entries
Endothelial Cells Blood Brain Barrier
N2/LSB/S/F8-induced cells (Generation of midbrain dopaminergic, forebrain and hypothalamic...
future brain

Reproductive System (Reproductive System) fully expand to see all 2 entries
Testicular Interstitial Cells Testis Interstitium

Neural Ectoderm (Nervous System) fully expand to see all 2 entries
Floor plate-like cells (Generation of functional floor plate or neuroectoderm cells...

Ovary (Reproductive System) fully expand to see all 2 entries
Pre-Granulosa Cells Primordial Follicle

Pancreas (Endocrine System) fully expand to see all 2 entries
Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud

See MEST Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MEST

SOURCE GeneReport for Unigene cluster: Hs.270978

UniProtKB/Swiss-Prot: MEST_HUMAN, Q5EB52

Tissue specificity: Highly expressed in hydatidiform moles, but barely expressed in dermoid cysts. Biallelic expression

is detected in blood lymphocytes. Seems to imprinted in an isoform-specific manner rather than in a tissue-specific

manner in lymphocytes. Isoform 1 is expressed only from the paternal allele. Isoform 2 is expressed from both the

paternal allele and the maternal allele

SABiosciences Custom PCR Arrays for MEST

Primer Products:		OriGene qPCR primer pairs and template standards for MEST OriGene qSTAR qPCR primer pairs in human, mouse for MEST
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MEST
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEST
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEST

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEST

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MEST gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mest^{1 , 5}	mesoderm specific transcript^{1, 5}	90.85(n)¹ 97.91(a)¹		6 (12.53 cM)⁵ 17294¹ NM_008590.2¹ NP_032616.1¹ 30723547⁵
chicken (Gallus gallus)	Aves	MEST¹	mesoderm specific transcript homolog (mouse)	72.6(n) 77.61(a)		427684 XM_425258.3 XP_425258.3
lizard (Anolis carolinensis)	Reptilia	MEST⁶	Uncharacterized protein	74(a)	1 ↔ 1	GL343819.1(4513-15112)
zebrafish (Danio rerio)	Actinopterygii	mest²	mesoderm specific transcript	75.53(n)		30242 BC059471.1

ENSEMBL Gene Tree for MEST (if available)
TreeFam Gene Tree for MEST (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MEST gene

MEST for paralogs About GeneDecksing

4 Pseudogenes.org Pseudogenes for MEST
PGOHUM00000246809 PGOHUM00000237974 PGOHUM00000245487 PGOHUM00000243359

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs34288832^1,2	C	--	124507703(+)	`AAGAC-/TTTTTT`	6	--	ut3¹		2		NA CSA	4
rs61354155^1,2	C	--	130146327(+)	`AAAAG-/AAAAAA`	6	--	ds500¹		1		NA	2
rs189516089^1,2		--	133467869(+)	`GTAATA/GTATCA`	2	--	us2k¹		0	--	--	--	--
rs147362174^1,2		--	133467905(+)	`ATTCAC/TATAAT`	2	--	us2k¹		0	--	--	--	--
rs78407992^1,2	C,F	--	133467921(+)	`CAGATT/GACATG`	2	--	us2k¹		2		CSA WA	120
rs180759881^1,2		--	133468191(+)	`CCACAA/GTTTAC`	3	--	us2k¹		0	--	--	--	--
rs78916826^1,2	C,F	--	133468436(+)	`ATACCA/GGCTAT`	3	--	us2k¹		2		CSA WA	120
rs116979214^1,2	F	--	133468452(+)	`AGGCTG/AAAGCA`	3	--	us2k¹		1		NA	120
rs139089472^1,2		--	133468592(+)	`GGACAC/TAGAAA`	3	--	us2k¹		0	--	--	--	--
rs1421141^1,2	C,F,A	--	133468756(+)	`CATGGA/GAGGCT`	3	--	us2k¹		11		MN NA WA CSA EA	556

HapMap Linkage Disequilibrium report for MEST (130126046 - 130146133 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for MEST: About this table

Variant ID	Type	Subtype	PubMed ID
nsv831131	CNV	Loss	17160897
nsv831130	CNV	Loss	17160897

Human Gene Mutation Database (HGMD): MEST

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MEST

DNA2.0 Custom Variant and Variant Library Synthesis for MEST

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MEST for disorders           About GeneDecksing

OMIM gene information: 601029    OMIM disorders: --

11 diseases for MEST:    About MalaCards

cystic nephroma silver-russell syndrome angiomyolipoma beckwith-wiedemann syndrome

lung adenocarcinoma leiomyoma tuberculosis lung cancer

adenocarcinoma ovarian cancer breast cancer

1 Novoseek inferred disease relationship for MEST gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
growth retardation	58.8	1	9771709 (1)

Genetic Association Database (GAD): MEST
Human Genome Epidemiology (HuGE) Navigator: MEST (5 documents)

Export disorders for MEST gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MEST gene, integrated from 9 sources (see all 62):
(articles sorted by number of sources associating them with MEST)

Utopia: connect your pdf to the dynamic
world of online information

Genomic imprinting and chromosomal localization of the human MEST gene. (PubMed id 8884280)^{1, 2, 3, 9} Nishita Y.... Takagi N. (1996)
Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)^{1, 4} Guey L.T....Malats N. (2010)
Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)^{1, 4} Johnatty S.E.... . (2010)
PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)^{1, 4} Hosgood H.D....Lan Q. (2009)
Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)^{1, 4} Shen M....Lan Q. (2009)
Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)^{1, 4} Hosgood H.D....Lan Q. (2008)
Isoform-specific imprinting of the human PEG1/MEST gene. (PubMed id 10631159)^{1, 2} Kosaki K.... Matsuo N. (2000)
Monoallelic expression of human PEG1/MEST is paralleled by parent- specific methylation in fetuses. (PubMed id 9192843)^{1, 2} Riesewijk A.M.... Kalscheuer V.M. (1997)
Human PEG1/MEST, an imprinted gene on chromosome 7. (PubMed id 9158153)^{1, 2} Kobayashi S.... Ishino F. (1997)
PEG1 expression in maternal uniparental disomy 7. (PubMed id 9526615)^{1, 9} Cuisset L....Jeanpierre M. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4232	HGNC: 7028	AceView: MEST	Ensembl:ENSG00000106484	euGenes: HUgn4232
ECgene: MEST	H-InvDB: MEST

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MEST	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MEST	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for MEST gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MEST gene:
Search GeneIP for patents involving MEST

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Browse Recombinant/Natural Proteins
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for MEST
	OriGene qPCR primer pairs and template standards for MEST		OriGene Protein Over-expression Lysate for MEST
	OriGene MassSpec something-or-other for MEST		OriGene clones in human, mouse for MEST
	OriGene qSTAR qPCR primer pairs in human, mouse for MEST		OriGene Purified Protein for MEST
	OriGene ORF clones in mouse, rat for MEST		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for MEST		OriGene Custom Protein Services for MEST

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MEST
	Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MEST
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEST
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEST
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEST
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEST

	GenScript Custom Purified and Recombinant Proteins Services for MEST		GenScript cDNA clones with any tag delivered in your preferred vector for MEST
	GenScript Custom Assay Services for MEST		GenScript Custom Superior Antibodies Services for MEST
	GenScript Custom overexpressing Cell Line Services for MEST		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in MEST promoter
	Search Chromatin IP Primers for MEST
	RT² qPCR Primer Assay in human, mouse, rat MEST
	Search GNC Networks for MEST
	SABiosciences Custom PCR Arrays for MEST

Search Tocris compounds for MEST

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	MEST antibodies
	MEST proteins
	MEST lysates

	Antibodies for MEST
	See all of Abcam's Antibodies, Kits and Proteins for MEST
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for MEST
	Antibodies for MEST
	ELISAs for MEST
	CLIAs for MEST

Search LifeMap BioReagents cell lines for MEST

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEST

	SwitchGear 3'UTR luciferase reporter plasmids for MEST
	SwitchGear Promoter luciferase reporter plasmids for MEST

Search ThermoFisher Antibodies for MEST

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEST

	inGenious Targeting Laboratory - Custom generated mouse model solutions for MEST
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MEST

Customized:

	stable knockdown cell line services for MEST
	inducible knockdown cell line services for MEST
	design and validation of potent shRNA sequences against MEST
	adenovirus for potent knockdown of MEST
	stable overexpressing cell line services for MEST
	inducible overexpressing cell line services for MEST
	adenovirus for overexpression of MEST

LSBio Antibodies in human, mouse, rat for MEST

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes MEST gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

MEST Gene

Mesoderm Specific Transcript

Aliases
for MEST gene

Summaries
for MEST gene

Genomic Views
for MEST gene

Proteins
for MEST gene

Protein Domains /
Families
for MEST gene

Function
for MEST gene

Pathways & Interactions
for MEST gene

Drugs & Compounds
for MEST gene

Transcripts
for MEST gene

Expression
for MEST gene

Orthologs
for MEST gene

Paralogs
for MEST gene

Genomic Variants
for MEST gene

Disorders / Diseases
for MEST gene

Publications
for MEST gene

External Searches for MEST gene

Genome Databases showing MEST gene

Other Databases showing MEST gene

Specialized Databases showing MEST gene

Intellectual Property
for MEST gene

Products
for MEST gene

View Random Gene

Advanced Search

Export list of displayed genes

MEST Gene

Mesoderm Specific Transcript

Aliasesfor MEST gene

Summariesfor MEST gene

Genomic Viewsfor MEST gene

Proteinsfor MEST gene

Protein Domains /Familiesfor MEST gene

Functionfor MEST gene

Pathways & Interactionsfor MEST gene

Drugs & Compoundsfor MEST gene

Transcriptsfor MEST gene

Expression for MEST gene

Orthologsfor MEST gene

Paralogsfor MEST gene

Genomic Variantsfor MEST gene

Disorders / Diseasesfor MEST gene

Publicationsfor MEST gene

External Searches for MEST gene

Genome Databases showing MEST gene

Other Databases showing MEST gene

Specialized Databases showing MEST gene

Intellectual Propertyfor MEST gene

Productsfor MEST gene

View Random Gene

Aliases
for MEST gene

Summaries
for MEST gene

Genomic Views
for MEST gene

Proteins
for MEST gene

Protein Domains /
Families
for MEST gene

Function
for MEST gene

Pathways & Interactions
for MEST gene

Drugs & Compounds
for MEST gene

Transcripts
for MEST gene

Expression
for MEST gene

Orthologs
for MEST gene

Paralogs
for MEST gene

Genomic Variants
for MEST gene

Disorders / Diseases
for MEST gene

Publications
for MEST gene

Intellectual Property
for MEST gene

Products
for MEST gene