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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MEST Gene

protein-coding GIFtS: 55
GCID: GC07P130126

mesoderm specific transcript

(Previous names: mesoderm specific transcript (mouse) homolog, mesoderm...)

Explore 16 diseases affiliated with
MEST via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Mesoderm Specific Transcript¹ ²		Mesoderm Specific Transcript Homolog (Mouse)¹
PEG1¹ ² ³ ⁵		Mesoderm Specific Transcript Homolog²
Paternally-Expressed Gene 1 Protein² ³		Mesoderm-Specific Transcript Homolog Protein²
Mesoderm Specific Transcript (Mouse) Homolog¹		EC 3.-.-.-³

External Ids:	HGNC: 7028¹	Entrez Gene: 4232²	Ensembl: ENSG00000106484⁷	OMIM: 601029⁵	UniProtKB: Q5EB52³

Export aliases for MEST gene to outside databases

Previous GC identifers: GC07P128602 GC07P129665 GC07P129679 GC07P129719 GC07P129913 GC07P124488

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MEST:

This gene encodes a member of the alpha/beta hydrolase superfamily. It is imprinted, exhibiting preferential expression

from the paternal allele in fetal tissues, and isoform-specific imprinting in lymphocytes. The loss of imprinting of

this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may

play a role in development. Alternatively spliced transcript variants encoding multiple isoforms have been identified

for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3 and 4, and the long arm of

chromosomes 6 and 15. (provided by RefSeq, Dec 2011)

Gene Wiki entry for MEST

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MEST gene promoter:
NF-AT4 LyF-1 NF-AT NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): MEST promoter sequence

Search SABiosciences Chromatin IP Primers for MEST

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEST

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32 Ensembl cytogenetic band: 7q32.2 HGNC cytogenetic band: 7q32

MEST Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEST gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P130126: view genomic region (about GC identifiers)

Start:	130,126,046 bp from pter	End:	130,146,133 bp from pter
Size:	20,088 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 129,511,449-129,531,539

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MEST_HUMAN, Q5EB52 (See protein sequence)

Recommended Name: Mesoderm-specific transcript homolog protein

Size: 335 amino acids; 38830 Da

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)

Developmental stage: Monoallelic expression of paternally derived allele was observed in all fetal tissues examined,

including brain, skeletal muscle, kidney, adrenal, tongue, heart, skin and placenta. In 75-day fetus, expressed in the

amnion, brain, heart, lung, stomach, gut, adrenal, kidney, muscle and liver

Secondary accessions: B2R6S1 O14973 O15007 Q6AI49 Q92571

Alternative splicing: 3 isoforms: Q5EB52-1 Q5EB52-2 Q5EB52-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MEST: NX_Q5EB52

MEST Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (6 alternative transcripts):

NP_001240829.1 NP_001240830.1 NP_001240831.1 NP_002393.2 NP_803490.1 NP_803491.1

ENSEMBL proteins:

ENSP00000342749 ENSP00000409505 ENSP00000408933 ENSP00000367839 ENSP00000390589

ENSP00000409768 ENSP00000407222 ENSP00000223215 ENSP00000401657 ENSP00000393709

ENSP00000396504 ENSP00000376884

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: MEST OriGene Protein Over-expression Lysate (see all 3): MEST OriGene Custom Protein Services for MEST
	GenScript Custom Purified and Recombinant Proteins Services for MEST
	Novus Biologicals MEST Protein Novus Biologicals MEST Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MEST

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	ISS	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

MEST for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for MEST

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MEST for domains About GeneDecksing

1 InterPro domain/family:

IPR000639 Epox_hydrolase-like

Graphical View of Domain Structure for InterPro Entry Q5EB52

ProtoNet protein and cluster: Q5EB52

UniProtKB/Swiss-Prot: MEST_HUMAN, Q5EB52

Similarity: Belongs to the AB hydrolase superfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

Genatlas biochemistry entry for MEST:

mesoderm-specific transcript,expressed in fetal tissues from the paternal chromosome and in hydatidiform mole of

androgenic origin,identical to the murine imprinted gene Peg1,unlikely to be a contributor to Silver-Russell syndrome

with aberrant imprinting in invasive breast carcinomas

Enzyme Number (IUBMB): EC 3.-.-.-¹

miRNA Products:		OriGene 3'-UTR Clone (see all 3): MEST Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MEST
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate MEST (see all 26):
		hsa-miR-579 hsa-miR-4291 hsa-miR-330-5p hsa-miR-181c hsa-miR-429 hsa-miR-202 hsa-miR-29a hsa-miR-29c

		SwitchGear 3'UTR luciferase reporter plasmid: MEST 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MEST (see all 6) OriGene shRNA RFP: MEST OriGene siRNA: MEST
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEST

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MEST

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector (see all 3): MEST (NM_177524)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEST
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEST

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MEST
		Search LifeMap BioReagents cell lines for MEST

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEST

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003824	catalytic activity	--	--
GO:0016787	hydrolase activity	IEA	--

MEST for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for MEST:

Increased S DNA content

Upregulation of Wnt/beta-caten

Animal Models:
8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mest):

behavior/neurological	cardiovascular system	cellular	embryogenesis	growth/size
mortality/aging	muscle	skeleton

MEST for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MEST

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/19 Interacting proteins for MEST (Q5EB52^{2, 3} ENSP00000223215⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 19)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CRELD2	Q6UXH1²^,³	MINT-8263038 MINT-8262994 I2D: score=2
FST	P19883²^,³, ENSP00000256759⁴	MINT-8263071 I2D: score=2 STRING: ENSP00000256759
BLOC1S2	Q6QNY1²^,³	MINT-8263005 I2D: score=2
CEP70	Q8NHQ1²^,³	MINT-8263016 I2D: score=2
DBN1	Q16643²^,³	MINT-8263049 I2D: score=2

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007498	mesoderm development	TAS	9158153
GO:0010883	regulation of lipid storage	IEA	--
GO:0032526	response to retinoic acid	IEA	--

MEST for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MEST
Search CenterWatch for drugs/clinical trials and news about MEST

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MEST gene (6 alternative transcripts):

NM_001253900.1 NM_001253901.1 NM_001253902.1 NM_002402.3 NM_177524.2 NM_177525.2

Unigene Cluster for MEST:

Mesoderm specific transcript

Hs.270978 [show with all ESTs]

Unigene Representative Sequence: AK055108

18 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000341441(uc003vqc.3 uc003vqd.3 uc022alp.1) ENST00000427521

ENST00000416162 ENST00000378576 ENST00000399874 ENST00000433159 ENST00000421001

ENST00000223215(uc011kph.2 uc003vqg.3) ENST00000437945 ENST00000460590

ENST00000437637 ENST00000458161 ENST00000462132 ENST00000475188 ENST00000494868

ENST00000463263 ENST00000488093 ENST00000393187(uc003vqf.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 3): MEST Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MEST
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate MEST (see all 26):
		hsa-miR-579 hsa-miR-4291 hsa-miR-330-5p hsa-miR-181c hsa-miR-429 hsa-miR-202 hsa-miR-29a hsa-miR-29c

		SwitchGear 3'UTR luciferase reporter plasmid: MEST 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MEST (see all 6) OriGene shRNA RFP: MEST OriGene siRNA: MEST
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEST

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEST (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEST (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): MEST (NM_177524)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEST
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEST

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MEST Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEST
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEST

Additional cDNA sequence:

AK055108.1 AK098397.1 AK298984.1 AK312688.1 BC002413.2 BC011908.2 BC014564.2 BC018695.2

BC090049.1 BT007056.1 CR457040.1 CR627364.1 D78611.1 D87367.1 Y11534.1

24/30 DOTS entries (see all 30):

DT.95328531 DT.95328621 DT.100758595 DT.95094686 DT.119948 DT.100884721 DT.100884725 DT.100884705

DT.121100666 DT.121100573 DT.97773999 DT.100709054 DT.100884731 DT.97764066 DT.100884709 DT.95269672

DT.100884697 DT.40296209 DT.75118988 DT.100757054 DT.100835318 DT.100884707 DT.121100556 DT.121100562

24/552 AceView cDNA sequences (see all 552):

AA902345 AA494531 BX108520 BM666258 F11207 AA770242 BM824977 W92519

BE467825 W95431 AI150777 AA598610 BM841421 BQ229495 NM_177525 AW069853

AI127146 AI350451 AA211924 AA305289 BC014564 AI221257 BF939939 CR611176

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for MEST (see all 16) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7a	·	7b	^	8a	·	8b	·	8c	^	9a	·	9b	^	10a	·	10b	^	11	^	12a	·	12b	·	12c	^	13	^	14a	·
SP1:							-		-		-		-		-		-		-		-						-						-										-				-
SP2:									-		-		-		-		-		-		-						-						-										-				-
SP3:																	-		-		-						-						-										-				-
SP4:							-		-		-		-		-		-		-		-						-						-										-				-
SP5:							-		-		-		-		-		-		-		-		-				-						-										-				-

ExUns:	14b	^	15a	·	15b	·	15c	^	16a	·	16b	^	17	^	18a	·	18b	·	18c	·	18d
SP1:							-		-
SP2:							-		-
SP3:							-		-
SP4:			-		-		-		-
SP5:

ECgene alternative splicing isoforms for MEST

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MEST expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGAATGTAC

About this image

MEST expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Endothelial Cells

Blood Brain Barrier, Endothelium

Brain

Blood Brain Barrier

Postnatal Endothelial Cells

Blood Brain Barrier, Endothelium

Epicardium

Kidney Endothelial Cells

Endothelium

Adipose

Visceral White Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

See MEST Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MEST

SOURCE GeneReport for Unigene cluster: Hs.270978

UniProtKB/Swiss-Prot: MEST_HUMAN, Q5EB52

Tissue specificity: Highly expressed in hydatidiform moles, but barely expressed in dermoid cysts. Biallelic expression

is detected in blood lymphocytes. Seems to imprinted in an isoform-specific manner rather than in a tissue-specific

manner in lymphocytes. Isoform 1 is expressed only from the paternal allele. Isoform 2 is expressed from both the

paternal allele and the maternal allele

SABiosciences Custom PCR Arrays for MEST

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEST

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEST

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MEST gene from 4/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mest^{1 , 5}	mesoderm specific transcript^{1, 5}	90.85(n)¹ 97.91(a)¹		6 (12.53 cM)⁵ 17294¹ NM_008590.2¹ NP_032616.1¹ 30723547⁵
chicken (Gallus gallus)	Aves	MEST¹	mesoderm specific transcript homolog (mouse)	72.6(n) 77.61(a)		427684 XM_425258.3 XP_425258.3
lizard (Anolis carolinensis)	Reptilia	MEST⁶	--	74(a)	1 ↔ 1	GL343819.1(4513-15112)
zebrafish (Danio rerio)	Actinopterygii	mest²	mesoderm specific transcript	75.53(n)		30242 BC059471.1

ENSEMBL Gene Tree for MEST (if available)
TreeFam Gene Tree for MEST (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MEST gene

MEST for paralogs About GeneDecksing

4 Pseudogenes.org Pseudogenes for MEST
PGOHUM00000246809 PGOHUM00000237974 PGOHUM00000245487 PGOHUM00000243359

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs34288832^1,2	C,	--	124507704(+)	`AAGAC-/TTTTTT`	6	--	ut3¹		2		NA CSA	4
rs78407992^1,2	C,	--	129509495(+)	`CAGATT/GACATG`	2	--	us2k¹		2		CSA WA	120
rs78916826^1,2		--	129510010(+)	`ATACCA/GGCTAT`	3	--	us2k¹		2		CSA WA	120
rs7780637^1,2	C,F,	--	129510346(+)	`gaggaT/Cgtgaa`	3	--	us2k¹		4		WA CSA NA	242
rs79448933^1,2		--	129510351(+)	`TGTGAA/GAATTA`	3	--	us2k¹		0	--	--	--	--
rs7780800^1,2	C	--	129510469(+)	`ggtgtT/Cttggg`	3	--	us2k¹		1		NA	2
rs73724319^1,2	C,	--	129510816(+)	`ATTAGG/AAATGG`	3	--	us2k¹		2		WA	120
rs76414157^1,2	C,	--	129510855(+)	`TTGGGA/TGGTAA`	3	--	us2k¹		2		CSA WA	120
rs1990787^1,2	C,F,	--	129511151(+)	`CAAATA/GTAAGG`	3	--	us2k¹		6		NA WA CSA	246
rs1990788^1,2	C,F,A,H,	--	129511252(+)	`TCGCCG/AAAGAT`	3	--	us2k¹		21		NS EA NA WA CSA	2322

HapMap Linkage Disequilibrium report for MEST (130126046 - 130146133 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MEST: --
Human Gene Mutation Database (HGMD): MEST

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MEST

DNA2.0 Custom Variant and Variant Library Synthesis for MEST

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MEST for disorders           About GeneDecksing

OMIM gene information: 601029    OMIM disorders: --

16 diseases for MEST:    About MalaCards

silver-russell syndrome beckwith-wiedemann syndrome dermoid cyst cystic nephroma

angiomyolipoma lung cancer lung adenocarcinoma pulmonary disease

leiomyoma ovarian cancer breast carcinoma adenocarcinoma

breast cancer tuberculosis carcinoma mycobacterium tuberculosis

3 diseases from the University of Copenhagen DISEASES database for MEST:

Cystic nephroma Silver-Russell syndrome Beckwith-Wiedemann syndrome

1 Novoseek disease relationship for MEST gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
growth retardation	58.8	1	9771709 (1)

Human Genome Epidemiology (HuGE) Navigator: MEST (5 documents)

Export disorders for MEST gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MEST gene, integrated from 9 sources (see all 58):
(articles sorted by number of sources associating them with MEST)

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Genomic imprinting and chromosomal localization of the human MEST gene. (PubMed id 8884280)^{1, 2, 3, 9} Nishita Y.... Takagi N. (1996)
Isoform-specific imprinting of the human PEG1/MEST gene. (PubMed id 10631159)^{1, 2} Kosaki K.... Matsuo N. (2000)
Monoallelic expression of human PEG1/MEST is paralleled by parent- specific methylation in fetuses. (PubMed id 9192843)^{1, 2} Riesewijk A.M.... Kalscheuer V.M. (1997)
Human PEG1/MEST, an imprinted gene on chromosome 7. (PubMed id 9158153)^{1, 2} Kobayashi S.... Ishino F. (1997)
PEG1 expression in maternal uniparental disomy 7. (PubMed id 9526615)^{1, 9} Cuisset L....Jeanpierre M. (1997)
Imprinting of PEG1/MEST isoform 2 in human placenta. (PubMed id 16338457)^{1, 9} McMinn J....Tycko B. (2006)
Maternal chromosome 7 hetero/isodisomy in Silver-Russell syndrome and PEG1 biallelic expression. (PubMed id 10955473)^{1, 9} Russo S....Larizza L. (2000)
Candidate DNA methylation drivers of acquired cisplati n resistance in ovarian cancer identified by methylome and expression profiling. (PubMed id 22249249)¹ Zeller C....Brown R. (2012)
Methylation and expression analyses of the 7q autism s usceptibility locus genes MEST , COPG2, and TSGA14 in human and anthropoid prima te cortices. (PubMed id 22456293)¹ Schneider E....Haaf T. (2012)
Conservation of genomic imprinting at the NDN, MAGEL2 and MEST loci in pigs. (PubMed id 22531794)¹ Zhang F.W....Wu Q. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4232	HGNC: 7028	AceView: MEST	Ensembl:ENSG00000106484	euGenes: HUgn4232
ECgene: MEST	H-InvDB: MEST

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MEST	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MEST	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for MEST gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MEST gene:
Search GeneIP for patents involving MEST

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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mesoderm specific transcript

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mesoderm specific transcript

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