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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MEST Gene

protein-coding   GIFtS: 54
GCID: GC07P130126

Mesoderm Specific Transcript

(Previous names: mesoderm specific transcript (mouse) homolog, mesoderm specific...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mesoderm Specific Transcript1 2     Mesoderm Specific Transcript Homolog (Mouse)1
PEG12 3 5     Mesoderm-Specific Transcript Homolog Protein2
Paternally-Expressed Gene 1 Protein2 3     EC 3.-.-.-3
Mesoderm Specific Transcript (Mouse) Homolog1     

External Ids:    HGNC: 70281   Entrez Gene: 42322   Ensembl: ENSG000001064847   OMIM: 6010295   UniProtKB: Q5EB523   

Export aliases for MEST gene to outside databases

Previous GC identifers: GC07P128602 GC07P129665 GC07P129679 GC07P129719 GC07P129913 GC07P124488


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MEST Gene:
This gene encodes a member of the alpha/beta hydrolase superfamily. It is imprinted, exhibiting preferential
expression from the paternal allele in fetal tissues, and isoform-specific imprinting in lymphocytes. The loss of
imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The
encoded protein may play a role in development. Alternatively spliced transcript variants encoding multiple
isoforms have been identified for this gene. Pseudogenes of this gene are located on the short arm of chromosomes
3 and 4, and the long arm of chromosomes 6 and 15. (provided by RefSeq, Dec 2011)

GeneCards Summary for MEST Gene: 
MEST (mesoderm specific transcript) is a protein-coding gene. Diseases associated with MEST include cystic nephroma, and silver-russell syndrome. GO annotations related to this gene include hydrolase activity.

Gene Wiki entry for MEST Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MEST gene promoter:
         NF-AT4   LyF-1   NF-AT   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): MEST promoter sequence
   Search SABiosciences Chromatin IP Primers for MEST

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEST


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32   Ensembl cytogenetic band:  7q32.2   HGNC cytogenetic band: 7q32

MEST Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEST gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P130126:  view genomic region     (about GC identifiers)

Start:
130,126,046 bp from pter      End:
130,146,133 bp from pter
Size:
20,088 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 129,511,449-129,531,539     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MEST_HUMAN, Q5EB52 (See protein sequence)
Recommended Name: Mesoderm-specific transcript homolog protein  
Size: 335 amino acids; 38830 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
Developmental stage: Monoallelic expression of paternally derived allele was observed in all fetal tissues
examined, including brain, skeletal muscle, kidney, adrenal, tongue, heart, skin and placenta. In 75-day fetus,
expressed in the amnion, brain, heart, lung, stomach, gut, adrenal, kidney, muscle and liver
Secondary accessions: B2R6S1 O14973 O15007 Q6AI49 Q92571
Alternative splicing: 3 isoforms:  Q5EB52-1   Q5EB52-2   Q5EB52-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MEST: NX_Q5EB52

Explore proteomics data for MEST at MOPED 

MEST Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

MEST Protein Expression

REFSEQ proteins (6 alternative transcripts): 
NP_001240829.1  NP_001240830.1  NP_001240831.1  NP_002393.2  NP_803490.1  NP_803491.1  

ENSEMBL proteins: 
 ENSP00000342749   ENSP00000409505   ENSP00000408933   ENSP00000367839   ENSP00000390589  
 ENSP00000409768   ENSP00000407222   ENSP00000223215   ENSP00000401657   ENSP00000393709  
 ENSP00000396504   ENSP00000473492   ENSP00000376884  

Human Recombinant Protein Products for MEST: 
Browse Purified and Recombinant Proteins at EMD Millipore
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Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for MEST
OriGene Protein Over-expression Lysate for MEST
OriGene MassSpec for MEST 
OriGene Custom Protein Services for MEST
GenScript Custom Purified and Recombinant Proteins Services for MEST
Novus Biologicals MEST Protein
Novus Biologicals MEST Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for MEST 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005783endoplasmic reticulum ISS--
GO:0005789endoplasmic reticulum membrane IEA--
GO:0016021integral to membrane IEA--

MEST for ontologies           About GeneDecksing



MEST Antibody Products: 
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Abcam antibodies for MEST
Cloud-Clone Corp. Antibodies for MEST 
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LSBio Antibodies in human, mouse, rat for MEST 

Assay Products for MEST: 
Browse Kits and Assays available from EMD Millipore
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GenScript Custom Assay Services for MEST
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for MEST 
Cloud-Clone Corp. CLIAs for MEST


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR000639 Epox_hydrolase-like

Graphical View of Domain Structure for InterPro Entry Q5EB52

ProtoNet protein and cluster: Q5EB52

UniProtKB/Swiss-Prot: MEST_HUMAN, Q5EB52
Similarity: Belongs to the AB hydrolase superfamily


MEST for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:
     Genatlas biochemistry entry for MEST:
mesoderm-specific transcript,expressed in fetal tissues from the paternal chromosome and in hydatidiform mole of
androgenic origin,identical to the murine imprinted gene Peg1,unlikely to be a contributor to Silver-Russell
syndrome with aberrant imprinting in invasive breast carcinomas

     Enzyme Number (IUBMB): EC 3.-.-.-1

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003824catalytic activity ----
GO:0016787hydrolase activity IEA--
     
MEST for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for MEST:
 Increased S DNA content  Upregulation of Wnt/beta-caten 

     8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mest):
 behavior/neurological  cardiovascular system  cellular  embryogenesis  growth/size 
 mortality/aging  muscle  skeleton 

MEST for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for MEST 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MEST

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MEST 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MEST 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MEST
8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate MEST (see all 26):
hsa-miR-579 hsa-miR-4291 hsa-miR-330-5p hsa-miR-181c hsa-miR-429 hsa-miR-202 hsa-miR-29a hsa-miR-29c
SwitchGear 3'UTR luciferase reporter plasmidMEST 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for MEST
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEST

Gene Editing
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DNA2.0 Custom Protein Engineering Service for MEST
Sirion Biotech Customized adenovirus for overexpression of MEST

Clone
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OriGene clones in human, mouse for MEST (see all 16)
OriGene ORF clones in mouse, rat for MEST
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): MEST (NM_177524)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEST
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEST
Sirion Biotech Customized lentivirus for stable overexpression of MEST 
                     Customized lentivirus expression plasmids for stable overexpression of MEST 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for MEST
Search LifeMap BioReagents cell lines for MEST
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEST


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MEST

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/25 Interacting proteins for MEST (Q5EB522, 3 ENSP000002232154) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
InteractantInteraction Details
GeneCardExternal ID(s)
CRELD2Q6UXH12, 3MINT-8263038 MINT-8262994 I2D: score=2 
FSTP198832, 3, ENSP000002567594MINT-8263071 I2D: score=2 STRING: ENSP00000256759
BLOC1S2Q6QNY12, 3MINT-8263005 I2D: score=2 
CEP70Q8NHQ12, 3MINT-8263016 I2D: score=2 
DBN1Q166432, 3MINT-8263049 I2D: score=2 
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007498mesoderm development TAS9158153
GO:0010883regulation of lipid storage IEA--
GO:0032526response to retinoic acid IEA--

MEST for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MEST

Search CenterWatch for drugs/clinical trials and news about MEST

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MEST gene (6 alternative transcripts): 
NM_001253900.1  NM_001253901.1  NM_001253902.1  NM_002402.3  NM_177524.2  NM_177525.2  

Unigene Cluster for MEST:

Mesoderm specific transcript
Hs.270978  [show with all ESTs]
Unigene Representative Sequence: AK055108
18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000341441(uc003vqc.3 uc003vqd.3 uc022alp.1) ENST00000427521
ENST00000416162 ENST00000378576 ENST00000399874 ENST00000433159 ENST00000421001
ENST00000223215(uc011kph.2 uc003vqg.3) ENST00000437945 ENST00000460590
ENST00000437637 ENST00000458161 ENST00000462132 ENST00000475188 ENST00000494868
ENST00000463263 ENST00000488093 ENST00000393187(uc003vqf.3)
miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MEST
8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate MEST (see all 26):
hsa-miR-579 hsa-miR-4291 hsa-miR-330-5p hsa-miR-181c hsa-miR-429 hsa-miR-202 hsa-miR-29a hsa-miR-29c
SwitchGear 3'UTR luciferase reporter plasmidMEST 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for MEST
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEST
Clone
Products:
     
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OriGene ORF clones in mouse, rat for MEST
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): MEST (NM_177524)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEST
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEST
Sirion Biotech Customized lentivirus for stable overexpression of MEST 
                     Customized lentivirus expression plasmids for stable overexpression of MEST 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for MEST
OriGene qSTAR qPCR primer pairs in human, mouse for MEST
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MEST
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEST
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEST

Additional mRNA sequence: 

AK055108.1 AK098397.1 AK298984.1 AK312688.1 BC002413.2 BC011908.2 BC014564.2 BC018695.2 
BC090049.1 BT007056.1 CR457040.1 CR627364.1 D78611.1 D87367.1 Y11534.1 

24/30 DOTS entries (see all 30):

DT.95328531  DT.95328621  DT.100758595  DT.95094686  DT.119948  DT.100884721  DT.100884725  DT.100884705 
DT.121100666  DT.121100573  DT.97773999  DT.100709054  DT.100884731  DT.97764066  DT.100884709  DT.95269672 
DT.100884697  DT.40296209  DT.75118988  DT.100757054  DT.100835318  DT.100884707  DT.121100556  DT.121100562 

24/552 AceView cDNA sequences (see all 552):

AA991769 AA902345 BX355637 AI185808 N90108 BM475319 AI362317 BM841421 
F08689 W74431 CB163993 CN482805 AI221257 CR611176 BM666258 BM675303 
AI160305 AA305289 AI280837 AI150777 BF589080 W92519 BQ229495 AW069853 

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for MEST (see all 16)    About this scheme

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a ·
SP1:                    -     -     -     -     -     -     -     -                 -                 -                             -           -               
SP2:                          -     -     -     -     -     -     -                 -                 -                             -           -               
SP3:                                                  -     -     -                 -                 -                             -           -               
SP4:                    -     -     -     -     -     -     -     -                 -                 -                             -           -               
SP5:                    -     -     -     -     -     -     -     -     -           -                 -                             -           -               

ExUns: 14b ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c · 18d
SP1:                    -     -                                       
SP2:                    -     -                                       
SP3:                    -     -                                       
SP4:        -     -     -     -                                       
SP5:                                                                  


ECgene alternative splicing isoforms for MEST

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MEST expression in normal human tissues (normalized intensities)      MEST embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTGAATGTAC
MEST Expression
About this image


MEST expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/16 selected tissues (see all 16) fully expand
 
 Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 6 entries
         ESI-049   
 
 Brain (Nervous System)    fully expand to see all 4 entries
         Endothelial Cells Blood Brain Barrier
         N2/LSB/S/F8-induced cells ( Generation of midbrain dopaminergic, forebrain and hypothalamic...
         future brain   
 
 Pancreas (Endocrine System)    fully expand to see all 3 entries
         Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
         Pancreatic endoderm/endocrine precursor-like cells ( A scalable, suspension protocol...
 
 Heart (Cardiovascular System)    fully expand to see all 2 entries
         Cardiac Fibroblasts Myocardium
         Cardiac Myocytes   
 
 Endothelium (Cardiovascular System)    fully expand to see all 2 entries
         Endothelial Cells Blood Brain Barrier

See MEST Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MEST

SOURCE GeneReport for Unigene cluster: Hs.270978

UniProtKB/Swiss-Prot: MEST_HUMAN, Q5EB52
Tissue specificity: Highly expressed in hydatidiform moles, but barely expressed in dermoid cysts. Biallelic
expression is detected in blood lymphocytes. Seems to imprinted in an isoform-specific manner rather than in a
tissue-specific manner in lymphocytes. Isoform 1 is expressed only from the paternal allele. Isoform 2 is
expressed from both the paternal allele and the maternal allele

    SABiosciences Custom PCR Arrays for MEST
Primer
Products:
OriGene qPCR primer pairs and template standards for MEST
OriGene qSTAR qPCR primer pairs in human, mouse for MEST
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MEST
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEST
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEST
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEST

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MEST gene from 4/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Mest1 , 5 mesoderm specific transcript1, 5 90.85(n)1
97.91(a)1
  6 (12.53 cM)5
172941  NM_008590.21  NP_032616.11 
 307235475 
chicken
(Gallus gallus)
Aves MEST1 mesoderm specific transcript homolog (mouse) 72.6(n)
77.61(a)
  427684  XM_425258.3  XP_425258.3 
lizard
(Anolis carolinensis)
Reptilia MEST6
Uncharacterized protein
74(a)
1 ↔ 1
GL343819.1(4513-15112)
zebrafish
(Danio rerio)
Actinopterygii mest2 mesoderm specific transcript 75.53(n)   30242  BC059471.1 


ENSEMBL Gene Tree for MEST (if available)
TreeFam Gene Tree for MEST (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for MEST gene

MEST for paralogs           About GeneDecksing


4 Pseudogenes.org Pseudogenes for MEST
PGOHUM00000246809 PGOHUM00000237974 PGOHUM00000245487 PGOHUM00000243359


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/415 SNPs in MEST are shown (see all 415)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs342888321,2
C--124507703(+) AAGAC-/TTTTTT 6 -- ut312Minor allele frequency- T:0.25NA CSA 4
rs613541551,2
C--130146327(+) AAAAG-/AAAAAA 6 -- ds50011Minor allele frequency- A:0.00NA 2
rs1895160891,2
--133467869(+) GTAATA/GTATCA 2 -- us2k10--------
rs1473621741,2
--133467905(+) ATTCAC/TATAAT 2 -- us2k10--------
rs784079921,2
C,F--133467921(+) CAGATT/GACATG 2 -- us2k12Minor allele frequency- G:0.07CSA WA 120
rs1807598811,2
--133468191(+) CCACAA/GTTTAC 3 -- us2k10--------
rs789168261,2
C,F--133468436(+) ATACCA/GGCTAT 3 -- us2k12Minor allele frequency- G:0.07CSA WA 120
rs1169792141,2
F--133468452(+) AGGCTG/AAAGCA 3 -- us2k11Minor allele frequency- A:0.01NA 120
rs1390894721,2
--133468592(+) GGACAC/TAGAAA 3 -- us2k10--------
rs14211411,2
C,F,A--133468756(+) CATGGA/GAGGCT 3 -- us2k111Minor allele frequency- G:0.46MN NA WA CSA EA 556

HapMap Linkage Disequilibrium report for MEST (130126046 - 130146133 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for MEST:    About this table     
Variant IDTypeSubtypePubMed ID
nsv831131CNV Loss17160897
nsv831130CNV Loss17160897


Human Gene Mutation Database (HGMD): MEST
SABiosciences Cancer Mutation PCR Assays
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DNA2.0 Custom Variant and Variant Library Synthesis for MEST

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 601029    OMIM disorders: --

11 diseases for MEST:    About MalaCards
cystic nephroma    silver-russell syndrome    angiomyolipoma    beckwith-wiedemann syndrome
lung adenocarcinoma    leiomyoma    tuberculosis    lung cancer
adenocarcinoma    ovarian cancer    breast cancer


MEST for disorders           About GeneDecksing

1 Novoseek inferred disease relationship for MEST gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
growth retardation 58.8 1 9771709 (1)

Genetic Association Database (GAD): MEST
Human Genome Epidemiology (HuGE) Navigator: MEST (5 documents)

Export disorders for MEST gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for MEST gene, integrated from 9 sources (see all 62):
(articles sorted by number of sources associating them with MEST)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Genomic imprinting and chromosomal localization of the human MEST gene. (PubMed id 8884280)1, 2, 3, 9 Nishita Y.... Takagi N. (1996)
  2. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
  3. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
  4. PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (2009)
  5. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (2009)
  6. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (2008)
  7. Isoform-specific imprinting of the human PEG1/MEST gene. (PubMed id 10631159)1, 2 Kosaki K.... Matsuo N. (2000)
  8. Monoallelic expression of human PEG1/MEST is paralleled by parent- specific methylation in fetuses. (PubMed id 9192843)1, 2 Riesewijk A.M.... Kalscheuer V.M. (1997)
  9. Human PEG1/MEST, an imprinted gene on chromosome 7. (PubMed id 9158153)1, 2 Kobayashi S.... Ishino F. (1997)
  10. PEG1 expression in maternal uniparental disomy 7. (PubMed id 9526615)1, 9 Cuisset L....Jeanpierre M. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 4232 HGNC: 7028 AceView: MEST Ensembl:ENSG00000106484 euGenes: HUgn4232
ECgene: MEST H-InvDB: MEST

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for MEST Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MEST Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for MEST gene:
Search GeneIP for patents involving MEST

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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