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MEST Gene

protein-coding   GIFtS: 55
GCID: GC07P130126

Mesoderm Specific Transcript

(Previous names: mesoderm specific transcript (mouse) homolog, mesoderm specific...)
  See MEST-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mesoderm Specific Transcript1 2     Mesoderm Specific Transcript Homolog (Mouse)1
PEG12 3 5     Mesoderm-Specific Transcript Homolog Protein2
Paternally-Expressed Gene 1 Protein2 3     EC 3.-.-.-3
Mesoderm Specific Transcript (Mouse) Homolog1     

External Ids:    HGNC: 70281   Entrez Gene: 42322   Ensembl: ENSG000001064847   OMIM: 6010295   UniProtKB: Q5EB523   

Export aliases for MEST gene to outside databases

Previous GC identifers: GC07P128602 GC07P129665 GC07P129679 GC07P129719 GC07P129913 GC07P124488


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MEST Gene:
This gene encodes a member of the alpha/beta hydrolase superfamily. It is imprinted, exhibiting preferential
expression from the paternal allele in fetal tissues, and isoform-specific imprinting in lymphocytes. The loss of
imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The
encoded protein may play a role in development. Alternatively spliced transcript variants encoding multiple
isoforms have been identified for this gene. Pseudogenes of this gene are located on the short arm of chromosomes
3 and 4, and the long arm of chromosomes 6 and 15. (provided by RefSeq, Dec 2011)

GeneCards Summary for MEST Gene:
MEST (mesoderm specific transcript) is a protein-coding gene. Diseases associated with MEST include silver-russell syndrome. GO annotations related to this gene include hydrolase activity.

Gene Wiki entry for MEST Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the MEST gene promoter:
         NF-AT4   LyF-1   NF-AT   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): MEST promoter sequence
   Search Chromatin IP Primers for MEST

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MEST


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32   Ensembl cytogenetic band:  7q32.2   HGNC cytogenetic band: 7q32

MEST Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEST gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P130126:  view genomic region     (about GC identifiers)

Start:
130,126,012 bp from pter      End:
130,146,133 bp from pter
Size:
20,122 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 129,511,449-129,531,539     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MEST_HUMAN, Q5EB52 (See protein sequence)
Recommended Name: Mesoderm-specific transcript homolog protein  
Size: 335 amino acids; 38830 Da
Developmental stage: Monoallelic expression of paternally derived allele was observed in all fetal tissues
examined, including brain, skeletal muscle, kidney, adrenal, tongue, heart, skin and placenta. In 75-day fetus,
expressed in the amnion, brain, heart, lung, stomach, gut, adrenal, kidney, muscle and liver
Secondary accessions: B2R6S1 O14973 O15007 Q6AI49 Q92571
Alternative splicing: 3 isoforms:  Q5EB52-1   Q5EB52-2   Q5EB52-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MEST: NX_Q5EB52

Explore proteomics data for MEST at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn163

  • See MEST Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001240829.1  NP_001240830.1  NP_001240831.1  NP_002393.2  NP_803490.1  NP_803491.1  

    ENSEMBL proteins: 
     ENSP00000342749   ENSP00000409505   ENSP00000408933   ENSP00000367839   ENSP00000390589  
     ENSP00000409768   ENSP00000407222   ENSP00000223215   ENSP00000401657   ENSP00000393709  
     ENSP00000396504   ENSP00000473492   ENSP00000376884  

    MEST Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MEST
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    OriGene MassSpec for MEST
    OriGene Custom Protein Services for MEST
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    Novus Biologicals MEST Protein
    Novus Biologicals MEST Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MEST

     
    Search eBioscience for Proteins for MEST 

    MEST Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
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    OriGene Custom Antibody Services for MEST
    Novus Biologicals MEST Antibodies
    Abcam antibodies for MEST
    Cloud-Clone Corp. Antibodies for MEST
    Search ThermoFisher Antibodies for MEST
    LSBio Antibodies in human, mouse, rat for MEST

    MEST Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MEST
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MEST
    Cloud-Clone Corp. CLIAs for MEST
    Search eBioscience for ELISAs for MEST 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000639 Epox_hydrolase-like

    Graphical View of Domain Structure for InterPro Entry Q5EB52

    ProtoNet protein and cluster: Q5EB52

    UniProtKB/Swiss-Prot: MEST_HUMAN, Q5EB52
    Similarity: Belongs to the AB hydrolase superfamily


    Find genes that share domains with MEST           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for MEST:
    mesoderm-specific transcript,expressed in fetal tissues from the paternal chromosome and in hydatidiform mole of
    androgenic origin,identical to the murine imprinted gene Peg1,unlikely to be a contributor to Silver-Russell
    syndrome with aberrant imprinting in invasive breast carcinomas

         Enzyme Number (IUBMB): EC 3.-.-.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0016787hydrolase activity IEA--
         
    Find genes that share ontologies with MEST           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MEST:
     Increased S DNA content  Upregulation of Wnt/beta-caten 

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mest):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  growth/size/body 
     mortality/aging  muscle  skeleton 

    Find genes that share phenotypes with MEST           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MEST
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MEST

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MEST
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MEST

    miRNA
    Products:
        
    miRTarBase miRNAs that target MEST:
    hsa-mir-155-5p (MIRT020968), hsa-mir-145-5p (MIRT021508)

    Block miRNA regulation of human, mouse, rat MEST using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MEST (see all 26):
    hsa-miR-579 hsa-miR-4291 hsa-miR-330-5p hsa-miR-181c hsa-miR-429 hsa-miR-202 hsa-miR-29a hsa-miR-29c
    SwitchGear 3'UTR luciferase reporter plasmidMEST 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MEST
    Predesigned siRNA for gene silencing in human, mouse, rat MEST

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MEST

    Clone
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    OriGene clones in human, mouse for MEST (see all 18)
    OriGene ORF clones in mouse, rat for MEST
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MEST (NM_177524)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEST
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEST

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MEST
    Browse ESI BIO Cell Lines and PureStem Progenitors for MEST 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEST


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MEST_HUMAN, Q5EB52: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus3
    extracellular2
    cytosol1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum ISS--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19199708

    Find genes that share ontologies with MEST           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MEST
    Interactions:

        Search GeneGlobe Interaction Network for MEST

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for MEST (Q5EB522, 3 ENSP000002232154) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRELD2Q6UXH12, 3MINT-8263038 MINT-8262994 I2D: score=2 
    FSTP198832, 3, ENSP000002567594MINT-8263071 I2D: score=2 STRING: ENSP00000256759
    BLOC1S2Q6QNY12, 3MINT-8263005 I2D: score=2 
    CEP70Q8NHQ12, 3MINT-8263016 I2D: score=2 
    DBN1Q166432, 3MINT-8263049 I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007498mesoderm development TAS9158153
    GO:0010883regulation of lipid storage IEA--
    GO:0032526response to retinoic acid IEA--

    Find genes that share ontologies with MEST           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MEST



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MEST gene (6 alternative transcripts): 
    NM_001253900.1  NM_001253901.1  NM_001253902.1  NM_002402.3  NM_177524.2  NM_177525.2  

    Unigene Cluster for MEST:

    Mesoderm specific transcript
    Hs.270978  [show with all ESTs]
    Unigene Representative Sequence: AK055108
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341441(uc003vqc.3 uc003vqd.3 uc022alp.1) ENST00000427521
    ENST00000416162 ENST00000378576 ENST00000399874 ENST00000433159 ENST00000421001
    ENST00000223215(uc011kph.2 uc003vqg.3) ENST00000437945 ENST00000460590
    ENST00000437637 ENST00000458161 ENST00000462132 ENST00000475188 ENST00000494868
    ENST00000463263 ENST00000488093 ENST00000393187(uc003vqf.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MEST using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MEST (see all 26):
    hsa-miR-579 hsa-miR-4291 hsa-miR-330-5p hsa-miR-181c hsa-miR-429 hsa-miR-202 hsa-miR-29a hsa-miR-29c
    SwitchGear 3'UTR luciferase reporter plasmidMEST 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MEST
    Predesigned siRNA for gene silencing in human, mouse, rat MEST
    Clone
    Products:
         
    OriGene clones in human, mouse for MEST (see all 18)
    OriGene ORF clones in mouse, rat for MEST
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MEST (NM_177524)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEST
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEST
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MEST
    OriGene qSTAR qPCR primer pairs in human, mouse for MEST
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MEST
      QuantiTect SYBR Green Assays in human, mouse, rat MEST
      QuantiFast Probe-based Assays in human, mouse, rat MEST

    Additional mRNA sequence: 

    AK055108.1 AK098397.1 AK298984.1 AK312688.1 BC002413.2 BC011908.2 BC014564.2 BC018695.2 
    BC090049.1 BT007056.1 CR457040.1 CR627364.1 D78611.1 D87367.1 Y11534.1 

    Selected DOTS entries (see all 30):

    DT.95328531  DT.95328621  DT.100758595  DT.95094686  DT.119948  DT.100884721  DT.100884725  DT.100884705 
    DT.121100666  DT.121100573  DT.97773999  DT.100709054  DT.100884731  DT.97764066  DT.100884709  DT.95269672 
    DT.100884697  DT.40296209  DT.75118988  DT.100757054  DT.100835318  DT.100884707  DT.121100556  DT.121100562 

    Selected AceView cDNA sequences (see all 552):

    F11207 BM795307 F11221 BC002413 NM_002402 CR598757 BM475319 CR593946 
    BF939939 CR609130 CB163993 BF589080 AI221257 AI185908 AI435142 AW069853 
    AA653287 AI097533 W80993 CR594758 AA653273 AA935387 CA407495 AI887487 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MEST (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a ·
    SP1:                    -     -     -     -     -     -     -     -                 -                 -                             -           -               
    SP2:                          -     -     -     -     -     -     -                 -                 -                             -           -               
    SP3:                                                  -     -     -                 -                 -                             -           -               
    SP4:                    -     -     -     -     -     -     -     -                 -                 -                             -           -               
    SP5:                    -     -     -     -     -     -     -     -     -           -                 -                             -           -               

    ExUns: 14b ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c · 18d
    SP1:                    -     -                                       
    SP2:                    -     -                                       
    SP3:                    -     -                                       
    SP4:        -     -     -     -                                       
    SP5:                                                                  


    ECgene alternative splicing isoforms for MEST

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MEST expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAATGTAC
    MEST Expression
    About this image


    MEST expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Endothelial Cells Blood Brain Barrier
             N2/LSB/S/F8-induced cells
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
             Floor plate-like cells
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
    MEST Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MEST Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.270978

    UniProtKB/Swiss-Prot: MEST_HUMAN, Q5EB52
    Tissue specificity: Highly expressed in hydatidiform moles, but barely expressed in dermoid cysts. Biallelic
    expression is detected in blood lymphocytes. Seems to imprinted in an isoform-specific manner rather than in a
    tissue-specific manner in lymphocytes. Isoform 1 is expressed only from the paternal allele. Isoform 2 is
    expressed from both the paternal allele and the maternal allele

        Custom PCR Arrays for MEST
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    QuantiTect SYBR Green Assays in human, mouse, rat MEST
    QuantiFast Probe-based Assays in human, mouse, rat MEST
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEST

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MEST gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mest1 , 5 mesoderm specific transcript1, 5 90.85(n)1
    97.91(a)1
      6 (12.53 cM)5
    172941  NM_008590.21  NP_032616.11 
     307235475 
    chicken
    (Gallus gallus)
    Aves MEST1 mesoderm specific transcript homolog (mouse) 72.53(n)
    77.78(a)
      427684  XM_425258.4  XP_425258.3 
    lizard
    (Anolis carolinensis)
    Reptilia MEST6
    mesoderm specific transcript
    75(a)
    1 ↔ 1
    GL343819.1(4513-15112)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mest1 mesoderm specific transcript 69.34(n)
    72.53(a)
      448261  NM_001005789.1  NP_001005789.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mest2 mesoderm specific transcript 75.53(n)   30242  BC059471.1 


    ENSEMBL Gene Tree for MEST (if available)
    TreeFam Gene Tree for MEST (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MEST gene

    Find genes that share paralogs with MEST           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for MEST
    PGOHUM00000246809 PGOHUM00000237974 PGOHUM00000245487 PGOHUM00000243359


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MEST (see all 415)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs342888321,2
    C--124507703(+) AAGAC-/TTTTTT 6 -- ut312Minor allele frequency- T:0.25NA CSA 4
    rs613541551,2
    C--130146327(+) AAAAG-/AAAAAA 6 -- ds50011Minor allele frequency- A:0.00NA 2
    rs1895160891,2
    --133467869(+) GTAATA/GTATCA 2 -- us2k10--------
    rs1473621741,2
    --133467905(+) ATTCAC/TATAAT 2 -- us2k10--------
    rs784079921,2
    C,F--133467921(+) CAGATT/GACATG 2 -- us2k12Minor allele frequency- G:0.07CSA WA 120
    rs1807598811,2
    --133468191(+) CCACAA/GTTTAC 3 -- us2k10--------
    rs789168261,2
    C,F--133468436(+) ATACCA/GGCTAT 3 -- us2k12Minor allele frequency- G:0.07CSA WA 120
    rs1169792141,2
    F--133468452(+) AGGCTG/AAAGCA 3 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1390894721,2
    --133468592(+) GGACAC/TAGAAA 3 -- us2k10--------
    rs14211411,2
    C,F,A--133468756(+) CATGGA/GAGGCT 3 -- us2k111Minor allele frequency- G:0.46MN NA WA CSA EA 556

    HapMap Linkage Disequilibrium report for MEST (130126012 - 130146133 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MEST:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831131CNV Loss17160897
    nsv831130CNV Loss17160897

    Human Gene Mutation Database (HGMD): MEST
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MEST
    DNA2.0 Custom Variant and Variant Library Synthesis for MEST

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601029    OMIM disorders: --

    1 disease for MEST:    
    About MalaCards
    silver-russell syndrome


    Find genes that share disorders with MEST           About GenesLikeMe

    1 Novoseek inferred disease relationship for MEST gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    growth retardation 58.8 1 9771709 (1)

    Genetic Association Database (GAD): MEST
    Human Genome Epidemiology (HuGE) Navigator: MEST (5 documents)

    Export disorders for MEST gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MEST gene, integrated from 10 sources (see all 65):
    (articles sorted by number of sources associating them with MEST)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic imprinting and chromosomal localization of the human MEST gene. (PubMed id 8884280)1, 2, 3, 9 Nishita Y.... Takagi N. (Genomics 1996)
    2. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    3. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    4. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    5. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    6. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    7. Isoform-specific imprinting of the human PEG1/MEST gene. (PubMed id 10631159)1, 2 Kosaki K.... Matsuo N. (Am. J. Hum. Genet. 2000)
    8. Monoallelic expression of human PEG1/MEST is paralleled by parent- specific methylation in fetuses. (PubMed id 9192843)1, 2 Riesewijk A.M.... Kalscheuer V.M. (Genomics 1997)
    9. Human PEG1/MEST, an imprinted gene on chromosome 7. (PubMed id 9158153)1, 2 Kobayashi S.... Ishino F. (Hum. Mol. Genet. 1997)
    10. PEG1 expression in maternal uniparental disomy 7. (PubMed id 9526615)1, 9 Cuisset L....Jeanpierre M. (Ann. Genet. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4232 HGNC: 7028 AceView: MEST Ensembl:ENSG00000106484 euGenes: HUgn4232
    ECgene: MEST H-InvDB: MEST

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MEST Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MEST Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MEST gene:
    Search GeneIP for patents involving MEST

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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