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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MESP2 Gene

protein-coding GIFtS: 48
GCID: GC15P090319

mesoderm posterior 2 homolog (mouse)

Explore 6 diseases affiliated with
MESP2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Mesoderm Posterior 2 Homolog (Mouse)¹ ²
SCDO2¹ ² ³ ⁵
BHLHc6¹
Class C Basic Helix-Loop-Helix Protein 6² ³
Mesoderm Posterior Protein 2²
BHLHC6³

External Ids:	HGNC: 29659¹	Entrez Gene: 145873²	Ensembl: ENSG00000188095⁷	OMIM: 605195⁵	UniProtKB: Q0VG99³

Export aliases for MESP2 gene to outside databases

Previous GC identifers: GC15P083669 GC15P087891 GC15P088049 GC15P088120 GC15P066432

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MESP2:

This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the

rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in

the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene

also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene

cause autosomal recessive spondylocostal dystosis 2 (SCD02). (provided by RefSeq, Oct 2008)

UniProtKB/Swiss-Prot: MESP2_HUMAN, Q0VG99

Function: Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite

by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of

the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a

Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a

negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is

involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm

Gene Wiki entry for MESP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010274.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MESP2 gene promoter:
COUP-TF1 NF-1/L NF-1 MAZR COUP Nkx2-5 HNF-4alpha1 COUP-TF COMP1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for MESP2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MESP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1 Ensembl cytogenetic band: 15q26.1 HGNC cytogenetic band: 15q26.1

MESP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MESP2 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P090319: view genomic region (about GC identifiers)

Start:	90,303,822 bp from pter	End:	90,321,985 bp from pter
Size:	18,164 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MESP2_HUMAN, Q0VG99 (See protein sequence)

Recommended Name: Mesoderm posterior protein 2

Size: 397 amino acids; 41760 Da

Subcellular location: Nucleus (By similarity)

Sequence caution: Sequence=DAA00304.1; Type=Erroneous gene model prediction;

Secondary accessions: Q7RTU2

Explore the universe of human proteins at neXtProt for MESP2: NX_Q0VG99

Post-translational modifications:

Degraded by the proteasome (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q0VG99

MESP2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001035047.1

ENSEMBL proteins:

ENSP00000452998 ENSP00000342392

Human Recombinant Protein Products:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MESP2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

MESP2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for MESP2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MESP2 for domains About GeneDecksing

1 InterPro domain/family:

IPR011598 HLH_dom

Graphical View of Domain Structure for InterPro Entry Q0VG99

ProtoNet protein and cluster: Q0VG99

1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

UniProtKB/Swiss-Prot: MESP2_HUMAN, Q0VG99

Similarity: Contains 1 bHLH (basic helix-loop-helix) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MESP2_HUMAN, Q0VG99

Function: Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite

by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of

the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a

Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a

negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is

involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MESP2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MESP2
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MESP2 (see all 7) OriGene shRNA RFP: MESP2 OriGene siRNA: MESP2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MESP2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MESP2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MESP2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MESP2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MESP2
		Search LifeMap BioReagents cell lines for MESP2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MESP2

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0046983	protein dimerization activity	IEA	--

MESP2 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for MESP2: Mesp2^tm1Ysa Mesp1/Mesp2^Mesp1/tm1Ysa
     11 MGI mutant phenotypes (inferred from 20 alleles) (MGI details for Mesp2):

cardiovascular system	cellular	embryogenesis	growth/size	integument
limbs/digits/tail	mortality/aging	muscle	nervous system	no phenotypic analysis
skeleton

MESP2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MESP2

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001756	somitogenesis	IEA	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0007219	Notch signaling pathway	IEA	--
GO:0008078	mesodermal cell migration	IEA	--
GO:0023019	signal transduction involved in regulation of gene expression	IEA	--

MESP2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MESP2
Search CenterWatch for drugs/clinical trials and news about MESP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MESP2 gene:

NM_001039958.1

Unigene Cluster for MESP2:

Mesoderm posterior 2 homolog (mouse)

Hs.37311 [show with all ESTs]

Unigene Representative Sequence: NM_001039958

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000560219(uc010uqa.2) ENST00000558723 ENST00000341735(uc002bon.3)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MESP2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MESP2
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MESP2 (see all 7) OriGene shRNA RFP: MESP2 OriGene siRNA: MESP2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MESP2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MESP2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MESP2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MESP2 (NM_001039958)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MESP2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MESP2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MESP2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MESP2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MESP2

Additional cDNA sequence:

AL360139.1 BC111413.1

3 DOTS entries:

DT.97785016 DT.97787427 DT.206729

18 AceView cDNA sequences:

BM715377 BQ431918 BG194549 H56469 AL360139 BG188855 W74095 BG210519

BG197584 BG186250 BG195583 BG184125 BG187796 BM665157 W79386 BG182056

BG183615 H56470

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MESP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCTCCTTTA

About this image

MESP2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Mesoderm

Cardiac progenitor Cells

Selective marker (cell-identifying gene)

Endocardium, Myocardium

Epiblast

Intraembryonic Epiblast Cells

Early Embryo

Heart

Myocardium

Cardiomyocytes Progenitor Cells

Myocardium

Lateral Plate Mesoderm

Myocardium

Early Embryo, Mesoderm

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MESP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MESP2

SOURCE GeneReport for Unigene cluster: Hs.37311

SABiosciences Custom PCR Arrays for MESP2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MESP2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MESP2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MESP2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MESP2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MESP2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MESP2 gene from 4/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mesp2^{1 , 5}	mesoderm posterior 2^{1, 5}	74.98(n)¹ 66.85(a)¹		7 (45.18 cM)⁵ 17293¹ NM_008589.2¹ NP_032615.2¹ 79810727⁵
chicken (Gallus gallus)	Aves	MESP2¹	mesoderm posterior 2 homolog (mouse)	58.42(n) 52.48(a)		395252 NM_204566.1 NP_989897.1
lizard (Anolis carolinensis)	Reptilia	--	--	51(a)	1 → many	GL344154.1(6171-57484)
zebrafish (Danio rerio)	Actinopterygii	mespaa⁶ mespba⁶ (see all 4)	mesoderm posterior ba (see all 4)	30(a) 30(a) (see all 4)	many ↔ many many ↔ many (see all 4)	7(16098653-16101163) 7(16082277-16085567)

ENSEMBL Gene Tree for MESP2 (if available)
TreeFam Gene Tree for MESP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MESP2 gene

MSGN1² MESP1²

2 SIMAP similar genes for MESP2 using alignment to 2 protein entries: MESP2_HUMAN (see all proteins):

TAL2 MESP1

MESP2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: MESP2_HUMAN, Q0VG99

Polymorphism: The number of GQ repeats at position 179 is polymorphic

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs71647809^1,2	C,	non-pathogenic	90319785(+)	`AGAGGC/GAGCCG`	2	A G	mis¹		0	--	--	--	--
rs71647808^1,2	C	pathogenic	90319895(+)	`TGCACG/TAGTTG`	2	E *	stg¹		0	--	--	--	--
rs71647806^1,2	C	pathogenic	90319961(+)	`AGACGC/GTGCGC`	2	L V	mis¹		0	--	--	--	--
rs151226454^1,2		--	90317655(+)	`TCCCTC/GGTCTT`	1	--	us2k¹		0	--	--	--	--
rs6496601^1,2	C,F,A,H,	--	90317694(+)	`CCTTTC/TCCCAA`	1	--	us2k¹ trp³		24		NS EA NA WA CSA	2346
rs189195387^1,2		--	90317726(+)	`TCTCCC/TTTAAA`	1	--	us2k¹		0	--	--	--	--
rs72754556^1,2		--	90317787(+)	`ACTATC/TCCTTA`	1	--	us2k¹		0	--	--	--	--
rs6496602^1,2	C,F,A,H,	--	90317797(+)	`ACACAA/GTCCCA`	1	--	us2k¹ tfbs³		33		NA NS EA WA CSA	2908
rs140257749^1,2		--	90317991(+)	`TTACTA/GGTTGC`	1	--	us2k¹		0	--	--	--	--
rs192208740^1,2		--	90318062(+)	`CAAGGC/TGGGTG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MESP2 (90303822 - 90321985 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MESP2: --
Human Gene Mutation Database (HGMD): MESP2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MESP2

DNA2.0 Custom Variant and Variant Library Synthesis for MESP2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MESP2 for disorders           About GeneDecksing

OMIM gene information: 605195
OMIM disorders: 608681
UniProtKB/Swiss-Prot: MESP2_HUMAN, Q0VG99

Defects in MESP2 are the cause of spondylocostal dysostosis type 2 (SCDO2) [MIM:608681]. An autosomal

recessive condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal

malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations.

Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the

malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory

insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of

life

6 diseases for MESP2: About MalaCards

spondylocostal dysostosis, autosomal recessive spondylocostal dysostosis dysostosis alagille syndrome

cadasil scoliosis

2 diseases from the University of Copenhagen DISEASES database for MESP2:

Spondylocostal dysostosis Alagille syndrome

GeneTests: MESP2

Spondylocostal Dysostosis, Autosomal Recessive

Export disorders for MESP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MESP2 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with MESP2)

Utopia: connect your pdf to the dynamic
world of online information

Transcriptional regulation of Mesp1 and Mesp2 genes: differential usage of enhancers during development. (PubMed id 11578861)^{1, 3, 9} Haraguchi S....Saga Y. (2001)
Mutations in the MESP2 gene cause spondylothoracic dysostosis/Jarcho- Levin syndrome. (PubMed id 18485326)^{1, 2} Cornier A.S.... Pourquie O. (2008)
Mutated MESP2 causes spondylocostal dysostosis in humans. (PubMed id 15122512)^{1, 2} Whittock N.V.... Turnpenny P.D. (2004)
Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening. (PubMed id 14516699)^{1, 2} McLellan A.S.... Kealey T. (2002)
Mutation analysis of MESP2, HES7 and DUSP6 gene exons in patients with congenital scoliosis. (PubMed id 22744456)¹ Qiu X.S....Qiu Y. (2012)
Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)² Zody M.C....Nusbaum C. (2006)
Cooperative Mesp activity is required for normal somitogenesis along the anterior-posterior axis. (PubMed id 16996494)¹ Morimoto M....Saga Y. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Spondylocostal Dysosto sis, Autosomal Recessive (PubMed id 20301771)¹ Turnpenny P.D....(International Consortium for Vertebral Anomalies and Scoliosis) I.C.V.A.S. (1993)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 145873	HGNC: 29659	AceView: MESP2	Ensembl:ENSG00000188095	euGenes: HUgn145873
ECgene: MESP2	H-InvDB: MESP2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MESP2	Pharmacogenomics, SNPs, Pathways
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MESP2

Intellectual Property for MESP2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MESP2 gene:
Search GeneIP for patents involving MESP2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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ThermoFisher Antibodies for MESP2

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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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MESP2 Gene

mesoderm posterior 2 homolog (mouse)

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MESP2 Gene

mesoderm posterior 2 homolog (mouse)

Aliasesfor MESP2 gene

Summariesfor MESP2 gene

Genomic Viewsfor MESP2 gene

Proteinsfor MESP2 gene

Protein Domains /Familiesfor MESP2 gene

Functionfor MESP2 gene

Pathways & Interactionsfor MESP2 gene

Drugs & Compoundsfor MESP2 gene

Transcriptsfor MESP2 gene

Expression for MESP2 gene

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Specialized Databases showing MESP2 gene

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Aliases
for MESP2 gene

Summaries
for MESP2 gene

Genomic Views
for MESP2 gene

Proteins
for MESP2 gene

Protein Domains /
Families
for MESP2 gene

Function
for MESP2 gene

Pathways & Interactions
for MESP2 gene

Drugs & Compounds
for MESP2 gene

Transcripts
for MESP2 gene

Expression
for MESP2 gene

Orthologs
for MESP2 gene

Paralogs
for MESP2 gene

Genomic Variants
for MESP2 gene

Disorders / Diseases
for MESP2 gene

Publications
for MESP2 gene

Intellectual Property
for MESP2 gene

Products
for MESP2 gene