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Aliases for MESP1 Gene

Aliases for MESP1 Gene

  • Mesoderm Posterior Basic Helix-Loop-Helix Transcription Factor 1 2 3
  • Class C Basic Helix-Loop-Helix Protein 5 3 4
  • BHLHc5 3 4
  • Mesoderm Posterior 1 Homolog (Mouse) 2
  • Mesoderm Posterior 1 Homolog 3
  • Mesoderm Posterior Protein 1 3

External Ids for MESP1 Gene

Summaries for MESP1 Gene

GeneCards Summary for MESP1 Gene

MESP1 (Mesoderm Posterior Basic Helix-Loop-Helix Transcription Factor 1) is a Protein Coding gene. Diseases associated with MESP1 include spondylocostal dysostosis. Among its related pathways are Cardiac Progenitor Differentiation. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein dimerization activity. An important paralog of this gene is MSGN1.

UniProtKB/Swiss-Prot for MESP1 Gene

  • Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MESP1 Gene

Genomics for MESP1 Gene

Genomic Location for MESP1 Gene

Start:
89,748,661 bp from pter
End:
89,751,310 bp from pter
Size:
2,650 bases
Orientation:
Minus strand

Genomic View for MESP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MESP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MESP1 Gene

Regulatory Elements for MESP1 Gene

Proteins for MESP1 Gene

  • Protein details for MESP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRJ9-MESP1_HUMAN
    Recommended name:
    Mesoderm posterior protein 1
    Protein Accession:
    Q9BRJ9
    Secondary Accessions:
    • Q9NSF1
    • Q9NSF2

    Protein attributes for MESP1 Gene

    Size:
    268 amino acids
    Molecular mass:
    28501 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The N- and C-terminal domains are separated by a 2-repeat G-Q region

neXtProt entry for MESP1 Gene

Proteomics data for MESP1 Gene at MOPED

Post-translational modifications for MESP1 Gene

No Post-translational modifications

Other Protein References for MESP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MESP1 Gene

Domains for MESP1 Gene

Gene Families for MESP1 Gene

HGNC:
  • bHLH :Basic helix-loop-helix proteins

Protein Domains for MESP1 Gene

UniProtKB/Swiss-Prot:

MESP1_HUMAN
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.:
    • Q9BRJ9
genes like me logo Genes that share domains with MESP1: view

Function for MESP1 Gene

Molecular function for MESP1 Gene

UniProtKB/Swiss-Prot Function: Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways (By similarity).

Gene Ontology (GO) - Molecular Function for MESP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 18297060
GO:0035326 enhancer binding IEA --
GO:0044212 transcription regulatory region DNA binding IDA 18297060
genes like me logo Genes that share ontologies with MESP1: view
genes like me logo Genes that share phenotypes with MESP1: view

Animal Models for MESP1 Gene

MGI Knock Outs for MESP1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for MESP1 Gene

Localization for MESP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MESP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MESP1 Gene COMPARTMENTS Subcellular localization image for MESP1 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for MESP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IC 18297060
genes like me logo Genes that share ontologies with MESP1: view

Pathways for MESP1 Gene

genes like me logo Genes that share pathways with MESP1: view

Pathways by source for MESP1 Gene

1 BioSystems pathway for MESP1 Gene

Interacting Proteins for MESP1 Gene

Gene Ontology (GO) - Biological Process for MESP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001947 heart looping ISS --
GO:0003007 heart morphogenesis --
GO:0003139 secondary heart field specification ISS --
GO:0003143 embryonic heart tube morphogenesis ISS --
GO:0003210 cardiac atrium formation IMP 18297060
genes like me logo Genes that share ontologies with MESP1: view

Transcripts for MESP1 Gene

mRNA/cDNA for MESP1 Gene

Unigene Clusters for MESP1 Gene

Mesoderm posterior 1 homolog (mouse):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MESP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b
SP1:
SP2: -

Relevant External Links for MESP1 Gene

GeneLoc Exon Structure for
MESP1
ECgene alternative splicing isoforms for
MESP1

Expression for MESP1 Gene

mRNA expression in normal human tissues for MESP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MESP1 Gene

This gene is overexpressed in Prostate (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MESP1 Gene

SOURCE GeneReport for Unigene cluster for MESP1 Gene Hs.447531

genes like me logo Genes that share expressions with MESP1: view

Orthologs for MESP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MESP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MESP1 36
  • 99.13 (n)
  • 98.88 (a)
MESP1 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MESP1 36
  • 82.42 (n)
  • 75.78 (a)
MESP1 37
  • 30 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mesp1 36
  • 74.55 (n)
  • 68.46 (a)
Mesp1 16
Mesp1 37
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MESP1 37
  • 47 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mesp1 36
  • 71.87 (n)
  • 67.51 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 26 (a)
OneToMany
MESP2 37
  • 28 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia MESP1 37
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii BX572619.4 37
  • 26 (a)
ManyToMany
mespaa 37
  • 26 (a)
ManyToMany
mespab 37
  • 25 (a)
ManyToMany
mespba 37
  • 28 (a)
ManyToMany
mespbb 37
  • 30 (a)
ManyToMany
Species with no ortholog for MESP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MESP1 Gene

ENSEMBL:
Gene Tree for MESP1 (if available)
TreeFam:
Gene Tree for MESP1 (if available)

Paralogs for MESP1 Gene

Paralogs for MESP1 Gene

Selected SIMAP similar genes for MESP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MESP1: view

Variants for MESP1 Gene

Sequence variations from dbSNP and Humsavar for MESP1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1056024 -- 89,749,984(-) CCCTT(C/T)TCAGC utr-variant-3-prime
rs2278872 -- 89,751,775(-) GGGAA(C/G)GGTCT upstream-variant-2KB
rs2305439 -- 89,750,575(-) GACCC(G/T)CCTGC reference, synonymous-codon
rs2305440 -- 89,750,563(-) CTGTT(C/G)GCCGA reference, missense
rs2305441 -- 89,750,545(-) TGCCC(G/T)GAAGG synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for MESP1 Gene

Variant ID Type Subtype PubMed ID
dgv2434n71 CNV Loss 21882294

Relevant External Links for MESP1 Gene

HapMap Linkage Disequilibrium report
MESP1
Human Gene Mutation Database (HGMD)
MESP1

Disorders for MESP1 Gene

genes like me logo Genes that share disorders with MESP1: view

No data available for UniProtKB/Swiss-Prot for MESP1 Gene

Publications for MESP1 Gene

  1. Transcriptional regulation of Mesp1 and Mesp2 genes: differential usage of enhancers during development. (PMID: 11578861) Haraguchi S. … Saga Y. (Mech. Dev. 2001) 2 3 23
  2. MesP1: a novel basic helix-loop-helix protein expressed in the nascent mesodermal cells during mouse gastrulation. (PMID: 8787751) Saga Y. … Taketo M.M. (Development 1996) 2 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3
  5. MesP1 drives vertebrate cardiovascular differentiation through Dkk-1-mediated blockade of Wnt-signalling. (PMID: 18297060) David R. … Franz W.M. (Nat. Cell Biol. 2008) 3

Products for MESP1 Gene

Sources for MESP1 Gene

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