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Aliases for MESP1 Gene

Aliases for MESP1 Gene

  • Mesoderm Posterior BHLH Transcription Factor 1 2 3 5
  • Mesoderm Posterior Basic Helix-Loop-Helix Transcription Factor 1 2 3
  • Class C Basic Helix-Loop-Helix Protein 5 3 4
  • BHLHc5 3 4
  • Mesoderm Posterior 1 Homolog (Mouse) 2
  • Mesoderm Posterior 1 Homolog 3
  • Mesoderm Posterior Protein 1 3

External Ids for MESP1 Gene

Previous GeneCards Identifiers for MESP1 Gene

  • GC15M087880
  • GC15M088022
  • GC15M088095
  • GC15M090291
  • GC15M066406

Summaries for MESP1 Gene

GeneCards Summary for MESP1 Gene

MESP1 (Mesoderm Posterior BHLH Transcription Factor 1) is a Protein Coding gene. Among its related pathways are Cardiac Progenitor Differentiation. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein dimerization activity. An important paralog of this gene is MESP2.

UniProtKB/Swiss-Prot for MESP1 Gene

  • Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MESP1 Gene

Genomics for MESP1 Gene

Regulatory Elements for MESP1 Gene

Enhancers for MESP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F089780 1.2 FANTOM5 Ensembl ENCODE 19 -32.1 -32075 6.0 PKNOX1 ARID4B SIN3A YY1 ZNF207 FOS KLF13 PAF1 ZHX2 REST MESP1 ZNF710 ENSG00000228998 NIFKP5 HAPLN3 WDR93 MESP2 PEX11A CIB1 POLG
GH15F089794 0.5 ENCODE 18.6 -43.8 -43755 0.2 NFIA GLIS1 CEBPB CEBPG RAD21 MESP1 ANPEP MESP2
GH15F089728 0.4 ENCODE 12.6 +22.9 22858 0.6 ZNF263 MESP1 WDR93 PEX11A RPL36AP43 PLIN1 GC15M089695
GH15F089839 0.9 FANTOM5 Ensembl 11.8 -88.4 -88372 1.0 CEBPA HLF CEBPB ZNF600 ZBTB17 AP3S2 MESP2 MESP1 ZNF710 CIB1 MIR5094 LOC105370965
GH15F089846 1.1 FANTOM5 Ensembl ENCODE 11.8 -98.8 -98777 6.5 BCOR ZNF146 JUN ZMYM3 FEZF1 ZNF664 ZNF316 GATA3 ZBTB48 POLR2A AP3S2 MESP1 MESP2 ANPEP PLIN1 WDR93 ZNF710 CIB1 MIR5094 LOC105370965
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MESP1 on UCSC Golden Path with GeneCards custom track

Promoters for MESP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000413259 410 1401 HDGF ATF1 PKNOX1 MLX CREB3L1 ARID4B SIN3A ZNF2 ZNF48 GLIS2

Genomic Location for MESP1 Gene

Chromosome:
15
Start:
89,748,661 bp from pter
End:
89,751,310 bp from pter
Size:
2,650 bases
Orientation:
Minus strand

Genomic View for MESP1 Gene

Genes around MESP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MESP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MESP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MESP1 Gene

Proteins for MESP1 Gene

  • Protein details for MESP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRJ9-MESP1_HUMAN
    Recommended name:
    Mesoderm posterior protein 1
    Protein Accession:
    Q9BRJ9
    Secondary Accessions:
    • Q9NSF1
    • Q9NSF2

    Protein attributes for MESP1 Gene

    Size:
    268 amino acids
    Molecular mass:
    28501 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The N- and C-terminal domains are separated by a 2-repeat G-Q region.

neXtProt entry for MESP1 Gene

Post-translational modifications for MESP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MESP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for MESP1

No data available for DME Specific Peptides for MESP1 Gene

Domains & Families for MESP1 Gene

Gene Families for MESP1 Gene

Protein Domains for MESP1 Gene

Suggested Antigen Peptide Sequences for MESP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRJ9

UniProtKB/Swiss-Prot:

MESP1_HUMAN :
  • Contains 1 bHLH (basic helix-loop-helix) domain.
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with MESP1: view

Function for MESP1 Gene

Molecular function for MESP1 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways (By similarity).

Gene Ontology (GO) - Molecular Function for MESP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IDA 18297060
GO:0035326 enhancer binding IEA --
genes like me logo Genes that share ontologies with MESP1: view
genes like me logo Genes that share phenotypes with MESP1: view

Animal Models for MESP1 Gene

MGI Knock Outs for MESP1:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MESP1 Gene

Localization for MESP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MESP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MESP1 Gene COMPARTMENTS Subcellular localization image for MESP1 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for MESP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IC 18297060
genes like me logo Genes that share ontologies with MESP1: view

Pathways & Interactions for MESP1 Gene

genes like me logo Genes that share pathways with MESP1: view

Pathways by source for MESP1 Gene

1 BioSystems pathway for MESP1 Gene

Interacting Proteins for MESP1 Gene

Gene Ontology (GO) - Biological Process for MESP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001947 heart looping IEA,ISS --
GO:0003007 heart morphogenesis IEA --
GO:0003139 secondary heart field specification IEA,ISS --
GO:0003143 embryonic heart tube morphogenesis IEA,ISS --
GO:0003210 cardiac atrium formation IMP 18297060
genes like me logo Genes that share ontologies with MESP1: view

No data available for SIGNOR curated interactions for MESP1 Gene

Transcripts for MESP1 Gene

mRNA/cDNA for MESP1 Gene

Unigene Clusters for MESP1 Gene

Mesoderm posterior 1 homolog (mouse):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MESP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b
SP1:
SP2: -

Relevant External Links for MESP1 Gene

GeneLoc Exon Structure for
MESP1
ECgene alternative splicing isoforms for
MESP1

Expression for MESP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MESP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MESP1 Gene

This gene is overexpressed in Prostate (x4.7).

Protein differential expression in normal tissues from HIPED for MESP1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MESP1 Gene



Protein tissue co-expression partners for MESP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MESP1 Gene:

MESP1

SOURCE GeneReport for Unigene cluster for MESP1 Gene:

Hs.447531
genes like me logo Genes that share expression patterns with MESP1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for MESP1 Gene

Orthologs for MESP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MESP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MESP1 34 35
  • 99.13 (n)
dog
(Canis familiaris)
Mammalia MESP1 34 35
  • 82.42 (n)
mouse
(Mus musculus)
Mammalia Mesp1 34 16 35
  • 74.55 (n)
rat
(Rattus norvegicus)
Mammalia Mesp1 34
  • 71.87 (n)
oppossum
(Monodelphis domestica)
Mammalia MESP1 35
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves MESP2 35
  • 28 (a)
OneToMany
-- 35
  • 26 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia MESP1 35
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mespbb 35
  • 30 (a)
ManyToMany
mespba 35
  • 28 (a)
ManyToMany
BX572619.4 35
  • 26 (a)
ManyToMany
mespaa 35
  • 26 (a)
ManyToMany
mespab 35
  • 25 (a)
ManyToMany
Species where no ortholog for MESP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MESP1 Gene

ENSEMBL:
Gene Tree for MESP1 (if available)
TreeFam:
Gene Tree for MESP1 (if available)

Paralogs for MESP1 Gene

Paralogs for MESP1 Gene

(1) SIMAP similar genes for MESP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MESP1: view

Variants for MESP1 Gene

Sequence variations from dbSNP and Humsavar for MESP1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1056024 -- 89,749,984(-) CCCTT(C/T)TCAGC intron-variant, utr-variant-3-prime
rs111170183 -- 89,746,197(+) TACCT(A/C)CTCAC intron-variant
rs111170184 -- 89,746,616(+) ACAGC(C/T)CCGCC intron-variant
rs111174197 -- 89,746,856(+) CCCTG(C/T)CGCCA intron-variant
rs111208019 -- 89,746,486(+) CTCTA(A/C)ACACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MESP1 Gene

Variant ID Type Subtype PubMed ID
nsv1046117 CNV gain 25217958
nsv570388 CNV loss 21841781
nsv952025 CNV deletion 24416366

Variation tolerance for MESP1 Gene

Gene Damage Index Score: 9.38; 88.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MESP1 Gene

Human Gene Mutation Database (HGMD)
MESP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MESP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MESP1 Gene

Disorders for MESP1 Gene

Relevant External Links for MESP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MESP1

No disorders were found for MESP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MESP1 Gene

Publications for MESP1 Gene

  1. Transcriptional regulation of Mesp1 and Mesp2 genes: differential usage of enhancers during development. (PMID: 11578861) Haraguchi S. … Saga Y. (Mech. Dev. 2001) 2 3 22 64
  2. MesP1: a novel basic helix-loop-helix protein expressed in the nascent mesodermal cells during mouse gastrulation. (PMID: 8787751) Saga Y. … Taketo M.M. (Development 1996) 2 3 64
  3. Dual reporter MESP1 mCherry/w-NKX2-5 eGFP/w hESCs enable studying early human cardiac differentiation. (PMID: 25187301) Den Hartogh S.C. … Passier R. (Stem Cells 2015) 3 64
  4. Mutational analysis of the human MESP1 gene in patients with congenital heart disease reveals a highly variable sequence in exon 1. (PMID: 24056064) Lahm H. … Krane M. (Eur J Med Genet 2013) 3 64
  5. Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors. (PMID: 22826236) Islas J.F. … Schwartz R.J. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3 64

Products for MESP1 Gene

Sources for MESP1 Gene

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