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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MESP1 Gene

protein-coding GIFtS: 46
GCID: GC15M090291

mesoderm posterior 1 homolog (mouse)

Explore 3 diseases affiliated with
MESP1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Mesoderm Posterior 1 Homolog (Mouse)¹ ²
BHLHc5¹
Class C Basic Helix-Loop-Helix Protein 5² ³
MGC10676¹
Mesoderm Posterior Protein 1²
BHLHC5³

External Ids:	HGNC: 29658¹	Entrez Gene: 55897²	Ensembl: ENSG00000166823⁷	OMIM: 608689⁵	UniProtKB: Q9BRJ9³

ORGUL members:
	NONCODE:n338119

Export aliases for MESP1 gene to outside databases

Previous GC identifers: GC15M087880 GC15M088022 GC15M088095 GC15M066406

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MESP1_HUMAN, Q9BRJ9

Function: Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of

cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways (By

similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010274.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MESP1 gene promoter:
HOXA9 AhR HOXA9B HTF Lmo2 Meis-1a Nkx2-5 Meis-1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for MESP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MESP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1 Ensembl cytogenetic band: 15q26.1 HGNC cytogenetic band: 15q26.1

MESP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MESP1 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M090291: view genomic region (about GC identifiers)

Start:	90,291,892 bp from pter	End:	90,294,541 bp from pter
Size:	2,650 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MESP1_HUMAN, Q9BRJ9 (See protein sequence)

Recommended Name: Mesoderm posterior protein 1

Size: 268 amino acids; 28501 Da

Subcellular location: Nucleus (Probable)

Miscellaneous: The N- and C-terminal domains are separated by a 2-repeat G-Q region

Secondary accessions: Q9NSF1 Q9NSF2

Explore the universe of human proteins at neXtProt for MESP1: NX_Q9BRJ9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BRJ9

MESP1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_061140.1

ENSEMBL proteins:

ENSP00000300057

Human Recombinant Protein Products for MESP1:

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	Browse Sino Biological Recombinant Proteins
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	Uscn Proteins for MESP1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IC	18297060

MESP1 for ontologies About GeneDecksing

MESP1 Antibody Products:

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Assay Products for MESP1:

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	GenScript Custom Assay Services for MESP1
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	Uscn ELISAs and CLIAs for MESP1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MESP1 for domains About GeneDecksing

1 InterPro domain/family:

IPR011598 HLH_dom

Graphical View of Domain Structure for InterPro Entry Q9BRJ9

ProtoNet protein and cluster: Q9BRJ9

1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

UniProtKB/Swiss-Prot: MESP1_HUMAN, Q9BRJ9

Similarity: Contains 1 bHLH (basic helix-loop-helix) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MESP1_HUMAN, Q9BRJ9

Function: Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of

cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways (By

similarity)

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	sequence-specific DNA binding transcription factor activity	IDA	18297060
GO:0035326	enhancer binding	IEA	--
GO:0044212	transcription regulatory region DNA binding	IDA	18297060
GO:0046983	protein dimerization activity	IEA	--

MESP1 for ontologies About GeneDecksing

Phenotypes:
14 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Mesp1):

cardiovascular system	cellular	craniofacial	embryogenesis	growth/size
hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	mortality/aging
muscle	nervous system	respiratory system	skeleton

MESP1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for MESP1: Mesp1^tm4Ysa Mesp1^tm3Ysa Mesp1/Mesp2^Mesp1/tm1Ysa

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MESP1

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MESP1
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate MESP1:
		hsa-miR-3926 hsa-miR-513b
		SwitchGear 3'UTR luciferase reporter plasmid: MESP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MESP1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MESP1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for MESP1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MESP1

Gene Ontology (GO): 5/33 biological process terms (GO ID links to tree view) (see all 33): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001947	heart looping	ISS	--
GO:0003007	heart morphogenesis	--	--
GO:0003139	secondary heart field specification	ISS	--
GO:0003143	embryonic heart tube morphogenesis	ISS	--
GO:0003210	cardiac atrium formation	IMP	18297060

MESP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MESP1
Search CenterWatch for drugs/clinical trials and news about MESP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MESP1 gene:

NM_018670.3

Unigene Cluster for MESP1:

Mesoderm posterior 1 homolog (mouse)

Hs.447531 [show with all ESTs]

Unigene Representative Sequence: AL357535

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000300057(uc002bol.3) ENST00000559894

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MESP1
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate MESP1:
		hsa-miR-3926 hsa-miR-513b
		SwitchGear 3'UTR luciferase reporter plasmid: MESP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MESP1 (see all 7) OriGene shRNA RFP: MESP1 OriGene siRNA: MESP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MESP1
		Sirion Biotech Custom design and validation of potent shRNA sequences against MESP1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MESP1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MESP1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MESP1 (NM_018670)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MESP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MESP1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MESP1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MESP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MESP1

Additional cDNA sequence:

AL357533.1 AL357534.1 AL357535.1 AL357570.1 AL357571.1 BC006219.1

2 DOTS entries:

DT.201847 DT.86853082

24/48 AceView cDNA sequences (see all 48):

AI160116 AI973116 BC006219 BE794535 AI361605 AI797472 NM_018670 AL357534

CK826088 AL357535 AW295958 BI759784 AW135833 AI825438 BF514903 AI096885

BM995554 BQ417147 BF526448 BM845762 AI969913 AI954630 AI635386 AI991102

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for MESP1 About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b
SP1:
SP2:					-

ECgene alternative splicing isoforms for MESP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MESP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGGGACCCA

About this image

MESP1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/11 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 11)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Head Mesenchyme

Paraxial Mesoderm Cells

Selective marker (cell-identifying gene)

Bone, Skeletal Muscle

Mesoderm

Cardiac progenitor Cells

Endocardium, Myocardium

Skeletal Muscle

Extraocular Muscles

Muscle satellite Cells

Skeletal Muscle

Epiblast

Intraembryonic Epiblast Cells

Early Embryo

Head Mesenchyme

Branchial Arch 1

Paraxial Mesoderm Cells

Bone, Skeletal Muscle

Head Mesenchyme

Branchial Arch 2

Paraxial Mesoderm Cells

Skeletal Muscle

Heart

Myocardium

Cardiomyocytes Progenitor Cells

Myocardium

Lateral Plate Mesoderm

Myocardium

Early Embryo, Mesoderm

Paraxial Mesoderm

Paraxial Mesoderm Cells

Mesoderm

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10/14 LifeMap Cells (see all 14)

Name

Category

Early mesoderm cells (Generation of human ...)

Mesodermal embryoid bodies (Cardiomyocyte genera...)

Mesoderm-like cells (Derivation of cardio...)

Mesoderm embryoid bodies (Promotion of cardiom...)

BMP4-induced embryoid bodies (Cardiac differentiat...)

Paraxial mesoderm cells (Generation of human ...)

Cardiomyocyte-like cells (Cardiomyocyte genera...)

Cardiac mesoderm embryoid bodies (Cardiomyocyte genera...)

Cardiomyocyte-like progenitor cells (Derivation of cardio...)

Matrigel embedded cells (Derivation of cardio...)

See MESP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MESP1

SOURCE GeneReport for Unigene cluster: Hs.447531

SABiosciences Custom PCR Arrays for MESP1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MESP1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MESP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MESP1

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for MESP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MESP1 gene from 3/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MESP2⁶	Uncharacterized protein	28(a)	1 → many	10(22173500-22174778)
lizard (Anolis carolinensis)	Reptilia	--	--	55(a)	1 → many	GL344154.1(6171-57484)
zebrafish (Danio rerio)	Actinopterygii	mespab⁶ mespba⁶ (see all 4)	mesoderm posterior ba (see all 4)	29(a) 28(a) (see all 4)	many ↔ many many ↔ many (see all 4)	25(11382068-11383326) 7(16082277-16085567)

ENSEMBL Gene Tree for MESP1 (if available)
TreeFam Gene Tree for MESP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MESP1 gene

MSGN1² MESP2²

1 SIMAP similar gene for MESP1 using alignment to 1 protein entry: MESP1_HUMAN:

MESP2

MESP1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3743115^1,2	C,F,A,H	--	90292611(-)	`TCCTGT/GGGTCT`	1	--	int¹		25		EA NS NA WA CSA	3842
rs188128385^1,2		--	90292851(+)	`AGTTCC/TCCACC`	1	--	int¹		0	--	--	--	--
rs182039091^1,2		--	90292903(+)	`TTCTCA/TCAGGA`	1	--	int¹		0	--	--	--	--
rs74508326^1,2		--	90292904(+)	`TCTCAC/TAGGAC`	1	--	int¹		2		CSA WA	119
rs149597091^1,2		--	90292910(+)	`AGGACA/GTCCCT`	1	--	int¹		0	--	--	--	--
rs77087830^1,2	F	--	90292924(+)	`CACCCA/CTTCCA`	1	--	int¹		1		WA	118
rs4932141^1,2	C,F,A,H	--	90292934(+)	`AGGCTC/GACCCA`	1	--	int¹		11		NA WA CSA EA	374
rs145627061^1,2		--	90292966(+)	`GGGCT-/GGGGGT`	1	--	int¹		0	--	--	--	--
rs76902989^1,2	F	--	90293002(+)	`GGGGTC/GGGGGG`	1	--	int¹		1		WA	118
rs185608291^1,2		--	90293008(+)	`GGGGGA/GCTAAA`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MESP1 (90291892 - 90294541 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MESP1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MESP1

DNA2.0 Custom Variant and Variant Library Synthesis for MESP1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MESP1 for disorders           About GeneDecksing

OMIM gene information: 608689    OMIM disorders: --

3 diseases for MESP1:    About MalaCards

spondylocostal dysostosis dysostosis sinusitis

Export disorders for MESP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MESP1 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with MESP1)

Utopia: connect your pdf to the dynamic
world of online information

Transcriptional regulation of Mesp1 and Mesp2 genes: differential usage of enhancers during development. (PubMed id 11578861)^{1, 3, 9} Haraguchi S....Saga Y. (2001)
MesP1: a novel basic helix-loop-helix protein expressed in the nascent mesodermal cells during mouse gastrulation. (PubMed id 8787751)^{1, 3} Saga Y....Taketo M.M. (1996)
Transcription factors ETS2 and MESP1 transdifferentiat e human dermal fibroblasts into cardiac progenitors. (PubMed id 22826236)¹ Islas J.F....Schwartz R.J. (2012)
MesP1 drives vertebrate cardiovascular differentiation through Dkk-1-mediated blockade of Wnt-signalling. (PubMed id 18297060)¹ David R....Franz W.M. (2008)
Mutated MESP2 causes spondylocostal dysostosis in humans. (PubMed id 15122512)² Whittock N.V.... Turnpenny P.D. (2004)
Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)¹ Suzuki Y.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Mesp1 coordinately regulates cardiovascular fate restriction and epithelial-mesenchymal transition in differentiating ESCs. (PubMed id 18593559)⁹ Lindsley R.C....Murphy K.M. (2008)
Generation of functional murine cardiac myocytes from induced pluripotent stem cells. (PubMed id 18625890)⁹ Mauritz C....Martin U. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55897	HGNC: 29658	AceView: MESP1	Ensembl:ENSG00000166823	euGenes: HUgn55897
ECgene: MESP1	H-InvDB: MESP1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MESP1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MESP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MESP1 gene:
Search GeneIP for patents involving MESP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MESP1
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Search for Antibodies & Assays

	Regulatory tfbs in MESP1 promoter
	Search Chromatin IP Primers for MESP1
	RT² qPCR Primer Assay in human, mouse, rat MESP1
	GNC Network for MESP1
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Search Tocris compounds for MESP1

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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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MESP1 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for MESP1

	Gene Synthesis
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Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for MESP1

	SwitchGear 3'UTR luciferase reporter plasmids for MESP1
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ThermoFisher Antibodies for MESP1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MESP1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MESP1

Sirion Biotech Customized:

	stable knockdown cell line services for MESP1
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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MESP1 Gene

mesoderm posterior 1 homolog (mouse)

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MESP1 Gene

mesoderm posterior 1 homolog (mouse)

Aliasesfor MESP1 gene

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Genomic Viewsfor MESP1 gene

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Protein Domains /Familiesfor MESP1 gene

Functionfor MESP1 gene

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Genome Databases showing MESP1 gene

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Specialized Databases showing MESP1 gene

Intellectual Propertyfor MESP1 gene

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Summaries
for MESP1 gene

Genomic Views
for MESP1 gene

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Families
for MESP1 gene

Function
for MESP1 gene

Pathways & Interactions
for MESP1 gene

Drugs & Compounds
for MESP1 gene

Transcripts
for MESP1 gene

Expression
for MESP1 gene

Orthologs
for MESP1 gene

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for MESP1 gene

Genomic Variants
for MESP1 gene

Disorders / Diseases
for MESP1 gene

Publications
for MESP1 gene

Intellectual Property
for MESP1 gene

Products
for MESP1 gene