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MESDC2 Gene

protein-coding   GIFtS: 54
GCID: GC15M081244

Mesoderm Development Candidate 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mesoderm Development Candidate 21 2 3     BOCA2 5
MESD2 3 5     KIAA00813 5
Mesoderm Development Protein2 3     LDLR Chaperone MESD2
Renal Carcinoma Antigen NY-REN-612 3     

External Ids:    HGNC: 135201   Entrez Gene: 231842   Ensembl: ENSG000001178997   OMIM: 6077835   UniProtKB: Q146963   

Export aliases for MESDC2 gene to outside databases

Previous GC identifers: GC15M077196 GC15M074396 GC15M078815 GC15M078955 GC15M078983 GC15M079026 GC15M058026


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MESDC2 Gene:
MESDC2 (mesoderm development candidate 2) is a protein-coding gene. GO annotations related to this gene include low-density lipoprotein particle receptor binding.

UniProtKB/Swiss-Prot: MESD_HUMAN, Q14696
Function: Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of
low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the
coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of
embryonic polarity and mesoderm induction

Gene Wiki entry for MESDC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the MESDC2 gene promoter:
         Pax-5   SREBP-1c   SREBP-1b   CREB   E2F   SREBP-1a   deltaCREB   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMESDC2 promoter sequence
   Search Chromatin IP Primers for MESDC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MESDC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q13   Ensembl cytogenetic band:  15q25.1   HGNC cytogenetic band: 15q13

MESDC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MESDC2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M081244:  view genomic region     (about GC identifiers)

Start:
81,239,667 bp from pter      End:
81,282,219 bp from pter
Size:
42,553 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MESD_HUMAN, Q14696 (See protein sequence)
Recommended Name: LDLR chaperone MESD precursor  
Size: 234 amino acids; 26077 Da
Subunit: Monomer (By similarity). Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and
chaperones LRP6 to the plasma membrane. Interacts with LRP6; the interaction prevents LRP6 from forming
aggregates and chaperones LRP6 to the plasma membrane
Sequence caution: Sequence=BAA07640.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: D3DW96 Q969U1

Explore the universe of human proteins at neXtProt for MESDC2: NX_Q14696

Explore proteomics data for MESDC2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Ser88, Asn201
  • Modification sites at PhosphoSitePlus

  • See MESDC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055969.1  
    ENSEMBL proteins: 
     ENSP00000453430   ENSP00000403839   ENSP00000453220   ENSP00000261758  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019330 Mesoderm_development_cand-2

    Graphical View of Domain Structure for InterPro Entry Q14696

    ProtoNet protein and cluster: Q14696

    UniProtKB/Swiss-Prot: MESD_HUMAN, Q14696
    Domain: The chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of
    LRP5/6 (By similarity)
    Domain: The escort domain ensures LRP5/6 safe-trafficking from the ER to the Golgi by preventing premature
    ligand-binding (By similarity)
    Similarity: Belongs to the MESD family


    Find genes that share domains with MESDC2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MESD_HUMAN, Q14696
    Function: Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of
    low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the
    coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of
    embryonic polarity and mesoderm induction

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0050750low-density lipoprotein particle receptor binding IEA--
         
    Find genes that share ontologies with MESDC2           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Mesdc2):
     embryogenesis 

    Find genes that share phenotypes with MESDC2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MESDC2: Mesdc2tm1Lex Mesdc2tm1Bch

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MESDC2
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MESDC2

    miRNA
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    miRTarBase miRNAs that target MESDC2:
    hsa-mir-222-3p (MIRT046719), hsa-mir-124-3p (MIRT022467), hsa-mir-15b-5p (MIRT046420), hsa-mir-26b-5p (MIRT029302), hsa-mir-186-5p (MIRT021164)

    Block miRNA regulation of human, mouse, rat MESDC2 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate MESDC2:
    hsa-miR-4261 hsa-miR-2116 hsa-miR-590-3p hsa-miR-3622a-5p
    SwitchGear 3'UTR luciferase reporter plasmidMESDC2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MESDC2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MESD_HUMAN, Q14696: Endoplasmic reticulum
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular3
    plasma membrane2
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005783endoplasmic reticulum IEA--
    GO:0005886plasma membrane IEA--

    Find genes that share ontologies with MESDC2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MESDC2 About    
    See pathways by source

    SuperPathContained pathways About
    1Non-Canonical Wnt Pathway
    Non-Canonical Wnt Pathway0.53
    Canonical Wnt Pathway0.53
    2Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch


    Find genes that share SuperPaths with MESDC2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for MESDC2
        Wnt / Hedgehog / Notch

    2 Sino Biological Pathways for MESDC2
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MESDC2
    Interactions:

        GeneGlobe Interaction Network for MESDC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MESDC2 (Q146962, 3 ENSP000002617584) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP6V1E1P365432, 3, ENSP000002534134MINT-8262902 I2D: score=2 STRING: ENSP00000253413
    BRD4O608852, 3, ENSP000002633774MINT-8262917 I2D: score=2 STRING: ENSP00000263377
    KPNB1Q149742, 3, ENSP000002901584MINT-8262929 I2D: score=2 STRING: ENSP00000290158
    SNX5Q9Y5X32, 3MINT-8262972 I2D: score=2 
    PSMA5P280662, 3, ENSP000002713084MINT-8262940 I2D: score=2 STRING: ENSP00000271308
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding ISS--
    GO:0007498mesoderm development NAS11247670
    GO:0016055Wnt signaling pathway IEA--
    GO:0034394protein localization to cell surface IEA--

    Find genes that share ontologies with MESDC2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MESDC2 (MESD)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MESDC2 gene: 
    NM_015154.1  

    Unigene Cluster for MESDC2:

    Mesoderm development candidate 2
    Hs.578450  [show with all ESTs]
    Unigene Representative Sequence: NM_015154
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000561312(uc002bfx.3 uc010uno.2) ENST00000422879 ENST00000560244
    ENST00000560189 ENST00000559537 ENST00000261758(uc002bfy.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat MESDC2 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate MESDC2:
    hsa-miR-4261 hsa-miR-2116 hsa-miR-590-3p hsa-miR-3622a-5p
    SwitchGear 3'UTR luciferase reporter plasmidMESDC2 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat MESDC2
      QuantiFast Probe-based Assays in human, mouse, rat MESDC2

    Additional mRNA sequence: 

    AK026606.1 AK301416.1 AY359110.1 D42039.2 

    9 DOTS entries:

    DT.116495  DT.121015432  DT.91706602  DT.121015421  DT.75192905  DT.100031165  DT.100777020  DT.95108871 
    DT.304678 

    Selected AceView cDNA sequences (see all 309):

    BU785438 AA514473 AA457481 BE384248 BQ880237 CR611437 AW401694 BM753518 
    CA848483 BM561633 BC007867 AA825146 AI621024 AI816373 AI141064 CK430925 
    BU785741 BE349337 BM690297 BU726826 AI095694 BU501406 BC009210 BI759489 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MESDC2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
    SP1:                                          
    SP2:                                          
    SP3:                                -         


    ECgene alternative splicing isoforms for MESDC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MESDC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGGTTCTCT
    MESDC2 Expression
    About this image

    MESDC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MESDC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.578450
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MESDC2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mesdc21 , 5 mesoderm development candidate 21, 5 82.59(n)1
    84.37(a)1
      7 (48.35 cM)5
    679431  NM_023403.31  NP_075892.31 
     838844665 
    chicken
    (Gallus gallus)
    Aves MESDC21 mesoderm development candidate 2 71.47(n)
    75.48(a)
      415475  NM_001030551.1  NP_001025722.1 
    lizard
    (Anolis carolinensis)
    Reptilia MESDC26
    mesoderm development candidate 2
    74(a)
    1 ↔ 1
    GL343332.1(825629-832350)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.257322 Xenopus laevis transcribed sequence with weak similarity more 82.42(n)    BJ625696.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mesdc21 mesoderm development candidate 2 75.41(n)
    83.61(a)
      791222  NM_001080704.1  NP_001074173.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta boca1 boca 57.24(n)
    50(a)
      48986  NM_165541.2  NP_724578.1 
    worm
    (Caenorhabditis elegans)
    Secernentea bmy-11 bmy-1 49.31(n)
    43.75(a)
      173908  NM_062602.2  NP_495003.2 


    ENSEMBL Gene Tree for MESDC2 (if available)
    TreeFam Gene Tree for MESDC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MESDC2 gene

    Find genes that share paralogs with MESDC2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for MESDC2
    PGOHUM00000239756


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MESDC2 (see all 403)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1393838641,2
    --81267623(+) CGGGAC/GGCTGA 1 -- ds50010--------
    rs1441655401,2
    --81267630(+) CTGAGA/GCAAGA 1 -- ds50010--------
    rs1871817921,2
    --81267672(+) AGTGAA/GCTATG 1 -- ds50010--------
    rs1924829881,2
    --81267697(+) CTCTAG/TCCTGA 1 -- ds50010--------
    rs1464820981,2
    --81267734(+) TAAAAA/GACAAA 1 -- ds50010--------
    rs351391991,2
    C,F--81267924(+) TTTCCC/ATTGTT 1 -- ds50012Minor allele frequency- A:0.05NA 122
    rs1399412191,2
    --81268057(+) TGAAGA/GAGGAA 1 -- ds50010--------
    rs1442906071,2
    --81268115(+) TCATCC/TAAATT 1 -- ut310--------
    rs1452232191,2
    C--81268272(+) CTGCAC/TTCTAG 1 -- ut310--------
    rs71825491,2
    C,F,H--81268287(+) ggcaaC/Aagagt 1 -- ut3114Minor allele frequency- A:0.08NS EA NA WA 1878

    HapMap Linkage Disequilibrium report for MESDC2 (81239667 - 81282219 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MESDC2: --
    Human Gene Mutation Database (HGMD): MESDC2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MESDC2
    DNA2.0 Custom Variant and Variant Library Synthesis for MESDC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607783    OMIM disorders: --


    Find genes that share disorders with MESDC2           About GenesLikeMe


    Export disorders for MESDC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MESDC2 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with MESDC2)
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    1. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7788527)1, 2, 3 Nagase T.... Nomura N. (DNA Res. 1995)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    5. Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis. (PubMed id 11247670)1, 3 Wines M.E.... Holdener B.C. (Genomics 2001)
    6. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (Int. J. Cancer 1999)
    7. Fusion of the SUMO/Sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a patient with an infantile teratoma and a constitutional t(12;15)(q13;q25). (PubMed id 15917269)1, 9 Veltman I.M....van Kessel A.G. (Hum. Mol. Genet. 2005)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. The C-terminal region Mesd peptide mimics full-length Mesd and acts as an inhibitor of Wnt/I^-catenin signaling in cancer cells. (PubMed id 23469146)1 Lin C....Li Y. (PLoS ONE 2013)
    10. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23184 HGNC: 13520 AceView: MESDC2 Ensembl:ENSG00000117899 euGenes: HUgn23184
    ECgene: MESDC2 H-InvDB: MESDC2

    (According to HUGE)
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    HUGE: KIAA0081

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MESDC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MESDC2 gene:
    Search GeneIP for patents involving MESDC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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