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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MESDC2 Gene

protein-coding   GIFtS: 54
GCID: GC15M081244

mesoderm development candidate 2
 Explore 9 diseases affiliated with
MESDC2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MESDC2    

Aliases
for MESDC2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mesoderm Development Candidate 21 2 3     Mesoderm Development Protein2 3
MESD1 2 3 5     Renal Carcinoma Antigen NY-REN-612 3
BOCA1 2 5     LDLR Chaperone MESD2
KIAA00811 3 5     

External Ids:    HGNC: 135201   Entrez Gene: 231842   Ensembl: ENSG000001178997   OMIM: 6077835   UniProtKB: Q146963   

Export aliases for MESDC2 gene to outside databases

Previous GC identifers: GC15M077196 GC15M074396 GC15M078815 GC15M078955 GC15M078983 GC15M079026 GC15M058026


Summaries
for MESDC2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: MESD_HUMAN, Q14696
Function: Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density
lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the
canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and
mesoderm induction

Gene Wiki entry for MESDC2


Genomic Views
for MESDC2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MESDC2 gene promoter:
         Pax-5   SREBP-1c   SREBP-1b   CREB   E2F   SREBP-1a   deltaCREB   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MESDC2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MESDC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MESDC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q13   Ensembl cytogenetic band:  15q25.1   HGNC cytogenetic band: 15q13

MESDC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MESDC2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M081244:  view genomic region     (about GC identifiers)

Start:
 81,239,667 bp from pter      End:
 81,282,219 bp from pter
Size:
 42,553 bases      Orientation:
 minus strand

Proteins
for MESDC2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MESD_HUMAN, Q14696 (See protein sequence)
Recommended Name: LDLR chaperone MESD precursor  
Size: 234 amino acids; 26077 Da
Subunit: Monomer (By similarity). Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and
chaperones LRP6 to the plasma membrane. Interacts with LRP6; the interaction prevents LRP6 from forming aggregates and
chaperones LRP6 to the plasma membrane
Subcellular location: Endoplasmic reticulum
Sequence caution: Sequence=BAA07640.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: D3DW96 Q969U1

Explore the universe of human proteins at neXtProt for MESDC2: NX_Q14696

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14696

    • MESDC2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055969.1  
    ENSEMBL proteins: 
     ENSP00000453430   ENSP00000403839   ENSP00000453220   ENSP00000261758  

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    Sino Biological Recombinant Protein for MESDC2
    ProSpec Recombinant Protein for MESDC2
    Uscn Proteins for MESDC2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005783endoplasmic reticulum IEA--
    GO:0005886plasma membrane IEA--


    MESDC2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for MESDC2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MESDC2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR019330 Mesoderm_development_cand-2

    Graphical View of Domain Structure for InterPro Entry Q14696

    ProtoNet protein and cluster: Q14696

    UniProtKB/Swiss-Prot: MESD_HUMAN, Q14696
    Domain: The chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of
    LRP5/6 (By similarity)
    Domain: The escort domain ensures LRP5/6 safe-trafficking from the ER to the Golgi by preventing premature
    ligand-binding (By similarity)
    Similarity: Belongs to the MESD family


    Function
    for MESDC2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MESD_HUMAN, Q14696
    Function: Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density
    lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the
    canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and
    mesoderm induction

    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate MESDC2:
    hsa-miR-4261 hsa-miR-2116 hsa-miR-590-3p hsa-miR-3622a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: MESDC2 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: MESDC2
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0050750low-density lipoprotein particle receptor binding IEA--


    MESDC2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for MESDC2: Mesdc2tm1Lex Mesdc2tm1Bch
         1 MGI mutant phenotype (inferred from 2 alleles) (MGI details for Mesdc2):
     embryogenesis 

    MESDC2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MESDC2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Wnt / Hedgehog / Notch
    		Wnt / Hedgehog / Notch1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for MESDC2
        Wnt / Hedgehog / Notch



    MESDC2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MESDC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/34 Interacting proteins for MESDC2 (Q146962, 3 ENSP000002617584) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP6V1E1P365432, 3, ENSP000002534134MINT-8262902 I2D: score=2 STRING: ENSP00000253413
    BRD4O608852, 3, ENSP000002633774MINT-8262917 I2D: score=2 STRING: ENSP00000263377
    KPNB1Q149742, 3, ENSP000002901584MINT-8262929 I2D: score=2 STRING: ENSP00000290158
    SNX5Q9Y5X32, 3MINT-8262972 I2D: score=2 
    PSMA5P280662, 3, ENSP000002713084MINT-8262940 I2D: score=2 STRING: ENSP00000271308
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding ISS--
    GO:0007498mesoderm development NAS11247670
    GO:0016055Wnt receptor signaling pathway IEA--
    GO:0034394protein localization to cell surface IEA--


    MESDC2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MESDC2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MESDC2
    Search CenterWatch for drugs/clinical trials and news about MESDC2 / MESD 

    Transcripts
    for MESDC2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MESDC2 gene: 
    NM_015154.1  

    Unigene Clusters for MESDC2:

    Mesoderm development candidate 2
    Hs.578450  [show with all ESTs], Hs.732380  [show with all ESTs]
    Unigene Representative Sequences: NM_015154, BC009210
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000561312(uc002bfx.3 uc010uno.2) ENST00000422879 ENST00000560244
    ENST00000560189 ENST00000559537 ENST00000261758(uc002bfy.1)

    miRNA
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    hsa-miR-4261 hsa-miR-2116 hsa-miR-590-3p hsa-miR-3622a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: MESDC2 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    BC007867.2 BC009210.2 BC012746.2 

    13 DOTS entries:

    DT.116495  DT.121015432  DT.91706602  DT.406518  DT.121015421  DT.75192905  DT.92437859  DT.95108871 
    DT.97855262  DT.100031165  DT.100777020  DT.91811846  DT.304678 

    24/309 AceView cDNA sequences (see all 309):

    BX096131 AI816373 BI756064 BM683070 CR611437 BM782583 AW961831 BE384248 
    AA888803 BU952431 AL109667 AI743081 AI201392 AI141064 AA306061 AI621024 
    D42039 BM753518 T09141 H24711 AA457481 AA150401 AW518954 BM690297 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MESDC2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
    SP1:                                          
    SP2:                                          
    SP3:                                -         


    ECgene alternative splicing isoforms for MESDC2

    Expression
    for MESDC2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MESDC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAGGTTCTCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MESDC2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Head MesenchymeBranchial Arch 1Cranial Neural Crest CellsNeural Crest
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MESDC2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MESDC2

    SOURCE GeneReport for Unigene clusters: Hs.578450 Hs.732380
        SABiosciences Custom PCR Arrays for MESDC2
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    In Situ
    Assay Products:     
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    Orthologs
    for MESDC2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MESDC2 gene from 7/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Mesdc21 , 5 mesoderm development candidate 21, 5 84.82(n)1
    87.5(a)1    		   7 (48.35 cM)5
    679431  NM_023403.31  NP_075892.31 
     838844665 
    chicken
    (Gallus gallus)    		 Aves MESDC21 mesoderm development candidate 2 72.79(n)
    78.74(a)    		   415475  NM_001030551.1  NP_001025722.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MESDC26
    		 --
    		 72(a)
    		 1 ↔ 1
    		 GL343332.1(825974-831530)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.257322 Xenopus laevis transcribed sequence with weak similarity more 82.42(n)    BJ625696.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii mesdc21 mesoderm development candidate 2 69.25(n)
    72.9(a)    		   791222  NM_001080704.1  NP_001074173.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta boca1 CG30498-PA 58.62(n)
    51.72(a)    		   48986  NM_165541.1  NP_724578.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea bmy-11 Protein BMY-1 50.12(n)
    44.06(a)    		   173908  NM_062602.2  NP_495003.2 


    ENSEMBL Gene Tree for MESDC2 (if available)
    TreeFam Gene Tree for MESDC2 (if available) 

    Paralogs
    for MESDC2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MESDC2 gene

    MESDC2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MESDC2
    PGOHUM00000239756


    Genomic Variants
    for MESDC2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/328 NCBI SNPs in MESDC2 are shown (see all 328)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1393838641,2
    		--81267623(+) CGGGAC/GGCTGA 1 -- ds50010--------
    rs1441655401,2
    		--81267630(+) CTGAGA/GCAAGA 1 -- ds50010--------
    rs1871817921,2
    		--81267672(+) AGTGAA/GCTATG 1 -- ds50010--------
    rs1924829881,2
    		--81267697(+) CTCTAG/TCCTGA 1 -- ds50010--------
    rs1464820981,2
    		--81267734(+) TAAAAA/GACAAA 1 -- ds50010--------
    rs351391991,2
    		C,--81267924(+) TTTCCC/ATTGTT 1 -- ds50012Minor allele frequency- A:0.05NA 122
    rs1399412191,2
    		--81268057(+) TGAAGA/GAGGAA 1 -- ds50010--------
    rs1442906071,2
    		--81268115(+) TCATCC/TAAATT 1 -- ut310--------
    rs1452232191,2
    		--81268272(+) CTGCAC/TTCTAG 1 -- ut310--------
    rs71825491,2
    		C,F,H,--81268287(+) ggcaaC/Aagagt 1 -- ut3114Minor allele frequency- A:0.08NS EA NA WA 1878

    HapMap Linkage Disequilibrium report for MESDC2 (81239667 - 81282219 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MESDC2: --
    Human Gene Mutation Database (HGMD): MESDC2

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MESDC2
    DNA2.0 Custom Variant and Variant Library Synthesis for MESDC2

    Disorders / Diseases
    for MESDC2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MESDC2 for disorders           About GeneDecksing

    OMIM gene information: 607783    OMIM disorders: --

    9 diseases for MESDC2:    About MalaCards
    renal carcinoma    dental pulp necrosis    pyoderma gangrenosum    oculocutaneous albinism
    carcinoma    albinism    pyoderma    renal cell carcinoma
    teratoma


    Export disorders for MESDC2 gene to outside databases

    Publications
    for MESDC2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MESDC2 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with MESDC2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7788527)1, 2, 3 Nagase T....Kotani H. (1995)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    5. Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis. (PubMed id 11247670)1, 3 Wines M.E.... Holdener B.C. (2001)
    6. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (1999)
    7. Fusion of the SUMO/Sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a patient with an infantile teratoma and a constitutional t(12;15)(q13;q25). (PubMed id 15917269)1, 9 Veltman I.M....van Kessel A.G. (2005)
    8. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. MESD is essential for apical localization of megalin/ LRP2 in the visceral endoderm. (PubMed id 21337463)1 Lighthouse J.K....Holdener B.C. (2011)

    External Searches for MESDC2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing MESDC2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23184 HGNC: 13520 AceView: MESDC2 Ensembl:ENSG00000117899 euGenes: HUgn23184
    ECgene: MESDC2 H-InvDB: MESDC2

    Other Databases showing MESDC2 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0081

    Specialized Databases showing MESDC2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MESDC2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MESDC2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MESDC2 gene:
    Search GeneIP for patents involving MESDC2

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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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