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Aliases for MESDC2 Gene

Aliases for MESDC2 Gene

  • Mesoderm Development Candidate 2 2 3 4 5
  • Renal Carcinoma Antigen NY-REN-61 3 4
  • Mesoderm Development Protein 3 4
  • MESD 3 4
  • LDLR Chaperone MESD 3
  • KIAA0081 4
  • BOCA 3

External Ids for MESDC2 Gene

Previous GeneCards Identifiers for MESDC2 Gene

  • GC15M077196
  • GC15M074396
  • GC15M078815
  • GC15M078955
  • GC15M078983
  • GC15M079026
  • GC15M081244
  • GC15M058026

Summaries for MESDC2 Gene

GeneCards Summary for MESDC2 Gene

MESDC2 (Mesoderm Development Candidate 2) is a Protein Coding gene. Among its related pathways are Wnt / Hedgehog / Notch. GO annotations related to this gene include low-density lipoprotein particle receptor binding.

UniProtKB/Swiss-Prot for MESDC2 Gene

  • Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.

Gene Wiki entry for MESDC2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MESDC2 Gene

Genomics for MESDC2 Gene

Regulatory Elements for MESDC2 Gene

Enhancers for MESDC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F081029 0.8 FANTOM5 Ensembl 22.1 -40.1 -40123 2.0 CBX3 JUN BACH1 ZIC2 ZNF316 STAT2 TRIM24 FOS NFE2 MAFK MESDC1 MESDC2 STARD5 GC15M081029 GC15P081022
GH15F080984 1.2 FANTOM5 ENCODE 19.3 +4.7 4733 1.9 CBX3 ZFP64 ZNF140 ZNF101 ZNF664 NCOR1 ZSCAN29 ZNF600 ZNF202 ZNF280D ENSG00000259649 MESDC2 MESDC1 STARD5 GC15M080955
GH15F080934 0.8 Ensembl ENCODE 17.4 +55.0 55015 1.1 ZFHX2 JUN PRDM1 EGR2 MESDC2 MESDC1 GC15M080926 GC15P080943
GH15F080999 0.5 ENCODE 12.7 -11.5 -11545 4.2 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZNF143 KLF13 MESDC2 MESDC1 GC15M081000 PIR45812
GH15F080988 0.7 ENCODE 12.5 -0.2 -226 4.2 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 MESDC2 MESDC1 ENSG00000260619
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MESDC2 on UCSC Golden Path with GeneCards custom track

Promoters for MESDC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000238587 478 2001 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207

Genomic Location for MESDC2 Gene

Chromosome:
15
Start:
80,946,289 bp from pter
End:
80,989,878 bp from pter
Size:
43,590 bases
Orientation:
Minus strand

Genomic View for MESDC2 Gene

Genes around MESDC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MESDC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MESDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MESDC2 Gene

Proteins for MESDC2 Gene

  • Protein details for MESDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14696-MESD_HUMAN
    Recommended name:
    LDLR chaperone MESD
    Protein Accession:
    Q14696
    Secondary Accessions:
    • B4DW84
    • D3DW96
    • Q969U1

    Protein attributes for MESDC2 Gene

    Size:
    234 amino acids
    Molecular mass:
    26077 Da
    Quaternary structure:
    • Monomer (By similarity). Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP6; the interaction prevents LRP6 from forming aggregates and chaperones LRP6 to the plasma membrane.
    SequenceCaution:
    • Sequence=BAA07640.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MESDC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MESDC2 Gene

Post-translational modifications for MESDC2 Gene

  • Glycosylation at Ser 88 and Asn 201
  • Modification sites at PhosphoSitePlus

Other Protein References for MESDC2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MESDC2 (MESDC2)
  • Abcam antibodies for MESDC2

No data available for DME Specific Peptides for MESDC2 Gene

Domains & Families for MESDC2 Gene

Protein Domains for MESDC2 Gene

Suggested Antigen Peptide Sequences for MESDC2 Gene

Graphical View of Domain Structure for InterPro Entry

Q14696

UniProtKB/Swiss-Prot:

MESD_HUMAN :
  • The chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of LRP5/6.
  • Belongs to the MESD family.
Domain:
  • The chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of LRP5/6.
  • The escort domain ensures LRP5/6 safe-trafficking from the ER to the Golgi by preventing premature ligand-binding.
Family:
  • Belongs to the MESD family.
genes like me logo Genes that share domains with MESDC2: view

No data available for Gene Families for MESDC2 Gene

Function for MESDC2 Gene

Molecular function for MESDC2 Gene

UniProtKB/Swiss-Prot Function:
Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.

Gene Ontology (GO) - Molecular Function for MESDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0050750 low-density lipoprotein particle receptor binding IEA --
genes like me logo Genes that share ontologies with MESDC2: view
genes like me logo Genes that share phenotypes with MESDC2: view

Animal Models for MESDC2 Gene

MGI Knock Outs for MESDC2:

Animal Model Products

  • Taconic Biosciences Mouse Models for MESDC2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MESDC2 Gene

Localization for MESDC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MESDC2 Gene

Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MESDC2 Gene COMPARTMENTS Subcellular localization image for MESDC2 gene
Compartment Confidence
endoplasmic reticulum 4
extracellular 3
cytosol 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for MESDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005783 endoplasmic reticulum IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with MESDC2: view

Pathways & Interactions for MESDC2 Gene

SuperPathways for MESDC2 Gene

SuperPathway Contained pathways
1 Wnt / Hedgehog / Notch
genes like me logo Genes that share pathways with MESDC2: view

Pathways by source for MESDC2 Gene

1 Cell Signaling Technology pathway for MESDC2 Gene

Gene Ontology (GO) - Biological Process for MESDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding ISS --
GO:0007498 mesoderm development NAS 11247670
GO:0016055 Wnt signaling pathway IEA --
GO:0034394 protein localization to cell surface IEA --
genes like me logo Genes that share ontologies with MESDC2: view

No data available for SIGNOR curated interactions for MESDC2 Gene

Transcripts for MESDC2 Gene

Unigene Clusters for MESDC2 Gene

Mesoderm development candidate 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MESDC2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1:
SP2:
SP3: -

Relevant External Links for MESDC2 Gene

GeneLoc Exon Structure for
MESDC2
ECgene alternative splicing isoforms for
MESDC2

Expression for MESDC2 Gene

mRNA expression in normal human tissues for MESDC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MESDC2 Gene



Protein tissue co-expression partners for MESDC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MESDC2 Gene:

MESDC2

SOURCE GeneReport for Unigene cluster for MESDC2 Gene:

Hs.578450
genes like me logo Genes that share expression patterns with MESDC2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MESDC2 Gene

Orthologs for MESDC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MESDC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MESDC2 34 35
  • 99.86 (n)
dog
(Canis familiaris)
Mammalia MESDC2 34 35
  • 86.3 (n)
cow
(Bos Taurus)
Mammalia MESDC2 34 35
  • 84.91 (n)
mouse
(Mus musculus)
Mammalia Mesdc2 34 16 35
  • 82.59 (n)
rat
(Rattus norvegicus)
Mammalia Mesdc2 34
  • 82.14 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 77 (a)
OneToMany
-- 35
  • 60 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia MESDC2 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves MESDC2 34 35
  • 71.47 (n)
lizard
(Anolis carolinensis)
Reptilia MESDC2 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mesdc2 34
  • 71.15 (n)
Str.15051 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.25732 34
zebrafish
(Danio rerio)
Actinopterygii mesdc2 34 35
  • 75.41 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.948 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005081 34
  • 58.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta boca 34 35
  • 57.24 (n)
worm
(Caenorhabditis elegans)
Secernentea bmy-1 34 35
  • 49.31 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 51 (a)
OneToOne
Species where no ortholog for MESDC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MESDC2 Gene

ENSEMBL:
Gene Tree for MESDC2 (if available)
TreeFam:
Gene Tree for MESDC2 (if available)

Paralogs for MESDC2 Gene

Pseudogenes.org Pseudogenes for MESDC2 Gene

genes like me logo Genes that share paralogs with MESDC2: view

No data available for Paralogs for MESDC2 Gene

Variants for MESDC2 Gene

Sequence variations from dbSNP and Humsavar for MESDC2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1012540 -- 80,953,751(-) CCTCC(A/T)GTCTG intron-variant
rs1012541 -- 80,953,687(-) GCCTT(C/T)CCAGC intron-variant
rs10152657 -- 80,956,735(+) AAACC(C/T)GGGAT intron-variant
rs1048000 -- 80,951,533(+) ATGTA(C/T)AGAGT intron-variant, utr-variant-3-prime
rs1050524 -- 80,979,113(-) ACATT(C/G/T)TAGTG intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MESDC2 Gene

Variant ID Type Subtype PubMed ID
nsv1071224 CNV deletion 25765185

Variation tolerance for MESDC2 Gene

Residual Variation Intolerance Score: 53.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.58; 30.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MESDC2 Gene

Human Gene Mutation Database (HGMD)
MESDC2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MESDC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MESDC2 Gene

Disorders for MESDC2 Gene

Relevant External Links for MESDC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MESDC2

No disorders were found for MESDC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MESDC2 Gene

Publications for MESDC2 Gene

  1. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7788527) Nagase T. … Nomura N. (DNA Res. 1995) 2 3 4 64
  2. Fusion of the SUMO/Sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a patient with an infantile teratoma and a constitutional t(12;15)(q13;q25). (PMID: 15917269) Veltman I.M. … van Kessel A.G. (Hum. Mol. Genet. 2005) 3 22 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4 64

Products for MESDC2 Gene

Sources for MESDC2 Gene

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