MESDC1 Gene
protein-coding GIFtS: 40
GCID: GC15P081293
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mesoderm development candidate 1
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Aliases
for MESDC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mesoderm Development Candidate 11 2 | | MGC995951 |
Export aliases for MESDC1 gene to outside databasesPrevious GC identifers: GC15P077250 GC15P074451 GC15P078869 GC15P079009 GC15P079081 GC15P058051 |
Summaries
for MESDC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for MESDC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MESDC1 gene promoter:
Pax-5 SREBP-1c SREBP-1b CREB E2F SREBP-1a deltaCREB FOXJ2 (long isoform) FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for MESDC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MESDC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q13 Ensembl cytogenetic band: 15q25.1 HGNC cytogenetic band: 15q13MESDC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P081293: view genomic region
(about GC identifiers)
Start:
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81,293,295 bp from pter |
End:
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81,296,345 bp from pter |
Size:
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3,051 bases |
Orientation:
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plus strand |
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Proteins
for MESDC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MESD1_HUMAN, Q9H1K6 (See
protein sequence)Recommended Name: Mesoderm development candidate 1 Size: 362 amino acids; 37758 DaExplore the universe of human proteins at neXtProt for MESDC1: NX_Q9H1K6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H1K6
MESDC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_072088.1
ENSEMBL proteins: ENSP00000267984
Human Recombinant Protein Products:
MESDC1 Antibody Products:
Assay Products for MESDC1: |
Protein
Domains /
Families
for MESDC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9H1K6 |
Function
for MESDC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MESDC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MESDC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MESDC1 (NM_022566) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MESDC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MESDC1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MESDC1 |
3 GenomeRNAi human phenotypes for MESDC1:
|
Pathways & Interactions
for MESDC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MESDC1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for MESDC1 (Q9H1K63 ENSP000002679844) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for MESDC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MESDC1
Search CenterWatch for drugs/clinical trials and news about MESDC1 / MESD1
|
Transcripts
for MESDC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MESDC1 gene: NM_022566.2 Unigene Cluster for MESDC1: Mesoderm development candidate 1 Hs.513071 [show with all ESTs]Unigene Representative Sequence: NM_0225661 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000267984(uc002bfz.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MESDC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MESDC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MESDC1 (NM_022566) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MESDC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MESDC1 |
Additional cDNA sequence: AY007810.1 BC001373.2 BC084554.1 6 DOTS entries: DT.212169 DT.99982855 DT.100036331 DT.100813261 DT.97763492 DT.95182490 1 AceView cDNA sequence: AW136099
GeneLoc Exon Structure
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Expression
for MESDC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MESDC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACTGGAGTA
About this image
See MESDC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MESDC1
SOURCE GeneReport for Unigene cluster: Hs.513071
SABiosciences Custom PCR Arrays for MESDC1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MESDC1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MESDC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MESDC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MESDC1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MESDC1 |
Orthologs
for MESDC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MESDC1 gene from 5/17 species (see all 17) About this table
ENSEMBL Gene Tree for MESDC1 (if available)
TreeFam Gene Tree for MESDC1 (if available) |
Paralogs
for MESDC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MESDC1 gene
- TLN22 HIP12 HIP1R2 TLN12
MESDC1 for paralogs About GeneDecksing
|
Genomic Variants
for MESDC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MESDC1 (81293295 - 81296345 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MESDC1
1 CNV: 72302 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MESDC1 |
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Disorders
/ Diseases
for MESDC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MESDC1 for disorders About GeneDecksing
2  diseases for MESDC1: About MalaCardspyoderma gangrenosum pyoderma
1 disease from the University of Copenhagen DISEASES database for MESDC1:Pyoderma gangrenosum Export disorders for MESDC1 gene to outside databases
|
Publications
for MESDC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MESDC1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MESDC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis. (PubMed id 11247670)1, 2, 3 Wines M.E.... Holdener B.C. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Novel oncogenic function of mesoderm development candi date 1 and its regulation by MiR-574-3p in bladder cancer cell lines. (PubMed id 22179486)1 Tatarano S....Nakagawa M. (2012)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Modulation of LRP6-mediated Wnt signaling by molecular chaperone Mesd. (PubMed id 16989816)1 Li Y....Bu G. (2006)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for MESDC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing MESDC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MESDC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MESDC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MESDC1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for MESDC1 gene:
Search GeneIP for patents involving MESDC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MESDC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MESDC1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MESDC1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MESDC1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MESDC1 | | OriGene 3'-UTR Clone for MESDC1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MESDC1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MESDC1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MESDC1 | | OriGene Custom Protein Services for MESDC1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MESDC1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MESDC1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MESDC1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MESDC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MESDC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MESDC1 |
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| | | | Search Tocris compounds for MESDC1 |
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 | | | MESDC1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MESDC1 |
|  |  |  | | | | Search ThermoFisher Antibodies for MESDC1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MESDC1 |
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