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Aliases for MESDC1 Gene

Aliases for MESDC1 Gene

  • Mesoderm Development Candidate 1 2 3 5

External Ids for MESDC1 Gene

Previous GeneCards Identifiers for MESDC1 Gene

  • GC15P077250
  • GC15P074451
  • GC15P078869
  • GC15P079009
  • GC15P079081
  • GC15P081293
  • GC15P058051

Summaries for MESDC1 Gene

GeneCards Summary for MESDC1 Gene

MESDC1 (Mesoderm Development Candidate 1) is a Protein Coding gene. An important paralog of this gene is MIR6852.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MESDC1 Gene

Genomics for MESDC1 Gene

Regulatory Elements for MESDC1 Gene

Enhancers for MESDC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MESDC1 on UCSC Golden Path with GeneCards custom track

Promoters for MESDC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MESDC1 Gene

81,000,944 bp from pter
81,005,788 bp from pter
4,845 bases
Plus strand

Genomic View for MESDC1 Gene

Genes around MESDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MESDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MESDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MESDC1 Gene

Proteins for MESDC1 Gene

  • Protein details for MESDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mesoderm development candidate 1
    Protein Accession:

    Protein attributes for MESDC1 Gene

    362 amino acids
    Molecular mass:
    37758 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MESDC1 Gene

Post-translational modifications for MESDC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MESDC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MESDC1 Gene

Domains & Families for MESDC1 Gene

Protein Domains for MESDC1 Gene


Suggested Antigen Peptide Sequences for MESDC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MESDC1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for MESDC1 Gene

Function for MESDC1 Gene

genes like me logo Genes that share phenotypes with MESDC1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MESDC1 Gene

Localization for MESDC1 Gene

Subcellular locations from

Jensen Localization Image for MESDC1 Gene COMPARTMENTS Subcellular localization image for MESDC1 gene
Compartment Confidence
cytosol 1
extracellular 1
mitochondrion 1
nucleus 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MESDC1 Gene

Pathways & Interactions for MESDC1 Gene

SuperPathways for MESDC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MESDC1 Gene


No data available for Pathways by source and SIGNOR curated interactions for MESDC1 Gene

Drugs & Compounds for MESDC1 Gene

No Compound Related Data Available

Transcripts for MESDC1 Gene

mRNA/cDNA for MESDC1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MESDC1 Gene

Mesoderm development candidate 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MESDC1 Gene

No ASD Table

Relevant External Links for MESDC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MESDC1 Gene

mRNA expression in normal human tissues for MESDC1 Gene

Protein differential expression in normal tissues from HIPED for MESDC1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (26.2), Amniocyte (20.9), Bone marrow stromal cell (6.6), and Neutrophil (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MESDC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MESDC1 Gene:


SOURCE GeneReport for Unigene cluster for MESDC1 Gene:

genes like me logo Genes that share expression patterns with MESDC1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MESDC1 Gene

Orthologs for MESDC1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MESDC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MESDC1 34
  • 95.03 (n)
  • 98.34 (a)
  • 98 (a)
(Canis familiaris)
Mammalia MESDC1 34
  • 96.04 (n)
  • 97.79 (a)
  • 98 (a)
(Mus musculus)
Mammalia Mesdc1 34
  • 90.88 (n)
  • 98.07 (a)
Mesdc1 16
Mesdc1 35
  • 98 (a)
(Pan troglodytes)
Mammalia MESDC1 34
  • 99.54 (n)
  • 99.72 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Mesdc1 34
  • 91.16 (n)
  • 98.07 (a)
(Monodelphis domestica)
Mammalia MESDC1 35
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia MESDC1 35
  • 87 (a)
(Gallus gallus)
Aves MESDC1 34
  • 75.31 (n)
  • 79.72 (a)
  • 79 (a)
(Anolis carolinensis)
Reptilia MESDC1 35
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mesdc1 34
  • 77.68 (n)
  • 78.57 (a)
MGC75847 34
(Danio rerio)
Actinopterygii LOC100003148 34
  • 70.35 (n)
  • 72.52 (a)
  • 72 (a)
(Caenorhabditis elegans)
Secernentea Y18D10A.22 35
  • 5 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLA2 35
  • 7 (a)
Species where no ortholog for MESDC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MESDC1 Gene

Gene Tree for MESDC1 (if available)
Gene Tree for MESDC1 (if available)

Paralogs for MESDC1 Gene

Paralogs for MESDC1 Gene

genes like me logo Genes that share paralogs with MESDC1: view

Variants for MESDC1 Gene

Sequence variations from dbSNP and Humsavar for MESDC1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs3803362 -- 80,999,679(+) GTCAT(A/C)CTAGT upstream-variant-2KB
rs11541231 -- 81,002,433(+) CTGTC(C/G/T)AGCGA reference, synonymous-codon
rs56209748 -- 81,000,523(+) GCCGA(A/T)ATCCA upstream-variant-2KB
rs56246246 -- 81,000,421(+) TCGTG(A/G)AAGTG upstream-variant-2KB
rs56923532 -- 81,000,311(+) AAGGC(A/G)TATTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MESDC1 Gene

Variant ID Type Subtype PubMed ID
esv28677 CNV loss 19812545
nsv1143787 CNV deletion 24896259
nsv1637 CNV deletion 18451855

Variation tolerance for MESDC1 Gene

Residual Variation Intolerance Score: 33.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.57; 30.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MESDC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MESDC1 Gene

Disorders for MESDC1 Gene

Relevant External Links for MESDC1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MESDC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MESDC1 Gene

Publications for MESDC1 Gene

  1. Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis. (PMID: 11247670) Wines M.E. … Holdener B.C. (Genomics 2001) 2 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. Novel oncogenic function of mesoderm development candidate 1 and its regulation by MiR-574-3p in bladder cancer cell lines. (PMID: 22179486) Tatarano S. … Nakagawa M. (Int. J. Oncol. 2012) 3 65
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 65
  5. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S. … Mohammed S. (Anal. Chem. 2009) 4 65

Products for MESDC1 Gene

Sources for MESDC1 Gene

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