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Aliases for MESDC1 Gene

Aliases for MESDC1 Gene

  • Mesoderm Development Candidate 1 2 3

External Ids for MESDC1 Gene

Previous GeneCards Identifiers for MESDC1 Gene

  • GC15P077250
  • GC15P074451
  • GC15P078869
  • GC15P079009
  • GC15P079081
  • GC15P081293
  • GC15P058051

Summaries for MESDC1 Gene

GeneCards Summary for MESDC1 Gene

MESDC1 (Mesoderm Development Candidate 1) is a Protein Coding gene. An important paralog of this gene is HIP1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MESDC1 Gene

Genomics for MESDC1 Gene

Regulatory Elements for MESDC1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MESDC1 Gene

81,000,944 bp from pter
81,005,788 bp from pter
4,845 bases
Plus strand

Genomic View for MESDC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MESDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MESDC1 Gene

Proteins for MESDC1 Gene

  • Protein details for MESDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mesoderm development candidate 1
    Protein Accession:
    Secondary Accessions:

    Protein attributes for MESDC1 Gene

    362 amino acids
    Molecular mass:
    37758 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MESDC1 Gene

Proteomics data for MESDC1 Gene at MOPED

Post-translational modifications for MESDC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MESDC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MESDC1 Gene

Domains for MESDC1 Gene

Protein Domains for MESDC1 Gene


Suggested Antigen Peptide Sequences for MESDC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MESDC1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for MESDC1 Gene

Function for MESDC1 Gene

Gene Ontology (GO) - Molecular Function for MESDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with MESDC1: view

Phenotypes for MESDC1 Gene

genes like me logo Genes that share phenotypes with MESDC1: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MESDC1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MESDC1 Gene

Localization for MESDC1 Gene

Subcellular locations from

Jensen Localization Image for MESDC1 Gene COMPARTMENTS Subcellular localization image for MESDC1 gene
Compartment Confidence
cytosol 1
extracellular 1
mitochondrion 1
nucleus 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MESDC1 Gene

Pathways for MESDC1 Gene

SuperPathways for MESDC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MESDC1 Gene


No data available for Pathways by source for MESDC1 Gene

Transcripts for MESDC1 Gene

mRNA/cDNA for MESDC1 Gene

(3) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MESDC1 Gene

Mesoderm development candidate 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MESDC1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MESDC1 Gene

No ASD Table

Relevant External Links for MESDC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MESDC1 Gene

mRNA expression in normal human tissues for MESDC1 Gene

Protein differential expression in normal tissues for MESDC1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (26.2), Amniocyte (20.9), Bone marrow stromal cell (6.6), and Neutrophil (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MESDC1 Gene

SOURCE GeneReport for Unigene cluster for MESDC1 Gene Hs.513071

genes like me logo Genes that share expressions with MESDC1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for MESDC1 Gene

Orthologs for MESDC1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MESDC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MESDC1 35
  • 95.03 (n)
  • 98.34 (a)
  • 98 (a)
(Canis familiaris)
Mammalia MESDC1 35
  • 96.04 (n)
  • 97.79 (a)
  • 98 (a)
(Mus musculus)
Mammalia Mesdc1 35
  • 90.88 (n)
  • 98.07 (a)
Mesdc1 16
Mesdc1 36
  • 98 (a)
(Pan troglodytes)
Mammalia MESDC1 35
  • 99.54 (n)
  • 99.72 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Mesdc1 35
  • 91.16 (n)
  • 98.07 (a)
(Monodelphis domestica)
Mammalia MESDC1 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia MESDC1 36
  • 87 (a)
(Gallus gallus)
Aves MESDC1 35
  • 75.31 (n)
  • 79.72 (a)
  • 79 (a)
(Anolis carolinensis)
Reptilia MESDC1 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mesdc1 35
  • 77.68 (n)
  • 78.57 (a)
MGC75847 35
(Danio rerio)
Actinopterygii LOC100003148 35
  • 70.35 (n)
  • 72.52 (a)
  • 72 (a)
(Caenorhabditis elegans)
Secernentea Y18D10A.22 36
  • 5 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLA2 36
  • 7 (a)
Species with no ortholog for MESDC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MESDC1 Gene

Gene Tree for MESDC1 (if available)
Gene Tree for MESDC1 (if available)

Paralogs for MESDC1 Gene

Paralogs for MESDC1 Gene

genes like me logo Genes that share paralogs with MESDC1: view

Variants for MESDC1 Gene

Sequence variations from dbSNP and Humsavar for MESDC1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1063866 -- 81,003,930(+) TTTTT(C/T)CCCCC utr-variant-3-prime
rs3803362 -- 80,999,679(+) GTCAT(A/C)CTAGT upstream-variant-2KB
rs7169370 -- 81,003,664(+) AATTT(C/G)ATTAT utr-variant-3-prime
rs10162726 -- 80,999,804(+) TAGAG(A/G)ACCTG upstream-variant-2KB
rs10162741 -- 80,999,784(+) CTGTG(G/T)TGGGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MESDC1 Gene

Variant ID Type Subtype PubMed ID
nsv1637 CNV Loss 18451855
esv28677 CNV Loss 19812545

Relevant External Links for MESDC1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MESDC1 Gene

Disorders for MESDC1 Gene

(1) University of Copenhagen DISEASES for MESDC1 Gene

Relevant External Links for MESDC1

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with MESDC1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for MESDC1 Gene

Publications for MESDC1 Gene

  1. Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis. (PMID: 11247670) Wines M.E. … Holdener B.C. (Genomics 2001) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Modulation of LRP6-mediated Wnt signaling by molecular chaperone Mesd. (PMID: 16989816) Li Y. … Bu G. (FEBS Lett. 2006) 3
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. Novel oncogenic function of mesoderm development candidate 1 and its regulation by MiR-574-3p in bladder cancer cell lines. (PMID: 22179486) Tatarano S. … Nakagawa M. (Int. J. Oncol. 2012) 3

Products for MESDC1 Gene

Sources for MESDC1 Gene

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