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Aliases for MEPE Gene

Aliases for MEPE Gene

  • Matrix Extracellular Phosphoglycoprotein 2 3
  • Matrix, Extracellular Phosphoglycoprotein With ASARM Motif (Bone) 2 3
  • Osteoblast/Osteocyte Factor 45 3 4
  • OF45 3 4

External Ids for MEPE Gene

Previous GeneCards Identifiers for MEPE Gene

  • GC04P088911
  • GC04P089055
  • GC04P089212
  • GC04P089191
  • GC04P089099
  • GC04P088961
  • GC04P088754
  • GC04P084488

Summaries for MEPE Gene

Entrez Gene Summary for MEPE Gene

  • This gene encodes a secreted calcium-binding phosphoprotein that belongs to the small integrin-binding ligand, N-linked glycoprotein (SIBLING) family of proteins. Members of this family are components of the extracellular matrix of bone and dentin and regulate bone mineralization. Deficiency of a similar protein in mouse results in increased bone mass. Mice lacking this gene are resistant to aging-related trabecular bone loss. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for MEPE Gene

MEPE (Matrix Extracellular Phosphoglycoprotein) is a Protein Coding gene. Diseases associated with MEPE include hypophosphatemic rickets, autosomal dominant and oncogenic osteomalacia. Among its related pathways are Phospholipase-C Pathway and ERK Signaling. GO annotations related to this gene include extracellular matrix structural constituent.

UniProtKB/Swiss-Prot for MEPE Gene

  • Promotes renal phosphate excretion and modulates mineralization.

Gene Wiki entry for MEPE Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEPE Gene

Genomics for MEPE Gene

Regulatory Elements for MEPE Gene

Genomic Location for MEPE Gene

Chromosome:
4
Start:
87,821,398 bp from pter
End:
87,846,817 bp from pter
Size:
25,420 bases
Orientation:
Plus strand

Genomic View for MEPE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MEPE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEPE Gene

Proteins for MEPE Gene

  • Protein details for MEPE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQ76-MEPE_HUMAN
    Recommended name:
    Matrix extracellular phosphoglycoprotein
    Protein Accession:
    Q9NQ76
    Secondary Accessions:
    • A1A4X9
    • A8MTA3
    • D2CFR4
    • F5H5C5

    Protein attributes for MEPE Gene

    Size:
    525 amino acids
    Molecular mass:
    58419 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MEPE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEPE Gene

Proteomics data for MEPE Gene at MOPED

Post-translational modifications for MEPE Gene

  • Phosphorylated (in vitro) by FAM20C in the extracellular medium at sites within the S-x-E/pS motif.
  • Glycosylation at Asn 477 and Asn 478
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for MEPE Gene

Domains & Families for MEPE Gene

Protein Domains for MEPE Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MEPE: view

No data available for Gene Families and UniProtKB/Swiss-Prot for MEPE Gene

Function for MEPE Gene

Molecular function for MEPE Gene

UniProtKB/Swiss-Prot Function:
Promotes renal phosphate excretion and modulates mineralization.

Gene Ontology (GO) - Molecular Function for MEPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005201 extracellular matrix structural constituent TAS 10945470
GO:0005515 protein binding IPI 17474147
GO:1990430 extracellular matrix protein binding IBA --
genes like me logo Genes that share ontologies with MEPE: view
genes like me logo Genes that share phenotypes with MEPE: view

Animal Models for MEPE Gene

MGI Knock Outs for MEPE:

Animal Model Products

miRNA for MEPE Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MEPE

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for MEPE Gene

Localization for MEPE Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEPE Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MEPE Gene COMPARTMENTS Subcellular localization image for MEPE gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for MEPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
genes like me logo Genes that share ontologies with MEPE: view

Pathways & Interactions for MEPE Gene

genes like me logo Genes that share pathways with MEPE: view

Pathways by source for MEPE Gene

Gene Ontology (GO) - Biological Process for MEPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 10945470
GO:0030502 negative regulation of bone mineralization IEA --
GO:0031214 biomineral tissue development IBA --
genes like me logo Genes that share ontologies with MEPE: view

No data available for SIGNOR curated interactions for MEPE Gene

Drugs & Compounds for MEPE Gene

(1) Drugs for MEPE Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcitriol Approved Nutra TNF-α and IL-1β production inhibitor, Vitamin D receptor (VDR) agonist 158
genes like me logo Genes that share compounds with MEPE: view

Transcripts for MEPE Gene

mRNA/cDNA for MEPE Gene

(7) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MEPE Gene

Matrix extracellular phosphoglycoprotein:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MEPE

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEPE Gene

No ASD Table

Relevant External Links for MEPE Gene

GeneLoc Exon Structure for
MEPE
ECgene alternative splicing isoforms for
MEPE

Expression for MEPE Gene

mRNA expression in normal human tissues for MEPE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEPE Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x14.3), Brain - Frontal Cortex (BA9) (x11.7), Brain - Cortex (x8.4), Brain - Amygdala (x6.0), and Brain - Hippocampus (x5.7).

Protein differential expression in normal tissues from HIPED for MEPE Gene

This gene is overexpressed in Fetal ovary (50.7) and Testis (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MEPE Gene



SOURCE GeneReport for Unigene cluster for MEPE Gene Hs.676357

mRNA Expression by UniProt/SwissProt for MEPE Gene

Q9NQ76-MEPE_HUMAN
Tissue specificity: Expressed by osteoblasts. Secreted from oncogenic hypophosphataemic tumors
genes like me logo Genes that share expression patterns with MEPE: view

Protein tissue co-expression partners for MEPE Gene

Primer Products

In Situ Assay Products

Orthologs for MEPE Gene

This gene was present in the common ancestor of mammals.

Orthologs for MEPE Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MEPE 35
  • 78.92 (n)
  • 65.86 (a)
MEPE 36
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MEPE 35
  • 83.1 (n)
  • 71.52 (a)
mouse
(Mus musculus)
Mammalia Mepe 35
  • 67.81 (n)
  • 52.12 (a)
Mepe 16
Mepe 36
  • 51 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MEPE 35
  • 99.2 (n)
  • 98.2 (a)
MEPE 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mepe 35
  • 67.93 (n)
  • 50.54 (a)
oppossum
(Monodelphis domestica)
Mammalia MEPE 36
  • 35 (a)
OneToOne
Species with no ortholog for MEPE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MEPE Gene

ENSEMBL:
Gene Tree for MEPE (if available)
TreeFam:
Gene Tree for MEPE (if available)

Paralogs for MEPE Gene

No data available for Paralogs for MEPE Gene

Variants for MEPE Gene

Sequence variations from dbSNP and Humsavar for MEPE Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_034094 -

Structural Variations from Database of Genomic Variants (DGV) for MEPE Gene

Variant ID Type Subtype PubMed ID
nsv822637 CNV Gain 20364138
dgv94n17 CNV Loss 16327808
esv275333 CNV Gain+Loss 21479260

Variation tolerance for MEPE Gene

Residual Variation Intolerance Score: 89.42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.16; 51.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MEPE Gene

HapMap Linkage Disequilibrium report
MEPE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEPE Gene

Disorders for MEPE Gene

MalaCards: The human disease database

(5) MalaCards diseases for MEPE Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
hypophosphatemic rickets, autosomal dominant
  • autosomal dominant hypophosphatemic rickets
oncogenic osteomalacia
  • oo
hypophosphatemia
tumoral calcinosis
  • calcinosis, tumoral
osteoporosis
  • osteoporosis, postmenopausal, susceptibility
- elite association
Search MEPE in MalaCards View complete list of genes associated with diseases

Relevant External Links for MEPE

Genetic Association Database (GAD)
MEPE
Human Genome Epidemiology (HuGE) Navigator
MEPE
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MEPE
genes like me logo Genes that share disorders with MEPE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MEPE Gene

Publications for MEPE Gene

  1. MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia. (PMID: 10945470) Rowe P.S.N. … Oudet C.L. (Genomics 2000) 2 23 67
  2. Regulation of phosphate transport by fibroblast growth factor 23 (FGF23): implications for disorders of phosphate metabolism. (PMID: 19669798) Gattineni J. … Baum M. (Pediatr. Nephrol. 2010) 23 67
  3. MEPE evolution in mammals reveals regions and residues of prime functional importance. (PMID: 19924383) Bardet C. … Sire J.Y. (Cell. Mol. Life Sci. 2010) 23 67
  4. FGF-23 in bone biology. (PMID: 20012997) Wesseling-Perry K. (Pediatr. Nephrol. 2010) 23 67
  5. Phosphorylation-dependent inhibition of mineralization by osteopontin ASARM peptides is regulated by PHEX cleavage. (PMID: 19775205) Addison W.N. … McKee M.D. (J. Bone Miner. Res. 2010) 23 67

Products for MEPE Gene

Sources for MEPE Gene

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