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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MEPE Gene

protein-coding   GIFtS: 53
GCID: GC04P088754

Matrix Extracellular Phosphoglycoprotein

(Previous names: matrix, extracellular phosphoglycoprotein with ASARM motif...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Matrix Extracellular Phosphoglycoprotein1 2
Matrix, Extracellular Phosphoglycoprotein With ASARM Motif (Bone)1 2
Osteoblast/Osteocyte Factor 452 3
OF452 3

External Ids:    HGNC: 133611   Entrez Gene: 569552   Ensembl: ENSG000001525957   OMIM: 6059125   UniProtKB: Q9NQ763   

Export aliases for MEPE gene to outside databases

Previous GC identifers: GC04P088911 GC04P089055 GC04P089212 GC04P089191 GC04P089099 GC04P088961 GC04P084488


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MEPE Gene: 
MEPE (matrix extracellular phosphoglycoprotein) is a protein-coding gene. Diseases associated with MEPE include hypophosphatemic rickets, autosomal dominant, and hereditary hypophosphatemic rickets, and among its related super-pathways are FAK1 Signaling and MAPK Signaling. GO annotations related to this gene include extracellular matrix structural constituent and protein binding.

UniProtKB/Swiss-Prot: MEPE_HUMAN, Q9NQ76
Function: Promotes renal phosphate excretion and modulates mineralization

Gene Wiki entry for MEPE Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MEPE gene promoter:
         AP-1   AML1a   HOXA3   Nkx2-2   CBF-A   FOXO1a   FOXO1   RSRFC4   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMEPE promoter sequence
   Search SABiosciences Chromatin IP Primers for MEPE

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEPE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.1   Ensembl cytogenetic band:  4q22.1   HGNC cytogenetic band: 4q21.1

MEPE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEPE gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P088754:  view genomic region     (about GC identifiers)

Start:
88,742,563 bp from pter      End:
88,767,969 bp from pter
Size:
25,407 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MEPE_HUMAN, Q9NQ76 (See protein sequence)
Recommended Name: Matrix extracellular phosphoglycoprotein precursor  
Size: 525 amino acids; 58419 Da
Subcellular location: Secreted, extracellular space, extracellular matrix
Secondary accessions: A1A4X9 A8MTA3 D2CFR4 F5H5C5
Alternative splicing: 3 isoforms:  Q9NQ76-1   Q9NQ76-2   Q9NQ76-3   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for MEPE: NX_Q9NQ76

Explore proteomics data for MEPE at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated (in vitro) by FAM20C in the extracellular medium at sites within the S-x-E/pS motif
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NQ76

  • MEPE Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MEPE Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001171623.1  NP_001171624.1  NP_001171625.1  NP_001171626.1  NP_064588.1  

    ENSEMBL proteins: 
     ENSP00000378534   ENSP00000422747   ENSP00000421430   ENSP00000354341   ENSP00000416984  
     ENSP00000453994   ENSP00000443491  

    Human Recombinant Protein Products for MEPE: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for MEPE (MEPE/OF45)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for MEPE
    GenScript Custom Purified and Recombinant Proteins Services for MEPE
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MEPE 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--

    MEPE for ontologies           About GeneDecksing



    MEPE Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals MEPE Antibody
    Abcam antibodies for MEPE
    Cloud-Clone Corp. Antibodies for MEPE 
    Search ThermoFisher Antibodies for MEPE
    LSBio Antibodies in human, mouse, rat for MEPE 

    Assay Products for MEPE: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for MEPE
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MEPE 
    Cloud-Clone Corp. CLIAs for MEPE


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR009837 Osteoregulin

    Graphical View of Domain Structure for InterPro Entry Q9NQ76

    ProtoNet protein and cluster: Q9NQ76


    MEPE for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MEPE_HUMAN, Q9NQ76
    Function: Promotes renal phosphate excretion and modulates mineralization

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005201extracellular matrix structural constituent TAS10945470
    GO:0005515protein binding IPI17474147
         
    MEPE for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MEPE:
     Synthetic lethal with c-Myc af 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mepe):
     immune system  skeleton 

    MEPE for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mepetm1Tbrw for MEPE

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MEPE 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MEPE

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MEPE 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MEPE 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MEPE
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate MEPE:
    hsa-miR-3618 hsa-miR-758
    SwitchGear 3'UTR luciferase reporter plasmidMEPE 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MEPE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEPE

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of MEPE

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MEPE (see all 18)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): MEPE (NM_020203)
    Sino Biological Human cDNA Clone for MEPE
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEPE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEPE
    Sirion Biotech Customized lentivirus for stable overexpression of MEPE 
                         Customized lentivirus expression plasmids for stable overexpression of MEPE 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MEPE
    Search LifeMap BioReagents cell lines for MEPE
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEPE


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MEPE About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Integrin Pathway
    Integrin Pathway0.67
    UPA-UPAR Pathway0.56
    FAK1 Signaling0.67
    Inhibition of Angiogenesis by TSP10.50
    GnRH Signaling0.56
    Transendothelial Migration of Leukocytes0.38
    2Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    3PTEN Pathway
    PTEN Pathway0.56
    Phospholipase-C Pathway0.56

    5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MEPE (see all 13)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MEPE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for MEPE (Q9NQ761, 3 ENSP000003543414) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCK1P163331, 3, ENSP000002889864EBI-1753293,EBI-389883 I2D: score=1 STRING: ENSP00000288986
    ABL1P005193, ENSP000003614234I2D: score=1 STRING: ENSP00000361423
    CRKP461083, ENSP000003005744I2D: score=1 STRING: ENSP00000300574
    FYNP062413, ENSP000003576564I2D: score=1 STRING: ENSP00000357656
    PIK3R1P279863, ENSP000002743354I2D: score=1 STRING: ENSP00000274335
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS10945470
    GO:0030502negative regulation of bone mineralization IEA--
    GO:0031214biomineral tissue development IEA--

    MEPE for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MEPE for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MEPE

    1 Novoseek inferred chemical compound relationship for MEPE gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcitriol 46.9 1 19352177 (1)

    Search CenterWatch for drugs/clinical trials and news about MEPE

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MEPE gene (5 alternative transcripts): 
    NM_001184694.1  NM_001184695.1  NM_001184696.1  NM_001184697.1  NM_020203.3  

    Unigene Cluster for MEPE:

    Matrix extracellular phosphoglycoprotein
    Hs.676357  [show with all ESTs]
    Unigene Representative Sequence: NM_001184697
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395102 ENST00000497649 ENST00000515821 ENST00000508016 ENST00000511670
    ENST00000361056 ENST00000424957(uc021xpu.1) ENST00000560249(uc010ikn.3 uc021xpx.1)
    ENST00000540395(uc021xpv.1 uc021xpw.1 uc003hqy.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MEPE
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate MEPE:
    hsa-miR-3618 hsa-miR-758
    SwitchGear 3'UTR luciferase reporter plasmidMEPE 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MEPE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEPE
    Clone
    Products:
         
    OriGene clones in human, mouse for MEPE (see all 18)
    OriGene ORF clones in mouse, rat for MEPE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): MEPE (NM_020203)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEPE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEPE
    Sirion Biotech Customized lentivirus for stable overexpression of MEPE 
                         Customized lentivirus expression plasmids for stable overexpression of MEPE 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MEPE
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MEPE
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEPE
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEPE

    Additional mRNA sequence: 

    AF325916.1 AJ276396.1 AK075076.1 AK307774.1 BC128157.1 BC128158.1 DQ854717.1 

    2 DOTS entries:

    DT.92020012  DT.99940802 

    7 AceView cDNA sequences:

    CA427796 AF325916 NM_020203 CA436651 CA436639 AJ276396 AK075076 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MEPE expression in normal human tissues (normalized intensities)      MEPE embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MEPE Expression
    About this image


    MEPE expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 7 entries
             Endochondral Osteocytes Zeugopod Periosteum
             bone marrow   
     
     Blood (Muscoskeletal System)
             bone marrow   

    See MEPE Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MEPE

    SOURCE GeneReport for Unigene cluster: Hs.676357

    UniProtKB/Swiss-Prot: MEPE_HUMAN, Q9NQ76
    Tissue specificity: Expressed by osteoblasts. Secreted from oncogenic hypophosphataemic tumors

        SABiosciences Custom PCR Arrays for MEPE
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEPE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for MEPE gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mepe1 , 5 matrix extracellular phosphoglycoprotein with ASARM motif (bone) less1, 5 68.16(n)1
    53.85(a)1
      5 (50.68 cM)5
    941111  NM_053172.21  NP_444402.21 
     1043253295 


    ENSEMBL Gene Tree for MEPE (if available)
    TreeFam Gene Tree for MEPE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/681 SNPs in MEPE are shown (see all 681)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs125074471,2
    C,F,H--88740689(+) gaagtC/Ggggga 1 -- us2k16Minor allele frequency- G:0.19NA WA EA 364
    rs1459483281,2
    --88740751(+) CCTCAC/TGCCCA 1 -- us2k10--------
    rs1116007331,2
    C,F--88740752(+) CTCACG/ACCCAC 1 -- us2k12Minor allele frequency- A:0.04CSA WA 119
    rs1151203161,2
    C,F--88740763(+) CGTGTC/ACCCAC 1 -- us2k11Minor allele frequency- A:0.24WA 118
    rs1856358561,2
    --88740907(+) ATGCCA/CTCCCC 1 -- us2k10--------
    rs1132077851,2
    F--88740913(+) TCCCCG/AGAGTT 1 -- us2k12Minor allele frequency- A:0.04CSA WA 120
    rs726557741,2
    C,F--88740921(+) GTTCTG/AGCCAG 1 -- us2k15Minor allele frequency- A:0.15WA NA EA 362
    rs1893160331,2
    --88741005(+) CTGCTC/TCTCTG 1 -- us2k10--------
    rs791201691,2
    C,F--88741198(+) AGGTGT/GGTGTT 1 -- us2k15Minor allele frequency- G:0.04WA CSA NA EA 362
    rs1807990641,2
    --88741265(+) AGGTGG/TCTCCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MEPE (88742563 - 88767969 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MEPE:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv94n17CNV Loss16327808
    nsv822637CNV Gain20364138
    esv275333CNV Gain+Loss21479260

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MEPE
    DNA2.0 Custom Variant and Variant Library Synthesis for MEPE

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605912    OMIM disorders: --

    20 diseases for MEPE:    About MalaCards
    hypophosphatemic rickets, autosomal dominant    hereditary hypophosphatemic rickets    oncogenic osteomalacia    osteomalacia
    x-linked hypophosphatemia    hypophosphatemia    dentin dysplasia    rickets
    paraneoplastic syndromes    dentinogenesis imperfecta    calcinosis    craniosynostosis
    osteosarcoma    dermatomyositis    migraine    oral cancer
    kidney disease    periodontitis    prostate cancer    prostatitis

    6 diseases from the University of Copenhagen DISEASES database for MEPE:
    X-linked hypophosphatemia     Osteomalacia     Hypophosphatemia     Dentin dysplasia
    Rickets     Dentinogenesis imperfecta

    MEPE for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for MEPE gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rickets hypophosphatemic 90.9 9 15040834 (1), 18288501 (1), 14962809 (1), 19998030 (1)
    osteomalacia 86.5 33 15108058 (5), 11414762 (2), 10945470 (1), 15268910 (1) (see all 13)
    hypophosphatemic rickets, autosomal dominant 83.7 2 18288501 (1)
    hypophosphatemia 81.7 5 18037620 (2), 18288501 (1)
    rickets 63.8 3 15040834 (1), 18037620 (1)
    osteoporosis 30 3 15108058 (3)
    osteosarcoma 12.1 1 15268910 (1)
    tumors 2.7 14 10945470 (3), 15108058 (2), 19000546 (1), 14962809 (1) (see all 6)

    Genetic Association Database (GAD): MEPE
    Human Genome Epidemiology (HuGE) Navigator: MEPE (4 documents)

    Export disorders for MEPE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MEPE gene, integrated from 9 sources (see all 87):
    (articles sorted by number of sources associating them with MEPE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia. (PubMed id 10945470)1, 2, 3, 9 Rowe P.S.N.... Oudet C.L. (2000)
    2. Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone. (PubMed id 11414762)1, 2, 9 Argiro L.... Ecarot B. (2001)
    3. Genetic determinants of cardiovascular events among w omen with migraine: a genome-wide association study. (PubMed id 21779381)1, 4 SchA1rks M....Kurth T. (2011)
    4. Twenty bone-mineral-density loci identified by large- scale meta-analysis of genome-wide association studies. (PubMed id 19801982)1, 4 Rivadeneira F....Uitterlinden A.G. (2009)
    5. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)
    6. Matrix extracellular phosphoglycoprotein (MEPE) is highly expressed in osteocytes in human bone. (PubMed id 15108058)1, 9 Nampei A....Yoshikawa H. (2004)
    7. Serum levels of matrix extracellular phosphoglycoprotein (MEPE) in normal humans correlate with serum phosphorus, parathyroid hormone and bone mineral density. (PubMed id 15292364)1, 9 Jain A....Fisher L.W. (2004)
    8. FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization. (PubMed id 12791601)1, 9 Quarles L.D. (2003)
    9. Patterns of FGF-23, DMP1, and MEPE expression in pati ents with chronic kidney disease. (PubMed id 19679205)1, 9 Pereira R.C....Wesseling-Perry K. (2009)
    10. [Expression of matrix extracellular phosphoglycoprotein mRNA in human periodontal ligament cell osteogenic differentiation] (PubMed id 19031789)1, 9 Wu L.P....Liu L. (2008)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56955 HGNC: 13361 AceView: MEPE Ensembl:ENSG00000152595 euGenes: HUgn56955
    ECgene: MEPE H-InvDB: MEPE

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for MEPE Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MEPE Genetics and Cytogenetics in Oncology and Haematology

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