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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MEPE Gene

protein-coding   GIFtS: 51
GCID: GC04P088754

matrix extracellular phosphoglycoprotein

(Previous names: matrix, extracellular phosphoglycoprotein with ASARM motif...)
 Explore 21 diseases affiliated with
MEPE via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MEPE    

Aliases
for MEPE gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Matrix Extracellular Phosphoglycoprotein1 2
Matrix, Extracellular Phosphoglycoprotein With ASARM Motif (Bone)1 2
Osteoblast/Osteocyte Factor 452 3
OF452 3

External Ids:    HGNC: 133611   Entrez Gene: 569552   Ensembl: ENSG000001525957   OMIM: 6059125   UniProtKB: Q9NQ763   

Export aliases for MEPE gene to outside databases

Previous GC identifers: GC04P088911 GC04P089055 GC04P089212 GC04P089191 GC04P089099 GC04P088961 GC04P084488


Summaries
for MEPE gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: MEPE_HUMAN, Q9NQ76
Function: Promotes renal phosphate excretion and modulates mineralization

Gene Wiki entry for MEPE


Genomic Views
for MEPE gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MEPE gene promoter:
         AP-1   AML1a   HOXA3   Nkx2-2   CBF-A   FOXO1a   FOXO1   RSRFC4   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MEPE promoter sequence
   Search SABiosciences Chromatin IP Primers for MEPE

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEPE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.1   Ensembl cytogenetic band:  4q22.1   HGNC cytogenetic band: 4q21.1

MEPE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEPE gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P088754:  view genomic region     (about GC identifiers)

Start:
 88,742,563 bp from pter      End:
 88,767,969 bp from pter
Size:
 25,407 bases      Orientation:
 plus strand

Proteins
for MEPE gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MEPE_HUMAN, Q9NQ76 (See protein sequence)
Recommended Name: Matrix extracellular phosphoglycoprotein precursor  
Size: 525 amino acids; 58419 Da
Subcellular location: Secreted, extracellular space, extracellular matrix
Secondary accessions: A1A4X9 A8MTA3 D2CFR4
Alternative splicing: 2 isoforms:  Q9NQ76-1   Q9NQ76-2   

Explore the universe of human proteins at neXtProt for MEPE: NX_Q9NQ76

Post-translational modifications:

  • Phosphorylated (in vitro) by FAM20C in the extracellular medium at sites within the S-x-E/pS motif1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NQ76

    • MEPE Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001171623.1  NP_001171624.1  NP_001171625.1  NP_001171626.1  NP_064588.1  

    ENSEMBL proteins: 
     ENSP00000378534   ENSP00000422747   ENSP00000421430   ENSP00000354341   ENSP00000416984  
     ENSP00000453994   ENSP00000443491  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for MEPE (MEPE/OF45)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for MEPE 
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MEPE

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--


    MEPE for ontologies           About GeneDecksing



    MEPE Antibody Products: 
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    Assay Products for MEPE: 
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    Uscn ELISAs and CLIAs for MEPE

    Protein Domains /
    Families
    for MEPE gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MEPE for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR009837 Osteoregulin

    Graphical View of Domain Structure for InterPro Entry Q9NQ76

    ProtoNet protein and cluster: Q9NQ76


    Function
    for MEPE gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MEPE_HUMAN, Q9NQ76
    Function: Promotes renal phosphate excretion and modulates mineralization

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MEPE
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate MEPE:
    hsa-miR-3618 hsa-miR-758
    SwitchGear 3'UTR luciferase reporter plasmid: MEPE 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MEPE (see all 7)
    OriGene shRNA RFP: MEPE
    OriGene siRNA: MEPE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEPE

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MEPE

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEPE (see all 7)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 5): MEPE (NM_020203)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEPE 

    Cell Line
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    Search LifeMap BioReagents cell lines for MEPE

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEPE

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005201extracellular matrix structural constituent TAS10945470
    GO:0005515protein binding IPI17474147


    MEPE for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MEPE:
     Synthetic lethal with c-Myc af 

    Animal Models:
         Mouse knock-out Mepetm1Tbrw for MEPE
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mepe):
     immune system  skeleton 

    MEPE for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MEPE gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Integrin Pathway
    		Integrin Pathway1.00
    		UPA-UPAR Pathway0.51
    		FAK1 Signaling0.67
    		Transendothelial Migration of Leukocytes0.38
    		GnRH Signaling0.56
    		Inhibition of Angiogenesis by TSP10.37
    2Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51
    3PTEN Pathway
    		PTEN Pathway1.00
    		Phospholipase-C Pathway0.56

    5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MEPE (see all 13)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MEPE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for MEPE (Q9NQ761, 3 ENSP000003543414) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCK1P163331, 3, ENSP000002889864EBI-1753293,EBI-3448658 I2D: score=1 STRING: ENSP00000288986
    ABL1P005193, ENSP000003614234I2D: score=1 STRING: ENSP00000361423
    CRKP461083, ENSP000003005744I2D: score=1 STRING: ENSP00000300574
    FYNP062413, ENSP000003576564I2D: score=1 STRING: ENSP00000357656
    PIK3R1P279863, ENSP000002743354I2D: score=1 STRING: ENSP00000274335
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS10945470
    GO:0030502negative regulation of bone mineralization IEA--
    GO:0031214biomineral tissue development IEA--


    MEPE for ontologies           About GeneDecksing



    Drugs & Compounds
    for MEPE gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MEPE for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MEPE
    1 Novoseek chemical compound relationship for MEPE gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcitriol 46.9 1 19352177 (1)

    Search CenterWatch for drugs/clinical trials and news about MEPE 

    Transcripts
    for MEPE gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MEPE gene (5 alternative transcripts): 
    NM_001184694.1  NM_001184695.1  NM_001184696.1  NM_001184697.1  NM_020203.3  

    Unigene Cluster for MEPE:

    Matrix extracellular phosphoglycoprotein
    Hs.676357  [show with all ESTs]
    Unigene Representative Sequence: NM_001184697
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395102 ENST00000497649 ENST00000515821 ENST00000508016 ENST00000511670
    ENST00000361056 ENST00000424957(uc021xpu.1) ENST00000560249(uc010ikn.3 uc021xpx.1)
    ENST00000540395(uc021xpv.1 uc021xpw.1 uc003hqy.3)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MEPE
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate MEPE:
    hsa-miR-3618 hsa-miR-758
    SwitchGear 3'UTR luciferase reporter plasmid: MEPE 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MEPE (see all 7)
    OriGene shRNA RFP: MEPE
    OriGene siRNA: MEPE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEPE
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEPE (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEPE (see all 5)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 5): MEPE (NM_020203)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEPE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEPE 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MEPE
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MEPE
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEPE
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEPE

    Additional cDNA sequence: 

    AF325916.1 AJ276396.1 AK075076.1 AK307774.1 BC128157.1 BC128158.1 DQ854717.1 

    2 DOTS entries:

    DT.92020012  DT.99940802 

    7 AceView cDNA sequences:

    CA427796 AF325916 AK075076 AJ276396 CA436639 NM_020203 CA436651 

    GeneLoc Exon Structure


    Expression
    for MEPE gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MEPE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MEPE expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneAutopod PeriosteumEndochondral OsteocytesBone
    BoneCaudal Endochondral BonesEndochondral OsteocytesBone
    BoneEndochondral Facial BonesEndochondral OsteocytesBone
    BoneRostral Endochondral Facial BonesEndochondral OsteocytesBone
    BoneStylopod PeriosteumEndochondral OsteocytesBone
    BoneZeugopod PeriosteumEndochondral OsteocytesBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MEPE Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MEPE

    SOURCE GeneReport for Unigene cluster: Hs.676357

    UniProtKB/Swiss-Prot: MEPE_HUMAN, Q9NQ76
    Tissue specificity: Expressed by osteoblasts. Secreted from oncogenic hypophosphataemic tumors

        SABiosciences Custom PCR Arrays for MEPE
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEPE

    Orthologs
    for MEPE gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of human and mouse.

    Orthologs for MEPE gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Mepe1 , 5 matrix extracellular phosphoglycoprotein with ASARM more1, 5 68.16(n)1
    53.85(a)1    		   5 (50.68 cM)5
    941111  NM_053172.21  NP_444402.21 
     1043253295 


    ENSEMBL Gene Tree for MEPE (if available)
    TreeFam Gene Tree for MEPE (if available) 

    Paralogs
    for MEPE gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for MEPE gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for MEPE
         3 Indels: 10768 10769 10767
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MEPE
    DNA2.0 Custom Variant and Variant Library Synthesis for MEPE

    Disorders / Diseases
    for MEPE gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MEPE for disorders           About GeneDecksing

    OMIM gene information: 605912    OMIM disorders: --

    20/21 diseases for MEPE (see all 21):    About MalaCards
    hypophosphatemic rickets, autosomal dominant    hereditary hypophosphatemic rickets    oncogenic osteomalacia    rickets
    dentinogenesis imperfecta    hypophosphatemia    osteomalacia    dentin dysplasia
    paraneoplastic syndromes    calcinosis    craniosynostosis    osteoporosis
    nevus    dermatomyositis    osteosarcoma    kidney disease
    migraine    oral cancer    periodontitis    prostate cancer

    6 diseases from the University of Copenhagen DISEASES database for MEPE:
    X-linked hypophosphatemia     Osteomalacia     Hypophosphatemia     Dentin dysplasia
    Rickets     Dentinogenesis imperfecta

    8 Novoseek disease relationships for MEPE gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rickets hypophosphatemic 90.9 9 15040834 (1), 18288501 (1), 14962809 (1), 19998030 (1)
    osteomalacia 86.5 33 15108058 (5), 11414762 (2), 10945470 (1), 15268910 (1) (see all 13)
    hypophosphatemic rickets, autosomal dominant 83.7 2 18288501 (1)
    hypophosphatemia 81.7 5 18037620 (2), 18288501 (1)
    rickets 63.8 3 15040834 (1), 18037620 (1)
    osteoporosis 30 3 15108058 (3)
    osteosarcoma 12.1 1 15268910 (1)
    tumors 2.7 14 10945470 (3), 15108058 (2), 19000546 (1), 14962809 (1) (see all 6)

    Human Genome Epidemiology (HuGE) Navigator: MEPE (4 documents)

    Export disorders for MEPE gene to outside databases

    Publications
    for MEPE gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MEPE gene, integrated from 9 sources (see all 84):
    (articles sorted by number of sources associating them with MEPE)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia. (PubMed id 10945470)1, 2, 3, 9 Rowe P.S.N.... Oudet C.L. (2000)
    2. Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone. (PubMed id 11414762)1, 2, 9 Argiro L.... Ecarot B. (2001)
    3. Matrix extracellular phosphoglycoprotein (MEPE) is highly expressed in osteocytes in human bone. (PubMed id 15108058)1, 9 Nampei A....Yoshikawa H. (2004)
    4. Serum levels of matrix extracellular phosphoglycoprotein (MEPE) in normal humans correlate with serum phosphorus, parathyroid hormone and bone mineral density. (PubMed id 15292364)1, 9 Jain A....Fisher L.W. (2004)
    5. FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization. (PubMed id 12791601)1, 9 Quarles L.D. (2003)
    6. Patterns of FGF-23, DMP1, and MEPE expression in pati ents with chronic kidney disease. (PubMed id 19679205)1, 9 Pereira R.C....Wesseling-Perry K. (2009)
    7. [Expression of matrix extracellular phosphoglycoprotein mRNA in human periodontal ligament cell osteogenic differentiation] (PubMed id 19031789)1, 9 Wu L.P....Liu L. (2008)
    8. Matrix extracellular phosphoglycoprotein inhibits phosphate transport. (PubMed id 19005008)1, 9 Marks J....Unwin R.J. (2008)
    9. Changes in matrix extracellular phosphoglycoprotein expression before and during in vitro osteogenic differentiation of human dental papilla mesenchymal cells. (PubMed id 18547474)1, 9 Tete S....Ciccarelli R. (2008)
    10. MEPE has the properties of an osteoblastic phosphatonin and minhibin. (PubMed id 14962809)2, 9 Rowe P.S....Mundy G.R. (2004)

    External Searches for MEPE gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MEPE gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56955 HGNC: 13361 AceView: MEPE Ensembl:ENSG00000152595 euGenes: HUgn56955
    ECgene: MEPE H-InvDB: MEPE

    Other Databases showing MEPE gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MEPE gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MEPE Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MEPE Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MEPE gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MEPE gene:
    Search GeneIP for patents involving MEPE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
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     MEPE Proteins, Antibodies, CLIAs, and ELISAs
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