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MEPE Gene

protein-coding   GIFtS: 51
GCID: GC04P088754

Matrix Extracellular Phosphoglycoprotein

(Previous names: matrix, extracellular phosphoglycoprotein with ASARM motif...)
  See MEPE-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Matrix Extracellular Phosphoglycoprotein1 2
Matrix, Extracellular Phosphoglycoprotein With ASARM Motif (Bone)1 2
Osteoblast/Osteocyte Factor 452 3
OF452 3

External Ids:    HGNC: 133611   Entrez Gene: 569552   Ensembl: ENSG000001525957   OMIM: 6059125   UniProtKB: Q9NQ763   

Export aliases for MEPE gene to outside databases

Previous GC identifers: GC04P088911 GC04P089055 GC04P089212 GC04P089191 GC04P089099 GC04P088961 GC04P084488


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MEPE Gene:
This gene encodes a secreted calcium-binding phosphoprotein that belongs to the small integrin-binding ligand,
N-linked glycoprotein (SIBLING) family of proteins. Members of this family are components of the extracellular
matrix of bone and dentin and regulate bone mineralization. Deficiency of a similar protein in mouse results in
increased bone mass. Mice lacking this gene are resistant to aging-related trabecular bone loss. Alternative
splicing results in multiple transcript variants. (provided by RefSeq, Mar 2014)

GeneCards Summary for MEPE Gene:
MEPE (matrix extracellular phosphoglycoprotein) is a protein-coding gene. Diseases associated with MEPE include hypophosphatemic rickets, autosomal dominant, and oncogenic osteomalacia. GO annotations related to this gene include extracellular matrix structural constituent.

UniProtKB/Swiss-Prot: MEPE_HUMAN, Q9NQ76
Function: Promotes renal phosphate excretion and modulates mineralization

Gene Wiki entry for MEPE Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the MEPE gene promoter:
         AP-1   AML1a   HOXA3   Nkx2-2   CBF-A   FOXO1a   FOXO1   RSRFC4   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMEPE promoter sequence
   Search Chromatin IP Primers for MEPE

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MEPE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.1   Ensembl cytogenetic band:  4q22.1   HGNC cytogenetic band: 4q21.1

MEPE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEPE gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P088754:  view genomic region     (about GC identifiers)

Start:
88,742,563 bp from pter      End:
88,767,969 bp from pter
Size:
25,407 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MEPE_HUMAN, Q9NQ76 (See protein sequence)
Recommended Name: Matrix extracellular phosphoglycoprotein precursor  
Size: 525 amino acids; 58419 Da
Secondary accessions: A1A4X9 A8MTA3 D2CFR4 F5H5C5
Alternative splicing: 3 isoforms:  Q9NQ76-1   Q9NQ76-2   Q9NQ76-3   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for MEPE: NX_Q9NQ76

Explore proteomics data for MEPE at MOPED

Post-translational modifications: 

  • Phosphorylated (in vitro) by FAM20C in the extracellular medium at sites within the S-x-E/pS motif1
  • Glycosylation2 at Asn477, Asn478
  • Modification sites at PhosphoSitePlus

  • See MEPE Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001171623.1  NP_001171624.1  NP_001171625.1  NP_001171626.1  NP_001278112.1  NP_064588.1  

    ENSEMBL proteins: 
     ENSP00000378534   ENSP00000422747   ENSP00000421430   ENSP00000354341   ENSP00000416984  
     ENSP00000453994   ENSP00000443491  

    MEPE Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for MEPE (MEPE/OF45)
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MEPE
    GenScript Custom Purified and Recombinant Proteins Services for MEPE
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MEPE

     
    Search eBioscience for Proteins for MEPE 

     
    antibodies-online proteins for MEPE (2 products) 

     
    antibodies-online peptides for MEPE

    MEPE Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for MEPE (MEPE/OF45)
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    Novus Biologicals MEPE Antibody
    Abcam antibodies for MEPE
    Cloud-Clone Corp. Antibodies for MEPE
    Search ThermoFisher Antibodies for MEPE
    antibodies-online antibodies for MEPE (30 products) 

    MEPE Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for MEPE
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MEPE
    Cloud-Clone Corp. CLIAs for MEPE
    Search eBioscience for ELISAs for MEPE 
    antibodies-online kits for MEPE (25 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009837 Osteoregulin

    Graphical View of Domain Structure for InterPro Entry Q9NQ76

    ProtoNet protein and cluster: Q9NQ76


    Find genes that share domains with MEPE           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MEPE_HUMAN, Q9NQ76
    Function: Promotes renal phosphate excretion and modulates mineralization

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005201extracellular matrix structural constituent TAS10945470
    GO:0005515protein binding IPI17474147
         
    Find genes that share ontologies with MEPE           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MEPE:
     Synthetic lethal with c-Myc af 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mepe):
     hematopoietic system  immune system  skeleton 

    Find genes that share phenotypes with MEPE           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Mepetm1Tbrw for MEPE

       genOway: Develop your customized and physiologically relevant rodent model for MEPE

    miRNA
    Products:
        
    miRTarBase miRNAs that target MEPE:
    hsa-mir-335-5p (MIRT017419), hsa-mir-124-3p (MIRT022428)

    Block miRNA regulation of human, mouse, rat MEPE using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate MEPE:
    hsa-miR-3618 hsa-miR-758
    SwitchGear 3'UTR luciferase reporter plasmidMEPE 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MEPE
    Predesigned siRNA for gene silencing in human, mouse, rat MEPE

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 5): MEPE (NM_020203)
    Sino Biological Human cDNA Clone for MEPE
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEPE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEPE

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MEPE 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEPE


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MEPE_HUMAN, Q9NQ76: Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endoplasmic reticulum2
    cytosol1
    golgi apparatus1
    lysosome1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--

    Find genes that share ontologies with MEPE           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MEPE About    
    See pathways by source

    SuperPathContained pathways About
    1Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Inhibition of Angiogenesis by TSP10.50
    GnRH Signaling0.56
    Transendothelial Migration of Leukocytes0.38
    2ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    3Phospholipase-C Pathway
    Phospholipase-C Pathway0.56
    PTEN Pathway0.56

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MEPE (see all 13)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MEPE
    Interactions:

        Search GeneGlobe Interaction Network for MEPE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for MEPE (Q9NQ761, 3 ENSP000003543414) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCK1P163331, 3, ENSP000002889864EBI-1753293,EBI-389883 I2D: score=1 STRING: ENSP00000288986
    ABL1P005193, ENSP000003614234I2D: score=1 STRING: ENSP00000361423
    CRKP461083, ENSP000003005744I2D: score=1 STRING: ENSP00000300574
    FYNP062413, ENSP000003576564I2D: score=1 STRING: ENSP00000357656
    PIK3R1P279863, ENSP000002743354I2D: score=1 STRING: ENSP00000274335
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS10945470
    GO:0030502negative regulation of bone mineralization IEA--
    GO:0031214biomineral tissue development IEA--
    GO:0046850regulation of bone remodeling IEA--

    Find genes that share ontologies with MEPE           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MEPE

    1 Novoseek inferred chemical compound relationship for MEPE gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcitriol 46.9 1 19352177 (1)



    Find genes that share compounds with MEPE           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MEPE gene (6 alternative transcripts): 
    NM_001184694.2  NM_001184695.1  NM_001184696.1  NM_001184697.1  NM_001291183.1  NM_020203.3  

    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395102 ENST00000497649 ENST00000515821 ENST00000508016 ENST00000511670
    ENST00000361056 ENST00000424957(uc021xpu.1) ENST00000560249(uc010ikn.3 uc021xpx.1)
    ENST00000540395(uc021xpv.1 uc021xpw.1 uc003hqy.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MEPE using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate MEPE:
    hsa-miR-3618 hsa-miR-758
    SwitchGear 3'UTR luciferase reporter plasmidMEPE 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MEPE
    Predesigned siRNA for gene silencing in human, mouse, rat MEPE
    Clone
    Products:
         
    OriGene clones in human, mouse for MEPE (see all 22)
    OriGene ORF clones in mouse, rat for MEPE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): MEPE (NM_020203)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEPE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEPE
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MEPE
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MEPE
      QuantiTect SYBR Green Assays in human, mouse, rat MEPE
      QuantiFast Probe-based Assays in human, mouse, rat MEPE

    7 AceView cDNA sequences:

    AF325916 CA427796 CA436639 AJ276396 CA436651 AK075076 NM_020203 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MEPE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MEPE Expression
    About this image


    MEPE expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 7 entries
             Endochondral Osteocytes Zeugopod Periosteum
             bone marrow   
     
     Tooth (Integumentary System)    fully expand to see all 3 entries
             Stem cells from human exfoliated deciduous teeth (family)
     
     Blood (Cardiovascular System)
             bone marrow   
    MEPE Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MEPE Protein Expression

    UniProtKB/Swiss-Prot: MEPE_HUMAN, Q9NQ76
    Tissue specificity: Expressed by osteoblasts. Secreted from oncogenic hypophosphataemic tumors

        Custom PCR Arrays for MEPE
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEPE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for MEPE gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mepe1 , 5 matrix extracellular phosphoglycoprotein with ASARM more1, 5 67.81(n)1
    52.12(a)1
      5 (50.68 cM)5
    941111  NM_053172.21  NP_444402.21 
     1043253295 


    ENSEMBL Gene Tree for MEPE (if available)
    TreeFam Gene Tree for MEPE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MEPE (see all 681)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs125074471,2
    C,F,H--88740689(+) gaagtC/Ggggga 1 -- us2k16Minor allele frequency- G:0.19NA WA EA 364
    rs1459483281,2
    --88740751(+) CCTCAC/TGCCCA 1 -- us2k10--------
    rs1116007331,2
    C,F--88740752(+) CTCACG/ACCCAC 1 -- us2k12Minor allele frequency- A:0.04CSA WA 119
    rs1151203161,2
    C,F--88740763(+) CGTGTC/ACCCAC 1 -- us2k11Minor allele frequency- A:0.24WA 118
    rs1856358561,2
    --88740907(+) ATGCCA/CTCCCC 1 -- us2k10--------
    rs1132077851,2
    F--88740913(+) TCCCCG/AGAGTT 1 -- us2k12Minor allele frequency- A:0.04CSA WA 120
    rs726557741,2
    C,F--88740921(+) GTTCTG/AGCCAG 1 -- us2k15Minor allele frequency- A:0.15WA NA EA 362
    rs1893160331,2
    --88741005(+) CTGCTC/TCTCTG 1 -- us2k10--------
    rs791201691,2
    C,F--88741198(+) AGGTGT/GGTGTT 1 -- us2k15Minor allele frequency- G:0.04WA CSA NA EA 362
    rs1807990641,2
    --88741265(+) AGGTGG/TCTCCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MEPE (88742563 - 88767969 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MEPE:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv94n17CNV Loss16327808
    nsv822637CNV Gain20364138
    esv275333CNV Gain+Loss21479260

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MEPE
    DNA2.0 Custom Variant and Variant Library Synthesis for MEPE

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605912    OMIM disorders: --

    4 diseases for MEPE:    
    About MalaCards
    hypophosphatemic rickets, autosomal dominant    oncogenic osteomalacia    dentin dysplasia    dentinogenesis imperfecta

    6 diseases from the University of Copenhagen DISEASES database for MEPE:
    X-linked hypophosphatemia     Osteomalacia     Hypophosphatemia     Dentin dysplasia
    Rickets     Dentinogenesis imperfecta

    Find genes that share disorders with MEPE           About GenesLikeMe

    8 Novoseek inferred disease relationships for MEPE gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rickets hypophosphatemic 90.9 9 15040834 (1), 18288501 (1), 14962809 (1), 19998030 (1)
    osteomalacia 86.5 33 15108058 (5), 11414762 (2), 10945470 (1), 15268910 (1) (see all 13)
    hypophosphatemic rickets, autosomal dominant 83.7 2 18288501 (1)
    hypophosphatemia 81.7 5 18037620 (2), 18288501 (1)
    rickets 63.8 3 15040834 (1), 18037620 (1)
    osteoporosis 30 3 15108058 (3)
    osteosarcoma 12.1 1 15268910 (1)
    tumors 2.7 14 10945470 (3), 15108058 (2), 19000546 (1), 14962809 (1) (see all 6)

    Genetic Association Database (GAD): MEPE
    Human Genome Epidemiology (HuGE) Navigator: MEPE (4 documents)

    Export disorders for MEPE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MEPE gene, integrated from 10 sources (see all 89):
    (articles sorted by number of sources associating them with MEPE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia. (PubMed id 10945470)1, 2, 3, 9 Rowe P.S.N.... Oudet C.L. (Genomics 2000)
    2. Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone. (PubMed id 11414762)1, 2, 9 Argiro L.... Ecarot B. (Genomics 2001)
    3. Secreted kinase phosphorylates extracellular proteins that regulate biomineralization. (PubMed id 22582013)1, 2 Tagliabracci V.S.... Dixon J.E. (Science 2012)
    4. Genetic determinants of cardiovascular events among women with migraine: a genome-wide association study. (PubMed id 21779381)1, 4 SchA1rks M....Kurth T. (PLoS ONE 2011)
    5. Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. (PubMed id 19801982)1, 4 Rivadeneira F....Uitterlinden A.G. (Nat. Genet. 2009)
    6. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    7. Matrix extracellular phosphoglycoprotein (MEPE) is highly expressed in osteocytes in human bone. (PubMed id 15108058)1, 9 Nampei A....Yoshikawa H. (J. Bone Miner. Metab. 2004)
    8. Serum levels of matrix extracellular phosphoglycoprotein (MEPE) in normal humans correlate with serum phosphorus, parathyroid hormone and bone mineral density. (PubMed id 15292364)1, 9 Jain A....Fisher L.W. (J. Clin. Endocrinol. Metab. 2004)
    9. FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization. (PubMed id 12791601)1, 9 Quarles L.D. (Am. J. Physiol. Endocrinol. Metab. 2003)
    10. Patterns of FGF-23, DMP1, and MEPE expression in patients with chronic kidney disease. (PubMed id 19679205)1, 9 Pereira R.C....Wesseling-Perry K. (Bone 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56955 HGNC: 13361 AceView: MEPE Ensembl:ENSG00000152595 euGenes: HUgn56955
    ECgene: MEPE H-InvDB: MEPE

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MEPE Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MEPE Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MEPE gene:
    Search GeneIP for patents involving MEPE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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