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Aliases for MEPCE Gene

Aliases for MEPCE Gene

  • Methylphosphate Capping Enzyme 2 3
  • BCDIN3 3 4 6
  • Bicoid-Interacting Protein 3 Homolog 3 4
  • Bin3 Homolog 3 4
  • Bin3, Bicoid-Interacting 3, Homolog (Drosophila) 2
  • 7SK SnRNA Methylphosphate Capping Enzyme 3
  • Bin3, Bicoid-Interacting 3, Homolog 3
  • EC 2.1.1.- 4
  • MePCE 4

External Ids for MEPCE Gene

Previous HGNC Symbols for MEPCE Gene

  • BCDIN3

Previous GeneCards Identifiers for MEPCE Gene

  • GC07P099866
  • GC07P100026
  • GC07P094659

Summaries for MEPCE Gene

GeneCards Summary for MEPCE Gene

MEPCE (Methylphosphate Capping Enzyme) is a Protein Coding gene. GO annotations related to this gene include RNA methyltransferase activity and S-adenosylmethionine-dependent methyltransferase activity.

UniProtKB/Swiss-Prot for MEPCE Gene

  • S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5-end of 7SK snRNA, leading to stabilize it.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEPCE Gene

Genomics for MEPCE Gene

Regulatory Elements for MEPCE Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MEPCE Gene

Start:
100,428,790 bp from pter
End:
100,434,126 bp from pter
Size:
5,337 bases
Orientation:
Plus strand

Genomic View for MEPCE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MEPCE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEPCE Gene

Proteins for MEPCE Gene

  • Protein details for MEPCE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L2J0-MEPCE_HUMAN
    Recommended name:
    7SK snRNA methylphosphate capping enzyme
    Protein Accession:
    Q7L2J0
    Secondary Accessions:
    • B3KP86
    • D6W5V7
    • Q9NPD4

    Protein attributes for MEPCE Gene

    Size:
    689 amino acids
    Molecular mass:
    74355 Da
    Quaternary structure:
    • Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, MEPCE/BCDIN3, SART3 proteins and 7SK and U6 snRNAs.
    SequenceCaution:
    • Sequence=AAF74767.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH16396.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91040.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MEPCE Gene

    Alternative splice isoforms for MEPCE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEPCE Gene

Proteomics data for MEPCE Gene at MOPED

Post-translational modifications for MEPCE Gene

  • Ubiquitination at Lys635
  • Modification sites at PhosphoSitePlus

Other Protein References for MEPCE Gene

Antibody Products

No data available for DME Specific Peptides for MEPCE Gene

Domains for MEPCE Gene

Protein Domains for MEPCE Gene

Suggested Antigen Peptide Sequences for MEPCE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L2J0

UniProtKB/Swiss-Prot:

MEPCE_HUMAN :
  • Q7L2J0
Domain:
  • Contains 1 Bin3-type SAM domain.
Family:
  • Belongs to the methyltransferase superfamily.
genes like me logo Genes that share domains with MEPCE: view

No data available for Gene Families for MEPCE Gene

Function for MEPCE Gene

Molecular function for MEPCE Gene

UniProtKB/Swiss-Prot Function:
S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5-end of 7SK snRNA, leading to stabilize it.

Enzyme Numbers (IUBMB) for MEPCE Gene

Gene Ontology (GO) - Molecular Function for MEPCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity --
GO:0008173 RNA methyltransferase activity IDA 17643375
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity IDA 17643375
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MEPCE: view
genes like me logo Genes that share phenotypes with MEPCE: view

Animal Model Products

CRISPR Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MEPCE Gene

Localization for MEPCE Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MEPCE Gene COMPARTMENTS Subcellular localization image for MEPCE gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MEPCE Gene

Pathways for MEPCE Gene

SuperPathways for MEPCE Gene

No Data Available

Gene Ontology (GO) - Biological Process for MEPCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001510 RNA methylation IDA 17643375
GO:0016073 snRNA metabolic process IDA 17643375
GO:0035562 negative regulation of chromatin binding IEA --
GO:0040031 snRNA modification IDA 17643375
genes like me logo Genes that share ontologies with MEPCE: view

No data available for Pathways by source for MEPCE Gene

Compounds for MEPCE Gene

(1) HMDB Compounds for MEPCE Gene

Compound Synonyms Cas Number PubMed IDs
S-Adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
29908-03-0
genes like me logo Genes that share compounds with MEPCE: view

Transcripts for MEPCE Gene

Unigene Clusters for MEPCE Gene

Methylphosphate capping enzyme:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MEPCE

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEPCE Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
SP1:
SP2: - - - - -
SP3: - - - -
SP4: - -
SP5: - - -
SP6:
SP7: - -

Relevant External Links for MEPCE Gene

GeneLoc Exon Structure for
MEPCE
ECgene alternative splicing isoforms for
MEPCE

Expression for MEPCE Gene

mRNA expression in normal human tissues for MEPCE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for MEPCE Gene

This gene is overexpressed in Lung (22.8), Peripheral blood mononuclear cells (14.9), and Heart (10.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MEPCE Gene

SOURCE GeneReport for Unigene cluster for MEPCE Gene Hs.178011

mRNA Expression by UniProt/SwissProt for MEPCE Gene

Q7L2J0-MEPCE_HUMAN
Tissue specificity: Expressed in chronic myeloid leukemia cells, adrenal gland, brain, cerebellum, kidney, lung, mammary gland and testis. Weakly or not expressed in other tissues.
genes like me logo Genes that share expressions with MEPCE: view

Expression partners for MEPCE Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MEPCE Gene

Orthologs for MEPCE Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MEPCE Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MEPCE 35
  • 89.89 (n)
  • 90.67 (a)
BCDIN3 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MEPCE 35
  • 91.41 (n)
  • 92.14 (a)
MEPCE 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mepce 35
  • 86.99 (n)
  • 89.11 (a)
Mepce 16
Mepce 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MEPCE 35
  • 99.13 (n)
  • 99.27 (a)
MEPCE 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MEPCE 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MEPCE 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.110 35
zebrafish
(Danio rerio)
Actinopterygii mepce 36
  • 43 (a)
OneToMany
MEPCE (1 of 2) 36
  • 46 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta bin3 36
  • 15 (a)
OneToMany
CG1239 36
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y17G7B.18 36
  • 38 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G51130 35
  • 47.88 (n)
  • 43.63 (a)
rice
(Oryza sativa)
Liliopsida Os08g0540500 35
  • 46.83 (n)
  • 39.43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11343 36
  • 48 (a)
OneToOne
Species with no ortholog for MEPCE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MEPCE Gene

ENSEMBL:
Gene Tree for MEPCE (if available)
TreeFam:
Gene Tree for MEPCE (if available)

Paralogs for MEPCE Gene

No data available for Paralogs for MEPCE Gene

Variants for MEPCE Gene

Sequence variations from dbSNP and Humsavar for MEPCE Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1136496 -- 100,433,737(+) ACCTG(C/T)GCAGC utr-variant-3-prime
rs35613678 -- 100,432,437(+) TCTAG(-/C)AAAAG intron-variant
rs41280974 -- 100,433,209(+) TCGCC(C/G/T)TTGGC intron-variant
rs55721535 -- 100,432,725(+) GGAAG(A/C)AGCAG intron-variant
rs71555279 -- 100,433,384(+) CACCT(C/T)TAAAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MEPCE Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV Deletion 23290073
nsv831071 CNV Loss 17160897
nsv527107 CNV Loss 19592680
dgv7398n71 CNV Loss 21882294
nsv888779 CNV Loss 21882294
dgv1226e199 CNV Deletion 23128226

Relevant External Links for MEPCE Gene

HapMap Linkage Disequilibrium report
MEPCE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEPCE Gene

Disorders for MEPCE Gene

No disorders were found for MEPCE Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MEPCE Gene

Publications for MEPCE Gene

  1. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PMID: 17643375) Jeronimo C. … Coulombe B. (Mol. Cell 2007) 2 3 4
  2. Identification and characterization of a novel gene encoding a SEREX antigen in chronic myeloid leukaemia. (PMID: 12358911) Rogers S.A. … Lim S.H. (Br. J. Haematol. 2002) 2 3 4
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3

Products for MEPCE Gene

  • Addgene plasmids for MEPCE

Sources for MEPCE Gene

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