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Aliases for MEPCE Gene

Aliases for MEPCE Gene

  • Methylphosphate Capping Enzyme 2 3 5
  • Bicoid-Interacting Protein 3 Homolog 3 4
  • Bin3 Homolog 3 4
  • BCDIN3 3 4
  • Bin3, Bicoid-Interacting 3, Homolog (Drosophila) 2
  • Bin3, Bicoid-Interacting 3, Homolog 3
  • EC 2.1.1.- 4
  • MePCE 4

External Ids for MEPCE Gene

Previous HGNC Symbols for MEPCE Gene

  • BCDIN3

Previous GeneCards Identifiers for MEPCE Gene

  • GC07P099866
  • GC07P100026
  • GC07P094659

Summaries for MEPCE Gene

GeneCards Summary for MEPCE Gene

MEPCE (Methylphosphate Capping Enzyme) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and S-adenosylmethionine-dependent methyltransferase activity.

UniProtKB/Swiss-Prot for MEPCE Gene

  • S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5-end of 7SK snRNA, leading to stabilize it.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEPCE Gene

Genomics for MEPCE Gene

Regulatory Elements for MEPCE Gene

Enhancers for MEPCE Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MEPCE on UCSC Golden Path with GeneCards custom track

Promoters for MEPCE Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MEPCE on UCSC Golden Path with GeneCards custom track

Genomic Location for MEPCE Gene

100,428,698 bp from pter
100,434,126 bp from pter
5,429 bases
Plus strand

Genomic View for MEPCE Gene

Genes around MEPCE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEPCE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEPCE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEPCE Gene

Proteins for MEPCE Gene

  • Protein details for MEPCE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    7SK snRNA methylphosphate capping enzyme
    Protein Accession:
    Secondary Accessions:
    • B3KP86
    • D6W5V7
    • Q9NPD4

    Protein attributes for MEPCE Gene

    689 amino acids
    Molecular mass:
    74355 Da
    Quaternary structure:
    • Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, MEPCE/BCDIN3, SART3 proteins and 7SK and U6 snRNAs.
    • Sequence=AAF74767.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH16396.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91040.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MEPCE Gene

    Alternative splice isoforms for MEPCE Gene


neXtProt entry for MEPCE Gene

Proteomics data for MEPCE Gene at MOPED

Post-translational modifications for MEPCE Gene

  • Ubiquitination at Lys 635
  • Modification sites at PhosphoSitePlus

Other Protein References for MEPCE Gene

No data available for DME Specific Peptides for MEPCE Gene

Domains & Families for MEPCE Gene

Protein Domains for MEPCE Gene

Suggested Antigen Peptide Sequences for MEPCE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Bin3-type SAM domain.
  • Belongs to the methyltransferase superfamily.
  • Contains 1 Bin3-type SAM domain.
  • Belongs to the methyltransferase superfamily.
genes like me logo Genes that share domains with MEPCE: view

No data available for Gene Families for MEPCE Gene

Function for MEPCE Gene

Molecular function for MEPCE Gene

UniProtKB/Swiss-Prot Function:
S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5-end of 7SK snRNA, leading to stabilize it.

Enzyme Numbers (IUBMB) for MEPCE Gene

Gene Ontology (GO) - Molecular Function for MEPCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity IDA 17643375
genes like me logo Genes that share ontologies with MEPCE: view
genes like me logo Genes that share phenotypes with MEPCE: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MEPCE Gene

Localization for MEPCE Gene

Subcellular locations from

Jensen Localization Image for MEPCE Gene COMPARTMENTS Subcellular localization image for MEPCE gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MEPCE Gene

Pathways & Interactions for MEPCE Gene

SuperPathways for MEPCE Gene

No Data Available

Gene Ontology (GO) - Biological Process for MEPCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016073 snRNA metabolic process IDA 17643375
GO:0035562 negative regulation of chromatin binding IEA --
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle IEA --
genes like me logo Genes that share ontologies with MEPCE: view

No data available for Pathways by source and SIGNOR curated interactions for MEPCE Gene

Drugs & Compounds for MEPCE Gene

(1) Drugs for MEPCE Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
genes like me logo Genes that share compounds with MEPCE: view

Transcripts for MEPCE Gene

Unigene Clusters for MEPCE Gene

Methylphosphate capping enzyme:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MEPCE Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
SP2: - - - - -
SP3: - - - -
SP4: - -
SP5: - - -
SP7: - -

Relevant External Links for MEPCE Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MEPCE Gene

mRNA expression in normal human tissues for MEPCE Gene

Protein differential expression in normal tissues from HIPED for MEPCE Gene

This gene is overexpressed in Lung (22.8), Peripheral blood mononuclear cells (14.9), and Heart (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MEPCE Gene

SOURCE GeneReport for Unigene cluster for MEPCE Gene Hs.178011

mRNA Expression by UniProt/SwissProt for MEPCE Gene

Tissue specificity: Expressed in chronic myeloid leukemia cells, adrenal gland, brain, cerebellum, kidney, lung, mammary gland and testis. Weakly or not expressed in other tissues.
genes like me logo Genes that share expression patterns with MEPCE: view

Protein tissue co-expression partners for MEPCE Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MEPCE Gene

Orthologs for MEPCE Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MEPCE Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MEPCE 35
  • 89.89 (n)
  • 90.67 (a)
  • 92 (a)
(Canis familiaris)
Mammalia MEPCE 35
  • 91.41 (n)
  • 92.14 (a)
  • 92 (a)
(Mus musculus)
Mammalia Mepce 35
  • 86.99 (n)
  • 89.11 (a)
Mepce 16
Mepce 36
  • 90 (a)
(Pan troglodytes)
Mammalia MEPCE 35
  • 99.13 (n)
  • 99.27 (a)
  • 99 (a)
(Monodelphis domestica)
Mammalia MEPCE 36
  • 80 (a)
(Anolis carolinensis)
Reptilia MEPCE 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.110 35
(Danio rerio)
Actinopterygii mepce 36
  • 43 (a)
MEPCE (1 of 2) 36
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta bin3 36
  • 15 (a)
CG1239 36
  • 39 (a)
(Caenorhabditis elegans)
Secernentea Y17G7B.18 36
  • 38 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G51130 35
  • 47.88 (n)
  • 43.63 (a)
(Oryza sativa)
Liliopsida Os08g0540500 35
  • 46.83 (n)
  • 39.43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11343 36
  • 48 (a)
Species with no ortholog for MEPCE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MEPCE Gene

Gene Tree for MEPCE (if available)
Gene Tree for MEPCE (if available)

Paralogs for MEPCE Gene

No data available for Paralogs for MEPCE Gene

Variants for MEPCE Gene

Sequence variations from dbSNP and Humsavar for MEPCE Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs35613678 -- 100,432,437(+) TCTAG(-/C)AAAAG intron-variant
rs41280974 -- 100,433,209(+) TCGCC(C/G/T)TTGGC intron-variant
rs55721535 -- 100,432,725(+) GGAAG(A/C)AGCAG intron-variant
rs77227535 -- 100,431,812(+) GAGAG(C/T)CTCTG intron-variant
rs139439578 -- 100,432,384(+) TGTTG(G/T)GTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MEPCE Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV Deletion 23290073
nsv831071 CNV Loss 17160897
nsv527107 CNV Loss 19592680
dgv7398n71 CNV Loss 21882294
nsv888779 CNV Loss 21882294
dgv1226e199 CNV Deletion 23128226

Variation tolerance for MEPCE Gene

Residual Variation Intolerance Score: 9.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.94; 35.97% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MEPCE Gene

Disorders for MEPCE Gene

Relevant External Links for MEPCE

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MEPCE Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEPCE Gene

Publications for MEPCE Gene

  1. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PMID: 17643375) Jeronimo C. … Coulombe B. (Mol. Cell 2007) 2 3 4 67
  2. Identification and characterization of a novel gene encoding a SEREX antigen in chronic myeloid leukaemia. (PMID: 12358911) Rogers S.A. … Lim S.H. (Br. J. Haematol. 2002) 2 3
  3. Targeting HIV transcription: the quest for a functional cure. (PMID: 25731772) Mousseau G. … Valente S.T. (Curr. Top. Microbiol. Immunol. 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for MEPCE Gene

Sources for MEPCE Gene