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Aliases for MEPCE Gene

Aliases for MEPCE Gene

  • Methylphosphate Capping Enzyme 2 3 5
  • Bicoid-Interacting Protein 3 Homolog 3 4
  • Bin3 Homolog 3 4
  • BCDIN3 3 4
  • Bin3, Bicoid-Interacting 3, Homolog (Drosophila) 2
  • 7SK SnRNA Methylphosphate Capping Enzyme 3
  • Bin3, Bicoid-Interacting 3, Homolog 3
  • EC 2.1.1.- 4
  • MePCE 4

External Ids for MEPCE Gene

Previous HGNC Symbols for MEPCE Gene

  • BCDIN3

Previous GeneCards Identifiers for MEPCE Gene

  • GC07P099866
  • GC07P100026
  • GC07P094659

Summaries for MEPCE Gene

GeneCards Summary for MEPCE Gene

MEPCE (Methylphosphate Capping Enzyme) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and S-adenosylmethionine-dependent methyltransferase activity.

UniProtKB/Swiss-Prot for MEPCE Gene

  • S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5-end of 7SK snRNA, leading to stabilize it.

Additional gene information for MEPCE Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEPCE Gene

Genomics for MEPCE Gene

Regulatory Elements for MEPCE Gene

Enhancers for MEPCE Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H100538 2 FANTOM5 Ensembl ENCODE dbSUPER 39.9 +115.9 115916 12.6 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 GLIS1 RCOR2 SAP25 SRRT MEPCE PPP1R35 ZSCAN25 GIGYF1 AP4M1 PCOLCE-AS1 FBXO24 LRCH4
GH07H099471 1.1 ENCODE 48.1 -956.1 -956095 3 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZSCAN25 PTCD1 PPP1R35 TRRAP TRIM4 MEPCE STAG3L5P LOC100419643 AP4M1 LOC101927550
GH07H100427 1.5 ENCODE dbSUPER 34.3 +4.5 4502 10.8 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC ZC3H11A ZSCAN25 SRRT GIGYF1 TRIM4 AP4M1 PILRA LOC100131859 ZNF3 PPP1R35 ZSCAN21
GH07H099616 1.4 ENCODE dbSUPER 36.5 -810.4 -810430 4.5 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 ZSCAN25 TRRAP ZNF3 AP4M1 TRIM4 ENSG00000242798 LOC100131859 LOC100419643 PPP1R35 PTCD1
GH07H100475 1.4 ENCODE dbSUPER 35.3 +49.1 49057 4.4 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B ZSCAN25 TRIM4 GIGYF1 ZNF3 ZNF655 SRRT AP4M1 ENSG00000242798 STAG3L5P PILRA
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MEPCE on UCSC Golden Path with GeneCards custom track

Promoters for MEPCE Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000215790 802 2601 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF548 SP3 NFYC ZC3H11A ZFP41

Genomic Locations for MEPCE Gene

Genomic Locations for MEPCE Gene
chr7:100,428,698-100,434,126
(GRCh38/hg38)
Size:
5,429 bases
Orientation:
Plus strand
chr7:100,026,413-100,031,749
(GRCh37/hg19)

Genomic View for MEPCE Gene

Genes around MEPCE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEPCE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEPCE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEPCE Gene

Proteins for MEPCE Gene

  • Protein details for MEPCE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L2J0-MEPCE_HUMAN
    Recommended name:
    7SK snRNA methylphosphate capping enzyme
    Protein Accession:
    Q7L2J0
    Secondary Accessions:
    • B3KP86
    • D6W5V7
    • Q9NPD4

    Protein attributes for MEPCE Gene

    Size:
    689 amino acids
    Molecular mass:
    74355 Da
    Quaternary structure:
    • Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, MEPCE/BCDIN3, SART3 proteins and 7SK and U6 snRNAs.
    SequenceCaution:
    • Sequence=AAF74767.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH16396.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91040.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MEPCE Gene

    Alternative splice isoforms for MEPCE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEPCE Gene

Post-translational modifications for MEPCE Gene

  • Ubiquitination at Lys635
  • Modification sites at PhosphoSitePlus

Other Protein References for MEPCE Gene

No data available for DME Specific Peptides for MEPCE Gene

Domains & Families for MEPCE Gene

Gene Families for MEPCE Gene

Protein Domains for MEPCE Gene

Suggested Antigen Peptide Sequences for MEPCE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L2J0

UniProtKB/Swiss-Prot:

MEPCE_HUMAN :
  • Belongs to the methyltransferase superfamily.
Family:
  • Belongs to the methyltransferase superfamily.
genes like me logo Genes that share domains with MEPCE: view

Function for MEPCE Gene

Molecular function for MEPCE Gene

UniProtKB/Swiss-Prot Function:
S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5-end of 7SK snRNA, leading to stabilize it.

Enzyme Numbers (IUBMB) for MEPCE Gene

Phenotypes From GWAS Catalog for MEPCE Gene

Gene Ontology (GO) - Molecular Function for MEPCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0008168 methyltransferase activity IEA --
GO:0008173 RNA methyltransferase activity IDA 17643375
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity IDA 17643375
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with MEPCE: view
genes like me logo Genes that share phenotypes with MEPCE: view

Animal Models for MEPCE Gene

MGI Knock Outs for MEPCE:

Clone Products

  • Addgene plasmids for MEPCE

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MEPCE Gene

Localization for MEPCE Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEPCE gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MEPCE Gene

Pathways & Interactions for MEPCE Gene

SuperPathways for MEPCE Gene

No Data Available

Gene Ontology (GO) - Biological Process for MEPCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001510 RNA methylation IDA 17643375
GO:0016073 snRNA metabolic process IDA 17643375
GO:0032259 methylation IEA --
GO:0035562 negative regulation of chromatin binding IEA --
genes like me logo Genes that share ontologies with MEPCE: view

No data available for Pathways by source and SIGNOR curated interactions for MEPCE Gene

Drugs & Compounds for MEPCE Gene

(1) Additional Compounds for MEPCE Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
s-adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
  • 2-S-Adenosyl-L-methionine
  • 5'-Deoxyadenosine-5'-L-methionine disulfate ditosylate
  • 5'-Deoxyadenosine-5'-L-methionine disulphate ditosylate
  • Active methionine
29908-03-0
genes like me logo Genes that share compounds with MEPCE: view

Transcripts for MEPCE Gene

Unigene Clusters for MEPCE Gene

Methylphosphate capping enzyme:
Representative Sequences:

Clone Products

  • Addgene plasmids for MEPCE

Alternative Splicing Database (ASD) splice patterns (SP) for MEPCE Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
SP1:
SP2: - - - - -
SP3: - - - -
SP4: - -
SP5: - - -
SP6:
SP7: - -

Relevant External Links for MEPCE Gene

GeneLoc Exon Structure for
MEPCE
ECgene alternative splicing isoforms for
MEPCE

Expression for MEPCE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MEPCE Gene

Protein differential expression in normal tissues from HIPED for MEPCE Gene

This gene is overexpressed in Lung (22.8), Peripheral blood mononuclear cells (14.9), and Heart (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MEPCE Gene



Protein tissue co-expression partners for MEPCE Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MEPCE Gene:

MEPCE

SOURCE GeneReport for Unigene cluster for MEPCE Gene:

Hs.178011

mRNA Expression by UniProt/SwissProt for MEPCE Gene:

Q7L2J0-MEPCE_HUMAN
Tissue specificity: Expressed in chronic myeloid leukemia cells, adrenal gland, brain, cerebellum, kidney, lung, mammary gland and testis. Weakly or not expressed in other tissues.

Evidence on tissue expression from TISSUES for MEPCE Gene

  • Nervous system(4.7)
  • Intestine(4.4)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with MEPCE: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MEPCE Gene

Orthologs for MEPCE Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MEPCE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEPCE 33 34
  • 99.13 (n)
cow
(Bos Taurus)
Mammalia BCDIN3 34
  • 92 (a)
OneToOne
MEPCE 33
  • 89.89 (n)
dog
(Canis familiaris)
Mammalia MEPCE 33 34
  • 91.41 (n)
mouse
(Mus musculus)
Mammalia Mepce 33 16 34
  • 86.99 (n)
oppossum
(Monodelphis domestica)
Mammalia MEPCE 34
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MEPCE 34
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.110 33
zebrafish
(Danio rerio)
Actinopterygii MEPCE (1 of 2) 34
  • 46 (a)
OneToMany
mepce 34
  • 43 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1239 34
  • 39 (a)
OneToMany
bin3 34
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y17G7B.18 34
  • 38 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G51130 33
  • 47.88 (n)
rice
(Oryza sativa)
Liliopsida Os08g0540500 33
  • 46.83 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11343 34
  • 48 (a)
OneToOne
Species where no ortholog for MEPCE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MEPCE Gene

ENSEMBL:
Gene Tree for MEPCE (if available)
TreeFam:
Gene Tree for MEPCE (if available)

Paralogs for MEPCE Gene

No data available for Paralogs for MEPCE Gene

Variants for MEPCE Gene

Sequence variations from dbSNP and Humsavar for MEPCE Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000000630 -- 100,432,796(+) AGTCT(A/G)AGAAG intron-variant
rs1000333534 -- 100,428,392(+) CGTCC(C/T)GGGAA intron-variant, upstream-variant-2KB
rs1000499934 -- 100,432,794(+) TTAGT(C/T)TGAGA intron-variant
rs1000645204 -- 100,427,491(+) GGTCA(C/G)GAGTT intron-variant, upstream-variant-2KB
rs1000676116 -- 100,427,923(+) AATCT(C/G)CCCTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MEPCE Gene

Variant ID Type Subtype PubMed ID
nsv831071 CNV loss 17160897
nsv527107 CNV loss 19592680
esv2734888 CNV deletion 23290073
dgv1226e199 CNV deletion 23128226

Variation tolerance for MEPCE Gene

Residual Variation Intolerance Score: 9.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.94; 35.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MEPCE Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEPCE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEPCE Gene

Disorders for MEPCE Gene

Relevant External Links for MEPCE

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MEPCE

No disorders were found for MEPCE Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEPCE Gene

Publications for MEPCE Gene

  1. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PMID: 17643375) Jeronimo C … Coulombe B (Molecular cell 2007) 2 3 4 60
  2. Identification and characterization of a novel gene encoding a SEREX antigen in chronic myeloid leukaemia. (PMID: 12358911) Rogers SA … Lim SH (British journal of haematology 2002) 2 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for MEPCE Gene

  • Addgene plasmids for MEPCE

Sources for MEPCE Gene

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